| Tag | Content |
|---|---|
| Uniprot ID | P05783; Q53G38; Q5U0N8; Q9BW26; |
| Entrez ID | 3875 |
| Genbank protein ID | AAH04253.1; AAX07828.1; CAA31377.1; AAH72017.1; CAA31369.1; CAA31375.1; AAH08636.1; AAH20982.1; AAH00698.1; AAH00180.1; AAV38219.1; AAA59461.1; BAD96813.1; |
| Genbank nucleotide ID | NM_000224.2; NM_199187.1; |
| Ensembl protein ID | ENSP00000373487; ENSP00000373489; |
| Ensembl nucleotide ID | ENSG00000111057 |
| Gene name | Keratin, type I cytoskeletal 18 |
| Gene symbol | KRT18 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 28232668 |
| Functional description | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
| Sequence | MSFTTRSTFS TNYRSLGSVQ APSYGARPVS SAASVYAGAG GSGSRISVSR STSFRGGMGS 60 GGLATGIAGG LAGMGGIQNE KETMQSLNDR LASYLDRVRS LETENRRLES KIREHLEKKG 120 PQVRDWSHYF KIIEDLRAQI FANTVDNARI VLQIDNARLA ADDFRVKYET ELAMRQSVEN 180 DIHGLRKVID DTNITRLQLE TEIEALKEEL LFMKKNHEEE VKGLQAQIAS SGLTVEVDAP 240 KSQDLAKIMA DIRAQYDELA RKNREELDKY WSQQIEESTT VVTTQSAEVG AAETTLTELR 300 RTVQSLEIDL DSMRNLKASL ENSLREVEAR YALQMEQLNG ILLHLESELA QTRAEGQRQA 360 QEYEALLNIK VKLEAEIATY RRLLEDGEDF NLGDALDSSN SMQTIQKTTT RRIVDGKVVS 420 ETNDTKVLRH |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.