| Tag | Content |
|---|---|
| Uniprot ID | P09493; B7Z5T7; D9YZV2; D9YZV3; D9YZV8; P09494; P10469; Q6DV89; Q6DV90; Q7Z6L8; Q86W64; Q96IK2; Q9UCI1; Q9UCI2; Q9UCY9; Q9Y427; |
| Entrez ID | 7168 |
| Genbank protein ID | AAT68295.1; AAH07433.1; EAW77627.1; BAH13023.1; EAW77622.1; ADL14506.1; AAA36771.1; AAA61226.1; EAW77623.1; ADL14500.1; EAW77619.1; ADL14504.1; AAH53545.1; ADL14501.1; EAW77628.1; AAA61225.1; AAT68294.1; AAH50473.1; CAB43309.2; CAA30930.1; AAA61227.1; |
| Genbank nucleotide ID | NM_001018004.1; NM_001330351.1; NM_001330344.1; XM_017022538.1; NM_000366.5; NM_001018008.1; NM_001018020.1; NM_001330346.1; NM_001018005.1; NM_001018007.1; NM_001018006.1; NM_001301244.1; |
| Ensembl protein ID | ENSP00000453941; ENSP00000267996; ENSP00000351022; ENSP00000288398; ENSP00000385107; ENSP00000334624; ENSP00000452879; ENSP00000453955; |
| Ensembl nucleotide ID | ENSG00000140416 |
| Gene name | Tropomyosin alpha-1 chain |
| Gene symbol | TPM1 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | CPO,CL/P |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 26792422 |
| Functional description | Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
| Sequence | MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY 60 SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 120 DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE 180 ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE 240 FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI 284 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.