CleftGeneDB-Search

Gene: TPM1

Basic information

Tag	Content
Uniprot ID	P09493; B7Z5T7; D9YZV2; D9YZV3; D9YZV8; P09494; P10469; Q6DV89; Q6DV90; Q7Z6L8; Q86W64; Q96IK2; Q9UCI1; Q9UCI2; Q9UCY9; Q9Y427;
Entrez ID	7168
Genbank protein ID	AAT68295.1; AAH07433.1; EAW77627.1; BAH13023.1; EAW77622.1; ADL14506.1; AAA36771.1; AAA61226.1; EAW77623.1; ADL14500.1; EAW77619.1; ADL14504.1; AAH53545.1; ADL14501.1; EAW77628.1; AAA61225.1; AAT68294.1; AAH50473.1; CAB43309.2; CAA30930.1; AAA61227.1;
Genbank nucleotide ID	NM_001018004.1; NM_001330351.1; NM_001330344.1; XM_017022538.1; NM_000366.5; NM_001018008.1; NM_001018020.1; NM_001330346.1; NM_001018005.1; NM_001018007.1; NM_001018006.1; NM_001301244.1;
Ensembl protein ID	ENSP00000453941; ENSP00000267996; ENSP00000351022; ENSP00000288398; ENSP00000385107; ENSP00000334624; ENSP00000452879; ENSP00000453955;
Ensembl nucleotide ID	ENSG00000140416
Gene name	Tropomyosin alpha-1 chain
Gene symbol	TPM1
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type	CPO,CL/P
Developmental stage
Data sources	Manually collected
Reference	26792422
Functional description	Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Sequence	MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY 60 SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 120 DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE 180 ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE 240 FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI 284

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
3MUD
5KHT

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
TPM1	rs1972041G>A	Genotyping	26792422
TPM1	rs11071720 (Homozygous and recessive; increase risk)	PCR	30888054
TPM1	rs12148828 (codominant; protective)	PCR	30888054
TPM1	rs3803499 (recessive and codominant; increase risk)	PCR	30888054

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
RCV000036324	p.Met1Ter	frameshift	-	NC_000015.10:g.63042831del	ClinVar
rs1060501865	p.Asp2His	missense variant	-	NC_000015.10:g.63042833G>C	-
RCV000457778	p.Asp2His	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63042833G>C	ClinVar
rs730881148	p.Ile4Val	missense variant	-	NC_000015.10:g.63042839A>G	-
RCV000159393	p.Ile4Val	missense variant	-	NC_000015.10:g.63042839A>G	ClinVar
NCI-TCGA novel	p.Lys5Arg	missense variant	-	NC_000015.10:g.63042843A>G	NCI-TCGA
rs397516364	p.Met8Arg	missense variant	-	NC_000015.10:g.63042852T>G	-
RCV000036318	p.Met8Arg	missense variant	Primary dilated cardiomyopathy (DCM)	NC_000015.10:g.63042852T>G	ClinVar
RCV000521387	p.Gln9Leu	missense variant	-	NC_000015.10:g.63042855A>T	ClinVar
RCV000619514	p.Gln9Lys	missense variant	-	NC_000015.10:g.63042854C>A	ClinVar
rs1555402931	p.Gln9Leu	missense variant	-	NC_000015.10:g.63042855A>T	-
RCV000159394	p.Gln9Lys	missense variant	-	NC_000015.10:g.63042854C>A	ClinVar
rs730881149	p.Gln9Lys	missense variant	-	NC_000015.10:g.63042854C>A	-
NCI-TCGA novel	p.Leu13Phe	missense variant	-	NC_000015.10:g.63042866C>T	NCI-TCGA
rs876661210	p.Asp14Tyr	missense variant	-	NC_000015.10:g.63042869G>T	-
RCV000213187	p.Asp14Tyr	missense variant	-	NC_000015.10:g.63042869G>T	ClinVar
rs199476301	p.Lys15Asn	missense variant	-	NC_000015.10:g.63042874G>T	ExAC,gnomAD
rs869025539	p.Lys15Arg	missense variant	-	NC_000015.10:g.63042873A>G	-
RCV000024588	p.Lys15Asn	missense variant	-	NC_000015.10:g.63042874G>T	ClinVar
RCV000208520	p.Lys15Arg	missense variant	Left ventricular noncompaction cardiomyopathy	NC_000015.10:g.63042873A>G	ClinVar
RCV000159395	p.Glu16Gln	missense variant	-	NC_000015.10:g.63042875G>C	ClinVar
rs727504290	p.Glu16Gln	missense variant	-	NC_000015.10:g.63042875G>C	-
RCV000154303	p.Glu16Gln	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63042875G>C	ClinVar
rs878854150	p.Asn17Lys	missense variant	-	NC_000015.10:g.63042880C>G	TOPMed,gnomAD
rs878854150	p.Asn17Lys	missense variant	-	NC_000015.10:g.63042880C>A	TOPMed,gnomAD
RCV000227176	p.Asn17Lys	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63042880C>G	ClinVar
rs727504391	p.Asp20Asn	missense variant	-	NC_000015.10:g.63042887G>A	-
RCV000766942	p.Asp20Asn	missense variant	-	NC_000015.10:g.63042887G>A	ClinVar
RCV000154553	p.Asp20Asn	missense variant	-	NC_000015.10:g.63042887G>A	ClinVar
rs730881151	p.Arg21Leu	missense variant	-	NC_000015.10:g.63042891G>T	ExAC,TOPMed,gnomAD
RCV000201492	p.Arg21Leu	missense variant	Familial hypertrophic cardiomyopathy 3 (CMH3)	NC_000015.10:g.63042891G>T	ClinVar
RCV000036351	p.Ala22Thr	missense variant	-	NC_000015.10:g.63042893G>A	ClinVar
rs397516382	p.Ala22Thr	missense variant	-	NC_000015.10:g.63042893G>A	1000Genomes,ExAC,TOPMed,gnomAD
RCV000618601	p.Ala22Thr	missense variant	-	NC_000015.10:g.63042893G>A	ClinVar
RCV000223842	p.Ala22Thr	missense variant	-	NC_000015.10:g.63042893G>A	ClinVar
rs876661396	p.Glu23Asp	missense variant	-	NC_000015.10:g.63042898G>C	-
rs199476302	p.Glu23Gln	missense variant	-	NC_000015.10:g.63042896G>C	-
RCV000223855	p.Glu23Asp	missense variant	-	NC_000015.10:g.63042898G>C	ClinVar
RCV000024589	p.Glu23Gln	missense variant	-	NC_000015.10:g.63042896G>C	ClinVar
RCV000157543	p.Glu26Gly	missense variant	Primary familial hypertrophic cardiomyopathy (HCM)	NC_000015.10:g.63042906A>G	ClinVar
rs730880234	p.Glu26Gly	missense variant	-	NC_000015.10:g.63042906A>G	-
rs1346512134	p.Ala27Val	missense variant	-	NC_000015.10:g.63042909C>T	gnomAD
rs397516391	p.Asp28Asn	missense variant	-	NC_000015.10:g.63042911G>A	TOPMed,gnomAD
RCV000766945	p.Asp28His	missense variant	-	NC_000015.10:g.63042911G>C	ClinVar
RCV000621745	p.Asp28Asn	missense variant	-	NC_000015.10:g.63042911G>A	ClinVar
RCV000036363	p.Asp28Asn	missense variant	-	NC_000015.10:g.63042911G>A	ClinVar
rs397516391	p.Asp28His	missense variant	-	NC_000015.10:g.63042911G>C	TOPMed,gnomAD
rs397516391	p.Asp28Tyr	missense variant	-	NC_000015.10:g.63042911G>T	TOPMed,gnomAD
RCV000769476	p.Asp28Asn	missense variant	Cardiomyopathy (CMYO)	NC_000015.10:g.63042911G>A	ClinVar
RCV000766946	p.Asp28Asn	missense variant	-	NC_000015.10:g.63042911G>A	ClinVar
RCV000768533	p.Asp28Asn	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63042911G>A	ClinVar
rs1255071660	p.Lys29Glu	missense variant	-	NC_000015.10:g.63042914A>G	gnomAD
rs1447267149	p.Lys30Arg	missense variant	-	NC_000015.10:g.63042918A>G	gnomAD
rs1555402999	p.Lys30Ala	missense variant	-	NC_000015.10:g.63042917_63042918delinsGC	-
RCV000531857	p.Lys30Ala	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63042917_63042918delinsGC	ClinVar
RCV000036370	p.Ala31Thr	missense variant	-	NC_000015.10:g.63042920G>A	ClinVar
rs749500508	p.Ala31Glu	missense variant	-	NC_000015.10:g.63042921C>A	ExAC,gnomAD
rs397516396	p.Ala31Thr	missense variant	-	NC_000015.10:g.63042920G>A	-
RCV000543459	p.Glu33Ala	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63042927A>C	ClinVar
RCV000036371	p.Glu33Lys	missense variant	-	NC_000015.10:g.63042926G>A	ClinVar
rs397516397	p.Glu33Lys	missense variant	-	NC_000015.10:g.63042926G>A	-
COSM4937699	p.Glu33Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000015.10:g.63042927A>G	NCI-TCGA Cosmic
rs1448738061	p.Arg35Ser	missense variant	-	NC_000015.10:g.63042934G>C	gnomAD
rs730881152	p.Arg35Lys	missense variant	-	NC_000015.10:g.63042933G>A	TOPMed
RCV000776457	p.Arg35Lys	missense variant	Cardiomyopathy (CMYO)	NC_000015.10:g.63042933G>A	ClinVar
rs730881152	p.Arg35Thr	missense variant	-	NC_000015.10:g.63042933G>C	TOPMed
RCV000159402	p.Arg35Thr	missense variant	-	NC_000015.10:g.63042933G>C	ClinVar
RCV000769477	p.Ser36Gly	missense variant	Cardiomyopathy (CMYO)	NC_000015.10:g.63042935A>G	ClinVar
rs1174194983	p.Ser36Asn	missense variant	-	NC_000015.10:g.63042936G>A	gnomAD
RCV000024593	p.Lys37Glu	missense variant	-	NC_000015.10:g.63042938A>G	ClinVar
rs199476303	p.Lys37Glu	missense variant	-	NC_000015.10:g.63042938A>G	-
RCV000462958	p.Gln38Glu	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63042941C>G	ClinVar
rs1060501863	p.Gln38Glu	missense variant	-	NC_000015.10:g.63042941C>G	-
rs104894501	p.Glu40Gln	missense variant	-	NC_000015.10:g.63044030G>C	TOPMed,gnomAD
RCV000766947	p.Glu40Ter	nonsense	-	NC_000015.10:g.63044030G>T	ClinVar
RCV000700155	p.Glu40Ter	nonsense	Hypertrophic cardiomyopathy	NC_000015.10:g.63044030G>T	ClinVar
rs104894501	p.Glu40Lys	missense variant	-	NC_000015.10:g.63044030G>A	TOPMed,gnomAD
rs104894501	p.Glu40Ter	stop gained	-	NC_000015.10:g.63044030G>T	TOPMed,gnomAD
rs104894501	p.Glu40Lys	missense variant	Cardiomyopathy, dilated 1Y (CMD1Y)	NC_000015.10:g.63044030G>A	UniProt,dbSNP
VAR_043986	p.Glu40Lys	missense variant	Cardiomyopathy, dilated 1Y (CMD1Y)	NC_000015.10:g.63044030G>A	UniProt
RCV000036315	p.Glu40Ter	nonsense	-	NC_000015.10:g.63044030G>T	ClinVar
RCV000013275	p.Glu40Lys	missense variant	Dilated cardiomyopathy 1Y (CMD1Y)	NC_000015.10:g.63044030G>A	ClinVar
RCV000621859	p.Glu40Ter	nonsense	-	NC_000015.10:g.63044030G>T	ClinVar
RCV000488962	p.Glu40Gln	missense variant	-	NC_000015.10:g.63044030G>C	ClinVar
rs1406954948	p.Val44Leu	missense variant	-	NC_000015.10:g.63044042G>T	gnomAD
NCI-TCGA novel	p.Ser45Leu	missense variant	-	NC_000015.10:g.63044046C>T	NCI-TCGA
rs1060501864	p.Gln47Arg	missense variant	-	NC_000015.10:g.63044052A>G	-
RCV000469579	p.Gln47Arg	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63044052A>G	ClinVar
NCI-TCGA novel	p.Lys48Glu	missense variant	-	NC_000015.10:g.63044054A>G	NCI-TCGA
rs1060501866	p.Leu50Phe	missense variant	-	NC_000015.10:g.63044060C>T	-
rs1060501866	p.Leu50Ile	missense variant	-	NC_000015.10:g.63044060C>A	-
RCV000530381	p.Leu50Phe	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63044060C>T	ClinVar
RCV000464388	p.Leu50Ile	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63044060C>A	ClinVar
RCV000701909	p.Lys51Arg	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63044064A>G	ClinVar
rs757460987	p.Gly52Val	missense variant	-	NC_000015.10:g.63044067G>T	ExAC,gnomAD
rs730881127	p.Gly52Ser	missense variant	-	NC_000015.10:g.63044066G>A	-
RCV000159348	p.Gly52Ser	missense variant	-	NC_000015.10:g.63044066G>A	ClinVar
rs104894505	p.Glu54Lys	missense variant	Cardiomyopathy, dilated 1Y (CMD1Y)	NC_000015.10:g.63044072G>A	UniProt,dbSNP
VAR_043987	p.Glu54Lys	missense variant	Cardiomyopathy, dilated 1Y (CMD1Y)	NC_000015.10:g.63044072G>A	UniProt
rs104894505	p.Glu54Lys	missense variant	-	NC_000015.10:g.63044072G>A	-
RCV000159370	p.Glu54Lys	missense variant	-	NC_000015.10:g.63044072G>A	ClinVar
RCV000706303	p.Asp55Gly	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63044076A>G	ClinVar
NCI-TCGA novel	p.Asp55Glu	missense variant	-	NC_000015.10:g.63044077T>G	NCI-TCGA
rs397516363	p.Asp55Asn	missense variant	-	NC_000015.10:g.63044075G>A	-
RCV000036316	p.Asp55Asn	missense variant	Primary dilated cardiomyopathy (DCM)	NC_000015.10:g.63044075G>A	ClinVar
RCV000456653	p.Asp58His	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63044084G>C	ClinVar
COSM4923198	p.Tyr60Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000015.10:g.63044091A>G	NCI-TCGA Cosmic
COSM1478249	p.Ser61LeuPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000015.10:g.63044092C>-	NCI-TCGA Cosmic
RCV000768494	p.Glu62Gln	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63044096G>C	ClinVar
rs1064796782	p.Ala63Thr	missense variant	-	NC_000015.10:g.63044099G>A	-
rs199476306	p.Ala63Val	missense variant	Cardiomyopathy, familial hypertrophic 3 (CMH3)	NC_000015.10:g.63044100C>T	UniProt,dbSNP
VAR_013135	p.Ala63Val	missense variant	Cardiomyopathy, familial hypertrophic 3 (CMH3)	NC_000015.10:g.63044100C>T	UniProt
RCV000619544	p.Ala63Val	missense variant	-	NC_000015.10:g.63044100C>T	ClinVar
RCV000478328	p.Ala63Thr	missense variant	-	NC_000015.10:g.63044099G>A	ClinVar
NCI-TCGA novel	p.Asp66His	missense variant	-	NC_000015.10:g.63044108G>C	NCI-TCGA
COSM1587957	p.Ala67Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000015.10:g.63044112C>T	NCI-TCGA Cosmic
rs199476307	p.Lys70Thr	missense variant	-	NC_000015.10:g.63044121A>C	-
RCV000024574	p.Lys70Thr	missense variant	-	NC_000015.10:g.63044121A>C	ClinVar
RCV000159376	p.Leu71Val	missense variant	-	NC_000015.10:g.63044123C>G	ClinVar
rs730881143	p.Leu71Val	missense variant	-	NC_000015.10:g.63044123C>G	-
RCV000769479	p.Glu72Lys	missense variant	Cardiomyopathy (CMYO)	NC_000015.10:g.63044126G>A	ClinVar
NCI-TCGA novel	p.Glu72Ter	stop gained	-	NC_000015.10:g.63044126G>T	NCI-TCGA
rs1358909905	p.Glu72Gly	missense variant	-	NC_000015.10:g.63044127A>G	gnomAD
rs1555403432	p.Lys76Glu	missense variant	-	NC_000015.10:g.63044138A>G	-
RCV000560089	p.Lys76Glu	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63044138A>G	ClinVar
NCI-TCGA novel	p.Asp80Asn	missense variant	-	NC_000015.10:g.63044150G>A	NCI-TCGA
rs730881130	p.Ala83Asp	missense variant	-	NC_000015.10:g.63056992C>A	-
RCV000159355	p.Ala83Asp	missense variant	-	NC_000015.10:g.63056992C>A	ClinVar
RCV000036320	p.Asp84Glu	missense variant	-	NC_000015.10:g.63056996C>G	ClinVar
rs754664923	p.Asp84Asn	missense variant	-	NC_000015.10:g.63056994G>A	ExAC,gnomAD
rs369617788	p.Asp84Glu	missense variant	-	NC_000015.10:g.63056996C>G	ESP,ExAC,TOPMed,gnomAD
RCV000242724	p.Asp84Asn	missense variant	-	NC_000015.10:g.63056994G>A	ClinVar
rs730881156	p.Val85Leu	missense variant	-	NC_000015.10:g.63056997G>T	ExAC,gnomAD
RCV000786233	p.Val85Leu	missense variant	-	NC_000015.10:g.63056997G>T	ClinVar
RCV000544344	p.Val85Leu	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63056997G>T	ClinVar
RCV000534139	p.Val85Ile	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63056997G>A	ClinVar
rs730881156	p.Val85Ile	missense variant	-	NC_000015.10:g.63056997G>A	ExAC,gnomAD
rs757577112	p.Ala86Gly	missense variant	-	NC_000015.10:g.63057001C>G	ExAC,gnomAD
NCI-TCGA novel	p.Ala86Asp	missense variant	-	NC_000015.10:g.63057001C>A	NCI-TCGA
RCV000208058	p.Ala86Gly	missense variant	Primary dilated cardiomyopathy (DCM)	NC_000015.10:g.63057001C>G	ClinVar
NCI-TCGA novel	p.Ser87His	insertion	-	NC_000015.10:g.63057004_63057005insTCA	NCI-TCGA
NCI-TCGA novel	p.Ser87PhePheSerTerUnkUnk	frameshift	-	NC_000015.10:g.63057003_63057004insTTATTAAAATTAGGTTGGTTTTA	NCI-TCGA
RCV000560434	p.Leu88Val	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63057006C>G	ClinVar
rs1555407795	p.Leu88Val	missense variant	-	NC_000015.10:g.63057006C>G	-
RCV000489107	p.Asn89Lys	missense variant	-	NC_000015.10:g.63057011C>G	ClinVar
rs1085307487	p.Asn89Lys	missense variant	-	NC_000015.10:g.63057011C>G	-
rs1266444831	p.Arg91Cys	missense variant	-	NC_000015.10:g.63057015C>T	gnomAD
rs1477561695	p.Arg91His	missense variant	-	NC_000015.10:g.63057016G>A	TOPMed,gnomAD
rs730881157	p.Ile92Met	missense variant	-	NC_000015.10:g.63057020C>G	-
RCV000159408	p.Ile92Met	missense variant	-	NC_000015.10:g.63057020C>G	ClinVar
RCV000024587	p.Ile92Thr	missense variant	-	NC_000015.10:g.63057019T>C	ClinVar
rs746394586	p.Gln93Arg	missense variant	-	NC_000015.10:g.63057022A>G	ExAC,gnomAD
COSM3502945	p.Val95Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000015.10:g.63057028T>G	NCI-TCGA Cosmic
RCV000619092	p.Val95Ala	missense variant	-	NC_000015.10:g.63057028T>C	ClinVar
rs1064793284	p.Glu97Gln	missense variant	-	NC_000015.10:g.63057033G>C	-
RCV000482070	p.Glu97Gln	missense variant	-	NC_000015.10:g.63057033G>C	ClinVar
rs747907799	p.Arg101His	missense variant	-	NC_000015.10:g.63057046G>A	ExAC,gnomAD
rs769069020	p.Arg101Gly	missense variant	-	NC_000015.10:g.63057045C>G	ExAC,gnomAD
rs769069020	p.Arg101Cys	missense variant	-	NC_000015.10:g.63057045C>T	ExAC,gnomAD
rs397516367	p.Ala102Asp	missense variant	-	NC_000015.10:g.63057049C>A	-
RCV000036325	p.Ala102Asp	missense variant	-	NC_000015.10:g.63057049C>A	ClinVar
RCV000773445	p.Arg105His	missense variant	Cardiomyopathy (CMYO)	NC_000015.10:g.63057058G>A	ClinVar
rs773149185	p.Arg105His	missense variant	-	NC_000015.10:g.63057058G>A	ExAC,TOPMed,gnomAD
rs762922595	p.Thr108Ile	missense variant	-	NC_000015.10:g.63057067C>T	ExAC,gnomAD
RCV000736014	p.Leu113Val	missense variant	Left ventricular noncompaction 9 (LVNC9)	NC_000015.10:g.63057081C>G	ClinVar
rs397516370	p.Glu114Gly	missense variant	-	NC_000015.10:g.63057085A>G	-
RCV000036328	p.Glu114Gly	missense variant	Primary dilated cardiomyopathy (DCM)	NC_000015.10:g.63057085A>G	ClinVar
rs727504313	p.Glu115Lys	missense variant	-	NC_000015.10:g.63057087G>A	-
RCV000766948	p.Glu115Lys	missense variant	-	NC_000015.10:g.63057087G>A	ClinVar
RCV000154378	p.Glu115Lys	missense variant	-	NC_000015.10:g.63057087G>A	ClinVar
rs773916751	p.Lys118Asn	missense variant	-	NC_000015.10:g.63057098G>T	ExAC,gnomAD
COSM3502955	p.Lys118Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000015.10:g.63057096A>T	NCI-TCGA Cosmic
rs759173967	p.Ala119Thr	missense variant	-	NC_000015.10:g.63057099G>A	ExAC,gnomAD
rs876658031	p.Glu122Lys	missense variant	-	NC_000015.10:g.63057108G>A	-
RCV000217804	p.Glu122Lys	missense variant	-	NC_000015.10:g.63057108G>A	ClinVar
RCV000701011	p.Gly126Val	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63059565G>T	ClinVar
rs201211957	p.Met127Ile	missense variant	-	NC_000015.10:g.63059569G>A	-
RCV000172140	p.Met127Ile	missense variant	-	NC_000015.10:g.63059569G>A	ClinVar
RCV000491526	p.Ile130Val	missense variant	Pulmonary atresia with intact ventricular septum	NC_000015.10:g.63059576A>G	ClinVar
RCV000786231	p.Ile130Thr	missense variant	-	NC_000015.10:g.63059577T>C	ClinVar
RCV000619274	p.Ile130Thr	missense variant	-	NC_000015.10:g.63059577T>C	ClinVar
RCV000152117	p.Ile130Thr	missense variant	-	NC_000015.10:g.63059577T>C	ClinVar
RCV000549273	p.Ile130Thr	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63059577T>C	ClinVar
rs1114167355	p.Ile130Val	missense variant	-	NC_000015.10:g.63059576A>G	-
rs727503517	p.Ile130Thr	missense variant	-	NC_000015.10:g.63059577T>C	-
rs1005672618	p.Arg133Ter	stop gained	-	NC_000015.10:g.63059585C>T	gnomAD
rs11558749	p.Gln135Ter	stop gained	-	NC_000015.10:g.63059591C>T	gnomAD
rs11558749	p.Gln135Lys	missense variant	-	NC_000015.10:g.63059591C>A	gnomAD
RCV000024582	p.Gln135Lys	missense variant	-	NC_000015.10:g.63059591C>A	ClinVar
rs730881134	p.Asp137Gly	missense variant	-	NC_000015.10:g.63059598A>G	ExAC,TOPMed,gnomAD
rs730881134	p.Asp137Val	missense variant	-	NC_000015.10:g.63059598A>T	ExAC,TOPMed,gnomAD
rs1555408631	p.Asp137Glu	missense variant	-	NC_000015.10:g.63059599T>A	-
RCV000521302	p.Asp137Glu	missense variant	-	NC_000015.10:g.63059599T>A	ClinVar
RCV000159360	p.Asp137Val	missense variant	-	NC_000015.10:g.63059598A>T	ClinVar
rs879253758	p.Glu138Lys	missense variant	-	NC_000015.10:g.63059600G>A	-
RCV000234880	p.Glu138Lys	missense variant	-	NC_000015.10:g.63059600G>A	ClinVar
rs727504389	p.Glu139Val	missense variant	-	NC_000015.10:g.63059604A>T	-
RCV000154548	p.Glu139Val	missense variant	Primary dilated cardiomyopathy (DCM)	NC_000015.10:g.63059604A>T	ClinVar
RCV000159361	p.Lys140Gln	missense variant	-	NC_000015.10:g.63059606A>C	ClinVar
rs730881135	p.Lys140Gln	missense variant	-	NC_000015.10:g.63059606A>C	-
rs397516371	p.Met141Ile	missense variant	-	NC_000015.10:g.63059611G>C	-
RCV000036330	p.Met141Ile	missense variant	Primary dilated cardiomyopathy (DCM)	NC_000015.10:g.63059611G>C	ClinVar
rs1555408649	p.Glu142Lys	missense variant	-	NC_000015.10:g.63059612G>A	-
RCV000610234	p.Glu142Lys	missense variant	-	NC_000015.10:g.63059612G>A	ClinVar
rs730881136	p.Ile143Ser	missense variant	-	NC_000015.10:g.63059616T>G	-
RCV000159362	p.Ile143Ser	missense variant	-	NC_000015.10:g.63059616T>G	ClinVar
rs1206044252	p.Gln144Ter	stop gained	-	NC_000015.10:g.63059618C>T	TOPMed
RCV000769480	p.Gln144Arg	missense variant	Cardiomyopathy (CMYO)	NC_000015.10:g.63059619A>G	ClinVar
rs397516372	p.His153Tyr	missense variant	-	NC_000015.10:g.63059645C>T	gnomAD
RCV000156470	p.His153Arg	missense variant	-	NC_000015.10:g.63059646A>G	ClinVar
rs727505043	p.His153Arg	missense variant	-	NC_000015.10:g.63059646A>G	-
rs771515165	p.His153Gln	missense variant	-	NC_000015.10:g.63059647C>A	ExAC,gnomAD
rs397516372	p.His153Asp	missense variant	-	NC_000015.10:g.63059645C>G	gnomAD
RCV000527568	p.His153Asp	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63059645C>G	ClinVar
RCV000612144	p.Ile154Val	missense variant	-	NC_000015.10:g.63059648A>G	ClinVar
COSM1478250	p.Ala155Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000015.10:g.63059651G>C	NCI-TCGA Cosmic
RCV000736013	p.Asp159Asn	missense variant	Left ventricular noncompaction 9 (LVNC9)	NC_000015.10:g.63059663G>A	ClinVar
RCV000694039	p.Asp159Asn	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63059663G>A	ClinVar
RCV000036336	p.Arg160His	missense variant	Primary dilated cardiomyopathy (DCM)	NC_000015.10:g.63059667G>A	ClinVar
rs199476311	p.Arg160His	missense variant	-	NC_000015.10:g.63059667G>A	gnomAD
COSM1373913	p.Arg160Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000015.10:g.63059666C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Val165Leu	missense variant	-	NC_000015.10:g.63060869G>T	NCI-TCGA
RCV000221536	p.Ala166Thr	missense variant	Primary dilated cardiomyopathy (DCM)	NC_000015.10:g.63060872G>A	ClinVar
rs876657662	p.Ala166Thr	missense variant	-	NC_000015.10:g.63060872G>A	-
COSM1478252	p.Arg167Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000015.10:g.63060875C>G	NCI-TCGA Cosmic
rs1555409095	p.Val170Ile	missense variant	-	NC_000015.10:g.63060884G>A	-
RCV000505992	p.Val170Ile	missense variant	-	NC_000015.10:g.63060884G>A	ClinVar
rs730881137	p.Ile171Met	missense variant	-	NC_000015.10:g.63060889C>G	gnomAD
rs774903903	p.Ile171Leu	missense variant	-	NC_000015.10:g.63060887A>C	ExAC,TOPMed,gnomAD
rs774903903	p.Ile171Val	missense variant	-	NC_000015.10:g.63060887A>G	ExAC,TOPMed,gnomAD
RCV000203900	p.Ile171Leu	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63060887A>C	ClinVar
RCV000159363	p.Ile171Met	missense variant	-	NC_000015.10:g.63060889C>G	ClinVar
rs760374266	p.Ile172Leu	missense variant	-	NC_000015.10:g.63060890A>C	ExAC,gnomAD
RCV000489447	p.Ile172Leu	missense variant	-	NC_000015.10:g.63060890A>C	ClinVar
RCV000159365	p.Ile172Met	missense variant	-	NC_000015.10:g.63060892T>G	ClinVar
RCV000620267	p.Ile172Phe	missense variant	-	NC_000015.10:g.63060890A>T	ClinVar
RCV000148916	p.Ile172Thr	missense variant	Primary familial hypertrophic cardiomyopathy (HCM)	NC_000015.10:g.63060891T>C	ClinVar
rs199476312	p.Ile172Thr	missense variant	-	NC_000015.10:g.63060891T>C	ESP,ExAC
rs760374266	p.Ile172Phe	missense variant	-	NC_000015.10:g.63060890A>T	ExAC,gnomAD
rs730881138	p.Ile172Met	missense variant	-	NC_000015.10:g.63060892T>G	-
rs886037905	p.Glu173Asp	missense variant	-	NC_000015.10:g.63060895G>C	gnomAD
RCV000240649	p.Glu173Asp	missense variant	Dilated cardiomyopathy 1Y (CMD1Y)	NC_000015.10:g.63060895G>C	ClinVar
RCV000036340	p.Asp175Asn	missense variant	Primary familial hypertrophic cardiomyopathy (HCM)	NC_000015.10:g.63060899G>A	ClinVar
RCV000474684	p.Asp175Asn	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63060899G>A	ClinVar
RCV000013272	p.Asp175Asn	missense variant	Familial hypertrophic cardiomyopathy 3 (CMH3)	NC_000015.10:g.63060899G>A	ClinVar
RCV000622165	p.Asp175Asn	missense variant	-	NC_000015.10:g.63060899G>A	ClinVar
RCV000243279	p.Asp175Gly	missense variant	-	NC_000015.10:g.63060900A>G	ClinVar
rs104894503	p.Asp175Asn	missense variant	-	NC_000015.10:g.63060899G>A	TOPMed,gnomAD
rs104894503	p.Asp175Asn	missense variant	Cardiomyopathy, familial hypertrophic 3 (CMH3)	NC_000015.10:g.63060899G>A	UniProt,dbSNP
VAR_007601	p.Asp175Asn	missense variant	Cardiomyopathy, familial hypertrophic 3 (CMH3)	NC_000015.10:g.63060899G>A	UniProt
rs886039024	p.Asp175Gly	missense variant	-	NC_000015.10:g.63060900A>G	-
RCV000159366	p.Asp175Asn	missense variant	-	NC_000015.10:g.63060899G>A	ClinVar
rs397516375	p.Arg178His	missense variant	-	NC_000015.10:g.63060909G>A	-
rs367606352	p.Arg178Cys	missense variant	-	NC_000015.10:g.63060908C>T	ESP,ExAC
RCV000036341	p.Arg178His	missense variant	-	NC_000015.10:g.63060909G>A	ClinVar
RCV000024576	p.Glu180Val	missense variant	-	NC_000015.10:g.63060915A>T	ClinVar
RCV000013271	p.Glu180Gly	missense variant	Familial hypertrophic cardiomyopathy 3 (CMH3)	NC_000015.10:g.63060915A>G	ClinVar
rs104894502	p.Glu180Gly	missense variant	Cardiomyopathy, familial hypertrophic 3 (CMH3)	NC_000015.10:g.63060915A>G	UniProt,dbSNP
VAR_007602	p.Glu180Gly	missense variant	Cardiomyopathy, familial hypertrophic 3 (CMH3)	NC_000015.10:g.63060915A>G	UniProt
rs104894502	p.Glu180Val	missense variant	Cardiomyopathy, familial hypertrophic 3 (CMH3)	NC_000015.10:g.63060915A>T	UniProt,dbSNP
VAR_029452	p.Glu180Val	missense variant	Cardiomyopathy, familial hypertrophic 3 (CMH3)	NC_000015.10:g.63060915A>T	UniProt
rs1555409132	p.Glu180Gln	missense variant	-	NC_000015.10:g.63060914G>C	-
RCV000628948	p.Glu180Gln	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63060914G>C	ClinVar
RCV000159367	p.Glu180Gly	missense variant	-	NC_000015.10:g.63060915A>G	ClinVar
NCI-TCGA novel	p.Arg182Trp	missense variant	-	NC_000015.10:g.63060920C>T	NCI-TCGA
RCV000853436	p.Ala183Val	missense variant	Bicuspid aortic valve	NC_000015.10:g.63060924C>T	ClinVar
rs397516376	p.Ala183Val	missense variant	-	NC_000015.10:g.63060924C>T	TOPMed,gnomAD
RCV000159403	p.Glu184Ter	frameshift	-	NC_000015.10:g.63060927del	ClinVar
rs199476314	p.Leu185Arg	missense variant	-	NC_000015.10:g.63060930T>G	-
RCV000024577	p.Leu185Arg	missense variant	-	NC_000015.10:g.63060930T>G	ClinVar
rs727504264	p.Glu187Gln	missense variant	-	NC_000015.10:g.63060935G>C	-
rs786204411	p.Glu187Val	missense variant	-	NC_000015.10:g.63060936A>T	-
RCV000154247	p.Glu187Gln	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63060935G>C	ClinVar
RCV000253438	p.Glu187Val	missense variant	-	NC_000015.10:g.63060936A>T	ClinVar
rs730881139	p.Cys190Gly	missense variant	-	NC_000015.10:g.63061717T>G	TOPMed,gnomAD
rs730881139	p.Cys190Arg	missense variant	-	NC_000015.10:g.63061717T>C	TOPMed,gnomAD
RCV000628953	p.Ala191Val	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63061721_63061722delinsTT	ClinVar
rs772303740	p.Ala191Val	missense variant	-	NC_000015.10:g.63061721C>T	ExAC,gnomAD
rs730881154	p.Ala191Val	missense variant	-	NC_000015.10:g.63061721_63061722delinsTT	-
RCV000159404	p.Ala191Val	missense variant	-	NC_000015.10:g.63061721_63061722delinsTT	ClinVar
rs199476315	p.Glu192Lys	missense variant	-	NC_000015.10:g.63061723G>A	-
rs199476315	p.Glu192Lys	missense variant	Left ventricular non-compaction 9 (LVNC9)	NC_000015.10:g.63061723G>A	UniProt,dbSNP
VAR_070121	p.Glu192Lys	missense variant	Left ventricular non-compaction 9 (LVNC9)	NC_000015.10:g.63061723G>A	UniProt
RCV000526765	p.Glu192Lys	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63061723G>A	ClinVar
rs1555409508	p.Glu195Lys	missense variant	-	NC_000015.10:g.63061732G>A	-
RCV000618099	p.Glu195Lys	missense variant	-	NC_000015.10:g.63061732G>A	ClinVar
COSM4056092	p.Glu196Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000015.10:g.63061735G>T	NCI-TCGA Cosmic
rs730881140	p.Lys198Glu	missense variant	-	NC_000015.10:g.63061741A>G	-
RCV000159373	p.Lys198Glu	missense variant	-	NC_000015.10:g.63061741A>G	ClinVar
COSM700771	p.Lys198Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000015.10:g.63061742A>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Val200GluPheSerTerUnk	frameshift	-	NC_000015.10:g.63061747_63061748insAGTCC	NCI-TCGA
NCI-TCGA novel	p.Val200GluPheSerTerUnk	frameshift	-	NC_000015.10:g.63061746_63061747insGA	NCI-TCGA
RCV000159374	p.Thr201Met	missense variant	-	NC_000015.10:g.63061751C>T	ClinVar
rs730881141	p.Thr201Met	missense variant	-	NC_000015.10:g.63061751C>T	-
RCV000687999	p.Thr201Met	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63061751C>T	ClinVar
rs397516486	p.Asn203Lys	missense variant	-	NC_000015.10:g.63061758C>G	-
RCV000036629	p.Asn203Lys	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63061758C>G	ClinVar
rs1555409523	p.Asn203Asp	missense variant	-	NC_000015.10:g.63061756A>G	-
RCV000629029	p.Asn203Asp	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63061756A>G	ClinVar
RCV000144846	p.Leu207Ter	frameshift	Cardiomyopathy (CMYO)	NC_000015.10:g.63061769del	ClinVar
rs730881159	p.Ala209Thr	missense variant	-	NC_000015.10:g.63061774G>A	-
RCV000159411	p.Ala209Thr	missense variant	-	NC_000015.10:g.63061774G>A	ClinVar
COSM4056095	p.Gln210Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000015.10:g.63061778A>G	NCI-TCGA Cosmic
rs777139450	p.Gln210Pro	missense variant	-	NC_000015.10:g.63061778A>C	ExAC,gnomAD
rs397516487	p.Ala211Gly	missense variant	-	NC_000015.10:g.63061781C>G	-
RCV000036630	p.Ala211Gly	missense variant	-	NC_000015.10:g.63061781C>G	ClinVar
rs769951937	p.Glu212Val	missense variant	-	NC_000015.10:g.63061784A>T	ExAC,gnomAD
RCV000584812	p.Glu212Val	missense variant	Familial hypertrophic cardiomyopathy 1 (CMH1)	NC_000015.10:g.63061784A>T	ClinVar
RCV000786232	p.Lys213Gln	missense variant	-	NC_000015.10:g.63061786A>C	ClinVar
rs1382149754	p.Tyr214Cys	missense variant	-	NC_000015.10:g.63062216A>G	gnomAD
rs199476316	p.Ser215Leu	missense variant	-	NC_000015.10:g.63062219C>T	ExAC,gnomAD
RCV000168063	p.Ser215Leu	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63062219C>T	ClinVar
rs1265700466	p.Gln216Glu	missense variant	-	NC_000015.10:g.63062221C>G	TOPMed
rs727503518	p.Asp219Asn	missense variant	-	NC_000015.10:g.63062230G>A	-
RCV000152120	p.Asp219Asn	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63062230G>A	ClinVar
rs763069444	p.Arg220Lys	missense variant	-	NC_000015.10:g.63062234G>A	ExAC,gnomAD
NCI-TCGA novel	p.Glu222Gln	missense variant	-	NC_000015.10:g.63062239G>C	NCI-TCGA
COSM3794291	p.Glu224Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000015.10:g.63062245G>C	NCI-TCGA Cosmic
RCV000159379	p.Ile225Val	missense variant	-	NC_000015.10:g.63062248A>G	ClinVar
NCI-TCGA novel	p.Ile225Asn	missense variant	-	NC_000015.10:g.63062249T>A	NCI-TCGA
rs193922410	p.Ile225Val	missense variant	-	NC_000015.10:g.63062248A>G	gnomAD
RCV000030569	p.Ile225Val	missense variant	-	NC_000015.10:g.63062248A>G	ClinVar
rs730881144	p.Lys226Arg	missense variant	-	NC_000015.10:g.63062252A>G	-
RCV000036352	p.Lys226Gln	missense variant	-	NC_000015.10:g.63062251A>C	ClinVar
rs397516383	p.Lys226Gln	missense variant	-	NC_000015.10:g.63062251A>C	-
RCV000159380	p.Lys226Arg	missense variant	-	NC_000015.10:g.63062252A>G	ClinVar
rs1368991319	p.Val227Ile	missense variant	-	NC_000015.10:g.63062254G>A	TOPMed
rs1114167356	p.Ser229Phe	missense variant	-	NC_000015.10:g.63062261C>T	-
RCV000491210	p.Ser229Phe	missense variant	Atrial septal defect 1 (ASD1)	NC_000015.10:g.63062261C>T	ClinVar
RCV000695968	p.Asp230Asn	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63062263G>A	ClinVar
RCV000036354	p.Asp230Asn	missense variant	Primary dilated cardiomyopathy (DCM)	NC_000015.10:g.63062263G>A	ClinVar
rs199476317	p.Asp230Asn	missense variant	-	NC_000015.10:g.63062263G>A	-
RCV000024580	p.Asp230Asn	missense variant	-	NC_000015.10:g.63062263G>A	ClinVar
RCV000850515	p.Asp230Asn	missense variant	Familial hypertrophic cardiomyopathy 3 (CMH3)	NC_000015.10:g.63062263G>A	ClinVar
rs397516385	p.Lys231Arg	missense variant	-	NC_000015.10:g.63062267A>G	-
RCV000036355	p.Lys231Arg	missense variant	-	NC_000015.10:g.63062267A>G	ClinVar
rs1307911763	p.Glu234Asp	missense variant	-	NC_000015.10:g.63062277G>C	gnomAD
COSM3816492	p.Glu236Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000015.10:g.63062581G>C	NCI-TCGA Cosmic
RCV000159384	p.Arg238Trp	missense variant	Cardiomyopathy (CMYO)	NC_000015.10:g.63062585C>T	ClinVar
rs397516386	p.Arg238Trp	missense variant	-	NC_000015.10:g.63062585C>T	-
RCV000024591	p.Ala239Thr	missense variant	-	NC_000015.10:g.63062588G>A	ClinVar
RCV000471524	p.Ala239Thr	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63062588G>A	ClinVar
rs199476318	p.Ala239Thr	missense variant	-	NC_000015.10:g.63062588G>A	-
RCV000036357	p.Ala242Val	missense variant	-	NC_000015.10:g.63062598C>T	ClinVar
rs397516387	p.Ala242Val	missense variant	-	NC_000015.10:g.63062598C>T	gnomAD
RCV000770516	p.Arg244Lys	missense variant	Cardiomyopathy (CMYO)	NC_000015.10:g.63062604G>A	ClinVar
RCV000036359	p.Ser245Leu	missense variant	-	NC_000015.10:g.63062607C>T	ClinVar
rs397516388	p.Ser245Leu	missense variant	-	NC_000015.10:g.63062607C>T	-
rs760516389	p.Thr247Asn	missense variant	-	NC_000015.10:g.63062613C>A	ExAC
RCV000159412	p.Lys248Thr	missense variant	-	NC_000015.10:g.63062616A>C	ClinVar
rs730881160	p.Lys248Thr	missense variant	-	NC_000015.10:g.63062616A>C	-
rs199476319	p.Lys248Glu	missense variant	Left ventricular non-compaction 9 (LVNC9)	NC_000015.10:g.63062615A>G	UniProt,dbSNP
VAR_070122	p.Lys248Glu	missense variant	Left ventricular non-compaction 9 (LVNC9)	NC_000015.10:g.63062615A>G	UniProt
RCV000054794	p.Lys248Glu	missense variant	Left ventricular noncompaction 9 (LVNC9)	NC_000015.10:g.63062615A>G	ClinVar
rs786204412	p.Leu249Trp	missense variant	-	NC_000015.10:g.63062619T>G	-
NCI-TCGA novel	p.Leu249Met	missense variant	-	NC_000015.10:g.63062618T>A	NCI-TCGA
RCV000208366	p.Leu249Trp	missense variant	Primary familial hypertrophic cardiomyopathy (HCM)	NC_000015.10:g.63062619T>G	ClinVar
rs1288856499	p.Lys251Thr	missense variant	-	NC_000015.10:g.63062625A>C	TOPMed
rs1375629623	p.Ser252Ile	missense variant	-	NC_000015.10:g.63062628G>T	TOPMed,gnomAD
RCV000766951	p.Asp254Glu	missense variant	-	NC_000015.10:g.63062635T>G	ClinVar
rs727504354	p.Asp254Glu	missense variant	-	NC_000015.10:g.63062635T>G	-
rs727504354	p.Asp254Glu	missense variant	-	NC_000015.10:g.63062635T>A	-
RCV000223807	p.Asp254Glu	missense variant	-	NC_000015.10:g.63062635T>A	ClinVar
RCV000505777	p.Asp254Glu	missense variant	-	NC_000015.10:g.63062635T>G	ClinVar
RCV000036360	p.Glu259Lys	missense variant	-	NC_000015.10:g.63064066G>A	ClinVar
rs397516389	p.Glu259Gln	missense variant	-	NC_000015.10:g.63064066G>C	ExAC,gnomAD
RCV000159351	p.Glu259Gln	missense variant	-	NC_000015.10:g.63064066G>C	ClinVar
rs397516389	p.Glu259Lys	missense variant	-	NC_000015.10:g.63064066G>A	ExAC,gnomAD
rs758506771	p.Ala262Ser	missense variant	-	NC_000015.10:g.63064075G>T	ExAC,TOPMed,gnomAD
RCV000532880	p.Ala262Thr	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63064075G>A	ClinVar
rs758506771	p.Ala262Thr	missense variant	-	NC_000015.10:g.63064075G>A	ExAC,TOPMed,gnomAD
RCV000768534	p.Gln263Glu	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63064078C>G	ClinVar
rs730881147	p.Gln263Glu	missense variant	-	NC_000015.10:g.63064078C>G	-
RCV000159386	p.Gln263Glu	missense variant	-	NC_000015.10:g.63064078C>G	ClinVar
rs397516390	p.Lys264Glu	missense variant	-	NC_000015.10:g.63064081A>G	-
RCV000036361	p.Lys264Glu	missense variant	-	NC_000015.10:g.63064081A>G	ClinVar
RCV000822102	p.Lys264Glu	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63064081A>G	ClinVar
rs371934474	p.Lys266Arg	missense variant	-	NC_000015.10:g.63064088A>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000154863	p.Lys266Arg	missense variant	-	NC_000015.10:g.63064088A>G	ClinVar
RCV000475992	p.Lys266Arg	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63064088A>G	ClinVar
RCV000624321	p.Lys266Arg	missense variant	Left ventricular noncompaction	NC_000015.10:g.63064088A>G	ClinVar
rs1235668647	p.Tyr267Cys	missense variant	-	NC_000015.10:g.63064091A>G	TOPMed
RCV000612828	p.Lys268Glu	missense variant	-	NC_000015.10:g.63064093A>G	ClinVar
rs1555410433	p.Lys268Glu	missense variant	-	NC_000015.10:g.63064093A>G	-
rs1395706088	p.Lys268Arg	missense variant	-	NC_000015.10:g.63064094A>G	gnomAD
rs1342749492	p.Ala269Gly	missense variant	-	NC_000015.10:g.63064097C>G	gnomAD
rs1555410445	p.Ile270Val	missense variant	-	NC_000015.10:g.63064099A>G	-
RCV000538492	p.Ile270Val	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63064099A>G	ClinVar
rs1278119163	p.Ser271Asn	missense variant	-	NC_000015.10:g.63064103G>A	gnomAD
rs755226348	p.Glu272Lys	missense variant	-	NC_000015.10:g.63064105G>A	ExAC,TOPMed,gnomAD
rs727503519	p.Glu272Gly	missense variant	-	NC_000015.10:g.63064106A>G	-
RCV000152123	p.Glu272Ala	missense variant	-	NC_000015.10:g.63064106A>C	ClinVar
rs727503519	p.Glu272Ala	missense variant	-	NC_000015.10:g.63064106A>C	-
RCV000505744	p.Glu272Gly	missense variant	-	NC_000015.10:g.63064106A>G	ClinVar
rs199476320	p.Ala277Gly	missense variant	-	NC_000015.10:g.63064121C>G	TOPMed
RCV000036365	p.Ala277Gly	missense variant	-	NC_000015.10:g.63064121C>G	ClinVar
RCV000024592	p.Ala277Val	missense variant	-	NC_000015.10:g.63064121C>T	ClinVar
rs149659674	p.Ala277Thr	missense variant	-	NC_000015.10:g.63064120G>A	ESP,ExAC,TOPMed,gnomAD
rs199476320	p.Ala277Val	missense variant	-	NC_000015.10:g.63064121C>T	TOPMed
RCV000766952	p.Ala277Gly	missense variant	-	NC_000015.10:g.63064121C>G	ClinVar
RCV000036362	p.Ala277Thr	missense variant	-	NC_000015.10:g.63064120G>A	ClinVar
rs730881161	p.Leu278Val	missense variant	-	NC_000015.10:g.63064123C>G	gnomAD
rs730881161	p.Leu278Phe	missense variant	-	NC_000015.10:g.63064123C>T	gnomAD
rs397516392	p.Asn279His	missense variant	-	NC_000015.10:g.63064126A>C	-
RCV000036366	p.Asn279His	missense variant	-	NC_000015.10:g.63064126A>C	ClinVar
RCV000788149	p.Asn279His	missense variant	-	NC_000015.10:g.63064126A>C	ClinVar
rs777635889	p.Asp280Asn	missense variant	-	NC_000015.10:g.63064129G>A	ExAC,gnomAD
RCV000036368	p.Met281Val	missense variant	-	NC_000015.10:g.63064132A>G	ClinVar
RCV000766955	p.Met281Val	missense variant	-	NC_000015.10:g.63064132A>G	ClinVar
RCV000553548	p.Met281Val	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63064132A>G	ClinVar
rs199476321	p.Met281Thr	missense variant	-	NC_000015.10:g.63064133T>C	TOPMed,gnomAD
rs397516394	p.Met281Val	missense variant	-	NC_000015.10:g.63064132A>G	ExAC,gnomAD
RCV000154219	p.Met281Thr	missense variant	-	NC_000015.10:g.63064133T>C	ClinVar
rs397516395	p.Thr282Ser	missense variant	-	NC_000015.10:g.63064136C>G	1000Genomes,ExAC,TOPMed,gnomAD
RCV000310785	p.Thr282Ser	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63064136C>G	ClinVar
rs745520822	p.Ile284Thr	missense variant	-	NC_000015.10:g.63064142T>C	ExAC,gnomAD
RCV000699606	p.Ile284Val	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63064141A>G	ClinVar
RCV000498754	p.Ile284Thr	missense variant	Hypertrophic cardiomyopathy	NC_000015.10:g.63064142T>C	ClinVar
rs199476322	p.Ile284Val	missense variant	-	NC_000015.10:g.63064141A>G	-
rs759481997	p.Ile284Met	missense variant	-	NC_000015.10:g.63065896A>G	ExAC,gnomAD
RCV000152124	p.Ile284Val	missense variant	-	NC_000015.10:g.63064141A>G	ClinVar
RCV000024594	p.Ile284Val	missense variant	-	NC_000015.10:g.63064141A>G	ClinVar

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0003851	Arteriosclerosis Obliterans	disease	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0007193	Cardiomyopathy, Dilated	group	BEFREE;CLINVAR;GENOMICS_ENGLAND;HPO;LHGDN
C0007194	Hypertrophic Cardiomyopathy	disease	BEFREE;CLINGEN;CLINVAR;GENOMICS_ENGLAND;HPO;LHGDN
C0007959	Charcot-Marie-Tooth Disease	disease	GENOMICS_ENGLAND
C0009081	Congenital clubfoot	disease	BEFREE
C0009402	Colorectal Carcinoma	disease	BEFREE
C0014859	Esophageal Neoplasms	group	CTD_human
C0017661	IGA Glomerulonephritis	disease	BEFREE
C0018798	Congenital Heart Defects	group	BEFREE
C0018801	Heart failure	disease	BEFREE;HPO
C0018802	Congestive heart failure	disease	BEFREE;HPO
C0020538	Hypertensive disease	group	CTD_human
C0022548	Keloid	phenotype	CTD_human
C0023893	Liver Cirrhosis, Experimental	disease	CTD_human
C0025202	melanoma	disease	BEFREE
C0026848	Myopathy	group	BEFREE
C0027627	Neoplasm Metastasis	phenotype	BEFREE
C0030552	Paresis	phenotype	BEFREE
C0030567	Parkinson Disease	disease	GWASCAT
C0032181	Platelet Count measurement	phenotype	GWASCAT
C0039446	Telangiectasis	disease	BEFREE
C0039685	Tetralogy of Fallot	disease	CLINVAR
C0042514	Tachycardia, Ventricular	disease	HPO
C0085612	Ventricular arrhythmia	disease	BEFREE
C0149721	Left Ventricular Hypertrophy	disease	BEFREE
C0151786	Muscle Weakness	phenotype	BEFREE
C0200665	Platelet mean volume determination (procedure)	phenotype	GWASCAT;GWASDB
C0202117	Low density lipoprotein cholesterol measurement	phenotype	GWASDB
C0206157	Myopathies, Nemaline	disease	BEFREE
C0206698	Cholangiocarcinoma	disease	BEFREE
C0220668	Congenital contractural arachnodactyly	disease	BEFREE
C0262659	Vagina Carcinoma	disease	BEFREE
C0264732	Cardiac dilatation	disease	BEFREE
C0264886	Conduction disorder of the heart	group	GENOMICS_ENGLAND
C0278488	Carcinoma breast stage IV	disease	BEFREE
C0279626	Squamous cell carcinoma of esophagus	disease	BEFREE;CTD_human
C0302592	Cervix carcinoma	disease	BEFREE
C0340425	Hypertrophic cardiomyopathy without obstruction	disease	BEFREE
C0340427	Familial dilated cardiomyopathy	disease	BEFREE;ORPHANET
C0344975	Pulmonary Atresia with Intact Ventricular Septum	disease	CLINVAR
C0345905	Intrahepatic Cholangiocarcinoma	disease	BEFREE
C0427565	Platelet distribution width measurement	phenotype	GWASCAT
C0524620	Metabolic Syndrome X	disease	BEFREE
C0546837	Malignant neoplasm of esophagus	disease	CTD_human
C0596263	Carcinogenesis	phenotype	BEFREE
C0597124	Obstructive asymmetric septal hypertrophy	disease	CTD_human
C0678222	Breast Carcinoma	disease	BEFREE
C0700053	Idiopathic hypertrophic subaortic stenosis	disease	CTD_human
C0700323	Observation of Neuromuscular Block	disease	BEFREE
C0745103	Hyperlipoproteinemia Type IIa	disease	BEFREE
C0751656	Nemaline Myopathy, Autosomal Dominant	disease	BEFREE
C0751657	Nemaline Myopathy, Autosomal Recessive	disease	BEFREE
C0877015	Pelvic Organ Prolapse	disease	BEFREE
C0878544	Cardiomyopathies	group	BEFREE
C0949658	Cardiomyopathy, Hypertrophic, Familial	disease	BEFREE;CLINGEN;CLINVAR;CTD_human;LHGDN
C1292769	Precursor B-cell lymphoblastic leukemia	disease	BEFREE
C1318035	Platelet distribution width result	phenotype	GWASCAT
C1445957	Serum total cholesterol measurement	phenotype	GWASDB
C1449563	Cardiomyopathy, Familial Idiopathic	disease	BEFREE
C1458155	Mammary Neoplasms	group	BEFREE;LHGDN
C1527249	Colorectal Cancer	disease	BEFREE
C1533847	Disorder of skeletal muscle	group	BEFREE
C1704272	Benign Prostatic Hyperplasia	disease	BEFREE
C1861863	CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 (disorder)	disease	CLINVAR;CTD_human;UNIPROT
C1862389	ATRIAL SEPTAL DEFECT 1	disease	CLINVAR
C1960469	Left ventricular noncompaction	disease	BEFREE;ORPHANET
C2678476	Cardiomyopathy, Dilated, 1y	disease	CLINVAR;CTD_human;UNIPROT
C3710589	Cap Myopathy	disease	BEFREE
C3805278	Extrahepatic Cholangiocarcinoma	disease	BEFREE
C3808145	LEFT VENTRICULAR NONCOMPACTION 9	disease	CLINVAR;UNIPROT
C3887486	Interstitial lung fibrosis	phenotype	BEFREE
C4021133	Left ventricular noncompaction cardiomyopathy	disease	BEFREE;GENOMICS_ENGLAND
C4025298	Effort-induced polymorphic ventricular tachycardias	phenotype	CLINVAR

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0003779	actin binding	TAS
GO:0005200	structural constituent of cytoskeleton	TAS
GO:0005515	protein binding	IPI
GO:0008092	cytoskeletal protein binding	IPI
GO:0008307	structural constituent of muscle	TAS
GO:0042802	identical protein binding	ISS
GO:0042803	protein homodimerization activity	ISS
GO:0046982	protein heterodimerization activity	ISS
GO:0051015	actin filament binding	ISS
GO:0051015	actin filament binding	IBA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001701	in utero embryonic development	IEA
GO:0003065	positive regulation of heart rate by epinephrine	ISS
GO:0006936	muscle contraction	IBA
GO:0006936	muscle contraction	TAS
GO:0006937	regulation of muscle contraction	TAS
GO:0007010	cytoskeleton organization	TAS
GO:0007015	actin filament organization	IBA
GO:0008016	regulation of heart contraction	TAS
GO:0008360	regulation of cell shape	IMP
GO:0030049	muscle filament sliding	ISS
GO:0030049	muscle filament sliding	TAS
GO:0030336	negative regulation of cell migration	ISS
GO:0031529	ruffle organization	ISS
GO:0032781	positive regulation of ATPase activity	ISS
GO:0034614	cellular response to reactive oxygen species	IEP
GO:0042060	wound healing	ISS
GO:0045214	sarcomere organization	IMP
GO:0045785	positive regulation of cell adhesion	ISS
GO:0051496	positive regulation of stress fiber assembly	ISS
GO:0055010	ventricular cardiac muscle tissue morphogenesis	IMP
GO:0060048	cardiac muscle contraction	IMP
GO:0060048	cardiac muscle contraction	IBA
GO:1904706	negative regulation of vascular smooth muscle cell proliferation	IMP
GO:1904753	negative regulation of vascular associated smooth muscle cell migration	IMP

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0001725	stress fiber	IDA
GO:0005829	cytosol	IDA
GO:0005829	cytosol	TAS
GO:0005856	cytoskeleton	TAS
GO:0005862	muscle thin filament tropomyosin	TAS
GO:0005884	actin filament	IBA
GO:0015629	actin cytoskeleton	IDA
GO:0030017	sarcomere	TAS
GO:0032059	bleb	IMP
GO:0032587	ruffle membrane	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-390522	Striated Muscle Contraction	TAS
R-HSA-397014	Muscle contraction	TAS
R-HSA-445355	Smooth Muscle Contraction	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	1,2-dithiol-3-thione results in increased expression of TPM1 mRNA	19162173
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TPM1 mRNA	22698814
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TPM1 mRNA	16997883
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TPM1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TPM1 mRNA	16054899
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of TPM1 protein	26558463
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of TPM1 mRNA	25380136; 30723492;
C016614	1-nitronaphthalene	1-nitronaphthalene metabolite binds to TPM1 protein	16453347
C029790	2,2',3',4,4',5-hexachlorobiphenyl	2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of TPM1 mRNA	23829299
C477694	2,2',4,4',5-brominated diphenyl ether	2,2',4,4',5-brominated diphenyl ether results in decreased expression of TPM1 protein	18550172
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TPM1 mRNA	19167446
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene affects the expression of TPM1 mRNA	21346803
C009407	2,5,2',5'-tetrachlorobiphenyl	2,5,2',5'-tetrachlorobiphenyl results in increased expression of TPM1 mRNA	23829299
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene affects the expression of TPM1 mRNA	21346803
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in increased expression of TPM1 mRNA	29704546
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of TPM1 mRNA	29704546
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TPM1 mRNA	28973690
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TPM1 mRNA	19692669
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of TPM1 mRNA	21983209
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of TPM1 mRNA	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPM1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA	27188386
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TPM1 mRNA	19150397
D015124	8-Bromo Cyclic Adenosine Monophosphate	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TPM1 mRNA	16997883
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TPM1 mRNA	22485181
D000082	Acetaminophen	Acetaminophen results in decreased expression of TPM1 mRNA	21420995
D000082	Acetaminophen	Acetaminophen results in increased expression of TPM1 mRNA	22112502
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]	15910882
D020106	Acrylamide	Acrylamide results in decreased expression of TPM1 mRNA	28606764
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TPM1 mRNA	27153756
D000447	Aldehydes	Aldehydes results in increased expression of TPM1 mRNA	25014914
D000499	Allylamine	Acetylcysteine inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]	15910882
D000499	Allylamine	Allylamine results in increased expression of TPM1 mRNA	15910882
D000499	Allylamine	Allylamine results in increased expression of TPM1 protein	15910882
D000499	Allylamine	Hydrogen Peroxide inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]	15910882
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TPM1 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of TPM1 protein	16483693
C059765	amphotericin B, deoxycholate drug combination	amphotericin B, deoxycholate drug combination results in increased expression of TPM1 mRNA	22863853
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of TPM1 mRNA	24449571
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite affects the expression of TPM1 mRNA	17331233
D001280	Atrazine	Atrazine results in decreased expression of TPM1 mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TPM1 mRNA	19770486; 22610609;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TPM1 mRNA	22228805
C038328	BEP protocol	BEP protocol results in increased expression of TPM1 mRNA	18987330
D000077610	Bexarotene	Bexarotene results in increased expression of TPM1 mRNA	16648578
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of TPM1 mRNA	30951980
C006780	bisphenol A	bisphenol A affects the expression of TPM1 mRNA	20170705
C006780	bisphenol A	bisphenol A results in decreased expression of TPM1 mRNA	25047013; 29275510;
C006780	bisphenol A	[bisphenol A co-treated with Tretinoin] results in decreased expression of TPM1 mRNA	30951980
C006780	bisphenol A	bisphenol A results in increased expression of TPM1 mRNA	30951980
C006780	bisphenol A	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TPM1 promoter	23359474
C006780	bisphenol A	bisphenol A results in decreased expression of TPM1 mRNA	27178563; 30816183;
C006780	bisphenol A	bisphenol A results in increased expression of TPM1 mRNA	25181051
C006780	bisphenol A	bisphenol A affects the expression of TPM1 mRNA	15364205
C000611646	bisphenol F	[bisphenol F co-treated with Tretinoin] results in decreased expression of TPM1 mRNA	30951980
C000611646	bisphenol F	bisphenol F results in increased expression of TPM1 mRNA	30951980
D001761	Bleomycin	Bleomycin results in increased expression of TPM1 protein	25933445
D000069286	Bortezomib	Bortezomib results in increased expression of TPM1 mRNA	20977926
C032036	bromobenzene	bromobenzene metabolite binds to TPM1 protein	17305373
D002065	Buspirone	Buspirone results in decreased expression of TPM1 mRNA	24136188
C018475	butyraldehyde	butyraldehyde results in increased expression of TPM1 mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of TPM1 mRNA	24376830
D002104	Cadmium	Cadmium results in decreased expression of TPM1 mRNA	17327700
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TPM1 mRNA	26472689
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TPM1 mRNA	17327700
C459604	candoxin	candoxin results in increased expression of TPM1 mRNA	16309724
D002220	Carbamazepine	Carbamazepine affects the expression of TPM1 mRNA	25979313
D002235	Carbofuran	[Hexachlorocyclohexane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of TPM1 mRNA	21075942
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TPM1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TPM1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TPM1 mRNA	22112502; 31150632;
D002251	Carbon Tetrachloride	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TPM1 mRNA]	31150632
D007631	Chlordecone	Chlordecone results in decreased expression of TPM1 mRNA	29458080
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of TPM1 mRNA	23650126; 25270620;
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TPM1 mRNA	20938992
D002857	Chromium	LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TPM1 mRNA]	16940432
D002922	Ciguatoxins	Ciguatoxins affects the expression of TPM1 mRNA	18353800
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of TPM1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of TPM1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of TPM1 mRNA	21151649
D002945	Cisplatin	Cisplatin results in decreased expression of TPM1 mRNA	22023808
D002945	Cisplatin	Cisplatin results in decreased expression of TPM1 protein	22023808
D002994	Clofibrate	Clofibrate results in increased expression of TPM1 mRNA	17585979
C480342	clothianidin	clothianidin results in increased expression of TPM1 mRNA	29044138
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TPM1 mRNA	19320972; 19376846;
D003375	Coumestrol	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TPM1 mRNA	19167446
C029892	cupric chloride	cupric chloride results in increased expression of TPM1 protein	29617964
C030973	cupric oxide	cupric oxide results in decreased expression of TPM1 mRNA	22077320
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of TPM1 mRNA	17654400
D003520	Cyclophosphamide	TPM1 protein affects the susceptibility to Cyclophosphamide	16217747
D016572	Cyclosporine	Cyclosporine results in decreased expression of TPM1 mRNA	25562108; 27989131;
C010902	decabromobiphenyl ether	decabromobiphenyl ether affects the expression of TPM1 mRNA	24834073
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of TPM1 mRNA	23914054
D064791	Desoxycorticosterone Acetate	[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in increased expression of TPM1 mRNA	22228705
D003907	Dexamethasone	[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TPM1 mRNA	16997883
D003907	Dexamethasone	Dexamethasone results in decreased expression of TPM1 mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TPM1 mRNA	28628672
D003907	Dexamethasone	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TPM1 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in decreased expression of TPM1 mRNA	22733784
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TPM1 mRNA	21266533
D003993	Dibutyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TPM1 promoter	23359474
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TPM1 mRNA	21266533; 21745491;
D004041	Dietary Fats	Dietary Fats results in decreased expression of TPM1 mRNA	25016146
D004041	Dietary Fats	Dietary Fats results in increased expression of TPM1 mRNA	18042831; 22609946;
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of TPM1 protein	31163220
D004051	Diethylhexyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TPM1 promoter	23359474
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TPM1 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TPM1 mRNA	18597072; 24535843;
D004052	Diethylnitrosamine	Troglitazone promotes the reaction [Diethylnitrosamine results in increased expression of TPM1 mRNA]	18597072
C039060	dihydroartemisinin	dihydroartemisinin analog binds to TPM1 protein	26340163
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of TPM1 mRNA	29581250
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of TPM1 mRNA	25380136
D004237	Diuron	Diuron results in decreased expression of TPM1 mRNA	25152437
D004237	Diuron	Diuron results in increased expression of TPM1 mRNA	21551480
C516138	dorsomorphin	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPM1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA	27188386
D004317	Doxorubicin	Doxorubicin affects the expression of TPM1 protein	29385562
D004317	Doxorubicin	Doxorubicin results in increased expression of TPM1 mRNA	28940058; 29803840;
D004317	Doxorubicin	TPM1 protein affects the susceptibility to Doxorubicin	16217747
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in decreased expression of TPM1 protein	16144979
D004317	Doxorubicin	Doxorubicin results in decreased expression of TPM1 protein	16144979
D004317	Doxorubicin	Doxorubicin results in increased oxidation of TPM1 protein	28818578
C070609	EMD 53998	EMD 53998 analog results in decreased expression of TPM1 mRNA	24977338
D004726	Endosulfan	Endosulfan results in decreased expression of TPM1 mRNA	29391264
C118739	entinostat	entinostat results in decreased expression of TPM1 mRNA	26272509
C118739	entinostat	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA	27188386
D004958	Estradiol	EGF protein promotes the reaction [Estradiol results in increased expression of TPM1 mRNA]	24758408
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in increased expression of TPM1 mRNA	30165855
D004958	Estradiol	Estradiol results in increased expression of TPM1 mRNA	24758408
D004958	Estradiol	Estradiol results in decreased expression of TPM1 mRNA	19484750
D004958	Estradiol	Estradiol affects the expression of TPM1 mRNA	15364205
D000431	Ethanol	Ethanol affects the splicing of TPM1 mRNA	30319688
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of TPM1 mRNA	20170705; 26865667;
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TPM1 mRNA	18936297
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TPM1 mRNA	12655037
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TPM1 mRNA	23129252
D017313	Fenretinide	Fenretinide results in increased expression of TPM1 mRNA	28973697
D018120	Finasteride	Finasteride results in increased expression of TPM1 mRNA	24136188
D005411	Flame Retardants	Flame Retardants results in decreased expression of TPM1 protein	18550172
D005472	Fluorouracil	TPM1 protein affects the susceptibility to Fluorouracil	16217747
D005473	Fluoxetine	Fluoxetine results in decreased expression of TPM1 mRNA	21852994
D005485	Flutamide	Flutamide results in decreased expression of TPM1 mRNA	21126777
D005485	Flutamide	Flutamide results in increased expression of TPM1 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TPM1 mRNA	20938992
C056933	fumonisin B1	fumonisin B1 results in increased expression of TPM1 mRNA	16221962
C039281	furan	furan results in increased expression of TPM1 mRNA	26194646
D019833	Genistein	Genistein results in decreased expression of TPM1 mRNA	20884965; 26865667;
D001556	Hexachlorocyclohexane	[Hexachlorocyclohexane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of TPM1 mRNA	21075942
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of TPM1 mRNA	21179406
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of TPM1 protein	21179406
D006861	Hydrogen Peroxide	Hydrogen Peroxide inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]	15910882
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of TPM1 mRNA	21396975
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TPM1 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TPM1 mRNA	25613284
D007545	Isoproterenol	Isoproterenol results in decreased expression of TPM1 mRNA	20003209
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of TPM1 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TPM1 mRNA	24796395
D007649	Ketamine	Ketamine results in increased expression of TPM1 mRNA	20080153
D019344	Lactic Acid	Lactic Acid results in increased expression of TPM1 mRNA	30851411
D008094	Lithium	Lithium results in decreased expression of TPM1 protein	18296634
D018021	Lithium Chloride	Lithium Chloride results in increased expression of TPM1 mRNA	23527032
D008694	Methamphetamine	Methamphetamine results in decreased expression of TPM1 mRNA	29802913
D008701	Methapyrilene	Methapyrilene results in increased expression of TPM1 mRNA	22484513
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TPM1 mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TPM1 mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of TPM1 protein	26558463
C008493	methylselenic acid	methylselenic acid results in increased expression of TPM1 mRNA	18548127
C051786	metolachlor	[Hexachlorocyclohexane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of TPM1 mRNA	21075942
D052998	Microcystins	Microcystins results in increased expression of TPM1 protein	22430071
D008942	Mitoxantrone	TPM1 protein affects the susceptibility to Mitoxantrone	16217747
C000627226	momfluorothrin	momfluorothrin results in decreased expression of TPM1 mRNA	28520973
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of TPM1 mRNA	16809437
C406082	monomethylarsonous acid	monomethylarsonous acid affects the expression of TPM1 protein	24625837
D037742	Nanotubes, Carbon	Nanotubes, Carbon affects the expression of TPM1 protein	22001959
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of TPM1 mRNA	25620056
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of TPM1 mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of TPM1 mRNA	25554681; 25620056;
C031721	naphthalene	naphthalene metabolite binds to TPM1 protein	16453347
C031721	naphthalene	naphthalene metabolite binds to TPM1 protein	15892573
D009281	Naphthalenes	Naphthalenes results in increased expression of TPM1 protein	17337753
C051752	nefazodone	nefazodone results in increased expression of TPM1 mRNA	24136188
D009525	Niacin	LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TPM1 mRNA]	16940432
D009532	Nickel	Nickel results in decreased expression of TPM1 mRNA	24768652; 25583101;
D009532	Nickel	Nickel results in increased expression of TPM1 mRNA	12540486
C028007	nickel monoxide	nickel monoxide results in increased expression of TPM1 mRNA	19167457
D009534	Niclosamide	Niclosamide results in increased expression of TPM1 mRNA	31398420
C012655	nimesulide	nimesulide results in increased expression of TPM1 mRNA	24136188
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of TPM1 protein	19716841
C025256	nonylphenol	nonylphenol affects the expression of TPM1 mRNA	15364205
D009966	Orphenadrine	Orphenadrine affects the expression of TPM1 mRNA	23665939
D000077150	Oxaliplatin	[Oxaliplatin co-treated with Topotecan] results in increased expression of TPM1 mRNA	25729387
D000077150	Oxaliplatin	Oxaliplatin results in increased expression of TPM1 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of TPM1 mRNA	26516004
D000073878	Palm Oil	Palm Oil results in increased expression of TPM1 mRNA	18042831
D052638	Particulate Matter	Particulate Matter results in decreased expression of TPM1 mRNA	29703138
D052638	Particulate Matter	Particulate Matter analog results in decreased expression of TPM1 mRNA	15541757
C410127	PCB 180	PCB 180 results in increased expression of TPM1 mRNA	23829299
C046012	pentanal	pentanal results in increased expression of TPM1 mRNA	26079696
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in increased expression of TPM1 protein	26168851
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of TPM1 mRNA	22237054
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of TPM1 mRNA	19162173
C058305	phenethyl isothiocyanate	TPM1 protein binds to phenethyl isothiocyanate	21838287
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TPM1 mRNA	24535843
D010634	Phenobarbital	Phenobarbital affects the expression of TPM1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of TPM1 mRNA	25270620
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPM1 mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of TPM1 mRNA	26272509
D010795	Phthalic Acids	Phthalic Acids results in increased expression of TPM1 mRNA	15728792
C006253	pirinixic acid	pirinixic acid results in decreased expression of TPM1 mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of TPM1 mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in increased expression of TPM1 mRNA	19162173
D011189	Potassium Chloride	[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in increased expression of TPM1 mRNA	22228705
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of TPM1 mRNA	22714537
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of TPM1 protein	23718831
D011374	Progesterone	Progesterone results in decreased expression of TPM1 mRNA	18037150; 21795739;
C005556	propionaldehyde	propionaldehyde results in increased expression of TPM1 mRNA	26079696
D011794	Quercetin	Quercetin results in increased expression of TPM1 mRNA	21632981
D011794	Quercetin	Quercetin results in decreased expression of TPM1 mRNA	18095365
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of TPM1 mRNA	14699072
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of TPM1 mRNA	16079270
D012176	Retinoids	Retinoids results in decreased expression of TPM1 protein	28886987
D000077154	Rosiglitazone	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TPM1 mRNA	16054899
D012524	Sarin	Sarin results in decreased expression of TPM1 mRNA	19522546
C015499	schizandrin B	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TPM1 mRNA]	31150632
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of TPM1 protein	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of TPM1 mRNA	25895662
D012834	Silver	Silver affects the expression of TPM1 mRNA	27131904
C009277	sodium arsenate	sodium arsenate results in decreased expression of TPM1 mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in increased expression of TPM1 mRNA	25270620
C017947	sodium arsenite	sodium arsenite results in decreased expression of TPM1 protein	29459688
C016104	sodium bichromate	sodium bichromate results in increased expression of TPM1 mRNA	25993096
D017673	Sodium Chloride, Dietary	[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in increased expression of TPM1 mRNA	22228705
D012999	Soman	Soman results in increased expression of TPM1 mRNA	19281266
C016766	sulforafan	TPM1 protein binds to sulforafan	21838287
C016766	sulforafan	sulforafan results in increased expression of TPM1 mRNA	30529165
D000077210	Sunitinib	Sunitinib results in increased expression of TPM1 mRNA	31533062
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of TPM1 mRNA	31299295
D013629	Tamoxifen	Tamoxifen affects the expression of TPM1 mRNA	14699072
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of TPM1 protein	27239688
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of TPM1 mRNA	29704546
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TPM1 mRNA	21570461; 26377647;
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TPM1 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TPM1 mRNA	18796159
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TPM1 mRNA	18796159
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TPM1 mRNA	27136898
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TPM1 protein	19201780
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TPM1 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of TPM1 mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in decreased expression of TPM1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of TPM1 protein	30291989
D019772	Topotecan	TPM1 protein affects the susceptibility to Topotecan	16217747
D019772	Topotecan	[Oxaliplatin co-treated with Topotecan] results in increased expression of TPM1 mRNA	25729387
D014212	Tretinoin	[bisphenol A co-treated with Tretinoin] results in decreased expression of TPM1 mRNA	30951980
D014212	Tretinoin	[bisphenol F co-treated with Tretinoin] results in decreased expression of TPM1 mRNA	30951980
D014212	Tretinoin	Tretinoin affects the expression of TPM1 protein	15789344
C032910	triadimefon	triadimefon results in decreased expression of TPM1 mRNA	26705709
C012589	trichostatin A	trichostatin A results in decreased expression of TPM1 mRNA	15901671
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM1 mRNA	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of TPM1 mRNA	26272509
C012589	trichostatin A	trichostatin A results in increased expression of TPM1 mRNA	26705709
D014260	Triclosan	Triclosan results in decreased expression of TPM1 mRNA	30510588
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TPM1 mRNA	26179874
D000077288	Troglitazone	Troglitazone promotes the reaction [Diethylnitrosamine results in increased expression of TPM1 mRNA]	18597072
D017974	Uranium Compounds	Uranium Compounds results in decreased expression of TPM1 mRNA	19654044
D014520	Urethane	Urethane results in decreased expression of TPM1 mRNA	16289808
C406224	valdecoxib	valdecoxib results in increased expression of TPM1 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased expression of TPM1 mRNA	15901671
D014635	Valproic Acid	Valproic Acid affects the expression of TPM1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of TPM1 mRNA	24935251; 28001369;
D014635	Valproic Acid	Valproic Acid results in increased expression of TPM1 mRNA	23179753
C034028	vanadyl sulfate	vanadyl sulfate results in decreased expression of TPM1 mRNA	16330358
D014640	Vancomycin	Vancomycin results in decreased expression of TPM1 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions analog results in decreased expression of TPM1 mRNA	15541757
C025643	vinclozolin	vinclozolin affects the expression of TPM1 mRNA	19015723
D014800	Vitallium	Vitallium analog results in decreased expression of TPM1 mRNA	23825117
D015032	Zinc	Zinc deficiency results in decreased expression of TPM1 mRNA	19111725
D015032	Zinc	Zinc deficiency results in decreased expression of TPM1 protein	22689922

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0007	Acetylation
KW-0009	Actin-binding
KW-0025	Alternative splicing
KW-0122	Cardiomyopathy
KW-0175	Coiled coil
KW-0963	Cytoplasm
KW-0206	Cytoskeleton
KW-0903	Direct protein sequencing
KW-0225	Disease mutation
KW-0514	Muscle protein
KW-0597	Phosphoprotein
KW-1185	Reference proteome

Interpro

InterPro ID	InterPro Term
IPR000533	Tropomyosin

PROSITE

PROSITE ID	PROSITE Term
PS00326	TROPOMYOSIN

Pfam

Pfam ID	Pfam Term
PF00261	Tropomyosin

Gene: TPM1

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Identified variants/mutations related to cleft phenotype

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction