CleftGeneDB-Search

Gene: EDN1

Basic information

Tag	Content
Uniprot ID	P05305; Q96DA1;
Entrez ID	1906
Genbank protein ID	AAA52407.1; AAB25760.1; AAA52338.1; AAA52339.1; CAA68718.1; AAQ96600.1; AAH09720.1;
Genbank nucleotide ID	NM_001955.4; XM_011514330.2; XM_017010331.1; XM_011514331.2; NM_001168319.1;
Ensembl protein ID	ENSP00000368683
Ensembl nucleotide ID	ENSG00000078401
Gene name	Endothelin-1
Gene symbol	EDN1
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031).
Sequence	MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS KRCSCSSLMD 60 KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT KATDRENRCQ CASQKDKKCW 120 NFCQAGKELR AEDIMEKDWN NHKKGKDCSK LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE 180 TMRNSVKSSF HDPKLKGKPS RERYVTHNRA HW 212

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1EDN
1EDP
1T7H
1V6R
5GLH
6DK5
1EDN

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	EDN1	281137	P17322		Bos taurus	Prediction	More>>
1:1 ortholog	EDN1	403424	P13206		Canis lupus familiaris	Prediction	More>>
1:1 ortholog	EDN1	102175912	A0A452E9X3		Capra hircus	Prediction	More>>
1:1 ortholog	EDN1	100034060	F7APB1		Equus caballus	Prediction	More>>
1:1 ortholog	EDN1	1906	P05305		Homo sapiens	Prediction	More>>
1:1 ortholog	Edn1	13614	P22387	CPO	Mus musculus	Publication	More>>
1:1 ortholog	EDN1	462437	H2QSB1		Pan troglodytes	Prediction	More>>
1:1 ortholog	EDN1		A0A287AHA8		Sus scrofa	Prediction	More>>
1:1 ortholog	EDN1	100009270	P29560		Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Edn1	24323	P22388		Rattus norvegicus	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs201943749	p.Asp2His	missense variant	-	NC_000006.12:g.12290633G>C	ExAC,gnomAD
COSM4923444	p.Leu4Trp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12290640T>G	NCI-TCGA Cosmic
rs1459410291	p.Ser9Cys	missense variant	-	NC_000006.12:g.12290655C>G	TOPMed,gnomAD
rs73722760	p.Cys15Phe	missense variant	-	NC_000006.12:g.12290673G>T	ExAC,TOPMed,gnomAD
rs73722760	p.Cys15Ser	missense variant	-	NC_000006.12:g.12290673G>C	ExAC,TOPMed,gnomAD
rs751638434	p.Cys15Trp	missense variant	-	NC_000006.12:g.12290674C>G	ExAC,gnomAD
rs750687688	p.Gln16Leu	missense variant	-	NC_000006.12:g.12290676A>T	ExAC,gnomAD
rs377019316	p.Gln16Lys	missense variant	-	NC_000006.12:g.12290675C>A	ESP,ExAC,TOPMed,gnomAD
rs750687688	p.Gln16Pro	missense variant	-	NC_000006.12:g.12290676A>C	ExAC,gnomAD
rs755489890	p.Gly17Glu	missense variant	-	NC_000006.12:g.12290679G>A	ExAC,TOPMed,gnomAD
rs780635071	p.Gly17Arg	missense variant	-	NC_000006.12:g.12290678G>A	ExAC
rs780635071	p.Gly17Ter	stop gained	-	NC_000006.12:g.12290678G>T	ExAC
rs777308856	p.Ala18Ser	missense variant	-	NC_000006.12:g.12290681G>T	ExAC,TOPMed,gnomAD
rs746459355	p.Ala18Gly	missense variant	-	NC_000006.12:g.12290682C>G	ExAC
rs777308856	p.Ala18Thr	missense variant	-	NC_000006.12:g.12290681G>A	ExAC,TOPMed,gnomAD
rs770493724	p.Pro19Gln	missense variant	-	NC_000006.12:g.12290685C>A	ExAC,TOPMed
rs770493724	p.Pro19Leu	missense variant	-	NC_000006.12:g.12290685C>T	ExAC,TOPMed
rs533813384	p.Ala22Glu	missense variant	-	NC_000006.12:g.12292341C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs780775953	p.Val23Ile	missense variant	-	NC_000006.12:g.12292343G>A	TOPMed,gnomAD
rs1367007262	p.Ala26Ser	missense variant	-	NC_000006.12:g.12292352G>T	TOPMed,gnomAD
rs1367007262	p.Ala26Thr	missense variant	-	NC_000006.12:g.12292352G>A	TOPMed,gnomAD
rs1367007262	p.Ala26Thr	missense variant	-	NC_000006.12:g.12292352G>A	NCI-TCGA
rs553767245	p.Glu27Lys	missense variant	-	NC_000006.12:g.12292355G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs754109007	p.Leu28Ile	missense variant	-	NC_000006.12:g.12292358C>A	NCI-TCGA
rs754109007	p.Leu28Ile	missense variant	-	NC_000006.12:g.12292358C>A	ExAC,gnomAD
rs759759347	p.Ser29Arg	missense variant	-	NC_000006.12:g.12292363C>G	ExAC,gnomAD
rs202087445	p.Ala30Val	missense variant	-	NC_000006.12:g.12292365C>T	ESP,ExAC,TOPMed,gnomAD
rs202087445	p.Ala30Glu	missense variant	-	NC_000006.12:g.12292365C>A	ESP,ExAC,TOPMed,gnomAD
rs1479572510	p.Ala30Thr	missense variant	-	NC_000006.12:g.12292364G>A	gnomAD
rs202087445	p.Ala30Val	missense variant	-	NC_000006.12:g.12292365C>T	NCI-TCGA
rs749973432	p.Gly32Ser	missense variant	-	NC_000006.12:g.12292370G>A	ExAC,gnomAD
rs1474510268	p.Glu33Gly	missense variant	-	NC_000006.12:g.12292374A>G	TOPMed
rs1263267835	p.Asn34Lys	missense variant	-	NC_000006.12:g.12292378C>A	gnomAD
rs755650656	p.Gly35Arg	missense variant	-	NC_000006.12:g.12292379G>C	ExAC,TOPMed,gnomAD
rs755650656	p.Gly35Ser	missense variant	-	NC_000006.12:g.12292379G>A	ExAC,TOPMed,gnomAD
rs183694577	p.Gly36Arg	missense variant	-	NC_000006.12:g.12292382G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs183694577	p.Gly36Arg	missense variant	-	NC_000006.12:g.12292382G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs778827439	p.Glu37Gly	missense variant	-	NC_000006.12:g.12292386A>G	ExAC,gnomAD
rs748015875	p.Lys38Glu	missense variant	-	NC_000006.12:g.12292388A>G	ExAC,gnomAD
rs772178393	p.Pro39Thr	missense variant	-	NC_000006.12:g.12292391C>A	ExAC,gnomAD
rs1490793727	p.Thr40Ala	missense variant	-	NC_000006.12:g.12292394A>G	TOPMed
rs149399492	p.Thr40Asn	missense variant	-	NC_000006.12:g.12292395C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs149399492	p.Thr40Ile	missense variant	-	NC_000006.12:g.12292395C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs149399492	p.Thr40Ser	missense variant	-	NC_000006.12:g.12292395C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1299418415	p.Pro41His	missense variant	-	NC_000006.12:g.12292398C>A	gnomAD
rs144801601	p.Pro41Ser	missense variant	-	NC_000006.12:g.12292397C>T	ESP,TOPMed
rs576313237	p.Ser42Cys	missense variant	-	NC_000006.12:g.12292400A>T	1000Genomes,ExAC,gnomAD
rs576313237	p.Ser42Arg	missense variant	-	NC_000006.12:g.12292400A>C	1000Genomes,ExAC,gnomAD
COSM3857974	p.Ser42Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12292400A>G	NCI-TCGA Cosmic
rs370873027	p.Pro44Ser	missense variant	-	NC_000006.12:g.12292406C>T	ESP,ExAC,TOPMed,gnomAD
rs1193581265	p.Pro44Leu	missense variant	-	NC_000006.12:g.12292407C>T	TOPMed
rs1383893344	p.Arg46Pro	missense variant	-	NC_000006.12:g.12292413G>C	TOPMed,gnomAD
rs200759992	p.Arg46Trp	missense variant	-	NC_000006.12:g.12292412C>T	ESP,ExAC,TOPMed,gnomAD
rs368802545	p.Arg48Leu	missense variant	-	NC_000006.12:g.12292419G>T	ESP,ExAC,gnomAD
rs368802545	p.Arg48His	missense variant	-	NC_000006.12:g.12292419G>A	ESP,ExAC,gnomAD
rs1239711154	p.Arg48Cys	missense variant	-	NC_000006.12:g.12292418C>T	gnomAD
rs372723252	p.Ser50Phe	missense variant	-	NC_000006.12:g.12292425C>T	ESP,ExAC,gnomAD
rs1284924294	p.Ser54Pro	missense variant	-	NC_000006.12:g.12292436T>C	gnomAD
rs573471977	p.Ser56Trp	missense variant	-	NC_000006.12:g.12292443C>G	TOPMed,gnomAD
rs573471977	p.Ser56Ter	stop gained	-	NC_000006.12:g.12292443C>A	TOPMed,gnomAD
rs754711482	p.Leu58Met	missense variant	-	NC_000006.12:g.12292448C>A	ExAC,gnomAD
RCV000723296	p.Glu62Gln	missense variant	Question mark ears, isolated (QME)	NC_000006.12:g.12292460G>C	ClinVar
rs1064796796	p.Cys63Tyr	missense variant	-	NC_000006.12:g.12292464G>A	-
RCV000483261	p.Cys63Tyr	missense variant	-	NC_000006.12:g.12292464G>A	ClinVar
RCV000106314	p.Val64Asp	missense variant	Question mark ears, isolated (QME)	NC_000006.12:g.12292467T>A	ClinVar
rs587777233	p.Val64Asp	missense variant	-	NC_000006.12:g.12292467T>A	-
rs587777233	p.Val64Asp	missense variant	Question mark ears, isolated (QME)	NC_000006.12:g.12292467T>A	UniProt,dbSNP
VAR_071152	p.Val64Asp	missense variant	Question mark ears, isolated (QME)	NC_000006.12:g.12292467T>A	UniProt
NCI-TCGA novel	p.Tyr65LeuPheSerTerUnkUnk	frameshift	-	NC_000006.12:g.12292467_12292468TC>-	NCI-TCGA
COSM3620075	p.Tyr65Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12292470A>G	NCI-TCGA Cosmic
rs777792460	p.Ile71Val	missense variant	-	NC_000006.12:g.12292487A>G	ExAC,gnomAD
NCI-TCGA novel	p.Trp73Ter	stop gained	-	NC_000006.12:g.12292495G>A	NCI-TCGA
NCI-TCGA novel	p.Val74Gly	missense variant	-	NC_000006.12:g.12292497T>G	NCI-TCGA
rs565425223	p.Asn75Lys	missense variant	-	NC_000006.12:g.12292501C>G	1000Genomes,ExAC,gnomAD
rs746943183	p.Asn75Ser	missense variant	-	NC_000006.12:g.12292500A>G	ExAC,gnomAD
rs912386275	p.Asn75Tyr	missense variant	-	NC_000006.12:g.12292499A>T	TOPMed
rs776827646	p.Thr76Asn	missense variant	-	NC_000006.12:g.12292503C>A	ExAC,gnomAD
rs587777232	p.Pro77His	missense variant	-	NC_000006.12:g.12292506C>A	-
rs587777232	p.Pro77His	missense variant	Auriculocondylar syndrome 3 (ARCND3)	NC_000006.12:g.12292506C>A	UniProt,dbSNP
VAR_071153	p.Pro77His	missense variant	Auriculocondylar syndrome 3 (ARCND3)	NC_000006.12:g.12292506C>A	UniProt
RCV000106313	p.Pro77His	missense variant	Auriculocondylar syndrome 3 (ARCND3)	NC_000006.12:g.12292506C>A	ClinVar
rs1446318735	p.Glu78Gln	missense variant	-	NC_000006.12:g.12292508G>C	gnomAD
rs770093045	p.Glu78Gly	missense variant	-	NC_000006.12:g.12292509A>G	ExAC,gnomAD
rs774749384	p.His79Tyr	missense variant	-	NC_000006.12:g.12293942C>T	ExAC,gnomAD
rs144271441	p.His79Arg	missense variant	-	NC_000006.12:g.12293943A>G	ESP
rs147381256	p.Val80Ile	missense variant	-	NC_000006.12:g.12293945G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1191532177	p.Val80Asp	missense variant	-	NC_000006.12:g.12293946T>A	gnomAD
rs139407538	p.Pro82Leu	missense variant	-	NC_000006.12:g.12293952C>T	ESP,ExAC,TOPMed,gnomAD
rs587777234	p.Tyr83Ter	stop gained	-	NC_000006.12:g.12293956T>G	-
RCV000106315	p.Tyr83Ter	nonsense	Question mark ears, isolated (QME)	NC_000006.12:g.12293956T>G	ClinVar
COSM3620076	p.Gly84Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12293957G>A	NCI-TCGA Cosmic
COSM3920664	p.Gly86Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12293964G>A	NCI-TCGA Cosmic
rs1401223395	p.Pro88Ser	missense variant	-	NC_000006.12:g.12293969C>T	gnomAD
rs752388910	p.Arg89Lys	missense variant	-	NC_000006.12:g.12293973G>A	ExAC,gnomAD
rs762749838	p.Ser90Tyr	missense variant	-	NC_000006.12:g.12293976C>A	ExAC,gnomAD
RCV000106312	p.Lys91Glu	missense variant	Auriculocondylar syndrome 3 (ARCND3)	NC_000006.12:g.12293978A>G	ClinVar
rs587777231	p.Lys91Glu	missense variant	-	NC_000006.12:g.12293978A>G	-
rs587777231	p.Lys91Glu	missense variant	Auriculocondylar syndrome 3 (ARCND3)	NC_000006.12:g.12293978A>G	UniProt,dbSNP
VAR_071154	p.Lys91Glu	missense variant	Auriculocondylar syndrome 3 (ARCND3)	NC_000006.12:g.12293978A>G	UniProt
NCI-TCGA novel	p.Ala93Ser	missense variant	-	NC_000006.12:g.12293984G>T	NCI-TCGA
rs763955920	p.Ala93Thr	missense variant	-	NC_000006.12:g.12293984G>A	ExAC,TOPMed,gnomAD
COSM1072808	p.Ala93Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12293985C>T	NCI-TCGA Cosmic
rs751438470	p.Glu95Gln	missense variant	-	NC_000006.12:g.12293990G>C	ExAC,TOPMed,gnomAD
rs751438470	p.Glu95Lys	missense variant	-	NC_000006.12:g.12293990G>A	ExAC,TOPMed,gnomAD
COSM1072809	p.Glu95Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12293992G>T	NCI-TCGA Cosmic
rs757031803	p.Leu98His	missense variant	-	NC_000006.12:g.12294000T>A	ExAC,gnomAD
rs1273930303	p.Ala102Thr	missense variant	-	NC_000006.12:g.12294011G>A	gnomAD
rs750339407	p.Thr103Ala	missense variant	-	NC_000006.12:g.12294014A>G	ExAC,gnomAD
rs551874067	p.Thr103Arg	missense variant	-	NC_000006.12:g.12294015C>G	ExAC,gnomAD
rs551874067	p.Thr103Lys	missense variant	-	NC_000006.12:g.12294015C>A	ExAC,gnomAD
rs369379949	p.Arg105Cys	missense variant	-	NC_000006.12:g.12294020C>T	ESP,ExAC,TOPMed,gnomAD
rs140854546	p.Arg105Leu	missense variant	-	NC_000006.12:g.12294021G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs140854546	p.Arg105His	missense variant	-	NC_000006.12:g.12294021G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1255912131	p.Glu106Gly	missense variant	-	NC_000006.12:g.12294024A>G	TOPMed
rs779139823	p.Glu106Lys	missense variant	-	NC_000006.12:g.12294023G>A	ExAC,gnomAD
rs917166185	p.Arg108Gly	missense variant	-	NC_000006.12:g.12294029A>G	NCI-TCGA Cosmic
rs917166185	p.Arg108Gly	missense variant	-	NC_000006.12:g.12294029A>G	gnomAD
COSM1072812	p.Arg108Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12294030G>C	NCI-TCGA Cosmic
rs1175229600	p.Ala112Ser	missense variant	-	NC_000006.12:g.12294041G>T	TOPMed,gnomAD
rs1175229600	p.Ala112Thr	missense variant	-	NC_000006.12:g.12294041G>A	TOPMed,gnomAD
rs1385040497	p.Ser113Gly	missense variant	-	NC_000006.12:g.12294044A>G	TOPMed
rs761581288	p.Asp116Asn	missense variant	-	NC_000006.12:g.12294053G>A	NCI-TCGA,NCI-TCGA Cosmic
rs761581288	p.Asp116Asn	missense variant	-	NC_000006.12:g.12294053G>A	TOPMed,gnomAD
COSM450426	p.Asp116Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12294053G>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Lys117Asn	missense variant	-	NC_000006.12:g.12294058G>C	NCI-TCGA
rs150128166	p.Lys118Asn	missense variant	-	NC_000006.12:g.12294061G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs769329570	p.Lys118Arg	missense variant	-	NC_000006.12:g.12294060A>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Cys119Arg	missense variant	-	NC_000006.12:g.12294062T>C	NCI-TCGA
COSM3620078	p.Trp120Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000006.12:g.12294067G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Cys123AlaPheSerTerUnkUnk	frameshift	-	NC_000006.12:g.12294070T>-	NCI-TCGA
rs762660018	p.Ala125Thr	missense variant	-	NC_000006.12:g.12294080G>A	ExAC,gnomAD
rs1438183776	p.Gly126Ala	missense variant	-	NC_000006.12:g.12294084G>C	gnomAD
NCI-TCGA novel	p.Lys127Gln	missense variant	-	NC_000006.12:g.12294086A>C	NCI-TCGA
rs1041556753	p.Glu128Gln	missense variant	-	NC_000006.12:g.12294089G>C	TOPMed,gnomAD
COSM3620079	p.Glu128Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12294089G>A	NCI-TCGA Cosmic
rs1365426094	p.Asp133Val	missense variant	-	NC_000006.12:g.12294269A>T	gnomAD
rs779053288	p.Ile134Ser	missense variant	-	NC_000006.12:g.12294272T>G	ExAC,gnomAD
rs568430735	p.Met135Thr	missense variant	-	NC_000006.12:g.12294275T>C	1000Genomes,ExAC,TOPMed,gnomAD
rs748326404	p.Met135Val	missense variant	-	NC_000006.12:g.12294274A>G	ExAC,gnomAD
rs1326240684	p.Met135Ile	missense variant	-	NC_000006.12:g.12294276G>C	gnomAD
NCI-TCGA novel	p.Glu136Ter	stop gained	-	NC_000006.12:g.12294277G>T	NCI-TCGA
NCI-TCGA novel	p.Asp138Tyr	missense variant	-	NC_000006.12:g.12294283G>T	NCI-TCGA
rs1376601768	p.Asp138His	missense variant	-	NC_000006.12:g.12294283G>C	TOPMed,gnomAD
rs778052405	p.Lys143Glu	missense variant	-	NC_000006.12:g.12294298A>G	ExAC,gnomAD
rs149750515	p.Lys144Glu	missense variant	-	NC_000006.12:g.12294301A>G	ESP,ExAC,TOPMed,gnomAD
COSM4911945	p.Lys146Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12294307A>G	NCI-TCGA Cosmic
rs771602064	p.Cys148Tyr	missense variant	-	NC_000006.12:g.12294314G>A	ExAC,TOPMed,gnomAD
rs771602064	p.Cys148Ser	missense variant	-	NC_000006.12:g.12294314G>C	ExAC,TOPMed,gnomAD
rs777308039	p.Ser149Tyr	missense variant	-	NC_000006.12:g.12294317C>A	ExAC,gnomAD
rs777308039	p.Ser149Tyr	missense variant	-	NC_000006.12:g.12294317C>A	NCI-TCGA,NCI-TCGA Cosmic
rs1178209473	p.Leu151Phe	missense variant	-	NC_000006.12:g.12294322C>T	TOPMed
rs762501115	p.Lys153Glu	missense variant	-	NC_000006.12:g.12294328A>G	ExAC,TOPMed,gnomAD
COSM3171322	p.Lys154SerPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000006.12:g.12294328A>-	NCI-TCGA Cosmic
rs768294608	p.Cys155Tyr	missense variant	-	NC_000006.12:g.12294335G>A	ExAC,TOPMed,gnomAD
rs1198589540	p.Cys155Arg	missense variant	-	NC_000006.12:g.12294334T>C	TOPMed
rs1176491837	p.Ile156Phe	missense variant	-	NC_000006.12:g.12294337A>T	gnomAD
rs773985828	p.Gln158Ter	stop gained	-	NC_000006.12:g.12294343C>T	ExAC,gnomAD
rs767323529	p.Leu160Ile	missense variant	-	NC_000006.12:g.12294349T>A	ExAC,gnomAD
rs145546137	p.Leu160Phe	missense variant	-	NC_000006.12:g.12294351A>C	ESP,ExAC,TOPMed,gnomAD
rs537170013	p.Val161Ala	missense variant	-	NC_000006.12:g.12294353T>C	1000Genomes,ExAC,gnomAD
rs951534547	p.Val161Met	missense variant	-	NC_000006.12:g.12294352G>A	TOPMed,gnomAD
rs753790282	p.Gly163Glu	missense variant	-	NC_000006.12:g.12294359G>A	ExAC
rs756265142	p.Gly163Arg	missense variant	-	NC_000006.12:g.12294358G>A	TOPMed,gnomAD
NCI-TCGA novel	p.Lys165SerPheSerTerUnk	frameshift	-	NC_000006.12:g.12294362_12294363insGAGTTCAGGAGGCTGTT	NCI-TCGA
rs983858211	p.Ile166Thr	missense variant	-	NC_000006.12:g.12294368T>C	gnomAD
NCI-TCGA novel	p.Arg167Ser	missense variant	-	NC_000006.12:g.12294372A>T	NCI-TCGA
rs754988566	p.Arg168Ser	missense variant	-	NC_000006.12:g.12294375A>C	ExAC
rs1420659324	p.Ser169Cys	missense variant	-	NC_000006.12:g.12294376A>T	gnomAD
rs1342307965	p.Glu172Asp	missense variant	-	NC_000006.12:g.12294387A>T	gnomAD
rs765372578	p.Glu172Gly	missense variant	-	NC_000006.12:g.12294386A>G	ExAC,TOPMed,gnomAD
rs1394694565	p.His173Gln	missense variant	-	NC_000006.12:g.12294390C>A	TOPMed
RCV000514748	p.His173Asn	missense variant	-	NC_000006.12:g.12294388C>A	ClinVar
rs149316725	p.His173Asn	missense variant	-	NC_000006.12:g.12294388C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1316232630	p.Gln176Pro	missense variant	-	NC_000006.12:g.12294398A>C	NCI-TCGA
rs1200761474	p.Gln176His	missense variant	-	NC_000006.12:g.12294399A>C	gnomAD
rs1316232630	p.Gln176Pro	missense variant	-	NC_000006.12:g.12294398A>C	gnomAD
rs1402092062	p.Thr177Ser	missense variant	-	NC_000006.12:g.12294401C>G	TOPMed
rs1358679492	p.Ser179Thr	missense variant	-	NC_000006.12:g.12295963T>A	gnomAD
rs140345259	p.Ser179Leu	missense variant	-	NC_000006.12:g.12295964C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1367113386	p.Glu180Asp	missense variant	-	NC_000006.12:g.12295968G>T	gnomAD
rs1184921074	p.Thr181Asn	missense variant	-	NC_000006.12:g.12295970C>A	TOPMed
rs772676972	p.Met182Leu	missense variant	-	NC_000006.12:g.12295972A>C	ExAC,gnomAD
COSM3620080	p.Met182Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12295974G>A	NCI-TCGA Cosmic
rs1349873879	p.Arg183Thr	missense variant	-	NC_000006.12:g.12295976G>C	gnomAD
rs6413478	p.Val186Ile	missense variant	-	NC_000006.12:g.12295984G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
COSM450428	p.Val186Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12295985T>A	NCI-TCGA Cosmic
rs770703131	p.Ser189Ala	missense variant	-	NC_000006.12:g.12295993T>G	ExAC,TOPMed,gnomAD
rs776454893	p.Phe190Leu	missense variant	-	NC_000006.12:g.12295998T>G	ExAC,TOPMed,gnomAD
rs769575571	p.Asp192Val	missense variant	-	NC_000006.12:g.12296003A>T	ExAC,gnomAD
rs759433680	p.Asp192His	missense variant	-	NC_000006.12:g.12296002G>C	ExAC,gnomAD
rs769575571	p.Asp192Gly	missense variant	-	NC_000006.12:g.12296003A>G	ExAC,gnomAD
COSM3620081	p.Asp192Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12296002G>A	NCI-TCGA Cosmic
rs113451805	p.Lys194Arg	missense variant	-	NC_000006.12:g.12296009A>G	gnomAD
rs113451805	p.Lys194Thr	missense variant	-	NC_000006.12:g.12296009A>C	gnomAD
COSM3857975	p.Lys194Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000006.12:g.12296010G>T	NCI-TCGA Cosmic
rs1455015366	p.Lys196Glu	missense variant	-	NC_000006.12:g.12296014A>G	gnomAD
NCI-TCGA novel	p.Gly197Asp	missense variant	-	NC_000006.12:g.12296018G>A	NCI-TCGA
rs146590760	p.Gly197Ala	missense variant	-	NC_000006.12:g.12296018G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs5370	p.Lys198Asn	missense variant	-	NC_000006.12:g.12296022G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs5370	p.Lys198Asn	missense variant	-	NC_000006.12:g.12296022G>T	UniProt,dbSNP
VAR_014188	p.Lys198Asn	missense variant	-	NC_000006.12:g.12296022G>T	UniProt
rs764236555	p.Lys198Arg	missense variant	-	NC_000006.12:g.12296021A>G	ExAC,gnomAD
RCV000018132	p.Lys198Asn	missense variant	High density lipoprotein cholesterol level quantitative trait locus 7 (HDLCQ7)	NC_000006.12:g.12296022G>T	ClinVar
rs533222953	p.Pro199Ser	missense variant	-	NC_000006.12:g.12296023C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs767963465	p.Pro199Leu	missense variant	-	NC_000006.12:g.12296024C>T	ExAC,gnomAD
rs756571269	p.Arg201Gly	missense variant	-	NC_000006.12:g.12296029A>G	ExAC,gnomAD
rs914099869	p.Glu202Lys	missense variant	-	NC_000006.12:g.12296032G>A	TOPMed,gnomAD
rs143255118	p.Arg203His	missense variant	-	NC_000006.12:g.12296036G>A	ESP,TOPMed,gnomAD
rs370693989	p.Arg203Cys	missense variant	-	NC_000006.12:g.12296035C>T	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Tyr204Phe	missense variant	-	NC_000006.12:g.12296039A>T	NCI-TCGA
rs1284339791	p.Tyr204Cys	missense variant	-	NC_000006.12:g.12296039A>G	gnomAD
rs777403291	p.Arg209Gln	missense variant	-	NC_000006.12:g.12296054G>A	ExAC,TOPMed,gnomAD
rs202114325	p.Arg209Ter	stop gained	-	NC_000006.12:g.12296053C>T	ESP,ExAC,TOPMed,gnomAD
rs1168389266	p.Ala210Val	missense variant	-	NC_000006.12:g.12296057C>T	TOPMed
rs746637605	p.His211Arg	missense variant	-	NC_000006.12:g.12296060A>G	ExAC
rs745611684	p.Trp212Cys	missense variant	-	NC_000006.12:g.12296064G>C	ExAC,gnomAD
rs780851020	p.Trp212Arg	missense variant	-	NC_000006.12:g.12296062T>C	ExAC,TOPMed,gnomAD
rs745611684	p.Trp212Ter	stop gained	-	NC_000006.12:g.12296064G>A	ExAC,gnomAD
rs1422191247	p.Ter213Trp	stop lost	-	NC_000006.12:g.12296067A>G	gnomAD
rs769642311	p.Ter213Arg	stop lost	-	NC_000006.12:g.12296065T>A	ExAC,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0001339	Acute pancreatitis	disease	BEFREE
C0001430	Adenoma	group	BEFREE
C0001849	AIDS Dementia Complex	disease	BEFREE
C0002152	Alloxan Diabetes	disease	CTD_human
C0002395	Alzheimer's Disease	disease	BEFREE
C0002726	Amyloidosis	disease	BEFREE
C0002736	Amyotrophic Lateral Sclerosis	disease	BEFREE
C0002895	Anemia, Sickle Cell	disease	BEFREE
C0002963	Angina Pectoris, Variant	disease	BEFREE
C0003130	Anoxia	phenotype	LHGDN
C0003467	Anxiety	disease	BEFREE
C0003469	Anxiety Disorders	group	BEFREE
C0003486	Aortic Aneurysm	disease	BEFREE
C0003504	Aortic Valve Insufficiency	disease	BEFREE
C0003507	Aortic Valve Stenosis	disease	BEFREE
C0003811	Cardiac Arrhythmia	phenotype	CTD_human
C0003850	Arteriosclerosis	disease	BEFREE
C0003857	Congenital arteriovenous malformation	disease	BEFREE
C0003873	Rheumatoid Arthritis	disease	BEFREE;LHGDN
C0004096	Asthma	disease	BEFREE;CTD_human;LHGDN
C0004114	Astrocytoma	disease	BEFREE
C0004135	Ataxia Telangiectasia	disease	BEFREE
C0004153	Atherosclerosis	disease	BEFREE;LHGDN
C0004238	Atrial Fibrillation	disease	BEFREE;CTD_human
C0004623	Bacterial Infections	group	BEFREE
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE;LHGDN
C0006111	Brain Diseases	group	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0007102	Malignant tumor of colon	disease	BEFREE
C0007103	Malignant neoplasm of endometrium	disease	BEFREE
C0007112	Adenocarcinoma of prostate	disease	BEFREE
C0007115	Malignant neoplasm of thyroid	disease	BEFREE
C0007117	Basal cell carcinoma	disease	LHGDN
C0007134	Renal Cell Carcinoma	disease	BEFREE;LHGDN
C0007137	Squamous cell carcinoma	disease	BEFREE;LHGDN
C0007193	Cardiomyopathy, Dilated	group	BEFREE
C0007194	Hypertrophic Cardiomyopathy	disease	BEFREE;RGD
C0007222	Cardiovascular Diseases	group	BEFREE;CTD_human
C0007302	Cartilage Diseases	group	CTD_human
C0007621	Neoplastic Cell Transformation	phenotype	CTD_human
C0007766	Intracranial Aneurysm	disease	BEFREE
C0007772	Intracranial Arteriovenous Malformation	disease	BEFREE
C0007786	Brain Ischemia	disease	RGD
C0007820	Cerebrovascular Disorders	group	CTD_human
C0007873	Uterine Cervical Neoplasm	disease	BEFREE
C0008479	Chondrosarcoma	disease	BEFREE
C0008497	Choriocarcinoma	disease	BEFREE
C0009375	Colonic Neoplasms	group	LHGDN
C0009402	Colorectal Carcinoma	disease	BEFREE
C0009404	Colorectal Neoplasms	group	LHGDN
C0010054	Coronary Arteriosclerosis	disease	BEFREE;RGD
C0010068	Coronary heart disease	disease	BEFREE;RGD
C0010073	Coronary Artery Vasospasm	disease	BEFREE
C0010709	Cyst	phenotype	LHGDN
C0011570	Mental Depression	disease	BEFREE
C0011581	Depressive disorder	disease	BEFREE
C0011603	Dermatitis	disease	BEFREE
C0011615	Dermatitis, Atopic	disease	BEFREE
C0011644	Scleroderma	disease	BEFREE
C0011847	Diabetes	disease	BEFREE
C0011849	Diabetes Mellitus	group	BEFREE
C0011853	Diabetes Mellitus, Experimental	disease	CTD_human
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	disease	BEFREE;CTD_human;RGD
C0011875	Diabetic Angiopathies	disease	BEFREE
C0011881	Diabetic Nephropathy	disease	BEFREE
C0011884	Diabetic Retinopathy	disease	BEFREE;LHGDN;RGD
C0012754	Distemper	disease	BEFREE
C0013274	Patent ductus arteriosus	disease	BEFREE
C0013537	Eclampsia	disease	BEFREE
C0013595	Eczema	disease	BEFREE
C0013882	Elephantiasis	disease	BEFREE
C0014038	Encephalitis	disease	BEFREE
C0015397	Disorder of eye	group	BEFREE
C0015934	Fetal Growth Retardation	phenotype	LHGDN
C0016053	Fibromyalgia	disease	BEFREE
C0016059	Fibrosis	phenotype	LHGDN
C0016085	Filariasis	disease	BEFREE;LHGDN
C0017178	Gastrointestinal Diseases	group	CTD_human
C0017601	Glaucoma	disease	BEFREE
C0017636	Glioblastoma	disease	BEFREE;LHGDN
C0017638	Glioma	disease	BEFREE
C0017661	IGA Glomerulonephritis	disease	LHGDN
C0017662	Glomerulonephritis, Membranoproliferative	disease	RGD
C0017668	Focal glomerulosclerosis	disease	CTD_human
C0018022	Endemic goiter	disease	LHGDN
C0018213	Graves Disease	disease	BEFREE
C0018621	Hay fever	disease	LHGDN
C0018790	Cardiac Arrest	disease	BEFREE
C0018798	Congenital Heart Defects	group	CTD_human
C0018799	Heart Diseases	group	BEFREE;LHGDN;RGD
C0018800	Cardiomegaly	phenotype	CTD_human;LHGDN
C0018801	Heart failure	disease	BEFREE;CTD_human;LHGDN;RGD
C0018802	Congestive heart failure	disease	BEFREE;CTD_human;RGD
C0019212	Hepatorenal Syndrome	disease	CTD_human
C0019284	Diaphragmatic Hernia	phenotype	CTD_human
C0019348	Herpes Simplex Infections	group	BEFREE
C0019693	HIV Infections	group	BEFREE
C0020428	Hyperaldosteronism	disease	BEFREE
C0020429	Hyperalgesia	phenotype	BEFREE;CTD_human
C0020443	Hypercholesterolemia	disease	CTD_human
C0020445	Hypercholesterolemia, Familial	disease	BEFREE
C0020456	Hyperglycemia	disease	BEFREE;LHGDN
C0020529	Hypersomnia with Periodic Respiration	disease	RGD
C0020538	Hypertensive disease	group	BEFREE;CTD_human;LHGDN;RGD
C0020541	Hypertension, Portal	disease	BEFREE;RGD
C0020542	Pulmonary Hypertension	phenotype	CTD_human;LHGDN;RGD
C0020544	Renal hypertension	disease	BEFREE
C0020550	Hyperthyroidism	disease	BEFREE
C0020564	Hypertrophy	phenotype	CTD_human
C0020619	Hypogonadism	disease	RGD
C0020649	Hypotension	phenotype	CTD_human;LHGDN
C0021368	Inflammation	phenotype	CTD_human
C0021390	Inflammatory Bowel Diseases	group	BEFREE
C0022116	Ischemia	phenotype	LHGDN
C0022603	Seborrheic keratosis	disease	BEFREE
C0022658	Kidney Diseases	group	BEFREE;CTD_human
C0022660	Kidney Failure, Acute	disease	BEFREE;CTD_human
C0022661	Kidney Failure, Chronic	disease	BEFREE;RGD
C0022680	Polycystic Kidney Diseases	group	LHGDN
C0023212	Left-Sided Heart Failure	disease	CTD_human
C0023264	Leigh Disease	disease	BEFREE
C0023267	Fibroid Tumor	group	BEFREE
C0023321	Lentigo	disease	BEFREE
C0023434	Chronic Lymphocytic Leukemia	disease	BEFREE
C0023890	Liver Cirrhosis	disease	BEFREE;RGD
C0023893	Liver Cirrhosis, Experimental	disease	CTD_human
C0023895	Liver diseases	group	BEFREE
C0024115	Lung diseases	group	BEFREE
C0024117	Chronic Obstructive Airway Disease	disease	BEFREE;LHGDN
C0024121	Lung Neoplasms	group	BEFREE;LHGDN
C0024141	Lupus Erythematosus, Systemic	disease	LHGDN
C0024530	Malaria	disease	LHGDN
C0024799	Marginal ulcer	disease	CTD_human
C0025007	Measles	disease	BEFREE
C0025202	melanoma	disease	BEFREE;LHGDN
C0025209	Melanosis	disease	BEFREE
C0025286	Meningioma	disease	BEFREE
C0025517	Metabolic Diseases	group	BEFREE
C0025945	Microangiopathy, Diabetic	disease	BEFREE
C0025990	Micrognathism	disease	HPO
C0027051	Myocardial Infarction	disease	BEFREE;LHGDN;RGD
C0027055	Myocardial Reperfusion Injury	phenotype	CTD_human
C0027627	Neoplasm Metastasis	phenotype	BEFREE;LHGDN
C0027651	Neoplasms	group	BEFREE
C0027697	Nephritis	disease	RGD
C0027720	Nephrosis	disease	CTD_human;RGD
C0027726	Nephrotic Syndrome	group	BEFREE
C0027819	Neuroblastoma	group	BEFREE
C0028754	Obesity	disease	BEFREE
C0029132	Disorder of the optic nerve	group	BEFREE
C0029408	Degenerative polyarthritis	disease	BEFREE;LHGDN
C0029463	Osteosarcoma	disease	BEFREE
C0029866	Other ureteric obstruction	phenotype	RGD
C0029925	Ovarian Carcinoma	disease	BEFREE
C0030193	Pain	phenotype	BEFREE;CTD_human
C0030305	Pancreatitis	disease	LHGDN
C0030567	Parkinson Disease	disease	CTD_human
C0030920	Peptic Ulcer	disease	CTD_human
C0031090	Periodontal Diseases	group	LHGDN
C0032290	Aspiration Pneumonia	disease	RGD
C0032461	Polycythemia	disease	BEFREE;LHGDN
C0032914	Pre-Eclampsia	phenotype	CTD_human;LHGDN
C0033141	Cardiomyopathies, Primary	group	CTD_human
C0033377	Ptosis	disease	BEFREE
C0033578	Prostatic Neoplasms	group	LHGDN
C0033774	Pruritus	phenotype	BEFREE
C0033847	Pseudoxanthoma Elasticum	disease	BEFREE
C0033860	Psoriasis	disease	BEFREE
C0034065	Pulmonary Embolism	disease	RGD
C0034069	Pulmonary Fibrosis	disease	BEFREE;CTD_human;LHGDN;RGD
C0034150	Purpura	disease	LHGDN
C0034735	Raynaud Phenomenon	disease	BEFREE
C0035078	Kidney Failure	disease	BEFREE;CTD_human;RGD
C0035126	Reperfusion Injury	disease	CTD_human
C0035222	Respiratory Distress Syndrome, Adult	disease	CTD_human;RGD
C0035305	Retinal Detachment	disease	LHGDN
C0035309	Retinal Diseases	group	BEFREE
C0035328	Retinal Vein Occlusion	disease	BEFREE
C0035344	Retinopathy of Prematurity	disease	BEFREE
C0036220	Kaposi Sarcoma	disease	BEFREE
C0036421	Systemic Scleroderma	disease	BEFREE;LHGDN
C0036529	Myocardial Diseases, Secondary	group	CTD_human
C0036572	Seizures	phenotype	BEFREE
C0036651	Senile lentigo	disease	BEFREE
C0036690	Septicemia	disease	BEFREE
C0036983	Septic Shock	phenotype	LHGDN
C0037315	Sleep Apnea Syndromes	group	RGD
C0038358	Gastric ulcer	disease	LHGDN
C0038433	Streptozotocin Diabetes	disease	CTD_human
C0038454	Cerebrovascular accident	group	BEFREE;CTD_human;LHGDN
C0038505	Sturge-Weber Syndrome	disease	BEFREE
C0038522	Subacute Sclerosing Panencephalitis	disease	BEFREE
C0038525	Subarachnoid Hemorrhage	disease	BEFREE;CTD_human;LHGDN
C0039070	Syncope	phenotype	BEFREE
C0039103	Synovitis	disease	BEFREE
C0039483	Giant Cell Arteritis	disease	BEFREE
C0040147	Thyroiditis	disease	BEFREE
C0041948	Uremia	disease	RGD
C0041956	Ureteral obstruction	phenotype	CTD_human
C0042133	Uterine Fibroids	group	BEFREE
C0042138	Uterine Neoplasms	group	BEFREE
C0042373	Vascular Diseases	group	BEFREE
C0042514	Tachycardia, Ventricular	disease	LHGDN
C0042900	Vitiligo	disease	BEFREE
C0080274	Urinary Retention	phenotype	CTD_human
C0085278	Antiphospholipid Syndrome	disease	BEFREE
C0085409	Polyendocrinopathies, Autoimmune	group	BEFREE
C0085413	Polycystic Kidney, Autosomal Dominant	disease	BEFREE
C0085580	Essential Hypertension	disease	BEFREE
C0085700	Chondromalacia	disease	CTD_human
C0085786	Hamman-Rich syndrome	disease	BEFREE;CTD_human
C0086432	Hyalinosis, Segmental Glomerular	disease	CTD_human
C0149521	Pancreatitis, Chronic	disease	BEFREE
C0149721	Left Ventricular Hypertrophy	disease	BEFREE;CTD_human;LHGDN
C0149745	Oral Ulcer	disease	CTD_human
C0149931	Migraine Disorders	group	BEFREE
C0151526	Premature Birth	phenotype	CTD_human
C0151650	Renal fibrosis	disease	BEFREE
C0151744	Myocardial Ischemia	disease	BEFREE;CTD_human;RGD
C0151747	Renal tubular disorder	group	BEFREE
C0152101	Hypoplastic Left Heart Syndrome	disease	BEFREE;LHGDN
C0152171	Idiopathic pulmonary hypertension	disease	BEFREE
C0152424	Common ventricle	disease	BEFREE
C0153676	Secondary malignant neoplasm of lung	disease	BEFREE
C0153690	Secondary malignant neoplasm of bone	disease	BEFREE
C0154723	Migraine with Aura	disease	BEFREE
C0154830	Proliferative diabetic retinopathy	disease	BEFREE
C0155626	Acute myocardial infarction	disease	BEFREE
C0155765	Disease of capillaries	group	BEFREE
C0156353	Uterovaginal prolapse	phenotype	BEFREE
C0158266	Intervertebral Disc Degeneration	disease	BEFREE
C0158570	Vascular anomaly	phenotype	BEFREE
C0178664	Glomerulosclerosis (disorder)	disease	BEFREE
C0178874	Tumor Progression	phenotype	BEFREE
C0206172	Diabetic Foot	disease	BEFREE
C0206686	Adrenocortical carcinoma	disease	BEFREE
C0206698	Cholangiocarcinoma	disease	BEFREE
C0221391	Melanosis coli	disease	BEFREE
C0234230	Pain, Burning	phenotype	CTD_human
C0234238	Ache	phenotype	CTD_human
C0234254	Radiating pain	phenotype	CTD_human
C0235480	Paroxysmal atrial fibrillation	disease	CTD_human
C0235527	Heart Failure, Right-Sided	disease	CTD_human
C0235833	Congenital diaphragmatic hernia	disease	BEFREE
C0238281	Middle Cerebral Artery Syndrome	disease	CTD_human
C0238463	Papillary thyroid carcinoma	disease	BEFREE
C0241832	Cerebrovascular Insufficiency	disease	CTD_human
C0242350	Erectile dysfunction	disease	BEFREE;CTD_human;RGD
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0242488	Acute Lung Injury	disease	CTD_human
C0242698	Ventricular Dysfunction, Left	phenotype	LHGDN
C0242852	Proliferative vitreoretinopathy	disease	BEFREE
C0242966	Systemic Inflammatory Response Syndrome	disease	LHGDN
C0242973	Ventricular Dysfunction	phenotype	LHGDN
C0243026	Sepsis	disease	BEFREE;LHGDN
C0243050	Cardiovascular Abnormalities	group	CTD_human
C0263630	Hypertrophic disorder of skin, unspecified	group	BEFREE
C0264408	Childhood asthma	disease	BEFREE
C0264694	Chronic myocardial ischemia	disease	RGD
C0264716	Chronic heart failure	disease	BEFREE
C0266122	Cleft uvula	disease	HPO
C0266929	Chronic Periodontitis	disease	BEFREE
C0267048	Glossoptosis	disease	HPO
C0268233	GALACTOSIALIDOSIS	disease	BEFREE
C0268731	Renal glomerular disease	group	BEFREE
C0268790	Renal vascular disorder	group	RGD
C0268849	Overactive Detrusor	disease	CTD_human
C0270192	Perinatal Subarachnoid Hemorrhage	phenotype	CTD_human
C0278488	Carcinoma breast stage IV	disease	BEFREE
C0278512	Metastatic osteosarcoma	disease	BEFREE
C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	disease	BEFREE
C0302592	Cervix carcinoma	disease	BEFREE
C0333559	Infarction, Lacunar	disease	BEFREE
C0338495	Sleep Apnea, Mixed Central and Obstructive	disease	RGD
C0339543	Epiretinal Membrane	phenotype	BEFREE
C0339573	Glaucoma, Primary Open Angle	disease	BEFREE
C0340100	High altitude pulmonary edema	disease	BEFREE
C0343084	Capillary Leak Syndrome	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0376634	Craniofacial Abnormalities	group	CTD_human
C0406317	Chronic small plaque psoriasis	disease	BEFREE
C0428977	Bradycardia	phenotype	CTD_human
C0458247	Allodynia	phenotype	CTD_human
C0458257	Pain, Splitting	phenotype	CTD_human
C0458259	Pain, Crushing	phenotype	CTD_human
C0472383	Subarachnoid Hemorrhage, Spontaneous	phenotype	CTD_human
C0473583	Nevus elasticus	disease	BEFREE
C0476089	Endometrial Carcinoma	disease	BEFREE
C0497406	Overweight	phenotype	BEFREE
C0520679	Sleep Apnea, Obstructive	disease	BEFREE;LHGDN
C0525045	Mood Disorders	group	BEFREE;PSYGENET
C0549473	Thyroid carcinoma	disease	BEFREE
C0559031	Functional Gastrointestinal Disorders	disease	CTD_human
C0563625	Agnosia for Pain	disease	BEFREE
C0582415	Acute asthma	disease	BEFREE
C0585442	Osteosarcoma of bone	disease	BEFREE
C0596240	Cancer Pain	phenotype	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0596298	Cerebrovascular Occlusion	disease	CTD_human
C0598428	genetic hypertension	disease	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0600452	Hepatopulmonary Syndrome	disease	RGD
C0677607	Hashimoto Disease	disease	BEFREE;LHGDN
C0677886	Epithelial ovarian cancer	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0684249	Carcinoma of lung	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0700095	Central neuroblastoma	disease	BEFREE
C0740376	Middle Cerebral Artery Thrombosis	disease	CTD_human
C0740391	Middle Cerebral Artery Occlusion	phenotype	BEFREE;CTD_human
C0740392	Infarction, Middle Cerebral Artery	disease	CTD_human
C0741923	cardiac event	phenotype	BEFREE
C0742343	Acute Chest Syndrome	disease	BEFREE
C0745103	Hyperlipoproteinemia Type IIa	disease	BEFREE
C0750151	Vaso-Occlusive Crisis	disease	BEFREE
C0751211	Hyperalgesia, Primary	phenotype	CTD_human
C0751212	Hyperalgesia, Secondary	phenotype	CTD_human
C0751213	Tactile Allodynia	phenotype	CTD_human
C0751214	Hyperalgesia, Thermal	phenotype	CTD_human
C0751407	Pain, Migratory	phenotype	CTD_human
C0751408	Suffering, Physical	phenotype	CTD_human
C0751436	Hyperphenylalaninemia, Non-Phenylketonuric	disease	BEFREE
C0751530	Subarachnoid Hemorrhage, Aneurysmal	phenotype	CTD_human
C0751845	Middle Cerebral Artery Embolus	disease	CTD_human
C0751846	Left Middle Cerebral Artery Infarction	disease	CTD_human
C0751847	Embolic Infarction, Middle Cerebral Artery	disease	CTD_human
C0751848	Thrombotic Infarction, Middle Cerebral Artery	disease	CTD_human
C0751849	Right Middle Cerebral Artery Infarction	disease	CTD_human
C0751956	Acute Cerebrovascular Accidents	disease	CTD_human
C0752120	Spinocerebellar Ataxia Type 1	disease	BEFREE
C0752347	Lewy Body Disease	disease	BEFREE;CTD_human
C0795688	Subarachnoid Hemorrhage, Intracranial	phenotype	CTD_human
C0852949	Arteriopathic disease	group	BEFREE
C0853897	Diabetic Cardiomyopathies	disease	BEFREE
C0856169	Endothelial dysfunction	phenotype	BEFREE
C0878544	Cardiomyopathies	group	BEFREE;CTD_human
C0878773	Overactive Bladder	disease	CTD_human
C0919267	ovarian neoplasm	disease	BEFREE;LHGDN
C0936223	Metastatic Prostate Carcinoma	disease	BEFREE
C0949658	Cardiomyopathy, Hypertrophic, Familial	disease	RGD
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1153706	Endometrial adenocarcinoma	disease	BEFREE
C1281300	Vascular degeneration	disease	BEFREE
C1282496	Metastasis from malignant tumor of prostate	disease	BEFREE
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1332986	Childhood Osteosarcoma	disease	BEFREE
C1335729	Refractory Neoplasm	disease	BEFREE
C1378703	Renal carcinoma	disease	BEFREE
C1383860	Cardiac Hypertrophy	phenotype	CTD_human
C1384514	Conn Syndrome	disease	BEFREE
C1397307	Cardiac fibrosis	disease	BEFREE
C1449563	Cardiomyopathy, Familial Idiopathic	disease	BEFREE
C1458155	Mammary Neoplasms	group	LHGDN
C1512409	Hepatocarcinogenesis	disease	BEFREE
C1512508	Human herpesvirus 8 infection	disease	BEFREE
C1519670	Tumor Angiogenesis	phenotype	BEFREE
C1527249	Colorectal Cancer	disease	BEFREE
C1527311	Brain Edema	disease	LHGDN
C1561643	Chronic Kidney Diseases	group	BEFREE
C1565321	Cholera Infantum	disease	CTD_human
C1565489	Renal Insufficiency	disease	BEFREE;CTD_human
C1565662	Acute Kidney Insufficiency	disease	CTD_human
C1623038	Cirrhosis	disease	BEFREE
C1654637	androgen independent prostate cancer	disease	BEFREE
C1704272	Benign Prostatic Hyperplasia	disease	BEFREE
C1704436	Peripheral Arterial Diseases	group	BEFREE
C1720771	Testicular Hydrocele	disease	BEFREE
C1762616	Meningioma, benign, no ICD-O subtype	disease	BEFREE
C1800706	Idiopathic Pulmonary Fibrosis	disease	BEFREE
C1840311	Laryngeal cleft	disease	HPO
C1847835	VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	disease	BEFREE
C1857130	Hypoplastic mandible condyle	phenotype	HPO
C1861172	Venous Thromboembolism	phenotype	BEFREE
C1865295	Auriculo-condylar syndrome	disease	BEFREE;CTD_human;ORPHANET
C1866231	Full cheeks	phenotype	HPO
C1883486	Uterine Corpus Cancer	disease	BEFREE
C1956346	Coronary Artery Disease	disease	BEFREE;GWASCAT;LHGDN
C1959583	Myocardial Failure	disease	CTD_human
C1961112	Heart Decompensation	phenotype	CTD_human
C2239176	Liver carcinoma	disease	BEFREE
C2243080	Intestinal necrosis	disease	BEFREE
C2316810	Chronic kidney disease stage 5	disease	BEFREE;RGD
C2364016	Systemic sclerosis [scleroderma]	disease	BEFREE
C2585653	Persistent atrial fibrillation	phenotype	CTD_human
C2609414	Acute kidney injury	disease	CTD_human
C2711227	Steatohepatitis	disease	BEFREE
C2748545	QUESTION MARK EARS, ISOLATED	phenotype	BEFREE;CLINVAR;UNIPROT
C2748653	Chubby cheeks	phenotype	HPO
C2931822	Nasopharyngeal carcinoma	disease	BEFREE
C2936719	Mechanical Allodynia	phenotype	CTD_human
C2937421	Prostatic Hyperplasia	disease	BEFREE;LHGDN
C2939420	Metastatic Neoplasm	phenotype	BEFREE
C2945695	Limb ischemia	disease	BEFREE
C3203102	Idiopathic pulmonary arterial hypertension	disease	BEFREE
C3274516	Single Ventricle Defect	disease	BEFREE
C3468561	familial atrial fibrillation	phenotype	CTD_human
C3494422	Retrognathia	phenotype	HPO
C3532222	Inflammatory cardiomyopathy	disease	BEFREE
C3534591	Diabetic Heart Disease	disease	BEFREE
C3539878	Triple Negative Breast Neoplasms	disease	BEFREE
C3806443	Puffy cheeks	phenotype	HPO
C3810332	AURICULOCONDYLAR SYNDROME 3	disease	CLINVAR;UNIPROT
C3854173	Pre-renal acute kidney injury	disease	BEFREE
C3875321	Inflammatory dermatosis	group	BEFREE
C3887486	Interstitial lung fibrosis	phenotype	BEFREE
C3887499	Renal cyst	phenotype	BEFREE
C3887709	Optic Neuropathy	disease	BEFREE
C3888103	Question mark ear	phenotype	HPO
C3888126	HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 7	phenotype	CLINVAR
C4024589	Aplasia/Hypoplasia of the mandible	phenotype	HPO
C4280647	Hypertrophy of cheeks	phenotype	HPO
C4280648	Hyperplasia of cheeks	phenotype	HPO
C4280678	Posterior displacement of the tongue	phenotype	HPO
C4476523	Decreased projection of lower jaw	phenotype	HPO
C4476524	Decreased projection of mandible	phenotype	HPO
C4476525	Retrusion of lower jaw	phenotype	HPO
C4520898	Stage IV Breast Cancer AJCC v6 and v7	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005125	cytokine activity	IDA
GO:0005179	hormone activity	IDA
GO:0005515	protein binding	IPI
GO:0031707	endothelin A receptor binding	IDA
GO:0031708	endothelin B receptor binding	IDA
GO:0031708	endothelin B receptor binding	IPI

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
GO:0001516	prostaglandin biosynthetic process	IDA
GO:0001569	branching involved in blood vessel morphogenesis	IEA
GO:0001701	in utero embryonic development	IEA
GO:0001821	histamine secretion	IEA
GO:0003100	regulation of systemic arterial blood pressure by endothelin	IDA
GO:0006885	regulation of pH	IEA
GO:0007166	cell surface receptor signaling pathway	IDA
GO:0007186	G protein-coupled receptor signaling pathway	IDA
GO:0007186	G protein-coupled receptor signaling pathway	TAS
GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0007204	positive regulation of cytosolic calcium ion concentration	IDA
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007267	cell-cell signaling	IDA
GO:0007507	heart development	IEA
GO:0007585	respiratory gaseous exchange by respiratory system	IEA
GO:0007589	body fluid secretion	IEA
GO:0008284	positive regulation of cell population proliferation	IDA
GO:0009953	dorsal/ventral pattern formation	IEA
GO:0010193	response to ozone	IEA
GO:0010259	multicellular organism aging	IEA
GO:0010460	positive regulation of heart rate	IDA
GO:0010595	positive regulation of endothelial cell migration	TAS
GO:0010613	positive regulation of cardiac muscle hypertrophy	IDA
GO:0010827	regulation of glucose transmembrane transport	IEA
GO:0010870	positive regulation of receptor biosynthetic process	IDA
GO:0014032	neural crest cell development	IEA
GO:0014065	phosphatidylinositol 3-kinase signaling	IDA
GO:0014823	response to activity	IEA
GO:0014824	artery smooth muscle contraction	TAS
GO:0014824	artery smooth muscle contraction	IDA
GO:0014826	vein smooth muscle contraction	IDA
GO:0019229	regulation of vasoconstriction	IEA
GO:0019233	sensory perception of pain	IEA
GO:0019722	calcium-mediated signaling	IDA
GO:0030072	peptide hormone secretion	IDA
GO:0030185	nitric oxide transport	IDA
GO:0030195	negative regulation of blood coagulation	TAS
GO:0030335	positive regulation of cell migration	IDA
GO:0031583	phospholipase D-activating G protein-coupled receptor signaling pathway	IEA
GO:0032269	negative regulation of cellular protein metabolic process	IDA
GO:0032308	positive regulation of prostaglandin secretion	IEA
GO:0032496	response to lipopolysaccharide	IEA
GO:0033574	response to testosterone	IEA
GO:0034392	negative regulation of smooth muscle cell apoptotic process	IEA
GO:0034696	response to prostaglandin F	IEA
GO:0035094	response to nicotine	IEA
GO:0035690	cellular response to drug	IEA
GO:0035810	positive regulation of urine volume	IEA
GO:0035815	positive regulation of renal sodium excretion	IEA
GO:0035994	response to muscle stretch	IEA
GO:0042045	epithelial fluid transport	IEA
GO:0042310	vasoconstriction	IDA
GO:0042313	protein kinase C deactivation	IDA
GO:0042474	middle ear morphogenesis	IEA
GO:0042482	positive regulation of odontogenesis	IEA
GO:0042554	superoxide anion generation	IEA
GO:0043179	rhythmic excitation	IEA
GO:0043200	response to amino acid	IEA
GO:0043406	positive regulation of MAP kinase activity	IDA
GO:0043507	positive regulation of JUN kinase activity	IDA
GO:0044321	response to leptin	IEA
GO:0045321	leukocyte activation	TAS
GO:0045429	positive regulation of nitric oxide biosynthetic process	TAS
GO:0045793	positive regulation of cell size	IDA
GO:0045840	positive regulation of mitotic nuclear division	IDA
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
GO:0045987	positive regulation of smooth muscle contraction	IEA
GO:0046887	positive regulation of hormone secretion	IDA
GO:0046888	negative regulation of hormone secretion	IEA
GO:0048016	inositol phosphate-mediated signaling	IDA
GO:0048661	positive regulation of smooth muscle cell proliferation	IDA
GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA
GO:0051216	cartilage development	IEA
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IEA
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	IDA
GO:0051899	membrane depolarization	IEA
GO:0051930	regulation of sensory perception of pain	IEA
GO:0060137	maternal process involved in parturition	IEA
GO:0060298	positive regulation of sarcomere organization	IMP
GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	IMP
GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	IDA
GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	IGI
GO:0070101	positive regulation of chemokine-mediated signaling pathway	IC
GO:0071277	cellular response to calcium ion	IEA
GO:0071346	cellular response to interferon-gamma	IEA
GO:0071347	cellular response to interleukin-1	IEA
GO:0071356	cellular response to tumor necrosis factor	IEA
GO:0071375	cellular response to peptide hormone stimulus	IEA
GO:0071385	cellular response to glucocorticoid stimulus	IEA
GO:0071389	cellular response to mineralocorticoid stimulus	IEA
GO:0071398	cellular response to fatty acid	IEA
GO:0071456	cellular response to hypoxia	IEA
GO:0071548	response to dexamethasone	IEA
GO:0071560	cellular response to transforming growth factor beta stimulus	IEA
GO:0086100	endothelin receptor signaling pathway	IMP
GO:0090023	positive regulation of neutrophil chemotaxis	IEA
GO:1901224	positive regulation of NIK/NF-kappaB signaling	IEA
GO:1902074	response to salt	IEA
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	IEA
GO:0030593	neutrophil chemotaxis	IDA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IDA
GO:0005623	cell	IEA
GO:0005737	cytoplasm	IDA
GO:0030133	transport vesicle	TAS
GO:0033093	Weibel-Palade body	IEA
GO:0045178	basal part of cell	IEA
GO:0048237	rough endoplasmic reticulum lumen	IEA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [EDN1 protein results in increased expression of GJA1 protein]	15685554
D014013	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]	17391658
C049325	1,2-dithiol-3-thione	1,2-dithiol-3-thione results in increased expression of EDN1 mRNA	19162173
C031763	1,3-butadiene	1,3-butadiene results in decreased expression of EDN1 mRNA	29038090
C038983	1,3-dimethylthiourea	1,3-dimethylthiourea results in decreased expression of EDN1 mRNA	11603923
C038983	1,3-dimethylthiourea	1,3-dimethylthiourea results in decreased expression of EDN1 protein	11603923
C038983	1,3-dimethylthiourea	1,3-dimethylthiourea results in increased expression of EDN1 protein	9357851
C050232	1,3-ditolylguanidine	1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]	9714087
C097240	15-deoxy-delta(12,14)-prostaglandin J2	15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of EDN1 protein	9920814
C095653	1,5-dihydroxyisoquinoline	1,5-dihydroxyisoquinoline results in decreased expression of EDN1 mRNA	12824290
C095653	1,5-dihydroxyisoquinoline	1,5-dihydroxyisoquinoline results in decreased expression of EDN1 protein	12824290
D019796	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid	[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in decreased chemical synthesis of 6-Ketoprostaglandin F1 alpha	16325014
D019796	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid	[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in decreased chemical synthesis of Dinoprostone	16325014
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]	14759557
D000077713	17 alpha-Hydroxyprogesterone Caproate	17 alpha-Hydroxyprogesterone Caproate affects the expression of EDN1 mRNA	19733289
C040168	19-oxo-11-deoxycorticosterone acetate	[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA	18823320
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of EDN1 mRNA	16054899
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of EDN1 mRNA	28329830
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of EDN1 mRNA	25827057
C465664	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide inhibits the reaction [EDN1 protein results in increased phosphorylation of STAT3 protein]	30670587
C548651	2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of EDN1 mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether results in increased expression of EDN1 mRNA	25614096
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased secretion of EDN1 protein]	16373398
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]	17974986
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased phosphorylation of GATA4 protein]	11583584
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]	11583584
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]	11583584
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased expression of HOMER1 mRNA alternative form]	16786172
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased expression of JUN mRNA]	12169099
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]	12169099
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased susceptibility to EDN1 protein]	20561571
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]	14736733
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased susceptibility to EDN1 protein	18656273
C120227	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]	12411397
C120227	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [EDN1 protein results in increased phosphorylation of EIF4EBP1 protein]	12411397
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]	12411397
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EDN1 mRNA	15215175
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C488718	2'-O-methyl-8-(4-chlorophenylthio)cAMP	2'-O-methyl-8-(4-chlorophenylthio)cAMP inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]	22796455
C488718	2'-O-methyl-8-(4-chlorophenylthio)cAMP	2'-O-methyl-8-(4-chlorophenylthio)cAMP inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA]	22796455
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of EDN1 mRNA	23196670
C402306	3,5-dibromosalicylic acid	3,5-dibromosalicylic acid inhibits the reaction [Bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]	11093786
C402306	3,5-dibromosalicylic acid	3,5-dibromosalicylic acid inhibits the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]]	11093786
C402306	3,5-dibromosalicylic acid	3,5-dibromosalicylic acid inhibits the reaction [EDN1 protein binds to EDNRA protein]	11093786
C020891	3,5-diiodosalicylic acid	3,5-diiodosalicylic acid inhibits the reaction [EDN1 protein binds to EDNRA protein]	11093786
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of EDN1 mRNA	22841810
C047368	3-methylquercetin	3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]	18436224
C047368	3-methylquercetin	3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]	18436224
C446602	4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline	4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]	20177073
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of EDN1 protein	26116029
C010118	4,4'-dihydroxystilbene	4,4'-dihydroxystilbene results in decreased expression of EDN1 mRNA	21554123
C010118	4,4'-dihydroxystilbene	4,4'-dihydroxystilbene results in decreased secretion of EDN1 protein	21554123
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]	16225752
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein]	16225752
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of EDN1 mRNA	19191707
C510101	5,15-diphenylporphine	5,15-diphenylporphine inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]	30670587
C510101	5,15-diphenylporphine	5,15-diphenylporphine inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]	30670587
C510101	5,15-diphenylporphine	5,15-diphenylporphine inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]	30670587
C510101	5,15-diphenylporphine	5,15-diphenylporphine inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein]	30670587
C080669	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of EDN1 protein]	26694894
C080669	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 mRNA]	26694894
C080669	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]]	26694894
D015121	6-Ketoprostaglandin F1 alpha	[EDN1 protein co-treated with Arachidonic Acid] results in decreased abundance of 6-Ketoprostaglandin F1 alpha	18809207
D015121	6-Ketoprostaglandin F1 alpha	EDN1 protein results in decreased abundance of 6-Ketoprostaglandin F1 alpha	18809207
D015121	6-Ketoprostaglandin F1 alpha	EDN1 results in increased secretion of 6-Ketoprostaglandin F1 alpha	7507780
D015121	6-Ketoprostaglandin F1 alpha	EDN1 protein results in increased secretion of 6-Ketoprostaglandin F1 alpha	12056553
D015121	6-Ketoprostaglandin F1 alpha	Indomethacin inhibits the reaction [EDN1 protein results in increased secretion of 6-Ketoprostaglandin F1 alpha]	12056553
D015121	6-Ketoprostaglandin F1 alpha	[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in decreased chemical synthesis of 6-Ketoprostaglandin F1 alpha	16325014
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of EDN1 mRNA	20382639; 26238291;
C080122	7-nitroindazole	7-nitroindazole inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C016276	8-bromocyclic GMP	8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]	29165873
C016276	8-bromocyclic GMP	8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]	29165873
C016276	8-bromocyclic GMP	8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]	16023617
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of EDN1 mRNA	26238291
C120508	A 192621	A 192621 inhibits the reaction [EDN1 protein results in decreased secretion of TNF protein]	11994508
D000082	Acetaminophen	Acetaminophen affects the expression of EDN1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]	21811393
D000082	Acetaminophen	Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
C056165	acetovanillone	acetovanillone inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]	17391658
C056165	acetovanillone	acetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]	20977430
C056165	acetovanillone	acetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]	22431579
C056165	acetovanillone	acetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	12600921
D000109	Acetylcholine	acetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]	20977430
D000109	Acetylcholine	Catechin inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]	20977430
D000109	Acetylcholine	EDN1 protein results in decreased susceptibility to Acetylcholine	20977430
D000109	Acetylcholine	Polyphenols inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]	20977430
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]	14623829
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]	14623829
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]	21765237
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]	16261333
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]	16261333
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]	16261333
D000117	Acetylglucosamine	EDN1 protein results in increased abundance of Acetylglucosamine	19948983
D000171	Acrolein	Acrolein results in increased expression of EDN1 protein	22928487
D000171	Acrolein	cesium chloride inhibits the reaction [Acrolein results in increased expression of EDN1 protein]	22928487
D000171	Acrolein	Rotenone inhibits the reaction [Acrolein results in increased expression of EDN1 protein]	22928487
D000305	Adrenal Cortex Hormones	Adrenal Cortex Hormones results in decreased expression of EDN1 mRNA	11326888
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of EDN1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of EDN1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of EDN1 mRNA	21632981; 21641981; 27153756;
D000450	Aldosterone	Aldosterone results in increased expression of EDN1 protein	18660453
D000450	Aldosterone	[EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]	18660453
C467894	ambrisentan	ambrisentan results in decreased expression of EDN1 mRNA	16364719
C467894	ambrisentan	ambrisentan results in decreased expression of EDN1 protein	16364719
D017311	Amlodipine	Amlodipine affects the expression of EDN1 protein	11369837
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of EDN1 mRNA	16483693
D000667	Ampicillin	Ampicillin results in increased expression of EDN1 mRNA	21632981
C030419	andrographolide	andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]	27297870; 29165873;
C030419	andrographolide	andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]	29165873
C030419	andrographolide	Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]]	29165873
C030419	andrographolide	Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]]	29165873
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in decreased secretion of EDN1 protein	19079593
D018943	Anthracyclines	Anthracyclines results in decreased expression of EDN1 protein	12193102
D016718	Arachidonic Acid	Arachidonic Acid promotes the reaction [EDN1 protein inhibits the reaction [LHB protein results in increased chemical synthesis of Progesterone]]	18809207
D016718	Arachidonic Acid	[EDN1 protein co-treated with Arachidonic Acid] results in decreased abundance of 6-Ketoprostaglandin F1 alpha	18809207
D016718	Arachidonic Acid	[EDN1 protein co-treated with Arachidonic Acid] results in increased abundance of Dinoprost	18809207
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of EDN1 mRNA	26705709
C015001	arsenite	arsenite affects the expression of EDN1 mRNA	15738583
D001194	Asbestos	Asbestos results in decreased expression of EDN1 mRNA	22398240
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in decreased expression of EDN1 mRNA	29523930
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in increased expression of EDN1 mRNA	25351596
D001205	Ascorbic Acid	[Tretinoin co-treated with Ascorbic Acid] results in increased expression of EDN1 mRNA	16443354
D001262	Atenolol	EDN1 gene polymorphism affects the susceptibility to Atenolol	15188945
D000069059	Atorvastatin	Atorvastatin results in decreased expression of EDN1 mRNA alternative form	9637705
D000069059	Atorvastatin	Atorvastatin results in decreased expression of EDN1 protein	9637705
D000069059	Atorvastatin	Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of EDN1 mRNA alternative form]	9637705
D000069059	Atorvastatin	Atorvastatin results in decreased expression of EDN1 protein	16360360
D000077868	Atrasentan	Atrasentan inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]	22431579
D000077868	Atrasentan	[Atrasentan binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	12600921
D001280	Atrazine	Atrazine results in decreased expression of EDN1 mRNA	29505797
D001285	Atropine	EDN1 protein results in decreased activity of [Atropine co-treated with Histamine]	12906840
C547126	AZM551248	AZM551248 results in decreased expression of EDN1 mRNA	22323515
D001397	Azoxymethane	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of EDN1 mRNA	29950665
C487081	belinostat	belinostat results in increased expression of EDN1 mRNA	26272509
C487081	belinostat	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C044946	benazepril	benazepril results in decreased expression of EDN1 mRNA	16191423
C044946	benazepril	benazepril results in decreased expression of EDN1 protein	16191423
C044946	benazepril	benazepril results in increased activity of EDN1 protein	7528292
C044946	benazepril	[Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein	11136700
C044946	benazepril	benazepril inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]	15015294
C061004	benidipine	benidipine results in decreased expression of EDN1 protein	16387788
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of EDN1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of EDN1 mRNA	21632981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of EDN1 mRNA	20106945; 31255691;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of EDN1 mRNA	16269432; 21871943; 22316170; 26238291;
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to EDN1 promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of EDN1 mRNA	21569818
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EDN1 mRNA	18457675
D019207	beta Carotene	[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA	24657404
D001629	Bezafibrate	Bezafibrate results in decreased expression of EDN1 protein	11330878
D001629	Bezafibrate	Bezafibrate inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]	12967931
D001629	Bezafibrate	Bezafibrate inhibits the reaction [EDN1 protein results in increased activity of RELA protein]	18660453
D001629	Bezafibrate	Bezafibrate inhibits the reaction [EDN1 protein results in increased expression of IL18 mRNA]	18660453
D001663	Bilirubin	Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]	27297870
D001663	Bilirubin	Bilirubin inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]	27297870
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone affects the expression of EDN1 mRNA	30951980
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [EDN1 protein results in increased expression of JUN mRNA]	12169099
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]	12169099
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in decreased expression of EDN1 mRNA	16080914
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in decreased expression of EDN1 protein	16080914
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in decreased expression of EDN1 mRNA	15912405
C006780	bisphenol A	bisphenol A affects the expression of EDN1 mRNA	20170705
C006780	bisphenol A	bisphenol A results in decreased expression of EDN1 mRNA	29275510; 29718440;
C006780	bisphenol A	bisphenol A results in decreased secretion of EDN1 protein	27745655
C006780	bisphenol A	bisphenol A results in decreased expression of EDN1 mRNA	30951980
C006780	bisphenol A	bisphenol A results in decreased expression of EDN1 mRNA	30816183
C006780	bisphenol A	bisphenol A results in increased expression of EDN1 mRNA	25181051
C000611646	bisphenol F	bisphenol F affects the expression of EDN1 mRNA	30951980
D001761	Bleomycin	Bleomycin results in increased expression of EDN1 mRNA	26093215
D001761	Bleomycin	Phytochemicals inhibits the reaction [Bleomycin results in increased expression of EDN1 mRNA]	26093215
D000077300	Bosentan	Bosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]	22483689
D000077300	Bosentan	Bosentan inhibits the reaction [Oxotremorine results in increased activity of EDN1 protein]	22796455
D000077300	Bosentan	Bosentan inhibits the reaction [TGFB1 protein results in increased activity of EDN1 protein]	22796455
D000077300	Bosentan	Bosentan results in decreased activity of EDN1 protein	22796455
D000077300	Bosentan	EDN1 protein inhibits the reaction [Bosentan results in decreased expression of CXADR mRNA]	20392896
D000077300	Bosentan	3,5-dibromosalicylic acid inhibits the reaction [Bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]	11093786
D000077300	Bosentan	Bosentan binds to and results in decreased activity of EDN1 protein	10474778
D000077300	Bosentan	Bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]	11093786
D000077300	Bosentan	Bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]	20967148
D000077300	Bosentan	Bosentan results in decreased activity of EDN1 protein	10961375
D000077300	Bosentan	Bosentan results in decreased expression of EDN1 protein	16431896
D000077300	Bosentan	Bosentan results in decreased activity of EDN1 protein	15063187
C083116	BQ 485	BQ 485 inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]	16391241
C083116	BQ 485	[BQ 485 binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]	14736733
C087220	BQ 610	BQ 610 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]	14759557
C086539	BQ 788	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PTK2 protein]	12875994
C086539	BQ 788	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PXN protein]	12875994
C086539	BQ 788	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]	12875994
C086539	BQ 788	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
C086539	BQ 788	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]	12875994
C086539	BQ 788	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP9 protein]	12875994
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin]	12906840
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]	12875994
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]	12875994
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP9 protein]	12875994
C086539	BQ 788	BQ 788 results in decreased activity of EDN1 protein	12906840
C086539	BQ 788	[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased expression of BCL2 protein]	20369390
C086539	BQ 788	[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased localization of NFATC3 protein]	20369390
C086539	BQ 788	BQ 788 results in increased activity of EDN1 protein	16612843
C086539	BQ 788	BQ 788 inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in decreased expression of AQP4 mRNA]	21259319
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in decreased expression of AQP9 mRNA]	21259319
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]	12184995
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]	16380457
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in increased phosphorylation of STAT3 protein]	30670587
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]	14759557
C086539	BQ 788	[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]]	26694894
C027561	butylbenzyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of EDN1 mRNA	31199487
D002104	Cadmium	Cadmium results in increased expression of EDN1 mRNA	21120746
D002104	Cadmium	Cadmium promotes the reaction [EDN1 protein results in increased metabolism of Phosphatidylinositols]	9439784
D002104	Cadmium	Cadmium results in decreased activity of EDN1 protein	8553374
D002104	Cadmium	Cadmium results in increased secretion of EDN1 protein	10993771
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of EDN1 mRNA	18560533
D019256	Cadmium Chloride	TNF affects the reaction [Cadmium Chloride results in increased expression of EDN1 mRNA]	18560533
C040048	caffeic acid	[Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA	16806235
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]	21926265
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]	21926265
D002110	Caffeine	Caffeine results in increased activity of EDN1 protein	1860718
D000001	Calcimycin	[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides	20977430
D000001	Calcimycin	NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]	20977430
D000001	Calcimycin	Polyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]	20977430
D002117	Calcitriol	Calcitriol results in decreased expression of EDN1 mRNA	16002434
D002117	Calcitriol	Calcitriol results in increased expression of EDN1 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of EDN1 mRNA	21592394
D002118	Calcium	EDN1 protein results in increased abundance of Calcium	15537863
D002118	Calcium	EDN1 protein results in increased uptake of Calcium	11572466
D002118	Calcium	EDN1 protein affects the transport of Calcium	9138053
D002118	Calcium	EDN1 protein results in increased transport of and results in increased abundance of Calcium	27226631
D002118	Calcium	Propofol inhibits the reaction [EDN1 protein affects the transport of Calcium]	9138053
D002118	Calcium	EDN1 protein affects the localization of and affects the abundance of Calcium	11425647
D002118	Calcium	EDN1 protein results in increased uptake of Calcium	11425647
D002118	Calcium	Carvedilol inhibits the reaction [EDN1 protein results in increased import of and results in increased abundance of Calcium]	14711191
D002118	Calcium	EDN1 protein affects the abundance of and affects the localization of Calcium	12821678
D002118	Calcium	EDN1 protein affects the localization of Calcium	12628492
D002118	Calcium	EDN1 protein results in increased abundance of Calcium	1443220
D002118	Calcium	EDN1 protein results in increased import of and results in increased abundance of Calcium	14711191
D002118	Calcium	Glucose affects the reaction [EDN1 protein affects the abundance of and affects the localization of Calcium]	12821678
D002118	Calcium	Heparin inhibits the reaction [EDN1 protein results in increased abundance of Calcium]	1443220
D002118	Calcium	Calcium affects the activity of EDN1 protein	9352311
D002118	Calcium	EDN1 protein promotes the reaction [Capsaicin results in increased abundance of Calcium]	19429182
D002118	Calcium	EDN1 protein results in increased abundance of Calcium	9430702
D002121	Calcium Channel Blockers	Calcium Channel Blockers results in decreased susceptibility to EDN1 protein alternative form	9605596
C058819	calphostin C	calphostin C results in decreased activity of EDN1 protein	15464066
C077793	candesartan cilexetil	candesartan cilexetil inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA]	9853001
D002211	Capsaicin	Capsaicin results in decreased activity of EDN1 protein	7507780
D002211	Capsaicin	Capsaicin inhibits the reaction [Dietary Fats results in increased expression of EDN1 protein]	30342015
D002211	Capsaicin	EDN1 protein promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]	19429182
D002211	Capsaicin	EDN1 protein results in decreased activity of Capsaicin	9932722
D002211	Capsaicin	FR 139317 inhibits the reaction [EDN1 protein results in decreased activity of Capsaicin]	9932722
D002211	Capsaicin	EDN1 protein promotes the reaction [Capsaicin results in increased abundance of Calcium]	19429182
D002244	Carbon	Carbon analog results in decreased activity of EDN1 protein	20214918
D002248	Carbon Monoxide	Carbon Monoxide results in increased expression of EDN1 mRNA	20197249
D002248	Carbon Monoxide	Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]	12969895
D002248	Carbon Monoxide	Carbon Monoxide results in increased expression of EDN1 mRNA	11781074
D002248	Carbon Monoxide	Carbon Monoxide results in increased expression of EDN1 protein	11781074
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of EDN1 mRNA	17484886; 25827057;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of EDN1 protein	25445725
D002251	Carbon Tetrachloride	Lipids inhibits the reaction [Carbon Tetrachloride results in increased expression of EDN1 protein]	25445725
D002251	Carbon Tetrachloride	Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]	18205269
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased activity of EDN1 protein	25858767
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of EDN1 mRNA	17595544
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of EDN1 protein	12575897; 12632514; 12708965;
D002251	Carbon Tetrachloride	EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]	18205269
D002251	Carbon Tetrachloride	IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of EDN1 protein]	12632514
C093373	cariporide	cariporide inhibits the reaction [EDN1 protein results in increased uptake of Sodium]	15681704
C093373	cariporide	cariporide affects the expression of EDN1 mRNA	14749038
D000077261	Carvedilol	Carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	16428915
D000077261	Carvedilol	Carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 protein]	16428915
D000077261	Carvedilol	Carvedilol results in decreased expression of EDN1 mRNA	9500873
D000077261	Carvedilol	Carvedilol results in decreased expression of EDN1 protein	9500873
D000077261	Carvedilol	Carvedilol results in decreased secretion of EDN1 protein	11078433
D000077261	Carvedilol	Carvedilol results in decreased susceptibility to EDN1 protein	18435936
D000077261	Carvedilol	Carvedilol inhibits the reaction [EDN1 protein results in increased import of and results in increased abundance of Calcium]	14711191
D000077261	Carvedilol	Carvedilol results in decreased expression of EDN1 mRNA	18971572
D000077261	Carvedilol	Carvedilol results in decreased expression of EDN1 protein	18840580
D000077261	Carvedilol	Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]	18840580
D002392	Catechin	Catechin inhibits the reaction [APOE gene mutant form results in increased expression of EDN1 protein]	20093625
D002392	Catechin	[Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA	16806235
D002392	Catechin	Catechin inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]	20977430
D002392	Catechin	Catechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	20977430
D002392	Catechin	Catechin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]	20977430
D002392	Catechin	Catechin inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]	20977430
D002392	Catechin	Catechin inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]	20977430
D002395	Catecholamines	EDN1 protein results in increased chemical synthesis of and results in increased abundance of Catecholamines	11911850
C469298	CEP-11004	CEP-11004 inhibits the reaction [EDN1 protein results in increased activity of GATA4 protein]	20067472
C469298	CEP-11004	CEP-11004 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]	20067472
C469298	CEP-11004	CEP-11004 inhibits the reaction [EDN1 protein results in increased secretion of NPPA protein]	20067472
C469298	CEP-11004	CEP-11004 inhibits the reaction [EDN1 protein results in increased secretion of NPPB protein]	20067472
C469298	CEP-11004	CEP-11004 results in decreased susceptibility to EDN1 protein	20067472
C028019	cesium chloride	cesium chloride inhibits the reaction [Acrolein results in increased expression of EDN1 protein]	22928487
C087223	CGP 48369	CGP 48369 results in increased activity of EDN1 protein	7528292
C511403	CGS 35601	CGS 35601 affects the expression of EDN1 protein	16364833
C016299	chelerythrine	chelerythrine inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]	18436224
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased expression of EDN1 mRNA	16357303
C001598	chetomin	chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]	21926265
C001598	chetomin	chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]	21926265
D002713	Chlorine	Chlorine results in increased expression of EDN1 protein	16625121
D002791	Cholesterol, Dietary	Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form	15486036
D002791	Cholesterol, Dietary	Cholesterol, Dietary results in increased expression of EDN1 protein	15486036
D002791	Cholesterol, Dietary	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form]]	15486036
D002791	Cholesterol, Dietary	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 protein]]	15486036
D002791	Cholesterol, Dietary	Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form]	15486036
D002791	Cholesterol, Dietary	Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 protein]	15486036
D002794	Choline	Choline results in increased expression of EDN1 protein	27567547
D002794	Choline	ursolic acid inhibits the reaction [Choline results in increased expression of EDN1 protein]	27567547
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of EDN1 mRNA	28472532
C427471	chromium mesoporphyrin	chromium mesoporphyrin inhibits the reaction [heme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]]	23089228
C427471	chromium mesoporphyrin	chromium mesoporphyrin promotes the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]	23089228
C427471	chromium mesoporphyrin	chromium mesoporphyrin results in increased expression of EDN1 protein	12969895
C427471	chromium mesoporphyrin	Oxygen deficiency promotes the reaction [chromium mesoporphyrin results in increased expression of EDN1 protein]	12969895
C043561	chrysin	chrysin results in increased expression of EDN1 mRNA	18457675
C043867	cicaprost	cicaprost results in decreased expression of EDN1 protein	12391278
D002945	Cisplatin	Cisplatin results in increased expression of EDN1 mRNA	21674241
D002945	Cisplatin	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 results in decreased susceptibility to Cisplatin]	21656314
D002945	Cisplatin	EDN1 results in decreased susceptibility to Cisplatin	21656314
D002945	Cisplatin	Cisplatin results in decreased expression of EDN1 mRNA	22023808
D002945	Cisplatin	Cisplatin results in increased secretion of EDN1 protein	28902463
D002945	Cisplatin	montelukast inhibits the reaction [Cisplatin results in increased secretion of EDN1 protein]	28902463
D002994	Clofibrate	Clofibrate inhibits the reaction [Desoxycorticosterone results in increased expression of EDN1 protein]	16054168
D002994	Clofibrate	Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]	17105827
D002994	Clofibrate	Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein]	17105827
D002994	Clofibrate	Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein]	17105827
D002994	Clofibrate	Clofibrate results in decreased expression of EDN1 protein	17105827
D002994	Clofibrate	Nitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]	17105827
C488583	Clostridium difficile lethal toxin B	Clostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of MAP2K1 protein]	11158304
C488583	Clostridium difficile lethal toxin B	Clostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of MAP2K2 protein]	11158304
C488583	Clostridium difficile lethal toxin B	Clostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]	11158304
C488583	Clostridium difficile lethal toxin B	Clostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]	11158304
C488583	Clostridium difficile lethal toxin B	Clostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of RAF1 protein]	11158304
D003033	Coal Tar	Coal Tar results in increased expression of EDN1 mRNA	27858113
C018021	cobaltous chloride	8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]	29165873
C018021	cobaltous chloride	8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]	29165873
C018021	cobaltous chloride	andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]	27297870; 29165873;
C018021	cobaltous chloride	andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]	29165873
C018021	cobaltous chloride	Bilirubin inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]	27297870
C018021	cobaltous chloride	Bilirubin inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]	27297870
C018021	cobaltous chloride	cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]	10939628
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of EDN1 mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in increased expression of EDN1 mRNA	10939628; 25469848; 27297870; 29165873;
C018021	cobaltous chloride	cobaltous chloride results in increased expression of EDN1 protein	25469848; 29165873;
C018021	cobaltous chloride	cobaltous chloride results in increased secretion of EDN1 protein	27297870
C018021	cobaltous chloride	Genistein affects the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]	10939628
C018021	cobaltous chloride	Genistein inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]	10939628
C018021	cobaltous chloride	SB 203580 inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]	27297870
C018021	cobaltous chloride	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]	27297870; 29165873;
C018021	cobaltous chloride	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]	29165873
C018021	cobaltous chloride	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]	27297870
C018021	cobaltous chloride	Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]]	29165873
C018021	cobaltous chloride	Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]]	29165873
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of EDN1 mRNA	15948191
C018021	cobaltous chloride	cobaltous chloride results in increased expression of EDN1 mRNA	11078357; 11078377; 25469848;
C018021	cobaltous chloride	cobaltous chloride results in increased expression of EDN1 protein	25469848
D003042	Cocaine	Cocaine results in increased expression of EDN1 protein	11948058; 18813882; 9714087;
D003042	Cocaine	Cocaine results in increased secretion of EDN1 protein	17578707
D003042	Cocaine	Cocaine results in increased expression of EDN1 protein	17420087
D003042	Cocaine	1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]	9714087
D003042	Cocaine	Cocaine results in increased expression of EDN1 protein	9714087
D003042	Cocaine	Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]	9714087
C024989	coenzyme Q10	coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]	23640862
C024989	coenzyme Q10	coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]	23640862
C024989	coenzyme Q10	coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein]	23640862
D005576	Colforsin	Colforsin inhibits the reaction [EDN1 protein results in increased expression of CALCRL mRNA]	25194819
D005576	Colforsin	Colforsin inhibits the reaction [EDN1 protein results in increased expression of ICAM2 mRNA]	25194819
D003287	Contrast Media	Contrast Media results in increased expression of EDN1	7967349
D003300	Copper	Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein]	20302851
D019327	Copper Sulfate	Copper Sulfate results in increased expression of EDN1 mRNA	19549813
D003345	Corticosterone	EDN1 results in increased secretion of Corticosterone	1659878
D003375	Coumestrol	[Coumestrol co-treated with Resveratrol] results in decreased expression of EDN1 mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of EDN1 mRNA	19167446
D006152	Cyclic GMP	EDN1 protein results in increased abundance of Cyclic GMP	12972712
D006152	Cyclic GMP	Puromycin Aminonucleoside inhibits the reaction [EDN1 protein results in increased abundance of Cyclic GMP]	12972712
D003513	Cycloheximide	[Cycloheximide co-treated with EDN1 protein] results in increased expression of ADRB2 mRNA	22483689
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of EDN1 protein	17562616; 18548196;
D016572	Cyclosporine	Cyclosporine results in decreased expression of EDN1 mRNA	27989131
D016572	Cyclosporine	Cyclosporine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]	11435416
D016572	Cyclosporine	Cyclosporine results in increased secretion of EDN1 protein	16391421
D016572	Cyclosporine	Cyclosporine results in increased expression of EDN1	7967349
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PTK2 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PXN protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP9 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased expression of BCL2 protein]	20369390
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased localization of NFATC3 protein]	20369390
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin]	12906840
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP9 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 results in decreased susceptibility to Cisplatin]	21656314
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) promotes the reaction [Oxygen deficiency results in increased secretion of EDN1 protein]	24557580
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) results in decreased activity of EDN1 protein	12906840
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) results in increased secretion of EDN1 protein	24557580
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of EDN1 mRNA]	19150882
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]	12839867
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]	12839867
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of EDN1 mRNA]	25230003
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	EDN1 protein affects the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [AGT protein results in increased expression of COL1A1 protein]]	17391658
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) affects the activity of EDN1 protein	16612843
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	3,5-dibromosalicylic acid inhibits the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]]	11093786
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) affects the reaction [Ethanol affects the activity of EDN1 protein]	16651399
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]]	26694894
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]	11093786
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased activity of TH protein]	11911850
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]	11911850
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of GJA1 protein]	15685554
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of TH mRNA]	11911850
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased metabolism of Phosphatidylinositols]	9439784
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]	14736733
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) results in decreased activity of EDN1 protein	9352311
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of EDN1 mRNA	24921660
C077420	Cys(11)-Cys(15)-endothelin-1 (11-21)	Cys(11)-Cys(15)-endothelin-1 (11-21) inhibits the reaction [EDN1 protein results in increased expression of GJA1 protein]	15685554
D003561	Cytarabine	EDN1 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Cytarabine]	24184161
D003561	Cytarabine	EDN1 mutant form affects the reaction [VEGFC protein results in decreased susceptibility to Cytarabine]	24184161
D003609	Dactinomycin	Dactinomycin inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]	22483689
D003620	Dantrolene	Dantrolene results in decreased activity of EDN1 protein	12628492
D003622	Dapsone	Dapsone inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]	21765237
D003630	Daunorubicin	Daunorubicin results in increased expression of EDN1 protein	20888384
D003630	Daunorubicin	Telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein]	20888384
D003676	Deferoxamine	Deferoxamine results in increased expression of EDN1 protein	9357851
D003687	Dehydroepiandrosterone	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased secretion of EDN1 protein]	16373398
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in increased secretion of EDN1 protein	16373398
D003900	Desoxycorticosterone	Clofibrate inhibits the reaction [Desoxycorticosterone results in increased expression of EDN1 protein]	16054168
D003900	Desoxycorticosterone	Desoxycorticosterone results in increased expression of EDN1	12600921
D003900	Desoxycorticosterone	Desoxycorticosterone results in increased expression of EDN1 protein	16054168
D003900	Desoxycorticosterone	Mibefradil inhibits the reaction [[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA]	8934362
D003900	Desoxycorticosterone	[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA	8934362
D003900	Desoxycorticosterone	[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 protein	1860718
D003900	Desoxycorticosterone	[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of EDN1	22431579
D003900	Desoxycorticosterone	Desoxycorticosterone results in increased expression of EDN1	15834289
D064791	Desoxycorticosterone Acetate	chromium mesoporphyrin inhibits the reaction [heme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]]	23089228
D064791	Desoxycorticosterone Acetate	chromium mesoporphyrin promotes the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]	23089228
D064791	Desoxycorticosterone Acetate	[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in increased expression of EDN1 protein	7721389
D064791	Desoxycorticosterone Acetate	Desoxycorticosterone Acetate results in increased expression of EDN1 protein	23089228
D064791	Desoxycorticosterone Acetate	heme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]	23089228
D003907	Dexamethasone	Dexamethasone results in decreased expression of EDN1 mRNA	12206003
D003907	Dexamethasone	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of EDN1 mRNA	16054899
D003907	Dexamethasone	Dexamethasone inhibits the reaction [nitrofen results in decreased expression of EDN1 mRNA]	12407540
D003907	Dexamethasone	Dexamethasone inhibits the reaction [nitrofen results in decreased expression of EDN1 protein]	12407540
D003907	Dexamethasone	Dexamethasone results in increased expression of EDN1 mRNA	22733784
D016264	Dextran Sulfate	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of EDN1 mRNA	29950665
C041517	dibenzo(a,l)pyrene	dibenzo(a,l)pyrene results in decreased expression of EDN1 mRNA	31255691
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of EDN1 mRNA	17361019; 21266533;
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of EDN1 mRNA	21266533
D003993	Dibutyl Phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of EDN1 mRNA	31199487
D004008	Diclofenac	Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium]	15083534
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in decreased susceptibility to EDN1 protein	23872130
D004040	Dietary Carbohydrates	Resveratrol inhibits the reaction [Dietary Carbohydrates results in decreased susceptibility to EDN1 protein]	23872130
D004041	Dietary Fats	Capsaicin inhibits the reaction [Dietary Fats results in increased expression of EDN1 protein]	30342015
D004041	Dietary Fats	Dietary Fats results in increased expression of EDN1 protein	30342015
D004041	Dietary Fats	Simvastatin inhibits the reaction [Dietary Fats results in increased expression of EDN1 protein]	30342015
D004041	Dietary Fats	Dietary Fats results in increased expression of EDN1 mRNA	25016146
D004041	Dietary Fats	[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in increased expression of EDN1 mRNA	19891982
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate affects the expression of EDN1 mRNA	20920545
D004051	Diethylhexyl Phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of EDN1 mRNA	31199487
D004052	Diethylnitrosamine	Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein]	20302851
D004052	Diethylnitrosamine	[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein	20302851
C007379	diethyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of EDN1 mRNA	31199487
C025605	diisobutyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of EDN1 mRNA	31199487
C012125	diisononyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of EDN1 mRNA	31199487
C472511	dimethylarsinous acid	dimethylarsinous acid results in increased expression of EDN1 mRNA	23876855
D015237	Dinoprost	Dinoprost results in increased expression of EDN1 mRNA	20484870
D015237	Dinoprost	[EDN1 protein co-treated with Arachidonic Acid] results in increased abundance of Dinoprost	18809207
D015237	Dinoprost	EDN1 protein results in increased abundance of Dinoprost	18809207
D015237	Dinoprost	EDN1 results in increased secretion of Dinoprost	7507780
D015232	Dinoprostone	EDN1 results in increased secretion of Dinoprostone	7507780
D015232	Dinoprostone	EDN1 protein results in increased secretion of Dinoprostone	16384872
D015232	Dinoprostone	Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
D015232	Dinoprostone	[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone	21811393
D015232	Dinoprostone	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
D015232	Dinoprostone	[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in decreased chemical synthesis of Dinoprostone	16325014
D004147	Dioxins	Dioxins affects the expression of EDN1 mRNA	20463971
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]	20691780
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]	20691780
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]	17391658
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased oxidation of PTPN11 protein]	16391241
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]	16391241
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	12600921
C031291	diphenyliodonium	diphenyliodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]	16261333
C031291	diphenyliodonium	diphenyliodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]	16261333
C031291	diphenyliodonium	diphenyliodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]	16261333
C516138	dorsomorphin	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
D004317	Doxorubicin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]	17974986
D004317	Doxorubicin	Doxorubicin results in increased activity of EDN1 protein	7665224
D004317	Doxorubicin	Doxorubicin results in increased expression of EDN1 protein	17974986; 7969316;
D004317	Doxorubicin	RTKI cpd inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]	17974986
D004317	Doxorubicin	Doxorubicin results in increased expression of EDN1 mRNA	17974986; 18321777;
D004317	Doxorubicin	Doxorubicin results in increased expression of EDN1 protein	17974986; 18321777;
D004317	Doxorubicin	TLR4 protein affects the reaction [Doxorubicin results in increased expression of EDN1 mRNA]	18321777
D004317	Doxorubicin	TLR4 protein affects the reaction [Doxorubicin results in increased expression of EDN1 protein]	18321777
D004317	Doxorubicin	Doxorubicin results in increased expression of EDN1 mRNA	16766856; 17974986;
D004317	Doxorubicin	Doxorubicin results in increased expression of EDN1 protein	11589785
D004317	Doxorubicin	EDN1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]	14736733
D004317	Doxorubicin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]	14736733
D004317	Doxorubicin	[BQ 485 binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]	14736733
D004317	Doxorubicin	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]	14736733
D004317	Doxorubicin	EDN1 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]	14736733
D004317	Doxorubicin	EDN1 protein inhibits the reaction [Doxorubicin results in increased expression of SOD2 protein]	14736733
D004317	Doxorubicin	EDN1 protein results in decreased susceptibility to Doxorubicin	14736733
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal results in decreased expression of EDN1	16981460
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]	15015294
D004394	Dydrogesterone	Dydrogesterone affects the reaction [Estradiol results in decreased expression of EDN1 protein]	12385860
D004656	Enalapril	Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]	9175058
D015773	Enalaprilat	Enalaprilat results in decreased secretion of EDN1 protein	19079593
D004726	Endosulfan	Endosulfan results in decreased expression of EDN1 mRNA	29391264
C118739	entinostat	entinostat results in increased expression of EDN1 mRNA	26272509
C118739	entinostat	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]	20021702
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of EDN1 mRNA	20021702
D004958	Estradiol	Dydrogesterone affects the reaction [Estradiol results in decreased expression of EDN1 protein]	12385860
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in increased expression of EDN1 mRNA	30165855
D004958	Estradiol	Estradiol promotes the reaction [[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA]	19943105
D004958	Estradiol	Estradiol results in decreased expression of EDN1 mRNA	19167446; 20106945; 21632981;
D004958	Estradiol	Estradiol results in decreased expression of EDN1 protein	12385860
D004958	Estradiol	Estradiol results in increased expression of EDN1 mRNA	19153601; 19943105; 21795739;
D004958	Estradiol	Estradiol results in increased secretion of EDN1 protein	21795739
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased expression of EDN1 mRNA]	21795739
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased secretion of EDN1 protein]	21795739
D004958	Estradiol	Estradiol results in increased expression of EDN1 mRNA	19484750
D000431	Ethanol	Ethanol results in increased expression of EDN1 mRNA	12193144
D000431	Ethanol	cyclo(Trp-Asp-Pro-Val-Leu) affects the reaction [Ethanol affects the activity of EDN1 protein]	16651399
D000431	Ethanol	Ethanol affects the activity of EDN1 protein	16651399
D000431	Ethanol	Ethanol results in increased expression of EDN1 protein	25289771
D000431	Ethanol	nymphayol inhibits the reaction [Ethanol results in increased expression of EDN1 protein]	25289771
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of EDN1 mRNA	20170705; 26865667;
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of EDN1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of EDN1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EDN1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of EDN1 mRNA	23129252
D005047	Etoposide	EDN1 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide]	24184161
C063007	exoenzyme C3, Clostridium botulinum	exoenzyme C3, Clostridium botulinum results in decreased expression of EDN1 mRNA	11009568
D005277	Fenfluramine	Fenfluramine results in increased activity of EDN1 protein	9918753
D011345	Fenofibrate	Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of EDN1 mRNA]	31016362
D011345	Fenofibrate	EDN1 protein promotes the reaction [Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]]	22198280
D011345	Fenofibrate	Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]	22198280
D011345	Fenofibrate	Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to NPPB promoter]]	22198280
D011345	Fenofibrate	Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]	22198280
D011345	Fenofibrate	PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]]	22198280
D011345	Fenofibrate	PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]]	22198280
D017313	Fenretinide	Fenretinide results in increased expression of EDN1 mRNA	28973697
C025314	ferric citrate	ferric citrate results in decreased expression of EDN1 mRNA	29959986
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of EDN1 mRNA	28329830
D005472	Fluorouracil	Fluorouracil results in increased expression of EDN1 mRNA	19098008
D005472	Fluorouracil	Fluorouracil results in increased expression of EDN1 protein	1606078
D005557	Formaldehyde	Formaldehyde results in decreased expression of EDN1 mRNA	27664576
D005557	Formaldehyde	Formaldehyde results in increased expression of EDN1 mRNA	17938736
C079574	FR 139317	FR 139317 inhibits the reaction [EDN1 protein results in decreased activity of Capsaicin]	9932722
C079574	FR 139317	FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]	9175058
C505241	FR 180204	FR 180204 inhibits the reaction [EDN1 protein results in increased phosphorylation of STAT3 protein]	30670587
D005632	Fructose	Fructose results in increased expression of EDN1 mRNA	11172478; 14568997; 9869011;
D005632	Fructose	Fructose results in increased expression of EDN1 protein modified form	25108154
D005632	Fructose	Fructose results in increased susceptibility to EDN1 protein	9869011
D005632	Fructose	KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]	14568997
D005632	Fructose	Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]	25108154
D005632	Fructose	Resveratrol inhibits the reaction [Fructose results in increased expression of EDN1 protein]	25108154
D000077267	Fulvestrant	[Fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDN1 mRNA	19943105
C039281	furan	furan results in increased expression of EDN1 mRNA	27387713
C001277	geldanamycin	geldanamycin results in increased expression of EDN1 mRNA	26705709
C056507	gemcitabine	gemcitabine results in decreased expression of EDN1 protein	20531411
D019833	Genistein	Genistein affects the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]	10939628
D019833	Genistein	Genistein affects the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]	10939628
D019833	Genistein	Genistein inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]	10939628
D019833	Genistein	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]	10939628
D019833	Genistein	Genistein results in decreased expression of EDN1 mRNA	26865667
D019833	Genistein	Genistein results in increased methylation of EDN1 gene	28505145
D005839	Gentamicins	Gentamicins results in increased expression of EDN1 protein	10607017; 8160791;
C031049	geranylgeranylacetone	geranylgeranylacetone results in decreased expression of EDN1 protein	16324314
C002963	geranylgeranyl pyrophosphate	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]	11009568
D005947	Glucose	Carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	16428915
D005947	Glucose	Carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 protein]	16428915
D005947	Glucose	CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]	20691780
D005947	Glucose	CEBPA protein affects the reaction [Glucose results in increased expression of and results in increased secretion of EDN1 protein]	24376792
D005947	Glucose	CEBPA protein affects the reaction [Glucose results in increased expression of EDN1 mRNA]	24376792
D005947	Glucose	CEBPB protein affects the reaction [Glucose results in increased expression of and results in increased secretion of EDN1 protein]	24376792
D005947	Glucose	CEBPB protein affects the reaction [Glucose results in increased expression of EDN1 mRNA]	24376792
D005947	Glucose	CEBPD protein affects the reaction [Glucose results in increased expression of and results in increased secretion of EDN1 protein]	24376792
D005947	Glucose	CEBPD protein affects the reaction [Glucose results in increased expression of EDN1 mRNA]	24376792
D005947	Glucose	diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]	20691780
D005947	Glucose	Glucose promotes the reaction [CEBPA protein binds to EDN1 promoter]	24376792
D005947	Glucose	Glucose promotes the reaction [CEBPB protein binds to EDN1 promoter]	24376792
D005947	Glucose	Glucose promotes the reaction [CEBPD protein binds to EDN1 promoter]	24376792
D005947	Glucose	Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]	20691780
D005947	Glucose	Glucose results in increased expression of EDN1 mRNA	16428915; 20960276; 24376792;
D005947	Glucose	Glucose results in increased expression of EDN1 protein	16428915; 24376792;
D005947	Glucose	pyrazolanthrone inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	24376792
D005947	Glucose	Resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	20960276
D005947	Glucose	SB 203580 inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	24376792
D005947	Glucose	U 0126 inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	24376792
D005947	Glucose	Glucose affects the reaction [EDN1 protein affects the abundance of and affects the localization of Calcium]	12821678
D005947	Glucose	Glucose results in increased expression of EDN1 protein	26891083
D005947	Glucose	HIF1A protein affects the reaction [Glucose results in increased expression of EDN1 protein]	26891083
D005947	Glucose	MIR217 mRNA affects the reaction [Glucose results in increased expression of EDN1 protein]	26891083
D005947	Glucose	Resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]	26891083
D005947	Glucose	SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]]	26891083
D005905	Glyburide	Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]]	27890915
D005905	Glyburide	Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]]	27890915
D005905	Glyburide	Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]	18840580
C004312	glycidol	glycidol results in decreased expression of EDN1 mRNA	24915197
C024033	glycoursodeoxycholic acid	glycoursodeoxycholic acid results in decreased expression of EDN1 protein	15556138
C465546	green tea extract AR25	green tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]	17235729
C465546	green tea extract AR25	green tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 protein]	17235729
C412815	GW 4064	GW 4064 results in decreased expression of EDN1 mRNA	16357303
D006220	Haloperidol	Haloperidol results in decreased expression of EDN1 mRNA	29458080
D006220	Haloperidol	Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]	9714087
C048849	heme arginate	chromium mesoporphyrin inhibits the reaction [heme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]]	23089228
C048849	heme arginate	heme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]	23089228
D006493	Heparin	Heparin inhibits the reaction [F2 protein results in increased expression of EDN1 mRNA]	8408661
D006493	Heparin	Heparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein]	7509996; 8408661;
D006493	Heparin	Heparin results in decreased expression of EDN1 mRNA	7509996; 8408661;
D006493	Heparin	Heparin results in decreased secretion of EDN1 protein	7509996; 8408661;
D006493	Heparin	Heparin inhibits the reaction [EDN1 protein results in increased abundance of Calcium]	1443220
D006493	Heparin	Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]	1443220
D006632	Histamine	EDN1 protein results in decreased activity of [Atropine co-treated with Histamine]	12906840
D006710	Homocysteine	Homocysteine affects the expression of EDN1 protein	16757814
D006710	Homocysteine	Zeranol inhibits the reaction [Homocysteine affects the expression of EDN1 protein]	16757814
D006830	Hydralazine	Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]	16326922
D006830	Hydralazine	Hydralazine inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	15302986
D006830	Hydralazine	Hydralazine inhibits the reaction [EDN1 protein results in increased abundance of Thiobarbituric Acid Reactive Substances]	15302986
D006851	Hydrochloric Acid	Hydrochloric Acid results in increased expression of EDN1 protein	19262391
D006852	Hydrochlorothiazide	Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]	16326922
D006861	Hydrogen Peroxide	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]	14623829
D006861	Hydrogen Peroxide	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]	14623829
D006861	Hydrogen Peroxide	epigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]	20021702
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of EDN1 mRNA	20044591; 23410634;
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of EDN1 mRNA	11755377; 12414654; 14623829; 18234130; 20021702;
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of EDN1 protein	11755377
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased secretion of EDN1 protein	14623829; 20021702;
D006861	Hydrogen Peroxide	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]	20021702
D006861	Hydrogen Peroxide	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein]	11755377
D006861	Hydrogen Peroxide	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]	20021702
D006861	Hydrogen Peroxide	Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]	11755377; 14623829; 18234130; 20021702;
D006861	Hydrogen Peroxide	Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein]	11755377
D006861	Hydrogen Peroxide	Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]	14623829; 20021702;
D006861	Hydrogen Peroxide	CAT protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of EDN1 protein]	9357851
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of EDN1 protein	9357851
C031927	hydroquinone	hydroquinone results in decreased expression of EDN1 mRNA	31256213
C492448	ICG 001	ICG 001 results in increased expression of EDN1 mRNA	26191083
C026777	ICI 118551	ICI 118551 inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]	22796455
C568452	importazole	importazole inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]	28942281
C568452	importazole	importazole inhibits the reaction [EDN1 protein results in increased expression of NPPB protein]	28942281
C540383	INCB018424	INCB018424 results in decreased phosphorylation of EDN1 protein	30670587
D007213	Indomethacin	Indomethacin inhibits the reaction [EDN1 protein results in increased secretion of 6-Ketoprostaglandin F1 alpha]	12056553
D007213	Indomethacin	BQ 788 inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin]	12906840
D007213	Indomethacin	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin]	12906840
D007213	Indomethacin	EDN1 protein results in decreased activity of Indomethacin	12906840
D007213	Indomethacin	Indomethacin results in decreased secretion of EDN1 protein	16133044
D007213	Indomethacin	Indomethacin results in increased expression of EDN1 mRNA	16984733
D007213	Indomethacin	Indomethacin affects the activity of EDN1 protein	16612843; 17552879;
D007213	Indomethacin	EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]	16280098
D007213	Indomethacin	EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]]	16280098
D007213	Indomethacin	EDN1 protein promotes the reaction [Indomethacin results in increased expression of LEP protein]	16280098
D007213	Indomethacin	Indomethacin results in increased expression of EDN1 protein	10423059; 11145282; 16280098;
D007213	Indomethacin	phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]	11145282; 16280098;
D007213	Indomethacin	Sucralfate inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]	10423059
D007213	Indomethacin	Indomethacin results in decreased activity of EDN1 protein	7507780
D015544	Inositol 1,4,5-Trisphosphate	CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]	20691780
D015544	Inositol 1,4,5-Trisphosphate	diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]	20691780
D015544	Inositol 1,4,5-Trisphosphate	diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]	20691780
D015544	Inositol 1,4,5-Trisphosphate	EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate	20691780
D015544	Inositol 1,4,5-Trisphosphate	Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]	20691780
D015544	Inositol 1,4,5-Trisphosphate	Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]	20691780
D015544	Inositol 1,4,5-Trisphosphate	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]	11911850
D015544	Inositol 1,4,5-Trisphosphate	EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate	1443220
D015544	Inositol 1,4,5-Trisphosphate	EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate	11911850
D015544	Inositol 1,4,5-Trisphosphate	Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]	1443220
D007295	Inositol Phosphates	EDN1 protein results in increased chemical synthesis of Inositol Phosphates	11572466
C044834	iodixanol	iodixanol results in increased expression of EDN1 protein	21354280
C038192	iopromide	iopromide results in increased expression of EDN1 protein	21354280
C541795	IPA-3 compound	IPA-3 compound inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]	28942281
C541795	IPA-3 compound	IPA-3 compound inhibits the reaction [EDN1 protein results in increased expression of NPPB protein]	28942281
D000077405	Irbesartan	EDN1 gene polymorphism affects the susceptibility to Irbesartan	15188945
D007501	Iron	Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein]	20302851
D007501	Iron	[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein	20302851
D007545	Isoproterenol	Cyclosporine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]	11435416
D007545	Isoproterenol	Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]]	27890915
D007545	Isoproterenol	Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]]	27890915
D007545	Isoproterenol	Isoproterenol results in increased activity of EDN1 promoter	11435416
D007545	Isoproterenol	Isoproterenol results in increased expression of EDN1 mRNA	27890915
D007545	Isoproterenol	Isoproterenol results in increased expression of EDN1 protein	27174236; 27890915; 9861301;
D007545	Isoproterenol	N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]	27890915
D007545	Isoproterenol	N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]	27890915
D007545	Isoproterenol	natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]	27890915
D007545	Isoproterenol	natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]	27174236; 27890915;
D007545	Isoproterenol	Nifedipine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]	11435416
D007545	Isoproterenol	Isoproterenol results in increased secretion of EDN1 protein	10993771
D007548	Isosorbide Dinitrate	[Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA	15719745
D007559	Ivermectin	Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]	28942281
D007559	Ivermectin	Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein]	28942281
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of EDN1 mRNA	24796395
C063302	KN 62	KN 62 inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C073601	KT 5823	KT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]	12184995
C073601	KT 5823	KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]	16389725
C073601	KT 5823	KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]	16389725
D019259	Lamivudine	coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]	23640862
D019259	Lamivudine	Lamivudine results in increased secretion of EDN1 protein	23640862
C029891	lead chloride	lead chloride results in increased secretion of EDN1 protein	15915659
D000077339	Leflunomide	Leflunomide results in increased expression of EDN1 mRNA	19751817
D002955	Leucovorin	Leucovorin results in increased expression of EDN1 mRNA	16925845
D002955	Leucovorin	Leucovorin results in increased expression of EDN1 protein	16925845
D017997	Leukotriene C4	Leukotriene C4 results in increased expression of EDN1 mRNA	11372388
D017997	Leukotriene C4	Leukotriene C4 results in increased expression of EDN1 protein	11372388
D017997	Leukotriene C4	zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 mRNA]	11372388
D017997	Leukotriene C4	zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 protein]	11372388
D007978	Levamisole	Levamisole results in decreased expression of EDN1 mRNA	11139434
C533894	LG 100815	LG 100815 results in increased expression of EDN1 mRNA	16951191
C010210	lignoceric acid	lignoceric acid results in increased expression of EDN1 protein	16895544
C018584	linalool	linalool results in increased expression of EDN1 mRNA	19922762
D019787	Linoleic Acid	Linoleic Acid results in decreased expression of EDN1 mRNA	16895544
D019787	Linoleic Acid	Linoleic Acid results in decreased expression of EDN1 protein	16895544
D008055	Lipids	Lipids inhibits the reaction [Carbon Tetrachloride results in increased expression of EDN1 protein]	25445725
C433788	lipopolysaccharide, E. coli O26-B6	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of EDN1 mRNA]	25230003
C433788	lipopolysaccharide, E. coli O26-B6	lipopolysaccharide, E. coli O26-B6 results in increased expression of EDN1 mRNA	25230003
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of EDN1 mRNA	21355878
D008070	Lipopolysaccharides	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of EDN1 protein]	26694894
D008070	Lipopolysaccharides	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 mRNA]	26694894
D008070	Lipopolysaccharides	[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]]	26694894
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of and results in increased secretion of EDN1 protein	26694894
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of EDN1 mRNA	26694894
D017706	Lisinopril	Lisinopril results in decreased secretion of EDN1 protein	19079593
D019808	Losartan	Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]	17666345
D019808	Losartan	Losartan results in decreased expression of EDN1 protein	11369837
D019808	Losartan	Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]	12901495
D019808	Losartan	Losartan results in decreased expression of EDN1 mRNA	16191423; 18971572;
D019808	Losartan	Losartan results in decreased expression of EDN1 protein	16191423
C025340	manganese chloride	manganese chloride results in decreased expression of EDN1 mRNA	28801915
D008558	Melphalan	Melphalan results in increased expression of EDN1 protein	18548196
C042720	mercuric bromide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of EDN1 mRNA	20353558
D008627	Mercuric Chloride	candesartan cilexetil inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA]	9853001
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of EDN1 mRNA	9853001
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of EDN1 protein	9788586; 9853001;
D008627	Mercuric Chloride	pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA]	9853001
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]	25108154
D008727	Methotrexate	Methotrexate results in increased expression of EDN1 mRNA	21678067
D008731	Methoxychlor	Methoxychlor results in increased methylation of EDN1 gene	23303685
C108732	methyl-beta-cyclodextrin	methyl-beta-cyclodextrin inhibits the reaction [EDN1 protein affects the localization of CD38 protein]	23940720
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of EDN1 mRNA	28001369
D008775	Methylprednisolone	Methylprednisolone results in decreased expression of EDN1 protein	14688695
D008775	Methylprednisolone	Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]	7756592
D008790	Metoprolol	Metoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA]	11435416
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of EDN1 mRNA alternative form]	9637705
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]	11009568
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA alternative form]	9637705
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]	18390205
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein]	18390205
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form]]	15486036
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 protein]]	15486036
D020748	Mibefradil	Mibefradil inhibits the reaction [[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA]	8934362
D008898	Mimosine	Mimosine results in increased expression of EDN1 mRNA	25469848
D008898	Mimosine	Mimosine results in increased expression of EDN1 protein	25469848
C070571	ML 7	ML 7 results in decreased activity of EDN1 protein	15939040
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of EDN1 mRNA	16809437
D016686	Monocrotaline	4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]	16225752
D016686	Monocrotaline	4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein]	16225752
D016686	Monocrotaline	Bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]	20967148
D016686	Monocrotaline	Monocrotaline results in increased expression of EDN1 mRNA	16225752; 22022327;
D016686	Monocrotaline	Monocrotaline results in increased expression of EDN1 protein	16225752; 20967148;
D016686	Monocrotaline	Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]	22022327
C093875	montelukast	montelukast inhibits the reaction [Cisplatin results in increased secretion of EDN1 protein]	28902463
D009151	Mustard Gas	Mustard Gas results in increased expression of EDN1 mRNA	25102026
C502260	N-(1-methylethyl)-1,1,2-trimethylpropylamine	N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]	27890915
C502260	N-(1-methylethyl)-1,1,2-trimethylpropylamine	N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]	27890915
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]	14759557
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide affects the reaction [PTPN11 protein affects the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]]	16261333
C071595	N(6)-benzyl-cyclic adenosine 5'-monophosphate	N(6)-benzyl-cyclic adenosine 5'-monophosphate inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]	22796455
C071595	N(6)-benzyl-cyclic adenosine 5'-monophosphate	N(6)-benzyl-cyclic adenosine 5'-monophosphate inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA]	22796455
C024376	NAADP	EDN1 protein results in increased metabolism of NAADP	23940720
C024376	NAADP	NOX1 mutant form inhibits the reaction [EDN1 protein results in increased metabolism of NAADP]	23940720
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of EDN1 mRNA	25102311
D037742	Nanotubes, Carbon	Nanotubes, Carbon affects the expression of EDN1 mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of EDN1 mRNA	25554681
C031721	naphthalene	naphthalene results in increased expression of EDN1 mRNA	18978301
C556401	natakalim	Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]]	27890915
C556401	natakalim	Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]]	27890915
C556401	natakalim	natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]	27890915
C556401	natakalim	natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]	27174236; 27890915;
C556401	natakalim	natakalim inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]	22860425
C556401	natakalim	natakalim results in decreased expression of EDN1 protein	25215478
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of EDN1 mRNA	19812364
D000068577	Nebivolol	Nebivolol results in decreased expression of EDN1 mRNA	11078433
D000068577	Nebivolol	Nebivolol results in decreased secretion of EDN1 protein	11078433
D000068577	Nebivolol	Nebivolol results in decreased susceptibility to EDN1 protein	18435936
D009532	Nickel	Nickel results in decreased expression of EDN1 mRNA	25583101
D009532	Nickel	Nickel affects the activity of EDN1 protein	9352311
C029938	nickel sulfate	nickel sulfate results in increased expression of EDN1 mRNA	22714537
D009538	Nicotine	Nicotine affects the expression of EDN1	19637760
D009543	Nifedipine	Nifedipine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]	11435416
D009543	Nifedipine	Nifedipine results in decreased activity of EDN1 protein	12628492
D009543	Nifedipine	Nifedipine results in increased activity of EDN1 protein	7528292
C012655	nimesulide	nimesulide results in increased activity of EDN1 protein	16612843
C012655	nimesulide	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]	21811393
C012655	nimesulide	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
C012655	nimesulide	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]	21811393
D015737	Nisoldipine	Nisoldipine results in decreased expression of EDN1 protein	8742913
D009569	Nitric Oxide	EDN1 protein results in increased chemical synthesis of Nitric Oxide	11187978
D009569	Nitric Oxide	Nitric Oxide results in decreased expression of EDN1 protein	15838368
D009569	Nitric Oxide	Nitric Oxide results in increased expression of EDN1 protein	20929026
D009569	Nitric Oxide	Nitric Oxide results in increased expression of EDN1 mRNA	20197249
D009569	Nitric Oxide	Nitric Oxide affects the activity of EDN1 protein	17552879
D009569	Nitric Oxide	[Nitric Oxide co-treated with EDN1 protein] results in increased abundance of Peroxynitrous Acid	11509453
D009569	Nitric Oxide	BQ 788 inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]	16380457
D009569	Nitric Oxide	EDN1 protein results in increased abundance of Nitric Oxide	16380457
D009569	Nitric Oxide	[EDN1 protein results in increased activity of EDNRB protein] which results in increased abundance of Nitric Oxide	16380457
D009569	Nitric Oxide	[EDN1 protein results in increased activity of NOS1 protein] which results in increased abundance of Nitric Oxide	16380457
D009569	Nitric Oxide	Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]	16326922
D009569	Nitric Oxide	Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]	16326922
D009569	Nitric Oxide	Nitric Oxide deficiency results in decreased activity of EDN1 protein	16810074
D009569	Nitric Oxide	Nitric Oxide deficiency results in increased expression of EDN1 mRNA	16326922
D009569	Nitric Oxide	Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]	16389725
D009569	Nitric Oxide	Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]	16389725
D009569	Nitric Oxide	Nitric Oxide results in increased secretion of EDN1 protein	15640287
D009569	Nitric Oxide	S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]	16380457
D009569	Nitric Oxide	EDN1 protein results in increased abundance of Nitric Oxide	12672649
D009569	Nitric Oxide	Nitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]	17105827
D009569	Nitric Oxide	EDN1 protein promotes the reaction [EDNRB protein results in increased chemical synthesis of Nitric Oxide]	10976779
D009569	Nitric Oxide	Nitric Oxide results in decreased expression of EDN1 protein	7828305
D009569	Nitric Oxide	Nitric Oxide results in increased expression of EDN1 protein	11509453
D020030	Nitric Oxide Donors	Nitric Oxide Donors inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]	16389725
D020030	Nitric Oxide Donors	Nitric Oxide Donors inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]	16389725
D020030	Nitric Oxide Donors	Nitric Oxide Donors results in increased secretion of EDN1 protein	15640287
C007350	nitrofen	Dexamethasone inhibits the reaction [nitrofen results in decreased expression of EDN1 mRNA]	12407540
C007350	nitrofen	Dexamethasone inhibits the reaction [nitrofen results in decreased expression of EDN1 protein]	12407540
C007350	nitrofen	nitrofen results in decreased expression of EDN1 mRNA	12407540
C007350	nitrofen	nitrofen results in decreased expression of EDN1 protein	12407540
C007350	nitrofen	nitrofen results in increased expression of EDN1 mRNA	10693666; 15756563; 9473106;
C007350	nitrofen	nitrofen results in increased expression of EDN1 protein	10693666
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of EDN1 mRNA	12206003
D005996	Nitroglycerin	Nitroglycerin results in increased expression of EDN1 protein	7539147
D005996	Nitroglycerin	Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]	12901495
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of EDN1 mRNA	11751199
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of EDN1 protein	11751199
D005996	Nitroglycerin	Nitroglycerin results in increased expression of EDN1 protein	12901495
D009599	Nitroprusside	Nitroprusside inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]	16023617
D009599	Nitroprusside	Nitroprusside inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]	16389725
D009599	Nitroprusside	Nitroprusside inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]	16389725
D009599	Nitroprusside	Nitroprusside results in decreased secretion of EDN1 protein	10993771
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of EDN1 mRNA	17616710
D009638	Norepinephrine	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]	14759557
D009638	Norepinephrine	BQ 610 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]	14759557
D009638	Norepinephrine	BQ 788 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]	12184995
D009638	Norepinephrine	BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]	14759557
D009638	Norepinephrine	[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine	16023617
D009638	Norepinephrine	EDN1 protein results in decreased secretion of Norepinephrine	12184995
D009638	Norepinephrine	EDN1 protein results in increased secretion of Norepinephrine	14759557
D009638	Norepinephrine	KT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]	12184995
D009638	Norepinephrine	Metoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA]	11435416
D009638	Norepinephrine	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]	14759557
D009638	Norepinephrine	Norepinephrine results in increased activity of EDN1 promoter	11435416
D009638	Norepinephrine	Norepinephrine results in increased expression of EDN1 mRNA	11435416
D009638	Norepinephrine	Picrotoxin inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]	12184995
C570897	NSC668394	NSC668394 results in increased expression of EDN1 mRNA	27137931
C558013	NSC 689534	NSC 689534 results in increased expression of EDN1 mRNA	20971185
C482205	nutlin 3	nutlin 3 results in increased expression of EDN1 mRNA	19098008
C482205	nutlin 3	nutlin 3 results in increased expression of EDN1 protein	19098008
C010722	nylestriol	nylestriol results in decreased expression of EDN1 protein	12536650; 12934402;
C000594859	nymphayol	nymphayol inhibits the reaction [Ethanol results in increased expression of EDN1 protein]	25289771
C025589	ochratoxin A	ochratoxin A results in increased expression of EDN1 mRNA	30559759
C062198	octa-2,4,6-trienoic acid	octa-2,4,6-trienoic acid results in increased expression of EDN1 mRNA	16951191
D019301	Oleic Acid	Oleic Acid results in decreased expression of EDN1 mRNA	16895544
D019301	Oleic Acid	Oleic Acid results in decreased expression of EDN1 protein	16895544
C437965	olmesartan	olmesartan inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	15302986
C437965	olmesartan	olmesartan inhibits the reaction [EDN1 protein results in increased abundance of Thiobarbituric Acid Reactive Substances]	15302986
D000068557	Olmesartan Medoxomil	Olmesartan Medoxomil results in decreased expression of EDN1 mRNA	16336959
C549647	olodaterol	2'-O-methyl-8-(4-chlorophenylthio)cAMP inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]	22796455
C549647	olodaterol	EDN1 protein promotes the reaction [olodaterol results in increased expression of ADRB2 mRNA]	22483689
C549647	olodaterol	ICI 118551 inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]	22796455
C549647	olodaterol	N(6)-benzyl-cyclic adenosine 5'-monophosphate inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]	22796455
C549647	olodaterol	olodaterol inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]	22796455
C549647	olodaterol	olodaterol inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA]	22796455
C549647	olodaterol	olodaterol promotes the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]	22483689
C549647	olodaterol	olodaterol results in decreased expression of EDN1 mRNA	22796455
D009963	Orotic Acid	Orotic Acid results in increased expression of EDN1 protein	25601987
D010042	Ouabain	Ouabain results in decreased expression of EDN1 mRNA	28795476
D010042	Ouabain	Ouabain results in increased expression of EDN1 mRNA	15477225
D010095	Oxotremorine	Bosentan inhibits the reaction [Oxotremorine results in increased activity of EDN1 protein]	22796455
D010095	Oxotremorine	olodaterol inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]	22796455
D010095	Oxotremorine	[Oxotremorine co-treated with TGFB1 protein] results in increased expression of EDN1 mRNA	22796455
D010095	Oxotremorine	Oxotremorine results in increased activity of EDN1 protein	22796455
D010095	Oxotremorine	Oxotremorine results in increased expression of EDN1 mRNA	22796455
D010095	Oxotremorine	Tiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]	22796455
D010100	Oxygen	caffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]	21926265
D010100	Oxygen	caffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]	21926265
D010100	Oxygen	chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]	21926265
D010100	Oxygen	chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]	21926265
D010100	Oxygen	cyclo(Trp-Asp-Pro-Val-Leu) promotes the reaction [Oxygen deficiency results in increased secretion of EDN1 protein]	24557580
D010100	Oxygen	EPO protein inhibits the reaction [Oxygen deficiency results in increased secretion of EDN1 protein]	24557580
D010100	Oxygen	Genistein affects the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]	10939628
D010100	Oxygen	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]	10939628
D010100	Oxygen	Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]	10939628
D010100	Oxygen	Oxygen deficiency results in increased expression of EDN1 mRNA	10939628; 14508066; 17968679; 20042640; 25469848;
D010100	Oxygen	Oxygen deficiency results in increased expression of EDN1 protein	18001528; 22363556; 25469848;
D010100	Oxygen	Oxygen deficiency results in increased secretion of EDN1 protein	21926265; 24557580;
D010100	Oxygen	Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]	22363556
D010100	Oxygen	MMP2 protein affects the susceptibility to [EDN1 protein co-treated with Oxygen deficiency]	16980344
D010100	Oxygen	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of EDN1 mRNA	30529165
D010100	Oxygen	Oxygen deficiency results in increased expression of EDN1 mRNA	10939628; 21926265;
D010100	Oxygen	Oxygen deficiency results in increased expression of EDN1 protein	21926265
D010100	Oxygen	Oxygen results in increased expression of EDN1 mRNA	25203536
D010100	Oxygen	Rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]	21926265
D010100	Oxygen	Rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]	21926265
D010100	Oxygen	natakalim inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]	22860425
D010100	Oxygen	Oxygen deficiency promotes the reaction [chromium mesoporphyrin results in increased expression of EDN1 protein]	12969895
D010100	Oxygen	Oxygen deficiency results in increased expression of EDN1 mRNA	22860425; 25469848;
D010100	Oxygen	Oxygen deficiency results in increased expression of EDN1 protein	25469848; 28985491;
D010100	Oxygen	tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]	28985491
D010126	Ozone	Ozone results in increased expression of EDN1 mRNA	27206323
D010126	Ozone	Ozone results in increased expression of EDN1 mRNA	16081523; 16716893; 16741034; 17662977; 20980218;
D010126	Ozone	Ozone results in increased expression of EDN1 protein	16081523; 16741034;
D010126	Ozone	[Particulate Matter co-treated with Ozone] results in increased expression of EDN1 mRNA	16081523
D019308	Palmitic Acid	Palmitic Acid results in increased expression of EDN1 mRNA	16895544
D019308	Palmitic Acid	Palmitic Acid results in increased expression of EDN1 protein	16895544
D000077767	Panobinostat	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
D000077767	Panobinostat	Panobinostat results in increased expression of EDN1 mRNA	26272509
D010269	Paraquat	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]	21765237
D010269	Paraquat	Dapsone inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]	21765237
D010269	Paraquat	Paraquat results in increased expression of EDN1 mRNA	21765237
D010269	Paraquat	green tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]	17235729
D010269	Paraquat	green tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 protein]	17235729
D010269	Paraquat	Paraquat results in increased expression of EDN1 mRNA	17235729
D010269	Paraquat	Paraquat results in increased expression of EDN1 protein	17235729
C084656	paricalcitol	paricalcitol inhibits the reaction [EDN1 protein results in increased expression of NPPA mRNA]	21565836
C084656	paricalcitol	paricalcitol inhibits the reaction [EDN1 protein results in increased expression of PRKCA protein modified form]	21565836
D052638	Particulate Matter	Particulate Matter results in decreased expression of EDN1 mRNA	24769257
D052638	Particulate Matter	Particulate Matter results in increased expression of EDN1 protein	23451061
D052638	Particulate Matter	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased susceptibility to EDN1 protein]	20561571
D052638	Particulate Matter	[Particulate Matter co-treated with Ozone] results in increased expression of EDN1 mRNA	16081523
D052638	Particulate Matter	Particulate Matter results in decreased expression of EDN1 mRNA	12396869
D052638	Particulate Matter	Particulate Matter results in increased expression of EDN1 mRNA	16081523; 16741034; 20025942;
D052638	Particulate Matter	Particulate Matter results in increased expression of EDN1 protein	12396869; 16081523; 16741034; 20025942;
D052638	Particulate Matter	Particulate Matter results in increased susceptibility to EDN1 protein	19535675; 20561571;
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of EDN1 mRNA	18593933
C073402	PD 123319	PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein]	15007106
C076213	PD 142893	PD 142893 inhibits the reaction [EDN1 protein results in decreased secretion of NPY protein]	12234805
C093321	PD 156707	PD 156707 inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	11509453
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of EDN1 mRNA	29458080
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of EDN1 mRNA	23602845
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of EDN1 mRNA	29505797
D030421	Peroxynitrous Acid	[Nitric Oxide co-treated with EDN1 protein] results in increased abundance of Peroxynitrous Acid	11509453
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of EDN1 mRNA	26678675
D010634	Phenobarbital	Phenobarbital results in decreased expression of EDN1 mRNA	19084549
D010656	Phenylephrine	EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]	12724418
D010656	Phenylephrine	EDN1 protein results in increased susceptibility to Phenylephrine	20977430
D010656	Phenylephrine	Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]	10788492
D010656	Phenylephrine	Phenylephrine results in increased expression of EDN1 mRNA	10788492
D010656	Phenylephrine	Phenylephrine results in increased expression of EDN1 protein	15220332
D010656	Phenylephrine	Polyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]	20977430
D010656	Phenylephrine	Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]	15007106
D010656	Phenylephrine	Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]	11739382
D010656	Phenylephrine	ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]	15220332
D010656	Phenylephrine	EDN1 protein results in increased susceptibility to Phenylephrine	19948983
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
D010705	Phosgene	Phosgene results in increased expression of EDN1 protein	18645720
D010716	Phosphatidylinositols	Cadmium promotes the reaction [EDN1 protein results in increased metabolism of Phosphatidylinositols]	9439784
D010716	Phosphatidylinositols	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased metabolism of Phosphatidylinositols]	9439784
D010716	Phosphatidylinositols	EDN1 protein results in increased metabolism of Phosphatidylinositols	9439784
C030090	phosphoramide mustard	phosphoramide mustard results in increased expression of EDN1 mRNA	27888070
C008890	phosphoramidon	EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]	16280098
C008890	phosphoramidon	EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]]	16280098
C008890	phosphoramidon	phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]	11145282; 16280098;
C008890	phosphoramidon	phosphoramidon results in decreased expression of EDN1 protein	16391412
D064209	Phytochemicals	Phytochemicals inhibits the reaction [Bleomycin results in increased expression of EDN1 mRNA]	26093215
D010852	Picrotoxin	Picrotoxin inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]	12184995
C121565	pifithrin	pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]	19098008
C121565	pifithrin	pifithrin results in decreased expression of EDN1 mRNA	19098008
C004479	pimagedine	pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA]	9853001
D000077205	Pioglitazone	Pioglitazone inhibits the reaction [EDN1 protein results in increased activity of RELA protein]	18660453
D000077205	Pioglitazone	Pioglitazone inhibits the reaction [EDN1 protein results in increased expression of IL18 mRNA]	18660453
D000077205	Pioglitazone	Pioglitazone results in decreased secretion of EDN1 protein	9920814
D010936	Plant Extracts	Plant Extracts results in decreased expression of EDN1 mRNA	16680075
D010936	Plant Extracts	Plant Extracts results in increased expression of EDN1 mRNA	20707411
D010938	Plant Oils	Plant Oils results in increased expression of EDN1 mRNA	23370395
D028321	Plant Preparations	[Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA	15719745
D028321	Plant Preparations	Plant Preparations results in decreased susceptibility to EDN1 protein	23872130
D028321	Plant Preparations	Resveratrol inhibits the reaction [Plant Preparations results in decreased susceptibility to EDN1 protein]	23872130
D010972	Platelet Activating Factor	Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]	18205269
D010972	Platelet Activating Factor	EDN1 protein results in increased abundance of Platelet Activating Factor	18205269
D010972	Platelet Activating Factor	EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]	18205269
D010972	Platelet Activating Factor	EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]	18205269
D059808	Polyphenols	Polyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]	20977430
D059808	Polyphenols	Polyphenols inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]	20977430
D059808	Polyphenols	Polyphenols inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]	20977430
D059808	Polyphenols	Polyphenols inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]	20977430
D059808	Polyphenols	Polyphenols inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]	20977430
D059808	Polyphenols	Polyphenols inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]	20977430
D059808	Polyphenols	Polyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]	20977430
D011137	Polystyrenes	Polystyrenes analog results in decreased expression of EDN1 mRNA	25102311
D011137	Polystyrenes	Polystyrenes results in decreased expression of EDN1 mRNA	25102311
D011188	Potassium	Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium]	15083534
D011188	Potassium	EDN1 protein results in decreased transport of Potassium	15083534
D011188	Potassium	Potassium results in increased secretion of EDN1 protein	10993771
D011189	Potassium Chloride	[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA	18823320
D011189	Potassium Chloride	Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]	21811393
D011189	Potassium Chloride	Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
D011189	Potassium Chloride	[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA	21811393
D011189	Potassium Chloride	[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone	21811393
D011189	Potassium Chloride	[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein	21811393
D011189	Potassium Chloride	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]	21811393
D011189	Potassium Chloride	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
D011189	Potassium Chloride	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]	21811393
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of EDN1 mRNA	22714537
D017035	Pravastatin	Pravastatin results in decreased expression of EDN1 protein	12105140
D017035	Pravastatin	Pravastatin results in decreased expression of EDN1 mRNA	19812503
D017035	Pravastatin	Pravastatin results in decreased expression of EDN1 protein	19812503
D011224	Prazosin	Prazosin inhibits the reaction [EDN1 protein results in increased expression of NPPA protein]	12513686
D011224	Prazosin	Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]	15007106
D011374	Progesterone	Arachidonic Acid promotes the reaction [EDN1 protein inhibits the reaction [LHB protein results in increased chemical synthesis of Progesterone]]	18809207
D011374	Progesterone	EDN1 protein inhibits the reaction [LHB protein results in increased abundance of Progesterone]	15537863
D011374	Progesterone	EDN1 protein inhibits the reaction [LHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]	18809207
D011374	Progesterone	EDN1 protein results in decreased abundance of Progesterone	15537863; 16388928;
D011374	Progesterone	Progesterone results in decreased expression of EDN1 mRNA	23012394
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased expression of EDN1 mRNA]	21795739
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased secretion of EDN1 protein]	21795739
D011374	Progesterone	Progesterone results in increased expression of EDN1 mRNA	22238285
D011374	Progesterone	Progesterone results in decreased expression of EDN1 mRNA	20726854
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [EDN1 protein results in increased activity of RELA protein]	18660453
D015742	Propofol	Propofol inhibits the reaction [EDN1 protein affects the transport of Calcium]	9138053
D015742	Propofol	Propofol results in decreased expression of EDN1 protein	17470888
D011441	Propylthiouracil	Propylthiouracil results in increased expression of EDN1 mRNA	25825206
D015230	Prostaglandin D2	EDN1 results in increased secretion of Prostaglandin D2	7507780
D015230	Prostaglandin D2	EDN1 results in increased secretion of Prostaglandin D2 metabolite	7507780
D011692	Puromycin Aminonucleoside	Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]	9175058
D011692	Puromycin Aminonucleoside	FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]	9175058
D011692	Puromycin Aminonucleoside	Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]	7756592
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside inhibits the reaction [EDN1 protein results in increased abundance of Cyclic GMP]	12972712
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of EDN1 mRNA	12972712; 7756592; 9175058;
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	24376792
D011791	Quartz	Quartz results in decreased expression of EDN1 mRNA	27917503
D011794	Quercetin	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]	20021702
D011794	Quercetin	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein]	11755377
D011794	Quercetin	Quercetin inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]	20021702
D011794	Quercetin	Quercetin results in decreased expression of EDN1 mRNA	18234130; 20021702;
D011794	Quercetin	Quercetin results in decreased secretion of EDN1 protein	20021702
D011794	Quercetin	Quercetin results in increased expression of EDN1 mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [APOE gene mutant form results in increased expression of EDN1 protein]	20093625
D011794	Quercetin	Quercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]	18436224
D011794	Quercetin	Quercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]	18436224
D000077583	Quinapril	Quinapril results in decreased expression of EDN1	12149661
D000077583	Quinapril	Quinapril results in decreased expression of EDN1 protein	12425201
D017382	Reactive Oxygen Species	Reactive Oxygen Species results in increased expression of EDN1 protein	11603923
D017382	Reactive Oxygen Species	Reactive Oxygen Species results in increased phosphorylation of and results in increased activity of EDN1 protein	11603923
D017382	Reactive Oxygen Species	acetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]	22431579
D017382	Reactive Oxygen Species	Atrasentan inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]	22431579
D017382	Reactive Oxygen Species	BQ 485 inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]	16391241
D017382	Reactive Oxygen Species	EDN1 protein results in increased abundance of Reactive Oxygen Species	16391241; 22431579;
D017382	Reactive Oxygen Species	EDN1 protein results in increased chemical synthesis of Reactive Oxygen Species	16271043
C087120	RES 701-1	RES 701-1 inhibits the reaction [EDN1 protein results in decreased secretion of NPY protein]	12234805
D000077185	Resveratrol	[Coumestrol co-treated with Resveratrol] results in decreased expression of EDN1 mRNA	19167446
D000077185	Resveratrol	Resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	20960276
D000077185	Resveratrol	Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]	11755377; 14623829; 18234130; 20021702;
D000077185	Resveratrol	Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein]	11755377
D000077185	Resveratrol	Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]	14623829; 20021702;
D000077185	Resveratrol	Resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 mRNA]	25493383
D000077185	Resveratrol	Resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 protein]	25493383
D000077185	Resveratrol	Resveratrol results in decreased expression of EDN1 mRNA	14623829; 18234130; 20021702; 20878097;
D000077185	Resveratrol	Resveratrol results in decreased secretion of EDN1 protein	14623829; 20021702;
D000077185	Resveratrol	[Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA	16806235
D000077185	Resveratrol	Resveratrol results in decreased expression of EDN1 mRNA	22935447
D000077185	Resveratrol	Resveratrol inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]	15878161
D000077185	Resveratrol	Resveratrol inhibits the reaction [Fructose results in increased expression of EDN1 protein]	25108154
D000077185	Resveratrol	Resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]	26891083
D000077185	Resveratrol	Resveratrol results in decreased expression of EDN1	16535856
D000077185	Resveratrol	SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]]	26891083
D000077185	Resveratrol	Resveratrol inhibits the reaction [Dietary Carbohydrates results in decreased susceptibility to EDN1 protein]	23872130
D000077185	Resveratrol	Resveratrol inhibits the reaction [Plant Preparations results in decreased susceptibility to EDN1 protein]	23872130
D000077185	Resveratrol	Resveratrol results in decreased activity of EDN1 protein	21554123
D000077185	Resveratrol	Resveratrol results in decreased susceptibility to EDN1 protein	18656273
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of EDN1 mRNA	21127053
C064758	Ro 31-8220	Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]	12169099
C085989	Ro 32-0432	Ro 32-0432 inhibits the reaction [EDN1 protein results in increased activity of TH protein]	11911850
C085989	Ro 32-0432	Ro 32-0432 inhibits the reaction [EDN1 protein results in increased expression of TH mRNA]	11911850
D020889	Rolipram	Rolipram results in increased activity of EDN1 protein	15464066
D000077154	Rosiglitazone	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of EDN1 mRNA	16054899
D000077154	Rosiglitazone	Rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]	21926265
D000077154	Rosiglitazone	Rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]	21926265
D012402	Rotenone	Rotenone inhibits the reaction [Acrolein results in increased expression of EDN1 protein]	22928487
D012402	Rotenone	Rotenone results in increased expression of and results in increased secretion of EDN1 protein	11707688
D012402	Rotenone	Rotenone results in increased expression of EDN1 mRNA	11078378; 11707688;
C101044	RTKI cpd	RTKI cpd inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]	17974986
C101044	RTKI cpd	RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]]	16261333
C101044	RTKI cpd	RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]]	16261333
C093642	SB 203580	SB 203580 inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]	27297870
C093642	SB 203580	SB 203580 inhibits the reaction [EDN1 protein results in increased expression of CXCL8 mRNA]	18457675
C093642	SB 203580	SB 203580 inhibits the reaction [EDN1 protein results in increased expression of EDN1 mRNA]	18457675; 18457675;
C093642	SB 203580	SB 203580 inhibits the reaction [EDN1 protein results in increased expression of IL6 mRNA]	18457675
C093642	SB 203580	SB 203580 inhibits the reaction [EDN1 protein results in increased expression of PTGS2 mRNA]	18457675
C093642	SB 203580	SB 203580 inhibits the reaction [EDN1 protein results in increased expression of VCAM1 mRNA]	18457675
C093642	SB 203580	SB 203580 inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	24376792
C093642	SB 203580	SB 203580 inhibits the reaction [EDN1 protein results in increased phosphorylation of CREB1 protein]	14741741
C078903	seocalcitol	seocalcitol results in decreased expression of EDN1 mRNA	12040012
D012701	Serotonin	Serotonin results in increased activity of EDN1 protein	9918753
D000077149	Sevoflurane	Sevoflurane affects the expression of EDN1 mRNA	15967596
D000068677	Sildenafil Citrate	Sildenafil Citrate inhibits the reaction [EDN1 protein results in increased expression of TRPC1 mRNA]	18818482
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of EDN1 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of EDN1 mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of EDN1 mRNA	30453980
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of EDN1 mRNA	19073995
D012834	Silver	Silver results in increased expression of EDN1 mRNA	26014281
D019821	Simvastatin	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]	11009568
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]	11009568
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA alternative form]	9637705
D019821	Simvastatin	Simvastatin inhibits the reaction [RHOA results in increased expression of EDN1 mRNA]	11009568
D019821	Simvastatin	Simvastatin results in decreased expression of EDN1 mRNA	11009568; 16375908;
D019821	Simvastatin	Simvastatin results in decreased expression of EDN1 mRNA alternative form	9637705
D019821	Simvastatin	Simvastatin results in decreased expression of EDN1 protein	9637705
D019821	Simvastatin	Simvastatin inhibits the reaction [Dietary Fats results in increased expression of EDN1 protein]	30342015
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]	18390205
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein]	18390205
D019821	Simvastatin	Simvastatin results in decreased expression of EDN1 mRNA	18390205
D019821	Simvastatin	Simvastatin results in decreased expression of EDN1 protein	18390205
D019821	Simvastatin	Simvastatin results in decreased secretion of EDN1 protein	16375908
D019821	Simvastatin	Simvastatin results in increased expression of and results in increased secretion of EDN1 protein	20369390
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form]]	15486036
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 protein]]	15486036
D019821	Simvastatin	Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form]	15486036
D019821	Simvastatin	Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 protein]	15486036
D019821	Simvastatin	Simvastatin inhibits the reaction [EDN1 protein results in increased expression of CLCN3 protein]	20644009
D019821	Simvastatin	Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]	22022327
D019821	Simvastatin	Simvastatin results in decreased expression of EDN1 mRNA	19099753; 21844074;
D020123	Sirolimus	Sirolimus inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]	12411397
D020123	Sirolimus	Sirolimus inhibits the reaction [EDN1 protein results in increased phosphorylation of EIF4EBP1 protein]	12411397
C086717	S-methylthiocitrulline	S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]	16380457
C118258	SN50 peptide	SN50 peptide inhibits the reaction [EDN1 protein results in increased activity of RELA protein]	18660453
D026423	S-Nitroso-N-Acetylpenicillamine	S-Nitroso-N-Acetylpenicillamine results in increased secretion of EDN1 protein	15640287
D026423	S-Nitroso-N-Acetylpenicillamine	S-Nitroso-N-Acetylpenicillamine results in decreased secretion of EDN1 protein	10993771
D012964	Sodium	cariporide inhibits the reaction [EDN1 protein results in increased uptake of Sodium]	15681704
D012964	Sodium	EDN1 protein results in increased uptake of Sodium	15681704
D012964	Sodium	EDN1 protein affects the export of Sodium	16340664
D012964	Sodium	EDN1 protein affects the susceptibility to Sodium	16340664
C017947	sodium arsenite	RELA protein affects the reaction [sodium arsenite results in increased expression of EDN1 mRNA]	28470405
C017947	sodium arsenite	sodium arsenite inhibits the reaction [EDN1 protein results in increased expression of EDNRB]	28470405
C017947	sodium arsenite	sodium arsenite inhibits the reaction [EDN1 protein results in increased expression of MITF]	28470405
C017947	sodium arsenite	sodium arsenite results in increased expression of EDN1 mRNA	28470405
C017947	sodium arsenite	sodium arsenite results in increased expression of EDN1 protein	28470405
D012965	Sodium Chloride	[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA	18823320
D012965	Sodium Chloride	[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of EDN1	22431579
D017673	Sodium Chloride, Dietary	[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in increased expression of EDN1 protein	7721389
D017673	Sodium Chloride, Dietary	Mibefradil inhibits the reaction [[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA]	8934362
D017673	Sodium Chloride, Dietary	[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA	8934362
D017673	Sodium Chloride, Dietary	[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 protein	1860718
D053260	Soot	Soot results in increased expression of EDN1 mRNA	31022427
D053260	Soot	Soot affects the expression of EDN1 mRNA	26551751
C517409	stattic	stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]	30670587
C517409	stattic	stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]	30670587
C517409	stattic	stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]	30670587
C517409	stattic	stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein]	30670587
D019311	Staurosporine	Staurosporine results in decreased activity of EDN1 protein	15464066
C031183	stearic acid	stearic acid results in increased expression of EDN1 mRNA	16895544
C031183	stearic acid	stearic acid results in increased expression of EDN1 protein	16895544
D013311	Streptozocin	diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]	20691780
D013311	Streptozocin	Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]	20691780
D013311	Streptozocin	Bezafibrate inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]	12967931
D013311	Streptozocin	Streptozocin results in increased expression of EDN1 mRNA	12458661; 12967931;
D013311	Streptozocin	benazepril inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]	15015294
D013311	Streptozocin	Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]	15015294
D013311	Streptozocin	Streptozocin results in increased expression of EDN1 mRNA	15015294
D013392	Sucralfate	Sucralfate inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]	10423059
D013458	Sulfur Dioxide	Sulfur Dioxide results in increased expression of EDN1 mRNA	20083630
D013458	Sulfur Dioxide	Sulfur Dioxide results in increased expression of EDN1 protein	20083630
D000077210	Sunitinib	Sunitinib results in decreased expression of EDN1 mRNA	31533062
D013481	Superoxides	EDN1 protein results in increased abundance of Superoxides	23940720
D013481	Superoxides	NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	23940720
D013481	Superoxides	EDN1 protein results in increased abundance of Superoxides	11509453
D013481	Superoxides	PD 156707 inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	11509453
D013481	Superoxides	Catechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	20977430
D013481	Superoxides	[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides	20977430
D013481	Superoxides	EDN1 protein results in increased abundance of Superoxides	20977430
D013481	Superoxides	NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]	20977430
D013481	Superoxides	Polyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]	20977430
D013481	Superoxides	acetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	12600921
D013481	Superoxides	[Atrasentan binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	12600921
D013481	Superoxides	diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	12600921
D013481	Superoxides	EDN1 protein results in increased abundance of Superoxides	12600921; 15302986;
D013481	Superoxides	Hydralazine inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	15302986
D013481	Superoxides	olmesartan inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	15302986
D016559	Tacrolimus	Tacrolimus results in increased expression of EDN1 mRNA	9517403; 9931093;
D016559	Tacrolimus	Tacrolimus results in increased expression of EDN1 protein	9931093
C061133	tamibarotene	tamibarotene results in increased expression of EDN1 mRNA	15498508
D013629	Tamoxifen	Estradiol promotes the reaction [[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA]	19943105
D013629	Tamoxifen	[Fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDN1 mRNA	19943105
D013629	Tamoxifen	Tamoxifen results in increased expression of EDN1 mRNA	19943105
D013629	Tamoxifen	[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA	19943105
D013629	Tamoxifen	Tamoxifen affects the expression of EDN1 mRNA	17555576
C021751	tanshinone	tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]	28985491
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of EDN1 protein	15556138
C424912	TBC 3214	TBC 3214 results in decreased expression of EDN1 mRNA	15580650
C424912	TBC 3214	TBC 3214 results in decreased expression of EDN1 protein	15580650
D000077333	Telmisartan	Telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein]	20888384
C001803	tempol	tempol inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]	17391658
C001803	tempol	tempol results in decreased expression of EDN1 mRNA	28039404
C001803	tempol	tempol results in decreased expression of EDN1 protein	28039404
D000068698	Tenofovir	coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]	23640862
D000068698	Tenofovir	Tenofovir results in increased secretion of EDN1 protein	23640862
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of EDN1 mRNA	23410634
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of EDN1 mRNA	12414654
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of EDN1 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of EDN1 mRNA	21592394
D013739	Testosterone	Testosterone affects the expression of EDN1 mRNA	12122504; 14616470;
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of EDN1 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of EDN1 mRNA	16714409
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of EDN1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EDN1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of EDN1 mRNA	17942748; 19933214;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of EDN1 mRNA	16120747; 17975115; 31270306;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of EDN1 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of EDN1 mRNA	21724226
D013755	Tetradecanoylphorbol Acetate	Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein]	17105827
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein	17105827
D013806	Theophylline	Theophylline inhibits the reaction [CSF2 protein results in increased expression of EDN1 mRNA]	10374451
D013853	Thioacetamide	Thioacetamide results in increased expression of EDN1 mRNA	23411599
D017392	Thiobarbituric Acid Reactive Substances	EDN1 protein results in increased abundance of Thiobarbituric Acid Reactive Substances	15302986
D017392	Thiobarbituric Acid Reactive Substances	Hydralazine inhibits the reaction [EDN1 protein results in increased abundance of Thiobarbituric Acid Reactive Substances]	15302986
D017392	Thiobarbituric Acid Reactive Substances	olmesartan inhibits the reaction [EDN1 protein results in increased abundance of Thiobarbituric Acid Reactive Substances]	15302986
D013928	Thromboxane A2	EDN1 protein results in increased secretion of Thromboxane A2	12056553
D013929	Thromboxane B2	EDN1 results in increased secretion of Thromboxane B2	7507780
D013936	Thymidine	EDN1 protein results in increased uptake of Thymidine	10100047
C016151	tinuvin	tinuvin analog results in decreased expression of EDN1 mRNA	30315675
D000069447	Tiotropium Bromide	Tiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]	22796455
C009495	titanium dioxide	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of EDN1 mRNA	29950665
C009495	titanium dioxide	titanium dioxide results in increased expression of EDN1 mRNA	23409001; 23557971;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of EDN1 mRNA	29501877
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of EDN1 mRNA	27404394; 27865774;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of EDN1	19637760
C483909	torcetrapib	torcetrapib affects the expression of and affects the activity of EDN1 protein	21920972
D014212	Tretinoin	Tretinoin results in increased expression of EDN1 mRNA	18230668
D014212	Tretinoin	[Tretinoin co-treated with Ascorbic Acid] results in increased expression of EDN1 mRNA	16443354
D014212	Tretinoin	Tretinoin results in increased expression of EDN1 mRNA	15498508
D014212	Tretinoin	Tretinoin results in decreased expression of EDN1 protein	17551590
D014212	Tretinoin	Tretinoin results in decreased expression of EDN1 protein	16619265
C032910	triadimefon	triadimefon results in decreased expression of EDN1 mRNA	26705709
C011559	tributyltin	tributyltin results in decreased expression of EDN1 mRNA	29505797
C011559	tributyltin	tributyltin results in increased expression of EDN1 mRNA	31129395
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]	27297870; 29165873;
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]	29165873
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]	27297870
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of EDN1 mRNA	24935251
C012589	trichostatin A	trichostatin A results in increased expression of EDN1 mRNA	24935251; 26272509; 26705709;
D014260	Triclosan	Triclosan results in decreased expression of EDN1 mRNA	30510588
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EDN1 mRNA	26743178
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EDN1 mRNA	26179874
D000077288	Troglitazone	Troglitazone inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]	17666345
D000077288	Troglitazone	Troglitazone inhibits the reaction [INS results in increased secretion of EDN1 protein]	9920814
D000077288	Troglitazone	Troglitazone results in decreased expression of EDN1 mRNA	9920814
D000077288	Troglitazone	Troglitazone results in decreased secretion of EDN1 protein	9920814
C113580	U 0126	U 0126 inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	24376792
C113580	U 0126	U 0126 inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]	12411397
C113580	U 0126	U 0126 inhibits the reaction [EDN1 protein results in increased expression of HOMER1 mRNA alternative form]	16786172
C113580	U 0126	U 0126 inhibits the reaction [EDN1 protein results in increased expression of JUN mRNA]	12169099
C113580	U 0126	U 0126 inhibits the reaction [EDN1 protein results in increased phosphorylation of CREB1 protein]	14741741
C113580	U 0126	U 0126 inhibits the reaction [EDN1 protein results in increased phosphorylation of EIF4EBP1 protein]	12411397
C113580	U 0126	U 0126 inhibits the reaction [EDN1 protein results in increased phosphorylation of GSK3A protein]	17993264
C113580	U 0126	U 0126 inhibits the reaction [EDN1 protein results in increased phosphorylation of GSK3B protein]	17993264
D014520	Urethane	Urethane results in decreased expression of EDN1 mRNA	28818685
D014527	Uric Acid	Resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 mRNA]	25493383
D014527	Uric Acid	Resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 protein]	25493383
D014527	Uric Acid	Uric Acid results in increased expression of EDN1 mRNA	25493383
D014527	Uric Acid	Uric Acid results in increased expression of EDN1 protein	25493383
C027278	urovision	urovision results in increased expression of EDN1 protein	9413771
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of EDN1 mRNA	15556138
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of EDN1 protein	15556138
C005466	ursolic acid	ursolic acid inhibits the reaction [Choline results in increased expression of EDN1 protein]	27567547
D014635	Valproic Acid	Valproic Acid affects the expression of EDN1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of EDN1 mRNA	23179753; 24383497; 24935251; 26705709; 28001369;
D014635	Valproic Acid	Valproic Acid affects the expression of EDN1 mRNA	17292431
D000068756	Valsartan	[Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein	11136700
D014638	Vanadates	Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]]	29165873
D014638	Vanadates	Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]]	29165873
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of EDN1 mRNA	16330358
D001335	Vehicle Emissions	[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of EDN1 mRNA	19150882
D001335	Vehicle Emissions	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of EDN1 mRNA]	19150882
D001335	Vehicle Emissions	[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in increased expression of EDN1 mRNA	19891982
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of EDN1 mRNA	21920430
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of EDN1 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of EDN1 mRNA	17065432; 20197249;
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of EDN1 mRNA	20980218; 23897985;
D001335	Vehicle Emissions	Vehicle Emissions results in increased metabolism of EDN1 protein	23897985
D001335	Vehicle Emissions	Vehicle Emissions results in increased susceptibility to EDN1 protein	19535675
D014700	Verapamil	Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]	28942281
D014700	Verapamil	Verapamil inhibits the reaction [EDN1 protein results in increased expression of NPPB protein]	28942281
C025643	vinclozolin	vinclozolin results in increased methylation of EDN1 promoter	22570695
D024483	Vitamin K 3	Vitamin K 3 affects the expression of EDN1 mRNA	20044591; 23410634;
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of EDN1 mRNA	12414654
D014867	Water	EDN1 protein affects the export of Water	16340664
D000077191	Wortmannin	Wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]	12839867
C108830	Y 27632	Y 27632 results in decreased activity of EDN1 protein	15939040
C108830	Y 27632	Y 27632 results in decreased activity of EDN1 protein	12605241
C108830	Y 27632	Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]	11739382
C062735	zafirlukast	zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 mRNA]	11372388
C062735	zafirlukast	zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 protein]	11372388
C062735	zafirlukast	zafirlukast results in decreased expression of EDN1 protein	12781059
C415840	ZD 2574	ZD 2574 results in increased expression of EDN1 protein	11046091
C511404	ZD4054	Estradiol promotes the reaction [[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA]	19943105
C511404	ZD4054	[Fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDN1 mRNA	19943105
C511404	ZD4054	[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA	19943105
C511404	ZD4054	ZD4054 results in decreased expression of EDN1 mRNA	19943105
D015029	Zeranol	Zeranol inhibits the reaction [Homocysteine affects the expression of EDN1 protein]	16757814
D015215	Zidovudine	coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein]	23640862
D015215	Zidovudine	Zidovudine results in increased secretion of EDN1 protein	23640862
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of EDN1 mRNA	18593933
D000077211	Zoledronic Acid	Zoledronic Acid results in increased expression of EDN1 mRNA	24714768

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0165	Cleavage on pair of basic residues
KW-0903	Direct protein sequencing
KW-0225	Disease mutation
KW-1015	Disulfide bond
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal
KW-0838	Vasoactive
KW-0839	Vasoconstrictor

Interpro

InterPro ID	InterPro Term
IPR020475	Endothelin
IPR019764	Endothelin_toxin_CS
IPR001928	Endothln-like_toxin

PROSITE

PROSITE ID	PROSITE Term
PS00270	ENDOTHELIN

Pfam

Pfam ID	Pfam Term
PF00322	Endothelin

Gene: EDN1

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction