| Tag | Content |
|---|---|
| Uniprot ID | P05305; Q96DA1; |
| Entrez ID | 1906 |
| Genbank protein ID | AAA52407.1; AAB25760.1; AAA52338.1; AAA52339.1; CAA68718.1; AAQ96600.1; AAH09720.1; |
| Genbank nucleotide ID | NM_001955.4; XM_011514330.2; XM_017010331.1; XM_011514331.2; NM_001168319.1; |
| Ensembl protein ID | ENSP00000368683 |
| Ensembl nucleotide ID | ENSG00000078401 |
| Gene name | Endothelin-1 |
| Gene symbol | EDN1 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). |
| Sequence | MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS KRCSCSSLMD 60 KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT KATDRENRCQ CASQKDKKCW 120 NFCQAGKELR AEDIMEKDWN NHKKGKDCSK LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE 180 TMRNSVKSSF HDPKLKGKPS RERYVTHNRA HW 212 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.