CleftGeneDB-Search

Gene: CYP2E1

Basic information

Tag	Content
Uniprot ID	P05181; Q5VZD5; Q6NWT9; Q9UK47;
Entrez ID	1571
Genbank protein ID	AAA52155.1; AAA35743.1; EAW61357.1; ABF47105.1; AAD13753.1; AAH67433.1; BAA08796.1; AAF13601.1;
Genbank nucleotide ID	NM_000773.3
Ensembl protein ID	ENSP00000252945; ENSP00000440689;
Ensembl nucleotide ID	ENSG00000130649
Gene name	Cytochrome P450 2E1
Gene symbol	CYP2E1
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type	CPO,CL/P
Developmental stage
Data sources	Manually collected
Reference	17506098
Functional description	A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable).
Sequence	MSALGVTVAL LVWAAFLLLV SMWRQVHSSW NLPPGPFPLP IIGNLFQLEL KNIPKSFTRL 60 AQRFGPVFTL YVGSQRMVVM HGYKAVKEAL LDYKDEFSGR GDLPAFHAHR DRGIIFNNGP 120 TWKDIRRFSL TTLRNYGMGK QGNESRIQRE AHFLLEALRK TQGQPFDPTF LIGCAPCNVI 180 ADILFRKHFD YNDEKFLRLM YLFNENFHLL STPWLQLYNN FPSFLHYLPG SHRKVIKNVA 240 EVKEYVSERV KEHHQSLDPN CPRDLTDCLL VEMEKEKHSA ERLYTMDGIT VTVADLFFAG 300 TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRIPA IKDRQEMPYM DAVVHEIQRF 360 ITLVPSNLPH EATRDTIFRG YLIPKGTVVV PTLDSVLYDN QEFPDPEKFK PEHFLNENGK 420 FKYSDYFKPF STGKRVCAGE GLARMELFLL LCAILQHFNL KPLVDPKDID LSPIHIGFGC 480 IPPRYKLCVI PRS 493

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
3E4E
3E6I
3GPH
3KOH
3LC4
3T3Z
3E6I
3KOH
3LC4

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	CYP2E1	282213	Q2TBV4		Bos taurus	Prediction	More>>
1:1 ortholog	CYP2E1	415128	Q9MZY0		Canis lupus familiaris	Prediction	More>>
1:1 ortholog	CYP2E1	102182294	A0A452DL40		Capra hircus	Prediction	More>>
1:1 ortholog	CYP2E1	1571	P05181	CPO,CL/P	Homo sapiens	Publication	More>>
1:1 ortholog	Cyp2e1	13106	Q05421		Mus musculus	Prediction	More>>
1:1 ortholog	CYP2E1	450857	A0A2J8J1H0		Pan troglodytes	Prediction	More>>
1:1 ortholog	CYP2E1		F1SCT4		Sus scrofa	Prediction	More>>
1:1 ortholog	Cyp2e1	25086	P05182		Rattus norvegicus	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs753713804	p.Leu4Phe	missense variant	-	NC_000010.11:g.133527405C>T	ExAC,gnomAD
rs1401576094	p.Gly5Arg	missense variant	-	NC_000010.11:g.133527408G>A	TOPMed
rs1338671524	p.Val8Met	missense variant	-	NC_000010.11:g.133527417G>A	gnomAD
rs543066971	p.Leu11Met	missense variant	-	NC_000010.11:g.133527426C>A	1000Genomes,ExAC,gnomAD
rs1457901117	p.Val12Leu	missense variant	-	NC_000010.11:g.133527429G>T	gnomAD
rs1457901117	p.Val12Met	missense variant	-	NC_000010.11:g.133527429G>A	gnomAD
rs757352167	p.Trp13Leu	missense variant	-	NC_000010.11:g.133527433G>T	ExAC,gnomAD
rs563043306	p.Ala14Val	missense variant	-	NC_000010.11:g.133527436C>T	1000Genomes,ExAC,gnomAD
rs1467974326	p.Ala15Val	missense variant	-	NC_000010.11:g.133527439C>T	TOPMed
rs367957731	p.Leu17Phe	missense variant	-	NC_000010.11:g.133527444C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs780358119	p.Leu19Pro	missense variant	-	NC_000010.11:g.133527451T>C	ExAC,gnomAD
rs1402586895	p.Val20Met	missense variant	-	NC_000010.11:g.133527453G>A	gnomAD
rs1336298850	p.Met22Thr	missense variant	-	NC_000010.11:g.133527460T>C	gnomAD
rs772430702	p.Met22Ile	missense variant	-	NC_000010.11:g.133527461G>C	TOPMed
rs900694954	p.Met22Val	missense variant	-	NC_000010.11:g.133527459A>G	TOPMed
rs772430702	p.Met22Ile	missense variant	-	NC_000010.11:g.133527461G>A	TOPMed
rs1377320782	p.Trp23Ter	stop gained	-	NC_000010.11:g.133527463G>A	gnomAD
rs59868347	p.Val26Met	missense variant	-	NC_000010.11:g.133527471G>A	TOPMed
rs769059259	p.Val26Gly	missense variant	-	NC_000010.11:g.133527472T>G	ExAC,gnomAD
NCI-TCGA novel	p.Ser28Ile	missense variant	-	NC_000010.11:g.133527478G>T	NCI-TCGA
rs773963522	p.Ser28Asn	missense variant	-	NC_000010.11:g.133527478G>A	ExAC,gnomAD
rs775675704	p.Ser28Gly	missense variant	-	NC_000010.11:g.133527477A>G	gnomAD
rs1259959217	p.Ser29Arg	missense variant	-	NC_000010.11:g.133527480A>C	gnomAD
rs1317965193	p.Ser29Thr	missense variant	-	NC_000010.11:g.133527481G>C	gnomAD
NCI-TCGA novel	p.Trp30Ter	stop gained	-	NC_000010.11:g.133527485G>A	NCI-TCGA
NCI-TCGA novel	p.Trp30Cys	missense variant	-	NC_000010.11:g.133527485G>T	NCI-TCGA
rs1443704595	p.Asn31Ile	missense variant	-	NC_000010.11:g.133527487A>T	TOPMed
COSM1474507	p.Leu32Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133527489C>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Pro33Arg	missense variant	-	NC_000010.11:g.133527493C>G	NCI-TCGA
rs1260858117	p.Pro33Ser	missense variant	-	NC_000010.11:g.133527492C>T	gnomAD
rs1484033642	p.Pro34Thr	missense variant	-	NC_000010.11:g.133527495C>A	gnomAD
rs747825060	p.Pro36Ala	missense variant	-	NC_000010.11:g.133527501C>G	ExAC,gnomAD
rs1428404245	p.Phe37Leu	missense variant	-	NC_000010.11:g.133527506C>G	gnomAD
rs771599544	p.Phe37Leu	missense variant	-	NC_000010.11:g.133527504T>C	ExAC,gnomAD
rs76271067	p.Pro38Leu	missense variant	-	NC_000010.11:g.133527508C>T	ESP,ExAC,TOPMed,gnomAD
rs76271067	p.Pro38Arg	missense variant	-	NC_000010.11:g.133527508C>G	ESP,ExAC,TOPMed,gnomAD
COSM6129164	p.Ile42Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133527521C>G	NCI-TCGA Cosmic
rs759372423	p.Gly43Arg	missense variant	-	NC_000010.11:g.133527522G>A	ExAC,TOPMed,gnomAD
rs527949682	p.Asn44Lys	missense variant	-	NC_000010.11:g.133527527C>A	1000Genomes,ExAC,gnomAD
rs527949682	p.Asn44Lys	missense variant	-	NC_000010.11:g.133527527C>G	1000Genomes,ExAC,gnomAD
rs1241054527	p.Gln47Glu	missense variant	-	NC_000010.11:g.133527534C>G	TOPMed
NCI-TCGA novel	p.Glu49Ter	missense variant	-	NC_000010.11:g.133527540G>T	NCI-TCGA
rs143746211	p.Asn52Ser	missense variant	-	NC_000010.11:g.133527550A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs143746211	p.Asn52Thr	missense variant	-	NC_000010.11:g.133527550A>C	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ile53Thr	missense variant	-	NC_000010.11:g.133527553T>C	NCI-TCGA
rs750499891	p.Pro54Leu	missense variant	-	NC_000010.11:g.133527556C>T	ExAC,gnomAD
rs1265920662	p.Pro54Ser	missense variant	-	NC_000010.11:g.133527555C>T	TOPMed,gnomAD
rs958141259	p.Ser56Phe	missense variant	-	NC_000010.11:g.133527562C>T	TOPMed
rs756596289	p.Phe57Leu	missense variant	-	NC_000010.11:g.133527564T>C	ExAC,TOPMed,gnomAD
rs780517566	p.Thr58Ser	missense variant	-	NC_000010.11:g.133527567A>T	ExAC,gnomAD
rs1259826192	p.Arg59Trp	missense variant	-	NC_000010.11:g.133527570C>T	TOPMed,gnomAD
rs779311330	p.Arg59Pro	missense variant	-	NC_000010.11:g.133527571G>C	ExAC,TOPMed,gnomAD
rs779311330	p.Arg59Gln	missense variant	-	NC_000010.11:g.133527571G>A	ExAC,TOPMed,gnomAD
rs768536485	p.Gln62Glu	missense variant	-	NC_000010.11:g.133528487C>G	ExAC,gnomAD
rs773302720	p.Gln62Arg	missense variant	-	NC_000010.11:g.133528488A>G	ExAC,gnomAD
rs1354838426	p.Arg63His	missense variant	-	NC_000010.11:g.133528491G>A	TOPMed,gnomAD
rs374426412	p.Arg63Cys	missense variant	-	NC_000010.11:g.133528490C>T	ESP,ExAC,TOPMed,gnomAD
rs374426412	p.Arg63Gly	missense variant	-	NC_000010.11:g.133528490C>G	ESP,ExAC,TOPMed,gnomAD
rs1294436417	p.Phe64Leu	missense variant	-	NC_000010.11:g.133528495C>A	TOPMed,gnomAD
rs80297454	p.Gly65Arg	missense variant	-	NC_000010.11:g.133528496G>A	gnomAD
rs80297454	p.Gly65Arg	missense variant	-	NC_000010.11:g.133528496G>C	gnomAD
COSM116829	p.Thr69Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133528509C>G	NCI-TCGA Cosmic
rs1324031177	p.Thr69Met	missense variant	-	NC_000010.11:g.133528509C>T	TOPMed,gnomAD
rs35844228	p.Val72Leu	missense variant	-	NC_000010.11:g.133528517G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs35844228	p.Val72Met	missense variant	-	NC_000010.11:g.133528517G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs35844228	p.Val72Leu	missense variant	-	NC_000010.11:g.133528517G>C	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gly73Asp	missense variant	-	NC_000010.11:g.133528521G>A	NCI-TCGA
rs764575539	p.Ser74Leu	missense variant	-	NC_000010.11:g.133528524C>T	ExAC,TOPMed,gnomAD
rs72559710	p.Arg76Pro	missense variant	-	NC_000010.11:g.133528530G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs72559710	p.Arg76His	missense variant	-	NC_000010.11:g.133528530G>A	UniProt,dbSNP
VAR_008360	p.Arg76His	missense variant	-	NC_000010.11:g.133528530G>A	UniProt
rs72559710	p.Arg76His	missense variant	-	NC_000010.11:g.133528530G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1329756728	p.Arg76Cys	missense variant	-	NC_000010.11:g.133528529C>T	TOPMed
rs72559710	p.Arg76Leu	missense variant	-	NC_000010.11:g.133528530G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs756973880	p.Val78Met	missense variant	-	NC_000010.11:g.133528535G>A	ExAC,TOPMed,gnomAD
rs1179970516	p.Met80Ile	missense variant	-	NC_000010.11:g.133528543G>T	gnomAD
rs967340990	p.His81Gln	missense variant	-	NC_000010.11:g.133528546C>G	TOPMed,gnomAD
rs1468421016	p.His81Leu	missense variant	-	NC_000010.11:g.133528545A>T	TOPMed,gnomAD
rs745393299	p.His81Asp	missense variant	-	NC_000010.11:g.133528544C>G	ExAC,gnomAD
rs755735655	p.Gly82Ser	missense variant	-	NC_000010.11:g.133528547G>A	ExAC,TOPMed,gnomAD
rs1397166316	p.Gly82Asp	missense variant	-	NC_000010.11:g.133528548G>A	TOPMed
rs779825840	p.Tyr83Ter	stop gained	-	NC_000010.11:g.133528552C>G	ExAC,gnomAD
rs1171967427	p.Tyr83His	missense variant	-	NC_000010.11:g.133528550T>C	TOPMed
rs749315338	p.Lys84Arg	missense variant	-	NC_000010.11:g.133528554A>G	ExAC,gnomAD
rs1381670040	p.Val86Leu	missense variant	-	NC_000010.11:g.133528559G>T	gnomAD
rs747170540	p.Ala89Val	missense variant	-	NC_000010.11:g.133528569C>T	ExAC,TOPMed,gnomAD
rs771177357	p.Glu96Asp	missense variant	-	NC_000010.11:g.133528591G>C	ExAC,TOPMed,gnomAD
rs776646693	p.Ser98Leu	missense variant	-	NC_000010.11:g.133528596C>T	ExAC,TOPMed,gnomAD
rs1185071578	p.Gly99Asp	missense variant	-	NC_000010.11:g.133528599G>A	TOPMed,gnomAD
rs1185071578	p.Gly99Ala	missense variant	-	NC_000010.11:g.133528599G>C	TOPMed,gnomAD
rs1047104054	p.Leu103Phe	missense variant	-	NC_000010.11:g.133528610C>T	TOPMed,gnomAD
rs764296273	p.Pro104Ser	missense variant	-	NC_000010.11:g.133528613C>T	ExAC,TOPMed,gnomAD
rs543855005	p.Pro104Arg	missense variant	-	NC_000010.11:g.133528614C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs543855005	p.Pro104Leu	missense variant	-	NC_000010.11:g.133528614C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1412420588	p.Ala105Thr	missense variant	-	NC_000010.11:g.133528616G>A	gnomAD
rs750140082	p.Ala108Glu	missense variant	-	NC_000010.11:g.133528626C>A	ExAC,TOPMed,gnomAD
rs750140082	p.Ala108Val	missense variant	-	NC_000010.11:g.133528626C>T	ExAC,TOPMed,gnomAD
rs911058446	p.His109Arg	missense variant	-	NC_000010.11:g.133528629A>G	TOPMed
rs911058446	p.His109Leu	missense variant	-	NC_000010.11:g.133528629A>T	TOPMed
rs899693063	p.Arg110Lys	missense variant	-	NC_000010.11:g.133528632G>A	TOPMed,gnomAD
NCI-TCGA novel	p.Asp111Ala	missense variant	-	NC_000010.11:g.133528635A>C	NCI-TCGA
COSM3436048	p.Gly113Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133531585G>A	NCI-TCGA Cosmic
rs1339182501	p.Gly113Arg	missense variant	-	NC_000010.11:g.133528640G>A	gnomAD
rs777555849	p.Phe116Cys	missense variant	-	NC_000010.11:g.133531594T>G	ExAC,TOPMed,gnomAD
rs770084630	p.Pro120Ser	missense variant	-	NC_000010.11:g.133531605C>T	ExAC,gnomAD
rs1345641544	p.Pro120Leu	missense variant	-	NC_000010.11:g.133531606C>T	gnomAD
rs779948307	p.Thr121Ile	missense variant	-	NC_000010.11:g.133531609C>T	ExAC,gnomAD
rs1371933261	p.Trp122Ter	stop gained	-	NC_000010.11:g.133531613G>A	gnomAD
rs377658981	p.Lys123Glu	missense variant	-	NC_000010.11:g.133531614A>G	ESP,ExAC,TOPMed,gnomAD
COSM3436049	p.Asp124Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133531617G>A	NCI-TCGA Cosmic
rs60719153	p.Arg126Trp	missense variant	-	NC_000010.11:g.133531623C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs56864127	p.Arg126Leu	missense variant	-	NC_000010.11:g.133531624G>T	ExAC,TOPMed,gnomAD
rs56864127	p.Arg126Gln	missense variant	-	NC_000010.11:g.133531624G>A	ExAC,TOPMed,gnomAD
rs773718909	p.Arg127Gln	missense variant	-	NC_000010.11:g.133531627G>A	ExAC,TOPMed,gnomAD
rs772509721	p.Arg127Trp	missense variant	-	NC_000010.11:g.133531626C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe128Leu	missense variant	-	NC_000010.11:g.133531631T>A	NCI-TCGA
COSM3866892	p.Ser129Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133531633C>T	NCI-TCGA Cosmic
rs905415600	p.Leu130Val	missense variant	-	NC_000010.11:g.133531635C>G	gnomAD
rs1290001392	p.Thr132Ile	missense variant	-	NC_000010.11:g.133531642C>T	gnomAD
rs148644999	p.Leu133Phe	missense variant	-	NC_000010.11:g.133531644C>T	ESP,ExAC,TOPMed,gnomAD
rs765056111	p.Arg134Gln	missense variant	-	NC_000010.11:g.133531648G>A	ExAC,TOPMed,gnomAD
rs1239678934	p.Arg134Trp	missense variant	-	NC_000010.11:g.133531647C>T	gnomAD
rs759059865	p.Tyr136Cys	missense variant	-	NC_000010.11:g.133531654A>G	ExAC,TOPMed,gnomAD
rs1456859372	p.Met138Leu	missense variant	-	NC_000010.11:g.133531659A>T	gnomAD
rs764780713	p.Gly139Arg	missense variant	-	NC_000010.11:g.133531662G>A	ExAC,gnomAD
rs752570058	p.Gly139Glu	missense variant	-	NC_000010.11:g.133531663G>A	ExAC,gnomAD
rs1323264151	p.Lys140Arg	missense variant	-	NC_000010.11:g.133531666A>G	TOPMed
rs758334170	p.Gln141Pro	missense variant	-	NC_000010.11:g.133531669A>C	ExAC,TOPMed,gnomAD
rs777502721	p.Gln141His	missense variant	-	NC_000010.11:g.133531670G>C	ExAC,TOPMed,gnomAD
rs1465213740	p.Gln141Ter	stop gained	-	NC_000010.11:g.133531668C>T	gnomAD
rs1311765376	p.Gly142Ala	missense variant	-	NC_000010.11:g.133531672G>C	gnomAD
rs751390447	p.Gly142Ser	missense variant	-	NC_000010.11:g.133531671G>A	ExAC,gnomAD
rs757050207	p.Glu144Asp	missense variant	-	NC_000010.11:g.133531679G>C	ExAC
rs749539588	p.Arg146Gln	missense variant	-	NC_000010.11:g.133531684G>A	ExAC,TOPMed,gnomAD
rs370419762	p.Arg146Trp	missense variant	-	NC_000010.11:g.133531683C>T	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg149Ser	missense variant	-	NC_000010.11:g.133531694G>C	NCI-TCGA
rs200955165	p.Glu150Ala	missense variant	-	NC_000010.11:g.133531696A>C	1000Genomes,ExAC,gnomAD
rs779148806	p.His152Gln	missense variant	-	NC_000010.11:g.133531703C>A	ExAC,gnomAD
rs1033628393	p.His152Arg	missense variant	-	NC_000010.11:g.133531702A>G	TOPMed
rs1208223809	p.Phe153Val	missense variant	-	NC_000010.11:g.133531704T>G	gnomAD
rs373427672	p.Leu154Arg	missense variant	-	NC_000010.11:g.133531708T>G	ESP,ExAC,TOPMed,gnomAD
rs142907528	p.Glu156Val	missense variant	-	NC_000010.11:g.133531714A>T	ESP,ExAC,TOPMed,gnomAD
COSM1346958	p.Ala157Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133531716G>A	NCI-TCGA Cosmic
rs776328834	p.Leu158Ile	missense variant	-	NC_000010.11:g.133531719C>A	ExAC,TOPMed,gnomAD
rs991726526	p.Arg159Ser	missense variant	-	NC_000010.11:g.133531724G>T	TOPMed
rs958935789	p.Arg159Gly	missense variant	-	NC_000010.11:g.133531722A>G	TOPMed
NCI-TCGA novel	p.Thr161Ser	missense variant	-	NC_000010.11:g.133531729C>G	NCI-TCGA
rs759119506	p.Gln162Arg	missense variant	-	NC_000010.11:g.133531732A>G	ExAC,TOPMed,gnomAD
rs1353571191	p.Gln164Ter	stop gained	-	NC_000010.11:g.133532126C>T	gnomAD
COSM3436051	p.Pro165Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133532130C>T	NCI-TCGA Cosmic
rs201167793	p.Pro165Ser	missense variant	-	NC_000010.11:g.133532129C>T	ESP,ExAC,TOPMed,gnomAD
rs201167793	p.Pro165Ala	missense variant	-	NC_000010.11:g.133532129C>G	ESP,ExAC,TOPMed,gnomAD
rs1314163001	p.Pro165Arg	missense variant	-	NC_000010.11:g.133532130C>G	gnomAD
rs1244383308	p.Phe166Ile	missense variant	-	NC_000010.11:g.133532132T>A	gnomAD
rs1320694495	p.Asp167Glu	missense variant	-	NC_000010.11:g.133532137C>A	TOPMed
rs1190685941	p.Asp167Asn	missense variant	-	NC_000010.11:g.133532135G>A	TOPMed,gnomAD
rs755208649	p.Thr169Ser	missense variant	-	NC_000010.11:g.133532142C>G	ExAC,TOPMed,gnomAD
rs755208649	p.Thr169Asn	missense variant	-	NC_000010.11:g.133532142C>A	ExAC,TOPMed,gnomAD
rs750206115	p.Thr169Ser	missense variant	-	NC_000010.11:g.133532141A>T	ExAC,TOPMed,gnomAD
rs758535504	p.Leu171Phe	missense variant	-	NC_000010.11:g.133532147C>T	ExAC,TOPMed,gnomAD
rs139133362	p.Ile172Met	missense variant	-	NC_000010.11:g.133532152C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs566294180	p.Ile172Val	missense variant	-	NC_000010.11:g.133532150A>G	ExAC,TOPMed,gnomAD
rs60452492	p.Gly173Cys	missense variant	-	NC_000010.11:g.133532153G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs60452492	p.Gly173Ser	missense variant	-	NC_000010.11:g.133532153G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs923179921	p.Cys174Ser	missense variant	-	NC_000010.11:g.133532157G>C	TOPMed
rs548262477	p.Ala175Val	missense variant	-	NC_000010.11:g.133532160C>T	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala175Pro	missense variant	-	NC_000010.11:g.133532159G>C	NCI-TCGA
rs56040284	p.Ala175Thr	missense variant	-	NC_000010.11:g.133532159G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs557994567	p.Pro176Ser	missense variant	-	NC_000010.11:g.133532162C>T	TOPMed,gnomAD
rs1272538462	p.Asn178Ser	missense variant	-	NC_000010.11:g.133532169A>G	gnomAD
rs6413419	p.Val179Ile	missense variant	-	NC_000010.11:g.133532171G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs6413419	p.Val179Phe	missense variant	-	NC_000010.11:g.133532171G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs201427783	p.Ile180Met	missense variant	-	NC_000010.11:g.133532176A>G	ExAC,gnomAD
NCI-TCGA novel	p.Ala181Val	missense variant	-	NC_000010.11:g.133532178C>T	NCI-TCGA
rs76138620	p.Asp182Asn	missense variant	-	NC_000010.11:g.133532180G>A	ExAC,TOPMed,gnomAD
COSM3367971	p.Ile183Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133532185C>G	NCI-TCGA Cosmic
rs1318060013	p.Ile183Thr	missense variant	-	NC_000010.11:g.133532184T>C	gnomAD
COSM3436053	p.Leu184Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133532186C>T	NCI-TCGA Cosmic
rs1220862293	p.Phe185Leu	missense variant	-	NC_000010.11:g.133532189T>C	gnomAD
rs1263786649	p.Phe185Leu	missense variant	-	NC_000010.11:g.133532191C>A	gnomAD
COSM6065717	p.Arg186Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133532193G>T	NCI-TCGA Cosmic
rs200871390	p.Arg186His	missense variant	-	NC_000010.11:g.133532193G>A	ExAC,TOPMed,gnomAD
rs140500826	p.Arg186Cys	missense variant	-	NC_000010.11:g.133532192C>T	ESP,ExAC,TOPMed,gnomAD
rs752959099	p.Asp190Asn	missense variant	-	NC_000010.11:g.133532204G>A	ExAC
rs763286285	p.Asn192Ser	missense variant	-	NC_000010.11:g.133532211A>G	ExAC,gnomAD
rs764189163	p.Glu194Asp	missense variant	-	NC_000010.11:g.133532218G>T	ExAC,TOPMed,gnomAD
COSM280263	p.Lys195Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133532220A>C	NCI-TCGA Cosmic
rs1296224047	p.Lys195Met	missense variant	-	NC_000010.11:g.133532220A>T	TOPMed
rs1365307411	p.Arg198Lys	missense variant	-	NC_000010.11:g.133532229G>A	TOPMed
NCI-TCGA novel	p.Met200Ile	missense variant	-	NC_000010.11:g.133532236G>T	NCI-TCGA
rs757401077	p.Met200Leu	missense variant	-	NC_000010.11:g.133532234A>T	ExAC,gnomAD
rs1351088713	p.His208Arg	missense variant	-	NC_000010.11:g.133532259A>G	gnomAD
rs772559232	p.His208Gln	missense variant	-	NC_000010.11:g.133532260C>G	ExAC,gnomAD
rs750987941	p.His208Tyr	missense variant	-	NC_000010.11:g.133532258C>T	ExAC,gnomAD
rs1397676621	p.Leu209Gln	missense variant	-	NC_000010.11:g.133532262T>A	TOPMed,gnomAD
rs1281657912	p.Ser211Gly	missense variant	-	NC_000010.11:g.133532267A>G	gnomAD
rs778445040	p.Thr212Ala	missense variant	-	NC_000010.11:g.133532270A>G	ExAC,TOPMed,gnomAD
rs907445349	p.Pro213Arg	missense variant	-	NC_000010.11:g.133532274C>G	TOPMed
rs577159401	p.Pro213Ser	missense variant	-	NC_000010.11:g.133532273C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1194608147	p.Gln216Lys	missense variant	-	NC_000010.11:g.133532282C>A	TOPMed
rs41299426	p.Asn219Asp	missense variant	-	NC_000010.11:g.133532698A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs41299426	p.Asn219Asp	missense variant	-	NC_000010.11:g.133532698A>G	UniProt,dbSNP
VAR_055382	p.Asn219Asp	missense variant	-	NC_000010.11:g.133532698A>G	UniProt
rs769691101	p.Asn220Thr	missense variant	-	NC_000010.11:g.133532702A>C	ExAC,TOPMed,gnomAD
COSM5580762	p.Pro222Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133532707C>T	NCI-TCGA Cosmic
rs767527110	p.Phe224Ser	missense variant	-	NC_000010.11:g.133532714T>C	ExAC,TOPMed,gnomAD
rs773301045	p.His226Tyr	missense variant	-	NC_000010.11:g.133532719C>T	ExAC,gnomAD
rs1433319688	p.Tyr227Ter	stop gained	-	NC_000010.11:g.133532724C>A	TOPMed
rs761129818	p.Leu228Ser	missense variant	-	NC_000010.11:g.133532726T>C	ExAC,gnomAD
rs761129818	p.Leu228Trp	missense variant	-	NC_000010.11:g.133532726T>G	ExAC,gnomAD
rs766838345	p.Gly230Arg	missense variant	-	NC_000010.11:g.133532731G>A	ExAC,gnomAD
rs1193278838	p.Gly230Glu	missense variant	-	NC_000010.11:g.133532732G>A	gnomAD
rs1327451829	p.Ser231Asn	missense variant	-	NC_000010.11:g.133532735G>A	TOPMed
NCI-TCGA novel	p.Arg233Ter	stop gained	-	NC_000010.11:g.133532740A>T	NCI-TCGA
rs1245708136	p.Arg233Thr	missense variant	-	NC_000010.11:g.133532741G>C	gnomAD
rs1476850745	p.Arg233Ser	missense variant	-	NC_000010.11:g.133532742A>C	gnomAD
rs1172122956	p.Lys234Arg	missense variant	-	NC_000010.11:g.133532744A>G	gnomAD
rs754388548	p.Val235Ile	missense variant	-	NC_000010.11:g.133532746G>A	ExAC,gnomAD
rs375484572	p.Ile236Leu	missense variant	-	NC_000010.11:g.133532749A>T	ESP,ExAC,gnomAD
rs569948279	p.Ile236Thr	missense variant	-	NC_000010.11:g.133532750T>C	1000Genomes
NCI-TCGA novel	p.Asn238MetPheSerTerUnk	frameshift	-	NC_000010.11:g.133532751A>-	NCI-TCGA
rs752221593	p.Asn238Tyr	missense variant	-	NC_000010.11:g.133532755A>T	ExAC,gnomAD
rs758094862	p.Val242Ile	missense variant	-	NC_000010.11:g.133532767G>A	ExAC,gnomAD
NCI-TCGA novel	p.Glu244Val	missense variant	-	NC_000010.11:g.133532774A>T	NCI-TCGA
rs369888957	p.Glu244Asp	missense variant	-	NC_000010.11:g.133532775G>C	ESP,ExAC,gnomAD
rs555344732	p.Tyr245Ter	stop gained	-	NC_000010.11:g.133532778T>A	1000Genomes,ExAC,gnomAD
rs756879881	p.Val246Leu	missense variant	-	NC_000010.11:g.133532779G>T	ExAC,TOPMed,gnomAD
rs756879881	p.Val246Met	missense variant	-	NC_000010.11:g.133532779G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Val250Met	missense variant	-	NC_000010.11:g.133532791G>A	NCI-TCGA
rs1352765108	p.Lys251Asn	missense variant	-	NC_000010.11:g.133532796G>C	gnomAD
rs978002991	p.Glu252Asp	missense variant	-	NC_000010.11:g.133532799G>C	TOPMed,gnomAD
rs745886844	p.His254Tyr	missense variant	-	NC_000010.11:g.133532803C>T	ExAC,gnomAD
NCI-TCGA novel	p.Gln255Lys	missense variant	-	NC_000010.11:g.133532806C>A	NCI-TCGA
NCI-TCGA novel	p.Gln255Ter	stop gained	-	NC_000010.11:g.133532806C>T	NCI-TCGA
NCI-TCGA novel	p.Leu257ProPheSerTerUnkUnk	frameshift	-	NC_000010.11:g.133532812_133532813insCAAACCTGAAT	NCI-TCGA
COSM6065716	p.Leu257Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133532812C>G	NCI-TCGA Cosmic
rs769409483	p.Leu257Arg	missense variant	-	NC_000010.11:g.133532813T>G	ExAC,gnomAD
rs769409483	p.Leu257Gln	missense variant	-	NC_000010.11:g.133532813T>A	ExAC,gnomAD
rs748268978	p.Asn260Ser	missense variant	-	NC_000010.11:g.133532822A>G	ExAC,TOPMed,gnomAD
rs772311713	p.Cys261Ter	stop gained	-	NC_000010.11:g.133532826T>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro262His	missense variant	-	NC_000010.11:g.133532828C>A	NCI-TCGA
rs540609626	p.Pro262Leu	missense variant	-	NC_000010.11:g.133532828C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs372834832	p.Arg263Trp	missense variant	-	NC_000010.11:g.133532830C>T	ESP,ExAC,TOPMed,gnomAD
rs766501004	p.Arg263Gln	missense variant	-	NC_000010.11:g.133532831G>A	ExAC,TOPMed,gnomAD
rs1390074994	p.Asp264His	missense variant	-	NC_000010.11:g.133532833G>C	gnomAD
rs776997036	p.Leu265Phe	missense variant	-	NC_000010.11:g.133532836C>T	ExAC,gnomAD
NCI-TCGA novel	p.Thr266Ser	missense variant	-	NC_000010.11:g.133532840C>G	NCI-TCGA
rs201869253	p.Asp267Asn	missense variant	-	NC_000010.11:g.133532842G>A	ESP,ExAC,gnomAD
rs201869253	p.Asp267Tyr	missense variant	-	NC_000010.11:g.133532842G>T	ESP,ExAC,gnomAD
rs1271339688	p.Cys268Ser	missense variant	-	NC_000010.11:g.133532845T>A	TOPMed
rs1445693067	p.Cys268Trp	missense variant	-	NC_000010.11:g.133532847C>G	gnomAD
rs912558367	p.Val271Met	missense variant	-	NC_000010.11:g.133532854G>A	TOPMed
rs753140012	p.Met273Val	missense variant	-	NC_000010.11:g.133532860A>G	ExAC,gnomAD
rs372404508	p.Glu274Gln	missense variant	-	NC_000010.11:g.133532863G>C	ESP,TOPMed
NCI-TCGA novel	p.Glu276Asp	missense variant	-	NC_000010.11:g.133533758A>C	NCI-TCGA
NCI-TCGA novel	p.Glu276Lys	missense variant	-	NC_000010.11:g.133533756G>A	NCI-TCGA
rs1326260648	p.Lys277Asn	missense variant	-	NC_000010.11:g.133533761G>T	TOPMed
rs1449208969	p.Lys277Arg	missense variant	-	NC_000010.11:g.133533760A>G	TOPMed
rs1316414071	p.His278Arg	missense variant	-	NC_000010.11:g.133533763A>G	gnomAD
rs1190104776	p.His278Gln	missense variant	-	NC_000010.11:g.133533764C>A	TOPMed,gnomAD
rs1383519539	p.Ser279Arg	missense variant	-	NC_000010.11:g.133533767T>G	TOPMed
rs751192911	p.Ala280Val	missense variant	-	NC_000010.11:g.133533769C>T	ExAC,TOPMed,gnomAD
rs749979006	p.Arg282His	missense variant	-	NC_000010.11:g.133533775G>A	ExAC,gnomAD
rs375149895	p.Arg282Cys	missense variant	-	NC_000010.11:g.133533774C>T	ESP,ExAC,TOPMed,gnomAD
rs375149895	p.Arg282Ser	missense variant	-	NC_000010.11:g.133533774C>A	ESP,ExAC,TOPMed,gnomAD
rs138201091	p.Thr285Ala	missense variant	-	NC_000010.11:g.133533783A>G	ESP,ExAC,TOPMed,gnomAD
rs1195094707	p.Thr285Ile	missense variant	-	NC_000010.11:g.133533784C>T	TOPMed
rs1373503578	p.Met286Val	missense variant	-	NC_000010.11:g.133533786A>G	gnomAD
COSM4012941	p.Asp287Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133533789G>A	NCI-TCGA Cosmic
COSM3806821	p.Asp287Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133533791C>A	NCI-TCGA Cosmic
rs61710826	p.Gly288Ser	missense variant	-	NC_000010.11:g.133533792G>A	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ile289Met	missense variant	-	NC_000010.11:g.133533797C>G	NCI-TCGA
rs778681344	p.Thr290Ile	missense variant	-	NC_000010.11:g.133533799C>T	ExAC,gnomAD
rs771160948	p.Val291Met	missense variant	-	NC_000010.11:g.133533801G>A	ExAC,TOPMed,gnomAD
rs745942247	p.Ala294Val	missense variant	-	NC_000010.11:g.133533811C>T	ExAC,gnomAD
rs1007026512	p.Asp295Asn	missense variant	-	NC_000010.11:g.133533813G>A	TOPMed,gnomAD
rs1264055833	p.Ala299Ser	missense variant	-	NC_000010.11:g.133533825G>T	gnomAD
rs533468318	p.Ala299Val	missense variant	-	NC_000010.11:g.133533826C>T	1000Genomes,ExAC,gnomAD
rs761515989	p.Gly300Arg	missense variant	-	NC_000010.11:g.133533828G>A	ExAC,gnomAD
rs750089893	p.Thr301Ser	missense variant	-	NC_000010.11:g.133533831A>T	ExAC,gnomAD
rs201120875	p.Thr303Asn	missense variant	-	NC_000010.11:g.133533838C>A	1000Genomes
rs765869376	p.Thr304Ser	missense variant	-	NC_000010.11:g.133533841C>G	ExAC,gnomAD
rs753706527	p.Ser305Asn	missense variant	-	NC_000010.11:g.133533844G>A	ExAC,gnomAD
rs1385845866	p.Thr307Ile	missense variant	-	NC_000010.11:g.133533850C>T	gnomAD
rs764958966	p.Arg309Ile	missense variant	-	NC_000010.11:g.133533856G>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gly311Glu	missense variant	-	NC_000010.11:g.133533862G>A	NCI-TCGA
rs374740281	p.Leu312Phe	missense variant	-	NC_000010.11:g.133533864C>T	ESP,ExAC,TOPMed,gnomAD
rs973002990	p.Leu313Gln	missense variant	-	NC_000010.11:g.133533868T>A	gnomAD
rs142845267	p.Ile314Ser	missense variant	-	NC_000010.11:g.133533871T>G	ESP
rs746145983	p.Met316Leu	missense variant	-	NC_000010.11:g.133533876A>C	ExAC,gnomAD
rs756153015	p.Tyr318His	missense variant	-	NC_000010.11:g.133533882T>C	ExAC,gnomAD
rs984244601	p.Pro319His	missense variant	-	NC_000010.11:g.133533886C>A	TOPMed,gnomAD
COSM465474	p.Glu320Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133533889A>C	NCI-TCGA Cosmic
rs1251438410	p.Ile321Val	missense variant	-	NC_000010.11:g.133533891A>G	gnomAD
rs915909	p.Ile321Met	missense variant	-	NC_000010.11:g.133533893C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs138223492	p.Glu322Lys	missense variant	-	NC_000010.11:g.133533894G>A	ESP,ExAC,TOPMed,gnomAD
rs773459833	p.Lys324Glu	missense variant	-	NC_000010.11:g.133537065A>G	ExAC,gnomAD
rs746620834	p.Leu325Val	missense variant	-	NC_000010.11:g.133537068C>G	ExAC,gnomAD
rs980349044	p.Glu328Asp	missense variant	-	NC_000010.11:g.133537079A>T	TOPMed
rs980349044	p.Glu328Asp	missense variant	-	NC_000010.11:g.133537079A>C	TOPMed
rs969893824	p.Glu328Ter	stop gained	-	NC_000010.11:g.133537077G>T	TOPMed,gnomAD
rs770517759	p.Ile329Thr	missense variant	-	NC_000010.11:g.133537081T>C	ExAC,TOPMed,gnomAD
rs1337093867	p.Asp330Tyr	missense variant	-	NC_000010.11:g.133537083G>T	gnomAD
rs1212628802	p.Val332Leu	missense variant	-	NC_000010.11:g.133537089G>T	TOPMed
rs764799317	p.Ile333Thr	missense variant	-	NC_000010.11:g.133537093T>C	ExAC,gnomAD
rs775343042	p.Ile333Met	missense variant	-	NC_000010.11:g.133537094T>G	ExAC,gnomAD
rs1466872326	p.Ile333Val	missense variant	-	NC_000010.11:g.133537092A>G	TOPMed
rs1233332302	p.Gly334Arg	missense variant	-	NC_000010.11:g.133537095G>A	gnomAD
rs762813109	p.Pro335Ala	missense variant	-	NC_000010.11:g.133537098C>G	ExAC,TOPMed,gnomAD
rs762813109	p.Pro335Thr	missense variant	-	NC_000010.11:g.133537098C>A	ExAC,TOPMed,gnomAD
rs200228968	p.Arg337Ter	stop gained	-	NC_000010.11:g.133537104C>T	1000Genomes,TOPMed,gnomAD
rs759707874	p.Arg337Leu	missense variant	-	NC_000010.11:g.133537105G>T	ExAC,TOPMed,gnomAD
rs759707874	p.Arg337Gln	missense variant	-	NC_000010.11:g.133537105G>A	ExAC,TOPMed,gnomAD
COSM3414858	p.Pro339Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133537110C>A	NCI-TCGA Cosmic
COSM3436058	p.Pro339Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133537110C>T	NCI-TCGA Cosmic
rs61644766	p.Ile341Met	missense variant	-	NC_000010.11:g.133537118C>G	ESP,ExAC,TOPMed,gnomAD
rs754169072	p.Lys342Glu	missense variant	-	NC_000010.11:g.133537119A>G	ExAC,TOPMed,gnomAD
rs1408513149	p.Asp343Asn	missense variant	-	NC_000010.11:g.133537122G>A	gnomAD
rs1173015245	p.Arg344Lys	missense variant	-	NC_000010.11:g.133537126G>A	gnomAD
rs912887278	p.Gln345Arg	missense variant	-	NC_000010.11:g.133537129A>G	TOPMed
COSM3790634	p.Glu346Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133537131G>C	NCI-TCGA Cosmic
rs1042802318	p.Met347Thr	missense variant	-	NC_000010.11:g.133537135T>C	TOPMed
rs1355581068	p.Met347Leu	missense variant	-	NC_000010.11:g.133537134A>T	gnomAD
rs753186824	p.Tyr349Cys	missense variant	-	NC_000010.11:g.133537141A>G	ExAC,TOPMed,gnomAD
rs1396367463	p.Met350Val	missense variant	-	NC_000010.11:g.133537143A>G	TOPMed
COSM3436060	p.Met350Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133537145G>A	NCI-TCGA Cosmic
rs150514905	p.Met350Arg	missense variant	-	NC_000010.11:g.133537144T>G	ExAC,TOPMed,gnomAD
COSM4012942	p.Asp351Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133537147A>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ala352Ser	missense variant	-	NC_000010.11:g.133537149G>T	NCI-TCGA
COSM3436061	p.Ala352Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133537150C>T	NCI-TCGA Cosmic
rs747302212	p.Val354Leu	missense variant	-	NC_000010.11:g.133537155G>C	ExAC,TOPMed,gnomAD
rs747302212	p.Val354Met	missense variant	-	NC_000010.11:g.133537155G>A	ExAC,TOPMed,gnomAD
rs780820318	p.Arg359Trp	missense variant	-	NC_000010.11:g.133537170C>T	ExAC,TOPMed,gnomAD
rs745528149	p.Arg359Gln	missense variant	-	NC_000010.11:g.133537171G>A	ExAC,TOPMed,gnomAD
rs745528149	p.Arg359Pro	missense variant	-	NC_000010.11:g.133537171G>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe360Leu	missense variant	-	NC_000010.11:g.133537175C>A	NCI-TCGA
rs769239142	p.Ile361Phe	missense variant	-	NC_000010.11:g.133537176A>T	ExAC,gnomAD
rs372279263	p.Thr362Ile	missense variant	-	NC_000010.11:g.133537180C>T	ESP,ExAC,TOPMed,gnomAD
rs762908601	p.Val364Met	missense variant	-	NC_000010.11:g.133537185G>A	ExAC,TOPMed,gnomAD
rs1436679183	p.Val364Ala	missense variant	-	NC_000010.11:g.133537186T>C	TOPMed
NCI-TCGA novel	p.Pro365Ser	missense variant	-	NC_000010.11:g.133537188C>T	NCI-TCGA
rs41299434	p.Ser366Cys	missense variant	-	NC_000010.11:g.133537192C>G	1000Genomes
rs41299434	p.Ser366Cys	missense variant	-	NC_000010.11:g.133537192C>G	UniProt,dbSNP
VAR_055383	p.Ser366Cys	missense variant	-	NC_000010.11:g.133537192C>G	UniProt
rs1239952047	p.Asn367Asp	missense variant	-	NC_000010.11:g.133537194A>G	gnomAD
rs768448978	p.Pro369Leu	missense variant	-	NC_000010.11:g.133537201C>T	ExAC,gnomAD
rs1005539701	p.Glu371Gly	missense variant	-	NC_000010.11:g.133537207A>G	TOPMed,gnomAD
rs59981143	p.Thr373Ala	missense variant	-	NC_000010.11:g.133537212A>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg374Leu	missense variant	-	NC_000010.11:g.133537216G>T	NCI-TCGA
rs370530375	p.Arg374Gly	missense variant	-	NC_000010.11:g.133537215C>G	ESP,ExAC,TOPMed,gnomAD
rs767486762	p.Arg374Gln	missense variant	-	NC_000010.11:g.133537216G>A	ExAC,gnomAD
rs370530375	p.Arg374Ter	stop gained	-	NC_000010.11:g.133537215C>T	ESP,ExAC,TOPMed,gnomAD
rs759847516	p.Asp375Glu	missense variant	-	NC_000010.11:g.133537220C>G	ExAC,TOPMed,gnomAD
rs754046416	p.Asp375Gly	missense variant	-	NC_000010.11:g.133537219A>G	ExAC,gnomAD
rs765355752	p.Phe378Leu	missense variant	-	NC_000010.11:g.133537229C>A	ExAC,gnomAD
rs752748963	p.Gly380Val	missense variant	-	NC_000010.11:g.133537234G>T	ExAC,gnomAD
rs752748963	p.Gly380Glu	missense variant	-	NC_000010.11:g.133537234G>A	ExAC,gnomAD
rs1433121603	p.Tyr381His	missense variant	-	NC_000010.11:g.133537236T>C	gnomAD
COSM916532	p.Leu382Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133537240T>G	NCI-TCGA Cosmic
rs1437497706	p.Leu382Phe	missense variant	-	NC_000010.11:g.133537239C>T	TOPMed
rs752179109	p.Ile383Met	missense variant	-	NC_000010.11:g.133537244C>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro384Thr	missense variant	-	NC_000010.11:g.133537245C>A	NCI-TCGA
rs199856651	p.Lys385Arg	missense variant	-	NC_000010.11:g.133537249A>G	1000Genomes,ExAC,TOPMed,gnomAD
COSM2156359	p.Val388Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133537757G>C	NCI-TCGA Cosmic
rs1327701553	p.Val388Ala	missense variant	-	NC_000010.11:g.133537758T>C	gnomAD
rs1425889399	p.Val388Ile	missense variant	-	NC_000010.11:g.133537757G>A	TOPMed
rs55897648	p.Val389Ile	missense variant	-	NC_000010.11:g.133537760G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs55897648	p.Val389Leu	missense variant	-	NC_000010.11:g.133537760G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs757788272	p.Leu393Val	missense variant	-	NC_000010.11:g.133537772C>G	ExAC,gnomAD
rs60207639	p.Asp394Gly	missense variant	-	NC_000010.11:g.133537776A>G	ESP,ExAC,TOPMed,gnomAD
rs1223857405	p.Asp394Glu	missense variant	-	NC_000010.11:g.133537777C>A	gnomAD
rs59656378	p.Val396Leu	missense variant	-	NC_000010.11:g.133537781G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1027409770	p.Tyr398Phe	missense variant	-	NC_000010.11:g.133537788A>T	TOPMed
rs756521777	p.Asn400Ser	missense variant	-	NC_000010.11:g.133537794A>G	ExAC,gnomAD
rs779561569	p.Gln401Pro	missense variant	-	NC_000010.11:g.133537797A>C	ExAC,gnomAD
NCI-TCGA novel	p.Glu402Asp	missense variant	-	NC_000010.11:g.133537801A>T	NCI-TCGA
rs749034745	p.Asp405Glu	missense variant	-	NC_000010.11:g.133537810T>A	ExAC,gnomAD
rs200177135	p.Pro406Ala	missense variant	-	NC_000010.11:g.133537811C>G	TOPMed,gnomAD
rs1352233539	p.Glu407Gly	missense variant	-	NC_000010.11:g.133537815A>G	TOPMed
rs1304810209	p.Lys408Glu	missense variant	-	NC_000010.11:g.133537817A>G	gnomAD
NCI-TCGA novel	p.Phe409Leu	missense variant	-	NC_000010.11:g.133537822T>A	NCI-TCGA
rs1414127010	p.Phe409Leu	missense variant	-	NC_000010.11:g.133537820T>C	TOPMed
rs1362640892	p.Glu412Ter	stop gained	-	NC_000010.11:g.133537829G>T	gnomAD
rs1304386663	p.Asn416Ser	missense variant	-	NC_000010.11:g.133537842A>G	TOPMed
rs57702102	p.Asn418Ser	missense variant	-	NC_000010.11:g.133537848A>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1328203136	p.Lys420Glu	missense variant	-	NC_000010.11:g.133537853A>G	gnomAD
rs748046628	p.Lys420Met	missense variant	-	NC_000010.11:g.133537854A>T	ExAC,TOPMed,gnomAD
rs2515641	p.Phe421Leu	missense variant	-	NC_000010.11:g.133537858C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs142767992	p.Ser424Gly	missense variant	-	NC_000010.11:g.133537865A>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe427Leu	missense variant	-	NC_000010.11:g.133537876C>G	NCI-TCGA
rs151041343	p.Pro429Ala	missense variant	-	NC_000010.11:g.133537880C>G	ESP,ExAC,TOPMed,gnomAD
rs1182003917	p.Arg435Ter	stop gained	-	NC_000010.11:g.133538785C>T	TOPMed
rs761257042	p.Val436Ala	missense variant	-	NC_000010.11:g.133538789T>C	ExAC,gnomAD
NCI-TCGA novel	p.Cys437Tyr	missense variant	-	NC_000010.11:g.133538792G>A	NCI-TCGA
rs1471904078	p.Cys437Phe	missense variant	-	NC_000010.11:g.133538792G>T	TOPMed
COSM6065715	p.Gly439Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133538798G>T	NCI-TCGA Cosmic
rs1254397224	p.Gly439Arg	missense variant	-	NC_000010.11:g.133538797G>A	TOPMed
rs1196807939	p.Glu440Gly	missense variant	-	NC_000010.11:g.133538801A>G	TOPMed
rs754256199	p.Ala443Asp	missense variant	-	NC_000010.11:g.133538810C>A	ExAC,gnomAD
rs764917641	p.Arg444His	missense variant	-	NC_000010.11:g.133538813G>A	ExAC,gnomAD
rs140969399	p.Arg444Cys	missense variant	-	NC_000010.11:g.133538812C>T	ESP,ExAC,TOPMed,gnomAD
rs764917641	p.Arg444Leu	missense variant	-	NC_000010.11:g.133538813G>T	ExAC,gnomAD
rs764917641	p.Arg444Pro	missense variant	-	NC_000010.11:g.133538813G>C	ExAC,gnomAD
rs199855848	p.Met445Ile	missense variant	-	NC_000010.11:g.133538817G>C	1000Genomes,ExAC,gnomAD
rs1383662089	p.Leu450Ser	missense variant	-	NC_000010.11:g.133538831T>C	gnomAD
NCI-TCGA novel	p.Ala453Asp	missense variant	-	NC_000010.11:g.133538840C>A	NCI-TCGA
rs369066427	p.Ala453Val	missense variant	-	NC_000010.11:g.133538840C>T	ESP,TOPMed
rs1297297780	p.Ala453Thr	missense variant	-	NC_000010.11:g.133538839G>A	TOPMed,gnomAD
rs28969387	p.His457Leu	missense variant	-	NC_000010.11:g.133538852A>T	UniProt,dbSNP
VAR_024727	p.His457Leu	missense variant	-	NC_000010.11:g.133538852A>T	UniProt
rs28969387	p.His457Leu	missense variant	-	NC_000010.11:g.133538852A>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1266958540	p.His457Tyr	missense variant	-	NC_000010.11:g.133538851C>T	TOPMed
COSM4833359	p.Leu463Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133538869C>G	NCI-TCGA Cosmic
rs1395292003	p.Val464Ala	missense variant	-	NC_000010.11:g.133538873T>C	TOPMed
rs187941410	p.Val464Ile	missense variant	-	NC_000010.11:g.133538872G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs769536455	p.Asp465Val	missense variant	-	NC_000010.11:g.133538876A>T	ExAC,TOPMed
rs748372752	p.Pro466Leu	missense variant	-	NC_000010.11:g.133538879C>T	ExAC,gnomAD
rs779104532	p.Pro466Ser	missense variant	-	NC_000010.11:g.133538878C>T	ExAC,gnomAD
rs1256621896	p.Lys467Asn	missense variant	-	NC_000010.11:g.133538883G>T	gnomAD
rs1203554290	p.Asp468Gly	missense variant	-	NC_000010.11:g.133538885A>G	gnomAD
rs1485596221	p.Asp468Asn	missense variant	-	NC_000010.11:g.133538884G>A	gnomAD
rs199954662	p.Asp470Tyr	missense variant	-	NC_000010.11:g.133538890G>T	ESP,ExAC,TOPMed,gnomAD
rs199954662	p.Asp470Asn	missense variant	-	NC_000010.11:g.133538890G>A	ESP,ExAC,TOPMed,gnomAD
rs771433748	p.Leu471Phe	missense variant	-	NC_000010.11:g.133538893C>T	ExAC,TOPMed,gnomAD
rs1393164404	p.Ile474Leu	missense variant	-	NC_000010.11:g.133538902A>C	gnomAD
rs945150523	p.His475Pro	missense variant	-	NC_000010.11:g.133538906A>C	TOPMed,gnomAD
rs1176734765	p.Ile476Val	missense variant	-	NC_000010.11:g.133538908A>G	gnomAD
rs1453966988	p.Gly477Arg	missense variant	-	NC_000010.11:g.133538911G>A	gnomAD
rs1041844199	p.Gly477Val	missense variant	-	NC_000010.11:g.133538912G>T	TOPMed
NCI-TCGA novel	p.Phe478Val	missense variant	-	NC_000010.11:g.133538914T>G	NCI-TCGA
COSM6129162	p.Cys480Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000010.11:g.133538921G>T	NCI-TCGA Cosmic
rs1182952256	p.Pro483Ser	missense variant	-	NC_000010.11:g.133538929C>T	TOPMed
rs55982231	p.Arg484His	missense variant	-	NC_000010.11:g.133538933G>A	ExAC,TOPMed,gnomAD
rs1451003704	p.Arg484Ser	missense variant	-	NC_000010.11:g.133538932C>A	TOPMed,gnomAD
rs1451003704	p.Arg484Cys	missense variant	-	NC_000010.11:g.133538932C>T	TOPMed,gnomAD
rs1184993512	p.Cys488Tyr	missense variant	-	NC_000010.11:g.133538945G>A	TOPMed
rs1436249380	p.Cys488Trp	missense variant	-	NC_000010.11:g.133538946T>G	gnomAD
rs1325698643	p.Pro491Leu	missense variant	-	NC_000010.11:g.133538954C>T	gnomAD
rs147916524	p.Arg492His	missense variant	-	NC_000010.11:g.133538957G>A	ESP,ExAC,TOPMed,gnomAD
rs759928543	p.Arg492Cys	missense variant	-	NC_000010.11:g.133538956C>T	ExAC,TOPMed,gnomAD
rs752341899	p.Ser493Leu	missense variant	-	NC_000010.11:g.133538960C>T	ExAC,TOPMed,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0001418	Adenocarcinoma	group	BEFREE;CTD_human
C0001430	Adenoma	group	BEFREE
C0001956	Alcohol Use Disorder	disease	CTD_human
C0001973	Alcoholic Intoxication, Chronic	disease	BEFREE;CTD_human;LHGDN;PSYGENET
C0002874	Aplastic Anemia	disease	BEFREE
C0002875	Cooley's anemia	disease	BEFREE
C0003431	Antisocial Personality Disorder	disease	BEFREE
C0003467	Anxiety	disease	BEFREE
C0003469	Anxiety Disorders	group	BEFREE
C0003850	Arteriosclerosis	disease	BEFREE
C0004096	Asthma	disease	BEFREE
C0004153	Atherosclerosis	disease	BEFREE
C0005283	beta Thalassemia	disease	LHGDN
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE;LHGDN
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0007102	Malignant tumor of colon	disease	BEFREE
C0007107	Malignant neoplasm of larynx	disease	BEFREE
C0007113	Rectal Carcinoma	disease	BEFREE
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE;CTD_human
C0007137	Squamous cell carcinoma	disease	BEFREE;LHGDN
C0007138	Carcinoma, Transitional Cell	disease	BEFREE
C0007192	Cardiomyopathy, Alcoholic	disease	BEFREE
C0007193	Cardiomyopathy, Dilated	group	BEFREE
C0007847	Malignant tumor of cervix	disease	BEFREE
C0008626	Congenital chromosomal disease	group	BEFREE
C0008677	Bronchitis, Chronic	disease	BEFREE
C0009402	Colorectal Carcinoma	disease	BEFREE
C0009404	Colorectal Neoplasms	group	LHGDN
C0011570	Mental Depression	disease	BEFREE;RGD
C0011581	Depressive disorder	disease	BEFREE
C0011609	Drug Eruptions	group	CTD_human
C0011847	Diabetes	disease	BEFREE
C0011849	Diabetes Mellitus	group	BEFREE
C0011854	Diabetes Mellitus, Insulin-Dependent	disease	BEFREE
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	disease	RGD
C0013221	Drug toxicity	group	CTD_human
C0014599	Epithelial hyperplasia	disease	BEFREE
C0014859	Esophageal Neoplasms	group	BEFREE
C0015230	Exanthema	phenotype	BEFREE
C0015695	Fatty Liver	disease	BEFREE;CTD_human;LHGDN;RGD
C0015696	Fatty Liver, Alcoholic	disease	CTD_human;RGD
C0015923	Fetal Alcohol Syndrome	disease	BEFREE
C0016059	Fibrosis	phenotype	LHGDN
C0017154	Gastritis, Atrophic	disease	BEFREE
C0017636	Glioblastoma	disease	BEFREE
C0017638	Glioma	disease	BEFREE
C0018099	Gout	disease	GWASCAT
C0018799	Heart Diseases	group	BEFREE
C0018800	Cardiomegaly	phenotype	CTD_human
C0018801	Heart failure	disease	BEFREE
C0018802	Congestive heart failure	disease	BEFREE
C0019158	Hepatitis	disease	BEFREE;LHGDN
C0019159	Hepatitis A	disease	BEFREE
C0019163	Hepatitis B	disease	BEFREE
C0019193	Hepatitis, Toxic	disease	CTD_human
C0019196	Hepatitis C	disease	BEFREE;LHGDN
C0019207	Hepatoma, Morris	disease	CTD_human
C0019208	Hepatoma, Novikoff	disease	CTD_human
C0020456	Hyperglycemia	disease	BEFREE
C0022116	Ischemia	phenotype	LHGDN
C0022658	Kidney Diseases	group	BEFREE
C0023343	Leprosy	disease	BEFREE
C0023449	Acute lymphocytic leukemia	disease	BEFREE
C0023452	Childhood Acute Lymphoblastic Leukemia	disease	BEFREE
C0023467	Leukemia, Myelocytic, Acute	disease	BEFREE
C0023531	Leukoplakia	disease	BEFREE
C0023890	Liver Cirrhosis	disease	BEFREE;LHGDN
C0023891	Liver Cirrhosis, Alcoholic	disease	BEFREE;CTD_human;LHGDN
C0023895	Liver diseases	group	BEFREE;RGD
C0023896	Alcoholic Liver Diseases	group	BEFREE;LHGDN
C0023903	Liver neoplasms	group	BEFREE;CTD_human
C0023904	Liver Neoplasms, Experimental	group	CTD_human
C0024117	Chronic Obstructive Airway Disease	disease	BEFREE;LHGDN
C0024121	Lung Neoplasms	group	BEFREE;CTD_human;LHGDN
C0024141	Lupus Erythematosus, Systemic	disease	BEFREE
C0024299	Lymphoma	group	BEFREE
C0024301	Lymphoma, Follicular	disease	BEFREE
C0024302	Reticulosarcoma	disease	CTD_human
C0024304	Lymphoma, Mixed-Cell	disease	CTD_human
C0024305	Lymphoma, Non-Hodgkin	disease	BEFREE;CTD_human
C0024306	Lymphoma, Undifferentiated	disease	CTD_human
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0025568	Metaplasia	phenotype	LHGDN
C0026691	Mucocutaneous Lymph Node Syndrome	disease	BEFREE
C0027439	Nasopharyngeal Neoplasms	group	LHGDN
C0027540	Necrosis	phenotype	CTD_human
C0027626	Neoplasm Invasiveness	phenotype	CTD_human
C0027627	Neoplasm Metastasis	phenotype	BEFREE
C0027809	Neurilemmoma	disease	BEFREE
C0027859	Acoustic Neuroma	disease	BEFREE
C0028043	Nicotine Dependence	disease	BEFREE
C0028754	Obesity	disease	BEFREE;CTD_human;RGD
C0030305	Pancreatitis	disease	BEFREE;LHGDN
C0030567	Parkinson Disease	disease	BEFREE;CTD_human
C0030920	Peptic Ulcer	disease	BEFREE
C0031099	Periodontitis	disease	BEFREE
C0032285	Pneumonia	disease	BEFREE
C0033578	Prostatic Neoplasms	group	CTD_human
C0034885	Rectal Neoplasms	group	LHGDN
C0035369	Retroviridae Infections	group	BEFREE
C0036341	Schizophrenia	disease	BEFREE;PSYGENET
C0038356	Stomach Neoplasms	group	LHGDN
C0039730	Thalassemia	group	LHGDN
C0040332	Tobacco Dependence	disease	BEFREE
C0041296	Tuberculosis	disease	BEFREE
C0041327	Tuberculosis, Pulmonary	disease	BEFREE
C0041755	Adverse reaction to drug	group	CTD_human
C0042963	Vomiting	phenotype	BEFREE
C0079740	High Grade Lymphoma (neoplasm)	disease	CTD_human
C0079741	Lymphoma, Intermediate-Grade	disease	CTD_human
C0079747	Low Grade Lymphoma (neoplasm)	disease	CTD_human
C0079757	Diffuse Mixed-Cell Lymphoma	disease	CTD_human
C0079770	Lymphoma, Small Noncleaved-Cell	disease	CTD_human
C0085695	Chronic gastritis	disease	BEFREE
C0085762	Alcohol abuse	disease	BEFREE;CTD_human;PSYGENET
C0086404	Experimental Hepatoma	disease	CTD_human
C0149521	Pancreatitis, Chronic	disease	BEFREE
C0149782	Squamous cell carcinoma of lung	disease	BEFREE
C0149925	Small cell carcinoma of lung	disease	BEFREE
C0152013	Adenocarcinoma of lung (disorder)	disease	BEFREE
C0152018	Esophageal carcinoma	disease	BEFREE
C0153381	Malignant neoplasm of mouth	disease	BEFREE
C0153405	Malignant neoplasm of pharynx	disease	BEFREE
C0153633	Malignant neoplasm of brain	disease	BEFREE
C0162309	Adrenoleukodystrophy	disease	BEFREE
C0162557	Liver Failure, Acute	disease	BEFREE
C0162566	Porphyria Cutanea Tarda	disease	BEFREE
C0205641	Adenocarcinoma, Basal Cell	disease	CTD_human
C0205642	Adenocarcinoma, Oxyphilic	disease	CTD_human
C0205643	Carcinoma, Cribriform	disease	CTD_human
C0205644	Carcinoma, Granular Cell	disease	CTD_human
C0205645	Adenocarcinoma, Tubular	disease	CTD_human
C0206720	Squamous Cell Neoplasms	group	LHGDN
C0220624	Adult Brain Neoplasm	disease	BEFREE
C0220641	Lip and Oral Cavity Carcinoma	disease	BEFREE
C0233697	Obsessions	disease	BEFREE
C0236664	Alcohol-Related Disorders	group	BEFREE;PSYGENET
C0239946	Fibrosis, Liver	disease	BEFREE
C0241910	Hepatitis, Autoimmune	disease	BEFREE
C0241913	Halothane Hepatitis	disease	BEFREE
C0242379	Malignant neoplasm of lung	disease	BEFREE;CTD_human
C0262584	Carcinoma, Small Cell	disease	BEFREE
C0267952	Fibrosis of pancreas	disease	BEFREE
C0271907	Acquired aplastic anemia	disease	BEFREE
C0277337	Infection by Polymorphus	disease	BEFREE
C0278701	Gastric Adenocarcinoma	disease	BEFREE
C0278996	Malignant Head and Neck Neoplasm	disease	BEFREE
C0279626	Squamous cell carcinoma of esophagus	disease	BEFREE
C0302592	Cervix carcinoma	disease	BEFREE
C0333873	Squamous intraepithelial lesion	phenotype	BEFREE
C0341439	Chronic liver disease	group	BEFREE
C0345904	Malignant neoplasm of liver	disease	CTD_human
C0376358	Malignant neoplasm of prostate	disease	BEFREE;CTD_human
C0376670	Pancreatitis, Alcoholic	disease	BEFREE
C0400943	Cirrhosis - non-alcoholic	disease	BEFREE
C0400966	Non-alcoholic Fatty Liver Disease	disease	BEFREE;CTD_human
C0406537	Morbilliform Drug Reaction	disease	CTD_human
C0426576	Gastrointestinal symptom	phenotype	BEFREE
C0524910	Hepatitis C, Chronic	disease	BEFREE
C0546837	Malignant neoplasm of esophagus	disease	BEFREE
C0595989	Carcinoma of larynx	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0684249	Carcinoma of lung	disease	BEFREE
C0685938	Malignant neoplasm of gastrointestinal tract	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0747548	Pharyngeal Carcinoma	disease	BEFREE
C0751606	Adult Acute Lymphocytic Leukemia	disease	BEFREE
C0751688	Malignant Squamous Cell Neoplasm	disease	BEFREE
C0850666	Infection caused by Helicobacter pylori	disease	BEFREE
C0851887	Adenoviral infections	group	BEFREE
C0860204	Cholestatic liver disease	disease	BEFREE
C0860207	Drug-Induced Liver Disease	disease	BEFREE;CTD_human
C0878544	Cardiomyopathies	group	BEFREE
C1168401	Squamous cell carcinoma of the head and neck	disease	BEFREE
C1262760	Hepatitis, Drug-Induced	disease	BEFREE;CTD_human
C1298180	Single tumor	phenotype	BEFREE
C1302401	Adenoma of large intestine	disease	BEFREE
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1332977	Childhood Leukemia	disease	BEFREE
C1333763	Gastric Cardia Carcinoma	disease	BEFREE
C1383860	Cardiac Hypertrophy	phenotype	CTD_human
C1402315	Vascular lesions	disease	BEFREE
C1442981	Alcoholic liver damage	disease	BEFREE
C1449563	Cardiomyopathy, Familial Idiopathic	disease	BEFREE
C1458155	Mammary Neoplasms	group	LHGDN
C1512409	Hepatocarcinogenesis	disease	BEFREE
C1527249	Colorectal Cancer	disease	BEFREE
C1609538	Latent Tuberculosis	disease	BEFREE
C1623038	Cirrhosis	disease	BEFREE
C1827377	Slow acetylator due to N-acetyltransferase enzyme variant	disease	BEFREE
C1861453	Pseudohyperkalemia Cardiff	disease	BEFREE
C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	disease	LHGDN
C2145472	Urothelial Carcinoma	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE;CTD_human;LHGDN
C2711227	Steatohepatitis	disease	BEFREE;CTD_human
C2718067	Alcoholic Steatohepatitis	disease	BEFREE;CTD_human
C2931822	Nasopharyngeal carcinoma	disease	BEFREE
C3146244	Alcohol Related Birth Defect	disease	BEFREE
C3241937	Nonalcoholic Steatohepatitis	disease	BEFREE;CTD_human
C3463824	MYELODYSPLASTIC SYNDROME	group	BEFREE
C3658290	Drug-Induced Acute Liver Injury	disease	CTD_human
C3714542	Lymphoma, Diffuse	disease	CTD_human
C3887486	Interstitial lung fibrosis	phenotype	BEFREE
C4048328	cervical cancer	disease	BEFREE
C4076349	Chronic alcoholic liver disease	disease	BEFREE
C4277682	Chemical and Drug Induced Liver Injury	disease	CTD_human
C4279912	Chemically-Induced Liver Toxicity	disease	CTD_human

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0004497	monooxygenase activity	IDA
GO:0004497	monooxygenase activity	TAS
GO:0005506	iron ion binding	IEA
GO:0008392	arachidonic acid epoxygenase activity	IBA
GO:0008395	steroid hydroxylase activity	IBA
GO:0016491	oxidoreductase activity	IDA
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	TAS
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA
GO:0018601	4-nitrophenol 2-monooxygenase activity	IDA
GO:0019825	oxygen binding	TAS
GO:0019899	enzyme binding	IPI
GO:0020037	heme binding	IDA
GO:0020037	heme binding	IBA
GO:0030544	Hsp70 protein binding	ISS
GO:0051879	Hsp90 protein binding	ISS
GO:0070330	aromatase activity	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0002933	lipid hydroxylation	IDA
GO:0006082	organic acid metabolic process	IBA
GO:0006641	triglyceride metabolic process	IEA
GO:0006805	xenobiotic metabolic process	IBA
GO:0006805	xenobiotic metabolic process	TAS
GO:0008202	steroid metabolic process	IMP
GO:0009617	response to bacterium	IEA
GO:0010193	response to ozone	IEA
GO:0010243	response to organonitrogen compound	IEA
GO:0016098	monoterpenoid metabolic process	IDA
GO:0017144	drug metabolic process	IMP
GO:0017144	drug metabolic process	IDA
GO:0017144	drug metabolic process	TAS
GO:0018885	carbon tetrachloride metabolic process	TAS
GO:0018910	benzene metabolic process	TAS
GO:0018960	4-nitrophenol metabolic process	IDA
GO:0019373	epoxygenase P450 pathway	IBA
GO:0042197	halogenated hydrocarbon metabolic process	TAS
GO:0042738	exogenous drug catabolic process	IBA
GO:0042759	long-chain fatty acid biosynthetic process	TAS
GO:0045471	response to ethanol	IEA
GO:0046483	heterocycle metabolic process	IDA
GO:0055114	oxidation-reduction process	IDA
GO:0055114	oxidation-reduction process	IBA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0000139	Golgi membrane	IEA
GO:0005737	cytoplasm	IBA
GO:0005743	mitochondrial inner membrane	ISS
GO:0005789	endoplasmic reticulum membrane	TAS
GO:0031227	intrinsic component of endoplasmic reticulum membrane	IEA
GO:0043231	intracellular membrane-bounded organelle	IBA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211897	Cytochrome P450 - arranged by substrate type	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-211981	Xenobiotics	TAS
R-HSA-211999	CYP2E1 reactions	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-9018677	Biosynthesis of DHA-derived SPMs	TAS
R-HSA-9018678	Biosynthesis of specialized proresolving mediators (SPMs)	TAS
R-HSA-9018682	Biosynthesis of maresins	TAS
R-HSA-9027307	Biosynthesis of maresin-like SPMs	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C072959	1,1,1,2-tetrafluoro-2-chloroethane	CYP2E1 protein results in increased metabolism of 1,1,1,2-tetrafluoro-2-chloroethane	1686224
C495657	1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane	CYP2E1 protein results in increased hydroxylation of 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane	9047321
C024566	1,1,1-trichloroethane	CYP2E1 protein results in increased oxidation of 1,1,1-trichloroethane	1664256
C068320	1,1-dichloro-1-fluoroethane	CYP2E1 protein affects the metabolism of 1,1-dichloro-1-fluoroethane	11684366; 8104122;
C068320	1,1-dichloro-1-fluoroethane	CYP2E1 protein affects the susceptibility to 1,1-dichloro-1-fluoroethane	11407538
C068320	1,1-dichloro-1-fluoroethane	CYP2E1 protein results in increased reduction of 1,1-dichloro-1-fluoroethane	11407538; 9173683;
C501196	1,1-dichloroethane	1,1-dichloroethane results in increased activity of CYP2E1 protein	11606809
C501196	1,1-dichloroethane	1,1-dichloroethane results in increased expression of and results in increased activity of CYP2E1 protein	11606809
C501196	1,1-dichloroethane	1,1-dichloroethane results in increased expression of CYP2E1 protein	11606809
C561619	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea results in increased expression of CYP2E1 mRNA	21383588
C030387	1,2,3,5-tetrachlorobenzene	CYP2E1 protein results in increased metabolism of 1,2,3,5-tetrachlorobenzene	7747284
C030387	1,2,3,5-tetrachlorobenzene	CYP2E1 protein results in increased oxidation of 1,2,3,5-tetrachlorobenzene	7747284
C018673	1,2,4,5-tetrachlorobenzene	1,2,4,5-tetrachlorobenzene results in increased expression of CYP2E1 protein	10696772
C009947	1,2,4-trichlorobenzene	CYP2E1 protein results in increased metabolism of 1,2,4-trichlorobenzene	7747284
C009947	1,2,4-trichlorobenzene	CYP2E1 protein results in increased oxidation of 1,2,4-trichlorobenzene	7747284
C026486	1,2,5,6-dibenzanthracene	1,2,5,6-dibenzanthracene results in increased expression of CYP2E1 mRNA	16269432
C035384	1,2-dichloroethylene	1,2-dichloroethylene inhibits the reaction [CYP2E1 protein results in increased oxidation of 1,3-butadiene]	10828257
C035384	1,2-dichloroethylene	1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]	9851676
C035384	1,2-dichloroethylene	1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Trichloroethylene]	7871537
C035384	1,2-dichloroethylene	1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Vinyl Chloride]	7871537
C035384	1,2-dichloroethylene	1,2-dichloroethylene results in decreased activity of CYP2E1 protein	15205388; 20127315; 9344893; 9671540;
C035384	1,2-dichloroethylene	1,2-dichloroethylene results in decreased expression of CYP2E1 protein	9671540
C035384	1,2-dichloroethylene	1,2-dichloroethylene results in decreased activity of CYP2E1 protein	9458004
D019813	1,2-Dimethylhydrazine	1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein	19497424; 29108773;
D019813	1,2-Dimethylhydrazine	1,2-Dimethylhydrazine results in increased expression of CYP2E1 protein	30720227
D019813	1,2-Dimethylhydrazine	asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein]	29108773
D019813	1,2-Dimethylhydrazine	hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein]	19497424
D019813	1,2-Dimethylhydrazine	zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CYP2E1 protein]	30720227
C118009	1,2-epoxy-4-vinylcyclohexane	[CYP2E1 protein results in increased metabolism of 4-vinylcyclohexene] which results in increased abundance of 1,2-epoxy-4-vinylcyclohexane	11368546
C517214	12-hydroxyellipticine	CYP2E1 protein results in increased chemical synthesis of 12-hydroxyellipticine	22917556
C031763	1,3-butadiene	CYP2E1 protein affects the metabolism of 1,3-butadiene	15470755
C031763	1,3-butadiene	1,2-dichloroethylene inhibits the reaction [CYP2E1 protein results in increased oxidation of 1,3-butadiene]	10828257
C031763	1,3-butadiene	1-aminobenzotriazole inhibits the reaction [CYP2E1 protein results in increased oxidation of 1,3-butadiene]	10828257
C031763	1,3-butadiene	CYP2E1 protein results in increased oxidation of 1,3-butadiene	10828257
C028491	1,3-butylene glycol	1,3-butylene glycol results in increased activity of CYP2E1 protein	2919394
C028491	1,3-butylene glycol	1,3-butylene glycol results in increased expression of CYP2E1 protein	2919394
C038983	1,3-dimethylthiourea	1,3-dimethylthiourea results in increased expression of CYP2E1 protein	10190572
C517215	13-hydroxyellipticine	CYP2E1 protein results in increased chemical synthesis of 13-hydroxyellipticine	22917556
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	CTNNB1 gene mutant form affects the susceptibility to [1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of CYP2E1 protein]	21705713
C025223	1,4-dioxane	1,4-dioxane results in increased activity of CYP2E1 protein	15490126
C025223	1,4-dioxane	1,4-dioxane results in increased expression of and results in increased activity of CYP2E1 protein	15490126
C025223	1,4-dioxane	1,4-dioxane results in increased expression of CYP2E1 mRNA	15490126
C035342	1,4-naphthoquinone	CYP2E1 protein results in increased abundance of 1,4-naphthoquinone	16243959
C055986	19-hydroxy-5,8,11,14-eicosatetraenoic acid	CYP2E1 protein affects the metabolism of 19-hydroxy-5,8,11,14-eicosatetraenoic acid	15205388
C033020	1-aminobenzotriazole	1-aminobenzotriazole inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene]	25243916
C033020	1-aminobenzotriazole	1-aminobenzotriazole results in decreased activity of CYP2E1 protein	15618748
C033020	1-aminobenzotriazole	1-aminobenzotriazole inhibits the reaction [CYP2E1 protein affects the metabolism of Urethane]	12704224
C033020	1-aminobenzotriazole	1-aminobenzotriazole inhibits the reaction [CYP2E1 protein results in increased oxidation of 1,3-butadiene]	10828257
C033020	1-aminobenzotriazole	1-aminobenzotriazole results in decreased activity of CYP2E1 protein	27421776
C118559	1-bromopropane	CYP2E1 protein results in increased susceptibility to 1-bromopropane	19638432
C118559	1-bromopropane	1-bromopropane results in increased expression of CYP2E1	30247689
C118559	1-bromopropane	allyl sulfide inhibits the reaction [1-bromopropane results in increased expression of CYP2E1]	30247689
C065833	1-hydroxymethylpyrene	Pentachlorophenol inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-hydroxymethylpyrene] which results in increased mutagenesis of HPRT1 gene]	25243916
C065833	1-hydroxymethylpyrene	[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-hydroxymethylpyrene	25243916
C065833	1-hydroxymethylpyrene	[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-hydroxymethylpyrene] which results in increased mutagenesis of HPRT1 gene	25243916
D015655	1-Methyl-4-phenylpyridinium	[AQP4 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium] which affects the expression of CYP2E1 mRNA	20615459
C053035	1-methylpyrene	1-aminobenzotriazole inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene]	25243916
C053035	1-methylpyrene	Pentachlorophenol inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene]	25243916
C053035	1-methylpyrene	[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene	25243916; 27913846;
C053035	1-methylpyrene	[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene	25243916
C029350	1-naphthol	CYP2E1 protein results in increased abundance of 1-naphthol	16243959
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of CYP2E1 mRNA	15913567
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of CYP2E1 mRNA	30723492
C024336	1-phenylazo-2-naphthol	CYP2E1 protein results in increased oxidation of 1-phenylazo-2-naphthol	17159775
C037738	1-phenylimidazole	1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]	21842885
C037738	1-phenylimidazole	1-phenylimidazole inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
C037738	1-phenylimidazole	1-phenylimidazole results in decreased activity of CYP2E1 protein	7710944
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CYP2E1 mRNA	26808241
C067411	2,2-dichloro-1,1,1-trifluoroethane	2,2-dichloro-1,1,1-trifluoroethane results in increased activity of CYP2E1 protein	12919722
C067411	2,2-dichloro-1,1,1-trifluoroethane	CYP2E1 protein results in increased susceptibility to 2,2-dichloro-1,1,1-trifluoroethane	12451447
C067411	2,2-dichloro-1,1,1-trifluoroethane	CYP2E1 protein results in increased metabolism of 2,2-dichloro-1,1,1-trifluoroethane	11684365
C067411	2,2-dichloro-1,1,1-trifluoroethane	2,2-dichloro-1,1,1-trifluoroethane results in decreased activity of CYP2E1 protein	12378954
C067411	2,2-dichloro-1,1,1-trifluoroethane	2,2-dichloro-1,1,1-trifluoroethane results in decreased activity of CYP2E1 protein	9144458
C067411	2,2-dichloro-1,1,1-trifluoroethane	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of 2,2-dichloro-1,1,1-trifluoroethane]	7956723
C067411	2,2-dichloro-1,1,1-trifluoroethane	CYP2E1 protein affects the metabolism of 2,2-dichloro-1,1,1-trifluoroethane	11322177; 11684366; 8199305;
C067411	2,2-dichloro-1,1,1-trifluoroethane	CYP2E1 protein results in increased metabolism of 2,2-dichloro-1,1,1-trifluoroethane	7956723
C067411	2,2-dichloro-1,1,1-trifluoroethane	CYP2E1 protein results in increased reduction of 2,2-dichloro-1,1,1-trifluoroethane	9144458
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CYP2E1 mRNA	19114083
C039673	2,3,5,6-tetrachlorophenate	CYP2E1 protein results in increased oxidation of 2,3,5,6-tetrachlorophenate	7747284
C056693	2,3,5-trichlorophenol	CYP2E1 protein results in increased oxidation of 2,3,5-trichlorophenol	7747284
C014211	2,3,7,8-tetrachlorodibenzofuran	2,3,7,8-tetrachlorodibenzofuran results in increased expression of CYP2E1 mRNA	25768209
C076159	2,3-dichloro-1-propanol	CYP2E1 protein affects the susceptibility to 2,3-dichloro-1-propanol	9129171
C541132	2,4,4',5-tetrachlorobiphenyl	[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl	27913846
C541132	2,4,4',5-tetrachlorobiphenyl	[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl] which results in increased mutagenesis of HPRT1 gene	27913846
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CYP2E1 mRNA	11306697
C009407	2,5,2',5'-tetrachlorobiphenyl	[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,5,2',5'-tetrachlorobiphenyl	27913846
C009407	2,5,2',5'-tetrachlorobiphenyl	[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,5,2',5'-tetrachlorobiphenyl] which results in increased mutagenesis of HPRT1 gene	27913846
C028519	2,6-dimethylnaphthalene	CYP2E1 protein results in increased oxidation of 2,6-dimethylnaphthalene	17156750
C007766	2,6-xylidine	CYP2E1 protein affects the metabolism of 2,6-xylidine metabolite	11409937
C007766	2,6-xylidine	Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of 2,6-xylidine metabolite]	11409937
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene analog results in increased expression of CYP2E1 protein	15916741
D015073	2-Acetylaminofluorene	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA	16158176
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of CYP2E1 protein	15916741; 23665045;
D015073	2-Acetylaminofluorene	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP2E1 mRNA	14656948
D015073	2-Acetylaminofluorene	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CYP2E1 protein	17393424
D015073	2-Acetylaminofluorene	Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein]	23665045
C104935	2-(allylthio)pyrazine	2-(allylthio)pyrazine inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	9065729
C104935	2-(allylthio)pyrazine	2-(allylthio)pyrazine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]	9065729
C104935	2-(allylthio)pyrazine	2-(allylthio)pyrazine results in decreased activity of CYP2E1 protein	9065729
C104935	2-(allylthio)pyrazine	2-(allylthio)pyrazine results in decreased expression of CYP2E1 mRNA	9065729
C104935	2-(allylthio)pyrazine	2-(allylthio)pyrazine results in decreased expression of CYP2E1 protein	9065729
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	29362861
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA	29362861
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	5,15-diphenylporphyrin inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]	29362861
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	Ethanol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]	29362861
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]	29362861
C581356	2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine	2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine inhibits the reaction [Dexamethasone results in increased expression of CYP2E1 mRNA]	20501703
C055495	2-aminoacetophenone	2-aminoacetophenone inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	30599194
C055495	2-aminoacetophenone	2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]	30599194
C003898	2-anisidine	CYP2E1 protein results in increased oxidation of 2-anisidine	15828049
C003898	2-anisidine	CYP2E1 protein results in increased oxidation of 2-anisidine	16601807
C034047	2-cresol	CYP2E1 protein affects the metabolism of 2-cresol	8592870
C004726	2-dichlorobenzene	CYP2E1 protein results in increased metabolism of 2-dichlorobenzene	7747284
C004726	2-dichlorobenzene	CYP2E1 protein results in increased oxidation of 2-dichlorobenzene	7747284; 9817075;
C004726	2-dichlorobenzene	[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of 2-dichlorobenzene	9817075
C004726	2-dichlorobenzene	dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of 2-dichlorobenzene]	9817075
C004726	2-dichlorobenzene	[2-dichlorobenzene analog co-treated with NADP] results in decreased activity of CYP2E1 protein	24713513
C004726	2-dichlorobenzene	CYP2E1 protein results in increased oxidation of 2-dichlorobenzene	9817075
C586542	2'-(glutathion-S-yl)-deschlorodiclofenac	[CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac	24246759
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]	28673560
C028405	2-naphthol	CYP2E1 protein results in increased abundance of 2-naphthol	16243959
C005328	2-nitroanisole	CYP2E1 protein results in increased metabolism of 2-nitroanisole	15144223
C005328	2-nitroanisole	CYP2E1 protein results in increased oxidation of 2-nitroanisole	17159769; 21218109;
C005328	2-nitroanisole	CYP2E1 protein results in increased oxidation of 2-nitroanisole	21218109
C045573	2-nitrophenol	CYP2E1 protein affects the chemical synthesis of 2-nitrophenol	11409192
C045573	2-nitrophenol	CYP2E1 protein results in increased oxidation of 2-nitrophenol	17159769
C045573	2-nitrophenol	CYP2E1 protein results in increased oxidation of 2-nitrophenol	20027144
C043384	2-piperidone	CYP2E1 protein results in increased abundance of 2-piperidone	23811823
D019840	2-Propanol	2-Propanol binds to and results in increased expression of CYP2E1 protein	3337723
D019840	2-Propanol	2-Propanol inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D019840	2-Propanol	2-Propanol results in increased expression of CYP2E1 protein	9118891
D019840	2-Propanol	2-Propanol results in decreased activity of CYP2E1 protein	7710944
C026114	2-xylene	CYP2E1 protein results in increased metabolism of 2-xylene	8558417
C026114	2-xylene	CYP2E1 protein results in increased oxidation of 2-xylene	17156750
C026114	2-xylene	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 2-xylene]	8558417
C026114	2-xylene	2-xylene results in increased expression of CYP2E1 protein	8517779; 8996725;
C026114	2-xylene	Acetone promotes the reaction [2-xylene results in increased expression of CYP2E1 protein]	8996725
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP2E1 mRNA	28673560
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP2E1 mRNA	19692669; 23196670;
C024370	3,4-epoxy-1-butene	3,4-epoxy-1-butene results in decreased activity of CYP2E1 protein	24561005
C571631	3-bromomethcathinone	CYP2E1 protein results in increased metabolism of 3-bromomethcathinone	27320963
C482258	3'-hydroxy-genistein	CYP2E1 protein results in increased chemical synthesis of 3'-hydroxy-genistein	12814970
C093383	3-methylbenzaldehyde	3-methylbenzaldehyde results in decreased activity of CYP2E1 protein	12791539
C031285	3-xylene	CYP2E1 protein results in increased hydrolysis of 3-xylene	10353308
C031285	3-xylene	CYP2E1 protein results in increased metabolism of 3-xylene	8558417
C031285	3-xylene	CYP2E1 protein results in increased oxidation of 3-xylene	17156750
C031285	3-xylene	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 3-xylene]	8558417
C031285	3-xylene	3-xylene affects the activity of CYP2E1 protein	15204773; 8598570;
C031285	3-xylene	3-xylene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]	8889796
C031285	3-xylene	3-xylene results in decreased activity of CYP2E1 protein	12791539
C031285	3-xylene	3-xylene results in increased activity of CYP2E1 protein	8889796
C031285	3-xylene	3-xylene results in increased expression of CYP2E1 protein	8517779
C031285	3-xylene	CYP2E1 protein results in increased oxidation of 3-xylene	18247580
C008745	4,4'-bisphenol F	CYP2E1 protein results in increased glutathionylation of 4,4'-bisphenol F metabolite	23470418
C008745	4,4'-bisphenol F	CYP2E1 protein results in increased hydroxylation of 4,4'-bisphenol F	23470418
C570106	4,4'-cyclohexylidenebisphenol	CYP2E1 protein results in increased glutathionylation of 4,4'-cyclohexylidenebisphenol	23470418
C570106	4,4'-cyclohexylidenebisphenol	CYP2E1 protein results in increased hydroxylation of 4,4'-cyclohexylidenebisphenol	23470418
C106616	4,4'-dimethylbiphenyl	CYP2E1 protein results in increased oxidation of 4,4'-dimethylbiphenyl	17156750
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	28385499
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	28385499
C583074	4,4'-hexafluorisopropylidene diphenol	CYP2E1 protein results in increased hydroxylation of 4,4'-hexafluorisopropylidene diphenol	23470418
C545880	4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide	CYP2E1 protein results in increased metabolism of 4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide	19697924
C027226	(4-amidinophenyl)methanesulfonyl fluoride	(4-amidinophenyl)methanesulfonyl fluoride inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
C006757	4-biphenylamine	CYP2E1 gene mutant form results in decreased susceptibility to 4-biphenylamine	25601990
C006757	4-biphenylamine	CYP2E1 protein results in increased hydroxylation of 4-biphenylamine	25601990
C006757	4-biphenylamine	[CYP2E1 protein results in increased hydroxylation of 4-biphenylamine] which results in increased abundance of Reactive Oxygen Species	25601990
C519197	4-bromostyrene	CYP2E1 results in increased metabolism of and results in increased susceptibility to 4-bromostyrene	22366341
C422704	4-chlorostyrene	CYP2E1 results in increased metabolism of and results in increased susceptibility to 4-chlorostyrene	22366341
C032538	4-cresol	CYP2E1 protein affects the metabolism of 4-cresol	8592870
C032538	4-cresol	CYP2E1 protein results in increased metabolism of 4-cresol	16174805
C018511	4-dichlorobenzene	CYP2E1 protein results in increased metabolism of 4-dichlorobenzene	7747284
C018511	4-dichlorobenzene	CYP2E1 protein results in increased oxidation of 4-dichlorobenzene	7747284; 9817075;
C018511	4-dichlorobenzene	4-dichlorobenzene results in increased expression of CYP2E1 protein	10696772
C018511	4-dichlorobenzene	[Isoniazid results in increased activity of CYP2E1 protein] which results in increased metabolism of 4-dichlorobenzene	9051121
C001833	4-nitrocatechol	2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]	30599194
C001833	4-nitrocatechol	[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol	30599194
C001833	4-nitrocatechol	Skatole inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]	30599194
C024836	4-nitrophenol	4-nitrophenol binds to CYP2E1 protein	24924949
C024836	4-nitrophenol	4-nitrophenol inhibits the reaction [CYP2E1 protein results in increased metabolism of Theobromine]	10215755
C024836	4-nitrophenol	4-nitrophenol inhibits the reaction [CYP2E1 protein results in increased oxidation of norflurane]	1356728
C024836	4-nitrophenol	Bucladesine promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136
C024836	4-nitrophenol	Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136; 9143349;
C024836	4-nitrophenol	Cycloheximide inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136; 9143349;
C024836	4-nitrophenol	Cycloheximide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	9143349
C024836	4-nitrophenol	CYP2E1 protein results in increased hydroxylation of 4-nitrophenol	14669323; 15135088; 8558417;
C024836	4-nitrophenol	CYP2E1 protein results in increased metabolism of 4-nitrophenol	12464242; 15576447; 9825833;
C024836	4-nitrophenol	CYP2E1 protein results in increased oxidation of 4-nitrophenol	10207612; 11212141; 8531136; 9143349;
C024836	4-nitrophenol	Dimethylnitrosamine inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
C024836	4-nitrophenol	Ethanol inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
C024836	4-nitrophenol	Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8074729; 8531136;
C024836	4-nitrophenol	ferric-adenosine triphosphate complex inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136
C024836	4-nitrophenol	Fomepizole inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
C024836	4-nitrophenol	IL6 protein promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136
C024836	4-nitrophenol	Tetradecanoylphorbol Acetate inhibits the reaction [Cycloheximide inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
C024836	4-nitrophenol	Tetradecanoylphorbol Acetate promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136; 9143349;
C024836	4-nitrophenol	Tretinoin promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136
C024836	4-nitrophenol	CYP2E1 protein results in increased hydroxylation of 4-nitrophenol	10094576; 15742976;
C024836	4-nitrophenol	2-(allylthio)pyrazine inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	9065729
C024836	4-nitrophenol	4-nitrophenol inhibits the reaction [CYP2E1 protein results in increased metabolism of methylformamide]	1538706
C024836	4-nitrophenol	Acetone promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	8267643
C024836	4-nitrophenol	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]	7601153; 8117321;
C024836	4-nitrophenol	Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]	7601153
C024836	4-nitrophenol	CYP2E1 protein results in increased hydroxylation of 4-nitrophenol	11408273; 11911841; 8267643; 9065729; 9618253;
C024836	4-nitrophenol	CYP2E1 protein results in increased metabolism of 4-nitrophenol	15763544; 26463279; 7601153;
C024836	4-nitrophenol	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	9618253
C024836	4-nitrophenol	Ethanol promotes the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]	7601153
C024836	4-nitrophenol	phenethyl isothiocyanate inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]	7601153
C024836	4-nitrophenol	pyridine promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	9618253
C024836	4-nitrophenol	S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]	15763544
C024836	4-nitrophenol	2-aminoacetophenone inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	30599194
C024836	4-nitrophenol	2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]	30599194
C024836	4-nitrophenol	CYP2E1 protein results in increased hydroxylation of 4-nitrophenol	30599194
C024836	4-nitrophenol	[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol	30599194
C024836	4-nitrophenol	Skatole inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	30599194
C024836	4-nitrophenol	Skatole inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]	30599194
C024836	4-nitrophenol	4-nitrophenol results in decreased activity of CYP2E1 protein	9877205
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	CYP2E1 protein affects the metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	12920169
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	CYP2E1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	12115524
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of CYP2E1 protein	9774145
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	CYP2E1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	25221795
C012606	4-vinyl-1-cyclohexene dioxide	CYP2E1 protein affects the susceptibility to 4-vinyl-1-cyclohexene dioxide	18622027
C012606	4-vinyl-1-cyclohexene dioxide	[CYP2E1 protein results in increased metabolism of 4-vinylcyclohexene] which results in increased chemical synthesis of 4-vinyl-1-cyclohexene dioxide	22061827
C013733	4-vinylcyclohexene	4-vinylcyclohexene results in increased expression of CYP2E1 protein	9929517
C013733	4-vinylcyclohexene	CYP2E1 protein results in increased metabolism of 4-vinylcyclohexene	11368546
C013733	4-vinylcyclohexene	[CYP2E1 protein results in increased metabolism of 4-vinylcyclohexene] which results in increased abundance of 1,2-epoxy-4-vinylcyclohexane	11368546
C013733	4-vinylcyclohexene	CYP2E1 protein results in increased metabolism of 4-vinylcyclohexene	22061827
C013733	4-vinylcyclohexene	[CYP2E1 protein results in increased metabolism of 4-vinylcyclohexene] which results in increased chemical synthesis of 4-vinyl-1-cyclohexene dioxide	22061827
C031286	4-xylene	CYP2E1 protein results in increased metabolism of 4-xylene	8558417
C031286	4-xylene	CYP2E1 protein results in increased oxidation of 4-xylene	17156750
C031286	4-xylene	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-xylene]	8558417
C031286	4-xylene	4-xylene results in increased activity of CYP2E1 protein	12781212
C031286	4-xylene	Disulfiram inhibits the reaction [4-xylene results in increased activity of CYP2E1 protein]	12781212
C031286	4-xylene	CYP2E1 protein results in increased oxidation of 4-xylene	18247580
C540777	5,15-diphenylporphyrin	5,15-diphenylporphyrin inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]	29362861
C040997	5-bromotryptamine	5-bromotryptamine analog results in decreased activity of CYP2E1 protein	26599973
C040997	5-bromotryptamine	[5-bromotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
C529169	5-chlorotryptamine	5-chlorotryptamine analog results in decreased activity of CYP2E1 protein	26599973
C529169	5-chlorotryptamine	[5-chlorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
C051101	5-fluoro-alpha-methyltryptamine	5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2E1 protein	26599973
C051101	5-fluoro-alpha-methyltryptamine	[5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
C034536	5-fluorotryptamine	5-fluorotryptamine analog results in decreased activity of CYP2E1 protein	26599973
C034536	5-fluorotryptamine	[5-fluorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
C033696	5-methoxy-N,N-diisopropyltryptamine	5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein	26599973
C033696	5-methoxy-N,N-diisopropyltryptamine	[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
C027552	5-methyltryptamine	5-methyltryptamine analog results in decreased activity of CYP2E1 protein	26599973
C027552	5-methyltryptamine	[5-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
C475093	6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	[6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Oleic Acid] results in increased expression of CYP2E1 mRNA	30611723
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
C039289	6-hydroxychlorzoxazone	[CYP2E1 mRNA results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone	29555536
C039289	6-hydroxychlorzoxazone	CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone	12401345; 15155557; 21915887; 26739624;
C039289	6-hydroxychlorzoxazone	CYP2E1 protein results in increased hydroxylation of 6-hydroxychlorzoxazone	19900514
C039289	6-hydroxychlorzoxazone	[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone	23669205
C039289	6-hydroxychlorzoxazone	Disulfiram inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]	21915887
C039289	6-hydroxychlorzoxazone	Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]	23669205
C039289	6-hydroxychlorzoxazone	Fomepizole inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]	21915887
C039289	6-hydroxychlorzoxazone	CYP2E1 protein results in increased abundance of 6-hydroxychlorzoxazone	31501917
C039289	6-hydroxychlorzoxazone	[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased abundance of 6-hydroxychlorzoxazone	31501917
C039289	6-hydroxychlorzoxazone	[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone	30503582
C039289	6-hydroxychlorzoxazone	CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone	28438436
C039289	6-hydroxychlorzoxazone	[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone	28438436
C039289	6-hydroxychlorzoxazone	[Dextran Sulfate results in decreased activity of CYP2E1 protein] which results in decreased chemical synthesis of 6-hydroxychlorzoxazone	28438436
C073279	6-phenylhexyl isothiocyanate	6-phenylhexyl isothiocyanate results in decreased activity of CYP2E1 protein	10616189
C056033	7-ethoxy-4-trifluoromethylcoumarin	CYP2E1 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin	9241656
C056033	7-ethoxy-4-trifluoromethylcoumarin	Orphenadrine inhibits the reaction [CYP2E1 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]	9241656
C017299	7-ethoxycoumarin	CYP2E1 protein results in increased metabolism of 7-ethoxycoumarin	18385292
C084236	7-hydroxy-4-trifluoromethylcoumarin	CYP2E1 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin	9241656
C084236	7-hydroxy-4-trifluoromethylcoumarin	Orphenadrine inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]	9241656
C031477	7-hydroxycoumarin	7-hydroxycoumarin inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein]	24661945
C540005	7-methoxy-4-trifluoromethylcoumarin	acetonitrile inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]	19858067
C540005	7-methoxy-4-trifluoromethylcoumarin	CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin	19858067
C540005	7-methoxy-4-trifluoromethylcoumarin	Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]	19858067
C036696	7-methyltryptamine	7-methyltryptamine analog results in decreased activity of CYP2E1 protein	26599973
C036696	7-methyltryptamine	[7-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP2E1 mRNA	22079614
D015127	9,10-Dimethyl-1,2-benzanthracene	CYP2E1 protein affects the susceptibility to 9,10-Dimethyl-1,2-benzanthracene	18622027
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP2E1 mRNA	24576726
C421010	9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole	CYP2E1 protein results in increased chemical synthesis of 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole	15279827
C496492	abrine	abrine results in increased expression of CYP2E1 mRNA	31054353
D020909	Acarbose	Acarbose results in decreased expression of CYP2E1 mRNA	14975757
C001969	acephate	[acephate co-treated with vinclozolin] affects the expression of CYP2E1 protein	17686559
C001969	acephate	[fenarimol co-treated with acephate] affects the expression of CYP2E1 protein	17686559
C001969	acephate	[fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2E1 protein	17686559
D000079	Acetaldehyde	CYP2E1 protein results in increased metabolism of Acetaldehyde	10826103
D000079	Acetaldehyde	[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Acetaldehyde	18845238
D000079	Acetaldehyde	[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde	7562599
D000079	Acetaldehyde	phenethyl isothiocyanate inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde]	7562599
D000082	Acetaminophen	Acetaminophen results in decreased expression of CYP2E1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in decreased expression of CYP2E1 protein	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of CYP2E1 mRNA	26690555; 30567741;
D000082	Acetaminophen	Acetaminophen results in increased expression of CYP2E1 protein	23728527; 30567741;
D000082	Acetaminophen	[CYP2E1 protein co-treated with CYP1A2 protein] results in increased susceptibility to Acetaminophen	28762043
D000082	Acetaminophen	CYP2E1 protein results in increased metabolism of Acetaminophen	12464242; 15576447;
D000082	Acetaminophen	CYP2E1 protein results in increased susceptibility to Acetaminophen	11212141; 28762043;
D000082	Acetaminophen	Ethanol affects the reaction [CYP2E1 protein results in increased susceptibility to Acetaminophen]	11212141
D000082	Acetaminophen	GSTM1 protein inhibits the reaction [[CYP2E1 protein co-treated with CYP1A2 protein] results in increased susceptibility to Acetaminophen]	28762043
D000082	Acetaminophen	PPP2CA protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	30567741
D000082	Acetaminophen	PPP2R5A protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	30567741
D000082	Acetaminophen	PPP2R5A protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	30567741
D000082	Acetaminophen	Acetaminophen affects the expression of CYP2E1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased activity of CYP2E1 protein	26772156
D000082	Acetaminophen	Acetaminophen results in decreased expression of CYP2E1 mRNA	15576447
D000082	Acetaminophen	Acetaminophen results in decreased expression of CYP2E1 protein	15576447; 21329376; 22683606; 29689376;
D000082	Acetaminophen	Acetaminophen results in increased activity of CYP2E1 protein	19256530; 19799668; 20166895; 23333575; 29325178;
D000082	Acetaminophen	[Acetaminophen results in increased activity of CYP2E1 protein] inhibits the reaction [PPARA protein results in increased oxidation of Fatty Acids]	19256530
D000082	Acetaminophen	Acetaminophen results in increased expression of and results in decreased activity of CYP2E1 protein	30423402
D000082	Acetaminophen	Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein	22939915
D000082	Acetaminophen	Acetaminophen results in increased expression of CYP2E1 mRNA	12958197; 16393943; 30423402;
D000082	Acetaminophen	Acetaminophen results in increased expression of CYP2E1 protein	19002106; 20067817;
D000082	Acetaminophen	Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	30423402
D000082	Acetaminophen	Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	30423402
D000082	Acetaminophen	Carnosine inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]	19799668
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of CYP2E1 mRNA	17585979
D000082	Acetaminophen	Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	30423402
D000082	Acetaminophen	Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	30423402
D000082	Acetaminophen	Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	30423402
D000082	Acetaminophen	Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	30423402
D000082	Acetaminophen	Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]	30423402
D000082	Acetaminophen	CYP2E1 protein affects the metabolism of and results in decreased abundance of Acetaminophen	19679878
D000082	Acetaminophen	CYP2E1 protein affects the reaction [Acetaminophen results in increased abundance of acylcarnitine]	19256530
D000082	Acetaminophen	CYP2E1 protein affects the reaction [Acetaminophen results in increased activity of PPARA protein]	19256530
D000082	Acetaminophen	CYP2E1 protein affects the susceptibility to Acetaminophen	19256530
D000082	Acetaminophen	CYP2E1 protein results in increased metabolism of Acetaminophen	19002106
D000082	Acetaminophen	CYP2E1 protein results in increased metabolism of and affects the susceptibility to Acetaminophen	11376689
D000082	Acetaminophen	CYP2E1 protein results in increased metabolism of and results in increased activity of Acetaminophen	25319358
D000082	Acetaminophen	CYP2E1 protein results in increased susceptibility to Acetaminophen	11323178; 16557553; 19679878;
D000082	Acetaminophen	dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]	22939915
D000082	Acetaminophen	Genistein inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]	23333575
D000082	Acetaminophen	hyperoside inhibits the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]	26772156
D000082	Acetaminophen	IL1A protein inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	19002106
D000082	Acetaminophen	KITL protein inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	12594235
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP2E1 mRNA]	17585979
D000082	Acetaminophen	PPARA protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	12958197
D000082	Acetaminophen	S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]	22683606
D000082	Acetaminophen	schizandrol B inhibits the reaction [CYP2E1 protein results in increased metabolism of and results in increased activity of Acetaminophen]	25319358
D000082	Acetaminophen	SLC13A1 protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	16729303
D000082	Acetaminophen	Taurine inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]	20166895
D000082	Acetaminophen	Taurine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	20067817
D000082	Acetaminophen	tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	30423402
D000082	Acetaminophen	tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	30423402
D000082	Acetaminophen	[Acetaminophen co-treated with Uranium analog] results in decreased expression of CYP2E1 mRNA	17126469
D000082	Acetaminophen	Acetaminophen results in decreased expression of CYP2E1 mRNA	17126469; 21807079;
D000082	Acetaminophen	Acetaminophen results in increased activity of CYP2E1 protein	19932728
D000082	Acetaminophen	Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein	21170329
D000082	Acetaminophen	Acetaminophen results in increased expression of CYP2E1 protein	18798224
D000082	Acetaminophen	Acetaminophen results in increased phosphorylation of and results in increased activity of CYP2E1 protein	11562448
D000082	Acetaminophen	Arsenic inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]	19932728
D000082	Acetaminophen	Choline deficiency promotes the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	18798224
D000082	Acetaminophen	CYP2E1 protein affects the metabolism of Acetaminophen	15772367
D000082	Acetaminophen	CYP2E1 protein results in increased susceptibility to Acetaminophen	21130154
D000082	Acetaminophen	[Isoniazid results in increased expression of CYP2E1] which results in increased metabolism of Acetaminophen	20566340
D000082	Acetaminophen	Uranium analog promotes the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	17126469
D000082	Acetaminophen	YH 439 inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of CYP2E1 protein]	11562448
D000082	Acetaminophen	Acetaminophen results in increased expression of CYP2E1 protein	20166895
D000082	Acetaminophen	Buthionine Sulfoximine promotes the reaction [CYP2E1 protein affects the oxidation of Acetaminophen]	20404090
D000082	Acetaminophen	CYP2E1 protein affects the metabolism of and results in decreased abundance of Acetaminophen	20166895
D000082	Acetaminophen	CYP2E1 protein affects the oxidation of Acetaminophen	20404090
D000082	Acetaminophen	CYP2E1 protein results in increased metabolism of Acetaminophen	20423716; 23628456;
D000082	Acetaminophen	CYP2E1 results in increased metabolism of Acetaminophen	20566340
D000082	Acetaminophen	Taurine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	20166895
D019342	Acetic Acid	CYP2E1 protein results in increased metabolism of Acetic Acid analog	21933969
D000096	Acetone	CYP2E1 protein results in increased metabolism of Acetone	15576447
D000096	Acetone	[Acetone results in increased activity of CYP2E1 protein] which results in increased oxidation of Benzene	8560479
D000096	Acetone	Acetone results in increased expression of and results in increased activity of CYP2E1 protein	8013281
D000096	Acetone	Acetone results in increased expression of CYP2E1 mRNA	22499231
D000096	Acetone	Acetone results in increased expression of CYP2E1 protein	18990727
D000096	Acetone	[Acetone results in increased expression of CYP2E1 protein] which results in increased susceptibility to allyl cyanide	18990727
D000096	Acetone	Acetone results in increased activity of CYP2E1 protein	8471070
D000096	Acetone	Acetone results in increased expression of CYP2E1 mRNA	8471070
D000096	Acetone	Acetone results in increased expression of CYP2E1 protein	8471070
D000096	Acetone	Alpha-Amanitin inhibits the reaction [Acetone results in increased expression of CYP2E1 mRNA]	8471070
D000096	Acetone	1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]	9851676
D000096	Acetone	[Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein	7587954
D000096	Acetone	[Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA	8734847
D000096	Acetone	[Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein	8734847
D000096	Acetone	[Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein	8734847
D000096	Acetone	[Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein	8734847
D000096	Acetone	Acetone promotes the reaction [2-xylene results in increased expression of CYP2E1 protein]	8996725
D000096	Acetone	Acetone promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	8267643
D000096	Acetone	Acetone promotes the reaction [Toluene results in increased expression of CYP2E1 protein]	8996725
D000096	Acetone	Acetone results in increased activity of CYP2E1 protein	12919724; 20127315; 3782137; 8734847; 9851676;
D000096	Acetone	Acetone results in increased expression of CYP2E1 mRNA	11939710; 2241968; 8267643;
D000096	Acetone	Acetone results in increased expression of CYP2E1 protein	11939710; 12919724; 15763544; 1968335; 2241968; 3416296; 3782137; 8117100; 8267643; 8734847;
D000096	Acetone	Trichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]	9851676
D000096	Acetone	Acetone results in increased activity of CYP2E1 protein	8560479
C032159	acetonitrile	acetonitrile inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
C032159	acetonitrile	acetonitrile inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]	19858067
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	30423402
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	30423402
D000111	Acetylcysteine	[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP2E1 protein]	21424224
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]	23159886
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	23159886
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CYP2E1 mRNA]	23159886
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]	26332274
D000111	Acetylcysteine	[CYP2E1 protein co-treated with Acetylcysteine] affects the metabolism of Isoquinolines	21395287
D020106	Acrylamide	Acrylamide affects the expression of CYP2E1 mRNA	17267090
D020106	Acrylamide	Acrylamide results in increased expression of CYP2E1 protein	24508477
D020106	Acrylamide	Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]	24508477
D020106	Acrylamide	[CYP2E1 gene polymorphism co-treated with GSTM1 gene polymorphism] affects the metabolism of Acrylamide	19131562
D020106	Acrylamide	[CYP2E1 gene polymorphism co-treated with GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Acrylamide	19131562
D020106	Acrylamide	CYP2E1 intron polymorphism affects the metabolism of Acrylamide	29748789
D020106	Acrylamide	CYP2E1 protein affects the susceptibility to Acrylamide	24508477
D020106	Acrylamide	epigallocatechin gallate inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]	24508477
D020106	Acrylamide	CYP2E1 protein affects the metabolism of Acrylamide	17979661
D020106	Acrylamide	CYP2E1 protein results in increased oxidation of Acrylamide	15355880
D020106	Acrylamide	[CYP2E1 protein results in increased oxidation of Acrylamide] which results in increased abundance of glycidamide	27174446
D020106	Acrylamide	CYP2E1 protein results in increased susceptibility to Acrylamide	15355880; 17267090;
D020106	Acrylamide	Acrylamide affects the expression of CYP2E1 mRNA	28959563
D020106	Acrylamide	Acrylamide results in increased expression of CYP2E1 mRNA	28606764
D020106	Acrylamide	CYP2E1 protein affects the metabolism of Acrylamide	21978862
D020106	Acrylamide	CYP2E1 protein results in increased metabolism of Acrylamide	25980586; 26783003;
D020106	Acrylamide	[CYP2E1 protein results in increased metabolism of Acrylamide] which results in increased chemical synthesis of glycidamide	25980586
D000181	Acrylonitrile	CYP2E1 protein results in increased oxidation of Acrylonitrile	1664256
D000181	Acrylonitrile	Acetylcysteine promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]	26332274
D000181	Acrylonitrile	Acrylonitrile inhibits the reaction [[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene]	9010585
D000181	Acrylonitrile	Acrylonitrile results in increased expression of CYP2E1 mRNA	26332274
D000181	Acrylonitrile	alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]	26332274
D000181	Acrylonitrile	CYP2E1 protein affects the susceptibility to Acrylonitrile	20127315
D000181	Acrylonitrile	Plant Extracts promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]	26332274
C058956	acteoside	acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]	14672760
C116917	acylcarnitine	CYP2E1 protein affects the reaction [Acetaminophen results in increased abundance of acylcarnitine]	19256530
D000336	Aerosols	Aerosols results in increased expression of CYP2E1 mRNA	29505817
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CYP2E1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CYP2E1 mRNA	22100608; 27153756;
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CYP2E1 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CYP2E1 mRNA	23630614
D016604	Aflatoxin B1	CYP2E1 protein results in increased oxidation of Aflatoxin B1	25154877
D016604	Aflatoxin B1	[CYP2E1 protein results in increased oxidation of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide	25154877
C006426	aflatoxin B1-2,3-oxide	CYP2E1 protein results in increased chemical synthesis of aflatoxin B1-2,3-oxide	25154877
C006426	aflatoxin B1-2,3-oxide	[CYP2E1 protein results in increased oxidation of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide	25154877
D000438	Alcohols	Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP2E1 mRNA]	24025710
D000438	Alcohols	Alcohols results in increased activity of CYP2E1 protein	24025710
D000438	Alcohols	Alcohols results in increased expression of CYP2E1 mRNA	24025710
D000438	Alcohols	ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP2E1 mRNA]	24025710
D000438	Alcohols	Alcohols results in increased expression of CYP2E1 protein	28803762
D000438	Alcohols	Apigenin inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein]	28803762
D000438	Alcohols	Glutathione inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein]	28803762
C010078	alizarin	alizarin results in decreased activity of CYP2E1 protein	12379470
D000470	Alkaloids	Alkaloids inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	21224420
D000470	Alkaloids	Alkaloids inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	21224420
D000487	Allethrins	Allethrins results in increased expression of and results in increased activity of CYP2E1 protein	22080754
D000496	Alloxan	Alloxan affects the reaction [CYP2E1 protein results in decreased methylation of Dimethylnitrosamine]	17034923
D000496	Alloxan	Alloxan results in increased expression of CYP2E1 protein	17034923
C006463	allyl alcohol	allyl alcohol results in increased expression of CYP2E1 protein	11515535
C015660	allyl cyanide	[Acetone results in increased expression of CYP2E1 protein] which results in increased susceptibility to allyl cyanide	18990727
C015660	allyl cyanide	CYP2E1 protein results in increased susceptibility to allyl cyanide	22051853
C077207	allyl methyl sulfide	allyl methyl sulfide results in decreased expression of CYP2E1 protein	16000231; 8117321;
C038491	allyl sulfide	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]	12086689
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	22138249
C038491	allyl sulfide	allyl sulfide results in decreased activity of CYP2E1 protein	15974642; 17034788; 18339364;
C038491	allyl sulfide	allyl sulfide inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 mRNA]	21684301
C038491	allyl sulfide	allyl sulfide inhibits the reaction [ethylene dichloride results in increased expression of CYP2E1 protein]	27301210
C038491	allyl sulfide	allyl sulfide inhibits the reaction [1-bromopropane results in increased expression of CYP2E1]	30247689
C038491	allyl sulfide	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of 2,2-dichloro-1,1,1-trifluoroethane]	7956723
C038491	allyl sulfide	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]	7601153; 8117321;
C038491	allyl sulfide	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of aniline]	8117321
C038491	allyl sulfide	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]	7601153
C038491	allyl sulfide	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]	8117321
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Diethylnitrosamine results in decreased expression of and results in decreased activity of CYP2E1 protein]	23494807
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Diethylnitrosamine results in decreased expression of CYP2E1 mRNA]	23494807
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	20116195
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Pyrazines results in increased activity of CYP2E1 protein]	8117321
C038491	allyl sulfide	allyl sulfide inhibits the reaction [Pyrazines results in increased expression of CYP2E1 protein]	8117321
C038491	allyl sulfide	allyl sulfide results in decreased activity of CYP2E1 protein	30247689; 7956723;
C038491	allyl sulfide	allyl sulfide results in decreased expression of CYP2E1 protein	16000231; 7601153; 8117321;
C038491	allyl sulfide	allyl sulfide results in increased activity of CYP2E1 protein	15046820
C038491	allyl sulfide	allyl sulfide results in increased expression of CYP2E1 protein	8627517
C038491	allyl sulfide	allyl sulfide results in decreased activity of CYP2E1 protein	12060674; 12086689; 20116195; 20615459; 22530035; 9877205;
D053959	Alpha-Amanitin	Alpha-Amanitin inhibits the reaction [Acetone results in increased expression of CYP2E1 mRNA]	8471070
C010177	alpha-hederin	alpha-hederin results in decreased activity of CYP2E1 protein	9861456
C040534	alpha-hexachlorocyclohexane	[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2E1 protein	16246485
D017962	alpha-Linolenic Acid	alpha-Linolenic Acid results in decreased activity of CYP2E1 protein	16978661
D024502	alpha-Tocopherol	alpha-Tocopherol results in increased expression of CYP2E1 mRNA	28062356
D024502	alpha-Tocopherol	alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]	26332274
D024502	alpha-Tocopherol	alpha-Tocopherol results in increased expression of CYP2E1 mRNA	26332274
D024502	alpha-Tocopherol	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D024502	alpha-Tocopherol	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D000638	Amiodarone	CYP2E1 protein results in decreased susceptibility to Amiodarone	26477383
C014983	amitraz	amitraz results in increased expression of CYP2E1 protein	31029719
D000640	Amitrole	Amitrole results in decreased activity of CYP2E1 protein	12464242
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CYP2E1 mRNA	16483693
D000667	Ampicillin	[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2E1 mRNA	30545405
D000728	Androgens	Androgens results in decreased expression of CYP2E1 protein	2785912
D000737	Androstenols	Androstenols results in decreased expression of CYP2E1 mRNA	17962186
C011659	angelicin	angelicin results in decreased expression of CYP2E1 protein	22173200
C023650	aniline	aniline results in decreased activity of CYP2E1 protein	12814958; 15306208;
C023650	aniline	CYP2E1 protein affects the metabolism of [norharman co-treated with aniline]	15279827
C023650	aniline	CYP2E1 protein results in increased hydroxylation of aniline	8858968; 9195021;
C023650	aniline	CYP2E1 protein results in increased metabolism of aniline	12464242; 8819299;
C023650	aniline	Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of aniline]	8074729
C023650	aniline	Proadifen inhibits the reaction [CYP2E1 protein results in increased metabolism of aniline]	8819299
C023650	aniline	CYP2E1 protein results in increased hydroxylation of aniline	9195021
C023650	aniline	caffeic acid phenethyl ester inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]	18436364
C023650	aniline	Changkil inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]	18291569
C023650	aniline	CYP2E1 protein results in increased hydroxylation of aniline	18038910; 18291569; 18436364;
C023650	aniline	puerarin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]	18038910
C023650	aniline	[CYP2E1 protein co-treated with POR protein] results in increased hydroxylation of aniline	2292581
C023650	aniline	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of aniline]	8117321
C023650	aniline	[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of aniline	9010585
C023650	aniline	CYP2E1 protein results in increased hydroxylation of aniline	23274713
C023650	aniline	CYP2E1 protein results in increased metabolism of aniline	26463279
C023650	aniline	Ethanol promotes the reaction [CYP2E1 protein results in increased hydroxylation of aniline]	23274713
C023650	aniline	Genistein inhibits the reaction [Ethanol promotes the reaction [CYP2E1 protein results in increased hydroxylation of aniline]]	23274713
C023650	aniline	[Grape Seed Proanthocyanidins results in decreased activity of CYP2E1 protein] which results in decreased hydroxylation of aniline	11330834
D000872	Anthocyanins	Anthocyanins results in increased expression of CYP2E1 mRNA	18803703
C553458	apatinib	apatinib affects the activity of CYP2E1 protein	30138636
C553458	apatinib	apatinib results in decreased activity of CYP2E1 protein	30138636
D047310	Apigenin	Apigenin results in decreased activity of CYP2E1 protein	29753067
D047310	Apigenin	Apigenin inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein]	28803762
D016718	Arachidonic Acid	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]	12086689
D016718	Arachidonic Acid	[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein	17034788
D016718	Arachidonic Acid	[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein	17034788
D016718	Arachidonic Acid	[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein	17034788
D016718	Arachidonic Acid	Arachidonic Acid results in decreased activity of CYP2E1 protein	16978661
D016718	Arachidonic Acid	Cadmium Chloride affects the reaction [CYP2E1 protein results in increased susceptibility to Arachidonic Acid]	12566070
D016718	Arachidonic Acid	CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]	12086689; 21352821;
D016718	Arachidonic Acid	CYP2E1 results in increased susceptibility to Arachidonic Acid	12566070
D016718	Arachidonic Acid	CYP2E1 results in increased susceptibility to [Arachidonic Acid co-treated with Zinc Sulfate]	12566070
D016718	Arachidonic Acid	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]	12086689
D016718	Arachidonic Acid	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]	12086689
D016718	Arachidonic Acid	Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Arachidonic Acid]	12566070
D016718	Arachidonic Acid	CYP2E1 protein affects the hydroxylation of Arachidonic Acid	15205388
D001115	Arecoline	Arecoline analog results in increased activity of CYP2E1 protein	25056785
D001151	Arsenic	Arsenic affects the expression of CYP2E1 mRNA	18414638
D001151	Arsenic	Arsenic inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]	19932728
D001151	Arsenic	Arsenic results in decreased activity of CYP2E1 protein	19932728
D000077237	Arsenic Trioxide	Arsenic Trioxide affects the expression of CYP2E1 mRNA	17530438
C031327	artemisinine	artemisinine results in increased expression of CYP2E1 mRNA	17962186
D017636	Asbestos, Amphibole	Asbestos, Amphibole affects the expression of CYP2E1 protein	20855422
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with Ethanol] results in decreased expression of CYP2E1 mRNA	22149461
D001205	Ascorbic Acid	Ascorbic Acid results in decreased activity of CYP2E1 protein	17512695
C017032	asiatic acid	asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein]	29108773
C022870	asoxime chloride	asoxime chloride results in decreased activity of CYP2E1 protein	19539805
D001218	Aspartame	Aspartame results in increased expression of and results in increased activity of CYP2E1 protein	16937917
D001241	Aspirin	Aspirin results in increased expression of CYP2E1 mRNA	11752103
D001280	Atrazine	Atrazine results in increased expression of CYP2E1 mRNA	26775023
D001280	Atrazine	Lycopene inhibits the reaction [Atrazine results in increased expression of CYP2E1 mRNA]	26775023
D001280	Atrazine	Atrazine results in increased expression of CYP2E1 protein	14961354
C547126	AZM551248	AZM551248 results in increased expression of CYP2E1 mRNA	22323515
D001397	Azoxymethane	Azoxymethane results in decreased expression of CYP2E1 mRNA	18038451
C006680	baicalein	baicalein results in decreased activity of CYP2E1 protein	29753067
C447119	bazedoxifene	CYP2E1 protein results in increased glutathionylation of bazedoxifene	22429462
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of CYP2E1 mRNA	26377693
D001554	Benzene	Benzene results in decreased methylation of CYP2E1 promoter	28823944
D001554	Benzene	Benzene results in increased expression of CYP2E1 mRNA	18952161
D001554	Benzene	CYP2E1 gene polymorphism affects the susceptibility to Benzene	15226677; 16737589; 17095285;
D001554	Benzene	CYP2E1 gene polymorphism results in increased susceptibility to Benzene	15226677
D001554	Benzene	CYP2E1 gene SNP affects the susceptibility to Benzene	21784317
D001554	Benzene	CYP2E1 protein affects the metabolism of Benzene	15051535; 15226677;
D001554	Benzene	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of catechol	15051535
D001554	Benzene	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of hydroquinone	15051535
D001554	Benzene	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of hydroxyhydroquinone	15051535
D001554	Benzene	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of muconic acid	15051535
D001554	Benzene	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of Phenol	15051535
D001554	Benzene	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of S-phenyl-N-acetylcysteine	15051535
D001554	Benzene	CYP2E1 protein affects the susceptibility to Benzene	12460800; 8987251;
D001554	Benzene	CYP2E1 protein alternative form results in increased hydroxylation of Benzene	20033806
D001554	Benzene	CYP2E1 protein results in increased hydroxylation of Benzene	15122651; 20033806;
D001554	Benzene	CYP2E1 protein results in increased metabolism of Benzene	17885617; 18350910; 9817075;
D001554	Benzene	CYP2E1 protein results in increased oxidation of Benzene	10207612; 1664256; 9118895; 9817075;
D001554	Benzene	[Acetone results in increased activity of CYP2E1 protein] which results in increased oxidation of Benzene	8560479
D001554	Benzene	AHR protein affects the reaction [Benzene results in increased expression of CYP2E1 protein]	12388843
D001554	Benzene	Benzene results in decreased activity of CYP2E1 protein	8751834
D001554	Benzene	[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of 2-dichlorobenzene	9817075
D001554	Benzene	Benzene results in increased expression of CYP2E1 mRNA	12928149; 17157166; 30567741;
D001554	Benzene	Benzene results in increased expression of CYP2E1 protein	12388843; 30567741;
D001554	Benzene	CYP2E1 protein affects the susceptibility to Benzene	8560479
D001554	Benzene	CYP2E1 protein results in increased hydroxylation of Benzene	11718959; 14718178;
D001554	Benzene	CYP2E1 protein results in increased metabolism of Benzene	11376689; 8461037;
D001554	Benzene	CYP2E1 protein results in increased oxidation of Benzene	8560479
D001554	Benzene	CYP2E1 protein results in increased susceptibility to Benzene	8917693
D001554	Benzene	dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of 2-dichlorobenzene]	9817075
D001554	Benzene	[Ditiocarb results in decreased activity of CYP2E1 protein] which results in decreased oxidation of Benzene	8560479
D001554	Benzene	PPP2R1A protein affects the reaction [Benzene results in increased expression of CYP2E1 mRNA]	30567741
D001554	Benzene	PPP2R1A protein affects the reaction [Benzene results in increased expression of CYP2E1 protein]	30567741
D001554	Benzene	[Toluene co-treated with Benzene] results in increased activity of CYP2E1 protein	18455711
D001554	Benzene	CYP2E1 protein results in increased metabolism of Benzene	3416296
D001554	Benzene	Acrylonitrile inhibits the reaction [[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene]	9010585
D001554	Benzene	Benzene affects the expression of CYP2E1 mRNA	15878777
D001554	Benzene	Benzene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]	8889796
D001554	Benzene	Benzene results in decreased activity of CYP2E1 protein	18407866
D001554	Benzene	Benzene results in decreased expression of CYP2E1 protein	15274493
D001554	Benzene	Benzene results in increased activity of CYP2E1 protein	12919724; 20338863; 8620572; 8889796;
D001554	Benzene	[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene	9817075
D001554	Benzene	Benzene results in increased expression of CYP2E1 mRNA	12919724
D001554	Benzene	Benzene results in increased expression of CYP2E1 protein	12919724; 3416296; 8517779; 8620572; 9010585; 9118895;
D001554	Benzene	[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of aniline	9010585
D001554	Benzene	[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene	9010585
D001554	Benzene	[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of chlorobenzene	9010585
D001554	Benzene	[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Toluene	9010585
D001554	Benzene	CYP2E1 protein affects the reaction [Benzene results in increased metabolism of Toluene]	8620572
D001554	Benzene	CYP2E1 protein affects the susceptibility to Benzene	9118891
D001554	Benzene	CYP2E1 protein results in increased metabolism of Benzene	1739413; 3416296; 8211999; 8461037;
D001554	Benzene	[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone	8211999
D001554	Benzene	[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of Phenol	8211999
D001554	Benzene	CYP2E1 protein results in increased oxidation of Benzene	9118895
D001554	Benzene	dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene]	9817075
D001554	Benzene	Ditiocarb inhibits the reaction [[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene]	9010585
D001554	Benzene	EPHX1 protein promotes the reaction [CYP2E1 protein results in increased metabolism of Benzene]	8211999
D001554	Benzene	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of Benzene metabolite]	8211999
D001554	Benzene	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone]	8211999
D001554	Benzene	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of Phenol]	8211999
D001554	Benzene	Melatonin inhibits the reaction [Benzene results in increased activity of CYP2E1 protein]	20338863
D001554	Benzene	[Methylcholanthrene results in decreased expression of CYP2E1 protein] which affects the metabolism of Benzene	9118891
D001554	Benzene	Progesterone promotes the reaction [Benzene results in decreased activity of CYP2E1 protein]	18407866
D001554	Benzene	CYP2E1 protein affects the metabolism of Benzene	10447556
D001554	Benzene	CYP2E1 protein results in increased metabolism of Benzene	15833037
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CYP2E1 mRNA	16269432
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of CYP2E1 gene	25435355
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CYP2E1 mRNA	19770486; 20127859;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CYP2E1 mRNA	19889059; 21383588;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CYP2E1 protein	19889059; 21383588;
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of CYP2E1 mRNA	16269432
D001589	Benzphetamine	[CYP2E1 protein co-treated with POR protein] results in decreased methylation of Benzphetamine	2292581
D019905	Benzyl Alcohol	CYP2E1 protein affects the metabolism of Benzyl Alcohol	8592870
D001592	Benzyl Alcohols	CYP2E1 protein results in increased oxidation of Benzyl Alcohols	7515681
C025383	benzylideneacetone	CYP2E1 protein results in increased oxidation of benzylideneacetone	15863696
D001599	Berberine	Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	25455889
D001599	Berberine	Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]	22342832
D001599	Berberine	Berberine results in decreased expression of CYP2E1 mRNA	22342832
D001622	Betaine	Betaine promotes the reaction [Ethanol results in increased expression of CYP2E1]	21352821
D001622	Betaine	[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	20118189
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of CYP2E1 mRNA	22258563
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of CYP2E1 mRNA	30373287
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of CYP2E1 protein	30373287
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of CYP2E1 mRNA	19969063
D019324	beta-Naphthoflavone	[Phenobarbital co-treated with beta-Naphthoflavone] results in decreased expression of CYP2E1 protein	30842367
D000077610	Bexarotene	Bexarotene analog results in increased expression of CYP2E1 mRNA	28689802
C477843	bicyclol	bicyclol inhibits the reaction [Tetracycline results in decreased expression of CYP2E1 mRNA]	19427351
C477843	bicyclol	bicyclol results in increased activity of CYP2E1 protein	15998439
C099952	bifenthrin	bifenthrin results in increased expression of CYP2E1 mRNA	26071804
C073710	bilobalide	bilobalide results in increased activity of CYP2E1 protein	18421621
D001710	Biotin	Biotin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
C006780	bisphenol A	CYP2E1 protein results in increased glutathionylation of bisphenol A metabolite	23470418
C006780	bisphenol A	CYP2E1 protein results in increased hydroxylation of bisphenol A	23470418
C006780	bisphenol A	CYP2E1 protein results in increased hydroxylation of bisphenol A metabolite	23470418
C006780	bisphenol A	CYP2E1 protein results in increased susceptibility to bisphenol A	27491884
C006780	bisphenol A	bisphenol A results in increased expression of CYP2E1 mRNA	30245210
C006780	bisphenol A	bisphenol A results in increased methylation of CYP2E1 promoter	27312807
C006780	bisphenol A	[LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of CYP2E1 mRNA	28123100
C006780	bisphenol A	bisphenol A affects the expression of CYP2E1 mRNA	25181051; 30903817;
C006780	bisphenol A	bisphenol A results in decreased expression of CYP2E1 mRNA	26794494
D001786	Blood Glucose	Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]	26747958
D001786	Blood Glucose	Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]	26747958
D001786	Blood Glucose	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA]	26747958
D001786	Blood Glucose	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein]	26747958
D001786	Blood Glucose	Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]	26747958
D001786	Blood Glucose	Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]	26747958
D001786	Blood Glucose	[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 mRNA	26747958
D001786	Blood Glucose	[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 protein	26747958
D001786	Blood Glucose	[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA	26747958
D001786	Blood Glucose	[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein	26747958
D001786	Blood Glucose	[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA	26747958
D001786	Blood Glucose	[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein	26747958
D001786	Blood Glucose	zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]	26747958
D001786	Blood Glucose	zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]	26747958
C021636	bromadiolone	bromadiolone results in increased expression of CYP2E1 mRNA	18080289
C021636	bromadiolone	CYP2E1 protein results in decreased susceptibility to bromadiolone	18080289
C032036	bromobenzene	bromobenzene results in increased expression of CYP2E1 protein	10547960
C032036	bromobenzene	bromobenzene results in increased expression of CYP2E1 mRNA	12628495
C025191	bromodichloromethane	CYP2E1 protein results in increased metabolism of bromodichloromethane	12076521; 12076522; 18350910;
C025191	bromodichloromethane	CYP2E1 gene mutant form results in decreased susceptibility to bromodichloromethane	23640861
C025191	bromodichloromethane	CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA]	24211274
C025191	bromodichloromethane	CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA]	24211274
C025191	bromodichloromethane	CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]	24211274
C025191	bromodichloromethane	CYP2E1 protein affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats]	24211274
C025191	bromodichloromethane	[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CYP2E1 protein	23438451
C025191	bromodichloromethane	bromodichloromethane results in increased expression of CYP2E1 protein	11295256
C025191	bromodichloromethane	CYP2E1 protein results in increased metabolism of and results in increased activity of bromodichloromethane	9458004
C025191	bromodichloromethane	CYP2E1 protein results in increased metabolism of bromodichloromethane	11295256; 12076521;
C025191	bromodichloromethane	CYP2E1 protein results in increased metabolism of bromodichloromethane	23438451
C025191	bromodichloromethane	[CYP2E1 protein results in increased metabolism of bromodichloromethane] which results in increased expression of LEP protein	23438451
C083806	brucine	[brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein	21800547
C083806	brucine	[brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein	21800547
C083806	brucine	brucine results in increased activity of CYP2E1 protein	21800547
D003994	Bucladesine	Bucladesine promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine promotes the reaction [CYP2E1 protein results in increased expression of COL1A2 mRNA]	10498651
D019328	Buthionine Sulfoximine	CYP2E1 protein results in increased susceptibility to Buthionine Sulfoximine	12086689
D019328	Buthionine Sulfoximine	CYP2E1 results in increased susceptibility to Buthionine Sulfoximine	12566070
D019328	Buthionine Sulfoximine	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin promotes the reaction [CYP2E1 protein results in increased susceptibility to Buthionine Sulfoximine]	12086689
D019328	Buthionine Sulfoximine	Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Buthionine Sulfoximine]	12566070
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine promotes the reaction [CYP2E1 protein affects the oxidation of Acetaminophen]	20404090
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased activity of CYP2E1 protein	27432241
C038091	butylparaben	butylparaben results in decreased activity of CYP2E1 protein	27432241
D002104	Cadmium	Cadmium results in increased expression of CYP2E1 mRNA	21120746
D019256	Cadmium Chloride	Cadmium Chloride affects the reaction [CYP2E1 protein results in increased susceptibility to Arachidonic Acid]	12566070
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CYP2E1 mRNA	11958953
C053400	cafestol	cafestol results in decreased activity of CYP2E1 protein	17590492
C040048	caffeic acid	caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]	18436364
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CYP2E1 mRNA	20360939
D002110	Caffeine	CYP2E1 protein affects the metabolism of Caffeine	1302044; 14586387;
D002118	Calcium	CYP2E1 protein results in decreased uptake of Calcium	19028543
D002118	Calcium	Calcium affects the expression of CYP2E1 mRNA	15913539
C004645	canadine	canadine results in increased expression of CYP2E1 mRNA	28257954
C004645	canadine	canadine results in increased expression of CYP2E1 protein	28257954
D002211	Capsaicin	Capsaicin results in increased expression of CYP2E1	22375877
D002220	Carbamazepine	Carbamazepine results in decreased expression of CYP2E1 mRNA	17381134
D012721	Carbaryl	Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D012721	Carbaryl	Carbaryl results in decreased activity of CYP2E1 protein	22634058
D002248	Carbon Monoxide	Carbon Monoxide results in decreased activity of CYP2E1 protein	15036350
D002248	Carbon Monoxide	Carbon Monoxide inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)]	1903091
D002251	Carbon Tetrachloride	Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136; 9143349;
D002251	Carbon Tetrachloride	Carbon Tetrachloride promotes the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased activity of CYP2E1 protein	17710613
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased degradation of and results in decreased activity of CYP2E1 protein	8531136
D002251	Carbon Tetrachloride	Cycloheximide promotes the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]	8531136
D002251	Carbon Tetrachloride	CYP2E1 protein results in increased metabolism of Carbon Tetrachloride	15797236; 18350910; 8531136;
D002251	Carbon Tetrachloride	Dimethylnitrosamine inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
D002251	Carbon Tetrachloride	Dimethylnitrosamine inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]	8531136
D002251	Carbon Tetrachloride	Ethanol inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
D002251	Carbon Tetrachloride	Fomepizole inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
D002251	Carbon Tetrachloride	Fomepizole inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]	8531136
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of CYP2E1 mRNA	30517762
D002251	Carbon Tetrachloride	Carbon Tetrachloride promotes the reaction [Tamoxifen results in decreased expression of CYP2E1 mRNA]	29974145
D002251	Carbon Tetrachloride	Carbon Tetrachloride promotes the reaction [Tamoxifen results in decreased expression of CYP2E1 protein]	29974145
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased activity of CYP2E1 protein	17038628; 19793341; 29974145;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein	15983038
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA	12759355; 15056808; 15962327; 18038451; 19393728; 25270620; 25566828; 26443840; 29974145; 29987408;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CYP2E1 protein	12466116; 15962327; 16445600; 19393728; 19913046; 25566828; 25656916; 26443840; 29974145;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased activity of CYP2E1 protein	25445725
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein	10355542
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CYP2E1 mRNA	29964319
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CYP2E1 protein	17610925; 23279844; 23994094; 26218279;
D002251	Carbon Tetrachloride	CDKN1A protein affects the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]	12759355
D002251	Carbon Tetrachloride	CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of BNIP3 mRNA]	17084009
D002251	Carbon Tetrachloride	CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAR3 mRNA]	17084009
D002251	Carbon Tetrachloride	CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP1A2 mRNA]	17084009
D002251	Carbon Tetrachloride	CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL1RAP mRNA]	17084009
D002251	Carbon Tetrachloride	CYP2E1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in decreased expression of PAH mRNA]	17084009
D002251	Carbon Tetrachloride	CYP2E1 protein affects the susceptibility to Carbon Tetrachloride	15962327
D002251	Carbon Tetrachloride	Flavonoids inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	23279844
D002251	Carbon Tetrachloride	ginsan promotes the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]	19913046
D002251	Carbon Tetrachloride	ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	29964319
D002251	Carbon Tetrachloride	Lipids inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]	25445725
D002251	Carbon Tetrachloride	Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]	25566828
D002251	Carbon Tetrachloride	Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]	25566828
D002251	Carbon Tetrachloride	myricitrin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]	25656916
D002251	Carbon Tetrachloride	NUPR1 protein affects the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]	15962327
D002251	Carbon Tetrachloride	NUPR1 protein affects the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]	15962327
D002251	Carbon Tetrachloride	Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]	10355542
D002251	Carbon Tetrachloride	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	23279844; 23994094;
D002251	Carbon Tetrachloride	Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	26218279
D002251	Carbon Tetrachloride	rossicaside B inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2E1 protein]	19793341
D002251	Carbon Tetrachloride	S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein]	15983038
D002251	Carbon Tetrachloride	Saponins inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	23994094
D002251	Carbon Tetrachloride	Tamoxifen inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]	29974145
D002251	Carbon Tetrachloride	Tamoxifen inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]	29974145
D002251	Carbon Tetrachloride	Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)]	1903091
D002251	Carbon Tetrachloride	acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]	14672760
D002251	Carbon Tetrachloride	Alkaloids inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	21224420
D002251	Carbon Tetrachloride	Alkaloids inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	21224420
D002251	Carbon Tetrachloride	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]	7601153
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of CYP2E1 mRNA	17805973
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased activity of CYP2E1 protein	14706259; 16288784; 17410408;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA	14706259; 25450236; 27623180; 31150632;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CYP2E1 protein	17606319; 25450236; 31168027;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased activity of CYP2E1 protein	17710613; 25899501;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased degradation of CYP2E1 protein	12679053
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein	14672760
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CYP2E1 mRNA	11903743; 21224420; 24582681; 29129047;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CYP2E1 protein	21224420
D002251	Carbon Tetrachloride	Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]	7601153
D002251	Carbon Tetrachloride	crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]	25899501
D002251	Carbon Tetrachloride	CYP2E1 protein affects the metabolism of Carbon Tetrachloride	15772367
D002251	Carbon Tetrachloride	CYP2E1 protein results in increased metabolism of Carbon Tetrachloride	7601153
D002251	Carbon Tetrachloride	Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	24582681
D002251	Carbon Tetrachloride	ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	11903743
D002251	Carbon Tetrachloride	Ethanol promotes the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]	7601153
D002251	Carbon Tetrachloride	isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]	25450236
D002251	Carbon Tetrachloride	isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]	25450236
D002251	Carbon Tetrachloride	phenethyl isothiocyanate inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]	7601153
D002251	Carbon Tetrachloride	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	21224420; 29129047;
D002251	Carbon Tetrachloride	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	21224420
D002251	Carbon Tetrachloride	Propolis inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2E1 protein]	17410408
D002251	Carbon Tetrachloride	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]	31150632
D002251	Carbon Tetrachloride	Silymarin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2E1 protein]	17410408
D002251	Carbon Tetrachloride	Silymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	24582681; 29129047;
D002251	Carbon Tetrachloride	CYP2E1 protein results in increased metabolism of and results in increased activity of Carbon Tetrachloride	16142352
D002251	Carbon Tetrachloride	CYP2E1 protein results in increased metabolism of Carbon Tetrachloride	15962327
D002251	Carbon Tetrachloride	[CYP2E1 protein results in increased metabolism of Carbon Tetrachloride] which results in increased abundance of trichloromethyl free radical	19336974
D002331	Carnitine	Carnitine promotes the reaction [Ethanol results in increased expression of CYP2E1 protein]	8130774
D002336	Carnosine	Carnosine inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]	19799668
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CYP2E1 mRNA	24763279
D002392	Catechin	Catechin inhibits the reaction [Ethanol results in increased expression of CYP2E1]	21352821
C034221	catechol	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of catechol	15051535
C034221	catechol	[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of catechol	8211999
C034221	catechol	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of catechol]	8211999
C088453	Celsior	Celsior results in decreased activity of CYP2E1 protein	15448115
C088453	Celsior	Celsior results in decreased expression of CYP2E1 mRNA	15448115
C440574	Changkil	Changkil inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]	18291569
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased expression of CYP2E1 mRNA	27174168
C473711	Chir 99021	Chir 99021 results in increased expression of and results in increased activity of CYP2E1 protein	26259606
C473711	Chir 99021	Chir 99021 results in increased expression of CYP2E1 mRNA	26259606
D002697	Chloral Hydrate	CYP2E1 protein results in increased chemical synthesis of Chloral Hydrate	1739413
D002697	Chloral Hydrate	[CYP2E1 protein results in increased metabolism of Trichloroethylene] which results in increased chemical synthesis of Chloral Hydrate	1739413
C057223	chlorfluazuron	chlorfluazuron inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
C057223	chlorfluazuron	chlorfluazuron results in decreased activity of CYP2E1 protein	22634058
D002719	Chlormethiazole	Chlormethiazole inhibits the reaction [Docosahexaenoic Acids results in increased expression of CYP2E1 protein]	16963249
D002719	Chlormethiazole	Chlormethiazole results in decreased activity of CYP2E1 protein	26599973
D002719	Chlormethiazole	[Chlormethiazole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002719	Chlormethiazole	Chlormethiazole results in decreased expression of CYP2E1 protein	16963249
D002719	Chlormethiazole	Chlormethiazole inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 mRNA]	21684301
D002719	Chlormethiazole	Chlormethiazole inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	22552773
D002719	Chlormethiazole	Chlormethiazole inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	24892905
D002719	Chlormethiazole	Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]	7601153
D002719	Chlormethiazole	Chlormethiazole inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]	7601153
D002719	Chlormethiazole	Chlormethiazole results in decreased activity of CYP2E1 protein	16330492
D002719	Chlormethiazole	Chlormethiazole results in decreased expression of CYP2E1 mRNA	10751552
D002719	Chlormethiazole	Chlormethiazole results in decreased expression of CYP2E1 protein	10751552; 7601153;
D002719	Chlormethiazole	Chlormethiazole results in decreased activity of CYP2E1 protein	16054987
C031294	chlorobenzene	CYP2E1 protein results in increased oxidation of chlorobenzene	9817075
C031294	chlorobenzene	dihydroxyethyldithiocarbamate inhibits the reaction [CYP2E1 protein results in increased metabolism of chlorobenzene]	9817075
C031294	chlorobenzene	[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene	9817075
C031294	chlorobenzene	[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of chlorobenzene	9010585
C031294	chlorobenzene	dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene]	9817075
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP2E1 mRNA	17851650
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP2E1 mRNA	8471063
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP2E1 protein	3113478
D002725	Chloroform	CYP2E1 gene SNP results in increased susceptibility to Chloroform	15289170
D002725	Chloroform	CYP2E1 protein results in increased metabolism of Chloroform	18350910
D002725	Chloroform	CYP2E1 protein results in increased oxidation of Chloroform	1664256
D002726	Chlorogenic Acid	Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein]	25043994
D002737	Chloroprene	Chloroprene results in increased expression of CYP2E1 mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine results in decreased activity of CYP2E1 protein	15135088
D002746	Chlorpromazine	CYP2E1 protein results in decreased susceptibility to Chlorpromazine	26477383
D004390	Chlorpyrifos	Chlorpyrifos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D004390	Chlorpyrifos	Chlorpyrifos results in decreased activity of CYP2E1 protein	22634058
D002753	Chlorzoxazone	[5-bromotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	[5-chlorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	[5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	[5-fluorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	[5-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	[7-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D002753	Chlorzoxazone	chlorfluazuron inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D002753	Chlorzoxazone	[Chlormethiazole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	Chlorpyrifos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D002753	Chlorzoxazone	[Chlorzoxazone results in decreased activity of CYP2E1 protein] which results in decreased degradation of vanoxerine	11502731
D002753	Chlorzoxazone	CYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	15728263
D002753	Chlorzoxazone	CYP2E1 mRNA results in increased metabolism of Chlorzoxazone	29555536
D002753	Chlorzoxazone	[CYP2E1 mRNA results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone	29555536
D002753	Chlorzoxazone	CYP2E1 protein affects the hydroxylation of Chlorzoxazone	7747284
D002753	Chlorzoxazone	CYP2E1 protein affects the metabolism of Chlorzoxazone	12818727; 14586387; 15327588; 15626586;
D002753	Chlorzoxazone	CYP2E1 protein results in increased hydroxylation of Chlorzoxazone	12433797; 12690492; 15255802; 15618748; 15728263; 15802389; 22634058; 26739624; 8558417; 8858968;
D002753	Chlorzoxazone	CYP2E1 protein results in increased metabolism of Chlorzoxazone	12401345; 12464242; 15155557; 15370959; 15576447; 16124035; 17565714; 21915887; 23669205; 28762043; 9817075; 9825833;
D002753	Chlorzoxazone	[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone	23669205
D002753	Chlorzoxazone	CYP2E1 protein results in increased oxidation of Chlorzoxazone	10207612; 21964418;
D002753	Chlorzoxazone	cypermethrin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D002753	Chlorzoxazone	Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]	21915887
D002753	Chlorzoxazone	Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]	23669205
D002753	Chlorzoxazone	Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D002753	Chlorzoxazone	fenvalerate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D002753	Chlorzoxazone	Fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]	21915887
D002753	Chlorzoxazone	[indopan analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	[indopan results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	isoproturon inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D002753	Chlorzoxazone	Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D002753	Chlorzoxazone	[Methoxydimethyltryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	[N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	[N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	perfluorooctane sulfonic acid inhibits the reaction [CYP2E1 protein results in increased oxidation of Chlorzoxazone]	21964418
D002753	Chlorzoxazone	phenthoate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D002753	Chlorzoxazone	profenofos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D002753	Chlorzoxazone	[Tryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D002753	Chlorzoxazone	CYP2E1 protein results in increased hydroxylation of Chlorzoxazone	10463382
D002753	Chlorzoxazone	CYP2E1 protein results in increased metabolism of Chlorzoxazone	25956474; 30503582; 31501917;
D002753	Chlorzoxazone	[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased abundance of 6-hydroxychlorzoxazone	31501917
D002753	Chlorzoxazone	[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone	30503582
D002753	Chlorzoxazone	Resveratrol inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]	25956474
D002753	Chlorzoxazone	CYP2E1 protein results in increased hydroxylation of Chlorzoxazone	21600194
D002753	Chlorzoxazone	Pyrazoles inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	21600194
D002753	Chlorzoxazone	CYP2E1 protein affects the metabolism of Chlorzoxazone	15231049; 15879494;
D002753	Chlorzoxazone	CYP2E1 protein results in increased hydroxylation of Chlorzoxazone	11911841; 15205388; 21600194;
D002753	Chlorzoxazone	CYP2E1 protein results in increased metabolism of Chlorzoxazone	28438436
D002753	Chlorzoxazone	[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone	28438436
D002753	Chlorzoxazone	Imidazoles inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	21600194
D002753	Chlorzoxazone	Isoquinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	21600194
D002753	Chlorzoxazone	Pyridines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	21600194
D002753	Chlorzoxazone	Quinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	21600194
D002784	Cholesterol	Cholesterol results in decreased activity of CYP2E1 protein	18420780
D002793	Cholic Acids	[Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP2E1 mRNA	27344345
D002794	Choline	[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	20118189
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYP2E1 mRNA	22872676
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased activity of CYP2E1 protein	18952117
D002794	Choline	RXRA gene mutant form inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of CYP2E1 protein]	18952117
D002794	Choline	Choline deficiency promotes the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	18798224
D002794	Choline	Choline deficiency promotes the reaction [Phenobarbital results in increased expression of CYP2E1 protein]	18798224
D002794	Choline	geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CYP2E1 protein]	26695085
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CYP2E1 protein	26695085
C031180	chrysene	chrysene results in increased expression of CYP2E1 mRNA	26377693
D002922	Ciguatoxins	Ciguatoxins affects the expression of CYP2E1 mRNA	18353800
D002927	Cimetidine	Cimetidine results in decreased expression of CYP2E1 protein	22733800
D002927	Cimetidine	[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein	22733800
C029010	cinnamic acid	cinnamic acid analog results in decreased activity of CYP2E1 protein	15072549
C019304	ciprofibrate	[Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein	7587954
C019304	ciprofibrate	ciprofibrate results in increased expression of CYP2E1 mRNA	7587954
C019304	ciprofibrate	pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2E1 protein]	7587954
C019304	ciprofibrate	[Thiazoles co-treated with ciprofibrate] results in increased expression of CYP2E1 protein	7587954
D002945	Cisplatin	Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein]	25043994
D002945	Cisplatin	Cisplatin results in increased expression of and results in increased activity of CYP2E1 protein	21616140
D002945	Cisplatin	Cisplatin results in increased expression of CYP2E1 protein	23770416; 25043994;
D002945	Cisplatin	Luteolin inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein]	23770416
D002945	Cisplatin	Cisplatin results in decreased activity of CYP2E1 protein	24882083
D002945	Cisplatin	Cisplatin results in increased expression of CYP2E1 mRNA	22023808
D002945	Cisplatin	CYP2E1 protein results in increased susceptibility to Cisplatin	20809784
D002945	Cisplatin	turmeric extract affects the reaction [Cisplatin results in decreased activity of CYP2E1 protein]	24882083
C007076	citral	[[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral	18824010
C007076	citral	[[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral metabolite	18824010
D002994	Clofibrate	Clofibrate results in increased expression of CYP2E1 protein	19952500
D002994	Clofibrate	Clofibrate affects the expression of CYP2E1 mRNA	16081524
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of CYP2E1 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP2E1 mRNA]	17585979
D002994	Clofibrate	Clofibrate results in increased expression of CYP2E1 mRNA	10476907
D002994	Clofibrate	Clofibrate results in increased expression of CYP2E1 protein	10476907
D003300	Copper	[CYP2E1 protein co-treated with Copper] results in increased activity of Eugenol	15576237
D003300	Copper	Copper results in decreased expression of CYP2E1 mRNA	18522721
D003300	Copper	Copper results in decreased expression of CYP2E1 mRNA	22465980
D003367	Cotinine	Cotinine results in decreased activity of CYP2E1 protein	25221795
C030123	coumarin	coumarin affects the localization of CYP2E1 protein	28803882
D003407	Creosote	Creosote results in increased expression of CYP2E1 mRNA	19389177
C029036	crocin	crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]	25899501
C029036	crocin	crocin results in decreased activity of CYP2E1 protein	25899501
C007164	cumene hydroperoxide	cumene hydroperoxide inhibits the reaction [t-butyl acetylene results in decreased activity of CYP2E1 protein mutant form]	15379534
C007164	cumene hydroperoxide	cumene hydroperoxide promotes the reaction [t-butyl acetylene results in decreased activity of CYP2E1 protein]	15379534
D003474	Curcumin	Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]	24508477
D003474	Curcumin	Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	30423402
D003474	Curcumin	Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	30423402
D003474	Curcumin	Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	30423402
D003474	Curcumin	Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	30423402
D003474	Curcumin	Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]	30423402
D003474	Curcumin	Curcumin affects the expression of CYP2E1 protein	16805852
D003474	Curcumin	Curcumin results in increased expression of CYP2E1 mRNA	18539377
D003486	Cyanides	[CYP2E1 protein results in increased metabolism of methacrylonitrile] which results in increased abundance of Cyanides	15893539
C057862	cyanoginosin LR	allyl sulfide inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 mRNA]	21684301
C057862	cyanoginosin LR	Chlormethiazole inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 mRNA]	21684301
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of CYP2E1 mRNA	21684301
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of CYP2E1 protein	21684301
C057862	cyanoginosin LR	sulforafan inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 mRNA]	21684301
C057862	cyanoginosin LR	sulforafan inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 protein]	21684301
D003511	Cyclohexanols	[Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of CYP2E1 protein	17393424
D003513	Cycloheximide	(4-amidinophenyl)methanesulfonyl fluoride inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	acetonitrile inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	Biotin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	Carbon Tetrachloride promotes the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	Cycloheximide inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136; 9143349;
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	9143349
D003513	Cycloheximide	Cycloheximide promotes the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]	8531136
D003513	Cycloheximide	Cycloheximide results in increased degradation of CYP2E1 protein	9143349
D003513	Cycloheximide	Dimethyl Sulfoxide inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	Edetic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	Egtazic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	Ethanol inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	Fomepizole inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	Glycerol inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	leupeptin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	Tetradecanoylphorbol Acetate inhibits the reaction [Cycloheximide inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
D003513	Cycloheximide	Tosyllysine Chloromethyl Ketone inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D003513	Cycloheximide	Cycloheximide inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]	1968335
D003513	Cycloheximide	Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP2E1 protein]	1968335
D003520	Cyclophosphamide	CYP2E1 results in increased metabolism of Cyclophosphamide	20566340
D016572	Cyclosporine	Cyclosporine results in decreased expression of CYP2E1 mRNA	20106945; 23830897; 27989131;
D016572	Cyclosporine	Cyclosporine results in decreased expression of CYP2E1 mRNA	23830897
C052570	cyfluthrin	cyfluthrin results in increased activity of CYP2E1 protein	23639246
C037304	cyhalothrin	cyhalothrin results in increased expression of CYP2E1 mRNA	29727961
C089595	cylindrospermopsin	cylindrospermopsin results in decreased expression of CYP2E1 mRNA	20936652
C017160	cypermethrin	cypermethrin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
C017160	cypermethrin	cypermethrin results in decreased activity of CYP2E1 protein	22634058
C017160	cypermethrin	cypermethrin results in decreased activity of CYP2E1 protein	18420780
C017160	cypermethrin	[cypermethrin co-treated with propetamphos] results in increased activity of CYP2E1 protein	25926273
C017160	cypermethrin	cypermethrin results in increased activity of CYP2E1 protein	25926273
C017160	cypermethrin	cypermethrin results in increased expression of CYP2E1 mRNA	20815782; 23447098; 26115703;
C017160	cypermethrin	cypermethrin results in increased expression of CYP2E1 protein	23447098; 26115703;
C093628	cyproconazole	cyproconazole results in decreased expression of CYP2E1 mRNA	29995386
C093628	cyproconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of CYP2E1 mRNA	29038839
C004742	daidzein	daidzein results in decreased activity of CYP2E1 protein	18420780
C017180	decamethrin	decamethrin results in increased activity of CYP2E1 protein	16494911
C017180	decamethrin	decamethrin results in increased expression of CYP2E1 mRNA	16494911; 16859670; 25439240;
C017180	decamethrin	decamethrin results in increased expression of CYP2E1 protein	16859670
C017180	decamethrin	Vitamin E inhibits the reaction [decamethrin results in increased expression of CYP2E1 mRNA]	25439240
C031071	decanoic acid	[CYP2E1 protein co-treated with POR protein] results in increased hydroxylation of decanoic acid	2292581
D003671	DEET	CYP2E1 protein results in increased metabolism of DEET	11854147
D003671	DEET	[fipronil co-treated with DEET] results in decreased expression of CYP2E1 mRNA	27091632
D003676	Deferoxamine	Deferoxamine inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in decreased expression of CYP2E1 mRNA	22713311
D003840	Deoxycholic Acid	Deoxycholic Acid results in decreased expression of and results in decreased activity of CYP2E1 protein	10453939
D003840	Deoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of and results in decreased activity of CYP2E1 protein]	10453939
D003891	Desipramine	Desipramine results in decreased activity of CYP2E1 protein	15135088
D003907	Dexamethasone	Dexamethasone results in increased expression of CYP2E1 mRNA	21041162
D003907	Dexamethasone	2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine inhibits the reaction [Dexamethasone results in increased expression of CYP2E1 mRNA]	20501703
D003907	Dexamethasone	Dexamethasone results in decreased expression of CYP2E1 protein	11181506
D003907	Dexamethasone	Dexamethasone results in increased expression of CYP2E1 mRNA	14618091; 20501703; 20607812;
D003907	Dexamethasone	Dexamethasone results in increased expression of CYP2E1 protein	15965953; 20501703;
D003907	Dexamethasone	Quercetin promotes the reaction [Dexamethasone results in increased expression of CYP2E1 mRNA]	20501703
D003907	Dexamethasone	Quercetin promotes the reaction [Dexamethasone results in increased expression of CYP2E1 protein]	20501703
D016264	Dextran Sulfate	Dextran Sulfate results in decreased activity of CYP2E1 protein	28438436
D016264	Dextran Sulfate	[Dextran Sulfate results in decreased activity of CYP2E1 protein] which results in decreased chemical synthesis of 6-hydroxychlorzoxazone	28438436
D003915	Dextromethorphan	Dextromethorphan results in decreased activity of CYP2E1 protein	18420780
C028009	diallyl disulfide	diallyl disulfide inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	19325051
C028009	diallyl disulfide	diallyl disulfide results in decreased activity of CYP2E1 protein	18339364
C028009	diallyl disulfide	diallyl disulfide results in decreased expression of CYP2E1 protein	10774820
C028009	diallyl disulfide	[diallyl disulfide results in decreased expression of CYP2E1 protein] which results in decreased metabolism of and results in decreased susceptibility to Trichloroethylene	10774820
C028009	diallyl disulfide	diallyl disulfide results in decreased expression of CYP2E1 protein	16000231; 24293383;
C068327	diallyl sulfone	diallyl sulfone inhibits the reaction [CYP2E1 protein results in decreased methylation of Dimethylnitrosamine]	11181492
C068327	diallyl sulfone	diallyl sulfone inhibits the reaction [CYP2E1 protein results in increased metabolism of vinylidene chloride]	10215634
C068327	diallyl sulfone	diallyl sulfone inhibits the reaction [CYP2E1 protein affects the oxidation of vinyl carbamate]	17341656
C068327	diallyl sulfone	diallyl sulfone results in decreased activity of CYP2E1 protein	17341656
C068327	diallyl sulfone	[diallyl sulfone results in decreased activity of CYP2E1 protein] which affects the susceptibility to vinyl carbamate	20205516
C068327	diallyl sulfone	diallyl sulfone inhibits the reaction [CYP2E1 protein affects the oxidation of vinyl carbamate]	17296623
C068327	diallyl sulfone	CYP2E1 affects the oxidation of diallyl sulfone	17341656
C042577	diallyl trisulfide	diallyl trisulfide inhibits the reaction [n-hexane results in increased expression of and results in increased activity of CYP2E1 protein]	28115069
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of CYP2E1 protein	28115069
C012279	dibutylnitrosamine	[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to dibutylnitrosamine	11733072
C012279	dibutylnitrosamine	[CYP2E1 protein co-treated with POR protein] results in increased susceptibility to dibutylnitrosamine	11035158
C012279	dibutylnitrosamine	CYP2E1 protein results in increased metabolism of dibutylnitrosamine	8625499
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased activity of CYP2E1 protein	27432241
D004008	Diclofenac	Diclofenac metabolite results in decreased activity of CYP2E1 protein	28960974
D004010	Dicofol	Dicofol results in increased expression of CYP2E1 protein	19595748
D001728	Dicumarol	Dicumarol promotes the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
C007366	diepoxybutane	CYP2E1 gene polymorphism affects the susceptibility to diepoxybutane	15036125
C007366	diepoxybutane	CYP2E1 gene polymorphism results in increased susceptibility to diepoxybutane	17078101
D004041	Dietary Fats	7-hydroxycoumarin inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein]	24661945
D004041	Dietary Fats	CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA]	24211274
D004041	Dietary Fats	CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA]	24211274
D004041	Dietary Fats	CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]	24211274
D004041	Dietary Fats	CYP2E1 protein affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats]	24211274
D004041	Dietary Fats	Dietary Fats affects the expression of CYP2E1 protein	23358370
D004041	Dietary Fats	[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CYP2E1 protein	23438451
D004041	Dietary Fats	[Dietary Fats co-treated with Tobacco Smoke Pollution] results in increased activity of CYP2E1 protein	29688711
D004041	Dietary Fats	Dietary Fats results in decreased expression of CYP2E1 mRNA	18042831; 23954404; 29177473;
D004041	Dietary Fats	Dietary Fats results in increased activity of CYP2E1 protein	24661945; 29688711;
D004041	Dietary Fats	Dietary Fats results in increased expression of CYP2E1 protein	23358370
D004041	Dietary Fats	Hymecromone inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein]	24661945
D004041	Dietary Fats	[Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CYP2E1 protein	19551842
D004041	Dietary Fats	[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased activity of CYP2E1 protein	24815820
D004041	Dietary Fats	Dietary Fats results in increased expression of CYP2E1 protein	17967931
D004041	Dietary Fats	Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CYP2E1 protein]	19551842
D004042	Dietary Fats, Unsaturated	Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of CYP2E1 mRNA]	23626681
D004042	Dietary Fats, Unsaturated	Dietary Fats, Unsaturated results in increased expression of CYP2E1 mRNA	23626681
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of CYP2E1 mRNA	31163220
D004052	Diethylnitrosamine	CYB5A protein promotes the reaction [CYP2E1 protein results in increased activity of Diethylnitrosamine]	15728263
D004052	Diethylnitrosamine	CYP2E1 protein affects the metabolism of and results in increased activity of Diethylnitrosamine	11774366
D004052	Diethylnitrosamine	CYP2E1 protein affects the metabolism of Diethylnitrosamine	2655891
D004052	Diethylnitrosamine	[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Diethylnitrosamine	11733072
D004052	Diethylnitrosamine	[CYP2E1 protein co-treated with POR protein] results in increased susceptibility to Diethylnitrosamine	11035158
D004052	Diethylnitrosamine	CYP2E1 protein results in increased activity of Diethylnitrosamine	15728263
D004052	Diethylnitrosamine	CYP2E1 protein results in increased susceptibility to Diethylnitrosamine	14669323
D004052	Diethylnitrosamine	CYP2E1 protein promotes the reaction [Diethylnitrosamine results in increased expression of BAX mRNA]	18056438
D004052	Diethylnitrosamine	CYP2E1 protein promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 mRNA]	18056438
D004052	Diethylnitrosamine	CYP2E1 protein results in increased susceptibility to Diethylnitrosamine	18056438
D004052	Diethylnitrosamine	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA	16158176
D004052	Diethylnitrosamine	allyl sulfide inhibits the reaction [Diethylnitrosamine results in decreased expression of and results in decreased activity of CYP2E1 protein]	23494807
D004052	Diethylnitrosamine	allyl sulfide inhibits the reaction [Diethylnitrosamine results in decreased expression of CYP2E1 mRNA]	23494807
D004052	Diethylnitrosamine	[Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CYP2E1 protein	19551842
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP2E1 mRNA	14656948
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CYP2E1 protein	17393424
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2E1 protein	16246485
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CYP2E1 mRNA	20360939
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of CYP2E1 protein	17393424
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP2E1 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of and results in decreased activity of CYP2E1 protein	23494807
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of CYP2E1 mRNA	19638242; 20360939; 23494807;
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CYP2E1 mRNA	30423403
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CYP2E1 protein	30423403
D004052	Diethylnitrosamine	neferine inhibits the reaction [Diethylnitrosamine results in increased expression of CYP2E1 mRNA]	30423403
D004052	Diethylnitrosamine	Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CYP2E1 protein]	19551842
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CYP2E1 mRNA	21041162
C035318	diethylthiourea	diethylthiourea results in increased expression of CYP2E1 protein	10190572
C012906	dihydrocapsaicin	dihydrocapsaicin results in increased expression of CYP2E1	22375877
C472036	dihydromyricetin	dihydromyricetin inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	28419832
C039353	dihydroxyethyldithiocarbamate	dihydroxyethyldithiocarbamate inhibits the reaction [CYP2E1 protein results in increased metabolism of chlorobenzene]	9817075
C039353	dihydroxyethyldithiocarbamate	dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of 2-dichlorobenzene]	9817075
C039353	dihydroxyethyldithiocarbamate	dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene]	9817075
D004114	Dimethadione	CYP2E1 protein results in decreased methylation of Dimethadione	8865369
C521105	dimethoxycurcumin	dimethoxycurcumin results in increased expression of CYP2E1 mRNA	31513842
D004126	Dimethylformamide	CYP2E1 polymorphism results in increased abundance of Dimethylformamide metabolite	31501917
D004126	Dimethylformamide	CYP2E1 protein polymorphism affects the metabolism of Dimethylformamide	11305777
D004126	Dimethylformamide	CYP2E1 protein results in increased metabolism of Dimethylformamide	9817075
D004126	Dimethylformamide	CYP2E1 protein results in increased oxidation of Dimethylformamide	10207612
D004126	Dimethylformamide	Dimethylformamide results in increased expression of CYP2E1 protein	29984871
D004126	Dimethylformamide	CYP2E1 protein affects the reaction [Dimethylformamide results in increased activity of GPT protein]	31501917
D004126	Dimethylformamide	CYP2E1 protein affects the reaction [Dimethylformamide results in increased expression of HSP90B1 protein]	31501917
D004126	Dimethylformamide	CYP2E1 protein results in increased susceptibility to Dimethylformamide	31501917
D004126	Dimethylformamide	Dimethylformamide results in increased expression of CYP2E1 protein	10547960
D004126	Dimethylformamide	CYP2E1 protein affects the metabolism of Dimethylformamide	15772367
C073972	dimethyl mercury	[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP2E1 protein]	21424224
C073972	dimethyl mercury	dimethyl mercury results in decreased expression of CYP2E1 protein	21424224
D004128	Dimethylnitrosamine	CYP2E1 protein affects the metabolism of and results in increased activity of Dimethylnitrosamine	11600130
D004128	Dimethylnitrosamine	CYP2E1 protein affects the metabolism of Dimethylnitrosamine	16235733; 2655891;
D004128	Dimethylnitrosamine	[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Dimethylnitrosamine	11733072
D004128	Dimethylnitrosamine	CYP2E1 protein results in decreased methylation of Dimethylnitrosamine	11181492
D004128	Dimethylnitrosamine	CYP2E1 protein results in increased metabolism of and results in increased activity of Dimethylnitrosamine	11960914
D004128	Dimethylnitrosamine	CYP2E1 protein results in increased metabolism of Dimethylnitrosamine	12464242; 15242818;
D004128	Dimethylnitrosamine	diallyl sulfone inhibits the reaction [CYP2E1 protein results in decreased methylation of Dimethylnitrosamine]	11181492
D004128	Dimethylnitrosamine	Dimethylnitrosamine inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
D004128	Dimethylnitrosamine	Dimethylnitrosamine inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]	8531136
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased activity of CYP2E1 protein	24561005
D004128	Dimethylnitrosamine	Ethanol affects the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]	16235733
D004128	Dimethylnitrosamine	Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of Dimethylnitrosamine]	8074729
D004128	Dimethylnitrosamine	Lipopolysaccharides affects the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]	16235733
D004128	Dimethylnitrosamine	[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to Dimethylnitrosamine	27913846
D004128	Dimethylnitrosamine	[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to Dimethylnitrosamine] which results in increased mutagenesis of HPRT1 gene	27913846
D004128	Dimethylnitrosamine	[vinyl carbamate co-treated with NADP] inhibits the reaction [CYP2E1 protein results in decreased methylation of Dimethylnitrosamine]	11181492
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of CYP2E1 mRNA	11356909
D004128	Dimethylnitrosamine	Alloxan affects the reaction [CYP2E1 protein results in decreased methylation of Dimethylnitrosamine]	17034923
D004128	Dimethylnitrosamine	CYP2E1 protein affects the metabolism of Dimethylnitrosamine	15815077
D004128	Dimethylnitrosamine	[CYP2E1 protein co-treated with POR protein] results in decreased methylation of Dimethylnitrosamine	2292581
D004128	Dimethylnitrosamine	CYP2E1 protein results in decreased methylation of Dimethylnitrosamine	17034923
D004128	Dimethylnitrosamine	Dimethylnitrosamine binds to CYP2E1 protein	15815077
D004128	Dimethylnitrosamine	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]	8117321
D004128	Dimethylnitrosamine	CYP2E1 protein results in decreased methylation of Dimethylnitrosamine	3113478; 8194125;
D004128	Dimethylnitrosamine	CYP2E1 protein results in increased metabolism of Dimethylnitrosamine	15763544
D004128	Dimethylnitrosamine	S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]	15763544
D004128	Dimethylnitrosamine	CYP2E1 protein results in increased metabolism of and results in increased activity of Dimethylnitrosamine	16142352
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide affects the expression of CYP2E1 mRNA	12843640
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]]	12147272
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of CYP2E1 mRNA	30262279
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of CYP2E1 protein	8074729
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased activity of CYP2E1 protein	17177172
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide binds to and results in increased expression of CYP2E1 protein	3337723
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]	19858067
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein results in increased metabolism of methylformamide]	1538706
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of CYP2E1 protein	3113478
C106479	di-n-propylphthalate	di-n-propylphthalate results in decreased activity of CYP2E1 protein	27432241
C019357	dioscin	dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]	22939915
C019357	dioscin	dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	24146112
C039602	diosmetin	diosmetin results in decreased activity of CYP2E1 protein	28867436
D004145	Diosmin	Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein]	23665045
D004148	Dioxolanes	Dioxolanes results in decreased activity of CYP2E1 protein	16331285
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]	26880746
C007517	diphenyleneiodonium	diphenyleneiodonium results in decreased activity of CYP2E1 protein	26880746
C087894	dipropyl sulfide	dipropyl sulfide results in decreased activity of CYP2E1 protein	18339364
D004221	Disulfiram	Disulfiram inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]	21915887
D004221	Disulfiram	Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]	21915887
D004221	Disulfiram	Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]	23669205
D004221	Disulfiram	Disulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane]	10805064
D004221	Disulfiram	Disulfiram results in decreased activity of CYP2E1 protein	1664256; 21915887; 8637342;
D004221	Disulfiram	[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene	20470765
D004221	Disulfiram	Disulfiram binds to and results in decreased activity of CYP2E1 protein	18754103
D004221	Disulfiram	Disulfiram results in decreased activity of CYP2E1 protein	9393675
D004221	Disulfiram	Disulfiram results in decreased expression of CYP2E1 mRNA	9393675
D004221	Disulfiram	Disulfiram results in decreased expression of CYP2E1 protein	9393675
D004221	Disulfiram	Disulfiram inhibits the reaction [4-xylene results in increased activity of CYP2E1 protein]	12781212
D004221	Disulfiram	Disulfiram inhibits the reaction [Toluene results in increased activity of CYP2E1 protein]	12781212
D004221	Disulfiram	Disulfiram results in decreased activity of CYP2E1	12803597
D004221	Disulfiram	Disulfiram results in decreased activity of CYP2E1 protein	19616568; 20470765;
D004050	Ditiocarb	Ditiocarb inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene]	8592870
D004050	Ditiocarb	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased glutathionylation of Lamotrigine]	19961160
D004050	Ditiocarb	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 2-xylene]	8558417
D004050	Ditiocarb	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 3-xylene]	8558417
D004050	Ditiocarb	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-xylene]	8558417
D004050	Ditiocarb	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Theobromine]	10215755
D004050	Ditiocarb	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Toluene]	8558417
D004050	Ditiocarb	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]	12086689
D004050	Ditiocarb	Ditiocarb results in decreased activity of CYP2E1 protein	15306208; 1664256; 8819299;
D004050	Ditiocarb	[Ditiocarb co-treated with CYP2E1 gene mutant form] results in decreased metabolism of Styrene	12746132
D004050	Ditiocarb	[Ditiocarb results in decreased activity of CYP2E1 protein] which results in decreased oxidation of Benzene	8560479
D004050	Ditiocarb	Ditiocarb inhibits the reaction [[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene]	9010585
D004050	Ditiocarb	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	9618253
D004050	Ditiocarb	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of methylformamide]	1538706
D004050	Ditiocarb	Ditiocarb inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]	9618253
D004050	Ditiocarb	Ditiocarb results in decreased activity of CYP2E1 protein	1356728
D004050	Ditiocarb	Ditiocarb results in decreased activity of CYP2E1	10910959
D004050	Ditiocarb	Ditiocarb results in decreased activity of CYP2E1 protein	12086689; 19616568; 19961160; 8560479; 9103523;
D004281	Docosahexaenoic Acids	Chlormethiazole inhibits the reaction [Docosahexaenoic Acids results in increased expression of CYP2E1 protein]	16963249
D004281	Docosahexaenoic Acids	CYP2E1 protein results in increased susceptibility to Docosahexaenoic Acids	16963249
D004281	Docosahexaenoic Acids	[CYP2E1 protein results in increased susceptibility to Docosahexaenoic Acids] which affects the localization of FASLG protein	16963249
D004281	Docosahexaenoic Acids	[CYP2E1 protein results in increased susceptibility to Docosahexaenoic Acids] which results in increased activity of CASP3 protein	16963249
D004281	Docosahexaenoic Acids	[CYP2E1 protein results in increased susceptibility to Docosahexaenoic Acids] which results in increased activity of CASP7 protein	16963249
D004281	Docosahexaenoic Acids	[CYP2E1 protein results in increased susceptibility to Docosahexaenoic Acids] which results in increased expression of BAD protein	16963249
D004281	Docosahexaenoic Acids	[CYP2E1 protein results in increased susceptibility to Docosahexaenoic Acids] which results in increased phosphorylation of MAP2K4 protein	16963249
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids results in decreased activity of CYP2E1 protein	16978661
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids results in increased expression of CYP2E1 protein	16963249
D004281	Docosahexaenoic Acids	Quercetin inhibits the reaction [[CYP2E1 protein results in increased susceptibility to Docosahexaenoic Acids] which results in increased phosphorylation of MAP2K4 protein]	16963249
D004298	Dopamine	Dopamine results in decreased activity of CYP2E1 protein	18420780
D004317	Doxorubicin	Doxorubicin results in increased expression of CYP2E1 mRNA	26873546
D000077764	Dronedarone	CYP2E1 protein results in increased metabolism of Dronedarone	29616291
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	24582681
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal results in decreased expression of CYP2E1 mRNA	15706880; 26590097;
C042986	ebselen	ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	11903743
D004492	Edetic Acid	Edetic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D004533	Egtazic Acid	Egtazic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid results in decreased activity of CYP2E1 protein	16978661
C034192	ellipticine	CYP2E1 protein results in increased metabolism of ellipticine	22917556
C108024	emamectin benzoate	emamectin benzoate results in increased expression of CYP2E1 mRNA	29268245
C108024	emamectin benzoate	Plant Oils inhibits the reaction [emamectin benzoate results in increased expression of CYP2E1 mRNA]	29268245
C070609	EMD 53998	EMD 53998 analog results in increased expression of CYP2E1 mRNA	24977338
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP2E1 mRNA	26159488
D004726	Endosulfan	Endosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]	28673560
D004726	Endosulfan	Endosulfan results in decreased expression of CYP2E1 mRNA	26159488; 28673560;
D004726	Endosulfan	Endosulfan results in decreased expression of CYP2E1 protein	28673560
D004726	Endosulfan	Tetrachlorodibenzodioxin promotes the reaction [Endosulfan results in decreased expression of CYP2E1 mRNA]	28673560
D004726	Endosulfan	Endosulfan analog results in increased expression of CYP2E1 mRNA	29702342
D004726	Endosulfan	Endosulfan results in increased expression of CYP2E1 mRNA	29702342
D004726	Endosulfan	Endosulfan results in increased expression of CYP2E1 mRNA	29391264
C544689	endosulfan sulfate	endosulfan sulfate results in increased expression of CYP2E1 mRNA	29702342
D000077560	Enfuvirtide	Enfuvirtide affects the activity of CYP2E1 protein	15656696
D004785	Environmental Pollutants	CYP2E1 polymorphism affects the susceptibility to Environmental Pollutants	19686770
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]	24508477
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of and results in increased activity of CYP2E1 protein	14600287
C045651	epigallocatechin gallate	epigallocatechin gallate binds to CYP2E1 protein	23010222
C109476	epoxiconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of CYP2E1 mRNA	29038839
C091891	epsilon-viniferin	epsilon-viniferin results in decreased activity of CYP2E1 protein	12818727
D004958	Estradiol	Estradiol results in decreased expression of CYP2E1 mRNA	20106945
D004958	Estradiol	Estradiol results in increased activity of CYP2E1 protein	22837389
D004958	Estradiol	Estradiol results in decreased expression of CYP2E1 mRNA	19484750
D004958	Estradiol	[Estradiol co-treated with Plant Preparations] results in decreased expression of CYP2E1 mRNA	26945725
C007633	estragole	CYP2E1 protein results in increased hydroxylation of estragole	19920071
D004967	Estrogens	Estrogens results in decreased expression of CYP2E1 protein	2785912
D004977	Ethambutol	Ethambutol results in decreased activity of CYP2E1 protein	24910189
D004977	Ethambutol	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein	27919644
D004977	Ethambutol	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA	27919644
D004977	Ethambutol	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D004977	Ethambutol	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D004977	Ethambutol	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D004977	Ethambutol	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D000431	Ethanol	[Ascorbic Acid co-treated with Ethanol] results in decreased expression of CYP2E1 mRNA	22149461
D000431	Ethanol	Ethanol results in increased activity of CYP2E1 protein	12451447
D000431	Ethanol	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	29362861
D000431	Ethanol	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	28385499
D000431	Ethanol	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	28385499
D000431	Ethanol	allyl sulfide inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	22138249
D000431	Ethanol	[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein	17034788
D000431	Ethanol	[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein	17034788
D000431	Ethanol	[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein	17034788
D000431	Ethanol	Betaine promotes the reaction [Ethanol results in increased expression of CYP2E1]	21352821
D000431	Ethanol	Catechin inhibits the reaction [Ethanol results in increased expression of CYP2E1]	21352821
D000431	Ethanol	CYP2E1 gene polymorphism affects the susceptibility to Ethanol	20171022
D000431	Ethanol	CYP2E1 protein affects the reaction [Ethanol results in decreased expression of DBN1 mRNA]	28385499
D000431	Ethanol	CYP2E1 protein affects the reaction [Ethanol results in decreased expression of PPARA mRNA]	28385499
D000431	Ethanol	CYP2E1 protein affects the reaction [Ethanol results in decreased expression of SYP mRNA]	28385499
D000431	Ethanol	CYP2E1 protein promotes the reaction [Ethanol results in increased expression of GCLC mRNA]	19133322
D000431	Ethanol	CYP2E1 protein results in increased metabolism of Ethanol	10573527; 10826103; 12464242; 18845238; 22530035;
D000431	Ethanol	[CYP2E1 protein results in increased metabolism of Ethanol] promotes the reaction [Ethanol results in increased expression of CYP2A6]	22530035
D000431	Ethanol	[CYP2E1 protein results in increased metabolism of Ethanol] which results in decreased abundance of Glutathione	10573527
D000431	Ethanol	[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Acetaldehyde	18845238
D000431	Ethanol	[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Nitric Oxide	18845238
D000431	Ethanol	[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species	18845238
D000431	Ethanol	CYP2E1 protein results in increased susceptibility to Ethanol	8798623
D000431	Ethanol	diallyl disulfide inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	19325051
D000431	Ethanol	Ethanol affects the activity of CYP2E1 protein	22530035
D000431	Ethanol	[Ethanol affects the activity of CYP2E1 protein] which affects the localization of NFE2L2 protein	22530035
D000431	Ethanol	[[Ethanol affects the activity of CYP2E1 protein] which affects the localization of NFE2L2 protein] which results in increased expression of CYP2A6	22530035
D000431	Ethanol	Ethanol affects the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]	16235733
D000431	Ethanol	Ethanol affects the reaction [CYP2E1 protein results in increased susceptibility to Acetaminophen]	11212141
D000431	Ethanol	[Ethanol co-treated with CYP2E1 protein] results in increased abundance of Reactive Oxygen Species	22222162
D000431	Ethanol	[Ethanol co-treated with CYP2E1 protein] results in increased phosphorylation of EGFR protein	22222162
D000431	Ethanol	Ethanol inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
D000431	Ethanol	Ethanol inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D000431	Ethanol	Ethanol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]	29362861
D000431	Ethanol	Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8074729; 8531136;
D000431	Ethanol	Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of aniline]	8074729
D000431	Ethanol	Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of Dimethylnitrosamine]	8074729
D000431	Ethanol	Ethanol results in increased activity of CYP2E1 protein	11212141; 8074729;
D000431	Ethanol	Ethanol results in increased expression of and results in increased activity of CYP2E1 protein	15802389; 18845238; 19325051; 22552773;
D000431	Ethanol	Ethanol results in increased expression of CYP2E1	21352821
D000431	Ethanol	Ethanol results in increased expression of CYP2E1 mRNA	23300006; 27794450; 28062356; 28385499; 29362861; 30567741;
D000431	Ethanol	Ethanol results in increased expression of CYP2E1 protein	17590308; 22138249; 28385499; 30373287; 30567741; 3782137; 8074729;
D000431	Ethanol	Fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species]	18845238
D000431	Ethanol	Hemin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	19325051
D000431	Ethanol	PPP2CA protein affects the reaction [Ethanol results in increased expression of CYP2E1 protein]	30567741
D000431	Ethanol	PPP2R5A protein affects the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	30567741
D000431	Ethanol	PPP2R5A protein affects the reaction [Ethanol results in increased expression of CYP2E1 protein]	30567741
D000431	Ethanol	Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	19325051
D000431	Ethanol	Tetradecanoylphorbol Acetate promotes the reaction [CYP2E1 protein results in increased susceptibility to Ethanol]	8798623
D000431	Ethanol	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	19325051
D000431	Ethanol	U 0126 inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	28385499
D000431	Ethanol	U 0126 inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	28385499
D000431	Ethanol	zinc protoporphyrin inhibits the reaction [Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]]	19325051
D000431	Ethanol	zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]]	19325051
D000431	Ethanol	[AQP4 protein affects the susceptibility to Ethanol] which affects the expression of CYP2E1 mRNA	20615459
D000431	Ethanol	Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	25455889
D000431	Ethanol	[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	20118189
D000431	Ethanol	[Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of CYP2E1 mRNA	30517762
D000431	Ethanol	Chlormethiazole inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	22552773
D000431	Ethanol	Chlormethiazole inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	24892905
D000431	Ethanol	CYP2E1 protein affects the reaction [Ethanol results in increased expression of and results in increased activity of CYP2A5 protein]	22552773
D000431	Ethanol	CYP2E1 protein affects the reaction [Ethanol results in increased expression of CYP2A5]	28131861
D000431	Ethanol	CYP2E1 protein results in increased oxidation of Ethanol	22552773
D000431	Ethanol	CYP2E1 protein results in increased susceptibility to Ethanol	28131861
D000431	Ethanol	dihydromyricetin inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	28419832
D000431	Ethanol	dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	24146112
D000431	Ethanol	Ethanol promotes the reaction [ethylene dichloride results in increased expression of CYP2E1 mRNA]	30664321
D000431	Ethanol	Ethanol promotes the reaction [Fructose results in increased expression of CYP2E1 protein]	26858005
D000431	Ethanol	Ethanol results in decreased expression of CYP2E1 mRNA	28119953
D000431	Ethanol	Ethanol results in increased activity of CYP2E1 protein	10667633; 15920153;
D000431	Ethanol	Ethanol results in increased expression of and results in increased activity of CYP2E1 protein	22552773; 24146112; 24892905; 28131861; 28797650;
D000431	Ethanol	Ethanol results in increased expression of CYP2E1	16317704
D000431	Ethanol	Ethanol results in increased expression of CYP2E1 mRNA	30664321
D000431	Ethanol	Ethanol results in increased expression of CYP2E1 protein	11515535; 15920153; 19063909; 19951287; 20118189; 22138249; 24946281; 25455889; 25460735; 26769846; 26858005; 28119953; 28419832;
D000431	Ethanol	[ethylene dichloride co-treated with Ethanol] results in increased expression of CYP2E1 protein	30664321
D000431	Ethanol	ethylene dichloride promotes the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	30664321
D000431	Ethanol	Plant Extracts inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	28797650
D000431	Ethanol	Silymarin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	28797650
D000431	Ethanol	SOD1 protein affects the reaction [Ethanol results in increased expression of CYP2E1 protein]	19951287
D000431	Ethanol	[Urethane co-treated with Ethanol] results in increased activity of CYP2E1 protein	15582191
D000431	Ethanol	[Zinc deficiency co-treated with Ethanol] results in increased expression of CYP2E1 protein	24155903
D000431	Ethanol	Zinc Sulfate inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	15920153
D000431	Ethanol	Zinc Sulfate inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	15920153
D000431	Ethanol	allyl sulfide inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	20116195
D000431	Ethanol	Carnitine promotes the reaction [Ethanol results in increased expression of CYP2E1 protein]	8130774
D000431	Ethanol	CYP2E1 protein results in increased metabolism of Ethanol	11147839; 15763544; 7562599;
D000431	Ethanol	[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde	7562599
D000431	Ethanol	CYP2E1 protein results in increased susceptibility to Ethanol	21130154
D000431	Ethanol	Ethanol affects the activity of CYP2E1 protein	17533807
D000431	Ethanol	Ethanol binds to and results in increased expression of CYP2E1 protein	3337723
D000431	Ethanol	[Ethanol co-treated with nitrosobenzylmethylamine] results in increased expression of CYP2E1 protein	16704527
D000431	Ethanol	Ethanol inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000431	Ethanol	Ethanol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CYP2E1 mRNA]	26854922
D000431	Ethanol	Ethanol promotes the reaction [CYP2E1 protein results in increased hydroxylation of aniline]	23274713
D000431	Ethanol	Ethanol promotes the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]	7601153
D000431	Ethanol	Ethanol promotes the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]	7601153
D000431	Ethanol	Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of Toluene]	1994898
D000431	Ethanol	Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]	26747958
D000431	Ethanol	Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]	26747958
D000431	Ethanol	Ethanol results in decreased activity of CYP2E1 protein	17299812
D000431	Ethanol	Ethanol results in increased activity of and results in increased expression of CYP2E1 protein	23274713
D000431	Ethanol	Ethanol results in increased activity of CYP2E1 protein	15998439; 20116195; 21704112; 22525864; 28442378;
D000431	Ethanol	[Ethanol results in increased activity of CYP2E1 protein] which results in increased metabolism of vinyl fluoride	9073601
D000431	Ethanol	Ethanol results in increased expression of and results in increased activity of CYP2E1 protein	15946133; 21999510; 22960445; 24146112; 25111957;
D000431	Ethanol	Ethanol results in increased expression of CYP2E1 mRNA	21999510; 22960445; 23273579; 23819932; 26747958; 26854922; 28385499; 7562599; 8130774;
D000431	Ethanol	Ethanol results in increased expression of CYP2E1 protein	19609968; 23819932; 26747958; 27989594; 3113478; 3416296; 3782137; 7562599; 7587954; 7601153; 8130774; 9884160;
D000431	Ethanol	Genistein inhibits the reaction [Ethanol promotes the reaction [CYP2E1 protein results in increased hydroxylation of aniline]]	23274713
D000431	Ethanol	Genistein inhibits the reaction [Ethanol results in increased activity of and results in increased expression of CYP2E1 protein]	23274713
D000431	Ethanol	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA]	26747958
D000431	Ethanol	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein]	26747958
D000431	Ethanol	Oleanolic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	25111957
D000431	Ethanol	[Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	26854922
D000431	Ethanol	[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 mRNA	26747958
D000431	Ethanol	[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 protein	26747958
D000431	Ethanol	[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA	26747958
D000431	Ethanol	[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein	26747958
D000431	Ethanol	phenethyl isothiocyanate inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde]	7562599
D000431	Ethanol	phenethyl isothiocyanate inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	7562599
D000431	Ethanol	phenethyl isothiocyanate inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	7562599
D000431	Ethanol	Plant Extracts inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	22525864
D000431	Ethanol	S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol]	15763544
D000431	Ethanol	salvianolic acid B inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	27989594
D000431	Ethanol	zingerone inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	28442378
D000431	Ethanol	CYP2E1 protein results in increased metabolism of Ethanol	16470306; 16737972; 22960445;
D000431	Ethanol	Ethanol promotes the reaction [CYP2E1 protein results in increased metabolism of Tretinoin]	16054987
D000431	Ethanol	Ethanol promotes the reaction [CYP2E1 protein results in increased metabolism of Vitamin A]	16054987
D000431	Ethanol	Ethanol results in decreased activity of CYP2E1 protein	7710944
D000431	Ethanol	Ethanol results in increased expression of CYP2E1 protein	16054987
D005013	Ethosuximide	CYP2E1 protein affects the metabolism of Ethosuximide	1438522
C004912	ethylbenzene	ethylbenzene results in increased expression of and results in increased activity of CYP2E1 protein	11884239
C004912	ethylbenzene	ethylbenzene results in increased expression of CYP2E1 mRNA	11884239
C004912	ethylbenzene	ethylbenzene results in increased expression of CYP2E1 protein	1417939; 8517779;
C004912	ethylbenzene	GH1 protein inhibits the reaction [ethylbenzene results in increased expression of CYP2E1 protein]	11884239
C036216	ethylene	CYP2E1 protein results in increased metabolism of ethylene	21785163
C036216	ethylene	[CYP2E1 protein results in increased metabolism of ethylene] which results in increased abundance of Ethylene Oxide	21785163
C036216	ethylene	ethylene results in decreased activity of CYP2E1 protein	15141094
C025475	ethylene bromohydrin	CYP2E1 protein results in increased metabolism of ethylene bromohydrin	8861782
D005023	Ethylene Chlorohydrin	[CYP2E1 protein results in increased metabolism of Vinyl Chloride] which results in increased abundance of Ethylene Chlorohydrin	26962056
D015946	Ethylene Dibromide	CYP2E1 protein results in increased metabolism of Ethylene Dibromide	10841534; 18350910;
D015946	Ethylene Dibromide	CYP2E1 protein results in increased oxidation of Ethylene Dibromide	1664256
C024565	ethylene dichloride	CYP2E1 protein results in increased oxidation of ethylene dichloride	1664256
C024565	ethylene dichloride	allyl sulfide inhibits the reaction [ethylene dichloride results in increased expression of CYP2E1 protein]	27301210
C024565	ethylene dichloride	Ethanol promotes the reaction [ethylene dichloride results in increased expression of CYP2E1 mRNA]	30664321
C024565	ethylene dichloride	[ethylene dichloride co-treated with Ethanol] results in increased expression of CYP2E1 protein	30664321
C024565	ethylene dichloride	ethylene dichloride promotes the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	30664321
C024565	ethylene dichloride	ethylene dichloride results in increased expression of CYP2E1 mRNA	28189721; 30664321;
C024565	ethylene dichloride	ethylene dichloride results in increased expression of CYP2E1 protein	27301210; 28189721;
D005027	Ethylene Oxide	[CYP2E1 protein results in increased metabolism of ethylene] which results in increased abundance of Ethylene Oxide	21785163
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of CYP2E1 mRNA	23649840
C012313	ethyl-p-hydroxybenzoate	ethyl-p-hydroxybenzoate results in decreased activity of CYP2E1 protein	27432241
C098546	ethyl tert-butyl ether	ethyl tert-butyl ether results in increased expression of CYP2E1 mRNA	24090815
C098546	ethyl tert-butyl ether	ethyl tert-butyl ether results in increased expression of CYP2E1 protein	24090815
D005054	Eugenol	[CYP2E1 protein co-treated with Copper] results in increased activity of Eugenol	15576237
D005054	Eugenol	Eugenol inhibits the reaction [Thioacetamide results in increased expression of CYP2E1 protein]	20036707
D005204	Farnesol	[Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2E1 mRNA	30611723
D005204	Farnesol	Farnesol analog inhibits the reaction [Oleic Acid results in increased expression of CYP2E1 mRNA]	30611723
D005204	Farnesol	Farnesol analog results in decreased expression of CYP2E1 mRNA	30611723
D005204	Farnesol	Farnesol results in decreased expression of CYP2E1 mRNA	30611723
D005204	Farnesol	Farnesol results in increased activity of CYP2E1 protein	15840382
D005227	Fatty Acids	[Acetaminophen results in increased activity of CYP2E1 protein] inhibits the reaction [PPARA protein results in increased oxidation of Fatty Acids]	19256530
D000078328	Felbamate	Felbamate results in decreased expression of CYP2E1 mRNA	17381134
C033789	fenarimol	[fenarimol co-treated with acephate] affects the expression of CYP2E1 protein	17686559
C033789	fenarimol	[fenarimol co-treated with vinclozolin] affects the expression of CYP2E1 protein	17686559
C033789	fenarimol	[fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2E1 protein	17686559
D005273	Fenbendazole	Fenbendazole affects the expression of CYP2E1 mRNA	26366864
D005278	Fenitrothion	Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D005278	Fenitrothion	Fenitrothion results in decreased activity of CYP2E1 protein	22634058
D011345	Fenofibrate	Fenofibrate results in increased expression of CYP2E1 mRNA	19118567
C017690	fenvalerate	fenvalerate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
C017690	fenvalerate	fenvalerate results in decreased activity of CYP2E1 protein	22634058
C045858	ferric-adenosine triphosphate complex	ferric-adenosine triphosphate complex inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136
C045858	ferric-adenosine triphosphate complex	ferric-adenosine triphosphate complex results in increased degradation of CYP2E1 protein	8531136
C025314	ferric citrate	Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP2E1 mRNA]	24025710
C025314	ferric citrate	ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP2E1 mRNA]	24025710
C025314	ferric citrate	ferric citrate results in increased expression of CYP2E1 mRNA	24025710
C020326	ferric nitrilotriacetate	allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]	12086689
C020326	ferric nitrilotriacetate	[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein	17034788
C020326	ferric nitrilotriacetate	[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein	17034788
C020326	ferric nitrilotriacetate	[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein	17034788
C020326	ferric nitrilotriacetate	CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]	12086689; 21352821;
C020326	ferric nitrilotriacetate	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]	12086689
C020326	ferric nitrilotriacetate	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]	12086689
D005363	Ficusin	Ficusin results in decreased expression of CYP2E1 protein	22173200
C082360	fipronil	[fipronil co-treated with DEET] results in decreased expression of CYP2E1 mRNA	27091632
C082360	fipronil	fipronil results in decreased expression of CYP2E1 mRNA	27091632
C082360	fipronil	fipronil results in increased expression of CYP2E1 mRNA	23962444
D005411	Flame Retardants	Flame Retardants results in increased expression of CYP2E1 mRNA	26808241
D005419	Flavonoids	Flavonoids inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	23279844
C014558	flunixin meglumine	flunixin meglumine affects the expression of CYP2E1 mRNA	26366864
C007738	fluoranthene	fluoranthene results in increased expression of CYP2E1 mRNA	16269432
D005476	Fluphenazine	Fluphenazine results in decreased activity of CYP2E1 protein	15135088
D005492	Folic Acid	[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	20118189
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYP2E1 mRNA	22872676
D000077604	Fomepizole	Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene]	8592870
D000077604	Fomepizole	Fomepizole inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
D000077604	Fomepizole	Fomepizole inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]	8531136
D000077604	Fomepizole	Fomepizole inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D000077604	Fomepizole	Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of 2,6-xylidine metabolite]	11409937
D000077604	Fomepizole	Fomepizole inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]	21915887
D000077604	Fomepizole	Fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]	21915887
D000077604	Fomepizole	Fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species]	18845238
D000077604	Fomepizole	Fomepizole results in decreased activity of CYP2E1 protein	21336516; 21915887; 24561005;
D000077604	Fomepizole	[Fomepizole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of vinyl fluoride	9073601
D000077604	Fomepizole	Fomepizole results in increased expression of CYP2E1 protein	8074729
D000077604	Fomepizole	[Fomepizole results in decreased activity of CYP2E1 protein] which results in decreased uptake of vinyl fluoride	9073601
D000077604	Fomepizole	Fomepizole promotes the reaction [CYP2E1 protein results in increased metabolism of methylformamide]	1538706
D000077604	Fomepizole	Fomepizole results in increased activity of CYP2E1 protein	3782137
D000077604	Fomepizole	Fomepizole results in increased expression of CYP2E1 protein	3113478; 3782137;
D000077604	Fomepizole	Fomepizole results in decreased activity of CYP2E1 protein	10828259; 16737972; 9103523;
D005503	Food Additives	Food Additives results in increased expression of CYP2E1 mRNA	18803703
D005579	Fossil Fuels	Fossil Fuels results in increased expression of CYP2E1 protein	14961354
D005632	Fructose	Ethanol promotes the reaction [Fructose results in increased expression of CYP2E1 protein]	26858005
D005632	Fructose	Fructose results in decreased expression of CYP2E1 protein	28257781
D005632	Fructose	Fructose results in increased expression of CYP2E1 protein	26858005
C069837	fullerene C60	fullerene C60 results in increased expression of CYP2E1 mRNA	19167457
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP2E1 mRNA]	29362861
C056933	fumonisin B1	fumonisin B1 results in decreased expression of CYP2E1 mRNA	16221962
C050131	furafylline	furafylline results in decreased activity of CYP2E1 protein	15879494
C039281	furan	1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]	21842885
C039281	furan	[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde	21842885
C039281	furan	[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde	21842885
C039281	furan	furan results in decreased expression of CYP2E1 mRNA	15120968
C039281	furan	furan results in decreased expression of CYP2E1 protein	20124500
C039281	furan	CYP2E1 protein results in increased metabolism of furan	22240984; 24183702;
C039281	furan	[CYP2E1 protein results in increased metabolism of furan] which results in increased chemical synthesis of malealdehyde	22240984; 24183702;
D000077206	Gabapentin	Gabapentin results in decreased expression of CYP2E1 mRNA	17381134
C038958	gadolinium chloride	gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 mRNA]	18202523
C038958	gadolinium chloride	gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 protein]	18202523
D005688	Galactosamine	Galactosamine results in decreased expression of CYP2E1 protein	16208626
D005742	Gasoline	Gasoline results in increased expression of CYP2E1 protein	14961354
D019833	Genistein	Genistein inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]	23333575
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in increased expression of CYP2E1 mRNA	21782745
D019833	Genistein	Genistein inhibits the reaction [Ethanol promotes the reaction [CYP2E1 protein results in increased hydroxylation of aniline]]	23274713
D019833	Genistein	Genistein inhibits the reaction [Ethanol results in increased activity of and results in increased expression of CYP2E1 protein]	23274713
D005839	Gentamicins	[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2E1 mRNA	30545405
C007836	geraniol	[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol	18824010
C007836	geraniol	[[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral	18824010
C007836	geraniol	[[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of citral metabolite	18824010
C007836	geraniol	[[CYP1A1 protein co-treated with CYP1B1 protein co-treated with CYP2B6 protein co-treated with CYP2E1 protein co-treated with CYP3A5 protein] results in increased metabolism of geraniol] which results in increased chemical synthesis of geraniol metabolite	18824010
C007836	geraniol	geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CYP2E1 protein]	26695085
C063170	Ginkgo biloba extract	Ginkgo biloba extract results in decreased activity of CYP2E1 protein	15147983
C063170	Ginkgo biloba extract	Ginkgo biloba extract results in increased expression of and results in increased activity of CYP2E1 protein	18421621
C111520	ginsan	ginsan promotes the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]	19913046
C111520	ginsan	ginsan results in decreased expression of CYP2E1 protein	19913046
C035054	ginsenoside Rg1	ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	29964319
D005897	Glafenine	Glafenine results in decreased expression of CYP2E1 mRNA	24136188
D005978	Glutathione	[CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac	24246759
D005978	Glutathione	[CYP2E1 protein results in increased metabolism of Ethanol] which results in decreased abundance of Glutathione	10573527
D005978	Glutathione	Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]	16872732
D005978	Glutathione	Glutathione inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein]	28803762
D005978	Glutathione	1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]	21842885
D005978	Glutathione	[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde	21842885
D005978	Glutathione	[Glutathione co-treated with [CYP2E1 protein results in increased metabolism of Phenol]] results in increased chemical synthesis of [Glutathione binds to hydroquinone metabolite]	8211999
D005990	Glycerol	Glycerol inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
C071834	glycidamide	[CYP2E1 gene polymorphism co-treated with EPHX1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the abundance of glycidamide	19131562
C071834	glycidamide	[CYP2E1 gene polymorphism co-treated with EPHX1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of glycidamide	19131562
C071834	glycidamide	[CYP2E1 gene polymorphism co-treated with GSTM1 gene polymorphism] affects the abundance of glycidamide	19131562
C071834	glycidamide	[CYP2E1 gene polymorphism co-treated with GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the abundance of glycidamide	19131562
C071834	glycidamide	[CYP2E1 protein results in increased oxidation of Acrylamide] which results in increased abundance of glycidamide	27174446
C071834	glycidamide	[CYP2E1 protein results in increased metabolism of Acrylamide] which results in increased chemical synthesis of glycidamide	25980586
D006034	Glycyrrhetinic Acid	[brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein	21800547
C010974	glyphosate	glyphosate results in increased methylation of CYP2E1 gene	31011160
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CYP2E1 mRNA	24763279
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins results in decreased activity of CYP2E1 protein	12587719
C511402	Grape Seed Proanthocyanidins	CYP2E1 protein results in increased metabolism of Grape Seed Proanthocyanidins	11330834
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins results in decreased activity of CYP2E1 protein	11330834
C511402	Grape Seed Proanthocyanidins	[Grape Seed Proanthocyanidins results in decreased activity of CYP2E1 protein] which results in decreased hydroxylation of aniline	11330834
C412815	GW 4064	[GW 4064 co-treated with Oleic Acid] results in decreased expression of CYP2E1 mRNA	30611723
C412815	GW 4064	GW 4064 results in decreased expression of CYP2E1 mRNA	30611723
D055768	Halogenated Diphenyl Ethers	Halogenated Diphenyl Ethers results in increased expression of CYP2E1 mRNA	26808241
D006221	Halothane	CYP2E1 protein affects the metabolism of Halothane	9103523
D006221	Halothane	CYP2E1 protein results in increased metabolism of Halothane	11684365; 12464242;
D006221	Halothane	CYP2E1 protein results in increased oxidation of Halothane	10805064
D006221	Halothane	Disulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane]	10805064
D006221	Halothane	CYP2E1 protein results in increased susceptibility to Halothane	12803597
D006221	Halothane	CYP2E1 protein results in increased oxidation of Halothane	12803597
D006427	Hemin	Hemin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	19325051
D006427	Hemin	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA]	26747958
D006427	Hemin	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein]	26747958
D006427	Hemin	Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]	26747958
D006427	Hemin	Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]	26747958
C481602	heptylparaben	heptylparaben results in decreased activity of CYP2E1 protein	27432241
C013015	hesperetin	hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein]	19497424
D006581	Hexachlorobenzene	Hexachlorobenzene results in decreased expression of CYP2E1 mRNA	15159207
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of CYP2E1 protein	10696772
D001556	Hexachlorocyclohexane	CYP2E1 protein results in decreased susceptibility to Hexachlorocyclohexane	21458603
D001556	Hexachlorocyclohexane	Hexachlorocyclohexane results in decreased expression of CYP2E1 mRNA	20035023
D001556	Hexachlorocyclohexane	Hexachlorocyclohexane results in increased activity of CYP2E1 protein	12842176; 14631868;
D001556	Hexachlorocyclohexane	Hexachlorocyclohexane results in increased expression of CYP2E1 mRNA	17919674; 17984293; 23927878; 25572523;
D001556	Hexachlorocyclohexane	Hexachlorocyclohexane results in increased expression of CYP2E1 protein	12842176; 14631868; 17919674; 23927878;
C000625836	HFPO4 compound	HFPO4 compound results in decreased expression of CYP2E1 mRNA	27553808
C029424	hydrazine	hydrazine results in increased activity of CYP2E1 protein	15132840
D006854	Hydrocortisone	Hydrocortisone results in increased expression of CYP2E1 mRNA	10476907
D006854	Hydrocortisone	Hydrocortisone results in increased expression of CYP2E1 protein	10476907
D006861	Hydrogen Peroxide	CYP2E1 protein results in increased abundance of Hydrogen Peroxide	25061110
D047348	Hydrolyzable Tannins	Hydrolyzable Tannins results in decreased activity of CYP2E1 protein	12749824
D047348	Hydrolyzable Tannins	Hydrolyzable Tannins results in decreased expression of CYP2E1 protein	12749824
C031927	hydroquinone	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of hydroquinone	15051535
C031927	hydroquinone	hydroquinone results in increased expression of CYP2E1 mRNA	30567741
C031927	hydroquinone	hydroquinone results in increased expression of CYP2E1 protein	30567741
C031927	hydroquinone	PPP2CA protein affects the reaction [hydroquinone results in increased expression of CYP2E1 protein]	30567741
C031927	hydroquinone	PPP2R5A protein affects the reaction [hydroquinone results in increased expression of CYP2E1 mRNA]	30567741
C031927	hydroquinone	PPP2R5A protein affects the reaction [hydroquinone results in increased expression of CYP2E1 protein]	30567741
C031927	hydroquinone	[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone	8211999
C031927	hydroquinone	[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of hydroquinone	8211999
C031927	hydroquinone	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone]	8211999
C031927	hydroquinone	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of hydroquinone]	8211999
C031927	hydroquinone	[Glutathione co-treated with [CYP2E1 protein results in increased metabolism of Phenol]] results in increased chemical synthesis of [Glutathione binds to hydroquinone metabolite]	8211999
C013038	hydroxyhydroquinone	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of hydroxyhydroquinone	15051535
D006923	Hymecromone	Hymecromone inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein]	24661945
C058309	hypaconitine	CYP2E1 protein results in increased metabolism of hypaconitine	21550385
C021304	hyperoside	hyperoside inhibits the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]	26772156
C021304	hyperoside	hyperoside results in decreased activity of CYP2E1 protein	26772156
C029899	imidazole	imidazole results in increased expression of CYP2E1 protein	3337723
D007093	Imidazoles	Imidazoles inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	21600194
C016517	indole-3-carbinol	indole-3-carbinol results in decreased activity of CYP2E1 protein	17582584
D007213	Indomethacin	Indomethacin results in decreased expression of CYP2E1 mRNA	16771604
C015293	indopan	indopan analog results in decreased activity of CYP2E1 protein	26599973
C015293	indopan	[indopan analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
C015293	indopan	indopan results in decreased activity of CYP2E1 protein	26599973
C015293	indopan	[indopan results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D007510	Isatin	Isatin results in increased expression of CYP2E1 mRNA	15056799
C022246	isobutyronitrile	CYP2E1 protein results in increased susceptibility to isobutyronitrile	22051853
C040920	isoliquiritigenin	isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]	25450236
C040920	isoliquiritigenin	isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]	25450236
D007538	Isoniazid	CYP2E1 gene polymorphism affects the susceptibility to Isoniazid	12668988
D007538	Isoniazid	CYP2E1 gene SNP affects the susceptibility to Isoniazid	20485159
D007538	Isoniazid	CYP2E1 protein results in increased metabolism of Isoniazid	17950035
D007538	Isoniazid	CYP2E1 protein results in increased susceptibility to Isoniazid	28762043
D007538	Isoniazid	GSTM1 protein inhibits the reaction [CYP2E1 protein results in increased susceptibility to Isoniazid]	28762043
D007538	Isoniazid	Isoniazid results in increased expression of CYP2E1 protein	8074729
D007538	Isoniazid	Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]	22342832
D007538	Isoniazid	Isoniazid results in increased expression of CYP2E1 mRNA	22342832
D007538	Isoniazid	2-(allylthio)pyrazine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]	9065729
D007538	Isoniazid	diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]	26880746
D007538	Isoniazid	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein	27919644
D007538	Isoniazid	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA	27919644
D007538	Isoniazid	Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D007538	Isoniazid	Isoniazid results in increased activity of CYP2E1 protein	12458634; 15132840; 15205388; 19683030; 23211455; 25683034; 26880746; 9051121; 9129171;
D007538	Isoniazid	[Isoniazid results in increased activity of CYP2E1 protein] which results in increased metabolism of 4-dichlorobenzene	9051121
D007538	Isoniazid	Isoniazid results in increased expression of and results in increased activity of CYP2E1 protein	18754103
D007538	Isoniazid	Isoniazid results in increased expression of CYP2E1	20566340
D007538	Isoniazid	Isoniazid results in increased expression of CYP2E1 mRNA	11752103; 25683034;
D007538	Isoniazid	Isoniazid results in increased expression of CYP2E1 protein	15205388; 15763544; 24929095; 3113478; 9065729;
D007538	Isoniazid	[Isoniazid results in increased expression of CYP2E1] which results in increased metabolism of Acetaminophen	20566340
D007538	Isoniazid	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D007538	Isoniazid	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D007538	Isoniazid	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D007538	Isoniazid	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D007538	Isoniazid	Rifampin inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]	15132840
D007538	Isoniazid	Thiram inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]	12458634
D007538	Isoniazid	Tiopronin inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]	19683030
D007538	Isoniazid	Isoniazid results in decreased activity of CYP2E1 protein	7710944
D007538	Isoniazid	Isoniazid results in increased activity of CYP2E1	12803597
D007538	Isoniazid	Isoniazid results in increased expression of CYP2E1	15890479
D007545	Isoproterenol	Isoproterenol affects the expression of CYP2E1 mRNA	18725507
C028904	isoproturon	isoproturon inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
C028904	isoproturon	isoproturon results in decreased activity of CYP2E1 protein	22634058
D007546	Isoquinolines	Isoquinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	21600194
D007546	Isoquinolines	[CYP2E1 protein co-treated with Acetylcysteine] affects the metabolism of Isoquinolines	21395287
D007559	Ivermectin	Ivermectin results in decreased activity of CYP2E1 protein	18420780
C098607	JP8 aviation fuel	CYP2E1 gene polymorphism affects the susceptibility to JP8 aviation fuel	21961652
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of CYP2E1 mRNA	15618438
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of CYP2E1 protein	15618438
C006552	kaempferol	kaempferol inhibits the reaction [propacetamol results in increased expression of CYP2E1 protein]	29574133
C053401	kahweol	kahweol results in decreased activity of CYP2E1 protein	17590492
D007649	Ketamine	Ketamine results in increased expression of CYP2E1 protein	16076768
D007654	Ketoconazole	Ketoconazole results in decreased activity of CYP2E1 protein	15618748
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA	18544905
D000077213	Lamotrigine	CYP2E1 protein results in increased glutathionylation of Lamotrigine	19961160
D000077213	Lamotrigine	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased glutathionylation of Lamotrigine]	19961160
D007848	Laurates	[CYP2E1 protein co-treated with POR protein] results in increased hydroxylation of Laurates	2292581
C030358	lauric acid	CYP2E1 protein results in increased metabolism of lauric acid	12464242
C052901	lemongrass oil	lemongrass oil affects the expression of CYP2E1 mRNA	25976427
C052901	lemongrass oil	lemongrass oil results in increased expression of CYP2E1 mRNA	25660481
C032854	leupeptin	leupeptin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
C070840	licochalcone A	licochalcone A affects the activity of CYP2E1 protein	26100226
D019787	Linoleic Acid	Linoleic Acid results in decreased activity of CYP2E1 protein	16978661
D008055	Lipids	Lipids inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]	25445725
D008070	Lipopolysaccharides	Lipopolysaccharides affects the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]	16235733
D008070	Lipopolysaccharides	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP2E1 mRNA	22777745
D008070	Lipopolysaccharides	[AQP4 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of CYP2E1 mRNA	20615459
C512196	liquiritin	[brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein	21800547
D008095	Lithocholic Acid	Lithocholic Acid results in decreased activity of CYP2E1 protein	18420780
D047311	Luteolin	Luteolin inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein]	23770416
C520284	Ly-364947	Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]	25566828
C520284	Ly-364947	Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]	25566828
C520284	Ly-364947	Ly-364947 results in increased expression of CYP2E1 mRNA	25566828
D000077276	Lycopene	Lycopene inhibits the reaction [Atrazine results in increased expression of CYP2E1 mRNA]	26775023
D008294	Malathion	Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
D008294	Malathion	Malathion results in decreased activity of CYP2E1 protein	22634058
C015977	malealdehyde	1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]	21842885
C015977	malealdehyde	[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde	21842885
C015977	malealdehyde	[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde	21842885
C015977	malealdehyde	[CYP2E1 protein results in increased metabolism of furan] which results in increased chemical synthesis of malealdehyde	22240984; 24183702;
C037938	mandelic acid	CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]	25562543
D008344	Maneb	[Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA	16510128
D008344	Maneb	Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]	20964710
D008344	Maneb	Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	20964710
D008344	Maneb	[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein	20964710
D008344	Maneb	[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA	20964710
D008344	Maneb	Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]	20964710
D008344	Maneb	Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	20964710
D008344	Maneb	Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D008344	Maneb	Acetylcysteine inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D008344	Maneb	Acetylcysteine inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]	23159886
D008344	Maneb	Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	23159886
D008344	Maneb	[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein	23159886
D008344	Maneb	[Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA	23159886
D008344	Maneb	Maneb results in decreased activity of CYP2E1 protein	11043497
D008344	Maneb	Maneb results in increased activity of CYP2E1 protein	20888808
D008344	Maneb	Maneb results in increased expression of and results in increased activity of CYP2E1 protein	23159886
D008344	Maneb	Maneb results in increased expression of CYP2E1 mRNA	20888808; 23159886;
D008344	Maneb	Maneb results in increased expression of CYP2E1 protein	20888808
D008344	Maneb	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D008344	Maneb	Silymarin inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D008344	Maneb	Silymarin inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]	23159886
D008344	Maneb	Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	23159886
C013592	mangiferin	mangiferin results in decreased activity of CYP2E1 protein	18053976
D008550	Melatonin	Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]	20964710
D008550	Melatonin	Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	20964710
D008550	Melatonin	Melatonin inhibits the reaction [Benzene results in increased activity of CYP2E1 protein]	20338863
D008617	Mephenytoin	Mephenytoin results in decreased activity of CYP2E1 protein	18420780
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of CYP2E1 mRNA	22792809
D008687	Metformin	Metformin results in increased expression of CYP2E1 mRNA	22342832
C008385	methacrylonitrile	CYP2E1 protein results in increased metabolism of methacrylonitrile	10215687
C008385	methacrylonitrile	[CYP2E1 protein results in increased metabolism of methacrylonitrile] which results in increased abundance of Cyanides	15893539
C008385	methacrylonitrile	methacrylonitrile results in increased activity of CYP2E1 protein	11939710
C008385	methacrylonitrile	methacrylonitrile results in increased expression of CYP2E1 mRNA	11939710
C008385	methacrylonitrile	methacrylonitrile results in increased expression of CYP2E1 protein	11939710
D008694	Methamphetamine	CYP2E1 protein affects the metabolism of Methamphetamine metabolite	16038959
D008701	Methapyrilene	Methapyrilene results in decreased expression of CYP2E1 mRNA	28935588
D008701	Methapyrilene	Methapyrilene results in decreased expression of CYP2E1 mRNA	30467583
D008715	Methionine	[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	20118189
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYP2E1 mRNA	22872676
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased activity of CYP2E1 protein	18952117
D008715	Methionine	RXRA gene mutant form inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of CYP2E1 protein]	18952117
D008715	Methionine	geraniol inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CYP2E1 protein]	26695085
D008715	Methionine	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D008715	Methionine	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CYP2E1 protein	26695085
D008715	Methionine	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D008715	Methionine	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D008730	Methoxsalen	Methoxsalen results in decreased activity of CYP2E1 protein	18420780
D008730	Methoxsalen	Methoxsalen results in decreased activity of CYP2E1 protein	15879494
D008731	Methoxychlor	Methoxychlor results in decreased activity of CYP2E1 protein	18420780
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in increased expression of CYP2E1 mRNA	21782745
D008731	Methoxychlor	Methoxychlor results in increased expression of and results in increased activity of CYP2E1 protein	12919727
D008731	Methoxychlor	Methoxychlor results in increased expression of CYP2E1 mRNA	21782745
D008732	Methoxydimethyltryptamines	Methoxydimethyltryptamines analog results in decreased activity of CYP2E1 protein	26599973
D008732	Methoxydimethyltryptamines	[Methoxydimethyltryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
D008733	Methoxyflurane	CYP2E1 protein results in increased metabolism of Methoxyflurane	7879937
D008737	Methyl Chloride	CYP2E1 protein results in increased oxidation of Methyl Chloride	1664256
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of CYP2E1 mRNA	28673560
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of CYP2E1 mRNA	30503582
D008748	Methylcholanthrene	[Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA	8734847
D008748	Methylcholanthrene	[Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein	8734847
D008748	Methylcholanthrene	[Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein	8734847
D008748	Methylcholanthrene	[Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein	8734847
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [CYP2E1 protein results in increased oxidation of Toluene]	1994898
D008748	Methylcholanthrene	Methylcholanthrene results in decreased activity of CYP2E1 protein	8734847
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of CYP2E1 mRNA	7493548; 8734847;
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of CYP2E1 protein	3113478; 8734847; 9118891;
D008748	Methylcholanthrene	[Methylcholanthrene results in decreased expression of CYP2E1 protein] which affects the metabolism of Benzene	9118891
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of CYP2E1 mRNA	19889059; 23273579;
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of CYP2E1 protein	10476907; 19889059;
D008748	Methylcholanthrene	[protocatechuic acid co-treated with Methylcholanthrene] results in decreased activity of CYP2E1 protein	15302093
D008748	Methylcholanthrene	[pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA	8734847
D008748	Methylcholanthrene	[pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein	8734847
D008748	Methylcholanthrene	[pyridine co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein	8734847
D008748	Methylcholanthrene	[pyridine co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein	8734847
D008752	Methylene Chloride	CYP2E1 protein results in increased oxidation of Methylene Chloride	1664256
D008752	Methylene Chloride	3-xylene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]	8889796
D008752	Methylene Chloride	Benzene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]	8889796
D008752	Methylene Chloride	CYP2E1 protein results in increased metabolism of Methylene Chloride	8889796
D008752	Methylene Chloride	Toluene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]	8889796
C005222	methylethyl ketone	CYP2E1 gene mutant form affects the susceptibility to methylethyl ketone	21352904
C017510	methylethylnitrosamine	CYP2E1 protein affects the metabolism of and results in increased activity of methylethylnitrosamine	11600130
C002950	methylformamide	CYP2E1 protein results in increased metabolism of methylformamide	1538706
C002950	methylformamide	4-nitrophenol inhibits the reaction [CYP2E1 protein results in increased metabolism of methylformamide]	1538706
C002950	methylformamide	Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein results in increased metabolism of methylformamide]	1538706
C002950	methylformamide	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of methylformamide]	1538706
C002950	methylformamide	Fomepizole promotes the reaction [CYP2E1 protein results in increased metabolism of methylformamide]	1538706
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of CYP2E1 mRNA	22792809
D008777	Methyltestosterone	[Methyltestosterone co-treated with Cholic Acids] affects the expression of CYP2E1 mRNA	27344345
D008795	Metronidazole	[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2E1 mRNA	30545405
D008874	Midazolam	CYP2E1 protein results in increased metabolism of Midazolam	17590308
D008917	Mirex	Mirex results in decreased expression of CYP2E1 protein	3113478
C502230	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]	12086689
C502230	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin promotes the reaction [CYP2E1 protein results in increased susceptibility to Buthionine Sulfoximine]	12086689
C000627226	momfluorothrin	momfluorothrin results in decreased expression of CYP2E1 mRNA	28520973
C028577	monobutyl phthalate	monobutyl phthalate results in decreased activity of CYP2E1 protein	27432241
D008999	Monocrotophos	[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein	22733800
D008999	Monocrotophos	Monocrotophos results in increased activity of CYP2E1 protein	22733800
D008999	Monocrotophos	Monocrotophos results in increased expression of CYP2E1 mRNA	22733800
D008999	Monocrotophos	Monocrotophos results in increased expression of CYP2E1 protein	22733800
D008999	Monocrotophos	[Rifampin co-treated with Monocrotophos] results in increased activity of CYP2E1 protein	22733800
D008999	Monocrotophos	[Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 mRNA	22733800
D008999	Monocrotophos	[Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 protein	22733800
D008999	Monocrotophos	Monocrotophos results in increased expression of CYP2E1 protein	21445290
C005939	muconic acid	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of muconic acid	15051535
C040015	myricetin	myricetin results in decreased activity of CYP2E1 protein	29753067
C008577	myricitrin	myricitrin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]	25656916
C534983	N-(2-amino-3-methyl-n-butyl)-3-((bis-4-fluorophenyl)methoxy)tropane	CYP2E1 protein results in increased metabolism of N-(2-amino-3-methyl-n-butyl)-3-((bis-4-fluorophenyl)methoxy)tropane	18425847
C028473	N-acetyl-4-benzoquinoneimine	CYP2E1 protein results in increased abundance of N-acetyl-4-benzoquinoneimine	24661219
C028473	N-acetyl-4-benzoquinoneimine	CYP2E1 results in increased chemical synthesis of N-acetyl-4-benzoquinoneimine	20566340
C028473	N-acetyl-4-benzoquinoneimine	CYP2E1 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine	19679878
C028473	N-acetyl-4-benzoquinoneimine	CYP2E1 protein results in increased abundance of N-acetyl-4-benzoquinoneimine	20166895; 20404090; 24552538;
C028473	N-acetyl-4-benzoquinoneimine	CYP2E1 protein results in increased chemical synthesis of N-acetyl-4-benzoquinoneimine	20423716
D009249	NADP	[vinyl carbamate co-treated with NADP] inhibits the reaction [CYP2E1 protein results in decreased methylation of Dimethylnitrosamine]	11181492
D009249	NADP	[2-dichlorobenzene analog co-treated with NADP] results in decreased activity of CYP2E1 protein	24713513
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of CYP2E1 mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of CYP2E1 mRNA	25554681
C031721	naphthalene	naphthalene results in increased expression of CYP2E1 mRNA	20500019
C461488	N-benzylpiperazine	N-benzylpiperazine results in decreased expression of CYP2E1 mRNA	26821219
C051752	nefazodone	nefazodone results in increased expression of CYP2E1 mRNA	24136188
C057222	neferine	neferine inhibits the reaction [Diethylnitrosamine results in increased expression of CYP2E1 mRNA]	30423403
D009355	Neomycin	[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2E1 mRNA	30545405
C026385	n-hexane	CYP2E1 gene polymorphism affects the susceptibility to n-hexane	16484137
C026385	n-hexane	CYP2E1 protein results in increased hydroxylation of n-hexane	16484137
C026385	n-hexane	CYP2E1 protein results in increased metabolism of n-hexane	11201664
C026385	n-hexane	diallyl trisulfide inhibits the reaction [n-hexane results in increased expression of and results in increased activity of CYP2E1 protein]	28115069
C026385	n-hexane	n-hexane results in increased expression of and results in increased activity of CYP2E1 protein	28115069
D009536	Niacinamide	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D009536	Niacinamide	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
C028007	nickel monoxide	nickel monoxide results in decreased expression of CYP2E1 mRNA	19167457
D009538	Nicotine	Nicotine results in increased expression of CYP2E1 protein	16368115
D009538	Nicotine	Nicotine results in increased expression of CYP2E1 protein	16434548
D009538	Nicotine	Nicotine results in decreased activity of CYP2E1 protein	25221795
D009543	Nifedipine	Nifedipine results in decreased activity of CYP2E1 protein	18420780
D009569	Nitric Oxide	[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Nitric Oxide	18845238
D005996	Nitroglycerin	Nitroglycerin results in increased expression of CYP2E1 mRNA	12102619
D009602	Nitrosamines	[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Nitrosamines	11733072
D009602	Nitrosamines	CYP2E1 protein results in increased metabolism of and results in increased activity of Nitrosamines	16470306
C014707	nitrosobenzylmethylamine	CYP2E1 protein affects the metabolism of nitrosobenzylmethylamine	2655891
C014707	nitrosobenzylmethylamine	CYP2E1 protein results in increased metabolism of nitrosobenzylmethylamine	10616189
C014707	nitrosobenzylmethylamine	[Ethanol co-treated with nitrosobenzylmethylamine] results in increased expression of CYP2E1 protein	16704527
D018817	N-Methyl-3,4-methylenedioxyamphetamine	N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CYP2E1 mRNA	26251327
C468271	N-methyl-N-benzylnitrosamine	N-methyl-N-benzylnitrosamine results in decreased activity of CYP2E1 protein	12222751
C014102	N-methyl-N-nitrosoaniline	CYP2E1 protein affects the metabolism of N-methyl-N-nitrosoaniline	15815077
C014102	N-methyl-N-nitrosoaniline	N-methyl-N-nitrosoaniline binds to CYP2E1 protein	15815077
C578955	N,N-diallyl-5-methoxytryptamine	N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2E1 protein	26599973
C578955	N,N-diallyl-5-methoxytryptamine	[N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
C454677	N,N-diethyl-3-hydroxymethylbenzamide	CYP2E1 protein results in increased chemical synthesis of N,N-diethyl-3-hydroxymethylbenzamide	11854147
C033695	N,N-diisopropyltryptamine	N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein	26599973
C033695	N,N-diisopropyltryptamine	[N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
C014129	N-nitrosodiethanolamine	CYP2E1 protein results in increased metabolism of N-nitrosodiethanolamine	18616954
C013161	N-nitroso(di-n-propyl)amine	CYB5A protein promotes the reaction [CYP2E1 protein results in increased activity of N-nitroso(di-n-propyl)amine]	15728263
C013161	N-nitroso(di-n-propyl)amine	CYP2E1 protein affects the metabolism of N-nitroso(di-n-propyl)amine	10910959
C013161	N-nitroso(di-n-propyl)amine	[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to N-nitroso(di-n-propyl)amine	11733072
C013161	N-nitroso(di-n-propyl)amine	[CYP2E1 protein co-treated with POR protein] results in increased susceptibility to N-nitroso(di-n-propyl)amine	11035158
C013161	N-nitroso(di-n-propyl)amine	CYP2E1 protein results in increased activity of N-nitroso(di-n-propyl)amine	15728263
C013161	N-nitroso(di-n-propyl)amine	CYP2E1 protein results in decreased nitrosation of N-nitroso(di-n-propyl)amine	10910959
C013161	N-nitroso(di-n-propyl)amine	CYP2E1 protein results in increased metabolism of N-nitroso(di-n-propyl)amine	8625499
C002741	N-nitrosomorpholine	CYP2E1 protein affects the metabolism of and results in increased activity of N-nitrosomorpholine	11774366
C002743	N-nitrosopiperidine	CYP2E1 protein affects the metabolism of and results in increased activity of N-nitrosopiperidine	11774366
D009242	N-Nitrosopyrrolidine	CYP2E1 protein affects the metabolism of and results in increased activity of N-Nitrosopyrrolidine	11774366
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with Pioglitazone] results in decreased expression of CYP2E1 mRNA	27935865
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CYP2E1 mRNA	27935865
C093285	NOC 18	NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2E1 mRNA]	18206661
C063006	norflurane	4-nitrophenol inhibits the reaction [CYP2E1 protein results in increased oxidation of norflurane]	1356728
C063006	norflurane	CYP2E1 protein results in increased oxidation of norflurane	1356728
C010262	norharman	CYP2E1 protein affects the metabolism of [norharman co-treated with aniline]	15279827
C041288	n-propyl disulfide	n-propyl disulfide results in decreased activity of CYP2E1 protein	18339364
C464660	obeticholic acid	obeticholic acid results in decreased expression of CYP2E1 mRNA	27939613
C025589	ochratoxin A	CYP2E1 protein results in increased susceptibility to ochratoxin A	11189750
D019319	Okadaic Acid	Okadaic Acid results in decreased expression of CYP2E1 mRNA	25270620
D009828	Oleanolic Acid	Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]	10355542
D009828	Oleanolic Acid	Oleanolic Acid results in decreased expression of CYP2E1 mRNA	18706400
D009828	Oleanolic Acid	Oleanolic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	25111957
D019301	Oleic Acid	[6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Oleic Acid] results in increased expression of CYP2E1 mRNA	30611723
D019301	Oleic Acid	[Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2E1 mRNA	30611723
D019301	Oleic Acid	Farnesol analog inhibits the reaction [Oleic Acid results in increased expression of CYP2E1 mRNA]	30611723
D019301	Oleic Acid	[GW 4064 co-treated with Oleic Acid] results in decreased expression of CYP2E1 mRNA	30611723
D019301	Oleic Acid	Oleic Acid results in increased expression of CYP2E1 mRNA	30611723
D019301	Oleic Acid	Ethanol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CYP2E1 mRNA]	26854922
D019301	Oleic Acid	[Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	26854922
D019301	Oleic Acid	[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CYP2E1 mRNA	26854922
C026209	oltipraz	oltipraz affects the activity of CYP2E1 protein	10775323
D009853	Omeprazole	Omeprazole results in increased expression of and results in increased activity of CYP2E1 protein	15802389
D009764	o-Phthalaldehyde	o-Phthalaldehyde results in decreased expression of CYP2E1 mRNA	20112102
D009966	Orphenadrine	Orphenadrine inhibits the reaction [CYP2E1 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]	9241656
D009966	Orphenadrine	Orphenadrine inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]	9241656
D009966	Orphenadrine	Orphenadrine results in decreased activity of CYP2E1 protein	9241656
D010098	Oxycodone	Oxycodone results in increased expression of CYP2E1 mRNA	23439660
D010100	Oxygen	Oxygen deficiency results in decreased expression of CYP2E1 mRNA	19695866
D010100	Oxygen	Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]	26747958
D010100	Oxygen	Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]	26747958
D010100	Oxygen	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA]	26747958
D010100	Oxygen	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein]	26747958
D010100	Oxygen	Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]	26747958
D010100	Oxygen	Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]	26747958
D010100	Oxygen	[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 mRNA	26747958
D010100	Oxygen	[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 protein	26747958
D010100	Oxygen	[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA	26747958
D010100	Oxygen	[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein	26747958
D010100	Oxygen	[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA	26747958
D010100	Oxygen	[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein	26747958
D010100	Oxygen	zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]	26747958
D010100	Oxygen	zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]	26747958
D010126	Ozone	Ozone results in decreased expression of CYP2E1 mRNA	12763052
D017239	Paclitaxel	Paclitaxel results in decreased activity of CYP2E1 protein	24882083
D017239	Paclitaxel	turmeric extract affects the reaction [Paclitaxel results in decreased activity of CYP2E1 protein]	24882083
D019308	Palmitic Acid	Ethanol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CYP2E1 mRNA]	26854922
D019308	Palmitic Acid	[Oleic Acid co-treated with Palmitic Acid] inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	26854922
D019308	Palmitic Acid	[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CYP2E1 mRNA	26854922
D000073878	Palm Oil	Palm Oil results in decreased expression of CYP2E1 mRNA	18042831
D010269	Paraquat	[Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA	16510128
D010269	Paraquat	Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]	20964710
D010269	Paraquat	Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	20964710
D010269	Paraquat	[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein	20964710
D010269	Paraquat	[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA	20964710
D010269	Paraquat	Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]	20964710
D010269	Paraquat	Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	20964710
D010269	Paraquat	Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D010269	Paraquat	Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	23159886
D010269	Paraquat	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D010269	Paraquat	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CYP2E1 mRNA]	23159886
D010269	Paraquat	[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein	23159886
D010269	Paraquat	[Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA	23159886
D010269	Paraquat	Paraquat promotes the reaction [Zinc Sulfate results in increased expression of CYP2E1 mRNA]	20553223
D010269	Paraquat	Paraquat results in increased activity of CYP2E1 protein	20888808
D010269	Paraquat	Paraquat results in increased expression of and results in increased activity of CYP2E1 protein	23159886
D010269	Paraquat	Paraquat results in increased expression of CYP2E1 mRNA	20553223; 20888808; 23159886;
D010269	Paraquat	Paraquat results in increased expression of CYP2E1 protein	20888808
D010269	Paraquat	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D010269	Paraquat	Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	23159886
D010269	Paraquat	Silymarin inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D010269	Paraquat	Silymarin inhibits the reaction [Paraquat results in increased expression of CYP2E1 mRNA]	23159886
D010269	Paraquat	Zinc Sulfate promotes the reaction [Paraquat results in increased expression of CYP2E1 mRNA]	20553223
D010278	Parathion	CYP2E1 protein affects the metabolism of Parathion	12669189
D052638	Particulate Matter	Particulate Matter results in increased expression of CYP2E1 mRNA	18952161
D052638	Particulate Matter	Particulate Matter results in increased expression of CYP2E1 mRNA	22352393; 24216475;
D010396	Penicillamine	Penicillamine results in increased expression of CYP2E1 mRNA	22843330
C003060	pentachlorobenzene	CYP2E1 protein results in increased metabolism of pentachlorobenzene	7747284
C003060	pentachlorobenzene	CYP2E1 protein results in increased oxidation of pentachlorobenzene	7747284
C003060	pentachlorobenzene	pentachlorobenzene results in increased expression of CYP2E1 protein	10696772
D010416	Pentachlorophenol	CYP2E1 protein results in increased oxidation of Pentachlorophenol	7747284
D010416	Pentachlorophenol	Pentachlorophenol inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-hydroxymethylpyrene] which results in increased mutagenesis of HPRT1 gene]	25243916
D010416	Pentachlorophenol	Pentachlorophenol inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene]	25243916
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid inhibits the reaction [CYP2E1 protein results in increased oxidation of Chlorzoxazone]	21964418
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of CYP2E1 mRNA	19429403
C023036	perfluorooctanoic acid	Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of CYP2E1 mRNA]	23626681
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of CYP2E1 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CYP2E1 mRNA	17681415
D010575	Pesticides	CYP2E1 gene polymorphism affects the susceptibility to Pesticides	18550589
D010575	Pesticides	CYP2E1 protein results in decreased susceptibility to Pesticides	21458603
D010575	Pesticides	CYP2E1 protein results in increased susceptibility to Pesticides	18550589
D010615	Phenacetin	CYP2E1 protein affects the metabolism of Phenacetin	15879494
C031181	phenanthrene	CYP2E1 protein results in increased metabolism of and results in increased activity of phenanthrene	19766613
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased activity of CYP2E1 protein	10616189; 17582584;
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]	7601153
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]	7601153
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde]	7562599
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	7562599
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	7562599
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of CYP2E1 protein	7601153
D010629	Phenformin	Phenformin results in increased expression of CYP2E1 mRNA	31324951
D010634	Phenobarbital	Phenobarbital results in decreased expression of CYP2E1 mRNA	19952500
D010634	Phenobarbital	Phenobarbital results in decreased expression of CYP2E1 mRNA	30503582
D010634	Phenobarbital	Choline deficiency promotes the reaction [Phenobarbital results in increased expression of CYP2E1 protein]	18798224
D010634	Phenobarbital	[Phenobarbital co-treated with beta-Naphthoflavone] results in decreased expression of CYP2E1 protein	30842367
D010634	Phenobarbital	Phenobarbital results in decreased expression of CYP2E1 mRNA	15596064; 17381134;
D010634	Phenobarbital	Phenobarbital results in decreased expression of CYP2E1 protein	30842367; 9118891;
D010634	Phenobarbital	Phenobarbital results in increased activity of CYP2E1 protein	15490126
D010634	Phenobarbital	Phenobarbital results in increased expression of CYP2E1 mRNA	23273579
D010634	Phenobarbital	Phenobarbital results in increased expression of CYP2E1 protein	18798224
D019800	Phenol	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of Phenol	15051535
D019800	Phenol	CYP2E1 protein results in increased metabolism of Phenol	11701230
D019800	Phenol	[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of Phenol	8211999
D019800	Phenol	CYP2E1 protein results in increased metabolism of Phenol	8211999
D019800	Phenol	[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of catechol	8211999
D019800	Phenol	[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of hydroquinone	8211999
D019800	Phenol	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of Phenol]	8211999
D019800	Phenol	EPHX1 protein promotes the reaction [CYP2E1 protein results in increased metabolism of Phenol]	8211999
D019800	Phenol	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of catechol]	8211999
D019800	Phenol	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of hydroquinone]	8211999
D019800	Phenol	[Glutathione co-treated with [CYP2E1 protein results in increased metabolism of Phenol]] results in increased chemical synthesis of [Glutathione binds to hydroquinone metabolite]	8211999
C008838	phenthoate	phenthoate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
C008838	phenthoate	phenthoate results in decreased activity of CYP2E1 protein	22634058
D010626	Phenylethyl Alcohol	CYP2E1 protein results in increased oxidation of Phenylethyl Alcohol	7515681
C012482	phenylglyoxylic acid	CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]	25562543
D010672	Phenytoin	NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2E1 mRNA]	18206661
D010672	Phenytoin	Phenytoin results in increased expression of CYP2E1 mRNA	18206661
D010672	Phenytoin	Phenytoin results in increased expression of CYP2E1 protein	18206661
D010672	Phenytoin	Phenytoin results in decreased expression of CYP2E1 mRNA	17381134
D000077205	Pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with Pioglitazone] results in decreased expression of CYP2E1 mRNA	27935865
C448623	pipermethystine	pipermethystine results in increased expression of CYP2E1 protein	17329236
D010936	Plant Extracts	Plant Extracts results in decreased activity of CYP2E1 protein	15900287; 20828605;
D010936	Plant Extracts	Plant Extracts results in decreased expression of CYP2E1 mRNA	24446304
D010936	Plant Extracts	Plant Extracts results in increased activity of CYP2E1 protein	15974642
D010936	Plant Extracts	Plant Extracts results in increased expression of CYP2E1 mRNA	15629189
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	23279844; 23994094;
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	28797650
D010936	Plant Extracts	Plant Extracts affects the activity of CYP2E1 protein	31059744
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	21224420; 29129047;
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	21224420
D010936	Plant Extracts	Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CYP2E1 protein]	19551842
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	22525864
D010936	Plant Extracts	Plant Extracts promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]	26332274
D010936	Plant Extracts	Plant Extracts results in decreased expression of CYP2E1 mRNA	15242186
D010936	Plant Extracts	Plant Extracts results in increased expression of CYP2E1 mRNA	20521779; 26332274;
D010936	Plant Extracts	Plant Extracts results in increased expression of CYP2E1 protein	20521779
D010938	Plant Oils	Plant Oils inhibits the reaction [emamectin benzoate results in increased expression of CYP2E1 mRNA]	29268245
D028321	Plant Preparations	Plant Preparations results in increased expression of CYP2E1 mRNA	22499231
D028321	Plant Preparations	[Estradiol co-treated with Plant Preparations] results in decreased expression of CYP2E1 mRNA	26945725
D028321	Plant Preparations	Plant Preparations results in decreased activity of CYP2E1 protein	27697540
D028321	Plant Preparations	Plant Preparations results in decreased expression of CYP2E1 mRNA	26945725; 27697540;
D028321	Plant Preparations	Plant Preparations results in increased expression of CYP2E1 mRNA	18047722
D028321	Plant Preparations	Plant Preparations results in increased expression of CYP2E1 mRNA	21056093
D059808	Polyphenols	Polyphenols results in decreased expression of CYP2E1 mRNA	19370779
D059808	Polyphenols	Polyphenols results in decreased expression of CYP2E1 protein	19370779
D059808	Polyphenols	Polyphenols results in decreased expression of CYP2E1 mRNA	16293270
D011134	Polysaccharides	Polysaccharides results in decreased activity of CYP2E1 protein	17827724
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of CYP2E1 mRNA	23608068
D011319	Primaquine	[CYP2E1 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine	19616568
D011319	Primaquine	CYP2E1 protein results in increased metabolism of Primaquine	19616568
D011335	Proadifen	Proadifen inhibits the reaction [CYP2E1 protein results in increased metabolism of aniline]	8819299
D011335	Proadifen	Proadifen results in decreased activity of CYP2E1 protein	15618748
C045362	prochloraz	prochloraz results in decreased expression of CYP2E1 mRNA	20035023
C035988	procymidone	procymidone results in increased expression of and results in increased activity of CYP2E1 protein	12787915
C035988	procymidone	procymidone results in increased expression of CYP2E1 mRNA	12787915
C024273	profenofos	profenofos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	22634058
C024273	profenofos	profenofos results in decreased activity of CYP2E1 protein	22634058
D011374	Progesterone	Progesterone affects the expression of CYP2E1 mRNA	17251523
D011374	Progesterone	Progesterone results in decreased expression of CYP2E1 mRNA	19690047
D011374	Progesterone	Progesterone promotes the reaction [Benzene results in decreased activity of CYP2E1 protein]	18407866
C063776	propacetamol	kaempferol inhibits the reaction [propacetamol results in increased expression of CYP2E1 protein]	29574133
C063776	propacetamol	propacetamol results in increased expression of CYP2E1 protein	29574133
C028255	propargyl alcohol	CYP2E1 protein results in increased metabolism of propargyl alcohol	11306107
C035967	propetamphos	[cypermethrin co-treated with propetamphos] results in increased activity of CYP2E1 protein	25926273
C035967	propetamphos	propetamphos results in increased activity of CYP2E1 protein	25926273
C045950	propiconazole	propiconazole results in decreased expression of CYP2E1 protein	7986207
D011429	Propolis	Propolis inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2E1 protein]	17410408
C004765	propylene dichloride	CYP2E1 protein results in increased oxidation of propylene dichloride	1664256
C006068	propylparaben	propylparaben results in decreased activity of CYP2E1 protein	27432241
C009091	protocatechuic acid	[protocatechuic acid co-treated with Methylcholanthrene] results in decreased activity of CYP2E1 protein	15302093
C009091	protocatechuic acid	protocatechuic acid results in decreased activity of CYP2E1 protein	15302093
C033607	puerarin	puerarin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]	18038910
C033607	puerarin	puerarin results in increased expression of CYP2E1 protein	18038910
C511975	purpurin	purpurin results in decreased activity of CYP2E1 protein	12379470
C026133	purpurogallin	purpurogallin inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D011718	Pyrazinamide	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein	27919644
D011718	Pyrazinamide	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA	27919644
D011718	Pyrazinamide	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D011718	Pyrazinamide	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D011718	Pyrazinamide	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D011718	Pyrazinamide	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D011719	Pyrazines	allyl sulfide inhibits the reaction [Pyrazines results in increased activity of CYP2E1 protein]	8117321
D011719	Pyrazines	allyl sulfide inhibits the reaction [Pyrazines results in increased expression of CYP2E1 protein]	8117321
D011719	Pyrazines	Pyrazines results in increased activity of CYP2E1 protein	8117321
D011719	Pyrazines	Pyrazines results in increased expression of CYP2E1 protein	8117321
C031280	pyrazole	pyrazole results in increased expression of CYP2E1 protein	8074729
C031280	pyrazole	pyrazole affects the expression of CYP2E1 protein	19679878
C031280	pyrazole	pyrazole results in increased expression of CYP2E1 protein	9698299
C031280	pyrazole	pyrazole results in increased activity of CYP2E1 protein	3782137; 8734847;
C031280	pyrazole	pyrazole results in increased expression of CYP2E1 protein	3113478; 3782137; 8734847;
C031280	pyrazole	pyrazole results in increased activity of CYP2E1 protein	10995255
D011720	Pyrazoles	Pyrazoles inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	21600194
C030984	pyrene	pyrene results in decreased expression of CYP2E1 mRNA	30240548
C023666	pyridine	CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]	12147272
C023666	pyridine	Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]]	12147272
C023666	pyridine	pyridine results in decreased activity of CYP2E1 protein	12464242
C023666	pyridine	pyridine results in increased expression of CYP2E1 protein	8074729
C023666	pyridine	pyridine results in increased expression of CYP2E1 protein	8246169
C023666	pyridine	Cycloheximide inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]	1968335
C023666	pyridine	Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP2E1 protein]	1968335
C023666	pyridine	Ditiocarb inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]	9618253
C023666	pyridine	INS protein affects the reaction [pyridine results in increased expression of CYP2E1 protein]	10215695
C023666	pyridine	[pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA	8734847
C023666	pyridine	[pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein	8734847
C023666	pyridine	[pyridine co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein	8734847
C023666	pyridine	[pyridine co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein	8734847
C023666	pyridine	pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2E1 protein]	7587954
C023666	pyridine	pyridine promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	9618253
C023666	pyridine	pyridine results in increased activity of CYP2E1 protein	11181506; 12919724; 1610360; 1968335; 23211455; 8246169; 8734847; 9618253;
C023666	pyridine	pyridine results in increased expression of CYP2E1 mRNA	1379807; 2241968;
C023666	pyridine	pyridine results in increased expression of CYP2E1 protein	10215695; 11181506; 12919724; 1379807; 1610360; 1968335; 2241968; 7587954; 8246169; 8734847; 9618253;
C013229	pyridine N-oxide	pyridine N-oxide results in increased expression of CYP2E1 protein	1379807
D011725	Pyridines	Pyridines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	21600194
D011748	Pyrogallol	Pyrogallol results in increased activity of CYP2E1 protein	18789925
D011748	Pyrogallol	Pyrogallol results in increased expression of CYP2E1 mRNA	18789925
D011748	Pyrogallol	Resveratrol inhibits the reaction [Pyrogallol results in increased activity of CYP2E1 protein]	18789925
D011748	Pyrogallol	Resveratrol inhibits the reaction [Pyrogallol results in increased expression of CYP2E1 mRNA]	18789925
D011791	Quartz	Quartz results in decreased expression of CYP2E1 mRNA	19836432
D011794	Quercetin	Quercetin inhibits the reaction [[CYP2E1 protein results in increased susceptibility to Docosahexaenoic Acids] which results in increased phosphorylation of MAP2K4 protein]	16963249
D011794	Quercetin	Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	19325051
D011794	Quercetin	Quercetin results in decreased activity of CYP2E1 protein	28232125; 29753067;
D011794	Quercetin	zinc protoporphyrin inhibits the reaction [Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]]	19325051
D011794	Quercetin	Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	26218279
D011794	Quercetin	Quercetin results in decreased activity of CYP2E1 protein	18420780
D011794	Quercetin	Quercetin inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D011794	Quercetin	Quercetin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]	11306697
D011794	Quercetin	Quercetin promotes the reaction [Dexamethasone results in increased expression of CYP2E1 mRNA]	20501703
D011794	Quercetin	Quercetin promotes the reaction [Dexamethasone results in increased expression of CYP2E1 protein]	20501703
D011796	Quinacrine	Quinacrine binds to and results in decreased activity of CYP2E1 protein	18754103
D011796	Quinacrine	Quinacrine results in decreased expression of CYP2E1 protein	18754103
D011802	Quinidine	Quinidine results in decreased activity of CYP2E1 protein	18420780
C037219	quinoline	CYP2E1 protein results in increased hydroxylation of quinoline	8824525
D011804	Quinolines	Quinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]	21600194
C004532	quinone	quinone results in decreased expression of CYP2E1 protein	10462055
D017382	Reactive Oxygen Species	CYP2E1 protein results in increased chemical synthesis of Reactive Oxygen Species	10498651
D017382	Reactive Oxygen Species	[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species	18845238
D017382	Reactive Oxygen Species	[Ethanol co-treated with CYP2E1 protein] results in increased abundance of Reactive Oxygen Species	22222162
D017382	Reactive Oxygen Species	Fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species]	18845238
D017382	Reactive Oxygen Species	[CYP2E1 protein results in increased hydroxylation of 4-biphenylamine] which results in increased abundance of Reactive Oxygen Species	25601990
D017382	Reactive Oxygen Species	CYP2E1 protein affects the chemical synthesis of Reactive Oxygen Species	14693714
D017382	Reactive Oxygen Species	CYP2E1 protein results in decreased susceptibility to Reactive Oxygen Species	12470497
D012116	Resins, Plant	Resins, Plant results in increased expression of CYP2E1 mRNA	30251054
D000077185	Resveratrol	Resveratrol analog results in decreased activity of CYP2E1 protein	16684708
D000077185	Resveratrol	Resveratrol inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]	25956474
D000077185	Resveratrol	Resveratrol inhibits the reaction [Pyrogallol results in increased activity of CYP2E1 protein]	18789925
D000077185	Resveratrol	Resveratrol inhibits the reaction [Pyrogallol results in increased expression of CYP2E1 mRNA]	18789925
D000077185	Resveratrol	Resveratrol results in decreased activity of CYP2E1 protein	18420780; 25956474; 27174446;
D000077185	Resveratrol	Resveratrol results in increased expression of CYP2E1 mRNA	22610192
D000077185	Resveratrol	Resveratrol affects the expression of CYP2E1 mRNA	15748624
C009166	retinol acetate	[LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of CYP2E1 mRNA	28123100
C003300	retrorsine	retrorsine results in increased expression of CYP2E1	24799337
C013672	riddelliine	riddelliine results in increased expression of CYP2E1 mRNA	18047722; 18047727;
D012293	Rifampin	[Rifampin co-treated with Monocrotophos] results in increased activity of CYP2E1 protein	22733800
D012293	Rifampin	[Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 mRNA	22733800
D012293	Rifampin	[Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 protein	22733800
D012293	Rifampin	Rifampin results in decreased expression of CYP2E1 mRNA	22258563
D012293	Rifampin	Rifampin results in increased activity of CYP2E1 protein	18071298
D012293	Rifampin	Rifampin results in increased expression of CYP2E1 mRNA	18071298; 22733800;
D012293	Rifampin	Rifampin results in increased expression of CYP2E1 protein	22733800
D012293	Rifampin	[[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in decreased expression of CYP2E1 protein	25835148
D012293	Rifampin	Rifampin results in decreased expression of CYP2E1 mRNA	30503582
D012293	Rifampin	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein	27919644
D012293	Rifampin	[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA	27919644
D012293	Rifampin	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D012293	Rifampin	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D012293	Rifampin	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D012293	Rifampin	Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D012293	Rifampin	Rifampin inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]	15132840
D000077154	Rosiglitazone	Rosiglitazone results in increased expression of CYP2E1 mRNA	21515302
C547390	rossicaside B	rossicaside B inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2E1 protein]	19793341
D012402	Rotenone	Rotenone results in increased expression of CYP2E1 mRNA	28374803
C547130	(S)-2-methylbutyronitrile	CYP2E1 protein results in increased susceptibility to (S)-2-methylbutyronitrile	22051853
D012436	S-Adenosylmethionine	S-Adenosylmethionine results in decreased activity of CYP2E1 protein	15763544
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]	22683606
D012436	S-Adenosylmethionine	S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein]	15983038
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]	15763544
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]	15763544
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol]	15763544
D012451	Safrole	Safrole results in decreased activity of CYP2E1 protein	15778010
C018142	saiko-keishi-to	saiko-keishi-to results in increased expression of CYP2E1 mRNA	14607025
C076944	salvianolic acid B	salvianolic acid B inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	27989594
D012503	Saponins	Saponins inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]	23994094
D012503	Saponins	Saponins results in decreased expression of CYP2E1 mRNA	26590097
C081294	satraplatin	satraplatin results in decreased activity of CYP2E1 protein	24882083
C034557	schizandrer A	schizandrer A results in decreased activity of CYP2E1 protein	25753323
C015499	schizandrin B	schizandrin B results in decreased activity of CYP2E1 protein	25753323
C015499	schizandrin B	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]	31150632
C031409	schizandrin C	schizandrin C results in decreased activity of CYP2E1 protein	25753323
C033585	schizandrol B	schizandrol B binds to CYP2E1 protein	25319358
C033585	schizandrol B	schizandrol B inhibits the reaction [CYP2E1 protein results in increased metabolism of and results in increased activity of Acetaminophen]	25319358
C033585	schizandrol B	schizandrol B results in decreased activity of CYP2E1 protein	25319358
D012643	Selenium	[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP2E1 protein]	21424224
C009237	senecionine	senecionine results in increased expression of CYP2E1 mRNA	26100227
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]	16872732
D000077149	Sevoflurane	CYP2E1 protein results in increased metabolism of Sevoflurane	7879937
C016101	shikonin	shikonin results in decreased activity of CYP2E1 protein	28941798
C461320	shosaiko-to	shosaiko-to results in increased expression of CYP2E1 mRNA	14607025
D012838	Silymarin	Silymarin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]	28797650
D012838	Silymarin	Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]	20964710
D012838	Silymarin	Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	20964710
D012838	Silymarin	Silymarin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2E1 protein]	17410408
D012838	Silymarin	Silymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]	24582681; 29129047;
D012838	Silymarin	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D012838	Silymarin	Silymarin inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D012838	Silymarin	Silymarin inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]	23159886
D012838	Silymarin	Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]	23159886
D012838	Silymarin	Silymarin inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP2E1 protein]	23159886
D012838	Silymarin	Silymarin inhibits the reaction [Paraquat results in increased expression of CYP2E1 mRNA]	23159886
D012862	Skatole	Skatole results in decreased expression of CYP2E1 mRNA	28571685
D012862	Skatole	CYP2E1 protein results in increased hydroxylation of Skatole	30599194
D012862	Skatole	Skatole inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]	30599194
D012862	Skatole	Skatole inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]	30599194
D012906	Smoke	Smoke affects the reaction [Toluene affects the methylation of CYP2E1 promoter]	25963742
D012906	Smoke	Smoke inhibits the reaction [CYP2E1 protein affects the metabolism of Styrene]	16125881
D012906	Smoke	Smoke results in increased expression of CYP2E1 mRNA	23693141
C017947	sodium arsenite	CYP2E1 protein results in decreased susceptibility to sodium arsenite	19154403
C017947	sodium arsenite	sodium arsenite results in decreased expression of CYP2E1 mRNA	29301061
C017947	sodium arsenite	sodium arsenite results in decreased expression of CYP2E1 mRNA	17350061; 17451858;
C017947	sodium arsenite	sodium arsenite results in increased expression of CYP2E1 mRNA	25065748
C017947	sodium arsenite	sodium arsenite results in increased expression of CYP2E1 protein	29044176
C028982	sodium chromate(VI)	Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)]	1903091
C028982	sodium chromate(VI)	CYP2E1 protein results in increased reduction of sodium chromate(VI)	1903091
C028982	sodium chromate(VI)	Carbon Monoxide inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)]	1903091
C028982	sodium chromate(VI)	CYP2E1 protein binds to and results in increased reduction of sodium chromate(VI)	1903091
D012982	Sodium, Dietary	CYP2E1 gene polymorphism affects the susceptibility to Sodium, Dietary	14696128
D053260	Soot	Soot results in increased expression of CYP2E1 mRNA	26551751
C053003	S-phenyl-N-acetylcysteine	[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of S-phenyl-N-acetylcysteine	15051535
D019311	Staurosporine	Staurosporine inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]	11306697
D019311	Staurosporine	Staurosporine results in increased expression of CYP2E1 mRNA	11306697
C031183	stearic acid	stearic acid results in increased activity of CYP2E1 protein	26739624
D013311	Streptozocin	Streptozocin results in decreased expression of CYP2E1 protein	12700423
D013311	Streptozocin	[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased activity of CYP2E1 protein	24815820
D013311	Streptozocin	Streptozocin results in increased expression of CYP2E1 mRNA	11752103; 25905778;
D013311	Streptozocin	Streptozocin results in increased expression of CYP2E1 protein	14693714
D020058	Styrene	CYP2E1 gene polymorphism affects the metabolism of Styrene	12893075; 20117323;
D020058	Styrene	CYP2E1 gene polymorphism affects the susceptibility to Styrene	12604177; 14751678; 20117323;
D020058	Styrene	CYP2E1 gene polymorphism results in decreased metabolism of Styrene	16125881
D020058	Styrene	CYP2E1 gene polymorphism results in increased susceptibility to Styrene	11535253
D020058	Styrene	CYP2E1 protein affects the metabolism of Styrene	12464798
D020058	Styrene	CYP2E1 protein affects the oxidation of Styrene	16872732
D020058	Styrene	CYP2E1 protein results in increased oxidation of Styrene	1664256
D020058	Styrene	CYP2E1 protein results in increased susceptibility to Styrene	16872732
D020058	Styrene	CYP2E1 results in increased metabolism of and results in increased susceptibility to Styrene	22366341
D020058	Styrene	CYP2E1 results in increased metabolism of and results in increased susceptibility to Styrene analog	22366341
D020058	Styrene	[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene	20470765
D020058	Styrene	Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]	16872732
D020058	Styrene	GSTM1 protein affects the reaction [CYP2E1 protein affects the metabolism of Styrene]	12464798
D020058	Styrene	S-ethyl glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]	16872732
D020058	Styrene	Smoke inhibits the reaction [CYP2E1 protein affects the metabolism of Styrene]	16125881
D020058	Styrene	Styrene results in increased expression of CYP2E1 mRNA	21030303
D020058	Styrene	CYP2E1 protein affects the metabolism of Styrene	12746132
D020058	Styrene	CYP2E1 protein results in increased metabolism of Styrene	24320693
D020058	Styrene	CYP2E1 protein results in increased susceptibility to Styrene	15110085
D020058	Styrene	[Ditiocarb co-treated with CYP2E1 gene mutant form] results in decreased metabolism of Styrene	12746132
D020058	Styrene	CYP2E1 protein results in increased oxidation of Styrene	26463279
D020058	Styrene	gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 mRNA]	18202523
D020058	Styrene	gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 protein]	18202523
D020058	Styrene	Styrene results in increased expression of CYP2E1 mRNA	16418063; 18202523;
D020058	Styrene	Styrene results in increased expression of CYP2E1 protein	16418063; 18202523;
C013690	styrene oxide	CYP2E1 results in increased chemical synthesis of styrene oxide	22366341
C013690	styrene oxide	CYP2E1 results in increased chemical synthesis of styrene oxide analog	22366341
D013438	Sulfhydryl Compounds	Sulfhydryl Compounds results in decreased expression of CYP2E1 protein	8117321
C016766	sulforafan	sulforafan inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 mRNA]	21684301
C016766	sulforafan	sulforafan inhibits the reaction [cyanoginosin LR results in increased expression of CYP2E1 protein]	21684301
C016766	sulforafan	sulforafan results in increased expression of CYP2E1 mRNA	30529165
D000077210	Sunitinib	Sunitinib results in increased expression of CYP2E1 mRNA	26797788
D013629	Tamoxifen	Carbon Tetrachloride promotes the reaction [Tamoxifen results in decreased expression of CYP2E1 mRNA]	29974145
D013629	Tamoxifen	Carbon Tetrachloride promotes the reaction [Tamoxifen results in decreased expression of CYP2E1 protein]	29974145
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]	29974145
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]	29974145
D013629	Tamoxifen	Tamoxifen results in decreased activity of CYP2E1 protein	18420780
D013629	Tamoxifen	Tamoxifen results in decreased expression of CYP2E1 mRNA	29974145
D013629	Tamoxifen	Tamoxifen results in decreased expression of CYP2E1 protein	29974145
D013654	Taurine	Taurine inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]	20166895
D013654	Taurine	Taurine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	20067817
D013654	Taurine	Taurine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	20166895
C003377	taxifolin	taxifolin results in decreased expression of CYP2E1 mRNA	17541156
C489139	t-butyl acetylene	cumene hydroperoxide inhibits the reaction [t-butyl acetylene results in decreased activity of CYP2E1 protein mutant form]	15379534
C489139	t-butyl acetylene	cumene hydroperoxide promotes the reaction [t-butyl acetylene results in decreased activity of CYP2E1 protein]	15379534
C489139	t-butyl acetylene	t-butyl acetylene results in decreased activity of CYP2E1 protein	15379534
C489139	t-butyl acetylene	t-butyl acetylene results in decreased activity of CYP2E1 protein mutant form	15379534
C489139	t-butyl acetylene	tert-Butylhydroperoxide promotes the reaction [t-butyl acetylene results in decreased activity of CYP2E1 protein]	15379534
C489139	t-butyl acetylene	tert-Butylhydroperoxide promotes the reaction [t-butyl acetylene results in decreased activity of CYP2E1 protein mutant form]	15379534
D013662	Tea	Tea results in decreased expression of CYP2E1 mRNA	19370779
D013662	Tea	Tea results in decreased expression of CYP2E1 protein	19370779
D013662	Tea	Tea results in increased expression of and results in increased activity of CYP2E1 protein	24815822
C087114	tebuconazole	tebuconazole results in decreased expression of CYP2E1 mRNA	30458266
C087114	tebuconazole	tebuconazole results in increased expression of CYP2E1 protein	29923317
C001803	tempol	tempol inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000068698	Tenofovir	Tenofovir results in decreased activity of CYP2E1 protein	17162464
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide promotes the reaction [t-butyl acetylene results in decreased activity of CYP2E1 protein]	15379534
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide promotes the reaction [t-butyl acetylene results in decreased activity of CYP2E1 protein mutant form]	15379534
D013739	Testosterone	Testosterone results in increased expression of CYP2E1 mRNA	20403060
D013739	Testosterone	Testosterone results in increased expression of CYP2E1 protein	7839370
C041181	tetrachlorodian	tetrachlorodian results in increased expression of CYP2E1 mRNA	31326446
D013749	Tetrachlorodibenzodioxin	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]	28673560
D013749	Tetrachlorodibenzodioxin	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]	28673560
D013749	Tetrachlorodibenzodioxin	ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]	28673560
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP2E1 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Endosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]	28673560
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CYP2E1 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [Endosulfan results in decreased expression of CYP2E1 mRNA]	28673560
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP2E1	27055685
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA	20106945; 21296121; 26159488; 28571685; 28673560;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 protein	28673560
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYP2E1 mRNA	23669205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CYP2E1 mRNA	17949056
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP2E1 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA	19770486; 28213091;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYP2E1 mRNA	16120747
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of CYP2E1 mRNA	21602191
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA	16054898; 18796159; 19692669; 21215274; 31511937;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 protein	31511937
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CYP2E1 mRNA	19969063
D013750	Tetrachloroethylene	CYP2E1 protein results in increased oxidation of Tetrachloroethylene	29897530
D013750	Tetrachloroethylene	[CYP2E1 protein results in increased oxidation of Tetrachloroethylene] which results in increased abundance of Trichloroacetic Acid	29897530
D013750	Tetrachloroethylene	CYP2E1 gene mutant form results in decreased susceptibility to Tetrachloroethylene	29897530
D013750	Tetrachloroethylene	CYP2E1 protein results in increased susceptibility to Tetrachloroethylene	17433522
C009408	tetrachlorophenol	CYP2E1 protein results in increased oxidation of tetrachlorophenol	7747284
D013752	Tetracycline	bicyclol inhibits the reaction [Tetracycline results in decreased expression of CYP2E1 mRNA]	19427351
D013752	Tetracycline	Tetracycline results in decreased expression of CYP2E1 mRNA	19427351
D013755	Tetradecanoylphorbol Acetate	Cycloheximide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	9143349
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [Cycloheximide inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]	8531136
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136; 9143349;
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [CYP2E1 protein results in increased susceptibility to Ethanol]	8798623
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of CYP2E1 protein	8798623
C096277	tetrahydrocurcumin	tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	30423402
C096277	tetrahydrocurcumin	tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]	30423402
D013793	Thallium	CYP2E1 results in increased susceptibility to Thallium	20549620
D013805	Theobromine	4-nitrophenol inhibits the reaction [CYP2E1 protein results in increased metabolism of Theobromine]	10215755
D013805	Theobromine	CYP2E1 protein results in increased chemical synthesis of Theobromine	1302044
D013805	Theobromine	CYP2E1 protein results in increased metabolism of Theobromine	10215755
D013805	Theobromine	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Theobromine]	10215755
D013806	Theophylline	CYP2E1 promoter SNP affects the hydroxylation of Theophylline	16841220
D013806	Theophylline	CYP2E1 protein affects the metabolism of Theophylline	15948934; 16841220;
D013806	Theophylline	CYP2E1 protein results in increased chemical synthesis of Theophylline	1302044
D013806	Theophylline	CYP2E1 protein affects the metabolism of Theophylline	15985363
D013830	Thiadiazoles	Thiadiazoles analog results in decreased activity of CYP2E1 protein	9188722
D013831	Thiamine	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D013831	Thiamine	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
D013844	Thiazoles	[Thiazoles co-treated with ciprofibrate] results in increased expression of CYP2E1 protein	7587954
D013853	Thioacetamide	CYP2E1 protein affects the reaction [Thioacetamide results in decreased expression of GPX1 mRNA]	18374380
D013853	Thioacetamide	CYP2E1 protein affects the reaction [Thioacetamide results in increased expression of IL6 mRNA]	18374380
D013853	Thioacetamide	CYP2E1 protein affects the reaction [Thioacetamide results in increased expression of NOS2 protein]	18374380
D013853	Thioacetamide	CYP2E1 protein affects the reaction [Thioacetamide results in increased expression of TNF mRNA]	18374380
D013853	Thioacetamide	CYP2E1 protein results in increased metabolism of Thioacetamide	29763686
D013853	Thioacetamide	[CYP2E1 protein results in increased metabolism of Thioacetamide] which results in increased chemical synthesis of thioacetamide-S-oxide	29763686
D013853	Thioacetamide	CYP2E1 protein results in increased susceptibility to Thioacetamide	18374380
D013853	Thioacetamide	Thioacetamide results in decreased activity of CYP2E1 protein	29763686
D013853	Thioacetamide	Thioacetamide results in decreased expression of CYP2E1 protein	27349771
D013853	Thioacetamide	Thioacetamide results in increased expression of CYP2E1 protein	30625377
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP2E1 mRNA	28943392
D013853	Thioacetamide	Eugenol inhibits the reaction [Thioacetamide results in increased expression of CYP2E1 protein]	20036707
D013853	Thioacetamide	Thioacetamide results in decreased expression of CYP2E1 mRNA	16297948
D013853	Thioacetamide	Thioacetamide results in increased expression of CYP2E1 protein	20036707
C029188	thioacetamide-S-oxide	[CYP2E1 protein results in increased metabolism of Thioacetamide] which results in increased chemical synthesis of thioacetamide-S-oxide	29763686
D013859	Thiocarbamates	Thiocarbamates analog results in decreased activity of CYP2E1 protein	29984871
D013875	Thiophanate	Thiophanate results in increased expression of CYP2E1 protein	10096430
D013881	Thioridazine	Thioridazine results in decreased activity of CYP2E1 protein	15135088
D013883	Thiostrepton	Thiostrepton results in decreased expression of CYP2E1 mRNA	22321511
D013893	Thiram	CYP2E1 protein results in increased metabolism of Thiram	12458634
D013893	Thiram	Thiram inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]	12458634
D008625	Tiopronin	Tiopronin inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]	19683030
D000077704	Tirapazamine	1-phenylimidazole inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000077704	Tirapazamine	2-Propanol inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000077704	Tirapazamine	caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000077704	Tirapazamine	CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000077704	Tirapazamine	CYP2E1 protein results in increased reduction of and results in increased activity of and results in increased susceptibility to Tirapazamine	7710944
D000077704	Tirapazamine	Deferoxamine inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000077704	Tirapazamine	Dicumarol promotes the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000077704	Tirapazamine	Ethanol inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000077704	Tirapazamine	Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000077704	Tirapazamine	purpurogallin inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000077704	Tirapazamine	Quercetin inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
D000077704	Tirapazamine	tempol inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]	7710944
C009495	titanium dioxide	titanium dioxide results in increased expression of CYP2E1 mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in decreased expression of CYP2E1 mRNA	30012374
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CYP2E1 mRNA	29505817
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CYP2E1 mRNA	29501877
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CYP2E1 mRNA	30610935
D014028	Tobacco Smoke Pollution	[Dietary Fats co-treated with Tobacco Smoke Pollution] results in increased activity of CYP2E1 protein	29688711
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased activity of CYP2E1 protein	29688711
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CYP2E1 mRNA	23038017
D014050	Toluene	CYP2E1 protein affects the metabolism of Toluene	8592870
D014050	Toluene	Ditiocarb inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene]	8592870
D014050	Toluene	Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene]	8592870
D014050	Toluene	CYP2E1 gene polymorphism affects the susceptibility to Toluene	17292523
D014050	Toluene	CYP2E1 protein alternative form results in increased metabolism of Toluene	20033806
D014050	Toluene	CYP2E1 protein results in increased metabolism of Toluene	12464242; 18350910; 20033806; 8558417;
D014050	Toluene	Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Toluene]	8558417
D014050	Toluene	Smoke affects the reaction [Toluene affects the methylation of CYP2E1 promoter]	25963742
D014050	Toluene	Toluene affects the activity of CYP2E1 protein	25963742
D014050	Toluene	Toluene affects the methylation of CYP2E1 promoter	25963742
D014050	Toluene	Toluene results in increased expression of CYP2E1 mRNA	16581535; 25963742; 30910524;
D014050	Toluene	CYP2E1 protein results in increased metabolism of Toluene	8461037
D014050	Toluene	[Toluene co-treated with Benzene] results in increased activity of CYP2E1 protein	18455711
D014050	Toluene	Acetone promotes the reaction [Toluene results in increased expression of CYP2E1 protein]	8996725
D014050	Toluene	[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Toluene	9010585
D014050	Toluene	CYP2E1 protein affects the metabolism of Toluene	8620572
D014050	Toluene	CYP2E1 protein affects the reaction [Benzene results in increased metabolism of Toluene]	8620572
D014050	Toluene	CYP2E1 protein affects the reaction [Toluene results in increased metabolism of Toluene]	8620572
D014050	Toluene	CYP2E1 protein affects the reaction [Trichloroethylene results in increased metabolism of Toluene]	8620572
D014050	Toluene	CYP2E1 protein results in increased oxidation of Toluene	1994898
D014050	Toluene	Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of Toluene]	1994898
D014050	Toluene	Methylcholanthrene promotes the reaction [CYP2E1 protein results in increased oxidation of Toluene]	1994898
D014050	Toluene	Toluene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]	8889796
D014050	Toluene	Toluene results in increased activity of CYP2E1 protein	12919724; 8620572; 8889796;
D014050	Toluene	Toluene results in increased expression of CYP2E1 mRNA	12919724
D014050	Toluene	Toluene results in increased expression of CYP2E1 protein	12919724; 8517779; 8620572; 8996725;
D014050	Toluene	Disulfiram inhibits the reaction [Toluene results in increased activity of CYP2E1 protein]	12781212
D014050	Toluene	Toluene results in increased activity of CYP2E1 protein	12781212
D014107	Tosyllysine Chloromethyl Ketone	Tosyllysine Chloromethyl Ketone inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]	9143349
D000077606	Trabectedin	Trabectedin results in decreased activity of CYP2E1 protein	12154027
C507866	trans-1,2-dihydro-1,2-naphthalenediol	CYP2E1 protein results in increased abundance of trans-1,2-dihydro-1,2-naphthalenediol	16243959
C560613	transfluthrin	transfluthrin results in increased expression of and results in increased activity of CYP2E1 protein	22080754
D014191	Tranylcypromine	Tranylcypromine results in decreased activity of CYP2E1 protein	15155557
D014212	Tretinoin	Tretinoin promotes the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]	8531136
D014212	Tretinoin	Tretinoin results in increased expression of CYP2E1 mRNA	24977338
D014212	Tretinoin	CYP2E1 protein results in increased metabolism of Tretinoin	16054987
D014212	Tretinoin	Ethanol promotes the reaction [CYP2E1 protein results in increased metabolism of Tretinoin]	16054987
C032910	triadimefon	triadimefon results in decreased expression of CYP2E1 mRNA	16730040
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	19325051
C447082	tricarbonyldichlororuthenium (II) dimer	zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]]	19325051
D014238	Trichloroacetic Acid	[CYP2E1 protein results in increased oxidation of Tetrachloroethylene] which results in increased abundance of Trichloroacetic Acid	29897530
D014238	Trichloroacetic Acid	[CYP2E1 protein results in increased oxidation of Trichloroethylene] which results in increased abundance of Trichloroacetic Acid	29897530
D014241	Trichloroethylene	CYP2E1 gene polymorphism results in increased susceptibility to Trichloroethylene	19351467
D014241	Trichloroethylene	CYP2E1 protein affects the metabolism of Trichloroethylene	17710613
D014241	Trichloroethylene	CYP2E1 protein results in increased metabolism of Trichloroethylene	10841534; 18350910;
D014241	Trichloroethylene	CYP2E1 protein results in increased oxidation of Trichloroethylene	1664256; 29897530;
D014241	Trichloroethylene	[CYP2E1 protein results in increased oxidation of Trichloroethylene] which results in increased abundance of Trichloroacetic Acid	29897530
D014241	Trichloroethylene	Trichloroethylene results in increased activity of CYP2E1 protein	17710613
D014241	Trichloroethylene	CYP2E1 protein results in increased metabolism of Trichloroethylene	10774820; 18565563; 8461037;
D014241	Trichloroethylene	[diallyl disulfide results in decreased expression of CYP2E1 protein] which results in decreased metabolism of and results in decreased susceptibility to Trichloroethylene	10774820
D014241	Trichloroethylene	Trichloroethylene results in increased expression of CYP2E1 protein	10753203
D014241	Trichloroethylene	1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Trichloroethylene]	7871537
D014241	Trichloroethylene	CYP2E1 protein affects the metabolism of Trichloroethylene	17710613; 7871537;
D014241	Trichloroethylene	CYP2E1 protein affects the reaction [Trichloroethylene results in increased metabolism of Toluene]	8620572
D014241	Trichloroethylene	CYP2E1 protein results in increased metabolism of Trichloroethylene	1739413; 18249509; 8461037;
D014241	Trichloroethylene	[CYP2E1 protein results in increased metabolism of Trichloroethylene] which results in increased chemical synthesis of Chloral Hydrate	1739413
D014241	Trichloroethylene	CYP2E1 protein results in increased susceptibility to Trichloroethylene	17433522
D014241	Trichloroethylene	Trichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]	9851676
D014241	Trichloroethylene	Trichloroethylene results in increased activity of CYP2E1 protein	17710613; 8620572;
D014241	Trichloroethylene	Trichloroethylene results in increased expression of CYP2E1 protein	8620572
C025280	trichloromethyl free radical	[CYP2E1 protein results in increased metabolism of Carbon Tetrachloride] which results in increased abundance of trichloromethyl free radical	19336974
D022882	Trihalomethanes	CYP2E1 gene SNP results in increased susceptibility to Trihalomethanes	15289170
D022882	Trihalomethanes	CYP2E1 polymorphism affects the susceptibility to Trihalomethanes	20675267
D022882	Trihalomethanes	CYP2E1 protein results in increased metabolism of Trihalomethanes	24647036
D014284	Triiodothyronine	Triiodothyronine results in increased activity of CYP2E1 protein	14631868
D014284	Triiodothyronine	Triiodothyronine results in increased expression of CYP2E1 protein	14631868
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP2E1 protein	18079364
D000077288	Troglitazone	Troglitazone results in increased expression of CYP2E1 mRNA	28973697
D000077288	Troglitazone	Troglitazone results in increased expression of CYP2E1 mRNA	21515302
D014363	Tryptamines	Tryptamines analog results in decreased activity of CYP2E1 protein	26599973
D014363	Tryptamines	[Tryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone	26599973
C012596	turmeric extract	turmeric extract affects the reaction [Cisplatin results in decreased activity of CYP2E1 protein]	24882083
C012596	turmeric extract	turmeric extract affects the reaction [Paclitaxel results in decreased activity of CYP2E1 protein]	24882083
C113580	U 0126	U 0126 inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]	28385499
C113580	U 0126	U 0126 inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	28385499
C025699	U 40481	U 40481 results in increased expression of CYP2E1 protein	31029719
D014501	Uranium	[Acetaminophen co-treated with Uranium analog] results in decreased expression of CYP2E1 mRNA	17126469
D014501	Uranium	Uranium analog promotes the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]	17126469
D014520	Urethane	CYP2E1 protein results in increased oxidation of Urethane	1664256
D014520	Urethane	1-aminobenzotriazole inhibits the reaction [CYP2E1 protein affects the metabolism of Urethane]	12704224
D014520	Urethane	CYP2E1 gene mutant form inhibits the reaction [Urethane affects the expression of MKI67 protein]	15790490
D014520	Urethane	CYP2E1 gene mutant form results in decreased metabolism of Urethane	12704224
D014520	Urethane	CYP2E1 gene mutant form results in decreased susceptibility to Urethane	17093202
D014520	Urethane	CYP2E1 protein affects the hydroxylation of Urethane	15879495
D014520	Urethane	CYP2E1 protein affects the metabolism of Urethane	12704224; 15879495; 17979661;
D014520	Urethane	CYP2E1 protein affects the oxidation of Urethane	20205516
D014520	Urethane	CYP2E1 protein results in increased susceptibility to Urethane	15790490
D014520	Urethane	[Urethane co-treated with Ethanol] results in increased activity of CYP2E1 protein	15582191
D014520	Urethane	CYP2E1 affects the oxidation of Urethane	17341656
D014520	Urethane	CYP2E1 protein affects the oxidation of Urethane	17093202
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of and results in decreased activity of CYP2E1 protein]	10453939
C073339	usnic acid	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP2E1 mRNA	22777745
C073339	usnic acid	usnic acid results in decreased expression of CYP2E1 mRNA	21953288; 22777745;
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYP2E1 mRNA	29154799; 29501571;
D014635	Valproic Acid	Valproic Acid results in decreased expression of CYP2E1 mRNA	17381134
D014640	Vancomycin	[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2E1 mRNA	30545405
C043425	vanoxerine	[Chlorzoxazone results in decreased activity of CYP2E1 protein] which results in decreased degradation of vanoxerine	11502731
C043425	vanoxerine	CYP2E1 protein results in decreased degradation of vanoxerine	11502731
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CYP2E1 mRNA	22352393; 24216475;
C025643	vinclozolin	[acephate co-treated with vinclozolin] affects the expression of CYP2E1 protein	17686559
C025643	vinclozolin	[fenarimol co-treated with vinclozolin] affects the expression of CYP2E1 protein	17686559
C025643	vinclozolin	[fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2E1 protein	17686559
C025643	vinclozolin	vinclozolin affects the expression of CYP2E1 mRNA	8921505
C025643	vinclozolin	vinclozolin affects the expression of CYP2E1 protein	8921505
C025643	vinclozolin	vinclozolin results in increased expression of CYP2E1 protein	25929820
C003763	vinyl bromide	CYP2E1 protein results in increased oxidation of vinyl bromide	1664256
C017963	vinyl carbamate	CYP2E1 protein affects the metabolism of vinyl carbamate	11181492
C017963	vinyl carbamate	CYP2E1 protein results in increased oxidation of vinyl carbamate	1664256
C017963	vinyl carbamate	[vinyl carbamate co-treated with NADP] inhibits the reaction [CYP2E1 protein results in decreased methylation of Dimethylnitrosamine]	11181492
C017963	vinyl carbamate	CYP2E1 protein affects the oxidation of vinyl carbamate	20205516
C017963	vinyl carbamate	diallyl sulfone inhibits the reaction [CYP2E1 protein affects the oxidation of vinyl carbamate]	17341656
C017963	vinyl carbamate	[diallyl sulfone results in decreased activity of CYP2E1 protein] which affects the susceptibility to vinyl carbamate	20205516
C017963	vinyl carbamate	vinyl carbamate results in decreased activity of CYP2E1 protein	11134547
C017963	vinyl carbamate	vinyl carbamate results in decreased expression of CYP2E1 protein	11134547
C017963	vinyl carbamate	CYP2E1 protein affects the oxidation of vinyl carbamate	17296623
C017963	vinyl carbamate	diallyl sulfone inhibits the reaction [CYP2E1 protein affects the oxidation of vinyl carbamate]	17296623
C017963	vinyl carbamate	CYP2E1 affects the oxidation of vinyl carbamate	17341656
D014752	Vinyl Chloride	CYP2E1 gene polymorphism affects the susceptibility to Vinyl Chloride	20134343
D014752	Vinyl Chloride	CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of KRAS gene]	12705718
D014752	Vinyl Chloride	CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]	12705718
D014752	Vinyl Chloride	CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of KRAS gene]	17384900
D014752	Vinyl Chloride	CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of TP53 gene]	12010862; 17384900;
D014752	Vinyl Chloride	CYP2E1 gene polymorphism results in increased susceptibility to Vinyl Chloride	16270392
D014752	Vinyl Chloride	CYP2E1 gene SNP results in increased susceptibility to Vinyl Chloride	18420361; 20100738;
D014752	Vinyl Chloride	CYP2E1 protein affects the metabolism of Vinyl Chloride	17710613
D014752	Vinyl Chloride	CYP2E1 protein results in increased metabolism of Vinyl Chloride	18350910
D014752	Vinyl Chloride	CYP2E1 protein results in increased oxidation of Vinyl Chloride	1664256
D014752	Vinyl Chloride	Vinyl Chloride results in increased activity of CYP2E1 protein	17710613
D014752	Vinyl Chloride	1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Vinyl Chloride]	7871537
D014752	Vinyl Chloride	CYP2E1 protein affects the metabolism of Vinyl Chloride	17710613; 7871537;
D014752	Vinyl Chloride	Vinyl Chloride results in increased activity of CYP2E1 protein	15211785; 17710613;
D014752	Vinyl Chloride	CYP2E1 protein affects the metabolism of Vinyl Chloride	18420361
D014752	Vinyl Chloride	CYP2E1 protein results in increased metabolism of Vinyl Chloride	26962056
D014752	Vinyl Chloride	[CYP2E1 protein results in increased metabolism of Vinyl Chloride] which results in increased abundance of Ethylene Chlorohydrin	26962056
C016829	vinyl fluoride	[Fomepizole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of vinyl fluoride	9073601
C016829	vinyl fluoride	CYP2E1 protein affects the oxidation of vinyl fluoride	9073601
C016829	vinyl fluoride	[Fomepizole results in decreased activity of CYP2E1 protein] which results in decreased uptake of vinyl fluoride	9073601
C016829	vinyl fluoride	[Ethanol results in increased activity of CYP2E1 protein] which results in increased metabolism of vinyl fluoride	9073601
C029297	vinylidene chloride	CYP2E1 protein results in increased metabolism of vinylidene chloride	10215634; 15319346;
C029297	vinylidene chloride	diallyl sulfone inhibits the reaction [CYP2E1 protein results in increased metabolism of vinylidene chloride]	10215634
C029297	vinylidene chloride	CYP2E1 protein results in increased metabolism of vinylidene chloride	11356946; 15319346;
C029297	vinylidene chloride	vinylidene chloride results in increased expression of CYP2E1 protein	26682919
C029297	vinylidene chloride	CYP2E1 protein results in increased metabolism of vinylidene chloride	15319346
D014800	Vitallium	Vitallium analog results in decreased expression of CYP2E1 mRNA	23825117
D014801	Vitamin A	CYP2E1 protein results in increased metabolism of Vitamin A	16054987
D014801	Vitamin A	Ethanol promotes the reaction [CYP2E1 protein results in increased metabolism of Vitamin A]	16054987
D014805	Vitamin B 12	[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	20118189
D014810	Vitamin E	Vitamin E inhibits the reaction [CYP2E1 protein results in increased expression of COL1A2 mRNA]	10498651
D014810	Vitamin E	Vitamin E inhibits the reaction [decamethrin results in increased expression of CYP2E1 mRNA]	25439240
D024483	Vitamin K 3	Vitamin K 3 results in decreased expression of CYP2E1 mRNA	25270620
C574123	walrycin A	walrycin A results in increased expression of CYP2E1 mRNA	22314385
D000077191	Wortmannin	Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]	11306697
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CYP2E1 mRNA	27935865
C098009	YH 439	YH 439 inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of CYP2E1 protein]	11562448
C098009	YH 439	YH 439 results in decreased expression of and results in decreased activity of CYP2E1 protein	11562448
C098009	YH 439	YH 439 results in decreased expression of CYP2E1 mRNA	11562448
D015025	Zearalenone	Zearalenone results in increased expression of CYP2E1 mRNA	20607812
D015032	Zinc	[Zinc deficiency co-treated with Ethanol] results in increased expression of CYP2E1 protein	24155903
D015032	Zinc	Zinc deficiency results in increased expression of CYP2E1 protein	24155903
D015032	Zinc	[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP2E1 protein]	21424224
D015032	Zinc	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]	27919644
D015032	Zinc	[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]	27919644
C017803	zinc protoporphyrin	zinc protoporphyrin inhibits the reaction [Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]]	19325051
C017803	zinc protoporphyrin	zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]]	19325051
C017803	zinc protoporphyrin	[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 mRNA	26747958
C017803	zinc protoporphyrin	[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 protein	26747958
C017803	zinc protoporphyrin	zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]	26747958
C017803	zinc protoporphyrin	zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]	26747958
D019287	Zinc Sulfate	CYP2E1 results in increased susceptibility to [Arachidonic Acid co-treated with Zinc Sulfate]	12566070
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Arachidonic Acid]	12566070
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Buthionine Sulfoximine]	12566070
D019287	Zinc Sulfate	[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	20118189
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	15920153
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	15920153
D019287	Zinc Sulfate	Paraquat promotes the reaction [Zinc Sulfate results in increased expression of CYP2E1 mRNA]	20553223
D019287	Zinc Sulfate	Zinc Sulfate promotes the reaction [Paraquat results in increased expression of CYP2E1 mRNA]	20553223
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of CYP2E1 mRNA	20553223
C013738	zingerone	zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CYP2E1 protein]	30720227
C013738	zingerone	zingerone inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]	28442378
D015049	Zoxazolamine	CYP2E1 protein results in increased metabolism of and results in decreased activity of Zoxazolamine	16109766

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0903	Direct protein sequencing
KW-0256	Endoplasmic reticulum
KW-0276	Fatty acid metabolism
KW-0349	Heme
KW-0408	Iron
KW-0443	Lipid metabolism
KW-0472	Membrane
KW-0479	Metal-binding
KW-0492	Microsome
KW-0496	Mitochondrion
KW-0999	Mitochondrion inner membrane
KW-0503	Monooxygenase
KW-0521	NADP
KW-0560	Oxidoreductase
KW-0621	Polymorphism
KW-1185	Reference proteome

Interpro

InterPro ID	InterPro Term
IPR001128	Cyt_P450
IPR017972	Cyt_P450_CS
IPR002401	Cyt_P450_E_grp-I
IPR008070	Cyt_P450_E_grp-I_CYP2E-like
IPR036396	Cyt_P450_sf

PROSITE

PROSITE ID	PROSITE Term
PS00086	CYTOCHROME_P450

Pfam

Pfam ID	Pfam Term
PF00067	p450

Gene: CYP2E1

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction