| Tag | Content |
|---|---|
| Uniprot ID | P12260; Q1JPK3; |
| Entrez ID | |
| Genbank protein ID | ABF57306.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Coagulation factor XIII A chain |
| Gene symbol | F13A1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. |
| Sequence | MSESSGTAFG GRRAIPPNTS NAAENDPPTV ELQGLVPRGF NPQDYLNVTN VHLFKERWDS 60 NKVDHHTDKY SNDKLIVRRG QSFYIQIDFN RPYDPTRDLF RVEYVIGLYP QENKGTYIPV 120 PLVSELQSGK WGAKVVMRED RSVRLSVQSS ADCIVGKFRM YVAVWTPYGV IRTSRNPETD 180 TYILFNPWCE EDAVYLEN 198 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005576 | extracellular region |
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity |
| GO:0072378 | blood coagulation, fibrin clot formation |
| GO:0018149 | peptide cross-linking |
| Pfam ID | Pfam Term |
|---|---|
| PF00868 | Transglut_N |