CleftGeneDB-Search

Gene: MMP3

Basic information

Tag	Content
Uniprot ID	P08254; B2R8B8; Q3B7S0; Q6GRF8;
Entrez ID	4314
Genbank protein ID	AAI07492.1; AAA36321.1; CAA28859.1; AAI05955.1; AAI07491.1; BAD97011.1; AAB36942.1; AAH69716.1; AAK95247.1; AAH74815.1; BAD97003.1; AAH69676.1; AAH74869.1; BAG36115.1; EAW67032.1;
Genbank nucleotide ID	NM_002422.4
Ensembl protein ID	ENSP00000299855
Ensembl nucleotide ID	ENSG00000149968
Gene name	Stromelysin-1
Gene symbol	MMP3
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type	CPO,CL/P
Developmental stage
Data sources	Manually collected
Reference	17537400
Functional description	Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Sequence	MKSLPILLLL CVAVCSAYPL DGAARGEDTS MNLVQKYLEN YYDLKKDVKQ FVRRKDSGPV 60 VKKIREMQKF LGLEVTGKLD SDTLEVMRKP RCGVPDVGHF RTFPGIPKWR KTHLTYRIVN 120 YTPDLPKDAV DSAVEKALKV WEEVTPLTFS RLYEGEADIM ISFAVREHGD FYPFDGPGNV 180 LAHAYAPGPG INGDAHFDDD EQWTKDTTGT NLFLVAAHEI GHSLGLFHSA NTEALMYPLY 240 HSLTDLTRFR LSQDDINGIQ SLYGPPPDSP ETPLVPTEPV PPEPGTPANC DPALSFDAVS 300 TLRGEILIFK DRHFWRKSLR KLEPELHLIS SFWPSLPSGV DAAYEVTSKD LVFIFKGNQF 360 WAIRGNEVRA GYPRGIHTLG FPPTVRKIDA AISDKEKNKT YFFVEDKYWR FDEKRNSMEP 420 GFPKQIAEDF PGIDSKIDAV FEEFGFFYFF TGSSQLEFDP NAKKVTHTLK SNSWLNC 477

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1B3D
1B8Y
1BIW
1BM6
1BQO
1C3I
1C8T
1CAQ
1CIZ
1CQR
1D5J
1D7X
1D8F
1D8M
1G05
1G49
1G4K
1HFS
1HY7
1M1W
1OO9
1QIA
1QIC
1SLM
1SLN
1UEA
1UMS
1UMT
1USN
2D1O
2JNP
2JT5
2JT6
2SRT
2USN
3OHL
3OHO
3USN
4DPE
4G9L
4JA1
6MAV
6N9D
1CAQ
1CIZ
1HY7
1SLM
1UEA
1USN
2SRT

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	MMP3	403445	Q6Y4Q5			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	MMP3	102170893	A0A452FPV6			Capra hircus	Prediction	More>>
1:1 ortholog	MMP3	100034195	Q28397			Equus caballus	Prediction	More>>
1:1 ortholog	MMP3	4314	P08254	CPO,CL/P		Homo sapiens	Publication	More>>
1:1 ortholog	Mmp3	17392	Q922W6		E12.5, E13.5, E14.5	Mus musculus	Prediction	More>>
1:1 ortholog	MMP3	451511	H2Q4N2			Pan troglodytes	Prediction	More>>
1:1 ortholog	MMP3		F1SV58			Sus scrofa	Prediction	More>>
1:1 ortholog	Mmp3		F1LPL9			Rattus norvegicus	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
MMP3	rs3025058; -1171 5A>6A	Sequencing; SSCP; PCR-RFLP	29738289
MMP3	-1171-5A allele	PCR	17537400

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs1555005966	p.Ser3Gly	missense variant	-	NC_000011.10:g.102843540T>C	gnomAD
rs782579657	p.Leu4Arg	missense variant	-	NC_000011.10:g.102843536A>C	ExAC,gnomAD
rs1453377591	p.Ile6Thr	missense variant	-	NC_000011.10:g.102843530A>G	TOPMed,gnomAD
rs1414816680	p.Leu8Pro	missense variant	-	NC_000011.10:g.102843524A>G	TOPMed,gnomAD
rs781850826	p.Leu9Trp	missense variant	-	NC_000011.10:g.102843521A>C	ExAC,gnomAD
rs374032529	p.Leu10Pro	missense variant	-	NC_000011.10:g.102843518A>G	ESP,ExAC,gnomAD
rs113324830	p.Cys11Trp	missense variant	-	NC_000011.10:g.102843514G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs113324830	p.Cys11Ter	stop gained	-	NC_000011.10:g.102843514G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs201131528	p.Val12Met	missense variant	-	NC_000011.10:g.102843513C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1437252982	p.Ala13Thr	missense variant	-	NC_000011.10:g.102843510C>T	TOPMed
rs555385493	p.Ala13Val	missense variant	-	NC_000011.10:g.102843509G>A	1000Genomes,ExAC
rs782155762	p.Cys15Gly	missense variant	-	NC_000011.10:g.102843504A>C	ExAC,gnomAD
rs370303354	p.Ala17Val	missense variant	-	NC_000011.10:g.102843497G>A	ESP,ExAC,TOPMed,gnomAD
rs1440362748	p.Gly22Glu	missense variant	-	NC_000011.10:g.102843482C>T	TOPMed,gnomAD
rs1555005946	p.Ala23Gly	missense variant	-	NC_000011.10:g.102843479G>C	gnomAD
rs142481975	p.Ala23Thr	missense variant	-	NC_000011.10:g.102843480C>T	ESP,ExAC,gnomAD
rs1555005944	p.Ala24Glu	missense variant	-	NC_000011.10:g.102843476G>T	gnomAD
rs1370088939	p.Arg25Ser	missense variant	-	NC_000011.10:g.102843472C>A	TOPMed
rs572386210	p.Asp28His	missense variant	-	NC_000011.10:g.102843465C>G	ExAC,TOPMed,gnomAD
rs572386210	p.Asp28Asn	missense variant	-	NC_000011.10:g.102843465C>T	ExAC,TOPMed,gnomAD
COSM1321949	p.Asp28Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102843464T>C	NCI-TCGA Cosmic
rs782405107	p.Thr29Ile	missense variant	-	NC_000011.10:g.102843461G>A	ExAC,gnomAD
rs137912924	p.Thr29Ala	missense variant	-	NC_000011.10:g.102843462T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs137912924	p.Thr29Ser	missense variant	-	NC_000011.10:g.102843462T>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1211155799	p.Ser30Asn	missense variant	-	NC_000011.10:g.102843458C>T	TOPMed
COSM3868294	p.Met31Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102843454C>T	NCI-TCGA Cosmic
rs782196428	p.Leu33Pro	missense variant	-	NC_000011.10:g.102843449A>G	ExAC
COSM4017291	p.Leu33Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102843450G>A	NCI-TCGA Cosmic
rs1555005931	p.Val34Ile	missense variant	-	NC_000011.10:g.102843447C>T	gnomAD
NCI-TCGA novel	p.Gln35His	missense variant	-	NC_000011.10:g.102843442C>A	NCI-TCGA
rs782569082	p.Gln35Pro	missense variant	-	NC_000011.10:g.102843443T>G	ExAC,gnomAD
rs1555005930	p.Gln35Ter	stop gained	-	NC_000011.10:g.102843444G>A	gnomAD
rs782254329	p.Lys36Glu	missense variant	-	NC_000011.10:g.102842916T>C	ExAC,gnomAD
rs576127996	p.Tyr37His	missense variant	-	NC_000011.10:g.102842913A>G	1000Genomes,ExAC,gnomAD
rs1555005838	p.Tyr37Cys	missense variant	-	NC_000011.10:g.102842912T>C	gnomAD
rs1555005837	p.Leu38Pro	missense variant	-	NC_000011.10:g.102842909A>G	gnomAD
rs782190144	p.Glu39Asp	missense variant	-	NC_000011.10:g.102842905T>G	ExAC,gnomAD
rs782553958	p.Tyr42His	missense variant	-	NC_000011.10:g.102842898A>G	ExAC,TOPMed,gnomAD
rs138533783	p.Tyr42Ter	stop gained	-	NC_000011.10:g.102842896G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs782778748	p.Asp43Asn	missense variant	-	NC_000011.10:g.102842895C>T	ExAC,TOPMed,gnomAD
RCV000454524	p.Lys45Glu	missense variant	-	NC_000011.10:g.102842889T>C	ClinVar
rs782730515	p.Lys45Arg	missense variant	-	NC_000011.10:g.102842888T>C	ExAC,TOPMed,gnomAD
rs679620	p.Lys45Glu	missense variant	-	NC_000011.10:g.102842889T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1388178949	p.Asp47Tyr	missense variant	-	NC_000011.10:g.102842883C>A	TOPMed
rs370164016	p.Gln50Pro	missense variant	-	NC_000011.10:g.102842873T>G	ESP,ExAC,TOPMed,gnomAD
rs372498396	p.Gln50Lys	missense variant	-	NC_000011.10:g.102842874G>T	ESP,TOPMed,gnomAD
rs778863363	p.Phe51Cys	missense variant	-	NC_000011.10:g.102842870A>C	ExAC,gnomAD
rs148285569	p.Arg53Lys	missense variant	-	NC_000011.10:g.102842864C>T	ESP,ExAC,TOPMed,gnomAD
rs782425284	p.Arg54Lys	missense variant	-	NC_000011.10:g.102842861C>T	ExAC,TOPMed,gnomAD
rs1555005822	p.Asp56Glu	missense variant	-	NC_000011.10:g.102842854G>C	gnomAD
rs1555005824	p.Asp56Asn	missense variant	-	NC_000011.10:g.102842856C>T	gnomAD
rs782654888	p.Gly58Ser	missense variant	-	NC_000011.10:g.102842850C>T	gnomAD
rs1487605173	p.Pro59Leu	missense variant	-	NC_000011.10:g.102842846G>A	TOPMed,gnomAD
rs1555005817	p.Val60Ala	missense variant	-	NC_000011.10:g.102842843A>G	gnomAD
rs554448579	p.Val61Phe	missense variant	-	NC_000011.10:g.102842841C>A	1000Genomes,ExAC,gnomAD
rs1555005816	p.Val61Asp	missense variant	-	NC_000011.10:g.102842840A>T	gnomAD
rs781930148	p.Ile64Val	missense variant	-	NC_000011.10:g.102842832T>C	ExAC,gnomAD
COSM1237692	p.Ile64SerPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000011.10:g.102842832T>-	NCI-TCGA Cosmic
rs143174783	p.Arg65Ter	stop gained	-	NC_000011.10:g.102842829G>A	ESP,ExAC,TOPMed,gnomAD
rs202121594	p.Arg65Leu	missense variant	-	NC_000011.10:g.102842828C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs202121594	p.Arg65Gln	missense variant	-	NC_000011.10:g.102842828C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1473230952	p.Gln68His	missense variant	-	NC_000011.10:g.102842818C>A	TOPMed
rs782511984	p.Lys69Thr	missense variant	-	NC_000011.10:g.102842816T>G	ExAC,gnomAD
rs782511984	p.Lys69Met	missense variant	-	NC_000011.10:g.102842816T>A	ExAC,gnomAD
rs1555005800	p.Glu74Asp	missense variant	-	NC_000011.10:g.102842800C>G	gnomAD
rs201018157	p.Glu74Ala	missense variant	-	NC_000011.10:g.102842801T>G	1000Genomes
rs554987933	p.Thr76Lys	missense variant	-	NC_000011.10:g.102842795G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs554987933	p.Thr76Met	missense variant	-	NC_000011.10:g.102842795G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs568922671	p.Gly77Val	missense variant	-	NC_000011.10:g.102842792C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs782614229	p.Ser81Ala	missense variant	-	NC_000011.10:g.102842781A>C	ExAC,gnomAD
rs552104362	p.Asp82Asn	missense variant	-	NC_000011.10:g.102842778C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1351010097	p.Thr83Ala	missense variant	-	NC_000011.10:g.102842775T>C	TOPMed,gnomAD
rs782173998	p.Leu84Pro	missense variant	-	NC_000011.10:g.102842771A>G	ExAC,TOPMed,gnomAD
rs1312012736	p.Leu84Val	missense variant	-	NC_000011.10:g.102842772G>C	TOPMed,gnomAD
rs1555005785	p.Val86Leu	missense variant	-	NC_000011.10:g.102842766C>A	gnomAD
rs1555005785	p.Val86Met	missense variant	-	NC_000011.10:g.102842766C>T	gnomAD
rs1555005783	p.Met87Thr	missense variant	-	NC_000011.10:g.102842762A>G	gnomAD
rs782531877	p.Arg88His	missense variant	-	NC_000011.10:g.102842759C>T	ExAC,TOPMed,gnomAD
rs377547395	p.Arg88Cys	missense variant	-	NC_000011.10:g.102842760G>A	ESP,ExAC,TOPMed,gnomAD
rs782531877	p.Arg88Leu	missense variant	-	NC_000011.10:g.102842759C>A	ExAC,TOPMed,gnomAD
rs377547395	p.Arg88Ser	missense variant	-	NC_000011.10:g.102842760G>T	ESP,ExAC,TOPMed,gnomAD
rs1482872804	p.Lys89Arg	missense variant	-	NC_000011.10:g.102842756T>C	TOPMed
NCI-TCGA novel	p.Pro90Leu	missense variant	-	NC_000011.10:g.102842753G>A	NCI-TCGA
COSM6066994	p.Pro90Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102842754G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Arg91GlyPheSerTerUnkUnk	frameshift	-	NC_000011.10:g.102842752G>-	NCI-TCGA
rs922877596	p.Arg91Ser	missense variant	-	NC_000011.10:g.102842749C>A	TOPMed,gnomAD
rs141650167	p.Arg91Trp	missense variant	-	NC_000011.10:g.102842751T>A	ESP,TOPMed
rs1555005777	p.Cys92Tyr	missense variant	-	NC_000011.10:g.102842747C>T	gnomAD
COSM1350415	p.Cys92Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102842748A>G	NCI-TCGA Cosmic
rs782127556	p.Pro95Thr	missense variant	-	NC_000011.10:g.102842739G>T	ExAC,gnomAD
rs782127556	p.Pro95Ser	missense variant	-	NC_000011.10:g.102842739G>A	ExAC,gnomAD
rs602128	p.Asp96Glu	missense variant	-	NC_000011.10:g.102842734A>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs547601378	p.Val97Phe	missense variant	-	NC_000011.10:g.102842733C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs782571621	p.Val97Ala	missense variant	-	NC_000011.10:g.102842732A>G	ExAC,TOPMed,gnomAD
rs547601378	p.Val97Ile	missense variant	-	NC_000011.10:g.102842733C>T	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe100Leu	missense variant	-	NC_000011.10:g.102842724A>G	NCI-TCGA
NCI-TCGA novel	p.Phe100Val	missense variant	-	NC_000011.10:g.102842724A>C	NCI-TCGA
rs1555005770	p.Thr102Ala	missense variant	-	NC_000011.10:g.102842718T>C	gnomAD
rs989461395	p.Phe103Cys	missense variant	-	NC_000011.10:g.102842714A>C	TOPMed,gnomAD
rs1555005764	p.Phe103Leu	missense variant	-	NC_000011.10:g.102842715A>G	gnomAD
rs782503307	p.Pro104Leu	missense variant	-	NC_000011.10:g.102842711G>A	ExAC,gnomAD
rs781910577	p.Gly105Arg	missense variant	-	NC_000011.10:g.102842709C>G	ExAC,gnomAD
rs1555005757	p.Gly105Asp	missense variant	-	NC_000011.10:g.102842708C>T	gnomAD
rs1300996167	p.Ile106Met	missense variant	-	NC_000011.10:g.102842704G>C	TOPMed
rs151123532	p.Pro107Leu	missense variant	-	NC_000011.10:g.102842702G>A	ESP,ExAC,TOPMed,gnomAD
rs61753776	p.Trp109Arg	missense variant	-	NC_000011.10:g.102842697A>T	TOPMed,gnomAD
rs61753776	p.Trp109Gly	missense variant	-	NC_000011.10:g.102842697A>C	TOPMed,gnomAD
COSM3442735	p.Trp109Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000011.10:g.102842696C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Thr112Ala	missense variant	-	NC_000011.10:g.102842688T>C	NCI-TCGA
rs1555005747	p.His113Tyr	missense variant	-	NC_000011.10:g.102842685G>A	gnomAD
rs561892904	p.Leu114Arg	missense variant	-	NC_000011.10:g.102842681A>C	1000Genomes,ExAC,gnomAD
rs1341658484	p.Leu114Phe	missense variant	-	NC_000011.10:g.102842682G>A	TOPMed
rs561892904	p.Leu114Pro	missense variant	-	NC_000011.10:g.102842681A>G	1000Genomes,ExAC,gnomAD
rs782775445	p.Tyr116Ter	stop gained	-	NC_000011.10:g.102842674G>T	ExAC,TOPMed,gnomAD
rs782775445	p.Tyr116Ter	stop gained	-	NC_000011.10:g.102842674G>C	ExAC,TOPMed,gnomAD
rs142984123	p.Tyr116Cys	missense variant	-	NC_000011.10:g.102842675T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs782160486	p.Arg117Lys	missense variant	-	NC_000011.10:g.102842672C>T	ExAC,gnomAD
rs577046877	p.Ile118Thr	missense variant	-	NC_000011.10:g.102842577A>G	1000Genomes,ExAC,gnomAD
rs782782597	p.Val119Leu	missense variant	-	NC_000011.10:g.102842575C>A	ExAC,gnomAD
rs1555005716	p.Asn120Thr	missense variant	-	NC_000011.10:g.102842571T>G	gnomAD
rs1360800439	p.Tyr121Cys	missense variant	-	NC_000011.10:g.102842568T>C	TOPMed
rs1364558361	p.Pro123Thr	missense variant	-	NC_000011.10:g.102842563G>T	TOPMed,gnomAD
rs1364558361	p.Pro123Ser	missense variant	-	NC_000011.10:g.102842563G>A	TOPMed,gnomAD
rs1433100016	p.Leu125Phe	missense variant	-	NC_000011.10:g.102842555C>G	TOPMed
rs782730037	p.Pro126Thr	missense variant	-	NC_000011.10:g.102842554G>T	ExAC,gnomAD
rs1555005709	p.Lys127Asn	missense variant	-	NC_000011.10:g.102842549T>G	gnomAD
rs782138485	p.Lys127Glu	missense variant	-	NC_000011.10:g.102842551T>C	ExAC,TOPMed,gnomAD
rs781991534	p.Asp128Gly	missense variant	-	NC_000011.10:g.102842547T>C	ExAC
COSM3442733	p.Asp128Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102842548C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ala129Thr	missense variant	-	NC_000011.10:g.102842545C>T	NCI-TCGA
NCI-TCGA novel	p.Ala129Val	missense variant	-	NC_000011.10:g.102842544G>A	NCI-TCGA
NCI-TCGA novel	p.Asp131Gly	missense variant	-	NC_000011.10:g.102842538T>C	NCI-TCGA
NCI-TCGA novel	p.Ala133Val	missense variant	-	NC_000011.10:g.102842532G>A	NCI-TCGA
NCI-TCGA novel	p.Val134Asp	missense variant	-	NC_000011.10:g.102842529A>T	NCI-TCGA
rs782312096	p.Val134Leu	missense variant	-	NC_000011.10:g.102842530C>G	ExAC,TOPMed,gnomAD
rs782312096	p.Val134Ile	missense variant	-	NC_000011.10:g.102842530C>T	ExAC,TOPMed,gnomAD
rs781941674	p.Ala137Val	missense variant	-	NC_000011.10:g.102842520G>A	ExAC,gnomAD
rs782220811	p.Ala137Pro	missense variant	-	NC_000011.10:g.102842521C>G	ExAC,TOPMed,gnomAD
rs782220811	p.Ala137Thr	missense variant	-	NC_000011.10:g.102842521C>T	ExAC,TOPMed,gnomAD
COSM922297	p.Lys139Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102842515T>C	NCI-TCGA Cosmic
COSM922296	p.Val140Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102842511A>C	NCI-TCGA Cosmic
rs1314407176	p.Trp141Ter	stop gained	-	NC_000011.10:g.102842507C>T	TOPMed
rs782241431	p.Glu142Val	missense variant	-	NC_000011.10:g.102842505T>A	ExAC,gnomAD
rs782386185	p.Glu142Lys	missense variant	-	NC_000011.10:g.102842506C>T	ExAC,gnomAD
rs1266873022	p.Glu143Ala	missense variant	-	NC_000011.10:g.102842502T>G	TOPMed,gnomAD
rs1555005695	p.Glu143Lys	missense variant	-	NC_000011.10:g.102842503C>T	gnomAD
rs782542331	p.Val144Ala	missense variant	-	NC_000011.10:g.102842499A>G	ExAC,gnomAD
rs373783506	p.Val144Met	missense variant	-	NC_000011.10:g.102842500C>T	ESP,ExAC,gnomAD
rs1555005691	p.Leu147Pro	missense variant	-	NC_000011.10:g.102842490A>G	gnomAD
rs1555005688	p.Phe149Leu	missense variant	-	NC_000011.10:g.102842483G>T	gnomAD
rs782465369	p.Arg151Ser	missense variant	-	NC_000011.10:g.102842477C>G	ExAC,TOPMed,gnomAD
rs782555708	p.Tyr153Phe	missense variant	-	NC_000011.10:g.102842472T>A	ExAC,TOPMed,gnomAD
rs148579119	p.Tyr153His	missense variant	-	NC_000011.10:g.102842473A>G	ESP,ExAC,TOPMed,gnomAD
rs782555708	p.Tyr153Cys	missense variant	-	NC_000011.10:g.102842472T>C	ExAC,TOPMed,gnomAD
rs1555005682	p.Glu154Lys	missense variant	-	NC_000011.10:g.102842470C>T	gnomAD
rs781892488	p.Gly155Glu	missense variant	-	NC_000011.10:g.102842466C>T	ExAC,gnomAD
rs1555005679	p.Glu156Lys	missense variant	-	NC_000011.10:g.102842464C>T	gnomAD
rs1555005678	p.Glu156Gly	missense variant	-	NC_000011.10:g.102842463T>C	gnomAD
rs145941285	p.Ile159Thr	missense variant	-	NC_000011.10:g.102842454A>G	ESP,ExAC,TOPMed,gnomAD
rs1555005676	p.Ile159Val	missense variant	-	NC_000011.10:g.102842455T>C	gnomAD
rs781978075	p.Met160Thr	missense variant	-	NC_000011.10:g.102842451A>G	ExAC,gnomAD
rs113453592	p.Met160Val	missense variant	-	NC_000011.10:g.102842452T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs113453592	p.Met160Leu	missense variant	-	NC_000011.10:g.102842452T>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs139243180	p.Met160Ile	missense variant	-	NC_000011.10:g.102842450C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1555005669	p.Ile161Thr	missense variant	-	NC_000011.10:g.102842448A>G	gnomAD
rs1555005667	p.Ser162Pro	missense variant	-	NC_000011.10:g.102842446A>G	gnomAD
NCI-TCGA novel	p.Ala164Val	missense variant	-	NC_000011.10:g.102842439G>A	NCI-TCGA
rs1555005664	p.Ala164Glu	missense variant	-	NC_000011.10:g.102842439G>T	gnomAD
rs146212400	p.Val165Ala	missense variant	-	NC_000011.10:g.102842436A>G	ESP,ExAC,TOPMed,gnomAD
rs1345987969	p.Val165Ile	missense variant	-	NC_000011.10:g.102842437C>T	TOPMed
rs1555005660	p.Arg166Lys	missense variant	-	NC_000011.10:g.102842433C>T	gnomAD
rs1555005660	p.Arg166Ile	missense variant	-	NC_000011.10:g.102842433C>A	gnomAD
rs781934300	p.Glu167Lys	missense variant	-	NC_000011.10:g.102842431C>T	ExAC
NCI-TCGA novel	p.Asp170Ala	missense variant	-	NC_000011.10:g.102842270T>G	NCI-TCGA
rs782223398	p.Phe171Leu	missense variant	-	NC_000011.10:g.102842268A>G	ExAC,gnomAD
rs368913824	p.Tyr172Ter	stop gained	-	NC_000011.10:g.102842263G>T	ESP,ExAC,gnomAD
rs1555005577	p.Tyr172His	missense variant	-	NC_000011.10:g.102842265A>G	gnomAD
rs368913824	p.Tyr172Ter	stop gained	-	NC_000011.10:g.102842263G>C	ESP,ExAC,gnomAD
rs781897818	p.Pro173Leu	missense variant	-	NC_000011.10:g.102842261G>A	ExAC,gnomAD
rs1555005576	p.Pro173Thr	missense variant	-	NC_000011.10:g.102842262G>T	gnomAD
rs781897818	p.Pro173Arg	missense variant	-	NC_000011.10:g.102842261G>C	ExAC,gnomAD
rs1555005576	p.Pro173Ala	missense variant	-	NC_000011.10:g.102842262G>C	gnomAD
rs782669256	p.Phe174Ser	missense variant	-	NC_000011.10:g.102842258A>G	ExAC,TOPMed,gnomAD
rs1555005573	p.Phe174Leu	missense variant	-	NC_000011.10:g.102842259A>G	gnomAD
NCI-TCGA novel	p.Gly178Val	missense variant	-	NC_000011.10:g.102842246C>A	NCI-TCGA
rs782745338	p.Gly178Arg	missense variant	-	NC_000011.10:g.102842247C>T	ExAC,gnomAD
rs782500546	p.Leu181Ter	stop gained	-	NC_000011.10:g.102842237A>T	ExAC,TOPMed,gnomAD
rs1283847664	p.Ala182Asp	missense variant	-	NC_000011.10:g.102842234G>T	TOPMed
rs1227842713	p.His183Arg	missense variant	-	NC_000011.10:g.102842231T>C	TOPMed,gnomAD
rs782147410	p.Ala184Asp	missense variant	-	NC_000011.10:g.102842228G>T	ExAC,gnomAD
rs782806413	p.Ala184Ser	missense variant	-	NC_000011.10:g.102842229C>A	ExAC,TOPMed,gnomAD
rs376760953	p.Ala186Asp	missense variant	-	NC_000011.10:g.102842222G>T	ESP,ExAC,TOPMed,gnomAD
rs376760953	p.Ala186Val	missense variant	-	NC_000011.10:g.102842222G>A	ESP,ExAC,TOPMed,gnomAD
rs140794544	p.Pro187Ser	missense variant	-	NC_000011.10:g.102842220G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro187Leu	missense variant	-	NC_000011.10:g.102842219G>A	NCI-TCGA
rs1555005557	p.Gly188Glu	missense variant	-	NC_000011.10:g.102842216C>T	gnomAD
rs782108213	p.Gly188Arg	missense variant	-	NC_000011.10:g.102842217C>T	ExAC,gnomAD
COSM3808191	p.Gly188Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102842216C>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Pro189Ser	missense variant	-	NC_000011.10:g.102842214G>A	NCI-TCGA
rs1555005554	p.Pro189Leu	missense variant	-	NC_000011.10:g.102842213G>A	gnomAD
rs782385032	p.Gly190Glu	missense variant	-	NC_000011.10:g.102842210C>T	ExAC,gnomAD
COSM1492416	p.Gly190Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102842210C>A	NCI-TCGA Cosmic
rs1450225675	p.Asn192Asp	missense variant	-	NC_000011.10:g.102842205T>C	TOPMed,gnomAD
rs1450225675	p.Asn192Tyr	missense variant	-	NC_000011.10:g.102842205T>A	TOPMed,gnomAD
rs782028810	p.Ala195Asp	missense variant	-	NC_000011.10:g.102842195G>T	ExAC,gnomAD
rs782241657	p.Ala195Ser	missense variant	-	NC_000011.10:g.102842196C>A	ExAC,TOPMed,gnomAD
rs782190532	p.Asp198Glu	missense variant	-	NC_000011.10:g.102842185A>T	ExAC,gnomAD
rs782557530	p.Asp199Val	missense variant	-	NC_000011.10:g.102842183T>A	ExAC,gnomAD
rs1156265503	p.Asp200Glu	missense variant	-	NC_000011.10:g.102842179A>C	TOPMed
rs782487068	p.Glu201Gln	missense variant	-	NC_000011.10:g.102842178C>G	ExAC,gnomAD
rs782487068	p.Glu201Lys	missense variant	-	NC_000011.10:g.102842178C>T	ExAC,gnomAD
COSM428294	p.Gln202Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102842175G>T	NCI-TCGA Cosmic
rs1453941959	p.Lys205Asn	missense variant	-	NC_000011.10:g.102842164C>A	TOPMed,gnomAD
rs1309603660	p.Gly209Ala	missense variant	-	NC_000011.10:g.102840593C>G	TOPMed,gnomAD
rs1309603660	p.Gly209Glu	missense variant	-	NC_000011.10:g.102840593C>T	TOPMed,gnomAD
rs1358457873	p.Thr210Ser	missense variant	-	NC_000011.10:g.102840591T>A	TOPMed,gnomAD
rs1358457873	p.Thr210Pro	missense variant	-	NC_000011.10:g.102840591T>G	TOPMed,gnomAD
NCI-TCGA novel	p.Phe213Leu	missense variant	-	NC_000011.10:g.102840580A>C	NCI-TCGA
rs1220025147	p.Leu214Ile	missense variant	-	NC_000011.10:g.102840579G>T	TOPMed,gnomAD
rs782754459	p.Val215Ile	missense variant	-	NC_000011.10:g.102840576C>T	ExAC,TOPMed,gnomAD
rs782754459	p.Val215Leu	missense variant	-	NC_000011.10:g.102840576C>G	ExAC,TOPMed,gnomAD
rs782547430	p.Ala217Thr	missense variant	-	NC_000011.10:g.102840570C>T	ExAC,gnomAD
rs557512280	p.His218Gln	missense variant	-	NC_000011.10:g.102840565A>C	1000Genomes,ExAC,TOPMed,gnomAD
COSM3868290	p.His218Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102840567G>A	NCI-TCGA Cosmic
rs782711373	p.Glu219Asp	missense variant	-	NC_000011.10:g.102840562T>G	ExAC,TOPMed,gnomAD
rs150552863	p.Ile220Thr	missense variant	-	NC_000011.10:g.102840560A>G	ESP,ExAC,TOPMed,gnomAD
rs782720970	p.Gly221Ala	missense variant	-	NC_000011.10:g.102840557C>G	ExAC,gnomAD
rs1555005290	p.His222Arg	missense variant	-	NC_000011.10:g.102840554T>C	gnomAD
COSM4017288	p.Gly225Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102840546C>A	NCI-TCGA Cosmic
rs1393459835	p.Ala230Pro	missense variant	-	NC_000011.10:g.102840531C>G	TOPMed
rs782071125	p.Leu235Phe	missense variant	-	NC_000011.10:g.102840514C>G	ExAC,TOPMed
rs781926097	p.Met236Val	missense variant	-	NC_000011.10:g.102840513T>C	ExAC,gnomAD
rs782364467	p.Met236Arg	missense variant	-	NC_000011.10:g.102840512A>C	ExAC,gnomAD
rs782213288	p.Tyr237Ter	stop gained	-	NC_000011.10:g.102840508G>T	ExAC,TOPMed,gnomAD
rs782665147	p.Pro238Ser	missense variant	-	NC_000011.10:g.102840507G>A	ExAC,gnomAD
rs537509437	p.Leu239Pro	missense variant	-	NC_000011.10:g.102840503A>G	1000Genomes,ExAC,gnomAD
rs1555005283	p.Tyr240Phe	missense variant	-	NC_000011.10:g.102840500T>A	gnomAD
rs1352244221	p.His241Tyr	missense variant	-	NC_000011.10:g.102840498G>A	TOPMed
rs1443827949	p.Leu243Phe	missense variant	-	NC_000011.10:g.102840492G>A	TOPMed
rs1381652352	p.Thr244Ile	missense variant	-	NC_000011.10:g.102840488G>A	TOPMed
rs767046399	p.Thr244Ala	missense variant	-	NC_000011.10:g.102840489T>C	ExAC,gnomAD
rs782553242	p.Asp245Ala	missense variant	-	NC_000011.10:g.102840485T>G	TOPMed,gnomAD
rs781869389	p.Arg248Leu	missense variant	-	NC_000011.10:g.102840476C>A	ExAC,TOPMed,gnomAD
rs41357345	p.Arg248Gly	missense variant	-	NC_000011.10:g.102840477G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs781869389	p.Arg248Gln	missense variant	-	NC_000011.10:g.102840476C>T	ExAC,TOPMed,gnomAD
rs41357345	p.Arg248Trp	missense variant	-	NC_000011.10:g.102840477G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs782146175	p.Arg250Cys	missense variant	-	NC_000011.10:g.102840471G>A	ExAC,TOPMed,gnomAD
rs148047905	p.Arg250Leu	missense variant	-	NC_000011.10:g.102840470C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs148047905	p.Arg250His	missense variant	-	NC_000011.10:g.102840470C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1200652061	p.Leu251Gln	missense variant	-	NC_000011.10:g.102840467A>T	TOPMed
rs782392767	p.Gln253Arg	missense variant	-	NC_000011.10:g.102840461T>C	ExAC,gnomAD
rs782121319	p.Asp254Asn	missense variant	-	NC_000011.10:g.102840459C>T	ExAC,TOPMed,gnomAD
rs782121319	p.Asp254His	missense variant	-	NC_000011.10:g.102840459C>G	ExAC,TOPMed,gnomAD
rs1182056926	p.Asp254Val	missense variant	-	NC_000011.10:g.102840458T>A	TOPMed
COSM5929298	p.Asp255Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102840456C>T	NCI-TCGA Cosmic
rs1555005272	p.Ile256Val	missense variant	-	NC_000011.10:g.102840453T>C	gnomAD
rs1555005269	p.Ser261Phe	missense variant	-	NC_000011.10:g.102840437G>A	gnomAD
rs1555005267	p.Tyr263His	missense variant	-	NC_000011.10:g.102840432A>G	gnomAD
rs782403880	p.Tyr263Cys	missense variant	-	NC_000011.10:g.102840431T>C	ExAC,TOPMed,gnomAD
COSM3442730	p.Gly264Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102840252C>T	NCI-TCGA Cosmic
rs781846046	p.Pro265Ser	missense variant	-	NC_000011.10:g.102840250G>A	ExAC,gnomAD
rs782735258	p.Pro267Leu	missense variant	-	NC_000011.10:g.102840243G>A	ExAC,TOPMed,gnomAD
rs782139929	p.Asp268Val	missense variant	-	NC_000011.10:g.102840240T>A	ExAC,gnomAD
rs781866260	p.Ser269Thr	missense variant	-	NC_000011.10:g.102840238A>T	ExAC,gnomAD
rs782821084	p.Ser269Phe	missense variant	-	NC_000011.10:g.102840237G>A	ExAC,gnomAD
rs139187731	p.Pro270Arg	missense variant	-	NC_000011.10:g.102840234G>C	ESP,ExAC,TOPMed,gnomAD
rs782136205	p.Pro270Thr	missense variant	-	NC_000011.10:g.102840235G>T	ExAC,gnomAD
rs139187731	p.Pro270Leu	missense variant	-	NC_000011.10:g.102840234G>A	ESP,ExAC,TOPMed,gnomAD
rs200250895	p.Thr272Ile	missense variant	-	NC_000011.10:g.102840228G>A	ESP,ExAC,TOPMed,gnomAD
rs557944630	p.Thr272Ser	missense variant	-	NC_000011.10:g.102840229T>A	TOPMed
rs200250895	p.Thr272Asn	missense variant	-	NC_000011.10:g.102840228G>T	ESP,ExAC,TOPMed,gnomAD
rs781952098	p.Pro273Thr	missense variant	-	NC_000011.10:g.102840226G>T	ExAC,gnomAD
rs781952098	p.Pro273Ala	missense variant	-	NC_000011.10:g.102840226G>C	ExAC,gnomAD
rs782340869	p.Leu274ProPheSerTerUnkUnk	frameshift	-	NC_000011.10:g.102840222_102840223insG	NCI-TCGA,NCI-TCGA Cosmic
rs1489524712	p.Val275Leu	missense variant	-	NC_000011.10:g.102840220C>A	TOPMed
rs1195022030	p.Val275Ala	missense variant	-	NC_000011.10:g.102840219A>G	TOPMed,gnomAD
rs146504505	p.Pro276Ser	missense variant	-	NC_000011.10:g.102840217G>A	ESP,ExAC,TOPMed,gnomAD
rs782326787	p.Pro276His	missense variant	-	NC_000011.10:g.102840216G>T	ExAC,gnomAD
rs782178458	p.Thr277Ser	missense variant	-	NC_000011.10:g.102840214T>A	ExAC,TOPMed,gnomAD
rs565138607	p.Thr277Met	missense variant	-	NC_000011.10:g.102840213G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs782178458	p.Thr277Ala	missense variant	-	NC_000011.10:g.102840214T>C	ExAC,TOPMed,gnomAD
rs1555005221	p.Glu278Gly	missense variant	-	NC_000011.10:g.102840210T>C	gnomAD
rs782642874	p.Pro279Ser	missense variant	-	NC_000011.10:g.102840208G>A	ExAC,TOPMed,gnomAD
rs782642874	p.Pro279Thr	missense variant	-	NC_000011.10:g.102840208G>T	ExAC,TOPMed,gnomAD
COSM3442727	p.Pro279Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102840207G>A	NCI-TCGA Cosmic
rs782558947	p.Val280Ala	missense variant	-	NC_000011.10:g.102840204A>G	ExAC,TOPMed,gnomAD
rs1555005218	p.Val280Ile	missense variant	-	NC_000011.10:g.102840205C>T	gnomAD
rs1156528651	p.Pro281Ser	missense variant	-	NC_000011.10:g.102840202G>A	TOPMed,gnomAD
rs782700324	p.Glu283Gly	missense variant	-	NC_000011.10:g.102840195T>C	ExAC,gnomAD
rs782700324	p.Glu283Ala	missense variant	-	NC_000011.10:g.102840195T>G	ExAC,gnomAD
rs1420146151	p.Pro284Arg	missense variant	-	NC_000011.10:g.102840192G>C	TOPMed
rs369959225	p.Pro284Thr	missense variant	-	NC_000011.10:g.102840193G>T	ESP,ExAC,TOPMed,gnomAD
rs149156238	p.Thr286Met	missense variant	-	NC_000011.10:g.102840186G>A	ESP,ExAC,TOPMed,gnomAD
rs1555005209	p.Ala288Asp	missense variant	-	NC_000011.10:g.102840180G>T	gnomAD
rs1238621767	p.Ala288Thr	missense variant	-	NC_000011.10:g.102840181C>T	TOPMed
rs782130715	p.Asn289Ser	missense variant	-	NC_000011.10:g.102840177T>C	ExAC,gnomAD
rs781987329	p.Cys290Trp	missense variant	-	NC_000011.10:g.102840173A>C	ExAC,gnomAD
rs782812551	p.Pro292Ala	missense variant	-	NC_000011.10:g.102840169G>C	ExAC,TOPMed,gnomAD
rs1356291876	p.Ala293Thr	missense variant	-	NC_000011.10:g.102840166C>T	TOPMed
rs375381761	p.Leu294Trp	missense variant	-	NC_000011.10:g.102840162A>C	ESP,TOPMed,gnomAD
rs782356418	p.Leu294Phe	missense variant	-	NC_000011.10:g.102840161C>A	ExAC,TOPMed,gnomAD
rs1555005201	p.Asp297Val	missense variant	-	NC_000011.10:g.102840153T>A	gnomAD
rs1555005198	p.Ala298Val	missense variant	-	NC_000011.10:g.102840150G>A	gnomAD
rs782380049	p.Ser300Thr	missense variant	-	NC_000011.10:g.102840144C>G	ExAC,gnomAD
rs782302199	p.Thr301Ile	missense variant	-	NC_000011.10:g.102840141G>A	ExAC,gnomAD
rs916359137	p.Arg303Lys	missense variant	-	NC_000011.10:g.102840135C>T	TOPMed,gnomAD
rs528818883	p.Gly304Ter	stop gained	-	NC_000011.10:g.102840133C>A	1000Genomes,ExAC,gnomAD
rs782446614	p.Gly304Val	missense variant	-	NC_000011.10:g.102840132C>A	ExAC,gnomAD
NCI-TCGA novel	p.Glu305Lys	missense variant	-	NC_000011.10:g.102840130C>T	NCI-TCGA
rs992330140	p.Ile308Thr	missense variant	-	NC_000011.10:g.102840120A>G	gnomAD
rs782621390	p.Phe309Ser	missense variant	-	NC_000011.10:g.102840117A>G	ExAC,TOPMed,gnomAD
rs782621390	p.Phe309Tyr	missense variant	-	NC_000011.10:g.102840117A>T	ExAC,TOPMed,gnomAD
rs1555005193	p.Asp311Gly	missense variant	-	NC_000011.10:g.102840111T>C	gnomAD
rs140614141	p.Arg312Ser	missense variant	-	NC_000011.10:g.102839243C>A	ESP,ExAC,TOPMed,gnomAD
rs147533686	p.Arg316Cys	missense variant	-	NC_000011.10:g.102839233G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs147533686	p.Arg316Ser	missense variant	-	NC_000011.10:g.102839233G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs782643785	p.Arg316His	missense variant	-	NC_000011.10:g.102839232C>T	ExAC,TOPMed,gnomAD
rs782643785	p.Arg316Leu	missense variant	-	NC_000011.10:g.102839232C>A	ExAC,TOPMed,gnomAD
rs782382218	p.Lys317Arg	missense variant	-	NC_000011.10:g.102839229T>C	ExAC,gnomAD
COSM922294	p.Ser318Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102839226G>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Leu319Ile	missense variant	-	NC_000011.10:g.102839224G>T	NCI-TCGA
rs782666264	p.Leu319Pro	missense variant	-	NC_000011.10:g.102839223A>G	ExAC,gnomAD
rs782666264	p.Leu319His	missense variant	-	NC_000011.10:g.102839223A>T	ExAC,gnomAD
rs367715190	p.Lys321Arg	missense variant	-	NC_000011.10:g.102839217T>C	ESP,ExAC,TOPMed,gnomAD
rs146875246	p.Lys321Asn	missense variant	-	NC_000011.10:g.102839216C>A	ESP,ExAC,TOPMed,gnomAD
rs782598544	p.Leu322Phe	missense variant	-	NC_000011.10:g.102839215G>A	ExAC,TOPMed,gnomAD
rs782598544	p.Leu322Val	missense variant	-	NC_000011.10:g.102839215G>C	ExAC,TOPMed,gnomAD
rs781850506	p.Pro324Thr	missense variant	-	NC_000011.10:g.102839209G>T	ExAC,TOPMed,gnomAD
rs781850506	p.Pro324Ser	missense variant	-	NC_000011.10:g.102839209G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu325Gln	missense variant	-	NC_000011.10:g.102839206C>G	NCI-TCGA
rs368598390	p.His327Arg	missense variant	-	NC_000011.10:g.102839199T>C	ESP,ExAC,TOPMed,gnomAD
rs1382056600	p.Leu328Ser	missense variant	-	NC_000011.10:g.102839196A>G	TOPMed
COSM1350411	p.Leu328Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102839195C>A	NCI-TCGA Cosmic
rs782137329	p.Ile329Phe	missense variant	-	NC_000011.10:g.102839194T>A	ExAC,gnomAD
rs1420258170	p.Ile329Ser	missense variant	-	NC_000011.10:g.102839193A>C	TOPMed,gnomAD
NCI-TCGA novel	p.Ser330Phe	missense variant	-	NC_000011.10:g.102839190G>A	NCI-TCGA
rs1555005058	p.Ser330Thr	missense variant	-	NC_000011.10:g.102839191A>T	gnomAD
rs527842934	p.Trp333Arg	missense variant	-	NC_000011.10:g.102839182A>G	ExAC,TOPMed
rs782108389	p.Pro334Thr	missense variant	-	NC_000011.10:g.102839179G>T	ExAC,gnomAD
COSM1127950	p.Pro334Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102839179G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ser335Tyr	missense variant	-	NC_000011.10:g.102839175G>T	NCI-TCGA
rs139072785	p.Ser335Pro	missense variant	-	NC_000011.10:g.102839176A>G	ESP,ExAC,TOPMed,gnomAD
rs782395032	p.Pro337Ser	missense variant	-	NC_000011.10:g.102839170G>A	ExAC,gnomAD
rs200470692	p.Ser338Leu	missense variant	-	NC_000011.10:g.102839166G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs376007624	p.Val340Met	missense variant	-	NC_000011.10:g.102839161C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
COSM6066995	p.Val340Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102839161C>A	NCI-TCGA Cosmic
rs782616828	p.Asp341Val	missense variant	-	NC_000011.10:g.102839157T>A	ExAC,gnomAD
rs912160925	p.Ala342Asp	missense variant	-	NC_000011.10:g.102839154G>T	TOPMed
rs782261578	p.Ala343Thr	missense variant	-	NC_000011.10:g.102839152C>T	ExAC,TOPMed,gnomAD
rs782558227	p.Tyr344His	missense variant	-	NC_000011.10:g.102839149A>G	ExAC,TOPMed,gnomAD
rs782558227	p.Tyr344Asn	missense variant	-	NC_000011.10:g.102839149A>T	ExAC,TOPMed,gnomAD
rs201409153	p.Tyr344Cys	missense variant	-	NC_000011.10:g.102839148T>C	1000Genomes,TOPMed
COSM3868289	p.Glu345Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102839146C>T	NCI-TCGA Cosmic
rs782267524	p.Val346Phe	missense variant	-	NC_000011.10:g.102839143C>A	ExAC,TOPMed,gnomAD
rs1555005040	p.Thr347Ile	missense variant	-	NC_000011.10:g.102839139G>A	gnomAD
rs552851744	p.Ser348Arg	missense variant	-	NC_000011.10:g.102839135G>T	1000Genomes,ExAC,gnomAD
rs782438889	p.Lys349Asn	missense variant	-	NC_000011.10:g.102839132C>A	ExAC,gnomAD
rs1555005037	p.Asp350Glu	missense variant	-	NC_000011.10:g.102839129G>T	gnomAD
COSM4401233	p.Asp350Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102839131C>T	NCI-TCGA Cosmic
rs536550929	p.Val352Phe	missense variant	-	NC_000011.10:g.102839125C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs536550929	p.Val352Ile	missense variant	-	NC_000011.10:g.102839125C>T	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe355Ser	missense variant	-	NC_000011.10:g.102839115A>G	NCI-TCGA
rs782524617	p.Phe355Cys	missense variant	-	NC_000011.10:g.102839115A>C	ExAC,gnomAD
rs369213425	p.Gln359Pro	missense variant	-	NC_000011.10:g.102838704T>G	TOPMed
rs1555004965	p.Phe360Leu	missense variant	-	NC_000011.10:g.102838700G>T	gnomAD
NCI-TCGA novel	p.Trp361Cys	missense variant	-	NC_000011.10:g.102838697C>A	NCI-TCGA
rs1555004963	p.Trp361Arg	missense variant	-	NC_000011.10:g.102838699A>G	gnomAD
rs782487861	p.Gly365Arg	missense variant	-	NC_000011.10:g.102838687C>T	ExAC,gnomAD
rs1555004961	p.Gly365Glu	missense variant	-	NC_000011.10:g.102838686C>T	gnomAD
rs782640978	p.Val368Ala	missense variant	-	NC_000011.10:g.102838677A>G	ExAC,gnomAD
rs142121549	p.Arg369Ter	stop gained	-	NC_000011.10:g.102838675G>A	ESP,ExAC,TOPMed,gnomAD
rs781894748	p.Arg369Gln	missense variant	-	NC_000011.10:g.102838674C>T	ExAC,TOPMed,gnomAD
rs1555004956	p.Tyr372Ter	stop gained	-	NC_000011.10:g.102838664G>T	gnomAD
rs1555004957	p.Tyr372Cys	missense variant	-	NC_000011.10:g.102838665T>C	gnomAD
rs782730264	p.Pro373Ala	missense variant	-	NC_000011.10:g.102838663G>C	ExAC,gnomAD
rs1284957979	p.Arg374Ile	missense variant	-	NC_000011.10:g.102838659C>A	TOPMed
COSM3415430	p.Gly375Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102838656C>T	NCI-TCGA Cosmic
rs41516350	p.His377Gln	missense variant	-	NC_000011.10:g.102838649G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs782433018	p.His377Tyr	missense variant	-	NC_000011.10:g.102838651G>A	ExAC,TOPMed,gnomAD
rs1245134952	p.Thr378Ile	missense variant	-	NC_000011.10:g.102838647G>A	TOPMed,gnomAD
rs1555004947	p.Gly380Ser	missense variant	-	NC_000011.10:g.102838642C>T	gnomAD
rs201667769	p.Phe381Leu	missense variant	-	NC_000011.10:g.102838637G>C	ExAC,TOPMed,gnomAD
rs1555004944	p.Pro382Leu	missense variant	-	NC_000011.10:g.102838635G>A	gnomAD
rs1555004945	p.Pro382Ser	missense variant	-	NC_000011.10:g.102838636G>A	gnomAD
NCI-TCGA novel	p.Val385Leu	missense variant	-	NC_000011.10:g.102838627C>A	NCI-TCGA
rs202217886	p.Val385Met	missense variant	-	NC_000011.10:g.102838627C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs202217886	p.Val385Leu	missense variant	-	NC_000011.10:g.102838627C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Asp389Tyr	missense variant	-	NC_000011.10:g.102838615C>A	NCI-TCGA
rs1555004939	p.Asp389Asn	missense variant	-	NC_000011.10:g.102838615C>T	gnomAD
rs782213429	p.Ala390Thr	missense variant	-	NC_000011.10:g.102838612C>T	ExAC,gnomAD
rs1162092449	p.Ala390Val	missense variant	-	NC_000011.10:g.102838611G>A	TOPMed
rs1555004936	p.Ala391Thr	missense variant	-	NC_000011.10:g.102838609C>T	gnomAD
rs185081958	p.Ala391Asp	missense variant	-	NC_000011.10:g.102838608G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs185081958	p.Ala391Val	missense variant	-	NC_000011.10:g.102838608G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs782671460	p.Ile392Thr	missense variant	-	NC_000011.10:g.102838605A>G	ExAC,TOPMed,gnomAD
rs782671460	p.Ile392Ser	missense variant	-	NC_000011.10:g.102838605A>C	ExAC,TOPMed,gnomAD
COSM3442724	p.Glu396Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102838594C>T	NCI-TCGA Cosmic
rs981991768	p.Lys397Asn	missense variant	-	NC_000011.10:g.102838589C>A	-
rs1330316570	p.Asn398Lys	missense variant	-	NC_000011.10:g.102838586G>C	TOPMed
rs373335227	p.Tyr401His	missense variant	-	NC_000011.10:g.102838579A>G	ESP,gnomAD
NCI-TCGA novel	p.Tyr401Asp	missense variant	-	NC_000011.10:g.102838579A>C	NCI-TCGA
NCI-TCGA novel	p.Phe402Leu	missense variant	-	NC_000011.10:g.102838574G>T	NCI-TCGA
rs782593797	p.Phe403Leu	missense variant	-	NC_000011.10:g.102838571A>T	ExAC,TOPMed,gnomAD
rs782182277	p.Phe403Cys	missense variant	-	NC_000011.10:g.102838572A>C	ExAC,gnomAD
rs782182277	p.Phe403Ser	missense variant	-	NC_000011.10:g.102838572A>G	ExAC,gnomAD
rs1280008452	p.Trp409Ter	stop gained	-	NC_000011.10:g.102838553C>T	TOPMed
rs1378359129	p.Arg410Ter	stop gained	-	NC_000011.10:g.102838552T>A	TOPMed
COSM428293	p.Asp412His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102837397C>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Glu413Asp	missense variant	-	NC_000011.10:g.102837392C>G	NCI-TCGA
rs782608620	p.Glu413Lys	missense variant	-	NC_000011.10:g.102837394C>T	ExAC,gnomAD
NCI-TCGA novel	p.Lys414Asn	missense variant	-	NC_000011.10:g.102837389C>A	NCI-TCGA
rs1555004756	p.Arg415Gly	missense variant	-	NC_000011.10:g.102837388T>C	gnomAD
rs371658363	p.Ser417Pro	missense variant	-	NC_000011.10:g.102837382A>G	ESP
rs1357499164	p.Met418Thr	missense variant	-	NC_000011.10:g.102837378A>G	TOPMed,gnomAD
NCI-TCGA novel	p.Glu419Lys	missense variant	-	NC_000011.10:g.102837376C>T	NCI-TCGA
rs1555004751	p.Glu419Gln	missense variant	-	NC_000011.10:g.102837376C>G	gnomAD
rs377586699	p.Gly421Asp	missense variant	-	NC_000011.10:g.102837369C>T	ESP,ExAC,TOPMed,gnomAD
rs1555004748	p.Phe422Leu	missense variant	-	NC_000011.10:g.102837367A>G	gnomAD
rs539243624	p.Lys424Arg	missense variant	-	NC_000011.10:g.102837360T>C	gnomAD
NCI-TCGA novel	p.Gln425Glu	missense variant	-	NC_000011.10:g.102837358G>C	NCI-TCGA
rs1555004742	p.Ile426Thr	missense variant	-	NC_000011.10:g.102837354A>G	gnomAD
NCI-TCGA novel	p.Glu428Ter	stop gained	-	NC_000011.10:g.102837349C>A	NCI-TCGA
rs782820652	p.Glu428Gly	missense variant	-	NC_000011.10:g.102837348T>C	ExAC,gnomAD
rs1555004741	p.Glu428Lys	missense variant	-	NC_000011.10:g.102837349C>T	gnomAD
rs1555004739	p.Pro431Thr	missense variant	-	NC_000011.10:g.102837340G>T	gnomAD
rs781807154	p.Asp434Tyr	missense variant	-	NC_000011.10:g.102837331C>A	ExAC,gnomAD
rs782102554	p.Ile437Thr	missense variant	-	NC_000011.10:g.102837321A>G	ExAC,gnomAD
rs1555004734	p.Ala439Val	missense variant	-	NC_000011.10:g.102837315G>A	gnomAD
rs1555004732	p.Phe441Ile	missense variant	-	NC_000011.10:g.102837310A>T	TOPMed
rs1347820056	p.Glu443Ala	missense variant	-	NC_000011.10:g.102837303T>G	TOPMed,gnomAD
rs1347820056	p.Glu443Gly	missense variant	-	NC_000011.10:g.102837303T>C	TOPMed,gnomAD
NCI-TCGA novel	p.Phe444Cys	missense variant	-	NC_000011.10:g.102837300A>C	NCI-TCGA
rs781997796	p.Gly445Trp	missense variant	-	NC_000011.10:g.102837298C>A	ExAC,gnomAD
rs782731267	p.Gly445Ala	missense variant	-	NC_000011.10:g.102836226C>G	ExAC,gnomAD
rs1555004526	p.Phe446Leu	missense variant	-	NC_000011.10:g.102836222G>T	gnomAD
rs1555004527	p.Phe446Leu	missense variant	-	NC_000011.10:g.102836224A>G	gnomAD
NCI-TCGA novel	p.Phe447Leu	missense variant	-	NC_000011.10:g.102836219A>C	NCI-TCGA
rs782074937	p.Tyr448His	missense variant	-	NC_000011.10:g.102836218A>G	ExAC,gnomAD
rs1252024017	p.Phe449Leu	missense variant	-	NC_000011.10:g.102836213G>T	TOPMed,gnomAD
rs1555004525	p.Thr451Ala	missense variant	-	NC_000011.10:g.102836209T>C	gnomAD
rs561710994	p.Gly452Val	missense variant	-	NC_000011.10:g.102836205C>A	1000Genomes,ExAC,gnomAD
rs1415691035	p.Leu456Trp	missense variant	-	NC_000011.10:g.102836193A>C	TOPMed
rs782025917	p.Glu457Lys	missense variant	-	NC_000011.10:g.102836191C>T	ExAC,gnomAD
rs1169574624	p.Phe458Ser	missense variant	-	NC_000011.10:g.102836187A>G	TOPMed
rs782178682	p.Phe458Leu	missense variant	-	NC_000011.10:g.102836186A>T	ExAC,TOPMed,gnomAD
rs782625834	p.Asp459Glu	missense variant	-	NC_000011.10:g.102836183G>T	ExAC,gnomAD
rs1555004520	p.Asp459Tyr	missense variant	-	NC_000011.10:g.102836185C>A	gnomAD
rs780504353	p.Pro460Ser	missense variant	-	NC_000011.10:g.102836182G>A	-
rs1555004517	p.Ala462Gly	missense variant	-	NC_000011.10:g.102836175G>C	gnomAD
NCI-TCGA novel	p.Lys463Asn	missense variant	-	NC_000011.10:g.102836171C>A	NCI-TCGA
COSM4403164	p.Lys464Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102836169T>G	NCI-TCGA Cosmic
rs1555004516	p.Val465Met	missense variant	-	NC_000011.10:g.102836167C>T	gnomAD
NCI-TCGA novel	p.His467Gln	missense variant	-	NC_000011.10:g.102836159G>T	NCI-TCGA
rs567971149	p.Thr468Ser	missense variant	-	NC_000011.10:g.102836157G>C	1000Genomes,ExAC,gnomAD
COSM922292	p.Thr468Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000011.10:g.102836157G>A	NCI-TCGA Cosmic
rs1440053590	p.Lys470Arg	missense variant	-	NC_000011.10:g.102836151T>C	TOPMed
rs138229802	p.Ser471Asn	missense variant	-	NC_000011.10:g.102836148C>T	ESP,TOPMed
rs138229802	p.Ser471Thr	missense variant	-	NC_000011.10:g.102836148C>G	ESP,TOPMed
rs1414397533	p.Ser473Ile	missense variant	-	NC_000011.10:g.102836142C>A	TOPMed
rs782683357	p.Trp474Arg	missense variant	-	NC_000011.10:g.102836140A>G	ExAC,gnomAD
rs1291730776	p.Ter478Arg	stop lost	-	NC_000011.10:g.102836128A>G	TOPMed

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0001342	Acute periodontitis	disease	BEFREE
C0001418	Adenocarcinoma	group	BEFREE
C0001430	Adenoma	group	LHGDN
C0002395	Alzheimer's Disease	disease	BEFREE
C0002726	Amyloidosis	disease	BEFREE;LHGDN
C0002893	Refractory anemias	disease	BEFREE
C0002940	Aneurysm	phenotype	BEFREE
C0003486	Aortic Aneurysm	disease	BEFREE
C0003850	Arteriosclerosis	disease	BEFREE;LHGDN
C0003855	Arteriovenous fistula	phenotype	BEFREE
C0003857	Congenital arteriovenous malformation	disease	BEFREE
C0003862	Arthralgia	phenotype	BEFREE
C0003864	Arthritis	disease	BEFREE;LHGDN
C0003865	Arthritis, Adjuvant-Induced	disease	CTD_human
C0003872	Arthritis, Psoriatic	disease	BEFREE
C0003873	Rheumatoid Arthritis	disease	BEFREE;LHGDN
C0004114	Astrocytoma	disease	BEFREE;CTD_human
C0004135	Ataxia Telangiectasia	disease	BEFREE
C0004153	Atherosclerosis	disease	BEFREE;LHGDN
C0004623	Bacterial Infections	group	BEFREE
C0004779	Basal Cell Nevus Syndrome	disease	BEFREE
C0004936	Mental disorders	group	BEFREE
C0005586	Bipolar Disorder	disease	BEFREE;PSYGENET
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE
C0005940	Bone Diseases	group	BEFREE
C0006111	Brain Diseases	group	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE;CTD_human
C0007102	Malignant tumor of colon	disease	BEFREE
C0007103	Malignant neoplasm of endometrium	disease	BEFREE
C0007107	Malignant neoplasm of larynx	disease	BEFREE
C0007112	Adenocarcinoma of prostate	disease	BEFREE
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE
C0007134	Renal Cell Carcinoma	disease	BEFREE;LHGDN
C0007137	Squamous cell carcinoma	disease	BEFREE;LHGDN
C0007193	Cardiomyopathy, Dilated	group	LHGDN
C0007222	Cardiovascular Diseases	group	LHGDN
C0007273	Carotid Artery Diseases	group	LHGDN
C0007282	Carotid Stenosis	disease	BEFREE
C0007302	Cartilage Diseases	group	RGD
C0007570	Celiac Disease	disease	BEFREE
C0007758	Cerebellar Ataxia	phenotype	BEFREE
C0007820	Cerebrovascular Disorders	group	BEFREE
C0007847	Malignant tumor of cervix	disease	BEFREE
C0008149	Chlamydia Infections	group	BEFREE
C0008312	Primary biliary cirrhosis	disease	RGD
C0008479	Chondrosarcoma	disease	LHGDN
C0009324	Ulcerative Colitis	disease	BEFREE
C0009402	Colorectal Carcinoma	disease	BEFREE
C0009404	Colorectal Neoplasms	group	BEFREE;LHGDN
C0010051	Coronary Aneurysm	disease	BEFREE
C0010054	Coronary Arteriosclerosis	disease	BEFREE;CTD_human
C0010068	Coronary heart disease	disease	BEFREE;CTD_human
C0010072	Coronary Thrombosis	disease	BEFREE
C0010073	Coronary Artery Vasospasm	disease	BEFREE
C0010346	Crohn Disease	disease	BEFREE;LHGDN
C0010495	Cutis Laxa	disease	BEFREE
C0011265	Presenile dementia	disease	BEFREE
C0011603	Dermatitis	disease	LHGDN
C0011608	Dermatitis Herpetiformis	disease	BEFREE
C0011644	Scleroderma	disease	BEFREE
C0011847	Diabetes	disease	BEFREE
C0011849	Diabetes Mellitus	group	BEFREE
C0011854	Diabetes Mellitus, Insulin-Dependent	disease	BEFREE
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	disease	BEFREE;RGD
C0011881	Diabetic Nephropathy	disease	BEFREE
C0011884	Diabetic Retinopathy	disease	BEFREE
C0012359	Pathological Dilatation	phenotype	LHGDN
C0013295	Duodenal Ulcer	disease	BEFREE
C0014175	Endometriosis	disease	BEFREE;LHGDN
C0016169	pathologic fistula	phenotype	BEFREE
C0017152	Gastritis	disease	BEFREE
C0017168	Gastroesophageal reflux disease	disease	BEFREE
C0017563	Gingival Diseases	group	BEFREE
C0017601	Glaucoma	disease	BEFREE
C0017636	Glioblastoma	disease	BEFREE
C0017638	Glioma	disease	BEFREE
C0017658	Glomerulonephritis	disease	RGD
C0018799	Heart Diseases	group	BEFREE
C0018801	Heart failure	disease	BEFREE
C0018802	Congestive heart failure	disease	BEFREE
C0018995	Hemochromatosis	disease	BEFREE
C0019163	Hepatitis B	disease	BEFREE;LHGDN
C0019189	Hepatitis, Chronic	disease	BEFREE
C0019562	Von Hippel-Lindau Syndrome	disease	BEFREE
C0020429	Hyperalgesia	phenotype	CTD_human
C0020445	Hypercholesterolemia, Familial	disease	BEFREE
C0020473	Hyperlipidemia	disease	LHGDN
C0020538	Hypertensive disease	group	BEFREE;LHGDN
C0021368	Inflammation	phenotype	LHGDN
C0021390	Inflammatory Bowel Diseases	group	BEFREE;LHGDN
C0022548	Keloid	phenotype	BEFREE
C0022602	Actinic keratosis	disease	BEFREE
C0023267	Fibroid Tumor	group	BEFREE
C0023646	Lichen Planus	disease	LHGDN
C0023890	Liver Cirrhosis	disease	BEFREE;LHGDN
C0023892	Biliary cirrhosis	disease	RGD
C0023895	Liver diseases	group	LHGDN
C0023903	Liver neoplasms	group	BEFREE
C0024117	Chronic Obstructive Airway Disease	disease	BEFREE;GWASCAT
C0024121	Lung Neoplasms	group	LHGDN
C0024232	Lymphatic Metastasis	disease	BEFREE;LHGDN
C0024299	Lymphoma	group	LHGDN
C0024305	Lymphoma, Non-Hodgkin	disease	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0024814	Marinesco-Sjogren syndrome	disease	BEFREE
C0025202	melanoma	disease	BEFREE;LHGDN
C0026267	Mitral Valve Prolapse Syndrome	disease	BEFREE
C0026640	Mouth Neoplasms	group	LHGDN
C0026654	Moyamoya Disease	disease	BEFREE
C0026691	Mucocutaneous Lymph Node Syndrome	disease	BEFREE;LHGDN
C0026769	Multiple Sclerosis	disease	BEFREE;LHGDN
C0027051	Myocardial Infarction	disease	BEFREE;LHGDN
C0027092	Myopia	disease	BEFREE
C0027626	Neoplasm Invasiveness	phenotype	CTD_human
C0027627	Neoplasm Metastasis	phenotype	BEFREE;LHGDN
C0027651	Neoplasms	group	BEFREE
C0027697	Nephritis	disease	BEFREE
C0028259	Nodule	phenotype	BEFREE
C0028754	Obesity	disease	BEFREE
C0029172	Oral Submucous Fibrosis	disease	BEFREE
C0029408	Degenerative polyarthritis	disease	BEFREE;LHGDN
C0029421	Osteochondritis Dissecans	disease	LHGDN
C0029925	Ovarian Carcinoma	disease	BEFREE
C0030193	Pain	phenotype	BEFREE
C0030567	Parkinson Disease	disease	BEFREE
C0030805	Bullous pemphigoid	disease	BEFREE
C0031028	Periapical Diseases	group	BEFREE
C0031090	Periodontal Diseases	group	BEFREE
C0031099	Periodontitis	disease	BEFREE;RGD
C0031106	Periodontitis, Juvenile	disease	BEFREE
C0031117	Peripheral Neuropathy	group	CTD_human
C0032273	Pneumoconiosis	disease	LHGDN
C0032285	Pneumonia	disease	BEFREE
C0032927	Precancerous Conditions	group	BEFREE
C0032962	Pregnancy Complications	group	BEFREE
C0033999	Pterygium	disease	BEFREE
C0034069	Pulmonary Fibrosis	disease	BEFREE
C0034152	Henoch-Schoenlein Purpura	disease	BEFREE
C0034951	Refractive Errors	group	BEFREE
C0035235	Respiratory Syncytial Virus Infections	group	BEFREE
C0035335	Retinoblastoma	disease	BEFREE
C0036341	Schizophrenia	disease	BEFREE;PSYGENET
C0036421	Systemic Scleroderma	disease	BEFREE
C0036439	Scoliosis, unspecified	phenotype	LHGDN
C0036690	Septicemia	disease	BEFREE
C0038013	Ankylosing spondylitis	disease	BEFREE;LHGDN
C0038358	Gastric ulcer	disease	RGD
C0038454	Cerebrovascular accident	group	BEFREE
C0038525	Subarachnoid Hemorrhage	disease	BEFREE
C0039103	Synovitis	disease	BEFREE
C0039263	Takayasu Arteritis	disease	LHGDN
C0039483	Giant Cell Arteritis	disease	BEFREE
C0039685	Tetralogy of Fallot	disease	BEFREE
C0040021	Thromboangiitis Obliterans	disease	LHGDN
C0041296	Tuberculosis	disease	BEFREE
C0041582	Ulcer	disease	BEFREE
C0042133	Uterine Fibroids	group	BEFREE
C0042345	Varicosity	disease	BEFREE
C0079474	Hallopeau-Siemens Disease	disease	BEFREE
C0085437	Meningitis, Bacterial	group	BEFREE
C0149931	Migraine Disorders	group	BEFREE
C0151517	Complete atrioventricular block	disease	BEFREE
C0151699	Intracranial Hemorrhages	group	BEFREE
C0151936	Disorder of tendon	group	BEFREE
C0152164	Cyclical vomiting syndrome (disorder)	disease	BEFREE
C0153676	Secondary malignant neoplasm of lung	disease	BEFREE
C0154051	Hemangioma of retina	disease	BEFREE
C0155094	Corneal pannus	disease	BEFREE
C0155626	Acute myocardial infarction	disease	BEFREE
C0158266	Intervertebral Disc Degeneration	disease	BEFREE
C0158646	Cleft palate with cleft lip	disease	BEFREE
C0162323	Polyarthritis	disease	BEFREE
C0162566	Porphyria Cutanea Tarda	disease	BEFREE
C0162810	Cicatrix, Hypertrophic	phenotype	BEFREE
C0162820	Dermatitis, Allergic Contact	disease	RGD
C0162871	Aortic Aneurysm, Abdominal	disease	BEFREE;RGD
C0178874	Tumor Progression	phenotype	BEFREE
C0205768	Subependymal Giant Cell Astrocytoma	disease	CTD_human
C0206693	Medullary carcinoma	disease	BEFREE
C0206698	Cholangiocarcinoma	disease	BEFREE;LHGDN
C0206734	Hemangioblastoma	disease	BEFREE
C0220650	Metastatic malignant neoplasm to brain	disease	BEFREE
C0221775	Lumbar disc disease	disease	BEFREE
C0233514	Abnormal behavior	phenotype	BEFREE
C0235974	Pancreatic carcinoma	disease	BEFREE
C0237938	Gastrointestinal ulcer	disease	BEFREE
C0242231	Coronary Stenosis	disease	BEFREE
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0242698	Ventricular Dysfunction, Left	phenotype	LHGDN
C0243026	Sepsis	disease	BEFREE
C0263912	Rotator cuff syndrome	disease	BEFREE
C0266929	Chronic Periodontitis	disease	BEFREE
C0269102	Endometrioma	disease	BEFREE
C0271183	Severe myopia	disease	BEFREE
C0278883	Metastatic melanoma	disease	BEFREE
C0278996	Malignant Head and Neck Neoplasm	disease	BEFREE
C0279626	Squamous cell carcinoma of esophagus	disease	BEFREE
C0279628	Adenocarcinoma Of Esophagus	disease	BEFREE
C0280783	Juvenile Pilocytic Astrocytoma	disease	CTD_human
C0280785	Diffuse Astrocytoma	disease	CTD_human
C0302592	Cervix carcinoma	disease	BEFREE
C0333186	Restenosis	phenotype	BEFREE
C0333307	Superficial ulcer	phenotype	BEFREE
C0334533	Arteriovenous hemangioma	disease	BEFREE
C0334579	Anaplastic astrocytoma	disease	CTD_human
C0334580	Protoplasmic astrocytoma	disease	CTD_human
C0334581	Gemistocytic astrocytoma	disease	CTD_human
C0334582	Fibrillary Astrocytoma	disease	CTD_human
C0334583	Pilocytic Astrocytoma	disease	CTD_human
C0338070	Childhood Cerebral Astrocytoma	disease	CTD_human
C0339229	Superior limbic keratoconjunctivitis	disease	BEFREE
C0340629	Aortic aneurysm without mention of rupture NOS	disease	BEFREE
C0341299	Collagenous Sprue	disease	BEFREE
C0341439	Chronic liver disease	group	BEFREE
C0346429	Multiple malignancy	phenotype	BEFREE
C0346629	Malignant neoplasm of large intestine	disease	BEFREE
C0346647	Malignant neoplasm of pancreas	disease	BEFREE
C0349782	Ischemic cardiomyopathy	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0392885	High density lipoprotein measurement	phenotype	GWASDB
C0393819	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	disease	BEFREE
C0403416	Idiopathic crescentic glomerulonephritis	disease	RGD
C0409959	Osteoarthritis, Knee	disease	BEFREE
C0410606	Cervical Disc Degenerative Disorder	disease	RGD
C0458247	Allodynia	phenotype	CTD_human
C0476089	Endometrial Carcinoma	disease	BEFREE
C0497327	Dementia	disease	BEFREE;LHGDN
C0520459	Necrotizing Enterocolitis	disease	LHGDN
C0524909	Hepatitis B, Chronic	disease	BEFREE
C0547065	Mixed oligoastrocytoma	disease	CTD_human
C0555198	Malignant Glioma	disease	BEFREE
C0566602	Primary sclerosing cholangitis	disease	BEFREE
C0577631	Carotid Atherosclerosis	disease	BEFREE
C0595989	Carcinoma of larynx	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0598935	Tumor Initiation	phenotype	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE;CTD_human
C0684249	Carcinoma of lung	disease	BEFREE
C0684256	Bacterial sepsis	disease	BEFREE
C0685889	Splenic Hypoplasia	disease	BEFREE
C0685938	Malignant neoplasm of gastrointestinal tract	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0740394	Hyperuricemia	disease	BEFREE
C0741923	cardiac event	phenotype	BEFREE
C0741975	carotid disease	disease	BEFREE
C0745103	Hyperlipoproteinemia Type IIa	disease	BEFREE
C0750935	Cerebral Astrocytoma	disease	CTD_human
C0750936	Intracranial Astrocytoma	disease	CTD_human
C0751211	Hyperalgesia, Primary	phenotype	CTD_human
C0751212	Hyperalgesia, Secondary	phenotype	CTD_human
C0751213	Tactile Allodynia	phenotype	CTD_human
C0751214	Hyperalgesia, Thermal	phenotype	CTD_human
C0850666	Infection caused by Helicobacter pylori	disease	BEFREE
C0878693	Conjunctivochalasis	disease	BEFREE
C0948008	Ischemic stroke	disease	BEFREE
C0948089	Acute Coronary Syndrome	disease	BEFREE
C0948163	Leukoaraiosis	phenotype	LHGDN
C0948480	Coronary Restenosis	disease	BEFREE;CTD_human
C0971858	Arthritis, Collagen-Induced	disease	CTD_human
C0993582	Arthritis, Experimental	disease	CTD_human
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1168305	Corneal melt	disease	BEFREE
C1168401	Squamous cell carcinoma of the head and neck	disease	BEFREE
C1257931	Mammary Neoplasms, Human	group	CTD_human
C1261473	Sarcoma	group	LHGDN
C1275122	Familial multiple trichoepitheliomata	disease	BEFREE
C1290590	Hyperplastic tooth follicle	disease	BEFREE
C1302401	Adenoma of large intestine	disease	BEFREE
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1306889	Peripheral arterial occlusive disease	disease	BEFREE
C1334274	Invasive Carcinoma	phenotype	BEFREE
C1366911	Cerebral Cavernous Malformations 1	disease	BEFREE
C1458155	Mammary Neoplasms	group	BEFREE;CTD_human;LHGDN
C1527249	Colorectal Cancer	disease	BEFREE
C1527336	Sjogren's Syndrome	disease	BEFREE
C1561643	Chronic Kidney Diseases	group	BEFREE
C1565489	Renal Insufficiency	disease	BEFREE
C1566302	Preterm Premature Rupture of Fetal Membranes	disease	BEFREE
C1567741	Alport Syndrome	disease	BEFREE
C1568272	Tendinopathy	disease	BEFREE
C1568363	Tendinosis	disease	BEFREE
C1623038	Cirrhosis	disease	BEFREE
C1704230	Grade I Astrocytoma	disease	CTD_human
C1800706	Idiopathic Pulmonary Fibrosis	disease	BEFREE;CTD_human
C1866956	Aortic root dilation	disease	BEFREE
C1868675	PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	disease	RGD
C1883486	Uterine Corpus Cancer	disease	BEFREE
C1956346	Coronary Artery Disease	disease	BEFREE;CTD_human;LHGDN
C2004489	Regurgitation	phenotype	BEFREE
C2239176	Liver carcinoma	disease	BEFREE;LHGDN
C2931384	Moyamoya disease 1	disease	BEFREE
C2931822	Nasopharyngeal carcinoma	disease	BEFREE
C2936719	Mechanical Allodynia	phenotype	CTD_human
C2937358	Cerebral Hemorrhage	phenotype	CTD_human
C2939420	Metastatic Neoplasm	phenotype	BEFREE
C3495559	Juvenile arthritis	disease	BEFREE;LHGDN
C3714514	Infection	group	LHGDN
C3811653	Experimental Organism Basal Cell Carcinoma	phenotype	BEFREE
C3840085	Disorder of Achilles tendon	disease	BEFREE
C3887524	Skin Erosion	disease	BEFREE
C3888194	MIXED LINEAGE LEUKEMIA	disease	BEFREE
C4020848	Aneurysmal disease	disease	BEFREE
C4048328	cervical cancer	disease	BEFREE
C4082937	Necrotizing enterocolitis in fetus OR newborn	disease	BEFREE
C4255010	Non-ST Elevated Myocardial Infarction	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0004175	endopeptidase activity	IDA
GO:0004222	metalloendopeptidase activity	IBA
GO:0004252	serine-type endopeptidase activity	TAS
GO:0005515	protein binding	IPI
GO:0008233	peptidase activity	IDA
GO:0008237	metallopeptidase activity	IDA
GO:0008270	zinc ion binding	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0006508	proteolysis	IDA
GO:0010727	negative regulation of hydrogen peroxide metabolic process	IDA
GO:0019221	cytokine-mediated signaling pathway	TAS
GO:0022617	extracellular matrix disassembly	TAS
GO:0030198	extracellular matrix organization	IBA
GO:0030574	collagen catabolic process	IBA
GO:0030574	collagen catabolic process	TAS
GO:0031334	positive regulation of protein-containing complex assembly	IDA
GO:0071732	cellular response to nitric oxide	TAS
GO:0150077	regulation of neuroinflammatory response	TAS
GO:1903209	positive regulation of oxidative stress-induced cell death	ISS
GO:1904645	response to amyloid-beta	TAS

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	TAS
GO:0031012	extracellular matrix	IEA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1442490	Collagen degradation	TAS
R-HSA-1442490	Collagen degradation	IEA
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474228	Degradation of the extracellular matrix	IEA
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1474290	Collagen formation	TAS
R-HSA-1592389	Activation of Matrix Metalloproteinases	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-168256	Immune System	TAS
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	TAS
R-HSA-2179392	EGFR Transactivation by Gastrin	IEA
R-HSA-2179392	EGFR Transactivation by Gastrin	TAS
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	IEA
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	TAS
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	IEA
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	TAS
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9009391	Extra-nuclear estrogen signaling	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C540360	1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin	1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin results in decreased expression of MMP3 mRNA	19330880
C540360	1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin	1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin results in decreased expression of MMP3 protein	19330880
C082486	13-hydroxy-10-oxo-11-octadecenoic acid	13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [DDT results in increased expression of MMP3 mRNA]	20865247
C082486	13-hydroxy-10-oxo-11-octadecenoic acid	13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP3 mRNA]	20865247
D015056	1-Methyl-3-isobutylxanthine	TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]	23503329
D015056	1-Methyl-3-isobutylxanthine	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA	23503329
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP3 mRNA	28329830
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of MMP3 mRNA	15913567
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of MMP3 mRNA	25827057
C417207	2,2',4,6,6'-pentachlorobiphenyl	2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA	16778083; 29535049;
C417207	2,2',4,6,6'-pentachlorobiphenyl	2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 protein	29535049
C417207	2,2',4,6,6'-pentachlorobiphenyl	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]	16778083
C417207	2,2',4,6,6'-pentachlorobiphenyl	PD168393 inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]	29535049
C417207	2,2',4,6,6'-pentachlorobiphenyl	pyrazolanthrone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]	16778083
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]	16778083
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	19765281
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MMP3 mRNA	19114083
C010914	2,4-diaminotoluene	2,4-diaminotoluene results in increased expression of MMP3 mRNA	20713471
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	23328930
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP3 protein]	23328930
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of MMP3 protein]	23328930
C012796	2-butenal	2-butenal results in increased expression of MMP3 mRNA	20471460
C011506	2-methyl-4-isothiazolin-3-one	2-methyl-4-isothiazolin-3-one results in increased expression of MMP3 mRNA	30806763
C014464	3,4-dichloroaniline	3,4-dichloroaniline results in increased expression of MMP3 mRNA	24172598
C049246	3-hydroxypicolinic acid	3-hydroxypicolinic acid results in decreased activity of MMP3 protein	21189019
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	19765281
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of MMP3 mRNA	19561079
D015112	4-Nitroquinoline-1-oxide	4-Nitroquinoline-1-oxide results in increased expression of MMP3 mRNA	22561872
C034214	5-iodotubercidin	5-iodotubercidin results in increased expression of MMP3 mRNA	26953159
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] promotes the reaction [IL1B protein results in increased expression of MMP3 protein]	20426787
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP3 mRNA	20426787
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP3 protein	20426787
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MMP3 mRNA	20382639
D000082	Acetaminophen	Acetaminophen results in increased expression of MMP3 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of MMP3 mRNA	17562736
C006358	acetohydroxamic acid	acetohydroxamic acid binds to and results in decreased activity of MMP3 protein	15237990; 16522091;
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	10336562
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP3 protein]	17395008
D000336	Aerosols	Aerosols results in increased expression of MMP3 mRNA	29505817
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of MMP3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MMP3 mRNA	21641981; 22100608;
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP3 mRNA]	19022365
D000537	Aluminum Oxide	Aluminum Oxide results in increased expression of MMP3 mRNA	16488289
D000622	Aminolevulinic Acid	Aminolevulinic Acid affects the expression of MMP3 mRNA	12542540
D000622	Aminolevulinic Acid	Aminolevulinic Acid affects the expression of MMP3 protein	12542540
D000622	Aminolevulinic Acid	Sodium Azide inhibits the reaction [Aminolevulinic Acid affects the expression of MMP3 protein]	12542540
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MMP3 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	amphotericin B, deoxycholate drug combination results in increased expression of MMP3 mRNA	22863853
C078814	anandamide	anandamide results in increased expression of MMP3 mRNA	16330497
D000875	Anthralin	Anthralin results in decreased activity of MMP3 protein	23611293
D018501	Antirheumatic Agents	[Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of MMP3 protein	23146660
C015001	arsenite	arsenite results in decreased expression of MMP3 mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of MMP3 mRNA]	18929588
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in increased expression of MMP3 mRNA	24160326
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in increased expression of MMP3 mRNA	24160326
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in decreased expression of MMP3 mRNA	16251409
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in increased expression of MMP3 mRNA	23917077
D001241	Aspirin	Aspirin inhibits the reaction [Azoxymethane results in increased expression of MMP3 mRNA]	20043115
C049935	avobenzone	avobenzone results in decreased expression of MMP3 mRNA	31016361
D001379	Azathioprine	Azathioprine results in increased expression of MMP3 mRNA	22623647
C547126	AZM551248	AZM551248 results in decreased activity of MMP3 protein	22323515
C547126	AZM551248	AZM551248 results in increased expression of MMP3 mRNA	22323515
D001397	Azoxymethane	Aspirin inhibits the reaction [Azoxymethane results in increased expression of MMP3 mRNA]	20043115
D001397	Azoxymethane	Azoxymethane results in increased expression of MMP3 mRNA	20043115
D001554	Benzene	Benzene results in increased expression of MMP3 mRNA	19446245
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of MMP3 mRNA	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MMP3 mRNA	21632981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MMP3 mRNA	22228805
D001564	Benzo(a)pyrene	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP3 mRNA]	19022365
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MMP3 mRNA	19022365
C074212	bis(maltolato)oxovanadium(IV)	bis(maltolato)oxovanadium(IV) results in decreased expression of MMP3 mRNA	17696279
C006780	bisphenol A	bisphenol A results in increased expression of MMP3 mRNA	26604029
C006780	bisphenol A	bisphenol A inhibits the reaction [Estradiol results in decreased expression of MMP3 mRNA]	27312807
C006780	bisphenol A	bisphenol A affects the expression of MMP3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of MMP3 mRNA	29552716
C006780	bisphenol A	[enzacamene co-treated with octylmethoxycinnamate co-treated with bisphenol A co-treated with butylparaben] results in increased expression of MMP3 mRNA	25305543
D001761	Bleomycin	Bleomycin results in increased expression of MMP3 mRNA	28434932
D001761	Bleomycin	Dinoprostone inhibits the reaction [Bleomycin results in increased expression of MMP3 mRNA]	28434932
D001761	Bleomycin	MMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]	28434932
C086539	BQ 788	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
C038091	butylparaben	[enzacamene co-treated with octylmethoxycinnamate co-treated with bisphenol A co-treated with butylparaben] results in increased expression of MMP3 mRNA	25305543
D019256	Cadmium Chloride	Cadmium Chloride results in increased secretion of MMP3 protein	30572105
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of MMP3 mRNA	20360939
D002117	Calcitriol	Calcitriol results in increased expression of MMP3 mRNA	12040012; 16002434;
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MMP3 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP3 mRNA	15056808
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP3 mRNA	18481824; 31150632;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP3 protein	17094476
D002251	Carbon Tetrachloride	PLAU protein promotes the reaction [Carbon Tetrachloride results in increased expression of MMP3 mRNA]	18481824
D002251	Carbon Tetrachloride	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP3 mRNA]	31150632
C097658	CGS 27023A	CGS 27023A affects the activity of MMP3 protein	22017477
D002701	Chloramphenicol	Chloramphenicol results in increased expression of MMP3 mRNA	20338993
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP3 mRNA	20548288; 20938992;
D002809	Chondroitin Sulfates	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA	17605605
D002809	Chondroitin Sulfates	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA	20110869
D002809	Chondroitin Sulfates	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased secretion of MMP3 protein	20110869
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of MMP3 mRNA	30806763
D002939	Ciprofloxacin	Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]	12428247
D002939	Ciprofloxacin	Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]	12428247
D002939	Ciprofloxacin	Ciprofloxacin results in increased expression of MMP3 mRNA	12428247
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in increased expression of MMP3 mRNA	20705681
D002945	Cisplatin	MMP3 promoter polymorphism affects the susceptibility to [Fluorouracil co-treated with Cisplatin]	15102660
D002953	Citrinin	Citrinin results in increased expression of MMP3 mRNA	19361540
D002953	Citrinin	pyrazolanthrone inhibits the reaction [Citrinin results in increased expression of MMP3 mRNA]	19361540
D007464	Clioquinol	[Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP3 protein	16648635
D002994	Clofibrate	Clofibrate inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	16572457
D002994	Clofibrate	[Clofibrate promotes the reaction [IL1B protein results in increased expression of IL1RN mRNA]] which results in increased expression of MMP3 mRNA	16572457
D003035	Cobalt	TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]	23503329
D003035	Cobalt	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA	23503329
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	20110250; 22155307;
C007095	cobaltiprotoporphyrin	HMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]]	20110250
C007095	cobaltiprotoporphyrin	HMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]]	20110250
D003300	Copper	[Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP3 protein	16648635
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of MMP3 mRNA	24690739
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of MMP3 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of MMP3 mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	16807698
D003474	Curcumin	Curcumin results in increased expression of MMP3 mRNA	15713895; 18321735;
D003474	Curcumin	[Resveratrol co-treated with Curcumin] inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	19889203
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of MMP3 mRNA	15331540
D016572	Cyclosporine	Cyclosporine results in increased expression of MMP3 mRNA	20106945; 21632981;
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
D003634	DDT	13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [DDT results in increased expression of MMP3 mRNA]	20865247
D003634	DDT	DDT results in increased expression of MMP3 mRNA	20865247
D003634	DDT	zerumbone inhibits the reaction [DDT results in increased expression of MMP3 mRNA]	20865247
D003907	Dexamethasone	Dexamethasone inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	10336562
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	20858459
D003907	Dexamethasone	Dexamethasone results in decreased expression of MMP3 mRNA	25047013
D003907	Dexamethasone	TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]	23503329
D003907	Dexamethasone	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA	23503329
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of MMP3 mRNA	19285099; 20824662;
D016264	Dextran Sulfate	Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP3 mRNA]	19285099
C041517	dibenzo(a,l)pyrene	[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of MMP3 mRNA	17690111
C041517	dibenzo(a,l)pyrene	dibenzo(a,l)pyrene results in decreased expression of MMP3 mRNA	25908611
C503840	dieckol	dieckol results in decreased expression of MMP3 mRNA	19330880
C503840	dieckol	dieckol results in decreased expression of MMP3 protein	19330880
D004041	Dietary Fats	Dietary Fats results in decreased expression of MMP3 mRNA	18042831
D004041	Dietary Fats	[Ethanol co-treated with Dietary Fats] results in increased expression of MMP3 mRNA	21051528
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of MMP3 mRNA	20360939
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of MMP3 mRNA	20360939
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of MMP3 mRNA	22504913
D013196	Dihydrotestosterone	Dihydrotestosterone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of MMP3 mRNA	20146380
D015232	Dinoprostone	Dinoprostone inhibits the reaction [Bleomycin results in increased expression of MMP3 mRNA]	28434932
D015232	Dinoprostone	MMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]	28434932
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of MMP3 mRNA	24690739
D004237	Diuron	Diuron metabolite results in increased expression of MMP3 mRNA	24172598
D004237	Diuron	Diuron results in increased expression of MMP3 mRNA	25152437
C063533	dofetilide	dofetilide binds to MMP3 protein	21634430
D004317	Doxorubicin	Doxorubicin results in decreased expression of MMP3 mRNA	29803840
D004317	Doxorubicin	Doxorubicin results in increased expression of MMP3 mRNA	28710503
D004317	Doxorubicin	Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA]	28710503
D004317	Doxorubicin	NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA]	28710503
D004318	Doxycycline	Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	17267227
D004318	Doxycycline	Doxycycline results in decreased activity of MMP3 protein	17267227
D004318	Doxycycline	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MMP3 mRNA]	18089841
D013759	Dronabinol	Dronabinol results in increased expression of MMP3 mRNA	16330497
D004656	Enalapril	Enalapril results in decreased expression of MMP3 mRNA	25037058
D004726	Endosulfan	Endosulfan results in increased expression of MMP3 mRNA	28108160; 30090376;
D004726	Endosulfan	Endosulfan results in increased expression of MMP3 protein	28108160
D004726	Endosulfan	Endosulfan results in increased expression of MMP3 mRNA	29391264
C038939	enzacamene	[enzacamene co-treated with octylmethoxycinnamate co-treated with bisphenol A co-treated with butylparaben] results in increased expression of MMP3 mRNA	25305543
C472787	erucylphospho-N,N,N-trimethylpropylammonium	erucylphospho-N,N,N-trimethylpropylammonium results in increased expression of MMP3 mRNA	29464035
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased secretion of MMP3 protein	16009159
D004958	Estradiol	Estradiol inhibits the reaction [IL1B protein results in increased expression of MMP3 protein modified form]	22219637
D004958	Estradiol	Estradiol results in decreased expression of MMP3 mRNA	25878060
D004958	Estradiol	Estradiol results in increased expression of MMP3 mRNA	20106945
D004958	Estradiol	Estradiol results in increased secretion of MMP3 protein	16009159
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of MMP3 mRNA	17404688
D004958	Estradiol	bisphenol A inhibits the reaction [Estradiol results in decreased expression of MMP3 mRNA]	27312807
D004958	Estradiol	Estradiol results in decreased expression of MMP3 mRNA	19693291; 27312807;
D004958	Estradiol	Estradiol results in increased expression of MMP3 mRNA	19416213; 19484750;
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased expression of MMP3 mRNA]	19416213
D004967	Estrogens	[Estrogens co-treated with IL1B protein] results in increased expression of MMP3 mRNA	18570937
D004967	Estrogens	[Estrogens co-treated with Progesterone co-treated with IL1B protein] results in increased expression of MMP3 mRNA	18570937
D000431	Ethanol	CNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of MMP3 mRNA]	21863215
D000431	Ethanol	[Ethanol co-treated with Thioacetamide] results in increased expression of MMP3 mRNA	21863215
D000431	Ethanol	[Ethanol co-treated with Dietary Fats] results in increased expression of MMP3 mRNA	21051528
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of MMP3 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MMP3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MMP3 mRNA	17942748
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP3 protein	22085904
D005204	Farnesol	Farnesol results in increased expression of MMP3 mRNA	30806763
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP3 mRNA	28329830
D005472	Fluorouracil	MMP3 promoter polymorphism affects the susceptibility to [Fluorouracil co-treated with Cisplatin]	15102660
D005492	Folic Acid	Folic Acid affects the expression of MMP3 mRNA	17320366
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP3 mRNA	20548288; 20938992;
D005557	Formaldehyde	Formaldehyde results in decreased expression of MMP3 mRNA	28937961
D005557	Formaldehyde	Formaldehyde results in increased expression of MMP3 mRNA	27664576
C067584	formosanin C	formosanin C results in decreased expression of MMP3 protein	21304274
C007789	fucoidan	fucoidan inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	16364234
C069837	fullerene C60	fullerene C60 results in increased expression of MMP3 mRNA	20064541
C056507	gemcitabine	gemcitabine results in decreased expression of MMP3 protein	20531411
D019833	Genistein	Genistein results in decreased expression of MMP3 mRNA	22504913
D019833	Genistein	Genistein results in decreased expression of MMP3 protein	24552547
C007836	geraniol	geraniol results in increased expression of MMP3 mRNA	30806763
D005944	Glucosamine	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA	17605605
D005944	Glucosamine	Glucosamine analog inhibits the reaction [IL1B protein results in increased expression of MMP3]	15144122
D005944	Glucosamine	Glucosamine analog inhibits the reaction [IL1B results in increased expression of and results in increased secretion of MMP3 protein]	18080321
D005944	Glucosamine	Glucosamine analog inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]	18080321
D005944	Glucosamine	Glucosamine analog results in decreased expression of MMP3 mRNA	16300972
D005944	Glucosamine	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA	20110869
D005944	Glucosamine	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased secretion of MMP3 protein	20110869
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	17925024
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	17925024
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]	18340449
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 protein]	18340449
D005944	Glucosamine	Glucosamine results in decreased expression of and results in decreased activity of MMP3 protein	12801482
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	11229466
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]	17109745
D005944	Glucosamine	Glucosamine results in increased expression of MMP3 mRNA	17109745
D005944	Glucosamine	IL1B promotes the reaction [Glucosamine results in increased expression of MMP3 mRNA]	17109745
C065632	glucosamine 3-O-sulfate	glucosamine 3-O-sulfate results in decreased expression of MMP3 mRNA	16300972
D005947	Glucose	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP3	24840287
D005947	Glucose	Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP3]	24840287
C086566	glycitein	glycitein results in decreased expression of MMP3 mRNA	20188714
C086566	glycitein	glycitein results in decreased expression of MMP3 protein	20188714
D006046	Gold	Gold results in increased expression of MMP3 mRNA	24022940
C010176	halofuginone	halofuginone promotes the reaction [Thioacetamide results in increased expression of MMP3 mRNA]	16489207
C010176	halofuginone	halofuginone results in increased expression of MMP3 mRNA	16489207
C010176	halofuginone	halofuginone results in increased expression of MMP3 protein	16489207
D006820	Hyaluronic Acid	[Hyaluronic Acid co-treated with Resveratrol] results in decreased expression of MMP3 mRNA	23595953
D006861	Hydrogen Peroxide	CAT protein inhibits the reaction [[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP3 mRNA]	12538496
D006861	Hydrogen Peroxide	[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP3 mRNA	12538496
C031927	hydroquinone	hydroquinone affects the expression of MMP3 mRNA	15452088
C031927	hydroquinone	hydroquinone results in increased expression of MMP3 mRNA	31256213
D006877	Hydroxamic Acids	Hydroxamic Acids analog binds to and results in decreased activity of MMP3 protein	15237990
D007052	Ibuprofen	Ibuprofen inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	10336562
D007052	Ibuprofen	Ibuprofen results in increased expression of MMP3 mRNA	16580899
C041508	indeno(1,2,3-cd)pyrene	indeno(1,2,3-cd)pyrene results in decreased expression of MMP3 mRNA	26377693
D007213	Indomethacin	Indomethacin inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	10336562
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MMP3 mRNA	25613284
D007545	Isoproterenol	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MMP3 mRNA]	18089841
D007545	Isoproterenol	Isoproterenol results in increased expression of MMP3 mRNA	18089841; 20003209;
D007545	Isoproterenol	Isoproterenol results in increased expression of MMP3	12883319
D007545	Isoproterenol	SI 27 inhibits the reaction [Isoproterenol results in increased expression of MMP3]	12883319
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MMP3 mRNA	26324948
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MMP3 protein	26324948
D019344	Lactic Acid	Lactic Acid results in increased expression of MMP3 mRNA	30851411
D064704	Levofloxacin	Levofloxacin results in increased expression of MMP3 mRNA	23813946
D064704	Levofloxacin	Levofloxacin results in increased expression of MMP3 protein	23813946
C433788	lipopolysaccharide, E. coli O26-B6	lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP3 mRNA]	18986645
C433788	lipopolysaccharide, E. coli O26-B6	lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA	18986645
C433788	lipopolysaccharide, E. coli O26-B6	Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA]	18986645
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MMP3 protein	17303203
D008070	Lipopolysaccharides	Melitten inhibits the reaction [Lipopolysaccharides results in increased expression of MMP3 protein]	17303203
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MMP3 mRNA	25613284
D008148	Lovastatin	Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA]	28710503
C008316	maltol	maltol analog binds to and results in decreased activity of MMP3 protein	15237990
C008316	maltol	maltol binds to and results in decreased activity of MMP3 protein	16522091
D008345	Manganese	Manganese results in increased expression of MMP3 mRNA	26745496
C025340	manganese chloride	manganese chloride results in increased expression of MMP3 mRNA	26745496
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP3 protein]	17395008
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	manganese(III)-tetrakis(4-benzoic acid)porphyrin results in decreased expression of and results in decreased secretion of MMP3 protein	17395008
D061965	Matrix Metalloproteinase Inhibitors	Matrix Metalloproteinase Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	19765281
D061965	Matrix Metalloproteinase Inhibitors	Matrix Metalloproteinase Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	19765281
D019290	Megestrol Acetate	[Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP3 protein	22085904
D008555	Melitten	Melitten inhibits the reaction [Lipopolysaccharides results in increased expression of MMP3 protein]	17303203
C088155	methanandamide	methanandamide results in increased expression of MMP3 mRNA	16330497
C088155	methanandamide	methanandamide results in increased expression of MMP3 protein	16330497
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP3 mRNA	20548288; 20938992;
D008727	Methotrexate	[Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of MMP3 protein	23146660
D008727	Methotrexate	Methotrexate results in decreased expression of MMP3 mRNA	15476228
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of MMP3 mRNA	20713471
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of MMP3 mRNA	17412507
D000077555	Methylprednisolone Acetate	Methylprednisolone Acetate results in decreased expression of MMP3 mRNA	15693093
D015741	Metribolone	Metribolone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
C100075	mibolerone	mibolerone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
D015735	Mifepristone	Mifepristone results in increased expression of MMP3 mRNA	17584828
D015735	Mifepristone	Mifepristone results in increased expression of MMP3 mRNA	19439560
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of MMP3 mRNA]	27264040
D008911	Minocycline	Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP3 mRNA]	19285099
C523799	MRK 003	MMP3 results in decreased susceptibility to MRK 003	19903844
C500085	muraglitazar	muraglitazar results in decreased expression of MMP3 mRNA	21515302
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of MMP3 mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of MMP3 mRNA	25554681
D009532	Nickel	Nickel results in increased expression of MMP3 mRNA	25583101
D009532	Nickel	TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]	23503329
D009532	Nickel	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA	23503329
C029938	nickel sulfate	nickel sulfate results in increased expression of MMP3 mRNA	16780908
C029938	nickel sulfate	nickel sulfate results in increased expression of MMP3 mRNA	16166746
D009538	Nicotine	lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP3 mRNA]	18986645
D009538	Nicotine	Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA]	18986645
D009538	Nicotine	Nicotine results in increased expression of MMP3 mRNA	17151781; 18986645;
D009538	Nicotine	Nicotine results in increased expression of MMP3 protein	17151781
C012655	nimesulide	nimesulide results in decreased expression of MMP3 protein	12166616
C500716	N-isobutyl-N-(4-methoxyphenylsulfonyl)glycylhydroxamic acid	N-isobutyl-N-(4-methoxyphenylsulfonyl)glycylhydroxamic acid results in decreased activity of MMP3 protein	12972402
D009569	Nitric Oxide	Nitric Oxide results in increased expression of MMP3	24840287
D009569	Nitric Oxide	[NOC 18 results in increased abundance of Nitric Oxide] inhibits the reaction [Resveratrol inhibits the reaction [Nitric Oxide results in increased expression of MMP3]]	24840287
D009569	Nitric Oxide	Resveratrol inhibits the reaction [Nitric Oxide results in increased expression of MMP3]	24840287
D017672	Nitrogen Compounds	Nitrogen Compounds analog binds to and results in decreased activity of MMP3 protein	16522091
C093285	NOC 18	[NOC 18 results in increased abundance of Nitric Oxide] inhibits the reaction [Resveratrol inhibits the reaction [Nitric Oxide results in increased expression of MMP3]]	24840287
C487513	NSC 23766	NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA]	28710503
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of MMP3 mRNA	20971185
C118580	octylmethoxycinnamate	[enzacamene co-treated with octylmethoxycinnamate co-treated with bisphenol A co-treated with butylparaben] results in increased expression of MMP3 mRNA	25305543
D015242	Ofloxacin	Ofloxacin results in increased expression of MMP3 mRNA	21903125; 23067722;
D015242	Ofloxacin	Ofloxacin results in increased expression of MMP3 mRNA	20688128
D010100	Oxygen	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of MMP3 mRNA	30529165
D010100	Oxygen	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP3	24840287
D010100	Oxygen	Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP3]	24840287
D010126	Ozone	Ozone results in increased expression of MMP3 mRNA	20980218
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in increased expression of MMP3 mRNA	20705681
D017239	Paclitaxel	Paclitaxel results in increased expression of MMP3	18754875
D017239	Paclitaxel	Paclitaxel results in increased expression of MMP3 mRNA	18754875
D000073878	Palm Oil	Palm Oil results in decreased expression of MMP3 mRNA	18042831
D010269	Paraquat	Paraquat affects the expression of MMP3 mRNA	26345256
D010269	Paraquat	Paraquat results in increased expression of MMP3 mRNA	17215068; 26108578;
D010269	Paraquat	Paraquat results in increased expression of MMP3 protein	26988026
D052638	Particulate Matter	Particulate Matter results in decreased expression of MMP3 mRNA	31520698
D052638	Particulate Matter	Particulate Matter results in increased expression of MMP3 protein	30716388
C497431	PD-0200347	PD-0200347 results in decreased expression of MMP3 protein	15693013
C509204	PD168393	PD168393 inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]	29535049
D010455	Peptides	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	20004183
D010455	Peptides	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D010634	Phenobarbital	Phenobarbital affects the expression of MMP3 mRNA	19159669
D010672	Phenytoin	Phenytoin results in decreased expression of MMP3 mRNA	15948689
D064801	Phospholipase A2 Inhibitors	Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	19765281
D064801	Phospholipase A2 Inhibitors	Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	19765281
D064801	Phospholipase A2 Inhibitors	Phospholipase A2 Inhibitors results in decreased expression of MMP3 mRNA	19765281
C030614	picolinic acid	picolinic acid binds to and results in decreased activity of MMP3 protein	16522091
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MMP3 mRNA	19710929
D010938	Plant Oils	Plant Oils results in increased expression of MMP3 mRNA	23370395
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of MMP3 mRNA	21334430
C113831	poly-N-acetyl glucosamine	poly-N-acetyl glucosamine results in increased expression of MMP3 mRNA	19638916
D017035	Pravastatin	MMP3 promoter polymorphism affects the susceptibility to Pravastatin	8662692
C113282	prinomastat	prinomastat results in decreased activity of MMP3 protein	17267227
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased secretion of MMP3 protein	16009159
D011374	Progesterone	[Estrogens co-treated with Progesterone co-treated with IL1B protein] results in increased expression of MMP3 mRNA	18570937
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of MMP3 mRNA	17404688
D011374	Progesterone	Progesterone inhibits the reaction [IL1B protein results in increased expression of MMP3 protein modified form]	22219637
D011374	Progesterone	Progesterone results in decreased expression of MMP3 mRNA	26604029
D011374	Progesterone	Progesterone results in decreased secretion of MMP3 protein	16009159
D011374	Progesterone	Tetrachlorodibenzodioxin inhibits the reaction [Progesterone results in decreased secretion of MMP3 protein]	16009159
D011374	Progesterone	Triclosan inhibits the reaction [Progesterone results in decreased expression of MMP3 mRNA]	26604029
D011374	Progesterone	Progesterone affects the expression of MMP3 protein	17118170
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of MMP3 mRNA]	27264040
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased expression of MMP3 mRNA]	19416213
D011374	Progesterone	Progesterone results in decreased expression of MMP3 mRNA	27264040
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]	16778083
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Citrinin results in increased expression of MMP3 mRNA]	19361540
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP3 mRNA]	12832416
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
C014175	pyrazolo(3,4-d)pyrimidine	pyrazolo(3,4-d)pyrimidine analog affects the expression of MMP3 mRNA	21152443
D011725	Pyridines	Pyridines analog binds to and results in decreased activity of MMP3 protein	15237990
D011728	Pyridones	Pyridones analog binds to and results in decreased activity of MMP3 protein	15237990
D011753	Pyrones	Pyrones analog binds to and results in decreased activity of MMP3 protein	15237990
D011794	Quercetin	Quercetin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	22592909
D011794	Quercetin	Quercetin inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	22592909
D011794	Quercetin	Quercetin results in decreased expression of MMP3 mRNA	22592909
D011794	Quercetin	Quercetin results in decreased expression of MMP3 protein	22592909
D011794	Quercetin	Quercetin results in increased expression of MMP3 mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of MMP3 mRNA	17582780
C031389	resorcinol	resorcinol results in increased expression of MMP3 mRNA	30806763
D000077185	Resveratrol	Resveratrol inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	18759268
D000077185	Resveratrol	Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	23257246
D000077185	Resveratrol	[Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	20426787
D000077185	Resveratrol	[Hyaluronic Acid co-treated with Resveratrol] results in decreased expression of MMP3 mRNA	23595953
D000077185	Resveratrol	[NOC 18 results in increased abundance of Nitric Oxide] inhibits the reaction [Resveratrol inhibits the reaction [Nitric Oxide results in increased expression of MMP3]]	24840287
D000077185	Resveratrol	Resveratrol affects the expression of MMP3	24066520
D000077185	Resveratrol	[Resveratrol co-treated with Curcumin] inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	19889203
D000077185	Resveratrol	Resveratrol inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	18606398
D000077185	Resveratrol	Resveratrol inhibits the reaction [Nitric Oxide results in increased expression of MMP3]	24840287
D000077185	Resveratrol	Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP3]	24840287
D000077185	Resveratrol	Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	23328930
D000077185	Resveratrol	Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP3 protein]	23328930
D000077185	Resveratrol	Resveratrol inhibits the reaction [TNF protein results in increased secretion of MMP3 protein]	23328930
C116926	rofecoxib	rofecoxib results in increased expression of MMP3 mRNA	16580899
D000077154	Rosiglitazone	Rosiglitazone results in decreased expression of MMP3 mRNA	21515302
C410958	sauchinone	sauchinone inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	29356224
C093642	SB 203580	SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
C015499	schizandrin B	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP3 mRNA]	31150632
C078903	seocalcitol	seocalcitol results in increased expression of MMP3 mRNA	12040012
C421267	SI 27	SI 27 inhibits the reaction [Isoproterenol results in increased expression of MMP3]	12883319
D012834	Silver	Silver results in increased expression of MMP3 mRNA	24022940
D012834	Silver	Silver results in increased expression of MMP3 mRNA	19969064
D019821	Simvastatin	Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	31260663
D019821	Simvastatin	Simvastatin results in decreased expression of MMP3	19801495
D019821	Simvastatin	Simvastatin results in decreased expression of MMP3 mRNA	16414398
C017947	sodium arsenite	sodium arsenite results in decreased expression of MMP3 mRNA	29301061
D019810	Sodium Azide	Sodium Azide inhibits the reaction [Aminolevulinic Acid affects the expression of MMP3 protein]	12542540
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of MMP3 mRNA	30806763
D012980	Sodium Salicylate	Sodium Salicylate inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	10336562
D012999	Soman	Soman results in increased expression of MMP3 mRNA	19281266
D053260	Soot	Soot results in increased expression of MMP3 mRNA	22461453; 26551751;
D013311	Streptozocin	PRDX4 protein inhibits the reaction [Streptozocin results in increased expression of MMP3 mRNA]	20446767
D013311	Streptozocin	Streptozocin results in increased expression of MMP3 mRNA	20446767
D013311	Streptozocin	Streptozocin results in decreased expression of MMP3 mRNA	18246672
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of MMP3 protein]	16684522
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	16684522
D012460	Sulfasalazine	Sulfasalazine results in decreased expression of and results in decreased activity of MMP3 protein	16684522
D013605	T-2 Toxin	T-2 Toxin results in increased expression of MMP3 mRNA	22800716
D013629	Tamoxifen	Tamoxifen affects the expression of MMP3 mRNA	17555576
C501413	tesaglitazar	tesaglitazar results in decreased expression of MMP3 mRNA	21515302
D013739	Testosterone	Testosterone results in decreased expression of MMP3 mRNA	19693291
D013739	Testosterone	Testosterone results in increased expression of MMP3 mRNA	19693291
D013749	Tetrachlorodibenzodioxin	13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP3 mRNA]	20865247
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Progesterone results in decreased secretion of MMP3 protein]	16009159
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MMP3 mRNA	20865247; 23152189;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MMP3 protein	15531779
D013749	Tetrachlorodibenzodioxin	zerumbone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP3 mRNA]	20865247
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MMP3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MMP3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MMP3 mRNA	21354282
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of MMP3 mRNA	16010555
D013752	Tetracycline	Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	17267227
D013752	Tetracycline	Tetracycline results in decreased activity of MMP3 protein	17267227
D013752	Tetracycline	Tetracycline results in decreased expression of MMP3 mRNA	24489787
D013755	Tetradecanoylphorbol Acetate	BAG1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	20858459
D013755	Tetradecanoylphorbol Acetate	Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	20858459
D013755	Tetradecanoylphorbol Acetate	Dihydrotestosterone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
D013755	Tetradecanoylphorbol Acetate	Metribolone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
D013755	Tetradecanoylphorbol Acetate	mibolerone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
D013755	Tetradecanoylphorbol Acetate	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	20004183
D013755	Tetradecanoylphorbol Acetate	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D013755	Tetradecanoylphorbol Acetate	pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D013755	Tetradecanoylphorbol Acetate	SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA	16176868; 20004183; 20858459; 8798622;
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein	20004183
D013755	Tetradecanoylphorbol Acetate	Tretinoin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	16176868
D013755	Tetradecanoylphorbol Acetate	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MMP3 mRNA	25613284
D013853	Thioacetamide	CNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of MMP3 mRNA]	21863215
D013853	Thioacetamide	[Ethanol co-treated with Thioacetamide] results in increased expression of MMP3 mRNA	21863215
D013853	Thioacetamide	halofuginone promotes the reaction [Thioacetamide results in increased expression of MMP3 mRNA]	16489207
D013853	Thioacetamide	Thioacetamide results in increased expression of MMP3 mRNA	16489207
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	24975507
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	24975507
C009495	titanium dioxide	titanium dioxide results in increased expression of MMP3 mRNA	23557971; 27760801;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of MMP3 mRNA	27865774; 29501877;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MMP3 mRNA	10836612; 27404394; 29505817; 30610935;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MMP3 protein	27480279; 30291989;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MMP3 mRNA	23967268
C024746	tobacco tar	tobacco tar results in increased expression of MMP3 mRNA	19559774
C479163	tofacitinib	tofacitinib results in decreased expression of MMP3 mRNA	25398374
C513941	tongxinluo	tongxinluo results in decreased expression of MMP3	19801495
D014118	Toxins, Biological	Toxins, Biological affects the expression of MMP3 mRNA	19682533
D014212	Tretinoin	Tretinoin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	16176868
D014212	Tretinoin	Tretinoin results in increased expression of MMP3 mRNA	16249480
D014260	Triclosan	Triclosan inhibits the reaction [Progesterone results in decreased expression of MMP3 mRNA]	26604029
D014260	Triclosan	Triclosan results in increased expression of MMP3 mRNA	26604029
D017973	Tungsten Compounds	Tungsten Compounds results in increased expression of MMP3 mRNA	28666766
C113580	U 0126	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D014638	Vanadates	Vanadates results in increased expression of MMP3 mRNA	22714537
C545088	varespladib methyl	varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	19765281
C545088	varespladib methyl	varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	19765281
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of MMP3 mRNA	17065432
C403304	zerumbone	zerumbone inhibits the reaction [DDT results in increased expression of MMP3 mRNA]	20865247
C403304	zerumbone	zerumbone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP3 mRNA]	20865247
D015032	Zinc	Zinc results in increased secretion of MMP3 protein	12972402
D015032	Zinc	TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]	23503329
D015032	Zinc	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA	23503329
D015054	Zymosan	NCF1 protein affects the reaction [Zymosan results in increased expression of MMP3 mRNA]	14507659
D015054	Zymosan	Zymosan results in increased expression of MMP3 mRNA	14507659

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0106	Calcium
KW-0177	Collagen degradation
KW-0903	Direct protein sequencing
KW-1015	Disulfide bond
KW-0272	Extracellular matrix
KW-0378	Hydrolase
KW-0479	Metal-binding
KW-0482	Metalloprotease
KW-0621	Polymorphism
KW-0645	Protease
KW-1185	Reference proteome
KW-0677	Repeat
KW-0964	Secreted
KW-0732	Signal
KW-0862	Zinc
KW-0865	Zymogen

Interpro

InterPro ID	InterPro Term
IPR000585	Hemopexin-like_dom
IPR036375	Hemopexin-like_dom_sf
IPR018487	Hemopexin-like_repeat
IPR018486	Hemopexin_CS
IPR033739	M10A_MMP
IPR024079	MetalloPept_cat_dom_sf
IPR001818	Pept_M10_metallopeptidase
IPR021190	Pept_M10A
IPR021158	Pept_M10A_Zn_BS
IPR006026	Peptidase_Metallo
IPR002477	Peptidoglycan-bd-like
IPR036365	PGBD-like_sf

PROSITE

PROSITE ID	PROSITE Term
PS00546	CYSTEINE_SWITCH
PS00024	HEMOPEXIN
PS51642	HEMOPEXIN_2
PS00142	ZINC_PROTEASE

Pfam

Pfam ID	Pfam Term
PF00045	Hemopexin
PF00413	Peptidase_M10
PF01471	PG_binding_1

Gene: MMP3

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Identified variants/mutations related to cleft phenotype

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction