CleftGeneDB-Search

Gene: HSPA5

Basic information

Tag	Content
Uniprot ID	P11021; B0QZ61; Q2EF78; Q9NPF1; Q9UK02;
Entrez ID	3309
Genbank protein ID	AAF42836.1; EAW87620.1; CAA61201.1; AAA52614.1; CAA42595.1; CAB71335.1; ABD04090.1; AAH20235.1; AAF13605.1;
Genbank nucleotide ID	NM_005347.4
Ensembl protein ID	ENSP00000324173
Ensembl nucleotide ID	ENSG00000044574
Gene name	Endoplasmic reticulum chaperone BiP
Gene symbol	HSPA5
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166).
Sequence	MKLSLVAAML LLLSAARAEE EDKKEDVGTV VGIDLGTTYS CVGVFKNGRV EIIANDQGNR 60 ITPSYVAFTP EGERLIGDAA KNQLTSNPEN TVFDAKRLIG RTWNDPSVQQ DIKFLPFKVV 120 EKKTKPYIQV DIGGGQTKTF APEEISAMVL TKMKETAEAY LGKKVTHAVV TVPAYFNDAQ 180 RQATKDAGTI AGLNVMRIIN EPTAAAIAYG LDKREGEKNI LVFDLGGGTF DVSLLTIDNG 240 VFEVVATNGD THLGGEDFDQ RVMEHFIKLY KKKTGKDVRK DNRAVQKLRR EVEKAKRALS 300 SQHQARIEIE SFYEGEDFSE TLTRAKFEEL NMDLFRSTMK PVQKVLEDSD LKKSDIDEIV 360 LVGGSTRIPK IQQLVKEFFN GKEPSRGINP DEAVAYGAAV QAGVLSGDQD TGDLVLLDVC 420 PLTLGIETVG GVMTKLIPRN TVVPTKKSQI FSTASDNQPT VTIKVYEGER PLTKDNHLLG 480 TFDLTGIPPA PRGVPQIEVT FEIDVNGILR VTAEDKGTGN KNKITITNDQ NRLTPEEIER 540 MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KLGGKLSSED KETMEKAVEE 600 KIEWLESHQD ADIEDFKAKK KELEEIVQPI ISKLYGSAGP PPTGEEDTAE KDEL 654

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
3IUC
3LDL
3LDN
3LDO
3LDP
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
6DFM
6DFO
6DO2
6DWS
5E84
5E85
5E86
5F0X

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	HSPA5	480726	F1PIC7		Canis lupus familiaris	Prediction	More>>
1:1 ortholog	HSPA5	102185663	M4NBE4		Capra hircus	Prediction	More>>
1:1 ortholog	HSPA5	3309	P11021		Homo sapiens	Prediction	More>>
1:1 ortholog	Hspa5	14828	P20029	CPO	Mus musculus	Publication	More>>
1:1 ortholog	HSPA5	464733	H2PYQ3		Pan troglodytes	Prediction	More>>
1:1 ortholog		407060	A0A480UES1		Sus scrofa	Prediction	More>>
1:1 ortholog	Hspa5	25617	P06761		Rattus norvegicus	Prediction	More>>
1:1 ortholog	hspa5		Q6P3L3		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs373628096	p.Lys2Met	missense variant	-	NC_000009.12:g.125241122T>A	ESP,ExAC,TOPMed,gnomAD
rs918826597	p.Lys2Gln	missense variant	-	NC_000009.12:g.125241123T>G	TOPMed
rs774479903	p.Ser4Phe	missense variant	-	NC_000009.12:g.125241116G>A	ExAC,TOPMed,gnomAD
rs1235678444	p.Leu5Val	missense variant	-	NC_000009.12:g.125241114G>C	TOPMed
rs1279993952	p.Leu5Pro	missense variant	-	NC_000009.12:g.125241113A>G	TOPMed
rs1168692147	p.Leu10Pro	missense variant	-	NC_000009.12:g.125241098A>G	gnomAD
rs1452694680	p.Leu13Pro	missense variant	-	NC_000009.12:g.125241089A>G	gnomAD
rs781032276	p.Ser14Arg	missense variant	-	NC_000009.12:g.125241085G>C	ExAC,TOPMed,gnomAD
rs1179512258	p.Ala15Val	missense variant	-	NC_000009.12:g.125241083G>A	gnomAD
rs756929764	p.Ala16Val	missense variant	-	NC_000009.12:g.125241080G>A	ExAC,gnomAD
rs1202257346	p.Arg17Gln	missense variant	-	NC_000009.12:g.125241077C>T	gnomAD
rs980600790	p.Glu21Lys	missense variant	-	NC_000009.12:g.125241066C>T	TOPMed
rs758001741	p.Asp22Asn	missense variant	-	NC_000009.12:g.125241063C>T	ExAC,TOPMed,gnomAD
rs752211105	p.Asp22Gly	missense variant	-	NC_000009.12:g.125241062T>C	ExAC,TOPMed,gnomAD
rs766831759	p.Lys23Glu	missense variant	-	NC_000009.12:g.125241060T>C	ExAC,TOPMed,gnomAD
rs1223996848	p.Lys24Glu	missense variant	-	NC_000009.12:g.125241057T>C	TOPMed,gnomAD
rs1442272847	p.Asp26Glu	missense variant	-	NC_000009.12:g.125241049G>T	TOPMed
rs61999288	p.Asp26Asn	missense variant	-	NC_000009.12:g.125241051C>T	ExAC,TOPMed,gnomAD
rs750811646	p.Val27Met	missense variant	-	NC_000009.12:g.125241048C>T	ExAC,gnomAD
NCI-TCGA novel	p.Gly28Val	missense variant	-	NC_000009.12:g.125241044C>A	NCI-TCGA
NCI-TCGA novel	p.Gly28Ser	missense variant	-	NC_000009.12:g.125241045C>T	NCI-TCGA
rs1394566736	p.Thr29Met	missense variant	-	NC_000009.12:g.125241041G>A	gnomAD
NCI-TCGA novel	p.Leu35Met	missense variant	-	NC_000009.12:g.125241024G>T	NCI-TCGA
NCI-TCGA novel	p.Gly36Arg	missense variant	-	NC_000009.12:g.125241021C>T	NCI-TCGA
rs1231899934	p.Phe45Leu	missense variant	-	NC_000009.12:g.125240895G>C	gnomAD
rs1355193954	p.Lys46Ter	stop gained	-	NC_000009.12:g.125240894T>A	gnomAD
rs1237147765	p.Val50Met	missense variant	-	NC_000009.12:g.125240882C>T	TOPMed
NCI-TCGA novel	p.Glu51Ter	stop gained	-	NC_000009.12:g.125240879C>A	NCI-TCGA
NCI-TCGA novel	p.Ile52Thr	missense variant	-	NC_000009.12:g.125240875A>G	NCI-TCGA
NCI-TCGA novel	p.Pro63Gln	missense variant	-	NC_000009.12:g.125240842G>T	NCI-TCGA
rs377512653	p.Tyr65Cys	missense variant	-	NC_000009.12:g.125240836T>C	ESP,ExAC,TOPMed,gnomAD
rs377512653	p.Tyr65Phe	missense variant	-	NC_000009.12:g.125240836T>A	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Tyr65CysPheSerTerUnk	frameshift	-	NC_000009.12:g.125240835_125240836AT>-	NCI-TCGA
rs759479785	p.Val66Ile	missense variant	-	NC_000009.12:g.125240834C>T	ExAC,TOPMed
COSM4929070	p.Pro70Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125240822G>T	NCI-TCGA Cosmic
rs200897884	p.Pro70Ser	missense variant	-	NC_000009.12:g.125240822G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs746836983	p.Pro70Leu	missense variant	-	NC_000009.12:g.125240821G>A	ExAC,gnomAD
COSM3847651	p.Glu71Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125240819C>T	NCI-TCGA Cosmic
rs777686093	p.Glu73Gly	missense variant	-	NC_000009.12:g.125240812T>C	ExAC,gnomAD
NCI-TCGA novel	p.Asp78GluPheSerTerUnk	stop gained	-	NC_000009.12:g.125240796_125240797insGGTGTCAGGCGATTCTGGTCATTGGTGAT	NCI-TCGA
rs373292645	p.Glu89Lys	missense variant	-	NC_000009.12:g.125240765C>T	ESP,ExAC,TOPMed,gnomAD
rs754529165	p.Glu89Asp	missense variant	-	NC_000009.12:g.125240763C>A	ExAC,gnomAD
rs1187454921	p.Asn90Lys	missense variant	-	NC_000009.12:g.125240760G>T	gnomAD
COSM1105158	p.Val92Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125240756C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Arg97Trp	missense variant	-	NC_000009.12:g.125240741G>A	NCI-TCGA
rs757741308	p.Thr102Met	missense variant	-	NC_000009.12:g.125240725G>A	ExAC,TOPMed,gnomAD
rs764437821	p.Ser107Ala	missense variant	-	NC_000009.12:g.125240711A>C	ExAC,gnomAD
rs758699653	p.Gln110Glu	missense variant	-	NC_000009.12:g.125240702G>C	ExAC,TOPMed,gnomAD
rs201412581	p.Ile112Val	missense variant	-	NC_000009.12:g.125240696T>C	1000Genomes
rs1373246412	p.Lys113Asn	missense variant	-	NC_000009.12:g.125240691C>A	gnomAD
rs752980725	p.Pro116Gln	missense variant	-	NC_000009.12:g.125240683G>T	ExAC,gnomAD
NCI-TCGA novel	p.Val119Ala	missense variant	-	NC_000009.12:g.125240308A>G	NCI-TCGA
rs778199015	p.Val120Ala	missense variant	-	NC_000009.12:g.125240305A>G	ExAC,gnomAD
NCI-TCGA novel	p.Lys122Asn	missense variant	-	NC_000009.12:g.125240298C>A	NCI-TCGA
NCI-TCGA novel	p.Lys122Asn	missense variant	-	NC_000009.12:g.125240298C>G	NCI-TCGA
rs191087735	p.Ile132Thr	missense variant	-	NC_000009.12:g.125240269A>G	1000Genomes,ExAC,gnomAD
rs1364066030	p.Gly133Arg	missense variant	-	NC_000009.12:g.125240267C>T	gnomAD
rs1183495817	p.Gly135Arg	missense variant	-	NC_000009.12:g.125240261C>T	gnomAD
rs1417734683	p.Gln136His	missense variant	-	NC_000009.12:g.125240256T>A	gnomAD
rs765533290	p.Thr137Ile	missense variant	-	NC_000009.12:g.125240254G>A	ExAC,TOPMed
COSM3847649	p.Lys138Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125240250C>A	NCI-TCGA Cosmic
rs755130497	p.Thr139Lys	missense variant	-	NC_000009.12:g.125240248G>T	ExAC,gnomAD
rs755130497	p.Thr139Ile	missense variant	-	NC_000009.12:g.125240248G>A	ExAC,gnomAD
rs1212235788	p.Pro142Ser	missense variant	-	NC_000009.12:g.125240240G>A	gnomAD
rs1373860864	p.Glu144Gln	missense variant	-	NC_000009.12:g.125240234C>G	TOPMed
rs1278798103	p.Met148Val	missense variant	-	NC_000009.12:g.125240222T>C	TOPMed,gnomAD
rs1199995948	p.Thr151Asn	missense variant	-	NC_000009.12:g.125240212G>T	gnomAD
rs1351458297	p.Met153Ile	missense variant	-	NC_000009.12:g.125240205C>G	gnomAD
rs766559685	p.Glu155Lys	missense variant	-	NC_000009.12:g.125240201C>T	ExAC
rs760769294	p.Glu155Asp	missense variant	-	NC_000009.12:g.125240199T>G	ExAC,gnomAD
COSM3654336	p.Glu158Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125240192C>T	NCI-TCGA Cosmic
rs1287411884	p.Gly162Arg	missense variant	-	NC_000009.12:g.125240180C>T	gnomAD
rs1475987193	p.His167Pro	missense variant	-	NC_000009.12:g.125239526T>G	gnomAD
COSM1105157	p.Ala174Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125239506C>T	NCI-TCGA Cosmic
rs769398663	p.Ala187Ser	missense variant	-	NC_000009.12:g.125239467C>A	ExAC,gnomAD
rs1340057768	p.Gly188Arg	missense variant	-	NC_000009.12:g.125239464C>T	gnomAD
COSM1105156	p.Thr189Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125239461T>G	NCI-TCGA Cosmic
rs759090127	p.Thr189Asn	missense variant	-	NC_000009.12:g.125239460G>T	ExAC,gnomAD
rs759090127	p.Thr189Ile	missense variant	-	NC_000009.12:g.125239460G>A	ExAC,gnomAD
NCI-TCGA novel	p.Ala191Thr	missense variant	-	NC_000009.12:g.125239455C>T	NCI-TCGA
rs1389938825	p.Gly192Ser	missense variant	-	NC_000009.12:g.125239452C>T	TOPMed
rs1225600593	p.Val195Ile	missense variant	-	NC_000009.12:g.125239443C>T	gnomAD
rs1229759275	p.Met196Thr	missense variant	-	NC_000009.12:g.125239439A>G	gnomAD
rs776093278	p.Arg197Met	missense variant	-	NC_000009.12:g.125239436C>A	ExAC
rs748594236	p.Ile198Thr	missense variant	-	NC_000009.12:g.125239433A>G	ExAC
rs1175929824	p.Ile198Met	missense variant	-	NC_000009.12:g.125239432G>C	TOPMed
rs749620773	p.Asn200Lys	missense variant	-	NC_000009.12:g.125239426G>C	ExAC,TOPMed,gnomAD
rs779406868	p.Asn200Ser	missense variant	-	NC_000009.12:g.125239427T>C	ExAC,gnomAD
rs1465755612	p.Pro202Leu	missense variant	-	NC_000009.12:g.125239421G>A	TOPMed
NCI-TCGA novel	p.Gly210Asp	missense variant	-	NC_000009.12:g.125239308C>T	NCI-TCGA
COSM3904076	p.Leu211Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125239306G>T	NCI-TCGA Cosmic
rs777435502	p.Glu215Asp	missense variant	-	NC_000009.12:g.125239292C>A	ExAC,gnomAD
COSM5106644	p.Glu217ArgPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000009.12:g.125239288C>-	NCI-TCGA Cosmic
rs1443431270	p.Glu217Asp	missense variant	-	NC_000009.12:g.125239286C>A	gnomAD
rs1306743375	p.Asn219Ser	missense variant	-	NC_000009.12:g.125239281T>C	gnomAD
COSM4929196	p.Phe223Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125239270A>C	NCI-TCGA Cosmic
rs1429609324	p.Leu225Pro	missense variant	-	NC_000009.12:g.125239263A>G	gnomAD
NCI-TCGA novel	p.Asp231Asn	missense variant	-	NC_000009.12:g.125239246C>T	NCI-TCGA
rs746095580	p.Ile237Thr	missense variant	-	NC_000009.12:g.125239227A>G	ExAC,gnomAD
rs200482739	p.Asn239Ser	missense variant	-	NC_000009.12:g.125239221T>C	gnomAD
COSM1105155	p.Gly240Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125239218C>T	NCI-TCGA Cosmic
rs189604329	p.Asn248Ser	missense variant	-	NC_000009.12:g.125239194T>C	1000Genomes
rs752543561	p.Arg261His	missense variant	-	NC_000009.12:g.125239155C>T	ExAC,gnomAD
rs185877709	p.Arg261Cys	missense variant	-	NC_000009.12:g.125239156G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs765009153	p.Ile267Leu	missense variant	-	NC_000009.12:g.125239138T>G	ExAC,gnomAD
rs753498680	p.Thr274Met	missense variant	-	NC_000009.12:g.125239116G>A	ExAC,TOPMed,gnomAD
rs1217112485	p.Gly275Cys	missense variant	-	NC_000009.12:g.125239114C>A	TOPMed
rs1358602635	p.Asp277Ala	missense variant	-	NC_000009.12:g.125239107T>G	gnomAD
rs927584824	p.Asp277Tyr	missense variant	-	NC_000009.12:g.125239108C>A	gnomAD
rs1410032554	p.Arg283Lys	missense variant	-	NC_000009.12:g.125239089C>T	TOPMed,gnomAD
rs1415653914	p.Ala284Thr	missense variant	-	NC_000009.12:g.125239087C>T	gnomAD
rs201219378	p.Val285Ala	missense variant	-	NC_000009.12:g.125239083A>G	1000Genomes
COSM487041	p.Leu288Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125239075G>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Arg289Trp	missense variant	-	NC_000009.12:g.125239072G>A	NCI-TCGA
rs1183483292	p.Arg290His	missense variant	-	NC_000009.12:g.125239068C>T	TOPMed,gnomAD
rs1258181789	p.Arg290Cys	missense variant	-	NC_000009.12:g.125239069G>A	gnomAD
rs772745555	p.Glu291Lys	missense variant	-	NC_000009.12:g.125239066C>T	ExAC,gnomAD
rs772745555	p.Glu291Gln	missense variant	-	NC_000009.12:g.125239066C>G	ExAC,gnomAD
COSM5231001	p.Ala295ProPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000009.12:g.125239054C>-	NCI-TCGA Cosmic
NCI-TCGA novel	p.Lys296Thr	missense variant	-	NC_000009.12:g.125239050T>G	NCI-TCGA
rs764555947	p.Arg297Trp	missense variant	-	NC_000009.12:g.125239048G>A	ExAC,gnomAD
rs1179967296	p.Gln302Leu	missense variant	-	NC_000009.12:g.125239032T>A	gnomAD
rs763551125	p.Ala305Val	missense variant	-	NC_000009.12:g.125239023G>A	ExAC,gnomAD
rs776075958	p.Ile309Thr	missense variant	-	NC_000009.12:g.125239011A>G	ExAC,TOPMed,gnomAD
COSM752720	p.Phe312Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125239002A>G	NCI-TCGA Cosmic
rs545601947	p.Tyr313Cys	missense variant	-	NC_000009.12:g.125238999T>C	1000Genomes,ExAC,gnomAD
rs545601947	p.Tyr313Phe	missense variant	-	NC_000009.12:g.125238999T>A	1000Genomes,ExAC,gnomAD
rs1394745428	p.Glu316Gly	missense variant	-	NC_000009.12:g.125238990T>C	gnomAD
NCI-TCGA novel	p.Asp317Tyr	missense variant	-	NC_000009.12:g.125238988C>A	NCI-TCGA
rs746186875	p.Phe318Val	missense variant	-	NC_000009.12:g.125238985A>C	ExAC,TOPMed,gnomAD
rs776753213	p.Ser319Thr	missense variant	-	NC_000009.12:g.125238982A>T	ExAC,gnomAD
rs1432966367	p.Thr321Ile	missense variant	-	NC_000009.12:g.125238975G>A	gnomAD
rs762582529	p.Arg324Gln	missense variant	-	NC_000009.12:g.125238966C>T	-
rs747110106	p.Lys326Arg	missense variant	-	NC_000009.12:g.125238960T>C	ExAC,gnomAD
rs947809704	p.Glu329Asp	missense variant	-	NC_000009.12:g.125238950C>G	TOPMed
NCI-TCGA novel	p.Glu329Gln	missense variant	-	NC_000009.12:g.125238952C>G	NCI-TCGA
rs772811684	p.Met332Ile	missense variant	-	NC_000009.12:g.125238941C>T	ExAC,gnomAD
rs772811684	p.Met332Ile	missense variant	-	NC_000009.12:g.125238941C>G	ExAC,gnomAD
rs150434402	p.Met332Val	missense variant	-	NC_000009.12:g.125238943T>C	ESP,ExAC,TOPMed
rs1454496285	p.Asp333Ala	missense variant	-	NC_000009.12:g.125238826T>G	gnomAD
rs1252434461	p.Arg336Gln	missense variant	-	NC_000009.12:g.125238817C>T	gnomAD
rs1488339886	p.Arg336Trp	missense variant	-	NC_000009.12:g.125238818G>A	TOPMed,gnomAD
rs768548100	p.Thr338Ala	missense variant	-	NC_000009.12:g.125238812T>C	ExAC,gnomAD
rs1370988503	p.Met339Val	missense variant	-	NC_000009.12:g.125238809T>C	TOPMed
rs779884716	p.Lys340Arg	missense variant	-	NC_000009.12:g.125238805T>C	ExAC,gnomAD
rs779884716	p.Lys340Thr	missense variant	-	NC_000009.12:g.125238805T>G	ExAC,gnomAD
rs750103794	p.Val342Ile	missense variant	-	NC_000009.12:g.125238800C>T	ExAC,gnomAD
COSM74952	p.Gln343His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125238795C>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Gln343His	missense variant	-	NC_000009.12:g.125238795C>G	NCI-TCGA
rs1386517735	p.Glu347Lys	missense variant	-	NC_000009.12:g.125238785C>T	gnomAD
NCI-TCGA novel	p.Asp350Ala	missense variant	-	NC_000009.12:g.125238775T>G	NCI-TCGA
NCI-TCGA novel	p.Lys352Asn	missense variant	-	NC_000009.12:g.125238768C>A	NCI-TCGA
rs1368629912	p.Ser354Phe	missense variant	-	NC_000009.12:g.125238763G>A	gnomAD
NCI-TCGA novel	p.Asp355Asn	missense variant	-	NC_000009.12:g.125238761C>T	NCI-TCGA
rs760079687	p.Asp357Asn	missense variant	-	NC_000009.12:g.125238755C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Leu361His	missense variant	-	NC_000009.12:g.125238742A>T	NCI-TCGA
rs1343403693	p.Leu361Ile	missense variant	-	NC_000009.12:g.125238743G>T	TOPMed
rs1188284635	p.Pro369Ser	missense variant	-	NC_000009.12:g.125238719G>A	TOPMed
rs766767689	p.Lys370Glu	missense variant	-	NC_000009.12:g.125238716T>C	ExAC,gnomAD
rs1351604160	p.Gln372Glu	missense variant	-	NC_000009.12:g.125238710G>C	gnomAD
rs1482398176	p.Glu377Gln	missense variant	-	NC_000009.12:g.125238695C>G	gnomAD
rs772238271	p.Glu377Gly	missense variant	-	NC_000009.12:g.125238694T>C	ExAC,gnomAD
rs772238271	p.Glu377Val	missense variant	-	NC_000009.12:g.125238694T>A	ExAC,gnomAD
COSM752722	p.Asn380Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125238684A>T	NCI-TCGA Cosmic
rs761919160	p.Asn380Ser	missense variant	-	NC_000009.12:g.125238685T>C	ExAC,gnomAD
rs200135468	p.Lys382Arg	missense variant	-	NC_000009.12:g.125238679T>C	1000Genomes
COSM6182296	p.Ser385Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125238670G>C	NCI-TCGA Cosmic
rs774390329	p.Arg386His	missense variant	-	NC_000009.12:g.125238667C>T	ExAC,gnomAD
rs1330307450	p.Gly387Asp	missense variant	-	NC_000009.12:g.125238664C>T	gnomAD
rs768638015	p.Ile388Thr	missense variant	-	NC_000009.12:g.125238661A>G	ExAC,gnomAD
rs200526775	p.Ala393Thr	missense variant	-	NC_000009.12:g.125238647C>T	1000Genomes
COSM3654335	p.Ala395Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125238640G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Gly397Ser	missense variant	-	NC_000009.12:g.125238635C>T	NCI-TCGA
rs751174810	p.Asp408Asn	missense variant	-	NC_000009.12:g.125238602C>T	ExAC,gnomAD
COSM1105154	p.Asp410Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125238596C>A	NCI-TCGA Cosmic
rs568812325	p.Asp413Glu	missense variant	-	NC_000009.12:g.125238304G>T	1000Genomes,ExAC,gnomAD
COSM6114666	p.Leu417Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125238294G>A	NCI-TCGA Cosmic
rs757549614	p.Val419Ile	missense variant	-	NC_000009.12:g.125238288C>T	ExAC,gnomAD
rs1356972308	p.Leu422Val	missense variant	-	NC_000009.12:g.125238279G>C	TOPMed
COSM71109	p.Ile426Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125238267T>A	NCI-TCGA Cosmic
rs1282333876	p.Ile426Val	missense variant	-	NC_000009.12:g.125238267T>C	gnomAD
rs1265027435	p.Val432Ile	missense variant	-	NC_000009.12:g.125238249C>T	TOPMed
rs1267765504	p.Met433Val	missense variant	-	NC_000009.12:g.125238246T>C	gnomAD
rs751803191	p.Lys435Arg	missense variant	-	NC_000009.12:g.125238239T>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro438Gln	missense variant	-	NC_000009.12:g.125238230G>T	NCI-TCGA
NCI-TCGA novel	p.Pro438Leu	missense variant	-	NC_000009.12:g.125238230G>A	NCI-TCGA
NCI-TCGA novel	p.Pro438Ser	missense variant	-	NC_000009.12:g.125238231G>A	NCI-TCGA
rs763135186	p.Val443Met	missense variant	-	NC_000009.12:g.125238216C>T	ExAC,gnomAD
rs1324691272	p.Thr445Ser	missense variant	-	NC_000009.12:g.125238210T>A	gnomAD
NCI-TCGA novel	p.Lys446Asn	missense variant	-	NC_000009.12:g.125238205C>A	NCI-TCGA
rs775411427	p.Gln449His	missense variant	-	NC_000009.12:g.125238196C>A	ExAC,gnomAD
COSM3654334	p.Asn457Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125238172A>T	NCI-TCGA Cosmic
rs535209940	p.Asn457Tyr	missense variant	-	NC_000009.12:g.125238174T>A	1000Genomes,ExAC,gnomAD
rs1253850727	p.Pro459Ser	missense variant	-	NC_000009.12:g.125238168G>A	gnomAD
NCI-TCGA novel	p.Val461Ala	missense variant	-	NC_000009.12:g.125238161A>G	NCI-TCGA
rs772946608	p.Ile463Asn	missense variant	-	NC_000009.12:g.125238155A>T	ExAC,gnomAD
rs200465691	p.Ile463Val	missense variant	-	NC_000009.12:g.125238156T>C	1000Genomes,ExAC,gnomAD
rs761365893	p.Pro471Thr	missense variant	-	NC_000009.12:g.125237146G>T	ExAC,gnomAD
rs1472776693	p.Lys474Arg	missense variant	-	NC_000009.12:g.125237136T>C	gnomAD
rs936657160	p.His477Asn	missense variant	-	NC_000009.12:g.125237128G>T	TOPMed
NCI-TCGA novel	p.Leu478Pro	missense variant	-	NC_000009.12:g.125237124A>G	NCI-TCGA
NCI-TCGA novel	p.Thr481Ala	missense variant	-	NC_000009.12:g.125237116T>C	NCI-TCGA
rs1253923916	p.Asp483Gly	missense variant	-	NC_000009.12:g.125237109T>C	gnomAD
rs773987528	p.Thr485Ala	missense variant	-	NC_000009.12:g.125237104T>C	ExAC,gnomAD
rs1308682564	p.Ile487Val	missense variant	-	NC_000009.12:g.125237098T>C	TOPMed
rs1007136118	p.Pro491Leu	missense variant	-	NC_000009.12:g.125237085G>A	TOPMed
rs925239059	p.Val494Ala	missense variant	-	NC_000009.12:g.125237076A>G	TOPMed
rs1211616268	p.Gln496His	missense variant	-	NC_000009.12:g.125237069C>G	gnomAD
NCI-TCGA novel	p.Gln496His	missense variant	-	NC_000009.12:g.125237069C>A	NCI-TCGA
NCI-TCGA novel	p.Glu502Gln	missense variant	-	NC_000009.12:g.125237053C>G	NCI-TCGA
NCI-TCGA novel	p.Asp504Tyr	missense variant	-	NC_000009.12:g.125237047C>A	NCI-TCGA
NCI-TCGA novel	p.Gly507Asp	missense variant	-	NC_000009.12:g.125237037C>T	NCI-TCGA
rs1032511460	p.Arg510Gln	missense variant	-	NC_000009.12:g.125237028C>T	gnomAD
COSM3847648	p.Glu514Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125237017C>G	NCI-TCGA Cosmic
COSM1314449	p.Asp515His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125237014C>G	NCI-TCGA Cosmic
COSM5161920	p.Asn522IlePheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000009.12:g.125236992T>-	NCI-TCGA Cosmic
rs533357661	p.Lys523Arg	missense variant	-	NC_000009.12:g.125236989T>C	1000Genomes
rs1445882658	p.Ile526Val	missense variant	-	NC_000009.12:g.125236981T>C	gnomAD
rs1321415640	p.Asn528Ser	missense variant	-	NC_000009.12:g.125236974T>C	gnomAD
rs747433993	p.Asn528Asp	missense variant	-	NC_000009.12:g.125236975T>C	ExAC,TOPMed,gnomAD
rs758725284	p.Asp529Ala	missense variant	-	NC_000009.12:g.125236971T>G	ExAC,gnomAD
rs777998455	p.Asp529Asn	missense variant	-	NC_000009.12:g.125236972C>T	ExAC,gnomAD
rs779151361	p.Asn531Thr	missense variant	-	NC_000009.12:g.125236965T>G	ExAC,gnomAD
rs755135095	p.Arg532Cys	missense variant	-	NC_000009.12:g.125236963G>A	ExAC,TOPMed,gnomAD
rs368840257	p.Arg532His	missense variant	-	NC_000009.12:g.125236962C>T	ESP,TOPMed,gnomAD
rs368840257	p.Arg532Leu	missense variant	-	NC_000009.12:g.125236962C>A	ESP,TOPMed,gnomAD
rs753935146	p.Pro535Leu	missense variant	-	NC_000009.12:g.125236953G>A	ExAC,gnomAD
NCI-TCGA novel	p.Glu536Lys	missense variant	-	NC_000009.12:g.125236951C>T	NCI-TCGA
COSM3432860	p.Glu537Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000009.12:g.125236948C>A	NCI-TCGA Cosmic
rs191957514	p.Arg540Ser	missense variant	-	NC_000009.12:g.125236937C>G	1000Genomes,TOPMed,gnomAD
rs35356639	p.Asn543Asp	missense variant	-	NC_000009.12:g.125236930T>C	TOPMed,gnomAD
rs35356639	p.Asn543His	missense variant	-	NC_000009.12:g.125236930T>G	TOPMed,gnomAD
NCI-TCGA novel	p.Asp544Tyr	missense variant	-	NC_000009.12:g.125236927C>A	NCI-TCGA
NCI-TCGA novel	p.Glu546Lys	missense variant	-	NC_000009.12:g.125236921C>T	NCI-TCGA
rs750297913	p.Glu551Ter	stop gained	-	NC_000009.12:g.125236906C>A	ExAC,gnomAD
rs56136100	p.Glu557Gly	missense variant	-	NC_000009.12:g.125236887T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs771497933	p.Arg558Leu	missense variant	-	NC_000009.12:g.125236884C>A	ExAC,TOPMed,gnomAD
rs762500054	p.Arg558Cys	missense variant	-	NC_000009.12:g.125236885G>A	ExAC,TOPMed,gnomAD
rs771497933	p.Arg558His	missense variant	-	NC_000009.12:g.125236884C>T	ExAC,TOPMed,gnomAD
rs1189961861	p.Ile559Thr	missense variant	-	NC_000009.12:g.125236881A>G	TOPMed,gnomAD
NCI-TCGA novel	p.Asp560His	missense variant	-	NC_000009.12:g.125236879C>G	NCI-TCGA
rs144050975	p.Thr561Asn	missense variant	-	NC_000009.12:g.125236875G>T	ESP,ExAC,TOPMed,gnomAD
rs144050975	p.Thr561Ile	missense variant	-	NC_000009.12:g.125236875G>A	ESP,ExAC,TOPMed,gnomAD
rs1421568498	p.Thr561Ala	missense variant	-	NC_000009.12:g.125236876T>C	gnomAD
rs1188810256	p.Glu564Lys	missense variant	-	NC_000009.12:g.125236867C>T	gnomAD
rs541632037	p.Glu564Asp	missense variant	-	NC_000009.12:g.125236865C>A	1000Genomes,ExAC,gnomAD
rs1334409215	p.Tyr568Asp	missense variant	-	NC_000009.12:g.125236855A>C	TOPMed
COSM5145736	p.Ser571Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125236845G>T	NCI-TCGA Cosmic
COSM1105152	p.Lys573Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125236838C>A	NCI-TCGA Cosmic
rs1294335824	p.Ile576Phe	missense variant	-	NC_000009.12:g.125236831T>A	TOPMed
NCI-TCGA novel	p.Glu580Lys	missense variant	-	NC_000009.12:g.125236819C>T	NCI-TCGA
rs755226649	p.Leu582Gln	missense variant	-	NC_000009.12:g.125236812A>T	ExAC,gnomAD
rs1321198633	p.Ser587Thr	missense variant	-	NC_000009.12:g.125236798A>T	gnomAD
rs572560070	p.Glu589Lys	missense variant	-	NC_000009.12:g.125236792C>T	1000Genomes,ExAC,gnomAD
rs1363355640	p.Lys591Gln	missense variant	-	NC_000009.12:g.125236786T>G	TOPMed,gnomAD
rs552650805	p.Lys596Glu	missense variant	-	NC_000009.12:g.125236771T>C	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Val598Ile	missense variant	-	NC_000009.12:g.125236765C>T	NCI-TCGA
rs756195128	p.Glu600Gly	missense variant	-	NC_000009.12:g.125236758T>C	ExAC,TOPMed,gnomAD
rs143920039	p.Lys601Met	missense variant	-	NC_000009.12:g.125236755T>A	1000Genomes,ExAC,TOPMed,gnomAD
rs143920039	p.Lys601Thr	missense variant	-	NC_000009.12:g.125236755T>G	1000Genomes,ExAC,TOPMed,gnomAD
rs767440147	p.Ile602Thr	missense variant	-	NC_000009.12:g.125236752A>G	ExAC,TOPMed,gnomAD
rs898175617	p.Trp604Ter	stop gained	-	NC_000009.12:g.125236745C>T	TOPMed
rs375391643	p.Leu605Val	missense variant	-	NC_000009.12:g.125236744G>C	ESP,ExAC,TOPMed,gnomAD
rs1005567551	p.Asp610Glu	missense variant	-	NC_000009.12:g.125236727A>T	TOPMed
NCI-TCGA novel	p.Asp610Asn	missense variant	-	NC_000009.12:g.125236729C>T	NCI-TCGA
rs1191963130	p.Ile613Val	missense variant	-	NC_000009.12:g.125236720T>C	TOPMed,gnomAD
COSM1330732	p.Glu614Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125236715T>A	NCI-TCGA Cosmic
rs570413832	p.Glu614Lys	missense variant	-	NC_000009.12:g.125236717C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs368193721	p.Asp615Val	missense variant	-	NC_000009.12:g.125236713T>A	ESP,ExAC,TOPMed,gnomAD
COSM1460009	p.Phe616Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125236711A>G	NCI-TCGA Cosmic
rs775060069	p.Phe616Leu	missense variant	-	NC_000009.12:g.125236709G>C	ExAC,gnomAD
rs374062060	p.Ala618Thr	missense variant	-	NC_000009.12:g.125236705C>T	ESP,ExAC,TOPMed,gnomAD
rs1275953631	p.Ala618Asp	missense variant	-	NC_000009.12:g.125236704G>T	gnomAD
rs139238747	p.Lys619Glu	missense variant	-	NC_000009.12:g.125236702T>C	ESP,TOPMed,gnomAD
NCI-TCGA novel	p.Lys621Asn	missense variant	-	NC_000009.12:g.125236694C>A	NCI-TCGA
rs773627521	p.Lys621Glu	missense variant	-	NC_000009.12:g.125236696T>C	ExAC,TOPMed,gnomAD
rs1167147446	p.Glu622Lys	missense variant	-	NC_000009.12:g.125236693C>T	-
rs1303224537	p.Ile626Thr	missense variant	-	NC_000009.12:g.125236680A>G	gnomAD
COSM3926168	p.Val627Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.125236678C>T	NCI-TCGA Cosmic
rs1384841821	p.Val627Phe	missense variant	-	NC_000009.12:g.125236678C>A	gnomAD
rs748506361	p.Pro629Ser	missense variant	-	NC_000009.12:g.125236672G>A	ExAC,gnomAD
rs1411145997	p.Ser632Asn	missense variant	-	NC_000009.12:g.125236662C>T	gnomAD
rs769064758	p.Leu634Arg	missense variant	-	NC_000009.12:g.125236656A>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Leu634Ile	missense variant	-	NC_000009.12:g.125236657G>T	NCI-TCGA
NCI-TCGA novel	p.Gly636Glu	missense variant	-	NC_000009.12:g.125236650C>T	NCI-TCGA
rs1221171418	p.Gly636Ala	missense variant	-	NC_000009.12:g.125236650C>G	TOPMed
rs1378995475	p.Ser637Asn	missense variant	-	NC_000009.12:g.125236647C>T	gnomAD
rs756169862	p.Ala638Ser	missense variant	-	NC_000009.12:g.125236645C>A	ExAC,TOPMed,gnomAD
rs756169862	p.Ala638Thr	missense variant	-	NC_000009.12:g.125236645C>T	ExAC,TOPMed,gnomAD
rs538500528	p.Pro640Ala	missense variant	-	NC_000009.12:g.125236639G>C	1000Genomes,ExAC,gnomAD
rs538500528	p.Pro640Thr	missense variant	-	NC_000009.12:g.125236639G>T	1000Genomes,ExAC,gnomAD
rs781041888	p.Pro641Ala	missense variant	-	NC_000009.12:g.125236636G>C	ExAC,gnomAD
rs757206987	p.Pro642Thr	missense variant	-	NC_000009.12:g.125236633G>T	ExAC,TOPMed,gnomAD
rs1249822667	p.Pro642Gln	missense variant	-	NC_000009.12:g.125236632G>T	gnomAD
rs752372052	p.Glu646Asp	missense variant	-	NC_000009.12:g.125236619C>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu646Gln	missense variant	-	NC_000009.12:g.125236621C>G	NCI-TCGA
rs764834058	p.Asp652Glu	missense variant	-	NC_000009.12:g.125236601A>T	ExAC,TOPMed,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0001125	Acidosis, Lactic	phenotype	BEFREE
C0001418	Adenocarcinoma	group	BEFREE;LHGDN
C0001430	Adenoma	group	BEFREE
C0002395	Alzheimer's Disease	disease	BEFREE;LHGDN
C0002726	Amyloidosis	disease	BEFREE
C0003130	Anoxia	phenotype	LHGDN
C0003949	Asbestosis	disease	CTD_human
C0004114	Astrocytoma	disease	BEFREE
C0004238	Atrial Fibrillation	disease	BEFREE
C0005586	Bipolar Disorder	disease	BEFREE;LHGDN;PSYGENET
C0005695	Bladder Neoplasm	group	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0006413	Burkitt Lymphoma	disease	BEFREE
C0006826	Malignant Neoplasms	group	BEFREE
C0007102	Malignant tumor of colon	disease	BEFREE
C0007103	Malignant neoplasm of endometrium	disease	BEFREE
C0007113	Rectal Carcinoma	disease	BEFREE
C0007115	Malignant neoplasm of thyroid	disease	BEFREE
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE
C0007134	Renal Cell Carcinoma	disease	BEFREE
C0007137	Squamous cell carcinoma	disease	BEFREE
C0007138	Carcinoma, Transitional Cell	disease	BEFREE
C0007787	Transient Ischemic Attack	disease	RGD
C0008497	Choriocarcinoma	disease	BEFREE
C0009373	Colonic Diseases	group	BEFREE
C0009375	Colonic Neoplasms	group	BEFREE
C0009402	Colorectal Carcinoma	disease	BEFREE
C0009404	Colorectal Neoplasms	group	BEFREE
C0009691	Congenital cataract	disease	BEFREE
C0010054	Coronary Arteriosclerosis	disease	BEFREE
C0011311	Dengue Fever	disease	BEFREE
C0011847	Diabetes	disease	BEFREE
C0011849	Diabetes Mellitus	group	BEFREE
C0011854	Diabetes Mellitus, Insulin-Dependent	disease	BEFREE
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	disease	BEFREE
C0011881	Diabetic Nephropathy	disease	BEFREE
C0014057	Japanese Encephalitis	disease	BEFREE
C0015695	Fatty Liver	disease	BEFREE;RGD
C0015696	Fatty Liver, Alcoholic	disease	RGD
C0016057	Fibrosarcoma	disease	BEFREE
C0016169	pathologic fistula	phenotype	BEFREE
C0016412	Folic Acid Deficiency	disease	BEFREE
C0017636	Glioblastoma	disease	BEFREE
C0017638	Glioma	disease	BEFREE;LHGDN
C0017658	Glomerulonephritis	disease	BEFREE
C0018790	Cardiac Arrest	disease	BEFREE
C0019163	Hepatitis B	disease	BEFREE;LHGDN
C0019196	Hepatitis C	disease	BEFREE
C0020217	Hydatidiform Mole	disease	BEFREE
C0020456	Hyperglycemia	disease	BEFREE
C0023418	leukemia	disease	BEFREE
C0023434	Chronic Lymphocytic Leukemia	disease	BEFREE
C0023449	Acute lymphocytic leukemia	disease	BEFREE
C0023473	Myeloid Leukemia, Chronic	disease	CTD_human
C0023890	Liver Cirrhosis	disease	BEFREE
C0023896	Alcoholic Liver Diseases	group	BEFREE
C0023903	Liver neoplasms	group	BEFREE
C0024121	Lung Neoplasms	group	LHGDN
C0024299	Lymphoma	group	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0024814	Marinesco-Sjogren syndrome	disease	BEFREE
C0025202	melanoma	disease	BEFREE;LHGDN
C0026764	Multiple Myeloma	disease	BEFREE
C0026848	Myopathy	group	BEFREE
C0026896	Myasthenia Gravis	disease	BEFREE
C0027051	Myocardial Infarction	disease	CTD_human
C0027121	Myositis	disease	BEFREE
C0027627	Neoplasm Metastasis	phenotype	BEFREE;LHGDN
C0027651	Neoplasms	group	BEFREE
C0027819	Neuroblastoma	group	BEFREE;LHGDN
C0028754	Obesity	disease	BEFREE;CTD_human
C0029408	Degenerative polyarthritis	disease	BEFREE;LHGDN
C0029463	Osteosarcoma	disease	BEFREE
C0029925	Ovarian Carcinoma	disease	BEFREE
C0030297	Pancreatic Neoplasm	disease	LHGDN
C0030567	Parkinson Disease	disease	BEFREE
C0032285	Pneumonia	disease	BEFREE
C0032580	Adenomatous Polyposis Coli	disease	BEFREE
C0032962	Pregnancy Complications	group	BEFREE
C0033578	Prostatic Neoplasms	group	LHGDN
C0035228	Respiratory Hypersensitivity	phenotype	CTD_human
C0036341	Schizophrenia	disease	LHGDN
C0037952	Spinocerebellar Degeneration	group	LHGDN
C0038013	Ankylosing spondylitis	disease	LHGDN
C0038356	Stomach Neoplasms	group	BEFREE;LHGDN
C0040997	Trigeminal Neuralgia	disease	BEFREE
C0042133	Uterine Fibroids	group	BEFREE
C0042769	Virus Diseases	group	BEFREE
C0079731	B-Cell Lymphomas	group	BEFREE
C0087012	Ataxia, Spinocerebellar	disease	BEFREE
C0149521	Pancreatitis, Chronic	disease	BEFREE
C0149925	Small cell carcinoma of lung	disease	BEFREE
C0151744	Myocardial Ischemia	disease	BEFREE
C0155728	Other specified transient cerebral ischemias	disease	RGD
C0162309	Adrenoleukodystrophy	disease	BEFREE
C0162529	Colitis, Ischemic	disease	BEFREE
C0178874	Tumor Progression	phenotype	BEFREE
C0206624	Hepatoblastoma	disease	BEFREE
C0206698	Cholangiocarcinoma	disease	BEFREE
C0206717	Olfactory Neuroblastoma	disease	BEFREE
C0220668	Congenital contractural arachnodactyly	disease	BEFREE
C0235618	Proliferative glomerulonephritis	disease	BEFREE
C0235974	Pancreatic carcinoma	disease	BEFREE
C0239946	Fibrosis, Liver	disease	BEFREE
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0262404	Cerebellar degeneration	disease	BEFREE
C0263361	Psoriasis vulgaris	disease	BEFREE
C0268113	Familial juvenile gout	disease	BEFREE
C0268353	Cutis laxa, x-linked	disease	BEFREE
C0268494	Oculocutaneous albinism type 1	disease	BEFREE
C0270549	Generalized Anxiety Disorder	disease	BEFREE
C0270824	Visual seizure	disease	RGD
C0277524	Infectious colitis	disease	BEFREE
C0278620	refractory plasma cell neoplasm	disease	BEFREE
C0278701	Gastric Adenocarcinoma	disease	BEFREE
C0278878	Adult Glioblastoma	disease	BEFREE
C0278883	Metastatic melanoma	disease	BEFREE
C0278996	Malignant Head and Neck Neoplasm	disease	BEFREE
C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	disease	BEFREE
C0279626	Squamous cell carcinoma of esophagus	disease	BEFREE;CTD_human
C0280100	Solid Neoplasm	phenotype	BEFREE
C0280474	Childhood Glioblastoma	disease	BEFREE
C0282687	Hemorrhagic Fever, Ebola	disease	BEFREE
C0334277	Adenocarcinoma, metastatic	disease	BEFREE
C0334634	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	disease	BEFREE
C0338106	Adenocarcinoma of colon	disease	BEFREE
C0342793	Malonic aciduria	disease	BEFREE
C0345904	Malignant neoplasm of liver	disease	BEFREE
C0346647	Malignant neoplasm of pancreas	disease	BEFREE
C0362046	Prediabetes syndrome	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0376544	Hematopoietic Neoplasms	group	CTD_human
C0376545	Hematologic Neoplasms	group	CTD_human
C0398625	Protein C Deficiency	disease	BEFREE
C0400966	Non-alcoholic Fatty Liver Disease	disease	BEFREE
C0476089	Endometrial Carcinoma	disease	BEFREE
C0494165	Secondary malignant neoplasm of liver	disease	BEFREE
C0521158	Recurrent tumor	phenotype	BEFREE
C0524620	Metabolic Syndrome X	disease	BEFREE
C0524851	Neurodegenerative Disorders	group	BEFREE
C0549473	Thyroid carcinoma	disease	BEFREE
C0555198	Malignant Glioma	disease	BEFREE
C0585442	Osteosarcoma of bone	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0598608	Hyperhomocysteinemia	disease	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0677932	Progressive Neoplastic Disease	phenotype	BEFREE
C0678213	Complete hydatidiform mole	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0684249	Carcinoma of lung	disease	BEFREE
C0685938	Malignant neoplasm of gastrointestinal tract	disease	BEFREE
C0686619	Secondary malignant neoplasm of lymph node	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0700095	Central neuroblastoma	disease	BEFREE
C0751783	Lafora Disease	disease	BEFREE
C0853193	Bipolar I disorder	disease	BEFREE;PSYGENET
C0863194	Hepatoma resectable	disease	BEFREE
C1134719	Invasive Ductal Breast Carcinoma	disease	BEFREE
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1168401	Squamous cell carcinoma of the head and neck	disease	BEFREE
C1306459	Primary malignant neoplasm	group	BEFREE
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1332166	Adenocarcinoma of the gastroesophageal junction	disease	BEFREE
C1332986	Childhood Osteosarcoma	disease	BEFREE
C1334953	Neuroblastic tumors	disease	BEFREE
C1335302	Pancreatic Ductal Adenocarcinoma	disease	BEFREE
C1458155	Mammary Neoplasms	group	BEFREE
C1512409	Hepatocarcinogenesis	disease	BEFREE
C1519670	Tumor Angiogenesis	phenotype	BEFREE
C1527249	Colorectal Cancer	disease	BEFREE
C1621958	Glioblastoma Multiforme	disease	BEFREE
C1623038	Cirrhosis	disease	BEFREE
C1636149	Macular dystrophy, corneal type 1	disease	BEFREE
C1846707	SPINOCEREBELLAR ATAXIA 17	disease	BEFREE;CTD_human
C1858680	Familial encephalopathy with neuroserpin inclusion bodies	disease	BEFREE
C1883486	Uterine Corpus Cancer	disease	BEFREE
C1956346	Coronary Artery Disease	disease	BEFREE
C2145472	Urothelial Carcinoma	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE;CTD_human;LHGDN
C2711227	Steatohepatitis	disease	BEFREE
C2930617	Pulmonary Fibrosis - from Asbestos Exposure	disease	CTD_human
C2931822	Nasopharyngeal carcinoma	disease	BEFREE
C2939420	Metastatic Neoplasm	phenotype	BEFREE
C3160718	PARKINSON DISEASE, LATE-ONSET	disease	BEFREE
C3539781	Progressive cGVHD	disease	BEFREE
C3539878	Triple Negative Breast Neoplasms	disease	BEFREE
C3714948	PACHYONYCHIA CONGENITA 3	disease	BEFREE
C3828416	Radiation Damage	disease	BEFREE
C3887486	Interstitial lung fibrosis	phenotype	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005509	calcium ion binding	TAS
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IBA
GO:0005524	ATP binding	IDA
GO:0016887	ATPase activity	ISS
GO:0016887	ATPase activity	IDA
GO:0016887	ATPase activity	IBA
GO:0019899	enzyme binding	IPI
GO:0019904	protein domain specific binding	IPI
GO:0031072	heat shock protein binding	IBA
GO:0031625	ubiquitin protein ligase binding	IPI
GO:0042623	ATPase activity, coupled	IBA
GO:0043022	ribosome binding	IEA
GO:0044183	protein folding chaperone	IBA
GO:0045296	cadherin binding	HDA
GO:0051082	unfolded protein binding	TAS
GO:0051082	unfolded protein binding	IBA
GO:0051087	chaperone binding	TAS
GO:0051787	misfolded protein binding	IDA
GO:0051787	misfolded protein binding	IBA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001554	luteolysis	IEA
GO:0006983	ER overload response	IEA
GO:0006986	response to unfolded protein	IBA
GO:0010976	positive regulation of neuron projection development	IEA
GO:0021589	cerebellum structural organization	IEA
GO:0021680	cerebellar Purkinje cell layer development	IEA
GO:0021762	substantia nigra development	HEP
GO:0030182	neuron differentiation	IEA
GO:0030335	positive regulation of cell migration	IMP
GO:0030433	ubiquitin-dependent ERAD pathway	TAS
GO:0030433	ubiquitin-dependent ERAD pathway	IBA
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0030968	endoplasmic reticulum unfolded protein response	TAS
GO:0030968	endoplasmic reticulum unfolded protein response	IBA
GO:0031204	posttranslational protein targeting to membrane, translocation	IMP
GO:0031333	negative regulation of protein-containing complex assembly	ISS
GO:0031398	positive regulation of protein ubiquitination	IEA
GO:0034620	cellular response to unfolded protein	IBA
GO:0034975	protein folding in endoplasmic reticulum	TAS
GO:0035437	maintenance of protein localization in endoplasmic reticulum	IMP
GO:0035690	cellular response to drug	IEA
GO:0036498	IRE1-mediated unfolded protein response	TAS
GO:0036499	PERK-mediated unfolded protein response	TAS
GO:0036500	ATF6-mediated unfolded protein response	TAS
GO:0042026	protein refolding	IBA
GO:0042149	cellular response to glucose starvation	IDA
GO:0042220	response to cocaine	IEA
GO:0043066	negative regulation of apoptotic process	IMP
GO:0043066	negative regulation of apoptotic process	TAS
GO:0051085	chaperone cofactor-dependent protein refolding	IBA
GO:0051402	neuron apoptotic process	IEA
GO:0060904	regulation of protein folding in endoplasmic reticulum	TAS
GO:0071236	cellular response to antibiotic	IEA
GO:0071277	cellular response to calcium ion	IEA
GO:0071287	cellular response to manganese ion	IEA
GO:0071320	cellular response to cAMP	IEA
GO:0071353	cellular response to interleukin-4	IEA
GO:0071480	cellular response to gamma radiation	IEA
GO:0097501	stress response to metal ion	IEA
GO:1901998	toxin transport	IEA
GO:1903891	regulation of ATF6-mediated unfolded protein response	TAS
GO:1903894	regulation of IRE1-mediated unfolded protein response	TAS
GO:1903895	negative regulation of IRE1-mediated unfolded protein response	ISS
GO:1903897	regulation of PERK-mediated unfolded protein response	TAS
GO:1904313	response to methamphetamine hydrochloride	IEA
GO:1990090	cellular response to nerve growth factor stimulus	IEA
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	TAS

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005634	nucleus	IMP
GO:0005634	nucleus	HDA
GO:0005634	nucleus	IBA
GO:0005737	cytoplasm	IBA
GO:0005737	cytoplasm	IDA
GO:0005739	mitochondrion	IDA
GO:0005783	endoplasmic reticulum	IMP
GO:0005783	endoplasmic reticulum	TAS
GO:0005783	endoplasmic reticulum	IDA
GO:0005788	endoplasmic reticulum lumen	IDA
GO:0005788	endoplasmic reticulum lumen	IBA
GO:0005788	endoplasmic reticulum lumen	TAS
GO:0005789	endoplasmic reticulum membrane	TAS
GO:0005790	smooth endoplasmic reticulum	IEA
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	IDA
GO:0005829	cytosol	IDA
GO:0005886	plasma membrane	IEA
GO:0005925	focal adhesion	HDA
GO:0009986	cell surface	IEA
GO:0016020	membrane	HDA
GO:0016020	membrane	IBA
GO:0030176	integral component of endoplasmic reticulum membrane	IDA
GO:0030496	midbody	IDA
GO:0032991	protein-containing complex	IDA
GO:0034663	endoplasmic reticulum chaperone complex	IDA
GO:0034663	endoplasmic reticulum chaperone complex	IBA
GO:0042470	melanosome	IEA
GO:0043231	intracellular membrane-bounded organelle	IDA
GO:0070062	extracellular exosome	HDA
GO:0008180	COP9 signalosome	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	IEA
R-HSA-114608	Platelet degranulation	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	TAS
R-HSA-3371556	Cellular response to heat stress	TAS
R-HSA-381033	ATF6 (ATF6-alpha) activates chaperones	TAS
R-HSA-381042	PERK regulates gene expression	TAS
R-HSA-381070	IRE1alpha activates chaperones	TAS
R-HSA-381119	Unfolded Protein Response (UPR)	TAS
R-HSA-381183	ATF6 (ATF6-alpha) activates chaperone genes	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	IEA
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	IEA
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	IEA
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	TAS
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	IEA

Drugs and compounds information

ID	Drug Name	Action	PubMed
C063159	1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole	1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]	28495616
C025603	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of HSPA5 protein]	28181380
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSPA5 protein]	25950987
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]	24802810
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester results in increased expression of HSPA5 mRNA	25324550
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester results in increased expression of HSPA5 protein	25324550
D014013	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	23892647
D019813	1,2-Dimethylhydrazine	1,2-Dimethylhydrazine results in increased expression of HSPA5 protein	29879413
D019813	1,2-Dimethylhydrazine	trans-3-(4'-hydroxyphenyl)-2-propenoic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of HSPA5 protein]	29879413
C049325	1,2-dithiol-3-thione	1,2-dithiol-3-thione results in increased expression of HSPA5 mRNA	15302862
C049325	1,2-dithiol-3-thione	1,2-dithiol-3-thione results in decreased expression of HSPA5 mRNA	19162173
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of HSPA5 mRNA	25596134
C046760	15-acetyldeoxynivalenol	15-acetyldeoxynivalenol results in decreased expression of HSPA5 mRNA	20682335
C560296	1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one	1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one results in increased expression of HSPA5 mRNA	21504179
C560296	1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one	1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one results in increased expression of HSPA5 protein	21504179
C118559	1-bromopropane	1-bromopropane results in increased expression of HSPA5 protein	27421776
C118559	1-bromopropane	1-bromopropane results in increased expression of HSPA5 protein	21925529
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	TXN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein]	24140863
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein	24140863; 28082123;
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein]	28082123
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein	24675778; 25073091;
D015655	1-Methyl-4-phenylpyridinium	chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]	25073091
D015655	1-Methyl-4-phenylpyridinium	TXN protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]	24140863
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 mRNA	16026605
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein	24140863; 28082123;
D015655	1-Methyl-4-phenylpyridinium	Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]	28082123
D015655	1-Methyl-4-phenylpyridinium	TXN protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]	24140863
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of HSPA5 mRNA	28329830
C032668	1-nitropyrene	1-nitropyrene results in increased expression of HSPA5 protein	19460413
C032668	1-nitropyrene	Dicumarol inhibits the reaction [1-nitropyrene results in increased expression of HSPA5 protein]	19460413
C586710	(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone	(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone results in increased expression of HSPA5 mRNA	30502353
C586710	(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone	Acetylcysteine inhibits the reaction [(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone results in increased expression of HSPA5 mRNA]	30502353
C586710	(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone	methyl-beta-cyclodextrin inhibits the reaction [(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone results in increased expression of HSPA5 mRNA]	30502353
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of HSPA5 mRNA]	25827057
C477694	2,2',4,4',5-brominated diphenyl ether	2,2',4,4',5-brominated diphenyl ether results in decreased expression of HSPA5 protein	18550172
C477694	2,2',4,4',5-brominated diphenyl ether	2,2',4,4',5-brominated diphenyl ether results in decreased expression of HSPA5 protein	19954255
C477694	2,2',4,4',5-brominated diphenyl ether	2,2',4,4',5-brominated diphenyl ether results in increased expression of HSPA5 protein	19954255
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSPA5 mRNA	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSPA5 protein	23954424
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of HSPA5 mRNA	19095052
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSPA5 mRNA	22543052
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ALB protein results in increased expression of HSPA5 mRNA]	23994741
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HSPA5 mRNA	19114083
C587734	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSPA5 protein]	25950987
C587734	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSPA5 mRNA	25950987
C587734	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSPA5 protein	25950987
C587734	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSPA5 protein]	25950987
C004762	2,4-dichlorophenol	2,4-dichlorophenol results in increased expression of HSPA5 mRNA	27853103
C004762	2,4-dichlorophenol	2,4-dichlorophenol results in increased expression of HSPA5 protein	27853103
C004762	2,4-dichlorophenol	2,4-dichlorophenol results in increased expression of HSPA5 mRNA	25160872; 27853103;
C004762	2,4-dichlorophenol	2,4-dichlorophenol results in increased expression of HSPA5 protein	25160872; 27853103;
C004762	2,4-dichlorophenol	tauroursodeoxycholic acid inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 mRNA]	27853103
C004762	2,4-dichlorophenol	tauroursodeoxycholic acid inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 protein]	25160872
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene results in increased expression of HSPA5 mRNA	11409192
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	19428936
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of HSPA5 protein	24898257
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPA5 mRNA	15215175
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate inhibits the reaction [Glucose results in increased expression of HSPA5 protein]	30076216
C492322	2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole	2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Cyclosporine results in increased expression of HSPA5 protein]	22155090
C017911	2-(methylamino)isobutyric acid	2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of HSPA5 mRNA]	22215663
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]	25341683
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane analog promotes the reaction [HSPA5 protein affects the expression of and affects the activity of MMP9 protein]	25794856
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane analog results in decreased expression of HSPA5 protein	25794856
C043247	3-acetyldeoxynivalenol	3-acetyldeoxynivalenol results in decreased expression of HSPA5 mRNA	20682335
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased metabolism of HSPA5 protein	21402099
C025946	3-methyladenine	3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]	28245985
D017878	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of HSPA5 protein]	29421517
C060456	4,5-dihydroxy-1,2-dithiane	4,5-dihydroxy-1,2-dithiane results in increased expression of HSPA5 mRNA	14610226
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of HSPA5 mRNA	19561079
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 mRNA]	22226148
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 protein]	22226148
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal analog binds to HSPA5	18232660
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA	24291486
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of HSPA5 protein	24291486
C027576	4-hydroxy-2-nonenal	Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA]	24291486
C587938	(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone	(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone results in increased expression of HSPA5 mRNA	30502353
C587938	(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone	Acetylcysteine inhibits the reaction [(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone results in increased expression of HSPA5 mRNA]	30502353
C587938	(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone	methyl-beta-cyclodextrin inhibits the reaction [(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone results in increased expression of HSPA5 mRNA]	30502353
C498826	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of HSPA5 mRNA	23883479
C498826	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	Arsenic Trioxide promotes the reaction [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of HSPA5 mRNA]	23883479
C121358	4-phenylbutylamine	4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of HSPA5 protein]	30394307
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]	20165829
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]	28245985
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]	28063906
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 mRNA]	27470132
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]	27470132
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of HSPA5 protein]	29981725
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]	23743301
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]	27816613
C075773	4-phenylbutyric acid	4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]	27816613
C075773	4-phenylbutyric acid	Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]	27816613
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	27638049
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of HSPA5 mRNA]	27578021
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of HSPA5 protein]	26804720
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]	30602124
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 protein]	30602124
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]	17459145
C075773	4-phenylbutyric acid	4-phenylbutyric acid results in decreased expression of HSPA5 protein	28698385
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 mRNA]	28844859
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 protein]	28844859
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of HSPA5 protein]	30980806
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HSPA5 protein]	27484784
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	28844859
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	28844859
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]	28844859
C075773	4-phenylbutyric acid	4-phenylbutyric acid results in decreased expression of HSPA5 protein	27484784; 28844859;
D042462	4-Quinolones	4-Quinolones analog inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 mRNA]	31022492
D042462	4-Quinolones	4-Quinolones analog inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]	31022492
D042462	4-Quinolones	4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 mRNA]	31022492
D042462	4-Quinolones	4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]	31022492
D042462	4-Quinolones	ATF6 protein modified form promotes the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]	31022492
D042462	4-Quinolones	salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]	31022492
D042462	4-Quinolones	XBP1 mRNA alternative form promotes the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]	31022492
C535075	4-tosylcyclonovobiocic acid	4-tosylcyclonovobiocic acid results in increased expression of HSPA5 protein	19118525
C477187	5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole	5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole affects the expression of HSPA5 mRNA	22745752
C057360	5-(N,N-hexamethylene)amiloride	5-(N,N-hexamethylene)amiloride affects the expression of HSPA5 mRNA	19302589
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of HSPA5 mRNA	28073004
C111855	6-formylindolo(3,2-b)carbazole	6-formylindolo(3,2-b)carbazole results in increased expression of HSPA5 mRNA	27709270
C111855	6-formylindolo(3,2-b)carbazole	6-formylindolo(3,2-b)carbazole results in increased expression of HSPA5 protein	27709270
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]	23743301
C121465	6-methyl-2-(phenylethynyl)pyridine	6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]	17303341
C535076	7-tosylcyclonovobiocic acid	7-tosylcyclonovobiocic acid results in increased expression of HSPA5 protein	19118525
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSPA5 mRNA	22079614
D015127	9,10-Dimethyl-1,2-benzanthracene	[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of HSPA5 protein	22248470
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene results in increased expression of HSPA5 protein	22248470
C496492	abrine	abrine results in decreased expression of HSPA5 mRNA	31054353
D000082	Acetaminophen	Acetaminophen results in increased expression of HSPA5 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of HSPA5 mRNA	15606129; 17562736;
D000082	Acetaminophen	Acetaminophen results in increased expression of HSPA5 protein	31524377
D000082	Acetaminophen	Guanabenz inhibits the reaction [Acetaminophen results in increased expression of HSPA5 protein]	31524377
D000111	Acetylcysteine	4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]	27816613
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone results in increased expression of HSPA5 mRNA]	30502353
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSPA5 protein]	25950987
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone results in increased expression of HSPA5 mRNA]	30502353
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of HSPA5 protein]]	26772155
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	26772155
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]	27784618
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Ethylmercury Compounds affects the expression of HSPA5 mRNA]	27511942
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of HSPA5 protein]	28754437
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]	31276663
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]	25341683
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]]	26772155
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Resveratrol results in increased expression of HSPA5 protein]	26772155
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]	27816613
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]	24802810
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]	27816613
D000111	Acetylcysteine	Acetylcysteine results in increased expression of HSPA5 protein	19722195
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 mRNA]	21533816
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	24157283
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]	20493918
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSPA5 protein]	25451595
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of HSPA5 protein]	31330229
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HSPA5 protein]	21911445
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	20493918
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA]	24291486
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	21145380
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of HSPA5 protein]	21198628
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]	28296042
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]	28296042
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 protein]	30633982
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HSPA5 protein]	27484784
D000111	Acetylcysteine	Acetylcysteine results in decreased expression of HSPA5 protein	27484784
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]	18086661
D000171	Acrolein	Acrolein results in increased expression of HSPA5 protein	18951912
D000171	Acrolein	Acrolein results in decreased expression of HSPA5 mRNA	28482051
D000171	Acrolein	Acrolein results in increased expression of HSPA5 mRNA	28119953
D000255	Adenosine Triphosphate	[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA	24149798
D000255	Adenosine Triphosphate	[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein	24149798
D000255	Adenosine Triphosphate	Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA]	24149798
D000255	Adenosine Triphosphate	Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein]	24149798
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HSPA5 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HSPA5 mRNA	19770486
C430898	AGN 194204	AGN 194204 results in decreased expression of HSPA5 mRNA	15302862
D000496	Alloxan	Alloxan results in increased expression of HSPA5 mRNA	30076216
C518327	aloe emodin	aloe emodin results in increased expression of HSPA5 mRNA	22210228
C518327	aloe emodin	aloe emodin results in increased expression of HSPA5 protein	22210228
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of HSPA5 protein	26597043
C557933	AMG 837	AMG 837 results in increased expression of HSPA5 mRNA	30243991
D000584	Amiloride	Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]	20015086
D000584	Amiloride	Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	20015086
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HSPA5 mRNA	16483693
C023650	aniline	aniline results in increased nitrosation of HSPA5 protein	21708182
D000841	Anisomycin	Anisomycin results in decreased expression of HSPA5 mRNA	25324550
D000841	Anisomycin	Anisomycin results in decreased expression of HSPA5 protein	25324550
D000968	Antimycin A	Antimycin A results in increased expression of HSPA5 protein	21337367
D047310	Apigenin	Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]	20493918
D047310	Apigenin	Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	20493918
D047310	Apigenin	Apigenin results in decreased expression of HSPA5 mRNA	22359648
C000228	aristolochic acid I	aristolochic acid I results in increased expression of HSPA5	22445861
D001151	Arsenic	Arsenic results in increased expression of HSPA5 protein	19818359
D001151	Arsenic	Arsenic results in decreased expression of HSPA5 protein	22552367
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of HSPA5 protein	29684096
D000077237	Arsenic Trioxide	Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of HSPA5 protein]]	26772155
D000077237	Arsenic Trioxide	Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	26772155
D000077237	Arsenic Trioxide	Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]]	26772155
D000077237	Arsenic Trioxide	Arsenic Trioxide promotes the reaction [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of HSPA5 mRNA]	23883479
D000077237	Arsenic Trioxide	Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of HSPA5 protein]	26772155
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of HSPA5 mRNA	24356939; 25424538;
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of HSPA5 mRNA	11678611; 19695276; 22959511; 23883479;
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of HSPA5 protein	19695276; 22959511; 26772155;
D000077237	Arsenic Trioxide	Atrazine promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 mRNA]	11678611
D000077237	Arsenic Trioxide	HSPA5 protein affects the susceptibility to Arsenic Trioxide	19695276
D000077237	Arsenic Trioxide	Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	26772155
D000077237	Arsenic Trioxide	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	23892647
D000077237	Arsenic Trioxide	4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	27638049
D000077237	Arsenic Trioxide	Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 mRNA]	21533816
D000077237	Arsenic Trioxide	Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	24157283
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of HSPA5 mRNA	21533816; 24157283;
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of HSPA5 protein	23892647; 24157283; 27461142; 27638049;
D000077237	Arsenic Trioxide	ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	27638049
D000077237	Arsenic Trioxide	HSPA5 mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]	24157283
D000077237	Arsenic Trioxide	HSPA5 mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of CASP7 protein]	24157283
D000077237	Arsenic Trioxide	HSPA5 mutant form inhibits the reaction [Arsenic Trioxide results in increased degradation of CASP12 protein]	24157283
D000077237	Arsenic Trioxide	Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	27638049
D000077237	Arsenic Trioxide	Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	23892647
D000077237	Arsenic Trioxide	Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	21145380
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of HSPA5 protein	21145380
C015001	arsenite	arsenite results in increased expression of HSPA5 protein	22959463; 26677073;
C015001	arsenite	2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of HSPA5 mRNA]	22215663
C015001	arsenite	arsenite results in decreased expression of HSPA5 mRNA	18929588
C015001	arsenite	arsenite results in increased expression of HSPA5 mRNA	22215663
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of HSPA5 mRNA]	18929588
D017639	Asbestos, Amosite	Asbestos, Amosite results in increased expression of HSPA5 mRNA	23885834
D017639	Asbestos, Amosite	Asbestos, Amosite results in increased expression of HSPA5 protein	23885834
D017636	Asbestos, Amphibole	Asbestos, Amphibole results in decreased expression of HSPA5 protein	20855422
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in increased expression of HSPA5 protein	24918270
D017638	Asbestos, Crocidolite	OGG1 protein mutant form promotes the reaction [Asbestos, Crocidolite results in increased expression of HSPA5 protein]	24918270
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in increased expression of HSPA5 mRNA	25324550
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in increased expression of HSPA5 protein	25324550
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Fenretinide results in increased expression of HSPA5 protein]	17353921
D001205	Ascorbic Acid	Ascorbic Acid results in decreased expression of HSPA5 mRNA	19197388
D001241	Aspirin	Aspirin results in decreased expression of HSPA5 mRNA	14976132
D001241	Aspirin	Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein]	20665602
D001280	Atrazine	Atrazine promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 mRNA]	11678611
D001280	Atrazine	Atrazine results in decreased expression of HSPA5 mRNA	22378314
C550990	baicalein-7-O-diglucoside	baicalein-7-O-diglucoside results in decreased expression of HSPA5 mRNA	26253462
C550990	baicalein-7-O-diglucoside	baicalein-7-O-diglucoside results in decreased expression of HSPA5 protein	26253462
C004456	beauvericin	[beauvericin co-treated with enniatins] results in decreased expression of HSPA5 mRNA	31100301
D001542	Benomyl	Acetylcysteine inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]	27784618
D001542	Benomyl	Benomyl results in increased expression of HSPA5 protein	27784618
D001542	Benomyl	MitoTEMPO inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]	27784618
D001554	Benzene	Benzene results in increased expression of HSPA5 protein	12183065
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HSPA5 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in increased expression of HSPA5 mRNA	24356939
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HSPA5 mRNA	21632981; 26238291;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HSPA5 mRNA	19770486; 21715664;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSPA5 mRNA	21569818; 22228805;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSPA5 protein	17915553
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSPA5 mRNA	22300585
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HSPA5 mRNA	17915553
D001564	Benzo(a)pyrene	Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of HSPA5 mRNA]	17915553
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA5 protein	19139269; 21692457;
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and affects the localization of HSPA5 protein	23226310
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA5 mRNA	23226310
D001622	Betaine	Betaine results in decreased expression of HSPA5 mRNA	22945834
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of HSPA5 mRNA	19737606
C099952	bifenthrin	bifenthrin results in increased expression of HSPA5 protein	16271832
D001663	Bilirubin	Bilirubin results in increased expression of HSPA5 mRNA	20196124; 27578021;
D001663	Bilirubin	Bilirubin results in increased expression of HSPA5 protein	27578021
D001663	Bilirubin	4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased expression of HSPA5 mRNA]	27578021
C109992	bis(isopropyl methyl)phosphonate	bis(isopropyl methyl)phosphonate results in increased expression of HSPA5 mRNA	27665771
C109992	bis(isopropyl methyl)phosphonate	bis(isopropyl methyl)phosphonate results in increased expression of HSPA5 protein	27665771
C006780	bisphenol A	bisphenol A affects the expression of HSPA5 mRNA	20170705; 30903817;
C006780	bisphenol A	[bisphenol A co-treated with ESR1 protein] results in increased expression of HSPA5 protein	19269315
C006780	bisphenol A	bisphenol A results in increased expression of HSPA5 mRNA	25333893; 25619500;
C006780	bisphenol A	bisphenol A results in decreased expression of HSPA5 protein	21705745
C006780	bisphenol A	bisphenol A results in increased expression of HSPA5 mRNA	12233820; 12732195; 16713995; 20807545; 28641223;
C006780	bisphenol A	bisphenol A results in increased expression of HSPA5 protein	28279065; 28641223;
C006780	bisphenol A	Glucose affects the reaction [bisphenol A results in decreased expression of HSPA5 protein]	21705745
C006780	bisphenol A	bisphenol A results in increased expression of HSPA5 mRNA	28938450
C006780	bisphenol A	bisphenol A affects the expression of HSPA5 protein	20189627
C006780	bisphenol A	bisphenol A affects the expression of HSPA5 mRNA	30903817
C006780	bisphenol A	bisphenol A results in decreased expression of HSPA5 mRNA	30816183
C006780	bisphenol A	bisphenol A results in increased expression of HSPA5 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of HSPA5 protein	22649256
C006780	bisphenol A	bisphenol A results in increased methylation of HSPA5 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of HSPA5 mRNA	22434021
D001761	Bleomycin	Bleomycin results in increased expression of HSPA5 protein	25933445
C032688	boric acid	boric acid results in increased expression of HSPA5 mRNA	27587023
C032688	boric acid	boric acid results in increased expression of HSPA5 protein	25425213; 27587023;
D000069286	Bortezomib	Bortezomib inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]	18723477
D000069286	Bortezomib	Bortezomib inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	16357177
D000069286	Bortezomib	Bortezomib promotes the reaction [gambogic acid results in increased expression of HSPA5 protein]	24291039
D000069286	Bortezomib	Bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein]	15141013
D000069286	Bortezomib	Bortezomib results in increased expression of HSPA5	21762082
D000069286	Bortezomib	Bortezomib results in increased expression of HSPA5 mRNA	20977926
D000069286	Bortezomib	Bortezomib results in increased expression of HSPA5 protein	15141013; 15509775; 16024631; 16357177; 18723477; 20110775; 20546536; 24291039;
D000069286	Bortezomib	gambogic acid promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]	24291039
D000069286	Bortezomib	geldanamycin promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]	15141013
D000069286	Bortezomib	HSPA5 results in decreased susceptibility to Bortezomib	20546536
D000069286	Bortezomib	MYC protein promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]	18641367
D000069286	Bortezomib	Bortezomib results in increased expression of HSPA5 mRNA	15509775
D020126	Brefeldin A	Bortezomib inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]	18723477
D020126	Brefeldin A	Brefeldin A results in increased expression of HSPA5 mRNA	12147617; 19428936;
D020126	Brefeldin A	Brefeldin A results in increased expression of HSPA5 protein	18723477; 19428936; 20626587; 27358234;
D020126	Brefeldin A	Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]	20493918
D020126	Brefeldin A	Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]	20493918
D020126	Brefeldin A	Brefeldin A results in increased expression of HSPA5 protein	20493918
D020126	Brefeldin A	Glutathione inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]	20493918
C016274	bromoacetate	bromoacetate results in increased expression of HSPA5 mRNA	19753638
C032036	bromobenzene	bromobenzene metabolite binds to HSPA5 protein	12018992
C032036	bromobenzene	bromobenzene results in decreased expression of HSPA5 mRNA	15056800
C032036	bromobenzene	bromobenzene results in increased expression of HSPA5 mRNA	12628495
C022777	bufalin	bufalin results in decreased expression of HSPA5 mRNA	27444971
D016642	Bupropion	Bupropion results in increased expression of HSPA5 protein	21354251
D002065	Buspirone	Buspirone results in decreased expression of HSPA5 mRNA	24136188
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of HSPA5 protein]	25341683
C026105	butylidenephthalide	butylidenephthalide results in increased expression of HSPA5 protein	23770345
C038091	butylparaben	butylparaben results in increased expression of HSPA5 protein	29319206
D002087	Butyrates	Butyrates results in decreased expression of HSPA5 mRNA	14674679
C584509	C646 compound	C646 compound results in increased expression of HSPA5 mRNA	26191083
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of HSPA5 mRNA	16122865
D002104	Cadmium	Cadmium affects the reaction [Tetrachlorodibenzodioxin affects the expression of HSPA5 protein]	29107029
D002104	Cadmium	Cadmium results in increased expression of HSPA5	25805271
D002104	Cadmium	Selenium inhibits the reaction [Cadmium results in increased expression of HSPA5]	25805271
D002104	Cadmium	Cadmium results in increased expression of HSPA5 mRNA	16020198; 21694771;
D002104	Cadmium	Cadmium results in increased expression of HSPA5 protein	20600546
D002104	Cadmium	Cadmium results in increased expression of HSPA5 mRNA	26135744
D002104	Cadmium	Cadmium results in increased expression of HSPA5 mRNA	16759985
D002104	Cadmium	Cadmium results in increased expression of HSPA5 protein	16759985
D002104	Cadmium	Cycloheximide inhibits the reaction [Cadmium results in increased expression of HSPA5 protein]	16759985
D002104	Cadmium	Dactinomycin inhibits the reaction [Cadmium results in increased expression of HSPA5 protein]	16759985
C028031	cadmium acetate	cadmium acetate results in increased expression of HSPA5 protein	29870746; 29883672; 30605698;
C028031	cadmium acetate	Chloroquine promotes the reaction [cadmium acetate results in increased expression of HSPA5 protein]	29870746
C028031	cadmium acetate	KN 93 inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]	29883672
C028031	cadmium acetate	Sirolimus inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]	29870746
C028031	cadmium acetate	Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]	30605698
C028031	cadmium acetate	U 0126 promotes the reaction [cadmium acetate results in increased expression of HSPA5 protein]	29870746
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSPA5 protein	20071421
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of HSPA5 mRNA	23828170
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of HSPA5 protein	24419708; 26220685;
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSPA5 mRNA	18560533; 30796460;
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSPA5 protein	21809093; 25374377;
D019256	Cadmium Chloride	FBXO6 protein inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]	25374377
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSPA5 mRNA	15081267; 17464326; 25409916;
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSPA5 protein	21325019; 21908765;
D019256	Cadmium Chloride	LL Z1640-2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]	15081267
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSPA5 mRNA	18636176
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSPA5 protein	9559875
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]	18086661
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of HSPA5 mRNA	20600546
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSPA5 mRNA	16759985; 17464326; 18086661; 20576581;
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HSPA5 protein	16759985; 17464326; 18086661;
D019256	Cadmium Chloride	Cadmium Chloride results in increased phosphorylation of HSPA5 protein	20600546
D019256	Cadmium Chloride	CAT inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]	18086661
D019256	Cadmium Chloride	Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]	16759985
D019256	Cadmium Chloride	Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]	16759985
D019256	Cadmium Chloride	HSPA5 results in decreased susceptibility to Cadmium Chloride	17464326; 20600546;
D019256	Cadmium Chloride	SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]	18086661
D019256	Cadmium Chloride	SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]	18086661
C037123	cadmium sulfate	cadmium sulfate results in increased expression of HSPA5 mRNA	12064557
C055494	caffeic acid phenethyl ester	[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA	28223344
C055494	caffeic acid phenethyl ester	GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA]	28223344
C055494	caffeic acid phenethyl ester	NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA]	28223344
D000001	Calcimycin	Calcimycin results in increased expression of HSPA5 mRNA	12147617; 19428936;
D000001	Calcimycin	Calcimycin results in increased expression of HSPA5 protein	19139269; 19428936; 27064126;
D000001	Calcimycin	Quercetin inhibits the reaction [Calcimycin results in increased expression of HSPA5 mRNA]	19428936
D000001	Calcimycin	Quercetin inhibits the reaction [Calcimycin results in increased expression of HSPA5 protein]	19428936
D000001	Calcimycin	Calcimycin results in increased expression of HSPA5 mRNA	14610226
D000001	Calcimycin	Calcimycin results in increased expression of HSPA5 protein	18799549
D000001	Calcimycin	Calcimycin results in increased expression of and affects the localization of HSPA5 protein	23226310
D000001	Calcimycin	Calcimycin results in increased expression of HSPA5 mRNA	23226310
D000001	Calcimycin	Calcimycin results in increased expression of HSPA5 protein	8818631
D002118	Calcium	[DNAJB11 protein binds to HSPA5 protein] which results in decreased transport of Calcium	26085089
D002118	Calcium	[DNAJC3 protein binds to HSPA5 protein] which results in decreased transport of Calcium	26085089
D002118	Calcium	[HSPA5 protein binds to SEC61A1 protein] which results in decreased transport of Calcium	26085089
D002118	Calcium	HSPA5 protein results in decreased transport of Calcium	26085089
D002118	Calcium	[HSPA5 protein results in decreased transport of Calcium] which results in increased susceptibility to Thapsigargin	26085089
C058076	calpain inhibitor III	calpain inhibitor III inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein]	19336499
C077793	candesartan cilexetil	candesartan cilexetil results in decreased expression of HSPA5 protein	22120037
D002193	Cantharidin	Cantharidin results in increased expression of HSPA5 protein	27113412
D002211	Capsaicin	Capsaicin results in increased expression of HSPA5	21859781
D002211	Capsaicin	Capsaicin results in increased expression of HSPA5 protein	19139269; 19699254;
D002211	Capsaicin	Capsaicin results in increased localization of HSPA5 protein	19331147
D012721	Carbaryl	Carbaryl results in increased expression of HSPA5 mRNA	11226373; 27829164;
D002251	Carbon Tetrachloride	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of HSPA5 mRNA]	25827057
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HSPA5 mRNA	25827057; 27339419;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HSPA5 protein	30538632
D002251	Carbon Tetrachloride	STF 083010 inhibits the reaction [Carbon Tetrachloride results in increased expression of HSPA5 protein]	30538632
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of HSPA5 mRNA	15963342
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HSPA5 mRNA	31150632
D002251	Carbon Tetrachloride	[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of HSPA5 mRNA	20097184
D002251	Carbon Tetrachloride	[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of HSPA5 protein	20097184
D002251	Carbon Tetrachloride	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HSPA5 mRNA]	31150632
D016190	Carboplatin	Carboplatin results in decreased expression of HSPA5 mRNA	18172885
C054133	casticin	casticin results in increased expression of HSPA5 protein	27862857
D000068579	Celecoxib	Celecoxib results in increased expression of HSPA5	21567098
D002108	Ceruletide	Ceruletide results in decreased expression of HSPA5 protein	18024178
C588229	chikusetsusaponin V	chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]	25073091
D007631	Chlordecone	[Chlordecone co-treated with Fulvestrant] results in increased expression of HSPA5 protein	17640991
D007631	Chlordecone	Chlordecone promotes the reaction [ESR1 protein binds to HSPA5 protein]	17640991
D007631	Chlordecone	Chlordecone results in increased expression of HSPA5 mRNA	17640991
D007631	Chlordecone	Chlordecone results in increased expression of HSPA5 protein	17640991
D007631	Chlordecone	ESR1 protein affects the reaction [HSPA5 protein results in increased susceptibility to Chlordecone]	17640991
D007631	Chlordecone	HSPA5 protein results in increased susceptibility to Chlordecone	17640991
D002710	Chlorhexidine	Chlorhexidine results in increased expression of HSPA5 protein	19027770
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of HSPA5 mRNA	18636392
C004656	chloroacetaldehyde	chloroacetaldehyde results in decreased expression of HSPA5 mRNA	25596134
C006972	chloroacetic acid	Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSPA5 protein]	25451595
C006972	chloroacetic acid	chloroacetic acid results in increased expression of HSPA5 mRNA	25451595
C006972	chloroacetic acid	chloroacetic acid results in increased expression of HSPA5 protein	25451595
C006972	chloroacetic acid	HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]	25451595
C006972	chloroacetic acid	HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]	25451595
C031294	chlorobenzene	chlorobenzene results in increased expression of HSPA5 protein	12183065
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of HSPA5 mRNA	23650126
C007020	chlorophyllin	chlorophyllin analog results in increased expression of HSPA5 protein	22852132
C100187	chloropicrin	chloropicrin results in increased expression of HSPA5 protein	22516760
D002738	Chloroquine	Chloroquine promotes the reaction [cadmium acetate results in increased expression of HSPA5 protein]	29870746
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of HSPA5 mRNA	25424538
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of HSPA5 protein	27993609
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of HSPA5 mRNA	22515965
D002784	Cholesterol	Cholesterol results in decreased expression of HSPA5 protein	17029598
D002794	Choline	Choline affects the expression of HSPA5 mRNA	17616785
D002794	Choline	[Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HSPA5 protein	23439872
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HSPA5 gene	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of HSPA5 protein	23038002
D002794	Choline	Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of HSPA5 protein]	23038002
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of HSPA5 protein	30416085
C074702	chromium hexavalent ion	[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of HSPA5 protein	30974164
D000077404	Cidofovir	Cidofovir results in decreased expression of HSPA5 mRNA	25596134
D002927	Cimetidine	Cimetidine inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]	27983966
D002945	Cisplatin	[Cisplatin co-treated with Quercetin] results in increased expression of HSPA5 mRNA	27514524
D002945	Cisplatin	Cisplatin results in decreased expression of HSPA5 mRNA	11099651; 25596134; 27594783;
D002945	Cisplatin	Cisplatin results in increased expression of HSPA5 mRNA	19561079
D002945	Cisplatin	Cisplatin results in increased expression of HSPA5 protein	16357177
D002945	Cisplatin	HSPA5 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]	27234046
D002945	Cisplatin	HSPA5 protein affects the reaction [Cisplatin results in increased cleavage of PARP1 protein]	27234046
D002945	Cisplatin	[Quercetin results in increased susceptibility to Cisplatin] which results in increased expression of HSPA5 protein	25611565
D002945	Cisplatin	Cisplatin results in decreased expression of HSPA5 mRNA	21151649
D002945	Cisplatin	Cisplatin affects the expression of HSPA5 protein	20071420
D002945	Cisplatin	Cisplatin results in increased expression of HSPA5 mRNA	23603837
D002945	Cisplatin	Cisplatin results in increased expression of HSPA5 protein	23603837
D002945	Cisplatin	Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of HSPA5 mRNA]	23603837
D002945	Cisplatin	Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of HSPA5 protein]	23603837
D002994	Clofibrate	Clofibrate results in decreased expression of HSPA5 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of HSPA5 mRNA	21318169
C018021	cobaltous chloride	cobaltous chloride results in increased expression of HSPA5 mRNA	24612858
C018021	cobaltous chloride	cobaltous chloride results in increased expression of HSPA5 protein	21337367
C018021	cobaltous chloride	cobaltous chloride results in increased expression of HSPA5 mRNA	17464326
D003042	Cocaine	Cocaine results in increased expression of HSPA5 mRNA	15009677
D003042	Cocaine	6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]	17303341
D003042	Cocaine	Cocaine results in increased expression of HSPA5 mRNA	23644055
D003042	Cocaine	Cocaine results in increased expression of HSPA5 protein	17303341
D003042	Cocaine	Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]	17303341
D003042	Cocaine	N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]	17303341
D003042	Cocaine	SCH 23390 inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]	17303341
D003078	Colchicine	Colchicine results in increased expression of HSPA5 protein	27358234
D005576	Colforsin	HSPA5 protein results in increased susceptibility to Colforsin	22912664
D003300	Copper	Copper results in increased expression of HSPA5 protein	15836927; 22692975;
D003300	Copper	HSPA5 protein binds to Copper	14534351; 15359738;
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of HSPA5 mRNA	20971185
D003300	Copper	Copper binds to HSPA5 protein	21815057
C464760	copper-1,10-phenanthroline	copper-1,10-phenanthroline results in increased expression of HSPA5 protein	24638265
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of HSPA5 mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate affects the localization of HSPA5 protein	21815057
D019327	Copper Sulfate	Copper Sulfate results in increased expression of HSPA5 mRNA	17464326
C029892	cupric chloride	cupric chloride results in increased expression of HSPA5 protein	21641295
C029892	cupric chloride	cupric chloride results in increased expression of HSPA5 protein	22699969
C029892	cupric chloride	[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 mRNA	20920558
C029892	cupric chloride	[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 protein	20920558
C029892	cupric chloride	pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 mRNA]	20920558
D003474	Curcumin	Curcumin inhibits the reaction [lead nitrate results in increased expression of HSPA5 protein]	20071421
D003474	Curcumin	Curcumin results in increased expression of HSPA5 mRNA	29723631
D003474	Curcumin	Curcumin results in increased expression of HSPA5 mRNA	18200517
D003513	Cycloheximide	Cycloheximide inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]	31276663
D003513	Cycloheximide	Cycloheximide inhibits the reaction [GIF 0010 results in increased expression of HSPA5 mRNA]	9742210
D003513	Cycloheximide	Cycloheximide inhibits the reaction [lead acetate results in increased expression of HSPA5 protein]	17915553
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 protein]	17915553
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]	16759985
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Cadmium results in increased expression of HSPA5 protein]	16759985
D003520	Cyclophosphamide	Cyclophosphamide metabolite results in increased expression of HSPA5 mRNA	24356939
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of HSPA5 mRNA	11906922
D016572	Cyclosporine	Cyclosporine results in increased expression of HSPA5 mRNA	19159671; 20106945; 21163907; 21632981; 24973091; 25562108; 25596134; 27989131;
D016572	Cyclosporine	Cyclosporine results in increased expression of HSPA5 protein	27358234
D016572	Cyclosporine	Cyclosporine results in increased expression of HSPA5 protein	15494209
D016572	Cyclosporine	2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Cyclosporine results in increased expression of HSPA5 protein]	22155090
D016572	Cyclosporine	Cyclosporine results in increased expression of HSPA5 mRNA	23308384; 25047351;
D016572	Cyclosporine	Cyclosporine results in increased expression of HSPA5 protein	22155090; 23308384; 25047351;
D016572	Cyclosporine	Cyclosporine results in increased expression of HSPA5 mRNA	25596134
D016572	Cyclosporine	Cyclosporine results in increased expression of HSPA5 protein	20136702
D016572	Cyclosporine	Melatonin promotes the reaction [Cyclosporine results in increased expression of HSPA5 protein]	20136702
C089595	cylindrospermopsin	cylindrospermopsin results in decreased expression of HSPA5 mRNA	24921660
C017160	cypermethrin	cypermethrin results in decreased expression of HSPA5 mRNA	25424538
C017160	cypermethrin	cypermethrin results in increased expression of HSPA5 protein	15494209
D003571	Cytochalasin B	Cytochalasin B results in increased expression of HSPA5 protein	26732598
D003603	Cytotoxins	Cytotoxins results in increased cleavage of HSPA5 protein	21147958
D003603	Cytotoxins	Cytotoxins results in increased expression of HSPA5 mRNA	21147958
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of HSPA5 mRNA]	17915553
D003609	Dactinomycin	Dactinomycin inhibits the reaction [lead acetate results in increased expression of HSPA5 mRNA]	17915553
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 mRNA]	17915553
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	17915553
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	17915553
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]	16759985
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Cadmium results in increased expression of HSPA5 protein]	16759985
C004315	danthron	danthron results in increased expression of HSPA5 protein	21126053
D003620	Dantrolene	Dantrolene inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]	23743301
D003634	DDT	DDT results in increased expression of HSPA5 mRNA	15710169
D003634	DDT	DDT results in increased expression of HSPA5 mRNA	29477483
C017180	decamethrin	decamethrin results in increased expression of HSPA5 protein	30247739
C017180	decamethrin	decamethrin results in increased expression of HSPA5 protein	25359175
C050229	demethoxycurcumin	demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	26264395
D003840	Deoxycholic Acid	HSPA5 protein results in decreased susceptibility to Deoxycholic Acid	12507930
D003847	Deoxyglucose	4-Quinolones analog inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 mRNA]	31022492
D003847	Deoxyglucose	4-Quinolones analog inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]	31022492
D003847	Deoxyglucose	ATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]	20593179
D003847	Deoxyglucose	Deoxyglucose results in increased expression of HSPA5 mRNA	31022492
D003847	Deoxyglucose	Deoxyglucose results in increased expression of HSPA5 protein	20593179; 31022492;
D003847	Deoxyglucose	HSPA5 protein affects the reaction [A2M protein modified form results in increased uptake of Deoxyglucose]	25720493
D003847	Deoxyglucose	HSPA5 protein affects the reaction [INS protein results in increased uptake of Deoxyglucose]	25720493
D003847	Deoxyglucose	Mannose inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]	20593179
D003847	Deoxyglucose	Oxygen deficiency inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]	20593179
D003847	Deoxyglucose	Deoxyglucose results in increased expression of HSPA5 protein	8818631
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of HSPA5 mRNA	20682335; 24356939;
C007262	deoxynivalenol	calpain inhibitor III inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein]	19336499
C007262	deoxynivalenol	deoxynivalenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 mRNA]	10652249
C007262	deoxynivalenol	deoxynivalenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 protein]	10652249
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of HSPA5 mRNA	10652249
C007262	deoxynivalenol	deoxynivalenol results in increased degradation of and results in decreased expression of HSPA5 protein	19336499
C007262	deoxynivalenol	deoxynivalenol results in increased phosphorylation of HSPA5 protein	23811945
C007262	deoxynivalenol	phenylalanyl-glycyl-NHO-Bz inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein]	19336499
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of HSPA5 protein	19550292
D003974	Diatrizoate Meglumine	Diatrizoate Meglumine results in increased expression of HSPA5 protein	20071420
D003976	Diazinon	Diazinon results in decreased expression of HSPA5 mRNA	24356939
D003976	Diazinon	Diazinon results in increased expression of HSPA5 protein	19647006
D003993	Dibutyl Phthalate	4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of HSPA5 protein]	26804720
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of HSPA5 protein	26804720
D004008	Diclofenac	Diclofenac results in increased expression of HSPA5 mRNA	27313093
D004008	Diclofenac	[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HSPA5 protein	25772430
D004008	Diclofenac	Diclofenac results in increased expression of HSPA5 mRNA	25014874
D001728	Dicumarol	Dicumarol inhibits the reaction [1-nitropyrene results in increased expression of HSPA5 protein]	19460413
C005406	dienochlor	dienochlor results in decreased expression of HSPA5 protein	16884889
D004041	Dietary Fats	[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA	28223344
D004041	Dietary Fats	Dietary Fats results in increased expression of HSPA5 protein	23038002; 23576437; 26655953;
D004041	Dietary Fats	GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA]	28223344
D004041	Dietary Fats	[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA	28223344
D004041	Dietary Fats	NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA]	28223344
D004041	Dietary Fats	obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]	26655953
D004041	Dietary Fats	[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of HSPA5 mRNA	22509299
D004041	Dietary Fats	[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of HSPA5 protein	22509299
D004041	Dietary Fats	[Streptozocin co-treated with Dietary Fats] results in increased expression of HSPA5 protein	26522834
D004041	Dietary Fats	Tamoxifen inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]	23038002
D004041	Dietary Fats	tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]	28223344
D004041	Dietary Fats	Dietary Fats results in increased expression of HSPA5 protein	26055348
D004041	Dietary Fats	Resveratrol inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]	26055348
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of HSPA5 mRNA	21318169
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of HSPA5 protein	16400681
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HSPA5 mRNA	21318169; 25280772;
C014476	diethyl maleate	diethyl maleate results in decreased reduction of HSPA5 protein	19843705
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPA5 mRNA	18544905
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of HSPA5 mRNA	11323195
C012906	dihydrocapsaicin	dihydrocapsaicin results in increased expression of HSPA5 protein	19139269
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of HSPA5 mRNA	29581250
C007420	dihydroxyaluminum aminoacetate	dihydroxyaluminum aminoacetate results in decreased expression of HSPA5 mRNA	21432213
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of HSPA5 mRNA	27638505
D004126	Dimethylformamide	[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of HSPA5 mRNA	20097184
D004126	Dimethylformamide	[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of HSPA5 protein	20097184
C019357	dioscin	dioscin inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]	24146112
D004147	Dioxins	Dioxins affects the expression of HSPA5 mRNA	20463971
D004229	Dithiothreitol	Dithiothreitol metabolite results in increased expression of HSPA5 protein	17416481
D004229	Dithiothreitol	Dithiothreitol results in increased expression of HSPA5 mRNA	15710169; 17332266;
D004229	Dithiothreitol	Dithiothreitol results in increased expression of HSPA5 protein	21692457
D004237	Diuron	Diuron results in decreased expression of HSPA5 mRNA	21551480
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]	17303341
D004298	Dopamine	Dopamine results in increased expression of HSPA5 protein	24675778
D004317	Doxorubicin	Doxorubicin affects the expression of HSPA5 protein	29385562
D004317	Doxorubicin	Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	16298333
D004317	Doxorubicin	Doxorubicin results in increased expression of HSPA5 mRNA	17680992; 29803840;
D004317	Doxorubicin	Doxorubicin results in increased expression of HSPA5 mRNA	30261314
D004317	Doxorubicin	1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]	28495616
D004317	Doxorubicin	Doxorubicin results in decreased expression of HSPA5 mRNA	30261314
D004317	Doxorubicin	Doxorubicin results in increased expression of HSPA5 protein	28495616
D004317	Doxorubicin	salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]	28495616
D013759	Dronabinol	Dronabinol results in decreased expression of HSPA5 mRNA	16039398
D013759	Dronabinol	Dronabinol results in increased expression of HSPA5 mRNA	31054322
D013759	Dronabinol	Dronabinol results in increased expression of HSPA5 protein	18163980; 31054322;
D013759	Dronabinol	[Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of HSPA5 mRNA]	31054322
D013759	Dronabinol	Dronabinol results in increased expression of HSPA5 mRNA	16616335
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal results in increased expression of HSPA5 protein	23239598; 23315830;
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]	27983966
D004391	Dust	Dust results in increased expression of HSPA5 mRNA	17805423
D004441	Ecdysterone	Ecdysterone results in decreased expression of HSPA5 protein	29126784
D004441	Ecdysterone	Ecdysterone results in increased expression of HSPA5 mRNA	29126784
D000077553	Edaravone	Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein]	21429313
D015777	Eicosanoids	Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of HSPA5 mRNA]	23603837
D015777	Eicosanoids	Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of HSPA5 protein]	23603837
D004642	Emodin	Emodin results in increased expression of HSPA5 protein	19549930
C007590	emulphogene BC 720	emulphogene BC 720 results in increased expression of HSPA5 mRNA	25398874
D004726	Endosulfan	Endosulfan results in increased expression of HSPA5 protein	16884889
D004726	Endosulfan	Endosulfan affects the expression of HSPA5 mRNA	29391264
C013525	ENNG	[ENNG co-treated with Isoflavones] results in increased expression of HSPA5 protein	22248470
C013525	ENNG	ENNG results in increased expression of HSPA5 protein	22248470
C100264	enniatins	[beauvericin co-treated with enniatins] results in decreased expression of HSPA5 mRNA	31100301
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HSPA5 protein	23301498
D004837	Epinephrine	[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein	19464573
D004958	Estradiol	Estradiol results in decreased expression of HSPA5 mRNA	24349563
D004958	Estradiol	[Estradiol co-treated with ESR1 protein] results in increased expression of HSPA5 protein	19269315
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in increased expression of HSPA5 mRNA	30165855
D004958	Estradiol	Estradiol results in decreased expression of HSPA5 mRNA	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of HSPA5 mRNA]	23094148
D004958	Estradiol	Estradiol results in increased expression of HSPA5 mRNA	14664709; 17640991;
D004958	Estradiol	Estradiol results in increased expression of HSPA5 protein	17640991
D000431	Ethanol	Ethanol results in increased expression of HSPA5 mRNA	29361514
D000431	Ethanol	sodium arsenite promotes the reaction [Ethanol results in increased expression of HSPA5 mRNA]	29361514
D000431	Ethanol	Ethanol results in increased expression of HSPA5 protein	24224909
D000431	Ethanol	Resveratrol inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]	24224909
D000431	Ethanol	Cimetidine inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]	27983966
D000431	Ethanol	dioscin inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]	24146112
D000431	Ethanol	Drugs, Chinese Herbal inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]	27983966
D000431	Ethanol	Ethanol affects the expression of HSPA5 mRNA	30319688
D000431	Ethanol	Ethanol results in increased expression of HSPA5 mRNA	28119953
D000431	Ethanol	Ethanol results in increased expression of HSPA5 protein	18377926; 24146112; 27983966; 28119953;
D000431	Ethanol	Hydralazine inhibits the reaction [Ethanol results in increased expression of HSPA5 mRNA]	28119953
D000431	Ethanol	Ethanol results in decreased expression of HSPA5 protein	23200777; 24646710;
D000431	Ethanol	Ethanol results in increased expression of HSPA5 protein	24146112
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HSPA5 protein	20227414
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HSPA5 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HSPA5 mRNA	16174780; 17942748; 19400957;
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSPA5 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HSPA5 mRNA	20170705
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HSPA5 mRNA	16174780; 19400957;
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HSPA5 mRNA	23550701
C004912	ethylbenzene	ethylbenzene results in increased expression of HSPA5 protein	12183065
C024565	ethylene dichloride	ethylene dichloride results in increased expression of HSPA5 mRNA	28189721
D005035	Ethylmercury Compounds	Acetylcysteine inhibits the reaction [Ethylmercury Compounds affects the expression of HSPA5 mRNA]	27511942
D005035	Ethylmercury Compounds	Ethylmercury Compounds affects the expression of HSPA5 mRNA	27511942
D005035	Ethylmercury Compounds	Ethylmercury Compounds results in increased expression of HSPA5 mRNA	27511942
D005035	Ethylmercury Compounds	Ethylmercury Compounds results in increased expression of HSPA5 protein	27511942
D000077270	Exenatide	Exenatide inhibits the reaction [Palmitates results in increased expression of HSPA5 protein]	30253173
D000077270	Exenatide	Exenatide inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	30253173
C060802	fangchinoline	Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of HSPA5 protein]	28754437
C060802	fangchinoline	fangchinoline results in increased expression of HSPA5 protein	28754437
D011345	Fenofibrate	Fenofibrate results in decreased expression of HSPA5 mRNA	25596134
D017313	Fenretinide	Ascorbic Acid inhibits the reaction [Fenretinide results in increased expression of HSPA5 protein]	17353921
D017313	Fenretinide	Fenretinide results in increased expression of HSPA5 protein	17353921; 20546536;
D017313	Fenretinide	HSPA5 results in decreased susceptibility to Fenretinide	20546536
D017313	Fenretinide	Fenretinide results in decreased expression of HSPA5 mRNA	28973697
C017875	fisetin	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of HSPA5 protein]	28181380
C017875	fisetin	fisetin results in increased expression of HSPA5 protein	28181380
D005411	Flame Retardants	Flame Retardants results in decreased expression of HSPA5 protein	18550172
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of HSPA5 mRNA	28329830
D016650	Fluorescein-5-isothiocyanate	Fluorescein-5-isothiocyanate binds to HSPA5 protein	27129696
D005459	Fluorides	Fluorides affects the expression of HSPA5 mRNA	20709135
D005472	Fluorouracil	Fluorouracil results in decreased expression of HSPA5 protein	29879413
D005492	Folic Acid	[Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HSPA5 protein	23439872
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HSPA5 gene	20938992
C100163	formetanate	formetanate results in increased expression of HSPA5 protein	16271832
D005632	Fructose	Fructose results in increased expression of HSPA5 mRNA	22698815
D005632	Fructose	Fructose results in increased expression of HSPA5 protein	22698815
D005632	Fructose	Phenylbutyrates inhibits the reaction [Fructose results in increased expression of HSPA5 protein]	22698815
D000077267	Fulvestrant	[Chlordecone co-treated with Fulvestrant] results in increased expression of HSPA5 protein	17640991
C039281	furan	furan binds to HSPA5 protein	22240984
C039281	furan	furan results in decreased expression of HSPA5 mRNA	26194646
C002469	fusarenon-X	fusarenon-X results in decreased expression of HSPA5 mRNA	20682335
D005682	Gadolinium	Gadolinium inhibits the reaction [Glucose results in increased expression of HSPA5 protein]	30076216
C038958	gadolinium chloride	Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of HSPA5 protein]	21198628
C038958	gadolinium chloride	gadolinium chloride affects the expression of HSPA5 mRNA	21198628
C038958	gadolinium chloride	gadolinium chloride results in increased expression of HSPA5 protein	21198628
D005688	Galactosamine	4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 mRNA]	28844859
D005688	Galactosamine	4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 protein]	28844859
D005688	Galactosamine	[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 mRNA	28844859
D005688	Galactosamine	[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 protein	28844859
D005690	Galactose	Galactose results in increased expression of HSPA5 protein	23036742
D005690	Galactose	Phycocyanin inhibits the reaction [Galactose results in increased expression of HSPA5 protein]	23036742
C027235	gallium nitrate	gallium nitrate results in decreased expression of HSPA5 mRNA	18586083
C052659	gambogic acid	Bortezomib promotes the reaction [gambogic acid results in increased expression of HSPA5 protein]	24291039
C052659	gambogic acid	gambogic acid promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]	24291039
C052659	gambogic acid	gambogic acid results in increased expression of HSPA5 protein	24291039
C106014	gedunin	gedunin results in increased expression of HSPA5 mRNA	17010675
C001277	geldanamycin	Bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein]	15141013
C001277	geldanamycin	geldanamycin affects the expression of HSPA5 protein	14576064
C001277	geldanamycin	geldanamycin promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]	15141013
C001277	geldanamycin	geldanamycin results in increased expression of HSPA5 protein	15141013
C056507	gemcitabine	gemcitabine results in increased expression of HSPA5 mRNA	17039268
D005839	Gentamicins	Gentamicins results in increased expression of HSPA5 mRNA	29751043
D005839	Gentamicins	Gentamicins results in increased expression of HSPA5 protein	29751043
D005839	Gentamicins	tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of HSPA5 mRNA]	29751043
D005839	Gentamicins	tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of HSPA5 protein]	29751043
D005839	Gentamicins	Gentamicins results in increased expression of HSPA5 mRNA	17567590; 18172885; 22061828;
D005839	Gentamicins	Gentamicins results in increased expression of HSPA5 protein	17567590
C115325	GIF 0010	Cycloheximide inhibits the reaction [GIF 0010 results in increased expression of HSPA5 mRNA]	9742210
C115325	GIF 0010	GIF 0010 results in increased expression of HSPA5 mRNA	9742210
D005897	Glafenine	Glafenine results in increased expression of HSPA5 mRNA	24136188
C060474	glucogallin	glucogallin inhibits the reaction [Glucose results in increased expression of HSPA5 protein]	25451566
D005944	Glucosamine	4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]	20165829
D005944	Glucosamine	Glucosamine results in increased expression of HSPA5 mRNA	16380481; 19383982; 20165829; 22020377;
D005944	Glucosamine	Glucosamine results in increased expression of HSPA5 protein	15618547; 16380481; 19383982; 22020377;
D005944	Glucosamine	tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]	20165829
D005944	Glucosamine	4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]	30602124
D005944	Glucosamine	4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 protein]	30602124
D005944	Glucosamine	Glucosamine results in decreased expression of HSPA5 mRNA	17178593
D005944	Glucosamine	Glucosamine results in increased expression of HSPA5 mRNA	30602124
D005944	Glucosamine	Glucosamine results in increased expression of HSPA5 protein	30602124
D005944	Glucosamine	Glucosamine results in increased expression of HSPA5 mRNA	20165829
D005947	Glucose	4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 mRNA]	31022492
D005947	Glucose	4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]	31022492
D005947	Glucose	ATF6 protein modified form promotes the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]	31022492
D005947	Glucose	glucogallin inhibits the reaction [Glucose results in increased expression of HSPA5 protein]	25451566
D005947	Glucose	Glucose deficiency results in increased expression of HSPA5 mRNA	12147617; 31022492;
D005947	Glucose	Glucose deficiency results in increased expression of HSPA5 protein	31022492
D005947	Glucose	Glucose results in increased expression of HSPA5 mRNA	16380481
D005947	Glucose	Glucose results in increased expression of HSPA5 protein	25451566
D005947	Glucose	salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]	31022492
D005947	Glucose	XBP1 mRNA alternative form promotes the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]	31022492
D005947	Glucose	2-aminoethoxydiphenyl borate inhibits the reaction [Glucose results in increased expression of HSPA5 protein]	30076216
D005947	Glucose	Gadolinium inhibits the reaction [Glucose results in increased expression of HSPA5 protein]	30076216
D005947	Glucose	Glucose affects the reaction [bisphenol A results in decreased expression of HSPA5 protein]	21705745
D005947	Glucose	Glucose results in decreased expression of HSPA5 mRNA	17178593
D005947	Glucose	Glucose results in increased expression of HSPA5 mRNA	30076216
D005947	Glucose	Glucose results in increased expression of HSPA5 protein	30076216
D005947	Glucose	waixenicin A inhibits the reaction [Glucose results in increased expression of HSPA5 protein]	30076216
D005947	Glucose	Glucose deficiency results in increased expression of HSPA5 protein	21337367
D005947	Glucose	Glucose results in decreased expression of HSPA5 mRNA	24349266
D005947	Glucose	Glucose deficiency results in increased expression of HSPA5 protein	8818631
D005978	Glutathione	Glutathione inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]	20493918
D005978	Glutathione	Glutathione inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	20493918
D005998	Glycine	Glycine inhibits the reaction [Homocysteine results in increased expression of HSPA5 mRNA]	27064126
C010974	glyphosate	glyphosate results in increased methylation of HSPA5 gene	31011160
C010974	glyphosate	glyphosate results in increased expression of HSPA5 mRNA	25636363
D006108	Graphite	Graphite results in increased expression of HSPA5 protein	22157353
D006143	Guanabenz	Guanabenz inhibits the reaction [Acetaminophen results in increased expression of HSPA5 protein]	31524377
D006143	Guanabenz	Guanabenz inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	24892553
C412815	GW 4064	GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA]	28223344
D001556	Hexachlorocyclohexane	Hexachlorocyclohexane results in increased expression of HSPA5 mRNA	24349563
D006710	Homocysteine	Glycine inhibits the reaction [Homocysteine results in increased expression of HSPA5 mRNA]	27064126
D006710	Homocysteine	Homocysteine results in increased expression of HSPA5 mRNA	27064126
D006710	Homocysteine	Homocysteine results in increased expression of HSPA5 protein	19960509; 27064126;
D006820	Hyaluronic Acid	Hyaluronic Acid analog affects the expression of HSPA5 protein	23178681
D006820	Hyaluronic Acid	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HSPA5 protein]	23178681
D006830	Hydralazine	Hydralazine inhibits the reaction [Ethanol results in increased expression of HSPA5 mRNA]	28119953
C029424	hydrazine	hydrazine results in increased expression of HSPA5 mRNA	15370871
C029424	hydrazine	hydrazine results in increased expression of HSPA5 protein	15370871
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of HSPA5 protein	22269385; 23885834;
D006861	Hydrogen Peroxide	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HSPA5 protein]	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of HSPA5 protein	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of HSPA5 protein	22934841
D006861	Hydrogen Peroxide	Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein]	20665602
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of HSPA5 protein	20665602
D006861	Hydrogen Peroxide	nimesulide inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein]	20665602
D006861	Hydrogen Peroxide	KRAS protein mutant form inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein]	22269385
D007052	Ibuprofen	Ibuprofen results in decreased expression of HSPA5 mRNA	25596134
C056599	icariin	icariin results in increased expression of HSPA5 mRNA	19894545
C492448	ICG 001	ICG 001 results in increased expression of HSPA5 mRNA	26191083
D000068877	Imatinib Mesylate	Imatinib Mesylate results in increased expression of HSPA5 protein	28315715
C082359	imidacloprid	imidacloprid results in decreased expression of HSPA5 protein	16884889
C568452	importazole	importazole results in increased expression of HSPA5 mRNA	28942281
D007200	Indican	Indican results in increased expression of HSPA5 mRNA	29380555
D007213	Indomethacin	Indomethacin results in increased expression of HSPA5 mRNA	15131590
D007213	Indomethacin	Indomethacin results in increased expression of HSPA5 protein	15131590
D007213	Indomethacin	Indomethacin results in increased expression of HSPA5 protein	17341418
D007213	Indomethacin	pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein]	17341418
D007213	Indomethacin	SB 203580 inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein]	17341418
D007213	Indomethacin	U 0126 inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein]	17341418
D007213	Indomethacin	Indomethacin results in increased expression of HSPA5 mRNA	18799549
D007460	Iodoacetamide	Iodoacetamide results in increased expression of HSPA5 protein	16005169; 16920763;
D007460	Iodoacetamide	PD 150606 inhibits the reaction [Iodoacetamide results in increased expression of HSPA5 protein]	16920763
D015759	Ionomycin	deoxynivalenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 mRNA]	10652249
D015759	Ionomycin	deoxynivalenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 protein]	10652249
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 mRNA	10652249
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 mRNA	25613284
C033148	iprodione	iprodione results in increased expression of HSPA5 mRNA	16696176
D007529	Isoflavones	[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of HSPA5 protein	22248470
D007529	Isoflavones	[ENNG co-treated with Isoflavones] results in increased expression of HSPA5 protein	22248470
D007531	Isoflurophate	Isoflurophate results in decreased expression of HSPA5 protein	17223147
D007545	Isoproterenol	Isoproterenol results in decreased expression of HSPA5 mRNA	24286936
D007545	Isoproterenol	Isoproterenol results in increased expression of HSPA5 mRNA	21335049
D007559	Ivermectin	Ivermectin results in increased expression of HSPA5 protein	30738135
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of HSPA5 protein	25762632
D007649	Ketamine	Ketamine results in decreased expression of HSPA5 mRNA	20080153
C072105	KN 93	KN 93 inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]	29883672
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPA5 mRNA	18544905
C067713	lactacystin	HSPA5 promotes the reaction [lactacystin results in increased expression of APOB protein]	15618547
C067713	lactacystin	HSPA5 promotes the reaction [lactacystin results in increased secretion of APOB protein]	15618547
C067713	lactacystin	lactacystin inhibits the reaction [HSPA5 results in increased degradation of APOB protein]	15618547
D019344	Lactic Acid	HSPA5 protein affects the reaction [A2M protein modified form results in increased secretion of Lactic Acid]	25720493
D007811	Lanthanum	Lanthanum binds to and results in increased expression of HSPA5 protein	18773883
D007854	Lead	Lead results in increased expression of HSPA5 mRNA	11032763
D007854	Lead	HSPA5 protein affects the reaction [Lead results in decreased expression of OCLN protein]	24431214
D007854	Lead	HSPA5 protein affects the reaction [Lead results in increased phosphorylation of SRC protein]	24431214
D007854	Lead	Lead affects the expression of HSPA5 mRNA	15111246
D007854	Lead	Lead affects the localization of HSPA5 protein	24431214
D007854	Lead	Lead inhibits the reaction [HSPA5 protein binds to FOS enhancer]	15111246
D007854	Lead	Lead inhibits the reaction [HSPA5 protein binds to HRAS enhancer]	15111246
D007854	Lead	Lead results in increased expression of and results in increased activity of HSPA5 protein	15111246
D007854	Lead	Lead results in increased expression of HSPA5 protein	19161237; 24431214;
D007854	Lead	Lead binds to HSPA5 protein	21815057
C008261	lead acetate	ATP7A protein modified form inhibits the reaction [lead acetate binds to HSPA5 protein]	10702365
C008261	lead acetate	Cycloheximide inhibits the reaction [lead acetate results in increased expression of HSPA5 protein]	17915553
C008261	lead acetate	Dactinomycin inhibits the reaction [lead acetate results in increased expression of HSPA5 mRNA]	17915553
C008261	lead acetate	lead acetate affects the expression of HSPA5 mRNA	15111246
C008261	lead acetate	lead acetate affects the localization of HSPA5 protein	21815057
C008261	lead acetate	lead acetate binds to HSPA5 protein	10702365
C008261	lead acetate	lead acetate inhibits the reaction [HSPA5 protein binds to FOS enhancer]	15111246
C008261	lead acetate	lead acetate inhibits the reaction [HSPA5 protein binds to HRAS enhancer]	15111246
C008261	lead acetate	lead acetate results in increased expression of and results in increased activity of HSPA5 protein	15111246
C008261	lead acetate	lead acetate results in increased expression of HSPA5 mRNA	17915553
C008261	lead acetate	lead acetate results in increased expression of HSPA5 protein	10702365; 17915553; 22811615; 25088297; 30445054;
C008261	lead acetate	Nickel inhibits the reaction [lead acetate binds to HSPA5 protein]	10702365
C008261	lead acetate	Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of HSPA5 protein]	25088297
C008261	lead acetate	Zinc inhibits the reaction [lead acetate binds to HSPA5 protein]	10702365
C008261	lead acetate	lead acetate results in increased expression of HSPA5 mRNA	17464326
C029891	lead chloride	lead chloride results in decreased expression of HSPA5 protein	24419708
C029891	lead chloride	lead chloride affects the localization of HSPA5 protein	19720107
C029891	lead chloride	lead chloride results in increased expression of HSPA5 protein	19720107; 21073006;
C017461	lead nitrate	Curcumin inhibits the reaction [lead nitrate results in increased expression of HSPA5 protein]	20071421
C017461	lead nitrate	HSPA5 protein results in decreased susceptibility to lead nitrate	20071421
C017461	lead nitrate	lead nitrate results in increased expression of HSPA5 mRNA	20071421
C017461	lead nitrate	lead nitrate results in increased expression of HSPA5 protein	20071421
C017461	lead nitrate	pyrazolanthrone inhibits the reaction [lead nitrate results in increased expression of HSPA5 protein]	20071421
C017461	lead nitrate	lead nitrate results in increased expression of HSPA5 mRNA	14971657
C017461	lead nitrate	lead nitrate results in increased expression of HSPA5 protein	20435106
C052901	lemongrass oil	lemongrass oil affects the expression of HSPA5 mRNA	25976427
D019787	Linoleic Acid	Linoleic Acid analog results in increased expression of HSPA5 protein	27939595
C002385	linsidomine	linsidomine results in increased expression of HSPA5 mRNA	18086661
C482199	lipopolysaccharide, E coli O55-B5	[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HSPA5 protein	25772430
C482199	lipopolysaccharide, E coli O55-B5	lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA5 protein	25772430
D008070	Lipopolysaccharides	3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]	28245985
D008070	Lipopolysaccharides	4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]	28245985
D008070	Lipopolysaccharides	[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA	24149798
D008070	Lipopolysaccharides	[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein	24149798
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of HSPA5 protein	19675143; 28245985;
D008070	Lipopolysaccharides	Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA]	24149798
D008070	Lipopolysaccharides	Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein]	24149798
D008070	Lipopolysaccharides	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA5 mRNA	22777745
D008070	Lipopolysaccharides	Lipopolysaccharides affects the localization of HSPA5 protein	17475668
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of HSPA5 protein	21355878
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of HSPA5 protein	28245985
D008070	Lipopolysaccharides	Vaticanol B inhibits the reaction [Lipopolysaccharides affects the localization of HSPA5 protein]	17475668
D008070	Lipopolysaccharides	4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 mRNA]	28844859
D008070	Lipopolysaccharides	4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 protein]	28844859
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 mRNA	28844859
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HSPA5 protein	28844859
D008094	Lithium	Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein]	21429313
D008094	Lithium	Lithium results in increased expression of HSPA5 mRNA	16236328
D008094	Lithium	Lithium results in increased expression of HSPA5 protein	16236328; 18296634;
D008094	Lithium	[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 mRNA	21429313
D008094	Lithium	[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein	21429313
C118715	LL Z1640-2	LL Z1640-2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]	15081267
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein]	25398788
D008344	Maneb	[Paraquat co-treated with Maneb] results in increased expression of HSPA5 mRNA	18386188
D008345	Manganese	Manganese results in increased expression of HSPA5 protein	21477646
C025340	manganese chloride	manganese chloride results in increased expression of HSPA5 mRNA	23934647; 23948121;
C025340	manganese chloride	manganese chloride results in increased expression of HSPA5 protein	23934647; 23948121; 25732873;
C025340	manganese chloride	SNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 mRNA]	23934647
C025340	manganese chloride	SNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 protein]	23934647
D008358	Mannose	Mannose inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]	20593179
D008550	Melatonin	Melatonin promotes the reaction [Cyclosporine results in increased expression of HSPA5 protein]	20136702
D008550	Melatonin	Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]	28070110
D008550	Melatonin	Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 protein]	28070110
D008610	Menthol	Menthol results in increased expression of HSPA5 mRNA	26760959
D008610	Menthol	Menthol results in increased expression of HSPA5 protein	26760959
C009760	mequinol	[mequinol co-treated with ESR1 protein] results in increased expression of HSPA5 protein	19269315
D008627	Mercuric Chloride	Cycloheximide inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 protein]	17915553
D008627	Mercuric Chloride	Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 mRNA]	17915553
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of HSPA5 mRNA	15111246
D008627	Mercuric Chloride	Mercuric Chloride promotes the reaction [HSPA5 protein binds to FOS enhancer]	15111246
D008627	Mercuric Chloride	Mercuric Chloride promotes the reaction [HSPA5 protein binds to HRAS enhancer]	15111246
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of and results in increased activity of HSPA5 protein	15111246
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of HSPA5 mRNA	17915553; 30807803;
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of HSPA5 protein	17915553
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of HSPA5 mRNA	17464326
D008628	Mercury	Mercury affects the expression of HSPA5 mRNA	15111246
D008628	Mercury	Mercury promotes the reaction [HSPA5 protein binds to FOS enhancer]	15111246
D008628	Mercury	Mercury promotes the reaction [HSPA5 protein binds to HRAS enhancer]	15111246
D008628	Mercury	Mercury results in increased expression of and results in increased activity of HSPA5 protein	15111246
D008687	Metformin	Metformin results in increased expression of HSPA5 mRNA	25596134
D008694	Methamphetamine	Methamphetamine results in increased expression of HSPA5 mRNA	27323860
D008694	Methamphetamine	Methamphetamine results in increased expression of HSPA5 protein	27323860
D008694	Methamphetamine	Naltrexone inhibits the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]	27323860
D008694	Methamphetamine	norbinaltorphimine inhibits the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]	27323860
D008694	Methamphetamine	Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]	28070110
D008694	Methamphetamine	Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 protein]	28070110
D008694	Methamphetamine	Methamphetamine affects the expression of HSPA5 protein	19826936
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in increased expression of HSPA5 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of HSPA5 mRNA	19564919; 28070110;
D008694	Methamphetamine	Methamphetamine results in increased expression of HSPA5 protein	28070110
D008694	Methamphetamine	SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]	19564919
D008701	Methapyrilene	Methapyrilene results in increased expression of HSPA5 mRNA	15120968; 17450226;
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HSPA5 gene	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of HSPA5 protein	23038002
D008715	Methionine	Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of HSPA5 protein]	23038002
D008724	Methomyl	Methomyl results in increased expression of HSPA5 protein	16271832
C108732	methyl-beta-cyclodextrin	methyl-beta-cyclodextrin inhibits the reaction [(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone results in increased expression of HSPA5 mRNA]	30502353
C108732	methyl-beta-cyclodextrin	methyl-beta-cyclodextrin inhibits the reaction [(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone results in increased expression of HSPA5 mRNA]	30502353
C004925	methylmercuric chloride	Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of HSPA5 protein]	31330229
C004925	methylmercuric chloride	HSPA5 protein promotes the reaction [methylmercuric chloride results in decreased expression of CASP12 protein]	31330229
C004925	methylmercuric chloride	HSPA5 protein promotes the reaction [methylmercuric chloride results in increased expression of CASP3 protein modified form]	31330229
C004925	methylmercuric chloride	HSPA5 protein promotes the reaction [methylmercuric chloride results in increased expression of CASP7 protein modified form]	31330229
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of HSPA5 mRNA	31330229
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of HSPA5 protein	31330229
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of HSPA5 mRNA	20039754
C008493	methylselenic acid	HSPA5 protein affects the reaction [methylselenic acid results in decreased expression of CDK1 protein]	16205645
C008493	methylselenic acid	HSPA5 protein affects the reaction [methylselenic acid results in decreased expression of CDK2 protein]	16205645
C008493	methylselenic acid	HSPA5 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A protein]	16205645
C008493	methylselenic acid	HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of CASP12 protein]	16204082
C008493	methylselenic acid	HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of CASP7 protein]	16204082
C008493	methylselenic acid	HSPA5 protein inhibits the reaction [methylselenic acid results in increased cleavage of PARP1 protein]	16204082
C008493	methylselenic acid	HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of DDIT3 protein]	16204082
C008493	methylselenic acid	HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of HSP90B1 protein]	16204082
C008493	methylselenic acid	HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of HSPA5 protein]	16204082
C008493	methylselenic acid	HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2AK3 protein]	16204082
C008493	methylselenic acid	HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2A protein]	16204082
C008493	methylselenic acid	methylselenic acid inhibits the reaction [CASP7 protein binds to HSPA5 protein]	16204082
C008493	methylselenic acid	methylselenic acid results in increased expression of HSPA5 mRNA	16205645
C008493	methylselenic acid	methylselenic acid results in increased expression of HSPA5 protein	16204082; 16205645; 28161410;
C008493	methylselenic acid	methylselenic acid results in increased expression of HSPA5 protein	19782697
D015741	Metribolone	Metribolone affects the localization of HSPA5 protein	17440980
D015741	Metribolone	Metribolone promotes the reaction [NDRG1 protein binds to HSPA5 protein]	17220478
D015741	Metribolone	Metribolone results in increased expression of HSPA5 protein	17152098
D008797	Metyrapone	Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of HSPA5 protein]	19819344
C063855	microcystin RR	microcystin RR results in increased expression of HSPA5 protein	20196164
D052998	Microcystins	Microcystins results in increased expression of HSPA5 protein	22430071
D008911	Minocycline	Minocycline inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]	22245251
C555916	MitoTEMPO	MitoTEMPO inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]	27784618
C502230	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]	30185695
C028577	monobutyl phthalate	monobutyl phthalate results in increased expression of HSPA5 protein	20553848
C057451	morusin	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of HSPA5 protein]	29421517
C057451	morusin	morusin results in increased expression of HSPA5 protein	29421517
D009151	Mustard Gas	Mustard Gas results in increased expression of HSPA5 mRNA	15674843
D009173	Mycophenolic Acid	Mycophenolic Acid results in decreased expression of HSPA5 mRNA	24356939
C570530	N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine	N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine results in increased expression of HSPA5 mRNA	30133257
D009270	Naloxone	Naloxone results in increased expression of HSPA5 protein	26377394
D009271	Naltrexone	Naltrexone inhibits the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]	27323860
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of HSPA5 mRNA	30138652
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of HSPA5 mRNA	30802478
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of HSPA5 mRNA	30138652
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of HSPA5 protein	22157353
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of HSPA5 mRNA	25554681; 25620056;
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of HSPA5 mRNA	25554681; 25620056;
C031721	naphthalene	naphthalene metabolite binds to HSPA5 protein	16206326
C031721	naphthalene	naphthalene results in increased reduction of HSPA5 protein	19843705
D019888	Nelfinavir	Nelfinavir results in increased expression of HSPA5	21762082
D019888	Nelfinavir	Nelfinavir results in increased expression of HSPA5 protein	19106637; 20594311; 21355074;
D019888	Nelfinavir	Tamoxifen promotes the reaction [Nelfinavir results in increased expression of HSPA5 protein]	20594311
D009532	Nickel	Nickel inhibits the reaction [lead acetate binds to HSPA5 protein]	10702365
C119536	nickel acetate	nickel acetate affects the expression of HSPA5 mRNA	23828170
C119536	nickel acetate	nickel acetate affects the expression of HSPA5 protein	23828170
C119536	nickel acetate	nickel acetate results in increased expression of HSPA5 mRNA	17464326
C022838	nickel chloride	nickel chloride results in increased expression of HSPA5 mRNA	24612858
C028007	nickel monoxide	nickel monoxide results in increased expression of HSPA5 mRNA	28945320
C028007	nickel monoxide	nickel monoxide results in increased expression of HSPA5 protein	28945320
C029938	nickel sulfate	Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]	28296042
C029938	nickel sulfate	Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]	28296042
C029938	nickel sulfate	nickel sulfate results in increased expression of HSPA5 mRNA	28296042
C029938	nickel sulfate	nickel sulfate results in increased expression of HSPA5 protein	28296042
C029938	nickel sulfate	TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]	28296042
C029938	nickel sulfate	TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]	28296042
D009534	Niclosamide	Niclosamide results in increased expression of HSPA5 mRNA	31398420
D009538	Nicotine	Nicotine results in increased expression of HSPA5	24201001
D009538	Nicotine	Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein]	28082123
D009538	Nicotine	Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]	28082123
D009538	Nicotine	Nicotine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	18477628
D009543	Nifedipine	Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 mRNA]	22226148
D009543	Nifedipine	Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 protein]	22226148
C012655	nimesulide	nimesulide inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein]	20665602
D009569	Nitric Oxide	[NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in decreased expression of HSPA5 mRNA	19320461
D009569	Nitric Oxide	[NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in decreased expression of HSPA5 protein	19320461
D009585	Nitrogen Dioxide	Nitrogen Dioxide results in increased expression of HSPA5 protein	8818631
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of HSPA5 mRNA	17616710
C038405	nivalenol	nivalenol results in decreased expression of HSPA5 mRNA	20682335
C000623013	NMS-873	NMS-873 results in increased expression of HSPA5 protein	23892893; 29693262;
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of HSPA5 protein	19716841
D015739	Nocodazole	Nocodazole results in increased expression of HSPA5 protein	26732598
C063998	nodularin	nodularin results in increased expression of HSPA5 mRNA	27061667
C010615	Nonidet P-40	Nonidet P-40 results in decreased expression of HSPA5 mRNA	26552463
C040937	nonivamide	[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of HSPA5 mRNA	17332266
C040937	nonivamide	nonivamide results in increased expression of HSPA5 mRNA	17332266
C025256	nonylphenol	nonylphenol affects the expression of HSPA5 protein	19429228
C025256	nonylphenol	nonylphenol results in increased expression of HSPA5 mRNA	19429228
C051844	norbinaltorphimine	norbinaltorphimine inhibits the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]	27323860
D009638	Norepinephrine	Norepinephrine results in increased expression of HSPA5 mRNA	16338971
D009638	Norepinephrine	Norepinephrine results in increased expression of HSPA5 protein	16338971
D009638	Norepinephrine	CAT protein inhibits the reaction [Norepinephrine results in increased expression of HSPA5 protein]	16338971
D009638	Norepinephrine	NGF protein inhibits the reaction [Norepinephrine results in increased expression of HSPA5 protein]	16338971
C097760	N-palmitoylsphingosine	[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA	28223344
C097760	N-palmitoylsphingosine	N-palmitoylsphingosine results in increased expression of HSPA5 mRNA	28223344
C097760	N-palmitoylsphingosine	tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]	28223344
C097760	N-palmitoylsphingosine	tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA]	28223344
C442478	N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide	N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]	17303341
C570897	NSC668394	NSC668394 results in increased expression of HSPA5 mRNA	27137931
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of HSPA5 mRNA	20971185
C464660	obeticholic acid	obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]	26655953
C464660	obeticholic acid	obeticholic acid inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 protein]	26655953
C025589	ochratoxin A	ochratoxin A metabolite results in increased expression of HSPA5 mRNA	24356939
C025589	ochratoxin A	ochratoxin A results in decreased expression of HSPA5 mRNA	19051279
C025589	ochratoxin A	ochratoxin A results in decreased methylation of HSPA5 promoter	30559759
C025589	ochratoxin A	ochratoxin A results in increased expression of HSPA5 mRNA	24356939; 30559759;
C025589	ochratoxin A	ochratoxin A results in decreased expression of HSPA5 protein	19445961
C025589	ochratoxin A	ochratoxin A results in increased expression of HSPA5 mRNA	28699257
C025589	ochratoxin A	ochratoxin A results in increased expression of HSPA5 protein	28699257
D015242	Ofloxacin	Ofloxacin results in increased expression of HSPA5 mRNA	24582689
D019319	Okadaic Acid	Okadaic Acid results in increased expression of HSPA5 protein	26732598
D019301	Oleic Acid	[Palmitic Acid co-treated with Oleic Acid] affects the expression of HSPA5 mRNA	30547786
D019301	Oleic Acid	Oleic Acid results in increased expression of HSPA5 mRNA	24349266
D000077403	Orlistat	Orlistat results in increased expression of HSPA5 mRNA	17283163
D016627	Oxidopamine	Oxidopamine results in increased expression of HSPA5 mRNA	12486162
D016627	Oxidopamine	Oxidopamine results in increased expression of HSPA5 protein	12486162
D010098	Oxycodone	Oxycodone results in increased expression of HSPA5 protein	26377394
D010100	Oxygen	Oxygen deficiency affects the expression of HSPA5 mRNA	25596134
D010100	Oxygen	Oxygen deficiency inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]	20593179
D010100	Oxygen	Oxygen deficiency results in decreased expression of HSPA5 protein	25937538
D010100	Oxygen	Oxygen deficiency results in increased expression of HSPA5 protein	24680926
D010100	Oxygen	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 mRNA]	22226148
D010100	Oxygen	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 protein]	22226148
D010100	Oxygen	Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 mRNA]	22226148
D010100	Oxygen	Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 protein]	22226148
D010100	Oxygen	Oxygen deficiency results in increased expression of HSPA5 mRNA	22226148
D010100	Oxygen	Oxygen deficiency results in increased expression of HSPA5 protein	21337367; 22226148;
D010126	Ozone	Ozone results in increased expression of HSPA5 mRNA	21543283
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of HSPA5 mRNA	18636392
D017239	Paclitaxel	Paclitaxel results in increased expression of HSPA5 protein	26732598
D010168	Palmitates	Exenatide inhibits the reaction [Palmitates results in increased expression of HSPA5 protein]	30253173
D010168	Palmitates	Palmitates results in increased expression of HSPA5 protein	23576437; 30253173;
D010168	Palmitates	Palmitates results in increased expression of HSPA5 protein	23576437
D019308	Palmitic Acid	[Palmitic Acid co-treated with Oleic Acid] affects the expression of HSPA5 mRNA	30547786
D019308	Palmitic Acid	Palmitic Acid results in increased expression of HSPA5 protein	30738135
D019308	Palmitic Acid	obeticholic acid inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 protein]	26655953
D019308	Palmitic Acid	Palmitic Acid results in increased expression of HSPA5 protein	26655953; 30208301;
D019308	Palmitic Acid	trigonelline inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 protein]	30208301
D019308	Palmitic Acid	Palmitic Acid results in increased expression of HSPA5 mRNA	24349266
D010261	Paraoxon	Paraoxon results in decreased expression of HSPA5 protein	17223147
D010269	Paraquat	EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]	28986289
D010269	Paraquat	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]	30185695
D010269	Paraquat	Paraquat results in increased expression of HSPA5 mRNA	20883675
D010269	Paraquat	Paraquat results in increased expression of HSPA5 protein	19735704; 28986289; 30185695;
D010269	Paraquat	salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]	19735704; 28986289;
D010269	Paraquat	[Paraquat co-treated with Maneb] results in increased expression of HSPA5 mRNA	18386188
D010269	Paraquat	Paraquat results in increased expression of HSPA5 protein	27442881
D010269	Paraquat	Minocycline inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]	22245251
D010269	Paraquat	NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of HSPA5 mRNA]	22678742
D010269	Paraquat	NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]	22678742
D010269	Paraquat	Paraquat results in increased expression of HSPA5 mRNA	17935786; 18198484; 22678742; 24912635;
D010269	Paraquat	Paraquat results in increased expression of HSPA5 protein	22245251; 22678742; 24912635;
D052638	Particulate Matter	Particulate Matter results in increased expression of HSPA5 protein	19675143
D052638	Particulate Matter	Particulate Matter results in increased expression of HSPA5 mRNA	23892126
D010365	Patulin	Patulin results in increased expression of HSPA5 protein	25577197
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of HSPA5 mRNA	18593933
C100442	PD 150606	PD 150606 inhibits the reaction [Iodoacetamide results in increased expression of HSPA5 protein]	16920763
C100442	PD 150606	PD 150606 inhibits the reaction [tert-Butylhydroperoxide results in increased expression of HSPA5 protein]	16920763
C100442	PD 150606	PD 150606 inhibits the reaction [Vitamin K 3 results in increased expression of HSPA5 protein]	16920763
D010396	Penicillamine	Penicillamine results in increased expression of HSPA5 protein	19722195; 22843330;
D010396	Penicillamine	Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of HSPA5 protein]	22945834
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in increased expression of HSPA5 mRNA	19095052
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of HSPA5 protein	25616259
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of HSPA5 mRNA	24642059
C513552	Pep42 peptide	Pep42 peptide binds to HSPA5 protein	21526763
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in increased metabolism of HSPA5 protein	7958552
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in increased phosphorylation of HSPA5 protein	7880882
C522391	perfluorododecanoic acid	perfluorododecanoic acid affects the expression of HSPA5 protein	26168851
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HSPA5 protein	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HSPA5 mRNA	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HSPA5 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HSPA5 mRNA	21318169
C023036	perfluorooctanoic acid	PPARA protein affects the reaction [perfluorooctanoic acid results in decreased expression of HSPA5 mRNA]	21318169
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HSPA5 mRNA	26794494
D010634	Phenobarbital	Phenobarbital results in increased expression of HSPA5 protein	19952500
C412454	phenylalanyl-glycyl-NHO-Bz	phenylalanyl-glycyl-NHO-Bz inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein]	19336499
D010654	Phenylbutyrates	Phenylbutyrates inhibits the reaction [Fructose results in increased expression of HSPA5 protein]	22698815
D010695	Phlorhizin	Phlorhizin results in increased expression of HSPA5 mRNA	22538082
D010798	Phycocyanin	Phycocyanin inhibits the reaction [Galactose results in increased expression of HSPA5 protein]	23036742
D064209	Phytochemicals	Phytochemicals results in decreased expression of HSPA5 protein	22685690
D010862	Pilocarpine	Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein]	21429313
D010862	Pilocarpine	[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 mRNA	21429313
D010862	Pilocarpine	[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein	21429313
C011994	pirimicarb	pirimicarb results in increased expression of HSPA5 protein	16271832
C014153	pirimiphos methyl	pirimiphos methyl results in decreased expression of HSPA5 mRNA	27845199
C006253	pirinixic acid	pirinixic acid results in decreased expression of HSPA5 mRNA	21318169; 23811191;
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in decreased expression of HSPA5 mRNA]	21318169
D010936	Plant Extracts	Plant Extracts results in decreased expression of HSPA5 protein	22685690
D010936	Plant Extracts	Plant Extracts results in increased expression of HSPA5 mRNA	23557933
D010936	Plant Extracts	Plant Extracts results in decreased expression of HSPA5 protein	23994094
C108953	platycodin D	platycodin D results in increased expression of HSPA5 mRNA	22784044
C014758	plumbagin	Acetylcysteine inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]	31276663
C014758	plumbagin	Cycloheximide inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]	31276663
C014758	plumbagin	plumbagin results in increased expression of HSPA5 protein	31276663
D011068	Poly G	Poly G inhibits the reaction [Silicon Dioxide results in increased expression of HSPA5 protein]	31028789
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine affects the expression of HSPA5 mRNA	29337256
D011192	Potassium Dichromate	[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of HSPA5 protein	30974164
D011193	Potassium Iodide	Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 mRNA]	24231001
D011193	Potassium Iodide	Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 protein]	24231001
D044945	Proanthocyanidins	Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of HSPA5 protein]	25088297
C035988	procymidone	procymidone results in decreased expression of HSPA5 mRNA	15686871
D011374	Progesterone	Progesterone affects the expression of HSPA5 mRNA	17251523
C009055	propargylglycine	propargylglycine results in decreased expression of HSPA5 protein	22340159
C045950	propiconazole	propiconazole results in increased expression of HSPA5 mRNA	21278054
C107773	pterostilbene	2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]	25341683
C107773	pterostilbene	Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]	25341683
C107773	pterostilbene	Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of HSPA5 protein]	25341683
C107773	pterostilbene	CAT protein inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]	25341683
C107773	pterostilbene	pterostilbene results in increased expression of HSPA5 mRNA	25341683
C107773	pterostilbene	pterostilbene results in increased expression of HSPA5 protein	25341683
C107773	pterostilbene	Thapsigargin promotes the reaction [pterostilbene results in increased expression of HSPA5 protein]	25341683
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in decreased expression of HSPA5 protein	19264907
D011718	Pyrazinamide	4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]	28063906
D011718	Pyrazinamide	Pyrazinamide results in increased expression of HSPA5 mRNA	28063906
D011718	Pyrazinamide	Pyrazinamide results in increased expression of HSPA5 protein	28063906
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [lead nitrate results in increased expression of HSPA5 protein]	20071421
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein]	17341418
C432165	pyrazolanthrone	pyrazolanthrone results in increased expression of HSPA5 protein	15494209
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 mRNA]	20920558
C031280	pyrazole	G6PDX affects the reaction [pyrazole results in increased expression of HSPA5 protein]	18068688
C031280	pyrazole	pyrazole results in increased expression of HSPA5 mRNA	14610226; 17945193;
C031280	pyrazole	pyrazole results in increased expression of HSPA5 protein	12499123; 14610226; 18068688;
C031280	pyrazole	Vitamin E inhibits the reaction [pyrazole results in increased expression of HSPA5 protein]	18068688
C010423	pyrithione zinc	pyrithione zinc results in increased expression of HSPA5 mRNA	21424779
C020972	pyrrolidine dithiocarbamic acid	[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 mRNA	20920558
C020972	pyrrolidine dithiocarbamic acid	[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 protein	20920558
C020972	pyrrolidine dithiocarbamic acid	pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 mRNA]	20920558
D011794	Quercetin	[Cisplatin co-treated with Quercetin] results in increased expression of HSPA5 mRNA	27514524
D011794	Quercetin	HSPA5 protein inhibits the reaction [Quercetin results in increased expression of CASP3 protein modified form]	19017364
D011794	Quercetin	HSPA5 protein inhibits the reaction [Quercetin results in increased expression of CASP7 protein modified form]	19017364
D011794	Quercetin	HSPA5 protein inhibits the reaction [Quercetin results in increased expression of MAPK8 protein modified form]	19017364
D011794	Quercetin	HSPA5 protein inhibits the reaction [Quercetin results in increased expression of MAPK9 protein modified form]	19017364
D011794	Quercetin	HSPA5 protein results in decreased susceptibility to Quercetin	19017364
D011794	Quercetin	Quercetin inhibits the reaction [Calcimycin results in increased expression of HSPA5 mRNA]	19428936
D011794	Quercetin	Quercetin inhibits the reaction [Calcimycin results in increased expression of HSPA5 protein]	19428936
D011794	Quercetin	Quercetin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	19428936
D011794	Quercetin	Quercetin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	19428936
D011794	Quercetin	Quercetin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]	19428936
D011794	Quercetin	Quercetin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	19428936
D011794	Quercetin	Quercetin inhibits the reaction [zearalenol results in increased expression of HSPA5 protein]	26584763
D011794	Quercetin	Quercetin results in decreased expression of HSPA5 mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of HSPA5 mRNA	19017364
D011794	Quercetin	Quercetin results in increased expression of HSPA5 protein	14750173; 15221776; 19017364; 22431435; 24368982; 25611565; 30152185;
D011794	Quercetin	[Quercetin results in increased susceptibility to Cisplatin] which results in increased expression of HSPA5 protein	25611565
D011794	Quercetin	tauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased expression of HSPA5 protein]	25611565
D011794	Quercetin	Quercetin affects the expression of HSPA5 mRNA	18178720
D000077185	Resveratrol	Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of HSPA5 protein]]	26772155
D000077185	Resveratrol	Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]]	26772155
D000077185	Resveratrol	Acetylcysteine inhibits the reaction [Resveratrol results in increased expression of HSPA5 protein]	26772155
D000077185	Resveratrol	Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of HSPA5 protein]	26772155
D000077185	Resveratrol	Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 mRNA]	24149798
D000077185	Resveratrol	Resveratrol inhibits the reaction [[Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of HSPA5 protein]	24149798
D000077185	Resveratrol	Resveratrol inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]	24224909
D000077185	Resveratrol	Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	26772155
D000077185	Resveratrol	Resveratrol results in decreased expression of HSPA5 mRNA	20717957
D000077185	Resveratrol	Resveratrol results in decreased expression of HSPA5 protein	20717957
D000077185	Resveratrol	Resveratrol results in increased expression of HSPA5 protein	17914584; 18089832; 20198347; 26772155;
D000077185	Resveratrol	[Resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]	21321189
D000077185	Resveratrol	Resveratrol results in increased expression of HSPA5 protein	25505154
D000077185	Resveratrol	Resveratrol inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]	26055348
D000077185	Resveratrol	Resveratrol inhibits the reaction [Rotenone results in increased expression of HSPA5 mRNA]	27016191
D000077185	Resveratrol	Resveratrol results in decreased expression of HSPA5 protein	24395567
D012172	Retinaldehyde	Retinaldehyde results in increased expression of HSPA5 protein	25331497
D012176	Retinoids	Retinoids results in increased expression of HSPA5 protein	28886987
D012293	Rifampin	4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 mRNA]	27470132
D012293	Rifampin	4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]	27470132
D012293	Rifampin	Rifampin results in increased expression of HSPA5 mRNA	27470132
D012293	Rifampin	Rifampin results in increased expression of HSPA5 protein	27470132
D012293	Rifampin	ATF4 mutant form inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]	24638036
D012293	Rifampin	Rifampin results in increased expression of HSPA5 protein	24638036
D000077285	Rimonabant	[Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of HSPA5 mRNA]	31054322
C038849	roridin A	roridin A results in increased degradation of and results in decreased expression of HSPA5 protein	19336499
D000077154	Rosiglitazone	Rosiglitazone results in increased expression of HSPA5 mRNA	15525695
D000077154	Rosiglitazone	Rosiglitazone results in increased expression of HSPA5 protein	15525695; 20816668;
D000077154	Rosiglitazone	Rosiglitazone results in decreased expression of HSPA5 mRNA	25596134
D000077154	Rosiglitazone	Rosiglitazone results in increased expression of HSPA5 mRNA	20816668
D012402	Rotenone	MIR384 mRNA promotes the reaction [Rotenone results in decreased expression of HSPA5 mRNA]	26864693
D012402	Rotenone	Rotenone results in decreased expression of HSPA5 mRNA	26864693
D012402	Rotenone	4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]	17459145
D012402	Rotenone	Rotenone results in increased expression of HSPA5 protein	17459145; 25428620;
D012402	Rotenone	salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]	25428620
D012402	Rotenone	Resveratrol inhibits the reaction [Rotenone results in increased expression of HSPA5 mRNA]	27016191
D012402	Rotenone	Rotenone results in increased expression of HSPA5 mRNA	27016191
D012402	Rotenone	Rotenone results in increased expression of HSPA5 protein	26446018
D012402	Rotenone	Rotenone results in increased oxidation of HSPA5 protein	30951809
D012402	Rotenone	salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]	26446018
C085746	rottlerin	rottlerin results in increased expression of HSPA5 protein	22410117
C113180	S 3483	S 3483 promotes the reaction [Vitamin K 3 results in increased expression of HSPA5 protein]	19819344
C496827	salubrinal	EIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]	28986289
C496827	salubrinal	salubrinal inhibits the reaction [4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased expression of HSPA5 protein]]	31022492
C496827	salubrinal	salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]	19735704; 28986289;
C496827	salubrinal	salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]	25428620
C496827	salubrinal	salubrinal inhibits the reaction [Rotenone results in increased expression of HSPA5 protein]	26446018
C496827	salubrinal	salubrinal inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]	28844859
C496827	salubrinal	salubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HSPA5 protein]	24932542
C496827	salubrinal	salubrinal results in increased expression of HSPA5 protein	24932542
C076944	salvianolic acid B	salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]	28495616
D012503	Saponins	Saponins results in decreased expression of HSPA5 protein	23994094
D019258	Saquinavir	Saquinavir results in increased expression of HSPA5 protein	19147209
C028268	satratoxin G	satratoxin G results in increased degradation of and results in decreased expression of HSPA5 protein	19336499
C093642	SB 203580	SB 203580 inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein]	17341418
C093642	SB 203580	SB 203580 results in increased expression of HSPA5 protein	15494209
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in increased expression of HSPA5 mRNA	19564919
C534628	SCH 23390	SCH 23390 inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]	17303341
C534628	SCH 23390	SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]	19564919
C015499	schizandrin B	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HSPA5 mRNA]	31150632
D012643	Selenium	Selenium inhibits the reaction [Cadmium results in increased expression of HSPA5]	25805271
D012645	Selenomethionine	Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]	29454614
D012645	Selenomethionine	Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein]	29454614
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of HSPA5 protein	25895662
D012822	Silicon Dioxide	[Silicon Dioxide analog co-treated with Silver] results in increased expression of HSPA5 mRNA	22245057
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of HSPA5 mRNA	22245057
D012822	Silicon Dioxide	Poly G inhibits the reaction [Silicon Dioxide results in increased expression of HSPA5 protein]	31028789
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of HSPA5 protein	31028789
D012834	Silver	Silver analog results in increased expression of HSPA5 mRNA	23800688
D012834	Silver	Silver analog results in increased expression of HSPA5 protein	23800688
D012834	Silver	[Silicon Dioxide analog co-treated with Silver] results in increased expression of HSPA5 mRNA	22245057
D018030	Silver Compounds	Silver Compounds results in increased expression of HSPA5 mRNA	29306025
D018030	Silver Compounds	Silver Compounds results in increased expression of HSPA5 protein	29306025
D019821	Simvastatin	Simvastatin results in increased expression of HSPA5 mRNA	18664198; 19253821;
D019821	Simvastatin	Simvastatin results in increased expression of HSPA5 protein	19253821
D020123	Sirolimus	Sirolimus results in decreased expression of HSPA5 mRNA	24356939
D020123	Sirolimus	PPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein]	24898257
D020123	Sirolimus	[Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein	24898257
D020123	Sirolimus	Sirolimus inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]	29870746
D012906	Smoke	Smoke results in increased expression of HSPA5 mRNA	18206657
C534922	SNX 2112	SNX 2112 results in decreased expression of HSPA5 protein	23777986
C009277	sodium arsenate	sodium arsenate results in decreased expression of HSPA5 mRNA	24349563
C009277	sodium arsenate	sodium arsenate results in increased expression of HSPA5 mRNA	30953684
C017947	sodium arsenite	sodium arsenite promotes the reaction [Ethanol results in increased expression of HSPA5 mRNA]	29361514
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPA5 mRNA	29361514
C017947	sodium arsenite	sodium arsenite results in decreased expression of HSPA5 protein	15899475
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPA5 protein	21925251
C017947	sodium arsenite	Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HSPA5 protein]	21911445
C017947	sodium arsenite	sodium arsenite affects the localization of HSPA5 protein	21911445
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPA5 mRNA	17451858; 21911445;
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPA5 protein	21911445
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPA5 protein	29459688
C016104	sodium bichromate	sodium bichromate results in increased expression of HSPA5 mRNA	24612858
C025451	sodium bisulfide	sodium bisulfide results in increased expression of HSPA5 protein	22340159
D012969	Sodium Fluoride	Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 mRNA]	24231001
D012969	Sodium Fluoride	Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 protein]	24231001
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of HSPA5 mRNA	24231001
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of HSPA5 protein	24231001
D012969	Sodium Fluoride	Sodium Fluoride affects the expression of HSPA5 protein	25132241
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of HSPA5 protein	27548804
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of HSPA5 mRNA	21626649
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of HSPA5 protein	21626649
D012969	Sodium Fluoride	Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 protein]	30633982
D012969	Sodium Fluoride	Sodium Fluoride affects the expression of HSPA5 mRNA	25132241
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of HSPA5 mRNA	23707774
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of HSPA5 protein	23707774; 30633982;
D018038	Sodium Selenite	Sodium Selenite results in increased expression of HSPA5 protein	28161410
D000077157	Sorafenib	EIF2AK3 protein promotes the reaction [[Sorafenib co-treated with Vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]	18787411
D000077157	Sorafenib	FADD protein promotes the reaction [[Sorafenib co-treated with Vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]	18787411
D000077157	Sorafenib	[Sorafenib co-treated with Vorinostat] promotes the reaction [FAS protein binds to CASP8 protein binds to ATG5 protein binds to HSPA5 protein]	18787411
C558809	SR1001	SR1001 results in decreased expression of HSPA5 protein	28698385
C559087	SR 1078	SR 1078 results in increased expression of HSPA5 protein	28698385
C110630	SR 144528	[Rimonabant co-treated with SR 144528] inhibits the reaction [Dronabinol results in increased expression of HSPA5 mRNA]	31054322
C556690	STF 083010	STF 083010 inhibits the reaction [Carbon Tetrachloride results in increased expression of HSPA5 protein]	30538632
D013311	Streptozocin	[Streptozocin co-treated with Dietary Fats] results in increased expression of HSPA5 protein	26522834
D013311	Streptozocin	Streptozocin results in increased expression of HSPA5 protein	24967692
D013311	Streptozocin	sulforafan inhibits the reaction [Streptozocin results in increased expression of HSPA5 protein]	24967692
D013311	Streptozocin	4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of HSPA5 protein]	30980806
D013311	Streptozocin	Streptozocin results in decreased expression of HSPA5 protein	19634143
D013311	Streptozocin	Streptozocin results in increased expression of HSPA5 protein	30980806
D013311	Streptozocin	Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPA5 protein]	19634143
C059873	sulfamethoxazole hydroxylamine	sulfamethoxazole hydroxylamine results in increased expression of HSPA5 protein	16005169
C016766	sulforafan	sulforafan inhibits the reaction [Streptozocin results in increased expression of HSPA5 protein]	24967692
D013458	Sulfur Dioxide	Sulfur Dioxide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HSPA5 protein]	30503585
D000077210	Sunitinib	Sunitinib results in increased expression of HSPA5 mRNA	31533062
C446685	systhane	systhane results in decreased expression of HSPA5 mRNA	16643972
D013605	T-2 Toxin	T-2 Toxin results in increased expression of HSPA5 protein	31170431
D013605	T-2 Toxin	T-2 Toxin results in increased degradation of and results in decreased expression of HSPA5 protein	19336499
D013605	T-2 Toxin	Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 mRNA]	29454614
D013605	T-2 Toxin	Selenomethionine inhibits the reaction [T-2 Toxin results in increased expression of HSPA5 protein]	29454614
D013605	T-2 Toxin	T-2 Toxin affects the expression of HSPA5 protein	26141394
D013605	T-2 Toxin	T-2 Toxin results in increased expression of HSPA5 mRNA	29454614
D013605	T-2 Toxin	T-2 Toxin results in increased expression of HSPA5 protein	29454614
D016559	Tacrolimus	Tacrolimus results in increased expression of HSPA5 mRNA	25270620
C557331	TAK-875	TAK-875 results in increased expression of HSPA5 mRNA	30243991
D013629	Tamoxifen	Tamoxifen promotes the reaction [Nelfinavir results in increased expression of HSPA5 protein]	20594311
D013629	Tamoxifen	Tamoxifen results in increased expression of HSPA5 protein	19812351
D013629	Tamoxifen	Tamoxifen affects the expression of HSPA5 mRNA	17555576
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]	23038002
D013629	Tamoxifen	Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of HSPA5 protein]	23038002
D013629	Tamoxifen	Tamoxifen results in increased expression of HSPA5 mRNA	19400957
C112765	tanespimycin	tanespimycin results in increased expression of HSPA5 protein	16357177
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]	20165829
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased expression of HSPA5 protein]	25611565
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	12198651
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]	24802810
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 mRNA]	27853103
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 protein]	25160872
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of HSPA5 mRNA]	29751043
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of HSPA5 protein]	29751043
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]	28223344
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA]	28223344
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in increased expression of HSPA5 protein	25160872
D000077333	Telmisartan	Telmisartan results in decreased expression of HSPA5 protein	19102871
C003959	TEMPO	TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]	28296042
C003959	TEMPO	TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]	28296042
C001803	tempol	tempol inhibits the reaction [PRKAA2 protein affects the expression of HSPA5 protein]	21145922
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of HSPA5 mRNA	12766906
D020122	tert-Butylhydroperoxide	PD 150606 inhibits the reaction [tert-Butylhydroperoxide results in increased expression of HSPA5 protein]	16920763
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of HSPA5 protein	16005169; 16920763;
D013739	Testosterone	Testosterone affects the expression of HSPA5 mRNA	17003280
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of HSPA5 protein	27484784
C000591600	tetrachlorobenzoquinone	4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HSPA5 protein]	27484784
C000591600	tetrachlorobenzoquinone	Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HSPA5 protein]	27484784
D013749	Tetrachlorodibenzodioxin	Cadmium affects the reaction [Tetrachlorodibenzodioxin affects the expression of HSPA5 protein]	29107029
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSPA5 protein	29107029
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSPA5 mRNA	24349563
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSPA5 mRNA	16039398
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSPA5 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSPA5 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSPA5 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	EIF2S1 mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of HSPA5 protein]	24932542
D013749	Tetrachlorodibenzodioxin	salubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HSPA5 protein]	24932542
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HSPA5 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSPA5 protein	16548065
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSPA5 protein	12361703; 24932542;
D013755	Tetradecanoylphorbol Acetate	deoxynivalenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 mRNA]	10652249
D013755	Tetradecanoylphorbol Acetate	deoxynivalenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 protein]	10652249
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 mRNA	10652249
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA5 mRNA	25613284
C009438	tetrandrine	tetrandrine results in increased expression of HSPA5 protein	26822499
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5 protein	20071421
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5 protein	17416481
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5 mRNA	15131590
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5 protein	15131590
D019284	Thapsigargin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	19428936
D019284	Thapsigargin	ATF6 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]	27358234
D019284	Thapsigargin	demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	26264395
D019284	Thapsigargin	Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	16298333
D019284	Thapsigargin	EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]	27358234
D019284	Thapsigargin	[HSPA5 protein results in decreased transport of Calcium] which results in increased susceptibility to Thapsigargin	26085089
D019284	Thapsigargin	Quercetin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	19428936
D019284	Thapsigargin	Quercetin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	19428936
D019284	Thapsigargin	tauroursodeoxycholic acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	12198651
D019284	Thapsigargin	Thapsigargin promotes the reaction [pterostilbene results in increased expression of HSPA5 protein]	25341683
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5 mRNA	12147617; 17283163; 17332266; 19135031; 19428936; 21320468; 21692457; 21694771; 22378314; 22800509; 27578021; 27587023; 29126784; 29453283;
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5 protein	12198651; 16298333; 17353921; 17416481; 17915553; 19139269; 19428936; 20626587; 21320468; 21692457; 23885834; 25324550; 25611565; 26264395; 27358234; 27578021; 27587023; 29126784; 29453283;
D019284	Thapsigargin	Wortmannin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	19428936
D019284	Thapsigargin	Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	20493918
D019284	Thapsigargin	Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	20493918
D019284	Thapsigargin	Glutathione inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	20493918
D019284	Thapsigargin	PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	22509299
D019284	Thapsigargin	PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]	22509299
D019284	Thapsigargin	[Thapsigargin co-treated with HRAS protein] results in increased expression of HSPA5 protein	24898257
D019284	Thapsigargin	Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	27638049
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5 mRNA	14610226; 15019097; 18799549; 20477944; 22509299; 25324550; 28223344;
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5 protein	17475668; 17915553; 18799549; 20493918; 20589738; 22509299; 25324550;
D019284	Thapsigargin	Vaticanol B inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	17475668
D019284	Thapsigargin	4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	28844859
D019284	Thapsigargin	4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	28844859
D019284	Thapsigargin	Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	17915553
D019284	Thapsigargin	Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	17915553
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5	22425709
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5 mRNA	16338971; 17915553; 28844859;
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5 protein	16236328; 16338971; 17416481; 17915553; 18477628; 21198628; 28315715; 28844859;
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPA5 protein	16759985; 16920763; 17416481;
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]	23892647
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]	30605698
D013883	Thiostrepton	Thiostrepton results in increased expression of HSPA5 mRNA	22321511
C003466	thymoquinone	4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased expression of HSPA5 protein]	29981725
C003466	thymoquinone	thymoquinone results in increased expression of HSPA5 mRNA	29981725
C003466	thymoquinone	thymoquinone results in increased expression of HSPA5 protein	29981725
C066185	tingenin B	tingenin B results in increased expression of HSPA5 protein	27720947
C009495	titanium dioxide	titanium dioxide results in increased expression of HSPA5 mRNA	23557971; 27760801;
C423915	TO-901317	TO-901317 results in decreased expression of HSPA5 mRNA	15302862
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of HSPA5 mRNA	27404394
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of HSPA5 protein	30291989
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution analog results in increased expression of HSPA5 protein	25568320
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HSPA5 mRNA	27865774; 28065790;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HSPA5 protein	29505817; 30579903;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased metabolism of HSPA5 protein	23396223
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HSPA5 mRNA	30659203
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HSPA5 protein	24486158
D014050	Toluene	Toluene results in increased expression of HSPA5 protein	12183065
D014050	Toluene	Toluene results in increased expression of HSPA5 mRNA	22967744
D014118	Toxins, Biological	Toxins, Biological affects the expression of HSPA5 mRNA	19682533
C495469	trans-3-(4'-hydroxyphenyl)-2-propenoic acid	trans-3-(4'-hydroxyphenyl)-2-propenoic acid results in decreased expression of HSPA5 protein	29879413
C495469	trans-3-(4'-hydroxyphenyl)-2-propenoic acid	trans-3-(4'-hydroxyphenyl)-2-propenoic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of HSPA5 protein]	29879413
C495469	trans-3-(4'-hydroxyphenyl)-2-propenoic acid	trans-3-(4'-hydroxyphenyl)-2-propenoic acid results in increased expression of HSPA5 protein	29879413
C034697	transplatin	transplatin results in decreased expression of HSPA5 mRNA	11099651
D014212	Tretinoin	MGAT5 protein inhibits the reaction [Tretinoin results in increased expression of HSPA5 protein]	17031849
D014212	Tretinoin	Tretinoin results in decreased expression of HSPA5 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of HSPA5 protein	17031849; 19960509;
D014212	Tretinoin	Tretinoin results in increased expression of HSPA5 mRNA	22498432
D014212	Tretinoin	Tretinoin results in increased expression of HSPA5 protein	22498432
D014212	Tretinoin	Tretinoin results in increased expression of HSPA5 mRNA	20488242
C032910	triadimefon	triadimefon results in decreased expression of HSPA5 mRNA	16643972
C011559	tributyltin	4-phenylbutyric acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]	23743301
C011559	tributyltin	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]	23743301
C011559	tributyltin	Dantrolene inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]	23743301
C011559	tributyltin	tributyltin results in decreased expression of HSPA5 mRNA	27678064
C011559	tributyltin	tributyltin results in increased expression of HSPA5 protein	23743301
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of HSPA5 mRNA	15363585
C012589	trichostatin A	trichostatin A affects the expression of HSPA5 mRNA	28542535
C012589	trichostatin A	trichostatin A results in decreased expression of HSPA5 mRNA	24935251
C009540	triclocarban	triclocarban results in increased expression of HSPA5 mRNA	30592132
C009540	triclocarban	triclocarban results in increased expression of HSPA5 protein	30592132
D014260	Triclosan	Triclosan results in increased expression of HSPA5 protein	30219713
D014266	Trientine	Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPA5 protein]	19634143
C009560	trigonelline	trigonelline inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 protein]	30208301
D014302	Trinitrobenzenesulfonic Acid	Sulfur Dioxide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HSPA5 protein]	30503585
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of HSPA5 protein	30503585
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of HSPA5 mRNA	21346803
C050414	tripterine	tripterine results in increased expression of HSPA5 mRNA	17010675
C001899	triptolide	triptolide results in decreased expression of HSPA5 protein	26990902
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HSPA5 mRNA	26743178
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 mRNA	26743178
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein	26743178
C016805	tris(1,3-dichloro-2-propyl)phosphate	4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]	27816613
C016805	tris(1,3-dichloro-2-propyl)phosphate	4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]	27816613
C016805	tris(1,3-dichloro-2-propyl)phosphate	Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]	27816613
C016805	tris(1,3-dichloro-2-propyl)phosphate	Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]	27816613
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein	27816613
D000077288	Troglitazone	HSPA5 protein affects the susceptibility to Troglitazone	15525695
D000077288	Troglitazone	Troglitazone results in increased expression of HSPA5 mRNA	15525695; 19631733;
D000077288	Troglitazone	Troglitazone results in increased expression of HSPA5 protein	15525695
D000077288	Troglitazone	Troglitazone results in decreased expression of HSPA5 mRNA	25596134
D014415	Tunicamycin	Tunicamycin results in increased expression of HSPA5 protein	20071421
D014415	Tunicamycin	Tunicamycin results in increased expression of HSPA5 protein	17416481
D014415	Tunicamycin	Tunicamycin results in increased expression of HSPA5 mRNA	30592132
D014415	Tunicamycin	Bortezomib inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	16357177
D014415	Tunicamycin	ERGIC3 protein inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	27588471
D014415	Tunicamycin	MT2A protein inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	24680926
D014415	Tunicamycin	Quercetin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]	19428936
D014415	Tunicamycin	Quercetin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	19428936
D014415	Tunicamycin	SIRT7 protein inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]	24210820
D014415	Tunicamycin	Tunicamycin promotes the reaction [HSPA5 protein binds to CDH13 protein]	23544152
D014415	Tunicamycin	Tunicamycin results in increased expression of HSPA5 mRNA	12147617; 15049342; 19383982; 19428936; 20196124; 21320468; 22378314; 23544152; 24210820; 24312631; 28688763; 29453283; 29723631; 30592132;
D014415	Tunicamycin	Tunicamycin results in increased expression of HSPA5 protein	15049342; 16357177; 17416481; 19139269; 19428936; 19735704; 20196124; 20593179; 20626587; 21320468; 22959463; 23544152; 27358234; 27588471; 29453283; 30592132;
D014415	Tunicamycin	Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]	20015086
D014415	Tunicamycin	Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	20015086
D014415	Tunicamycin	[ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of HSPA5 mRNA	29793971
D014415	Tunicamycin	Exenatide inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	30253173
D014415	Tunicamycin	HSPA5 protein affects the reaction [[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein]	24898257
D014415	Tunicamycin	HSPA5 protein affects the reaction [[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of RB1 protein]	24898257
D014415	Tunicamycin	PTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased expression of HSPA5 protein]	22509299
D014415	Tunicamycin	[Resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]	21321189
D014415	Tunicamycin	[Tunicamycin co-treated with HRAS protein] results in increased expression of HSPA5 protein	24898257
D014415	Tunicamycin	Tunicamycin results in increased expression of HSPA5 mRNA	15019097; 20015086; 21321189; 22001960; 22509299; 25160872; 25324550; 28698385; 29380555;
D014415	Tunicamycin	Tunicamycin results in increased expression of HSPA5 protein	18799549; 19336499; 20015086; 20477944; 22509299; 25160872; 25324550; 28698385; 30253173;
D014415	Tunicamycin	4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]	28844859
D014415	Tunicamycin	Guanabenz inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	24892553
D014415	Tunicamycin	Nicotine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	18477628
D014415	Tunicamycin	salubrinal inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]	28844859
D014415	Tunicamycin	Tunicamycin results in increased expression of HSPA5 mRNA	24291486; 24892553; 28844859;
D014415	Tunicamycin	Tunicamycin results in increased expression of HSPA5 protein	15049342; 17416481; 18477628; 20071420; 24680926; 24892553; 28844859;
D014415	Tunicamycin	HSPA5 results in decreased susceptibility to Tunicamycin	17464326; 18086661;
D014415	Tunicamycin	Tunicamycin results in increased expression of HSPA5 protein	15049342; 16920763; 17416481;
D014415	Tunicamycin	Tunicamycin results in increased expression of HSPA5 protein	8818631
C113580	U 0126	U 0126 inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein]	17341418
C113580	U 0126	U 0126 promotes the reaction [cadmium acetate results in increased expression of HSPA5 protein]	29870746
D014501	Uranium	Uranium results in increased expression of HSPA5 mRNA	14971665
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of HSPA5 mRNA	24312631
C005466	ursolic acid	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]	24802810
C005466	ursolic acid	Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]	24802810
C005466	ursolic acid	tauroursodeoxycholic acid inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]	24802810
C005466	ursolic acid	ursolic acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein]	24802810
C005466	ursolic acid	ursolic acid results in increased expression of HSPA5 protein	24802810
C073339	usnic acid	[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA5 mRNA	22777745
D014635	Valproic Acid	Valproic Acid affects the expression of HSPA5 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of HSPA5 mRNA	23179753; 27188386; 29154799;
D014635	Valproic Acid	Valproic Acid affects the expression of HSPA5 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in increased expression of HSPA5 protein	16236328
C522219	Vaticanol B	Vaticanol B inhibits the reaction [Lipopolysaccharides affects the localization of HSPA5 protein]	17475668
C522219	Vaticanol B	Vaticanol B inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]	17475668
D000077484	Vemurafenib	[KRAS protein mutant form affects the susceptibility to Vemurafenib] which results in increased expression of HSPA5 protein	27222248
C490154	versipelostatin	versipelostatin results in decreased expression of HSPA5 mRNA	21526763
C025643	vinclozolin	vinclozolin results in decreased expression of HSPA5 mRNA	15686871; 23034163;
D014752	Vinyl Chloride	Vinyl Chloride results in increased expression of HSPA5 mRNA	31445928
D014810	Vitamin E	Vitamin E inhibits the reaction [pyrazole results in increased expression of HSPA5 protein]	18068688
D024482	Vitamin K 2	Vitamin K 2 results in decreased expression of HSPA5 protein	29432837
D024483	Vitamin K 3	Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of HSPA5 protein]	19819344
D024483	Vitamin K 3	S 3483 promotes the reaction [Vitamin K 3 results in increased expression of HSPA5 protein]	19819344
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of HSPA5 protein	19819344
D024483	Vitamin K 3	PD 150606 inhibits the reaction [Vitamin K 3 results in increased expression of HSPA5 protein]	16920763
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of HSPA5 mRNA	18086661
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of HSPA5 protein	16920763
C032731	vitexin	vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA]	29545167
D000077337	Vorinostat	EIF2AK3 protein promotes the reaction [[Sorafenib co-treated with Vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]	18787411
D000077337	Vorinostat	FADD protein promotes the reaction [[Sorafenib co-treated with Vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]	18787411
D000077337	Vorinostat	[Sorafenib co-treated with Vorinostat] promotes the reaction [FAS protein binds to CASP8 protein binds to ATG5 protein binds to HSPA5 protein]	18787411
C568854	waixenicin A	waixenicin A inhibits the reaction [Glucose results in increased expression of HSPA5 protein]	30076216
D014874	Water Pollutants, Chemical	Water Pollutants, Chemical results in increased expression of HSPA5 mRNA	22899542
C009684	withaferin A	withaferin A results in increased expression of and affects the localization of HSPA5 protein	23226310
C009684	withaferin A	withaferin A results in increased expression of HSPA5 mRNA	23226310
D000077191	Wortmannin	Wortmannin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]	19428936
D019820	Xanthine	[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein	19464573
D014992	Xylenes	Xylenes results in increased expression of HSPA5 protein	12183065
C029659	zearalenol	Quercetin inhibits the reaction [zearalenol results in increased expression of HSPA5 protein]	26584763
C029659	zearalenol	zearalenol results in increased expression of HSPA5 protein	26584763
D015025	Zearalenone	AIFM1 protein promotes the reaction [Zearalenone results in increased expression of HSPA5 protein]	28011299
D015025	Zearalenone	Zearalenone results in increased expression of HSPA5 protein	28011299
D015025	Zearalenone	4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of HSPA5 protein]	30394307
D015025	Zearalenone	Zearalenone results in increased expression of HSPA5 protein	30394307
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of HSPA5 mRNA	18593933
D015032	Zinc	Zinc inhibits the reaction [lead acetate binds to HSPA5 protein]	10702365
D015034	Zinc Oxide	Zinc Oxide analog results in increased expression of HSPA5 mRNA	25680694
D000077211	Zoledronic Acid	Zoledronic Acid results in increased expression of HSPA5 mRNA	25596134

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0007	Acetylation
KW-0067	ATP-binding
KW-0143	Chaperone
KW-0963	Cytoplasm
KW-0903	Direct protein sequencing
KW-0256	Endoplasmic reticulum
KW-0378	Hydrolase
KW-1017	Isopeptide bond
KW-0488	Methylation
KW-0944	Nitration
KW-0547	Nucleotide-binding
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0732	Signal
KW-0832	Ubl conjugation

Interpro

InterPro ID	InterPro Term
IPR043129	ATPase_NBD
IPR042050	BIP_NBD
IPR018181	Heat_shock_70_CS
IPR029048	HSP70_C_sf
IPR029047	HSP70_peptide-bd_sf
IPR013126	Hsp_70_fam

PROSITE

PROSITE ID	PROSITE Term
PS00014	ER_TARGET
PS00297	HSP70_1
PS00329	HSP70_2
PS01036	HSP70_3

Pfam

Pfam ID	Pfam Term
PF00012	HSP70

Gene: HSPA5

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction