| Tag | Content |
|---|---|
| Uniprot ID | P07477; A1A509; A6NJ71; B2R5I5; Q5NV57; Q7M4N3; Q7M4N4; Q92955; Q9HAN4; Q9HAN5; Q9HAN6; Q9HAN7; |
| Entrez ID | 5644 |
| Genbank protein ID | EAL23773.1; AAA61231.1; AAG30943.1; AAG30948.1; AAI28227.1; AAC50728.1; AAG30947.1; AAC80207.1; EAW51925.1; AAG30949.1; BAG35132.1; |
| Genbank nucleotide ID | NM_002769.4 |
| Ensembl protein ID | ENSP00000308720; ENSP00000479217; |
| Ensembl nucleotide ID | ENSG00000204983; ENSG00000274247; |
| Gene name | Trypsin-1 |
| Gene symbol | PRSS1 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 26449438 |
| Functional description | Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. |
| Sequence | MNPLLILTFV AAALAAPFDD DDKIVGGYNC EENSVPYQVS LNSGYHFCGG SLINEQWVVS 60 AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPQYD RKTLNNDIML IKLSSRAVIN 120 ARVSTISLPT APPATGTKCL ISGWGNTASS GADYPDELQC LDAPVLSQAK CEASYPGKIT 180 SNMFCVGFLE GGKDSCQGDS GGPVVCNGQL QGVVSWGDGC AQKNKPGVYT KVYNYVKWIK 240 NTIAANS 247 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.