Gene: Hoxa1

Basic information

Tag Content
Uniprot ID P09022; P15463;
Entrez ID
Genbank protein ID AAA37839.1; CAA29426.1; AAA37559.1; AAA37558.1; CAA29427.1;
Genbank nucleotide ID
Ensembl protein ID
Ensembl nucleotide ID
Gene name Homeobox protein Hox-A1
Gene symbol Hoxa1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 10529419; 7903601;
Functional description Sequence-specific transcription factor (PubMed:29465778). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (By similarity). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (PubMed:29465778).
Sequence
MNSFLEYPIL GSGDSGTCSA RAYPSDHGIT TFQSCAVSAN SCGGDDRFLV GRGVQISSPH 60
HHHHHHHHHH PQTATYQTSG NLGISYSHSS CGPSYGAQNF SAPYGPYGLN QEADVSGGYP 120
PCAPAVYSGN LSTPMVQHHH HHQGYAGGTV GSPQYIHHSY GQEQQTLALA TYNNSLSPLH 180
ASHQEACRSP ASETSSPAQT FDWMKVKRNP PKTGKVGEYG YVGQPNAVRT NFTTKQLTEL 240
EKEFHFNKYL TRARRVEIAA SLQLNETQVK IWFQNRRMKQ KKREKEGLLP ISPATPPGSD 300
EKTEESSEKS SPSPSAPSPA SSTSDTLTTS H 331

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI
GO:0042802 identical protein bindingISO
GO:0043565 sequence-specific DNA bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0006357 regulation of transcription by RNA polymerase IIIDA
GO:0007399 nervous system developmentIMP
GO:0007605 sensory perception of soundISO
GO:0007634 optokinetic behaviorISO
GO:0008045 motor neuron axon guidanceIGI
GO:0009653 anatomical structure morphogenesisISO
GO:0009653 anatomical structure morphogenesisIGI
GO:0009952 anterior/posterior pattern specificationIGI
GO:0009952 anterior/posterior pattern specificationIMP
GO:0021569 rhombomere 3 developmentIGI
GO:0021569 rhombomere 3 developmentIMP
GO:0021570 rhombomere 4 developmentIGI
GO:0021570 rhombomere 4 developmentIMP
GO:0021571 rhombomere 5 developmentIGI
GO:0021571 rhombomere 5 developmentIMP
GO:0021599 abducens nerve formationISO
GO:0021612 facial nerve structural organizationIGI
GO:0021754 facial nucleus developmentIMP
GO:0021953 central nervous system neuron differentiationIMP
GO:0030902 hindbrain developmentIMP
GO:0042472 inner ear morphogenesisIMP
GO:0042473 outer ear morphogenesisISO
GO:0045944 positive regulation of transcription by RNA polymerase IIISO
GO:0045944 positive regulation of transcription by RNA polymerase IIIDA
GO:0048646 anatomical structure formation involved in morphogenesisIGI
GO:0048702 embryonic neurocranium morphogenesisISO
GO:0048839 inner ear developmentISO
GO:0048844 artery morphogenesisISO
GO:0050795 regulation of behaviorISO
GO:0050890 cognitionISO
GO:0050905 neuromuscular processISO
GO:0060840 artery developmentISO
GO:0060876 semicircular canal formationISO
GO:0071300 cellular response to retinoic acidIDA
GO:0071361 cellular response to ethanolIEP
GO:0090102 cochlea developmentISO
GO:0090103 cochlea morphogenesisISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005654 nucleoplasmTAS

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0217 Developmental protein
KW-0903 Direct protein sequencing
KW-0238 DNA-binding
KW-0325 Glycoprotein
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain

Protein-protein interaction

Protein-miRNA interaction