Gene: GSTP1

Basic information

Tag Content
Uniprot ID P09211; O00460; Q15690; Q5TZY3;
Entrez ID 2950
Genbank protein ID AAC51237.1; AAV38753.1; AAA56823.1; AAV38752.1; CAA33508.1; CAG29357.1; AAP72967.1; CAA30894.1; CAA29794.1; CAA30847.1; AAA64919.1; AAC51280.1; AAC13869.1; AAH10915.1;
Genbank nucleotide ID NM_000852.3
Ensembl protein ID ENSP00000381607
Ensembl nucleotide ID ENSG00000084207
Gene name Glutathione S-transferase P
Gene symbol GSTP1
Organism Homo sapiens
NCBI taxa ID 9606
Cleft type CPO,CL/P
Developmental stage
Data sources Manually collected
Reference 18159215
Functional description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Sequence
MPPYTVVYFP VRGRCAALRM LLADQGQSWK EEVVTVETWQ EGSLKASCLY GQLPKFQDGD 60
LTLYQSNTIL RHLGRTLGLY GKDQQEAALV DMVNDGVEDL RCKYISLIYT NYEAGKDDYV 120
KALPGQLKPF ETLLSQNQGG KTFIVGDQIS FADYNLLDLL LIHEVLAPGC LDAFPLLSAY 180
VGRLSARPKL KAFLASPEYV NLPINGNGKQ

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
GSTP1I105VTDT18159215

Other genetic variants/mutations

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Disease or phenotype associated information

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0004364 glutathione transferase activityIDA
GO:0004364 glutathione transferase activityIBA
GO:0004602 glutathione peroxidase activityIDA
GO:0005515 protein bindingIPI
GO:0008144 drug bindingIEA
GO:0008432 JUN kinase bindingISS
GO:0019207 kinase regulator activityISS
GO:0035730 S-nitrosoglutathione bindingIDA
GO:0035731 dinitrosyl-iron complex bindingIDA
GO:0043295 glutathione bindingIEA
GO:0070026 nitric oxide bindingNAS

GO:Biological Process

GO ID GO Term Evidence
GO:0000302 response to reactive oxygen speciesISS
GO:0002674 negative regulation of acute inflammatory responseNAS
GO:0006469 negative regulation of protein kinase activityIDA
GO:0006749 glutathione metabolic processIDA
GO:0006749 glutathione metabolic processIBA
GO:0006805 xenobiotic metabolic processIDA
GO:0007417 central nervous system developmentTAS
GO:0009890 negative regulation of biosynthetic processIDA
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathwayIC
GO:0014003 oligodendrocyte developmentIEA
GO:0031100 animal organ regenerationIEA
GO:0032355 response to estradiolIEA
GO:0032691 negative regulation of interleukin-1 beta productionIDA
GO:0032720 negative regulation of tumor necrosis factor productionIDA
GO:0032869 cellular response to insulin stimulusIEA
GO:0032872 regulation of stress-activated MAPK cascadeISS
GO:0032873 negative regulation of stress-activated MAPK cascadeISS
GO:0032930 positive regulation of superoxide anion generationISS
GO:0033591 response to L-ascorbic acidIEA
GO:0034599 cellular response to oxidative stressTAS
GO:0035726 common myeloid progenitor cell proliferationISS
GO:0035732 nitric oxide storageNAS
GO:0043066 negative regulation of apoptotic processTAS
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signalingISS
GO:0043200 response to amino acidIEA
GO:0043312 neutrophil degranulationTAS
GO:0043407 negative regulation of MAP kinase activityIDA
GO:0043409 negative regulation of MAPK cascadeNAS
GO:0043508 negative regulation of JUN kinase activityIDA
GO:0043651 linoleic acid metabolic processIDA
GO:0045471 response to ethanolIEA
GO:0048147 negative regulation of fibroblast proliferationISS
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic processIDA
GO:0070372 regulation of ERK1 and ERK2 cascadeISS
GO:0070373 negative regulation of ERK1 and ERK2 cascadeIDA
GO:0070664 negative regulation of leukocyte proliferationISS
GO:0071222 cellular response to lipopolysaccharideISS
GO:0071364 cellular response to epidermal growth factor stimulusIEA
GO:0071385 cellular response to glucocorticoid stimulusIEA
GO:0071460 cellular response to cell-matrix adhesionIEA
GO:0071638 negative regulation of monocyte chemotactic protein-1 productionIDA
GO:0071672 negative regulation of smooth muscle cell chemotaxisIEA
GO:0098869 cellular oxidant detoxificationIEA
GO:1901687 glutathione derivative biosynthetic processTAS
GO:1904706 negative regulation of vascular smooth muscle cell proliferationIEA
GO:2001237 negative regulation of extrinsic apoptotic signaling pathwayIDA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005576 extracellular regionTAS
GO:0005615 extracellular spaceHDA
GO:0005634 nucleusIEA
GO:0005737 cytoplasmTAS
GO:0005739 mitochondrionIDA
GO:0005829 cytosolIDA
GO:0005829 cytosolIBA
GO:0005829 cytosolTAS
GO:0005886 plasma membraneIEA
GO:0031982 vesicleHDA
GO:0034774 secretory granule lumenTAS
GO:0070062 extracellular exosomeHDA
GO:0097057 TRAF2-GSTP1 complexIDA
GO:1904813 ficolin-1-rich granule lumenTAS

Reactome Pathway

Reactome ID Reactome Term Evidence
R-HSA-1430728 MetabolismTAS
R-HSA-156580 Phase II - Conjugation of compoundsTAS
R-HSA-156590 Glutathione conjugationTAS
R-HSA-168249 Innate Immune SystemTAS
R-HSA-168256 Immune SystemTAS
R-HSA-211859 Biological oxidationsTAS
R-HSA-2262752 Cellular responses to stressTAS
R-HSA-3299685 Detoxification of Reactive Oxygen SpeciesTAS
R-HSA-6798695 Neutrophil degranulationTAS
R-HSA-8953897 Cellular responses to external stimuliTAS

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0007 Acetylation
KW-0963 Cytoplasm
KW-0903 Direct protein sequencing
KW-0496 Mitochondrion
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-0621 Polymorphism
KW-1185 Reference proteome
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003082 GST_pi
IPR036249 Thioredoxin-like_sf

PROSITE

PROSITE ID PROSITE Term
PS50405 GST_CTER
PS50404 GST_NTER

Pfam

Pfam ID Pfam Term
PF14497 GST_C_3
PF02798 GST_N

Protein-protein interaction

Protein-miRNA interaction