CleftGeneDB-Search

Gene: KRT18

Basic information

Tag	Content
Uniprot ID	P05783; Q53G38; Q5U0N8; Q9BW26;
Entrez ID	3875
Genbank protein ID	AAH04253.1; AAX07828.1; CAA31377.1; AAH72017.1; CAA31369.1; CAA31375.1; AAH08636.1; AAH20982.1; AAH00698.1; AAH00180.1; AAV38219.1; AAA59461.1; BAD96813.1;
Genbank nucleotide ID	NM_000224.2; NM_199187.1;
Ensembl protein ID	ENSP00000373487; ENSP00000373489;
Ensembl nucleotide ID	ENSG00000111057
Gene name	Keratin, type I cytoskeletal 18
Gene symbol	KRT18
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Manually collected
Reference	28232668
Functional description	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Sequence	MSFTTRSTFS TNYRSLGSVQ APSYGARPVS SAASVYAGAG GSGSRISVSR STSFRGGMGS 60 GGLATGIAGG LAGMGGIQNE KETMQSLNDR LASYLDRVRS LETENRRLES KIREHLEKKG 120 PQVRDWSHYF KIIEDLRAQI FANTVDNARI VLQIDNARLA ADDFRVKYET ELAMRQSVEN 180 DIHGLRKVID DTNITRLQLE TEIEALKEEL LFMKKNHEEE VKGLQAQIAS SGLTVEVDAP 240 KSQDLAKIMA DIRAQYDELA RKNREELDKY WSQQIEESTT VVTTQSAEVG AAETTLTELR 300 RTVQSLEIDL DSMRNLKASL ENSLREVEAR YALQMEQLNG ILLHLESELA QTRAEGQRQA 360 QEYEALLNIK VKLEAEIATY RRLLEDGEDF NLGDALDSSN SMQTIQKTTT RRIVDGKVVS 420 ETNDTKVLRH

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Species	Evidence	Details
1:1 ortholog	KRT18	506480	F6S1Q0	Bos taurus	Prediction	More>>
1:1 ortholog	KRT18	3875	P05783	Homo sapiens	Publication	More>>
1:1 ortholog	Krt18	16668	P05784	Mus musculus	Prediction	More>>
1:1 ortholog	KRT18	451923	H2Q609	Pan troglodytes	Prediction	More>>
1:1 ortholog			A0A4X1WBK2	Sus scrofa	Prediction	More>>
1:1 ortholog	Krt18	294853	Q5BJY9	Rattus norvegicus	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
KRT18	rs3741442A>G	GWAS	28232668

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs369198778	p.Ser2Thr	missense variant	-	NC_000012.12:g.52949178G>C	ESP,ExAC,TOPMed,gnomAD
rs756991398	p.Phe3Cys	missense variant	-	NC_000012.12:g.52949181T>G	ExAC,gnomAD
rs76301931	p.Thr4Ile	missense variant	-	NC_000012.12:g.52949184C>T	ExAC,TOPMed,gnomAD
rs76301931	p.Thr4Ser	missense variant	-	NC_000012.12:g.52949184C>G	ExAC,TOPMed,gnomAD
rs1241148678	p.Thr4Ala	missense variant	-	NC_000012.12:g.52949183A>G	gnomAD
rs1270182586	p.Arg6Cys	missense variant	-	NC_000012.12:g.52949189C>T	TOPMed,gnomAD
rs775547844	p.Ser7Tyr	missense variant	-	NC_000012.12:g.52949193C>A	ExAC,gnomAD
rs945689746	p.Phe9Cys	missense variant	-	NC_000012.12:g.52949199T>G	TOPMed,gnomAD
rs1381635123	p.Thr11Ile	missense variant	-	NC_000012.12:g.52949205C>T	gnomAD
rs748718547	p.Thr11Ala	missense variant	-	NC_000012.12:g.52949204A>G	ExAC,gnomAD
rs1166470792	p.Tyr13Cys	missense variant	-	NC_000012.12:g.52949211A>G	TOPMed
rs766809169	p.Arg14Trp	missense variant	-	NC_000012.12:g.52949213C>T	ExAC,gnomAD
rs777157164	p.Arg14Gln	missense variant	-	NC_000012.12:g.52949214G>A	ExAC,TOPMed,gnomAD
rs1447813465	p.Ser15Phe	missense variant	-	NC_000012.12:g.52949217C>T	gnomAD
rs753311520	p.Ser15Pro	missense variant	-	NC_000012.12:g.52949216T>C	ExAC,gnomAD
rs79476176	p.Gly17Val	missense variant	-	NC_000012.12:g.52949223G>T	ExAC,TOPMed,gnomAD
rs79476176	p.Gly17Asp	missense variant	-	NC_000012.12:g.52949223G>A	ExAC,TOPMed,gnomAD
rs1239570081	p.Gly17Arg	missense variant	-	NC_000012.12:g.52949222G>C	gnomAD
rs147350452	p.Ser18Tyr	missense variant	-	NC_000012.12:g.52949226C>A	ESP,ExAC,TOPMed,gnomAD
rs1479948631	p.Ser18Thr	missense variant	-	NC_000012.12:g.52949225T>A	TOPMed
rs147350452	p.Ser18Cys	missense variant	-	NC_000012.12:g.52949226C>G	ESP,ExAC,TOPMed,gnomAD
rs1307456366	p.Tyr24Cys	missense variant	-	NC_000012.12:g.52949244A>G	TOPMed
rs1239572921	p.Tyr24Ter	stop gained	-	NC_000012.12:g.52949245C>G	gnomAD
rs750200705	p.Gly25Cys	missense variant	-	NC_000012.12:g.52949246G>T	ExAC,TOPMed,gnomAD
rs750200705	p.Gly25Arg	missense variant	-	NC_000012.12:g.52949246G>C	ExAC,TOPMed,gnomAD
rs750200705	p.Gly25Ser	missense variant	-	NC_000012.12:g.52949246G>A	ExAC,TOPMed,gnomAD
rs78514003	p.Ala26Thr	missense variant	-	NC_000012.12:g.52949249G>A	TOPMed,gnomAD
rs1368538220	p.Arg27Pro	missense variant	-	NC_000012.12:g.52949253G>C	gnomAD
rs77825282	p.Arg27Trp	missense variant	-	NC_000012.12:g.52949252C>T	TOPMed,gnomAD
rs74379840	p.Pro28Arg	missense variant	-	NC_000012.12:g.52949256C>G	ExAC,TOPMed,gnomAD
COSM3871921	p.Pro28Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52949256C>T	NCI-TCGA Cosmic
rs74379840	p.Pro28Gln	missense variant	-	NC_000012.12:g.52949256C>A	ExAC,TOPMed,gnomAD
rs1465913307	p.Val29Ile	missense variant	-	NC_000012.12:g.52949258G>A	gnomAD
rs1398440164	p.Ser31Cys	missense variant	-	NC_000012.12:g.52949264A>T	TOPMed,gnomAD
rs374064321	p.Ser31Ile	missense variant	-	NC_000012.12:g.52949265G>T	ESP,ExAC,TOPMed,gnomAD
rs74953757	p.Ala32Ser	missense variant	-	NC_000012.12:g.52949267G>T	TOPMed,gnomAD
rs1297779360	p.Ala32Val	missense variant	-	NC_000012.12:g.52949268C>T	TOPMed,gnomAD
rs78343594	p.Ser34Arg	missense variant	-	NC_000012.12:g.52949275C>A	ESP,ExAC,TOPMed,gnomAD
rs1427838806	p.Ser34Thr	missense variant	-	NC_000012.12:g.52949274G>C	TOPMed
rs1243265591	p.Val35Ile	missense variant	-	NC_000012.12:g.52949276G>A	gnomAD
rs1227971336	p.Tyr36His	missense variant	-	NC_000012.12:g.52949279T>C	gnomAD
rs891346528	p.Tyr36Ser	missense variant	-	NC_000012.12:g.52949280A>C	TOPMed,gnomAD
rs1281260117	p.Ala37Thr	missense variant	-	NC_000012.12:g.52949282G>A	gnomAD
rs1319072747	p.Ala37Gly	missense variant	-	NC_000012.12:g.52949283C>G	gnomAD
rs77999286	p.Gly38Cys	missense variant	-	NC_000012.12:g.52949285G>T	TOPMed,gnomAD
rs77999286	p.Gly38Ser	missense variant	-	NC_000012.12:g.52949285G>A	TOPMed,gnomAD
rs1486318507	p.Gly38Asp	missense variant	-	NC_000012.12:g.52949286G>A	TOPMed
rs771828609	p.Ala39Val	missense variant	-	NC_000012.12:g.52949289C>T	ExAC,gnomAD
rs773038025	p.Gly40Arg	missense variant	-	NC_000012.12:g.52949291G>A	ExAC,gnomAD
rs759814479	p.Gly41Ser	missense variant	-	NC_000012.12:g.52949294G>A	ExAC,TOPMed,gnomAD
rs1256261258	p.Gly41Ala	missense variant	-	NC_000012.12:g.52949295G>C	gnomAD
NCI-TCGA novel	p.Gly41Asp	missense variant	-	NC_000012.12:g.52949295G>A	NCI-TCGA
rs770250195	p.Ser42Pro	missense variant	-	NC_000012.12:g.52949297T>C	ExAC,gnomAD
rs75441140	p.Gly43Ser	missense variant	-	NC_000012.12:g.52949300G>A	ExAC,TOPMed,gnomAD
rs75441140	p.Gly43Arg	missense variant	-	NC_000012.12:g.52949300G>C	ExAC,TOPMed,gnomAD
rs1263244013	p.Gly43Asp	missense variant	-	NC_000012.12:g.52949301G>A	gnomAD
rs75441140	p.Gly43Cys	missense variant	-	NC_000012.12:g.52949300G>T	ExAC,TOPMed,gnomAD
rs763522746	p.Ser44Ala	missense variant	-	NC_000012.12:g.52949303T>G	ExAC,gnomAD
rs1447084165	p.Ser44Cys	missense variant	-	NC_000012.12:g.52949304C>G	gnomAD
RCV000049578	p.Arg45Pro	missense variant	Hepatitis c virus, susceptibility to	NC_000012.12:g.52949307G>C	ClinVar
rs1478096062	p.Arg45Trp	missense variant	-	NC_000012.12:g.52949306C>T	TOPMed,gnomAD
rs200221269	p.Arg45Pro	missense variant	-	NC_000012.12:g.52949307G>C	ExAC,TOPMed,gnomAD
rs760412718	p.Ile46Phe	missense variant	-	NC_000012.12:g.52949309A>T	ExAC,gnomAD
rs760412718	p.Ile46Leu	missense variant	-	NC_000012.12:g.52949309A>C	ExAC,gnomAD
rs1452035555	p.Ser47Phe	missense variant	-	NC_000012.12:g.52949313C>T	TOPMed
rs761933454	p.Val48Ala	missense variant	-	NC_000012.12:g.52949316T>C	ExAC,gnomAD
rs1359140246	p.Val48Leu	missense variant	-	NC_000012.12:g.52949315G>C	TOPMed,gnomAD
rs1359140246	p.Val48Met	missense variant	-	NC_000012.12:g.52949315G>A	TOPMed,gnomAD
rs78479490	p.Arg50Cys	missense variant	-	NC_000012.12:g.52949321C>T	TOPMed,gnomAD
rs11551633	p.Arg50Leu	missense variant	-	NC_000012.12:g.52949322G>T	ExAC,gnomAD
rs1394324153	p.Ser51Phe	missense variant	-	NC_000012.12:g.52949325C>T	gnomAD
rs1333552689	p.Thr52Ile	missense variant	-	NC_000012.12:g.52949328C>T	gnomAD
rs1341730231	p.Ser53Gly	missense variant	-	NC_000012.12:g.52949330A>G	gnomAD
rs750714548	p.Phe54Leu	missense variant	-	NC_000012.12:g.52949333T>C	ExAC
rs1429253751	p.Phe54Ser	missense variant	-	NC_000012.12:g.52949334T>C	TOPMed
rs1429253751	p.Phe54Cys	missense variant	-	NC_000012.12:g.52949334T>G	TOPMed
rs78718957	p.Arg55Trp	missense variant	-	NC_000012.12:g.52949336A>T	TOPMed,gnomAD
rs755849994	p.Arg55Thr	missense variant	-	NC_000012.12:g.52949337G>C	ExAC
rs76183244	p.Gly56Asp	missense variant	-	NC_000012.12:g.52949340G>A	ExAC,TOPMed,gnomAD
rs753674663	p.Gly57Cys	missense variant	-	NC_000012.12:g.52949342G>T	ExAC,gnomAD
rs1317616802	p.Gly59Arg	missense variant	-	NC_000012.12:g.52949348G>A	TOPMed,gnomAD
rs1317616802	p.Gly59Trp	missense variant	-	NC_000012.12:g.52949348G>T	TOPMed,gnomAD
rs1226267547	p.Gly59Glu	missense variant	-	NC_000012.12:g.52949349G>A	gnomAD
rs1226267547	p.Gly59Val	missense variant	-	NC_000012.12:g.52949349G>T	gnomAD
NCI-TCGA novel	p.Ser60Tyr	missense variant	-	NC_000012.12:g.52949352C>A	NCI-TCGA
rs779038487	p.Gly61Trp	missense variant	-	NC_000012.12:g.52949354G>T	ExAC,TOPMed,gnomAD
COSM1362617	p.Gly61Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52949354G>A	NCI-TCGA Cosmic
rs779038487	p.Gly61Arg	missense variant	-	NC_000012.12:g.52949354G>C	ExAC,TOPMed,gnomAD
rs747629868	p.Gly62Ser	missense variant	-	NC_000012.12:g.52949357G>A	ExAC,gnomAD
rs1216443356	p.Ala64Gly	missense variant	-	NC_000012.12:g.52949364C>G	TOPMed,gnomAD
rs1463167645	p.Thr65Ile	missense variant	-	NC_000012.12:g.52949367C>T	gnomAD
rs777553435	p.Gly66Arg	missense variant	-	NC_000012.12:g.52949369G>C	ExAC,TOPMed,gnomAD
rs77364359	p.Ile67Met	missense variant	-	NC_000012.12:g.52949374A>G	TOPMed,gnomAD
rs1260779156	p.Ala68Thr	missense variant	-	NC_000012.12:g.52949375G>A	TOPMed,gnomAD
rs1260779156	p.Ala68Ser	missense variant	-	NC_000012.12:g.52949375G>T	TOPMed,gnomAD
rs11551624	p.Gly69Arg	missense variant	-	NC_000012.12:g.52949378G>A	gnomAD
rs11551624	p.Gly69Trp	missense variant	-	NC_000012.12:g.52949378G>T	gnomAD
rs532875586	p.Gly69Ala	missense variant	-	NC_000012.12:g.52949379G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs1172136071	p.Gly70Asp	missense variant	-	NC_000012.12:g.52949382G>A	gnomAD
rs1424932919	p.Ala72Ser	missense variant	-	NC_000012.12:g.52949387G>T	gnomAD
rs1402412772	p.Gly73Arg	missense variant	-	NC_000012.12:g.52949390G>A	gnomAD
rs1462527970	p.Met74Thr	missense variant	-	NC_000012.12:g.52949394T>C	TOPMed
COSM1299561	p.Met74Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52949393A>T	NCI-TCGA Cosmic
rs1420009357	p.Gly75Arg	missense variant	-	NC_000012.12:g.52949396G>C	gnomAD
COSM4042952	p.Gly75Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52949396G>A	NCI-TCGA Cosmic
rs1372602238	p.Gly76Arg	missense variant	-	NC_000012.12:g.52949399G>C	TOPMed
rs1340333805	p.Ile77Thr	missense variant	-	NC_000012.12:g.52949403T>C	gnomAD
rs1161922697	p.Asn79Asp	missense variant	-	NC_000012.12:g.52949408A>G	gnomAD
rs199572098	p.Glu80Lys	missense variant	-	NC_000012.12:g.52949411G>A	TOPMed,gnomAD
rs774882680	p.Glu82Lys	missense variant	-	NC_000012.12:g.52949417G>A	ExAC,gnomAD
rs79346135	p.Met84Ile	missense variant	-	NC_000012.12:g.52949425G>A	TOPMed,gnomAD
rs1188380011	p.Ser86Thr	missense variant	-	NC_000012.12:g.52949430G>C	TOPMed
COSM431366	p.Asp89Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52949438G>A	NCI-TCGA Cosmic
rs1397020078	p.Arg90Cys	missense variant	-	NC_000012.12:g.52949441C>T	TOPMed,gnomAD
rs1434610693	p.Ala92Pro	missense variant	-	NC_000012.12:g.52949447G>C	TOPMed,gnomAD
rs551257529	p.Ser93Pro	missense variant	-	NC_000012.12:g.52949450T>C	1000Genomes
rs1191605617	p.Asp96Asn	missense variant	-	NC_000012.12:g.52949459G>A	gnomAD
rs760985349	p.Arg99Ser	missense variant	-	NC_000012.12:g.52949470G>T	ExAC,TOPMed,gnomAD
rs796361379	p.Ser100Arg	missense variant	-	NC_000012.12:g.52949473C>G	TOPMed,gnomAD
rs144926827	p.Glu102Val	missense variant	-	NC_000012.12:g.52949478A>T	ESP,ExAC,TOPMed,gnomAD
rs1273250739	p.Thr103Asn	missense variant	-	NC_000012.12:g.52949481C>A	TOPMed,gnomAD
rs1273250739	p.Thr103Ser	missense variant	-	NC_000012.12:g.52949481C>G	TOPMed,gnomAD
rs61136606	p.Thr103Ala	missense variant	-	NC_000012.12:g.52949480A>G	ExAC,gnomAD
rs61136606	p.Thr103Ala	missense variant	Cirrhosis (CIRRH)	NC_000012.12:g.52949480A>G	UniProt,dbSNP
VAR_023054	p.Thr103Ala	missense variant	Cirrhosis (CIRRH)	NC_000012.12:g.52949480A>G	UniProt
RCV000056434	p.Thr103Ala	missense variant	-	NC_000012.12:g.52949480A>G	ClinVar
rs1218968384	p.Glu104Gly	missense variant	-	NC_000012.12:g.52949484A>G	gnomAD
rs1164534748	p.Glu104Asp	missense variant	-	NC_000012.12:g.52949485G>C	TOPMed
rs1418823110	p.Glu104Ter	stop gained	-	NC_000012.12:g.52949483G>T	TOPMed
rs11551638	p.Arg106Trp	missense variant	-	NC_000012.12:g.52949489C>T	TOPMed,gnomAD
rs765260052	p.Arg106Leu	missense variant	-	NC_000012.12:g.52949490G>T	ExAC,gnomAD
rs752738391	p.Ser110Thr	missense variant	-	NC_000012.12:g.52949502G>C	ExAC,gnomAD
rs1360506073	p.Ser110Gly	missense variant	-	NC_000012.12:g.52949501A>G	gnomAD
rs777429135	p.Arg113Trp	missense variant	-	NC_000012.12:g.52949510C>T	ExAC
rs1481173368	p.His115Leu	missense variant	-	NC_000012.12:g.52949517A>T	gnomAD
rs1241736628	p.Glu117Lys	missense variant	-	NC_000012.12:g.52949522G>A	gnomAD
rs749637522	p.Lys118Asn	missense variant	-	NC_000012.12:g.52949527G>C	ExAC,TOPMed,gnomAD
rs147945345	p.Lys119Arg	missense variant	-	NC_000012.12:g.52949529A>G	ESP,ExAC,TOPMed,gnomAD
rs1222130911	p.Lys119Asn	missense variant	-	NC_000012.12:g.52949530G>C	gnomAD
NCI-TCGA novel	p.Gly120Glu	missense variant	-	NC_000012.12:g.52949532G>A	NCI-TCGA
rs796088051	p.Pro121Ser	missense variant	-	NC_000012.12:g.52949534C>T	TOPMed,gnomAD
rs1420153393	p.Gln122Pro	missense variant	-	NC_000012.12:g.52949538A>C	TOPMed,gnomAD
rs748671089	p.Val123Ala	missense variant	-	NC_000012.12:g.52949541T>C	ExAC,TOPMed,gnomAD
rs748671089	p.Val123Asp	missense variant	-	NC_000012.12:g.52949541T>A	ExAC,TOPMed,gnomAD
rs772097116	p.Asp125His	missense variant	-	NC_000012.12:g.52949546G>C	ExAC,TOPMed,gnomAD
rs140324943	p.Trp126Cys	missense variant	-	NC_000012.12:g.52949551G>T	1000Genomes,ExAC,gnomAD
rs1213337755	p.Trp126Arg	missense variant	-	NC_000012.12:g.52949549T>A	gnomAD
rs57758506	p.His128Leu	missense variant	-	NC_000012.12:g.52949556A>T	ESP,ExAC,TOPMed,gnomAD
rs57758506	p.His128Leu	missense variant	Cirrhosis (CIRRH)	NC_000012.12:g.52949556A>T	UniProt,dbSNP
VAR_003852	p.His128Leu	missense variant	Cirrhosis (CIRRH)	NC_000012.12:g.52949556A>T	UniProt
RCV000015687	p.His128Leu	missense variant	Cirrhosis, noncryptogenic, susceptibility to	NC_000012.12:g.52949556A>T	ClinVar
rs1442739455	p.Ile132Thr	missense variant	-	NC_000012.12:g.52949568T>C	TOPMed,gnomAD
rs1348614728	p.Ile133Met	missense variant	-	NC_000012.12:g.52949572C>G	TOPMed,gnomAD
rs1227737710	p.Glu134Gln	missense variant	-	NC_000012.12:g.52949573G>C	TOPMed,gnomAD
rs759391099	p.Arg137Trp	missense variant	-	NC_000012.12:g.52949582A>T	ExAC,gnomAD
rs766333046	p.Ala138Thr	missense variant	-	NC_000012.12:g.52949585G>A	ExAC,gnomAD
rs955495297	p.Gln139Arg	missense variant	-	NC_000012.12:g.52949589A>G	TOPMed,gnomAD
rs1451370716	p.Ile140Val	missense variant	-	NC_000012.12:g.52950328A>G	gnomAD
rs745911935	p.Phe141Leu	missense variant	-	NC_000012.12:g.52950333C>A	ExAC,TOPMed,gnomAD
rs770066827	p.Ala142Thr	missense variant	-	NC_000012.12:g.52950334G>A	ExAC,TOPMed,gnomAD
rs768434116	p.Asp146Val	missense variant	-	NC_000012.12:g.52950347A>T	ExAC,TOPMed,gnomAD
rs749538159	p.Asp146His	missense variant	-	NC_000012.12:g.52950346G>C	ExAC,TOPMed,gnomAD
rs768434116	p.Asp146Gly	missense variant	-	NC_000012.12:g.52950347A>G	ExAC,TOPMed,gnomAD
rs749538159	p.Asp146Asn	missense variant	-	NC_000012.12:g.52950346G>A	ExAC,TOPMed,gnomAD
rs1342840924	p.Asn147Thr	missense variant	-	NC_000012.12:g.52950350A>C	gnomAD
rs200694483	p.Arg149His	missense variant	-	NC_000012.12:g.52950356G>A	ExAC,TOPMed,gnomAD
rs1293064587	p.Arg149Cys	missense variant	-	NC_000012.12:g.52950355C>T	gnomAD
rs200694483	p.Arg149Leu	missense variant	-	NC_000012.12:g.52950356G>T	ExAC,TOPMed,gnomAD
rs771870687	p.Ile150Met	missense variant	-	NC_000012.12:g.52950360C>G	ExAC
rs59979366	p.Ile150Val	missense variant	-	NC_000012.12:g.52950358A>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000056437	p.Ile150Val	missense variant	-	NC_000012.12:g.52950358A>G	ClinVar
rs1252659630	p.Val151Ile	missense variant	-	NC_000012.12:g.52950361G>A	gnomAD
rs1194791264	p.Ile154Thr	missense variant	-	NC_000012.12:g.52950371T>C	TOPMed,gnomAD
rs1253749291	p.Asp155Glu	missense variant	-	NC_000012.12:g.52950375C>A	TOPMed
rs760161076	p.Asn156Ser	missense variant	-	NC_000012.12:g.52950377A>G	ExAC,gnomAD
rs776198491	p.Ala157Thr	missense variant	-	NC_000012.12:g.52950379G>A	ExAC,gnomAD
rs553275094	p.Arg158Gly	missense variant	-	NC_000012.12:g.52950382C>G	ExAC,gnomAD
rs369948432	p.Arg158His	missense variant	-	NC_000012.12:g.52950383G>A	ESP,ExAC,TOPMed,gnomAD
rs553275094	p.Arg158Cys	missense variant	-	NC_000012.12:g.52950382C>T	ExAC,gnomAD
rs1277229176	p.Leu159Ile	missense variant	-	NC_000012.12:g.52950385C>A	TOPMed
rs11551626	p.Ala161Thr	missense variant	-	NC_000012.12:g.52950391G>A	gnomAD
rs11551626	p.Ala161Ser	missense variant	-	NC_000012.12:g.52950391G>T	gnomAD
rs898492782	p.Arg165Thr	missense variant	-	NC_000012.12:g.52950404G>C	TOPMed,gnomAD
NCI-TCGA novel	p.Lys167Glu	missense variant	-	NC_000012.12:g.52950409A>G	NCI-TCGA
rs1372689032	p.Tyr168Cys	missense variant	-	NC_000012.12:g.52950752A>G	gnomAD
rs777576325	p.Ala173Gly	missense variant	-	NC_000012.12:g.52950767C>G	ExAC,TOPMed,gnomAD
rs758121818	p.Ala173Pro	missense variant	-	NC_000012.12:g.52950766G>C	ExAC,gnomAD
rs746898922	p.Arg175Cys	missense variant	-	NC_000012.12:g.52950772C>T	ExAC,gnomAD
rs1217770008	p.Arg175Leu	missense variant	-	NC_000012.12:g.52950773G>T	TOPMed,gnomAD
rs1217770008	p.Arg175His	missense variant	-	NC_000012.12:g.52950773G>A	TOPMed,gnomAD
rs781231306	p.Gln176Arg	missense variant	-	NC_000012.12:g.52950776A>G	ExAC,gnomAD
rs1217896141	p.Ser177Phe	missense variant	-	NC_000012.12:g.52950779C>T	TOPMed
rs1171935393	p.Val178Met	missense variant	-	NC_000012.12:g.52950781G>A	gnomAD
rs774948895	p.Asp181Glu	missense variant	-	NC_000012.12:g.52950792C>G	ExAC,TOPMed,gnomAD
rs762675185	p.Ile182Thr	missense variant	-	NC_000012.12:g.52950794T>C	ExAC,TOPMed,gnomAD
rs1421413412	p.Leu185Phe	missense variant	-	NC_000012.12:g.52950802C>T	gnomAD
rs773737254	p.Arg186His	missense variant	-	NC_000012.12:g.52950806G>A	ExAC,TOPMed,gnomAD
rs772530106	p.Arg186Cys	missense variant	-	NC_000012.12:g.52950805C>T	ExAC,TOPMed,gnomAD
rs1295633602	p.Val188Ile	missense variant	-	NC_000012.12:g.52950811G>A	gnomAD
rs1274432464	p.Asp190Tyr	missense variant	-	NC_000012.12:g.52950817G>T	TOPMed
rs1434595201	p.Asn193Ser	missense variant	-	NC_000012.12:g.52950827A>G	TOPMed
rs11170343	p.Asn193Asp	missense variant	-	NC_000012.12:g.52950826A>G	ExAC,gnomAD
rs1329069794	p.Thr195Ile	missense variant	-	NC_000012.12:g.52950833C>T	TOPMed
rs903529010	p.Arg196Gln	missense variant	-	NC_000012.12:g.52950836G>A	TOPMed,gnomAD
rs146788536	p.Glu200Gly	missense variant	-	NC_000012.12:g.52950848A>G	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu202Ter	stop gained	-	NC_000012.12:g.52950853G>T	NCI-TCGA
rs1296302277	p.Ile203Phe	missense variant	-	NC_000012.12:g.52950856A>T	TOPMed
rs770760404	p.Ile203Ser	missense variant	-	NC_000012.12:g.52950857T>G	ExAC,TOPMed,gnomAD
rs1467314647	p.Glu204Lys	missense variant	-	NC_000012.12:g.52950859G>A	gnomAD
COSM4831855	p.Glu204Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52950859G>C	NCI-TCGA Cosmic
rs1213240462	p.Glu204Gly	missense variant	-	NC_000012.12:g.52950860A>G	gnomAD
rs1171566992	p.Ala205Thr	missense variant	-	NC_000012.12:g.52950862G>A	TOPMed
COSM299289	p.Ala205Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52950863C>T	NCI-TCGA Cosmic
rs542816796	p.Lys207Arg	missense variant	-	NC_000012.12:g.52950869A>G	1000Genomes,TOPMed
rs1488193972	p.Glu208Val	missense variant	-	NC_000012.12:g.52950872A>T	TOPMed
NCI-TCGA novel	p.Glu209Lys	missense variant	-	NC_000012.12:g.52950874G>A	NCI-TCGA
NCI-TCGA novel	p.Phe212Ser	missense variant	-	NC_000012.12:g.52950884T>C	NCI-TCGA
rs1213666438	p.Met213Thr	missense variant	-	NC_000012.12:g.52950887T>C	TOPMed
rs1416055882	p.Asn216Ser	missense variant	-	NC_000012.12:g.52950896A>G	gnomAD
rs375823747	p.Glu218Lys	missense variant	-	NC_000012.12:g.52950901G>A	ESP,ExAC,TOPMed,gnomAD
rs531597374	p.Glu219Gly	missense variant	-	NC_000012.12:g.52950905A>G	1000Genomes,ExAC,gnomAD
rs760118857	p.Lys222Glu	missense variant	-	NC_000012.12:g.52951487A>G	ExAC,gnomAD
rs752798433	p.Gly223Asp	missense variant	-	NC_000012.12:g.52951491G>A	ExAC,gnomAD
rs765181291	p.Gly223Ser	missense variant	-	NC_000012.12:g.52951490G>A	ExAC,gnomAD
rs1311227284	p.Ala226Val	missense variant	-	NC_000012.12:g.52951500C>T	TOPMed
rs763059508	p.Ala226Thr	missense variant	-	NC_000012.12:g.52951499G>A	ExAC,TOPMed,gnomAD
rs1312796330	p.Gln227Pro	missense variant	-	NC_000012.12:g.52951503A>C	gnomAD
rs11551639	p.Ile228Met	missense variant	-	NC_000012.12:g.52951507T>G	-
rs764298430	p.Ile228Thr	missense variant	-	NC_000012.12:g.52951506T>C	ExAC,gnomAD
rs1278862013	p.Ala229Pro	missense variant	-	NC_000012.12:g.52951508G>C	gnomAD
rs58472472	p.Ser230Thr	missense variant	-	NC_000012.12:g.52951512G>C	UniProt,dbSNP
VAR_023055	p.Ser230Thr	missense variant	-	NC_000012.12:g.52951512G>C	UniProt
rs58472472	p.Ser230Thr	missense variant	-	NC_000012.12:g.52951512G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000056439	p.Ser230Thr	missense variant	-	NC_000012.12:g.52951512G>C	ClinVar
rs1048221713	p.Ser231Pro	missense variant	-	NC_000012.12:g.52951514T>C	TOPMed,gnomAD
rs756101711	p.Val235Met	missense variant	-	NC_000012.12:g.52951526G>A	ExAC,gnomAD
COSM1719322	p.Glu236Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52951529G>A	NCI-TCGA Cosmic
rs779909524	p.Asp238Glu	missense variant	-	NC_000012.12:g.52951537T>G	ExAC,gnomAD
rs779909524	p.Asp238Glu	missense variant	-	NC_000012.12:g.52951537T>A	ExAC,gnomAD
COSM3871922	p.Asp238Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52951535G>A	NCI-TCGA Cosmic
rs1174953357	p.Lys241Arg	missense variant	-	NC_000012.12:g.52951545A>G	TOPMed,gnomAD
rs1174953357	p.Lys241Thr	missense variant	-	NC_000012.12:g.52951545A>C	TOPMed,gnomAD
NCI-TCGA novel	p.Ser242Tyr	missense variant	-	NC_000012.12:g.52951548C>A	NCI-TCGA
rs1303490294	p.Asp244Val	missense variant	-	NC_000012.12:g.52951554A>T	TOPMed
rs748780372	p.Ala246Thr	missense variant	-	NC_000012.12:g.52951559G>A	ExAC,TOPMed,gnomAD
COSM1299562	p.Ala246Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52951560C>A	NCI-TCGA Cosmic
rs1318727866	p.Lys247Arg	missense variant	-	NC_000012.12:g.52951563A>G	gnomAD
rs1173135661	p.Ile248Thr	missense variant	-	NC_000012.12:g.52951566T>C	TOPMed
rs191325805	p.Met249Ile	missense variant	-	NC_000012.12:g.52951570G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs778646111	p.Ala250Thr	missense variant	-	NC_000012.12:g.52951571G>A	ExAC,gnomAD
NCI-TCGA novel	p.Ile252Val	missense variant	-	NC_000012.12:g.52951577A>G	NCI-TCGA
rs747804954	p.Arg253Gln	missense variant	-	NC_000012.12:g.52951581G>A	ExAC,TOPMed,gnomAD
COSM3398837	p.Arg253Trp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52951580C>T	NCI-TCGA Cosmic
rs1347876514	p.Glu258Lys	missense variant	-	NC_000012.12:g.52951595G>A	TOPMed,gnomAD
rs925098058	p.Ala260Pro	missense variant	-	NC_000012.12:g.52951601G>C	TOPMed
RCV000056440	p.Arg261Gln	missense variant	-	NC_000012.12:g.52951605G>A	ClinVar
rs57354642	p.Arg261Gln	missense variant	Cirrhosis (CIRRH)	NC_000012.12:g.52951605G>A	UniProt,dbSNP
VAR_023056	p.Arg261Gln	missense variant	Cirrhosis (CIRRH)	NC_000012.12:g.52951605G>A	UniProt
rs57354642	p.Arg261Gln	missense variant	-	NC_000012.12:g.52951605G>A	ExAC,TOPMed,gnomAD
rs776044211	p.Arg261Trp	missense variant	-	NC_000012.12:g.52951604C>T	ExAC,TOPMed,gnomAD
rs11551643	p.Asn263Lys	missense variant	-	NC_000012.12:g.52951612C>G	ESP,ExAC,TOPMed,gnomAD
rs774491952	p.Arg264Ter	stop gained	-	NC_000012.12:g.52951613C>T	ExAC,gnomAD
rs762129501	p.Arg264Gln	missense variant	-	NC_000012.12:g.52951614G>A	ExAC,TOPMed,gnomAD
rs767170853	p.Glu265Asp	missense variant	-	NC_000012.12:g.52951618G>C	ExAC,gnomAD
NCI-TCGA novel	p.Glu266Val	missense variant	-	NC_000012.12:g.52951620A>T	NCI-TCGA
rs1217251308	p.Asp268Glu	missense variant	-	NC_000012.12:g.52951627C>A	TOPMed
rs755905707	p.Asp268Gly	missense variant	-	NC_000012.12:g.52951626A>G	ExAC,gnomAD
rs766324065	p.Lys269Asn	missense variant	-	NC_000012.12:g.52951630G>C	ExAC,gnomAD
rs1314118024	p.Ser272Phe	missense variant	-	NC_000012.12:g.52951638C>T	TOPMed
COSM1299563	p.Ile275Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52951733T>G	NCI-TCGA Cosmic
rs565940319	p.Ile275Thr	missense variant	-	NC_000012.12:g.52951732T>C	1000Genomes,ExAC,TOPMed,gnomAD
rs61696408	p.Glu276Gly	missense variant	-	NC_000012.12:g.52951735A>G	-
COSM3812345	p.Glu276Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52951734G>C	NCI-TCGA Cosmic
RCV000056441	p.Glu276Gly	missense variant	-	NC_000012.12:g.52951735A>G	ClinVar
NCI-TCGA novel	p.Glu277Gln	missense variant	-	NC_000012.12:g.52951737G>C	NCI-TCGA
rs766276909	p.Val281Leu	missense variant	-	NC_000012.12:g.52951749G>C	ExAC,gnomAD
rs754985586	p.Val282Phe	missense variant	-	NC_000012.12:g.52951752G>T	ExAC,gnomAD
RCV000056442	p.Gln285Arg	missense variant	-	NC_000012.12:g.52951762A>G	ClinVar
rs59112368	p.Gln285Arg	missense variant	-	NC_000012.12:g.52951762A>G	ExAC,TOPMed,gnomAD
COSM4607556	p.Ser286Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52951765C>A	NCI-TCGA Cosmic
rs1294310136	p.Ala287Val	missense variant	-	NC_000012.12:g.52951768C>T	gnomAD
rs1266499407	p.Ala292Thr	missense variant	-	NC_000012.12:g.52951782G>A	TOPMed
rs1355185338	p.Thr294Met	missense variant	-	NC_000012.12:g.52951789C>T	gnomAD
rs757912166	p.Thr294Ala	missense variant	-	NC_000012.12:g.52951788A>G	ExAC,TOPMed,gnomAD
rs267607418	p.Thr295Met	missense variant	-	NC_000012.12:g.52951792C>T	ESP,ExAC,TOPMed,gnomAD
RCV000056443	p.Thr295Met	missense variant	-	NC_000012.12:g.52951792C>T	ClinVar
rs267607418	p.Thr295Lys	missense variant	-	NC_000012.12:g.52951792C>A	ESP,ExAC,TOPMed,gnomAD
rs1180938510	p.Leu296Pro	missense variant	-	NC_000012.12:g.52951795T>C	gnomAD
RCV000056444	p.Thr297Ile	missense variant	-	NC_000012.12:g.52951798C>T	ClinVar
rs115810585	p.Thr297Ile	missense variant	-	NC_000012.12:g.52951798C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs749749094	p.Arg300Thr	missense variant	-	NC_000012.12:g.52951807G>C	ExAC,gnomAD
rs1185499795	p.Arg300Gly	missense variant	-	NC_000012.12:g.52951806A>G	gnomAD
rs1169724462	p.Arg301His	missense variant	-	NC_000012.12:g.52951810G>A	TOPMed,gnomAD
rs932515816	p.Arg301Cys	missense variant	-	NC_000012.12:g.52951809C>T	gnomAD
rs769132516	p.Thr302Ile	missense variant	-	NC_000012.12:g.52951813C>T	ExAC,gnomAD
rs1457337517	p.Ser305Phe	missense variant	-	NC_000012.12:g.52951822C>T	TOPMed
rs779439842	p.Ser305Thr	missense variant	-	NC_000012.12:g.52951821T>A	ExAC,TOPMed,gnomAD
rs779439842	p.Ser305Pro	missense variant	-	NC_000012.12:g.52951821T>C	ExAC,TOPMed,gnomAD
rs748258071	p.Ile308Phe	missense variant	-	NC_000012.12:g.52951830A>T	ExAC,TOPMed,gnomAD
rs149270992	p.Ile308Met	missense variant	-	NC_000012.12:g.52951832C>G	ESP,ExAC,TOPMed,gnomAD
rs199930351	p.Asp309Asn	missense variant	-	NC_000012.12:g.52951833G>A	ExAC,TOPMed,gnomAD
rs199930351	p.Asp309His	missense variant	-	NC_000012.12:g.52951833G>C	ExAC,TOPMed,gnomAD
rs760836025	p.Ser312Pro	missense variant	-	NC_000012.12:g.52951842T>C	ExAC,gnomAD
rs1382465483	p.Lys317Arg	missense variant	-	NC_000012.12:g.52952120A>G	gnomAD
COSM5163397	p.Lys317Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52952119A>G	NCI-TCGA Cosmic
rs1324297627	p.Ala318Val	missense variant	-	NC_000012.12:g.52952123C>T	gnomAD
rs961254162	p.Ser319Arg	missense variant	-	NC_000012.12:g.52952127C>G	gnomAD
rs1227105377	p.Ser319Gly	missense variant	-	NC_000012.12:g.52952125A>G	gnomAD
rs1303493962	p.Ser319Asn	missense variant	-	NC_000012.12:g.52952126G>A	gnomAD
COSM4918592	p.Leu324Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52952141T>A	NCI-TCGA Cosmic
rs569786087	p.Leu324Met	missense variant	-	NC_000012.12:g.52952140C>A	ExAC,TOPMed,gnomAD
rs554733127	p.Arg325Lys	missense variant	-	NC_000012.12:g.52952144G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1206645651	p.Glu326Gln	missense variant	-	NC_000012.12:g.52952146G>C	gnomAD
rs1206645651	p.Glu326Lys	missense variant	-	NC_000012.12:g.52952146G>A	gnomAD
rs1479626216	p.Val327Met	missense variant	-	NC_000012.12:g.52952149G>A	TOPMed
rs1194423970	p.Ala329Val	missense variant	-	NC_000012.12:g.52952156C>T	gnomAD
rs147365823	p.Arg330Cys	missense variant	-	NC_000012.12:g.52952158C>T	ESP,ExAC,TOPMed,gnomAD
rs755405944	p.Arg330His	missense variant	-	NC_000012.12:g.52952159G>A	ExAC,TOPMed,gnomAD
rs748604274	p.Ala332Thr	missense variant	-	NC_000012.12:g.52952164G>A	ExAC,gnomAD
rs777734597	p.Met335Arg	missense variant	-	NC_000012.12:g.52952174T>G	ExAC,TOPMed,gnomAD
rs1382413504	p.Met335Leu	missense variant	-	NC_000012.12:g.52952173A>T	gnomAD
rs777734597	p.Met335Thr	missense variant	-	NC_000012.12:g.52952174T>C	ExAC,TOPMed,gnomAD
rs1326009340	p.Glu336Lys	missense variant	-	NC_000012.12:g.52952176G>A	gnomAD
rs57370769	p.Gly340Arg	missense variant	Cirrhosis (CIRRH)	NC_000012.12:g.52952188G>A	UniProt,dbSNP
VAR_023057	p.Gly340Arg	missense variant	Cirrhosis (CIRRH)	NC_000012.12:g.52952188G>A	UniProt
rs57370769	p.Gly340Arg	missense variant	-	NC_000012.12:g.52952188G>A	ESP,ExAC,TOPMed,gnomAD
RCV000056431	p.Gly340Arg	missense variant	-	NC_000012.12:g.52952188G>A	ClinVar
rs1300560482	p.Leu342Val	missense variant	-	NC_000012.12:g.52952194C>G	gnomAD
rs1317426104	p.Leu342Pro	missense variant	-	NC_000012.12:g.52952195T>C	gnomAD
rs143380812	p.Glu346Lys	missense variant	-	NC_000012.12:g.52952206G>A	ESP,ExAC,TOPMed,gnomAD
rs1254987867	p.Glu348Gln	missense variant	-	NC_000012.12:g.52952212G>C	gnomAD
rs1321070806	p.Leu349Arg	missense variant	-	NC_000012.12:g.52952216T>G	TOPMed
rs1467228032	p.Gln351His	missense variant	-	NC_000012.12:g.52952223G>C	gnomAD
rs1190661327	p.Thr352Ile	missense variant	-	NC_000012.12:g.52952225C>T	TOPMed,gnomAD
rs1421391734	p.Arg353Gly	missense variant	-	NC_000012.12:g.52952227C>G	TOPMed,gnomAD
rs769726300	p.Arg353Gln	missense variant	-	NC_000012.12:g.52952228G>A	ExAC,gnomAD
rs1421391734	p.Arg353Trp	missense variant	-	NC_000012.12:g.52952227C>T	TOPMed,gnomAD
rs543607490	p.Ala354Glu	missense variant	-	NC_000012.12:g.52952231C>A	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Ala354Val	missense variant	-	NC_000012.12:g.52952231C>T	NCI-TCGA
rs1456394601	p.Gln357Leu	missense variant	-	NC_000012.12:g.52952240A>T	TOPMed,gnomAD
rs1456394601	p.Gln357Arg	missense variant	-	NC_000012.12:g.52952240A>G	TOPMed,gnomAD
rs762831521	p.Arg358His	missense variant	-	NC_000012.12:g.52952243G>A	ExAC,TOPMed,gnomAD
rs763612705	p.Ala360Val	missense variant	-	NC_000012.12:g.52952249C>T	ExAC,TOPMed,gnomAD
rs1459462925	p.Gln361Ter	stop gained	-	NC_000012.12:g.52952251C>T	gnomAD
rs1292425055	p.Gln361His	missense variant	-	NC_000012.12:g.52952253G>C	TOPMed,gnomAD
NCI-TCGA novel	p.Gln361ProPheSerTerUnk	frameshift	-	NC_000012.12:g.52952248_52952249insC	NCI-TCGA
COSM3368858	p.Glu362Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52952254G>A	NCI-TCGA Cosmic
rs1392999290	p.Tyr363Phe	missense variant	-	NC_000012.12:g.52952258A>T	gnomAD
rs1234167038	p.Ile369Val	missense variant	-	NC_000012.12:g.52952275A>G	gnomAD
rs1332941249	p.Val371Ile	missense variant	-	NC_000012.12:g.52952281G>A	gnomAD
rs1221009613	p.Lys372Asn	missense variant	-	NC_000012.12:g.52952286G>T	gnomAD
rs1251892578	p.Leu373Pro	missense variant	-	NC_000012.12:g.52952288T>C	gnomAD
rs750137340	p.Glu374Gly	missense variant	-	NC_000012.12:g.52952291A>G	ExAC,gnomAD
rs1175939678	p.Ala375Thr	missense variant	-	NC_000012.12:g.52952293G>A	gnomAD
rs1419656440	p.Ala378Val	missense variant	-	NC_000012.12:g.52952303C>T	gnomAD
COSM296494	p.Ala378Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52952302G>T	NCI-TCGA Cosmic
rs753197079	p.Ala378Thr	missense variant	-	NC_000012.12:g.52952302G>A	ExAC,gnomAD
rs1163469093	p.Thr379Ile	missense variant	-	NC_000012.12:g.52952306C>T	TOPMed,gnomAD
rs1163469093	p.Thr379Ser	missense variant	-	NC_000012.12:g.52952306C>G	TOPMed,gnomAD
rs1044002535	p.Arg381Ser	missense variant	-	NC_000012.12:g.52952311C>A	gnomAD
rs147541172	p.Arg381His	missense variant	-	NC_000012.12:g.52952312G>A	ESP,ExAC,TOPMed,gnomAD
rs1044002535	p.Arg381Cys	missense variant	-	NC_000012.12:g.52952311C>T	gnomAD
rs770506633	p.Arg382Leu	missense variant	-	NC_000012.12:g.52952315G>T	TOPMed,gnomAD
rs770506633	p.Arg382His	missense variant	-	NC_000012.12:g.52952315G>A	TOPMed,gnomAD
rs11551627	p.Arg382Ser	missense variant	-	NC_000012.12:g.52952314C>A	ExAC,TOPMed,gnomAD
rs11551627	p.Arg382Cys	missense variant	-	NC_000012.12:g.52952314C>T	ExAC,TOPMed,gnomAD
rs757469736	p.Gly387Asp	missense variant	-	NC_000012.12:g.52952330G>A	ExAC,TOPMed,gnomAD
rs999709039	p.Glu388Asp	missense variant	-	NC_000012.12:g.52952334G>T	TOPMed
rs746093574	p.Glu388Lys	missense variant	-	NC_000012.12:g.52952332G>A	ExAC,TOPMed,gnomAD
rs1202485697	p.Asp389Asn	missense variant	-	NC_000012.12:g.52952335G>A	gnomAD
rs1274618434	p.Phe390Ser	missense variant	-	NC_000012.12:g.52952339T>C	gnomAD
rs769672516	p.Asn391His	missense variant	-	NC_000012.12:g.52952341A>C	ExAC,gnomAD
rs903196253	p.Gly393Asp	missense variant	-	NC_000012.12:g.52952727G>A	TOPMed,gnomAD
rs781454348	p.Leu396Ser	missense variant	-	NC_000012.12:g.52952736T>C	ExAC,gnomAD
rs1433088298	p.Asn400Asp	missense variant	-	NC_000012.12:g.52952747A>G	gnomAD
rs1197102047	p.Ser401Ala	missense variant	-	NC_000012.12:g.52952750T>G	TOPMed
rs746040565	p.Met402Val	missense variant	-	NC_000012.12:g.52952753A>G	ExAC,gnomAD
rs1478754941	p.Thr404Ile	missense variant	-	NC_000012.12:g.52952760C>T	TOPMed
rs1371758556	p.Thr404Ala	missense variant	-	NC_000012.12:g.52952759A>G	gnomAD
rs1443796983	p.Ile405Val	missense variant	-	NC_000012.12:g.52952762A>G	gnomAD
rs1273623198	p.Ile405Thr	missense variant	-	NC_000012.12:g.52952763T>C	gnomAD
rs1000629681	p.Lys407Glu	missense variant	-	NC_000012.12:g.52952768A>G	TOPMed,gnomAD
rs1484619017	p.Thr408Ile	missense variant	-	NC_000012.12:g.52952772C>T	TOPMed
rs780366176	p.Thr410Asn	missense variant	-	NC_000012.12:g.52952778C>A	ExAC,TOPMed,gnomAD
rs780366176	p.Thr410Ile	missense variant	-	NC_000012.12:g.52952778C>T	ExAC,TOPMed,gnomAD
rs780366176	p.Thr410Ser	missense variant	-	NC_000012.12:g.52952778C>G	ExAC,TOPMed,gnomAD
RCV000056432	p.Arg411His	missense variant	-	NC_000012.12:g.52952781G>A	ClinVar
rs768557036	p.Arg411Cys	missense variant	-	NC_000012.12:g.52952780C>T	ExAC,TOPMed,gnomAD
rs148580152	p.Arg411His	missense variant	-	NC_000012.12:g.52952781G>A	ESP,TOPMed,gnomAD
rs146080391	p.Arg412Gln	missense variant	-	NC_000012.12:g.52952784G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs774101880	p.Arg412Trp	missense variant	-	NC_000012.12:g.52952783C>T	ExAC,gnomAD
rs1244966651	p.Ile413Thr	missense variant	-	NC_000012.12:g.52952787T>C	gnomAD
rs1477656651	p.Ile413Met	missense variant	-	NC_000012.12:g.52952788A>G	gnomAD
rs771518602	p.Gly416Asp	missense variant	-	NC_000012.12:g.52952796G>A	ExAC,TOPMed,gnomAD
rs772684603	p.Val418Leu	missense variant	-	NC_000012.12:g.52952801G>T	ExAC,gnomAD
rs765942310	p.Val419Glu	missense variant	-	NC_000012.12:g.52952805T>A	ExAC,gnomAD
NCI-TCGA novel	p.Glu421Gln	missense variant	-	NC_000012.12:g.52952810G>C	NCI-TCGA
rs200552337	p.Asn423Ser	missense variant	-	NC_000012.12:g.52952817A>G	ESP,ExAC,TOPMed,gnomAD
COSM4042953	p.Asp424Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.52952819G>T	NCI-TCGA Cosmic
rs1331038097	p.Lys426Glu	missense variant	-	NC_000012.12:g.52952825A>G	gnomAD
rs763169289	p.Leu428Pro	missense variant	-	NC_000012.12:g.52952832T>C	ExAC,gnomAD
rs1303579109	p.His430Asn	missense variant	-	NC_000012.12:g.52952837C>A	TOPMed

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0000768	Congenital Abnormality	group	BEFREE
C0000889	Acanthosis Nigricans	disease	BEFREE
C0001418	Adenocarcinoma	group	BEFREE;LHGDN
C0002793	Anaplasia	disease	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE;CTD_human
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE
C0007137	Squamous cell carcinoma	disease	BEFREE;LHGDN
C0008497	Choriocarcinoma	disease	BEFREE
C0008626	Congenital chromosomal disease	group	BEFREE
C0009404	Colorectal Neoplasms	group	BEFREE
C0010674	Cystic Fibrosis	disease	BEFREE
C0014527	Epidermolysis Bullosa	disease	LHGDN
C0015695	Fatty Liver	disease	BEFREE
C0019158	Hepatitis	disease	BEFREE
C0019159	Hepatitis A	disease	BEFREE
C0019189	Hepatitis, Chronic	disease	BEFREE
C0019193	Hepatitis, Toxic	disease	CTD_human
C0019196	Hepatitis C	disease	BEFREE
C0021364	Male infertility	disease	BEFREE
C0021390	Inflammatory Bowel Diseases	group	BEFREE
C0023890	Liver Cirrhosis	disease	BEFREE;CTD_human
C0023893	Liver Cirrhosis, Experimental	disease	CTD_human
C0023895	Liver diseases	group	BEFREE;LHGDN
C0023903	Liver neoplasms	group	CTD_human
C0024291	Lymphohistiocytosis, Hemophagocytic	disease	BEFREE
C0024299	Lymphoma	group	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0027540	Necrosis	phenotype	CTD_human
C0027627	Neoplasm Metastasis	phenotype	BEFREE
C0028754	Obesity	disease	BEFREE
C0028880	Odontogenic Tumors	group	BEFREE
C0029925	Ovarian Carcinoma	disease	BEFREE
C0030920	Peptic Ulcer	disease	BEFREE
C0036631	Seminoma	disease	BEFREE
C0038356	Stomach Neoplasms	group	LHGDN
C0039538	Teratoma	disease	LHGDN
C0149521	Pancreatitis, Chronic	disease	BEFREE
C0149925	Small cell carcinoma of lung	disease	BEFREE
C0162557	Liver Failure, Acute	disease	BEFREE;CTD_human
C0178874	Tumor Progression	phenotype	BEFREE
C0206623	Adenosquamous carcinoma	disease	BEFREE
C0206659	Embryonal Carcinoma	disease	BEFREE
C0206698	Cholangiocarcinoma	disease	BEFREE
C0206723	Sertoli-Leydig Cell Tumor	disease	BEFREE
C0235884	Perforation of stomach	disease	BEFREE
C0235974	Pancreatic carcinoma	disease	BEFREE
C0239946	Fibrosis, Liver	disease	BEFREE;CTD_human
C0241910	Hepatitis, Autoimmune	disease	LHGDN
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0267809	Cirrhosis, Cryptogenic	disease	BEFREE;CLINVAR;UNIPROT
C0268074	Indian childhood cirrhosis	disease	UNIPROT
C0334619	HODGKIN'S AND NON-HODGKIN'S LYMPHOMA	disease	BEFREE
C0345904	Malignant neoplasm of liver	disease	CTD_human
C0346647	Malignant neoplasm of pancreas	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0524909	Hepatitis B, Chronic	disease	BEFREE
C0524910	Hepatitis C, Chronic	disease	BEFREE;LHGDN
C0600139	Prostate carcinoma	disease	BEFREE
C0677886	Epithelial ovarian cancer	disease	BEFREE
C0677944	Sentinel node (disorder)	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE;CTD_human
C0684249	Carcinoma of lung	disease	BEFREE
C0686619	Secondary malignant neoplasm of lymph node	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0745744	End Stage Liver Disease	disease	BEFREE
C0860207	Drug-Induced Liver Disease	disease	CTD_human
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1176475	Ductal Carcinoma	disease	LHGDN
C1257931	Mammary Neoplasms, Human	group	CTD_human
C1262760	Hepatitis, Drug-Induced	disease	CTD_human
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1458155	Mammary Neoplasms	group	CTD_human;LHGDN
C1835713	CIRRHOSIS, NONCRYPTOGENIC, SUSCEPTIBILITY TO (finding)	phenotype	CLINVAR;UNIPROT
C1855038	Hepatocellular necrosis	disease	BEFREE
C1859088	COPPER TOXICOSIS, IDIOPATHIC	disease	UNIPROT
C1861556	Cirrhosis, Familial	disease	UNIPROT
C1876165	Copper-Overload Cirrhosis	disease	UNIPROT
C1876166	Endemic Tyrolean Infantile Cirrhosis	disease	UNIPROT
C2239176	Liver carcinoma	disease	BEFREE;LHGDN
C2711227	Steatohepatitis	disease	BEFREE
C2986665	Early-Stage Breast Carcinoma	disease	BEFREE
C3241937	Nonalcoholic Steatohepatitis	disease	BEFREE
C3642345	Luminal A Breast Carcinoma	disease	BEFREE
C3642346	Luminal B Breast Carcinoma	disease	BEFREE
C3658290	Drug-Induced Acute Liver Injury	disease	CTD_human
C4277682	Chemical and Drug Induced Liver Injury	disease	CTD_human
C4279912	Chemically-Induced Liver Toxicity	disease	CTD_human

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0003723	RNA binding	HDA
GO:0005198	structural molecule activity	IEA
GO:0005515	protein binding	IPI
GO:0097110	scaffold protein binding	IPI
GO:0098641	cadherin binding involved in cell-cell adhesion	HDA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0007049	cell cycle	IEA
GO:0009653	anatomical structure morphogenesis	TAS
GO:0016032	viral process	IEA
GO:0031424	keratinization	TAS
GO:0033209	tumor necrosis factor-mediated signaling pathway	IEA
GO:0043000	Golgi to plasma membrane CFTR protein transport	IDA
GO:0043066	negative regulation of apoptotic process	IDA
GO:0045104	intermediate filament cytoskeleton organization	IDA
GO:0070268	cornification	TAS
GO:0097191	extrinsic apoptotic signaling pathway	IEA
GO:0097284	hepatocyte apoptotic process	IEA
GO:0098609	cell-cell adhesion	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005730	nucleolus	IEA
GO:0005737	cytoplasm	IDA
GO:0005815	microtubule organizing center	IDA
GO:0005829	cytosol	IDA
GO:0005829	cytosol	TAS
GO:0005882	intermediate filament	IDA
GO:0005912	adherens junction	HDA
GO:0034451	centriolar satellite	IDA
GO:0045095	keratin filament	IDA
GO:0048471	perinuclear region of cytoplasm	IEA
GO:0070062	extracellular exosome	HDA
GO:0071944	cell periphery	IEA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-6805567	Keratinization	TAS
R-HSA-6809371	Formation of the cornified envelope	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C031763	1,3-butadiene	1,3-butadiene results in decreased expression of KRT18 mRNA	21147608
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of KRT18 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of KRT18 mRNA	28628672
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of KRT18 mRNA	15913567
D015058	1-Naphthylisothiocyanate	O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of KRT18 mRNA]	15913567
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of KRT18 mRNA	17522070; 25380136; 30723492;
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene affects the expression of KRT18 mRNA	21346803
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene affects the expression of KRT18 mRNA	21346803
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of KRT18 mRNA	25088246
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of KRT18 mRNA]	11179685
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of KRT18 mRNA	28973690
C530773	3,5-diethoxycarbonyl-1,4-dihydrocollidine	3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT18 mRNA	10751352
C496751	4-(1H-imidazol-1-yl)retinoic acid	4-(1H-imidazol-1-yl)retinoic acid results in increased expression of KRT18 protein	17145897; 17387344;
C496751	4-(1H-imidazol-1-yl)retinoic acid	4-(1H-imidazol-1-yl)retinoic acid results in increased expression of KRT18 protein	17145897
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of KRT18 mRNA	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of KRT18 protein	25670856
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of KRT18 mRNA	20852150
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of KRT18 protein	20852150
C035207	4-amino-2,6-dinitrotoluene	4-amino-2,6-dinitrotoluene affects the expression of KRT18 mRNA	21346803
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of KRT18 mRNA	17034753
C041819	4-oxoretinol	4-oxoretinol results in increased expression of KRT18 mRNA	17034753
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene results in increased expression of KRT18 mRNA	22485181
C501332	ABT-737	ABT-737 results in increased cleavage of KRT18 protein	19010845
D000082	Acetaminophen	Acetaminophen results in decreased expression of KRT18 mRNA	21420995
D000082	Acetaminophen	KRT18 protein results in decreased susceptibility to Acetaminophen	8770877
D000082	Acetaminophen	Acetaminophen affects the expression of KRT18 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased cleavage of KRT18 protein	19783637
D000082	Acetaminophen	Acetaminophen results in increased expression of KRT18 protein	22939915
D000082	Acetaminophen	dioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]	22939915
D000171	Acrolein	Acrolein results in increased metabolism of KRT18 protein	20015449
D000077556	Alitretinoin	Alitretinoin results in increased expression of KRT18 mRNA	17034753
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin affects the expression of KRT18 protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog affects the expression of KRT18 protein	26597043
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of KRT18 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of KRT18 protein	16483693
C059765	amphotericin B, deoxycholate drug combination	amphotericin B, deoxycholate drug combination results in increased expression of KRT18 mRNA	22863853
D016718	Arachidonic Acid	[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein	17034788
D001151	Arsenic	Arsenic affects the methylation of KRT18 gene	25304211
D001151	Arsenic	Arsenic results in decreased expression of KRT18 mRNA	11134558; 12773770;
D000077237	Arsenic Trioxide	KRT18 protein results in decreased susceptibility to Arsenic Trioxide	20707922
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of KRT18 mRNA	15073043
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in decreased expression of KRT18 mRNA	29523930
D001280	Atrazine	Atrazine affects the methylation of KRT18 gene	28931070
D001507	Beclomethasone	Beclomethasone results in increased expression of KRT18 mRNA	23656298
C487081	belinostat	belinostat results in increased expression of KRT18 mRNA	26272509
C487081	belinostat	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KRT18 mRNA	22209252
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of KRT18 mRNA	31255691
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KRT18 mRNA	20064835; 26238291;
D001564	Benzo(a)pyrene	[Soot co-treated with Benzo(a)pyrene] results in decreased expression of KRT18 protein modified form	24464499
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to KRT18 promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of KRT18 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KRT18 mRNA	27195522
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KRT18 protein	21467743
D019207	beta Carotene	beta Carotene results in increased expression of KRT18 mRNA	17034753
D001647	Bile Acids and Salts	Bile Acids and Salts results in increased expression of KRT18 protein	21127259
C519495	BIM 23120	[BIM 23120 results in increased activity of SSTR2 protein] which results in increased expression of KRT18 protein modified form	16954443
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of KRT18 mRNA	30951980
C006780	bisphenol A	bisphenol A affects the expression of KRT18 mRNA	30903817
C006780	bisphenol A	bisphenol A results in decreased expression of KRT18 mRNA	27685785
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of KRT18 mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of KRT18 mRNA	30951980
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of KRT18 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of KRT18 mRNA	25181051
C000611646	bisphenol F	[bisphenol F co-treated with Tretinoin] results in decreased expression of KRT18 mRNA	30951980
C000611646	bisphenol F	bisphenol F results in increased expression of KRT18 mRNA	30951980
C022777	bufalin	bufalin results in increased expression of KRT18 protein	23091618
D002065	Buspirone	Buspirone results in decreased expression of KRT18 mRNA	24136188
D002085	Butylhydroxybutylnitrosamine	Butylhydroxybutylnitrosamine results in decreased expression of KRT18 protein	24998975
D002101	Cacodylic Acid	Cacodylic Acid results in decreased expression of KRT18 mRNA	17481689
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of KRT18 mRNA	23828170
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of KRT18 mRNA	12160620
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of KRT18 mRNA	18804290
D002110	Caffeine	Caffeine results in decreased expression of KRT18 protein	31195006
D002117	Calcitriol	Calcitriol results in increased expression of KRT18 mRNA	26485663
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of KRT18 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of KRT18 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of KRT18 mRNA	17522070; 31150632;
D002251	Carbon Tetrachloride	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of KRT18 mRNA]	31150632
D007631	Chlordecone	Chlordecone results in increased expression of KRT18 mRNA	29458080
D002725	Chloroform	Chloroform results in increased expression of KRT18 mRNA	17522070
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of KRT18 mRNA	21356183
C041167	chromium nitrate	chromium nitrate results in decreased expression of KRT18 protein	22144121
C418118	CI 1044	CI 1044 results in increased expression of KRT18 mRNA	17569694
D002922	Ciguatoxins	Ciguatoxins affects the expression of KRT18 mRNA	18353800
D002994	Clofibrate	Clofibrate results in decreased expression of KRT18 protein	19952500
D002994	Clofibrate	Clofibrate results in decreased expression of KRT18 mRNA	17522070
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [Ethanol results in increased expression of KRT18 protein modified form]	24946281
C018021	cobaltous chloride	cobaltous chloride results in increased expression of KRT18 mRNA	24612858
D003078	Colchicine	Colchicine results in decreased expression of KRT18 protein	11259854
D019327	Copper Sulfate	Copper Sulfate results in increased expression of KRT18 mRNA	19549813
C015763	cumene	[cumene co-treated with KRAS gene mutant form] results in decreased expression of KRT18 mRNA	18648096
D003471	Cuprizone	Cuprizone results in increased expression of KRT18 mRNA	26577399
C057862	cyanoginosin LR	cyanoginosin LR results in increased phosphorylation of KRT18 protein	22960429
C057862	cyanoginosin LR	SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of KRT18 protein]	22960429
C057862	cyanoginosin LR	U 0126 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of KRT18 protein]	22960429
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of KRT18 mRNA	17654400
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of KRT18 mRNA	24921660
D003634	DDT	DDT results in decreased expression of KRT18 protein	26186133
C107676	deguelin	deguelin inhibits the reaction [TGFB1 protein results in decreased expression of KRT18 protein]	22986522
C107676	deguelin	deguelin results in increased expression of KRT18 protein	22986522
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of KRT18 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of KRT18 mRNA	28628672
D003976	Diazinon	Diazinon results in decreased expression of KRT18 mRNA	29108742
C041517	dibenzo(a,l)pyrene	dibenzo(a,l)pyrene results in decreased expression of KRT18 mRNA	31255691
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of KRT18 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of KRT18 mRNA	28962523
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of KRT18 protein	26186133
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of KRT18 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in increased expression of KRT18 mRNA	22609946
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of KRT18 mRNA	31163220
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of KRT18 protein	20101389
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of KRT18 protein	18978307
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of KRT18 mRNA	19409407
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of KRT18 protein	19409407
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of KRT18 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of KRT18 protein	20935162
D004052	Diethylnitrosamine	[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of KRT18 protein	20935162
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of KRT18 mRNA	25242112
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of KRT18 mRNA	15171707
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of KRT18 mRNA	29581250
D004112	Dimercaprol	Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of KRT18 mRNA]	16377760
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of KRT18 mRNA	17072980; 25380136;
C019357	dioscin	dioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]	22939915
C019357	dioscin	dioscin inhibits the reaction [Ethanol results in increased expression of KRT18 protein]	24146112
D004147	Dioxins	Dioxins affects the expression of KRT18 mRNA	20463971
D004237	Diuron	Diuron results in decreased expression of KRT18 mRNA	21551480
D000077143	Docetaxel	Docetaxel results in increased expression of KRT18 protein	16685278
D000077143	Docetaxel	Docetaxel results in increased metabolism of KRT18 protein	16685278
C516138	dorsomorphin	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
D004317	Doxorubicin	Doxorubicin affects the expression of KRT18 protein	29385562
D004317	Doxorubicin	Doxorubicin results in increased expression of KRT18 mRNA	29803840
D004317	Doxorubicin	KRT18 protein affects the susceptibility to Doxorubicin	16928833
C070609	EMD 53998	EMD 53998 analog results in decreased expression of KRT18 mRNA	24977338
C118739	entinostat	entinostat results in increased expression of KRT18 mRNA	26272509
C118739	entinostat	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of KRT18 mRNA	17522070
D004958	Estradiol	Estradiol affects the expression of KRT18 mRNA	23557687
D004958	Estradiol	3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of KRT18 mRNA]	11179685
D004958	Estradiol	Estradiol results in decreased expression of KRT18 mRNA	23019147
D004958	Estradiol	Estradiol results in increased expression of KRT18 mRNA	11179685; 19484750;
D004958	Estradiol	KRT18 protein promotes the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]	20061804
D004958	Estradiol	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of KRT18 mRNA]	11179685
D004958	Estradiol	Estradiol results in increased expression of KRT18 mRNA	19484750
D004961	Estramustine	Estramustine results in increased expression of KRT18 protein	16685278
D000431	Ethanol	[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein	17034788
D000431	Ethanol	Ethanol results in increased expression of KRT18 protein	20621659
D000431	Ethanol	cobaltiprotoporphyrin inhibits the reaction [Ethanol results in increased expression of KRT18 protein modified form]	24946281
D000431	Ethanol	dioscin inhibits the reaction [Ethanol results in increased expression of KRT18 protein]	24146112
D000431	Ethanol	Ethanol results in increased expression of KRT18 protein	24146112
D000431	Ethanol	Ethanol results in increased expression of KRT18 protein modified form	24946281
D000431	Ethanol	sodium boranocarbonate inhibits the reaction [Ethanol results in increased expression of KRT18 protein modified form]	24946281
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of KRT18 protein	20227414
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of KRT18 mRNA	12655037
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of KRT18 mRNA	23129252
C024565	ethylene dichloride	ethylene dichloride results in increased expression of KRT18 mRNA	28189721
C052498	FEC protocol	FEC protocol results in increased expression of KRT18 protein	17545523
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of KRT18 protein	18978307
D017313	Fenretinide	Fenretinide results in increased expression of KRT18 protein	17387344
D017313	Fenretinide	Fenretinide results in increased expression of KRT18 mRNA	28973697
C020326	ferric nitrilotriacetate	[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein	17034788
D018120	Finasteride	Finasteride results in increased expression of KRT18 mRNA	24136188
C082360	fipronil	fipronil results in decreased expression of KRT18 mRNA	23962444
C043562	flavone	flavone results in decreased expression of KRT18 protein	14750173
D005472	Fluorouracil	[Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased cleavage of KRT18 protein	15754201
D005485	Flutamide	Flutamide results in increased expression of KRT18 mRNA	24136188
D000077267	Fulvestrant	KRT18 protein promotes the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]	20061804
D000077267	Fulvestrant	KRT18 protein promotes the reaction [Fulvestrant results in increased degradation of ESR1 protein]	20061804
C056933	fumonisin B1	fumonisin B1 results in increased expression of KRT18 mRNA	16221962
C039281	furan	furan results in increased expression of KRT18 mRNA	25539665; 26194646;
D019833	Genistein	ESR1 promotes the reaction [Genistein results in increased expression of KRT18 protein]	20884965
D019833	Genistein	ESR2 promotes the reaction [Genistein results in increased expression of KRT18 protein]	20884965
D019833	Genistein	Genistein results in increased expression of KRT18 protein	20884965
D019833	Genistein	Genistein results in increased expression of KRT18 mRNA	24365114
D005897	Glafenine	Glafenine results in increased expression of KRT18 mRNA	24136188
D005978	Glutathione	Glutathione deficiency results in increased expression of KRT18 mRNA	15345336
C004312	glycidol	glycidol results in increased expression of KRT18 mRNA	24395379
D006118	Griseofulvin	Griseofulvin promotes the reaction [KRT18 protein binds to KRT18 protein]	12388748
D006118	Griseofulvin	Griseofulvin results in increased expression of KRT18 mRNA	12388748
D006118	Griseofulvin	KRT18 protein results in decreased susceptibility to Griseofulvin	8770877
D006118	Griseofulvin	Griseofulvin results in increased expression of KRT18 mRNA	10952237; 7504119;
D006118	Griseofulvin	Griseofulvin results in increased expression of KRT18 protein	10952237
C539481	HCV 796	HCV 796 promotes the reaction [CASP3 protein results in increased cleavage of KRT18 protein]	19098685
D006493	Heparin	Heparin results in increased expression of KRT18 protein	15671997
C029424	hydrazine	hydrazine results in increased expression of KRT18 protein	15370871
C492448	ICG 001	ICG 001 results in decreased expression of KRT18 mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of KRT18 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of KRT18 mRNA	28628672
D000077146	Irinotecan	[Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased cleavage of KRT18 protein	15754201
D007545	Isoproterenol	Isoproterenol results in increased expression of KRT18 mRNA	21335049
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of KRT18 mRNA	15476862
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of KRT18 mRNA	27081696
D019344	Lactic Acid	Lactic Acid results in decreased expression of KRT18 mRNA	30851411
D064704	Levofloxacin	Levofloxacin results in decreased expression of KRT18 mRNA	24136188
D008148	Lovastatin	Lovastatin results in decreased expression of KRT18 mRNA	20493250
C042720	mercuric bromide	mercuric bromide results in increased expression of KRT18 mRNA	26272509
C042720	mercuric bromide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of KRT18 protein	21458406
D008701	Methapyrilene	Methapyrilene affects the expression of KRT18 protein	30467583
D008701	Methapyrilene	Methapyrilene results in increased expression of KRT18 mRNA	28935588; 30467583;
D008727	Methotrexate	Methotrexate results in increased expression of KRT18 protein	24736981
D008727	Methotrexate	Methotrexate affects the expression of KRT18 mRNA	18502557
D008748	Methylcholanthrene	Methylcholanthrene affects the expression of KRT18 mRNA	18804290
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of KRT18 mRNA	23458150
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of KRT18 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of KRT18 mRNA	26011545
D008743	Methyl Parathion	Methyl Parathion results in increased expression of KRT18 protein	22182705
D015741	Metribolone	Metribolone results in increased expression of KRT18 protein	17152098; 17541959;
C000622638	MLN7243	MLN7243 results in increased sumoylation of KRT18 protein	31285264
C020300	monomethylarsonic acid	monomethylarsonic acid results in decreased expression of KRT18 mRNA	17481689
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of KRT18 mRNA	26924002
D009151	Mustard Gas	Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of KRT18 mRNA]	16377760
D009151	Mustard Gas	Mustard Gas results in increased expression of KRT18 mRNA	16377760
D037742	Nanotubes, Carbon	Nanotubes, Carbon affects the expression of KRT18 protein	22001959
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of KRT18 mRNA	25554681; 25620056;
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of KRT18 mRNA	25554681
C051752	nefazodone	nefazodone results in increased expression of KRT18 mRNA	24136188
D019829	Nevirapine	Nevirapine results in increased expression of KRT18 protein	19152342
D009532	Nickel	Nickel results in decreased expression of KRT18 mRNA	24768652; 25583101;
C119536	nickel acetate	nickel acetate affects the expression of KRT18 mRNA	23828170
C119536	nickel acetate	nickel acetate affects the expression of KRT18 protein	23828170
D009534	Niclosamide	Niclosamide results in decreased expression of KRT18 mRNA	30165700
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of KRT18 protein	19716841
D009761	Nystatin	Nystatin results in increased expression of KRT18 mRNA	22863853
C107010	O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate	O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of KRT18 mRNA]	15913567
D015282	Octreotide	[Octreotide results in increased activity of SSTR2 protein] which results in increased expression of KRT18 protein modified form	16954443
C005290	oxybenzone	oxybenzone results in decreased expression of KRT18 mRNA	30316929
D010100	Oxygen	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of KRT18 mRNA	30529165
D017239	Paclitaxel	Paclitaxel results in increased expression of KRT18 protein modified form	22907900
D000077767	Panobinostat	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
D000077767	Panobinostat	Panobinostat results in increased expression of KRT18 mRNA	26272509
C016030	pantogab	pantogab results in increased expression of KRT18 mRNA	17379144
D052638	Particulate Matter	Particulate Matter results in increased expression of KRT18 protein	21491466
D020245	p-Chloromercuribenzoic Acid	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of KRT18 mRNA	26272509
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of KRT18 protein	20732397
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of KRT18 mRNA	23892564
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of KRT18 protein	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of KRT18 mRNA	19162173
D010578	Petroleum	Petroleum affects the expression of KRT18 mRNA	25208076
D010629	Phenformin	Phenformin results in increased expression of KRT18 mRNA	31324951
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of KRT18 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of KRT18 mRNA	19482888
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of KRT18 mRNA	19409407
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of KRT18 protein	19409407
D010634	Phenobarbital	[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of KRT18 protein	20935162
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of KRT18 mRNA	26272509
D010705	Phosgene	Phosgene affects the expression of KRT18 mRNA	16300373
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of KRT18 mRNA	21061450
D010882	Piperonyl Butoxide	[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of KRT18 protein	20101389
C006253	pirinixic acid	pirinixic acid results in decreased expression of KRT18 mRNA	17426115; 18445702;
C006253	pirinixic acid	pirinixic acid results in increased expression of KRT18 mRNA	16221962
D010936	Plant Extracts	Plant Extracts results in increased expression of KRT18 protein modified form	22907900
D010936	Plant Extracts	Plant Extracts results in decreased expression of KRT18 protein	23994094
D010936	Plant Extracts	Plant Extracts results in decreased expression of KRT18 mRNA	28533734
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of KRT18 protein	22144121
C035988	procymidone	procymidone results in increased expression of KRT18 mRNA	15686871
D011374	Progesterone	Progesterone results in decreased expression of KRT18 mRNA	23018184
D011374	Progesterone	Progesterone results in decreased expression of KRT18 mRNA	21795739
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of KRT18 mRNA]	17556502
D011374	Progesterone	Progesterone results in decreased expression of KRT18 mRNA	17556502
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of KRT18 mRNA	25825206
D011441	Propylthiouracil	Propylthiouracil results in increased expression of KRT18 mRNA	24780913
D011748	Pyrogallol	Pyrogallol results in increased expression of KRT18 mRNA	20362636
D011791	Quartz	Quartz results in decreased expression of KRT18 protein	27917503
D011794	Quercetin	Quercetin results in increased expression of KRT18 protein	14750173
D012406	Roxarsone	Roxarsone results in increased expression of KRT18 protein	30005308
C541923	sandostatinLAR	sandostatinLAR results in increased expression of KRT18 mRNA	17210224
D012503	Saponins	Saponins results in decreased expression of KRT18 protein	23994094
C093642	SB 203580	SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of KRT18 protein]	22960429
C015499	schizandrin B	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of KRT18 mRNA]	31150632
D012643	Selenium	Selenium results in increased expression of KRT18 mRNA	19244175
C110991	S-ethyl-N-acetyl-cysteine	S-ethyl-N-acetyl-cysteine inhibits the reaction [sodium arsenite results in increased expression of KRT18 mRNA]	17340120
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of KRT18 protein	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of KRT18 protein	27917503
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of KRT18 mRNA	23221170
D018030	Silver Compounds	Silver Compounds results in decreased expression of KRT18 mRNA	29703973
D012906	Smoke	Smoke results in increased metabolism of KRT18 protein	20015449
C009277	sodium arsenate	sodium arsenate results in increased expression of KRT18 mRNA	23922661
C017947	sodium arsenite	sodium arsenite results in increased expression of KRT18 mRNA	29361514
C017947	sodium arsenite	sodium arsenite affects the expression of KRT18 mRNA	20056578
C017947	sodium arsenite	sodium arsenite affects the expression of KRT18 protein	20056578
C017947	sodium arsenite	sodium arsenite results in increased expression of KRT18 mRNA	19524636
C017947	sodium arsenite	sodium arsenite results in increased expression of KRT18 protein	19524636
C017947	sodium arsenite	S-ethyl-N-acetyl-cysteine inhibits the reaction [sodium arsenite results in increased expression of KRT18 mRNA]	17340120
C017947	sodium arsenite	sodium arsenite affects the expression of KRT18 mRNA	16507464
C017947	sodium arsenite	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of KRT18 mRNA	16368122
C017947	sodium arsenite	sodium arsenite results in decreased expression of KRT18 mRNA	15276417
C017947	sodium arsenite	sodium arsenite results in increased expression of KRT18 mRNA	17340120
C017947	sodium arsenite	sodium arsenite results in increased expression of KRT18 protein	17340120
C016104	sodium bichromate	sodium bichromate results in increased expression of KRT18 mRNA	24612858
C016104	sodium bichromate	sodium bichromate results in increased expression of KRT18 mRNA	25993096
C503854	sodium boranocarbonate	sodium boranocarbonate inhibits the reaction [Ethanol results in increased expression of KRT18 protein modified form]	24946281
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of KRT18 protein	28918527
D053260	Soot	[Soot co-treated with Benzo(a)pyrene] results in decreased expression of KRT18 protein modified form	24464499
D053260	Soot	Soot results in decreased expression of KRT18 protein modified form	24464499
D053260	Soot	Soot results in increased expression of KRT18 mRNA	26551751
C416927	SU 6656	SU 6656 results in increased expression of KRT18 protein	23527294
D000077210	Sunitinib	Sunitinib results in decreased expression of KRT18 mRNA	31533062
D013605	T-2 Toxin	T-2 Toxin results in increased expression of KRT18 mRNA	31299295
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of KRT18 mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of KRT18 mRNA	17884332
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of KRT18 mRNA]	11179685
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of KRT18 mRNA	23152189
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of KRT18 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of KRT18 mRNA	17275934
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of KRT18 mRNA	20959002
D013752	Tetracycline	Tetracycline results in increased expression of KRT18 mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of KRT18 mRNA	16368122
D013853	Thioacetamide	KRT18 protein affects the reaction [Thioacetamide results in increased expression of MMP13 mRNA]	18395095
D013853	Thioacetamide	KRT18 protein affects the reaction [Thioacetamide results in increased expression of MMP2 mRNA]	18395095
D013853	Thioacetamide	KRT18 protein affects the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]	18395095
D013853	Thioacetamide	Thioacetamide results in increased expression of and results in increased phosphorylation of KRT18 protein	18395095
D013853	Thioacetamide	Thioacetamide results in increased expression of KRT18 mRNA	18395095
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of KRT18 mRNA	28943392
D013853	Thioacetamide	Thioacetamide results in increased expression of KRT18 mRNA	23411599
C066185	tingenin B	tingenin B results in increased cleavage of KRT18 protein	27720947
C009495	titanium dioxide	titanium dioxide results in increased phosphorylation of KRT18 protein	21439344
C009495	titanium dioxide	titanium dioxide results in decreased expression of KRT18 mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of KRT18 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of KRT18 protein	30291989
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of KRT18 protein	27189315
D014118	Toxins, Biological	Toxins, Biological affects the expression of KRT18 mRNA	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of KRT18 mRNA	20530235
D014212	Tretinoin	[Tretinoin co-treated with BMP4 protein] results in increased expression of KRT18 protein	30397335
D014212	Tretinoin	Tretinoin results in increased expression of KRT18 mRNA	17034753; 17185354; 21934132; 23724009;
D014212	Tretinoin	Tretinoin results in increased expression of KRT18 protein	17387344
D014212	Tretinoin	[bisphenol F co-treated with Tretinoin] results in decreased expression of KRT18 mRNA	30951980
D014212	Tretinoin	Tretinoin results in increased expression of KRT18 mRNA	16236135; 7201471;
D014212	Tretinoin	Tretinoin results in increased expression of KRT18 protein	7201471
D014212	Tretinoin	Tretinoin results in decreased expression of KRT18 mRNA	24977338
C032910	triadimefon	triadimefon results in decreased expression of KRT18 mRNA	26705709
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
C012589	trichostatin A	trichostatin A results in increased expression of KRT18 mRNA	24935251; 26272509;
D014260	Triclosan	Triclosan results in decreased expression of KRT18 protein	30219713
C052920	trimethylarsine oxide	trimethylarsine oxide results in decreased expression of KRT18 mRNA	17481689
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of KRT18 mRNA	28934090
C080163	trovafloxacin	trovafloxacin results in decreased expression of KRT18 mRNA	24136188
C113580	U 0126	U 0126 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of KRT18 protein]	22960429
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of KRT18 mRNA	15885361
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KRT18 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of KRT18 mRNA	23179753; 23527032; 24383497; 24935251; 26272509; 28001369;
D014635	Valproic Acid	Valproic Acid affects the expression of KRT18 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in increased expression of KRT18 mRNA	15345369
D014640	Vancomycin	Vancomycin results in decreased expression of KRT18 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of KRT18 mRNA	23940539
C025643	vinclozolin	vinclozolin affects the expression of KRT18 mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of KRT18 mRNA	15686871
D000077235	Vinorelbine	Vinorelbine results in increased expression of KRT18 protein	16685278
D000077235	Vinorelbine	Vinorelbine results in increased metabolism of KRT18 protein	16685278
D014800	Vitallium	Vitallium analog results in decreased expression of KRT18 mRNA	23825117
D014801	Vitamin A	Vitamin A results in increased expression of KRT18 mRNA	17034753
D000077337	Vorinostat	[Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased cleavage of KRT18 protein	15754201
D014859	Warfarin	Warfarin results in decreased expression of KRT18 mRNA	20493250
D014874	Water Pollutants, Chemical	Water Pollutants, Chemical affects the expression of KRT18 mRNA	25208076

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0007	Acetylation
KW-0131	Cell cycle
KW-0175	Coiled coil
KW-0963	Cytoplasm
KW-0903	Direct protein sequencing
KW-0225	Disease mutation
KW-0325	Glycoprotein
KW-0945	Host-virus interaction
KW-0403	Intermediate filament
KW-1017	Isopeptide bond
KW-0416	Keratin
KW-0488	Methylation
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0832	Ubl conjugation

Interpro

InterPro ID	InterPro Term
IPR018039	IF_conserved
IPR039008	IF_rod_dom
IPR042180	IF_rod_dom_coil1B
IPR027695	Keratin-18
IPR002957	Keratin_I

PROSITE

PROSITE ID	PROSITE Term
PS00226	IF_ROD_1
PS51842	IF_ROD_2

Pfam

Pfam ID	Pfam Term
PF00038	Filament

Gene: KRT18

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Identified variants/mutations related to cleft phenotype

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction