CleftGeneDB-Search

Gene: BMP2

Basic information

Tag	Content
Uniprot ID	P12643
Entrez ID	650
Genbank protein ID	AAA51834.1; AAF21646.1;
Genbank nucleotide ID	NM_001200.3
Ensembl protein ID	ENSP00000368104
Ensembl nucleotide ID	ENSG00000125845
Gene name	Bone morphogenetic protein 2
Gene symbol	BMP2
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Sequence	MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAAASSGR PSSQPSDEVL SEFELRLLSM 60 FGLKQRPTPS RDAVVPPYML DLYRRHSGQP GSPAPDHRLE RAASRANTVR SFHHEESLEE 120 LPETSGKTTR RFFFNLSSIP TEEFITSAEL QVFREQMQDA LGNNSSFHHR INIYEIIKPA 180 TANSKFPVTR LLDTRLVNQN ASRWESFDVT PAVMRWTAQG HANHGFVVEV AHLEEKQGVS 240 KRHVRISRSL HQDEHSWSQI RPLLVTFGHD GKGHPLHKRE KRQAKHKQRK RLKSSCKRHP 300 LYVDFSDVGW NDWIVAPPGY HAFYCHGECP FPLADHLNST NHAIVQTLVN SVNSKIPKAC 360 CVPTELSAIS MLYLDENEKV VLKNYQDMVV EGCGCR 396

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1ES7
1REU
1REW
2GOO
2H62
2H64
2QJ9
2QJA
2QJB
3BK3
3BMP
4MID
4N1D
4UHY
4UHZ
4UI0
4UI1
4UI2
6OMN
1REU
2H62
4UI1

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	BMP2	615037	A5PJI9			Bos taurus	Prediction	More>>
1:1 ortholog	BMP2	477162	J9P401			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	BMP2		A0A452EEC2			Capra hircus	Prediction	More>>
1:1 ortholog	BMP2	650	P12643			Homo sapiens	Prediction	More>>
1:1 ortholog	Bmp2	12156	P21274	CPO	E12.5, E13.5, E14.5	Mus musculus	Publication	More>>
1:1 ortholog	BMP2	458090	H2QJY1			Pan troglodytes	Prediction	More>>
1:1 ortholog	BMP2	100157103	A0A286ZZE2			Sus scrofa	Prediction	More>>
1:1 ortholog	BMP2		G1T1R1			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Bmp2		G3V8W4			Rattus norvegicus	Prediction	More>>
1:1 ortholog	bmp2a		B3DI86			Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
RCV000579047	p.Met1Val	missense variant	-	NC_000020.11:g.6770127A>G	ClinVar
rs1332619528	p.Val2Ala	missense variant	-	NC_000020.11:g.6770131T>C	gnomAD
rs867523846	p.Gly4Arg	missense variant	-	NC_000020.11:g.6770136G>A	gnomAD
rs527356831	p.Thr5Ser	missense variant	-	NC_000020.11:g.6770140C>G	1000Genomes,ExAC,gnomAD
rs974052081	p.Arg6His	missense variant	-	NC_000020.11:g.6770143G>A	TOPMed,gnomAD
rs974052081	p.Arg6Pro	missense variant	-	NC_000020.11:g.6770143G>C	TOPMed,gnomAD
rs961599421	p.Arg6Cys	missense variant	-	NC_000020.11:g.6770142C>T	TOPMed,gnomAD
rs1376740838	p.Leu8Phe	missense variant	-	NC_000020.11:g.6770148C>T	TOPMed
rs949067053	p.Ala10Gly	missense variant	-	NC_000020.11:g.6770155C>G	gnomAD
rs769492265	p.Leu11Trp	missense variant	-	NC_000020.11:g.6770158T>G	ExAC,gnomAD
NCI-TCGA novel	p.Pro14Ser	missense variant	-	NC_000020.11:g.6770166C>T	NCI-TCGA
rs1197846053	p.Gln15Ter	stop gained	-	NC_000020.11:g.6770169C>T	gnomAD
RCV000760569	p.Gln15Ter	nonsense	-	NC_000020.11:g.6770169C>T	ClinVar
rs1442853902	p.Gln15His	missense variant	-	NC_000020.11:g.6770171G>C	TOPMed
rs774838556	p.Val16Ile	missense variant	-	NC_000020.11:g.6770172G>A	ExAC,gnomAD
rs1472949182	p.Leu17Phe	missense variant	-	NC_000020.11:g.6770175C>T	gnomAD
rs1362135709	p.Gly19Ala	missense variant	-	NC_000020.11:g.6770182G>C	gnomAD
rs977818261	p.Gly20Ser	missense variant	-	NC_000020.11:g.6770184G>A	TOPMed,gnomAD
rs1187695459	p.Ala21Thr	missense variant	-	NC_000020.11:g.6770187G>A	TOPMed,gnomAD
rs1422558559	p.Gly23Ala	missense variant	-	NC_000020.11:g.6770194G>C	gnomAD
rs763897233	p.Val25Ile	missense variant	-	NC_000020.11:g.6770199G>A	ExAC,gnomAD
rs1304151218	p.Val25Asp	missense variant	-	NC_000020.11:g.6770200T>A	gnomAD
rs774359995	p.Pro26Arg	missense variant	-	NC_000020.11:g.6770203C>G	ExAC,gnomAD
RCV000584741	p.Glu27Ter	nonsense	SHORT STATURE, FACIAL DYSMORPHISM, AND SKELETAL ANOMALIES WITH OR WITHOUT CARDIAC ANOMALIES (SSFSC)	NC_000020.11:g.6770205G>T	ClinVar
rs1555785715	p.Glu27Ter	stop gained	-	NC_000020.11:g.6770205G>T	-
VAR_080742	p.Glu27_Arg396del	inframe_deletion	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies (SSFSC) [MIM:617877]	-	UniProt
rs1266876327	p.Gly29Ser	missense variant	-	NC_000020.11:g.6770211G>A	gnomAD
rs549080609	p.Arg30Cys	missense variant	-	NC_000020.11:g.6770214C>T	1000Genomes
rs1179247089	p.Arg30His	missense variant	-	NC_000020.11:g.6770215G>A	TOPMed
rs796654883	p.Arg31Gly	missense variant	-	NC_000020.11:g.6770217A>G	gnomAD
rs750303403	p.Phe33Leu	missense variant	-	NC_000020.11:g.6770225C>A	ExAC,gnomAD
rs1251797584	p.Ala34Val	missense variant	-	NC_000020.11:g.6770227C>T	NCI-TCGA Cosmic
rs936595058	p.Ala34Pro	missense variant	-	NC_000020.11:g.6770226G>C	gnomAD
rs1251797584	p.Ala34Val	missense variant	-	NC_000020.11:g.6770227C>T	TOPMed
rs755231068	p.Ala35Val	missense variant	-	NC_000020.11:g.6770230C>T	ExAC,gnomAD
rs1418608910	p.Ala36Val	missense variant	-	NC_000020.11:g.6770233C>T	NCI-TCGA
rs752683518	p.Ala36Ser	missense variant	-	NC_000020.11:g.6770232G>T	NCI-TCGA,NCI-TCGA Cosmic
rs1418608910	p.Ala36Val	missense variant	-	NC_000020.11:g.6770233C>T	TOPMed,gnomAD
rs752683518	p.Ala36Ser	missense variant	-	NC_000020.11:g.6770232G>T	ExAC,TOPMed,gnomAD
rs2273073	p.Ser37Ala	missense variant	-	NC_000020.11:g.6770235T>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs2273073	p.Ser37Ala	missense variant	-	NC_000020.11:g.6770235T>G	UniProt,dbSNP
VAR_020061	p.Ser37Ala	missense variant	-	NC_000020.11:g.6770235T>G	UniProt
rs2273073	p.Ser37Pro	missense variant	-	NC_000020.11:g.6770235T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000175687	p.Ser37Ala	missense variant	-	NC_000020.11:g.6770235T>G	ClinVar
COSM1029276	p.Ser37Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6770236C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ser38Trp	missense variant	-	NC_000020.11:g.6770239C>G	NCI-TCGA
rs1442529588	p.Ser38Leu	missense variant	-	NC_000020.11:g.6770239C>T	TOPMed,gnomAD
rs913432818	p.Arg40Gly	missense variant	-	NC_000020.11:g.6770244C>G	TOPMed,gnomAD
rs1431488935	p.Arg40Leu	missense variant	-	NC_000020.11:g.6770245G>T	gnomAD
rs1431488935	p.Arg40His	missense variant	-	NC_000020.11:g.6770245G>A	gnomAD
rs913432818	p.Arg40Cys	missense variant	-	NC_000020.11:g.6770244C>T	TOPMed,gnomAD
NCI-TCGA novel	p.Pro41ArgPheSerTerUnkUnk	frameshift	-	NC_000020.11:g.6770224_6770225insCGCGGCGGCGTCGTCGGGCCGC	NCI-TCGA
NCI-TCGA novel	p.Ser42Ala	missense variant	-	NC_000020.11:g.6770250T>G	NCI-TCGA
rs1043311715	p.Ser43Ala	missense variant	-	NC_000020.11:g.6770253T>G	TOPMed
rs747516210	p.Gln44Glu	missense variant	-	NC_000020.11:g.6770256C>G	ExAC,TOPMed,gnomAD
rs1294143260	p.Gln44His	missense variant	-	NC_000020.11:g.6770258G>T	TOPMed
rs1294143260	p.Gln44His	missense variant	-	NC_000020.11:g.6770258G>T	NCI-TCGA
rs757825179	p.Pro45Thr	missense variant	-	NC_000020.11:g.6770259C>A	ExAC,TOPMed,gnomAD
rs746277910	p.Ser46Thr	missense variant	-	NC_000020.11:g.6770262T>A	ExAC,TOPMed,gnomAD
rs769299110	p.Asp47Glu	missense variant	-	NC_000020.11:g.6770267C>A	ExAC,gnomAD
rs769299110	p.Asp47Glu	missense variant	-	NC_000020.11:g.6770267C>G	ExAC,gnomAD
rs1343341933	p.Glu48Lys	missense variant	-	NC_000020.11:g.6770268G>A	TOPMed,gnomAD
rs1207867223	p.Glu48Asp	missense variant	-	NC_000020.11:g.6770270G>C	gnomAD
rs748698168	p.Ser51Gly	missense variant	-	NC_000020.11:g.6770277A>G	ExAC,gnomAD
rs1180684823	p.Glu52Val	missense variant	-	NC_000020.11:g.6770281A>T	TOPMed
rs1201164661	p.Phe53Leu	missense variant	-	NC_000020.11:g.6770285C>G	gnomAD
rs1272009844	p.Leu55Phe	missense variant	-	NC_000020.11:g.6770291G>T	TOPMed,gnomAD
rs1258528022	p.Arg56Trp	missense variant	-	NC_000020.11:g.6770292C>T	NCI-TCGA
rs890872727	p.Arg56Gln	missense variant	-	NC_000020.11:g.6770293G>A	TOPMed,gnomAD
rs1258528022	p.Arg56Trp	missense variant	-	NC_000020.11:g.6770292C>T	gnomAD
rs773801167	p.Leu58Val	missense variant	-	NC_000020.11:g.6770298C>G	ExAC,TOPMed,gnomAD
rs773801167	p.Leu58Phe	missense variant	-	NC_000020.11:g.6770298C>T	ExAC,TOPMed,gnomAD
rs1008638475	p.Ser59Arg	missense variant	-	NC_000020.11:g.6770303C>A	TOPMed,gnomAD
rs147880089	p.Ser59Gly	missense variant	-	NC_000020.11:g.6770301A>G	ESP,ExAC,TOPMed,gnomAD
rs773113395	p.Met60Leu	missense variant	-	NC_000020.11:g.6770304A>C	ExAC,TOPMed,gnomAD
rs752982363	p.Met60Ile	missense variant	-	NC_000020.11:g.6770306G>T	ExAC,TOPMed,gnomAD
rs557734542	p.Met60Thr	missense variant	-	NC_000020.11:g.6770305T>C	1000Genomes,ExAC,gnomAD
rs773113395	p.Met60Val	missense variant	-	NC_000020.11:g.6770304A>G	ExAC,TOPMed,gnomAD
rs752982363	p.Met60Ile	missense variant	-	NC_000020.11:g.6770306G>A	ExAC,TOPMed,gnomAD
RCV000754562	p.Met60Leu	missense variant	-	NC_000020.11:g.6770304A>C	ClinVar
NCI-TCGA novel	p.Gly62Ser	missense variant	-	NC_000020.11:g.6770310G>A	NCI-TCGA
rs762870450	p.Gln65Leu	missense variant	-	NC_000020.11:g.6770320A>T	ExAC,gnomAD
rs757737368	p.Pro67Ser	missense variant	-	NC_000020.11:g.6770325C>T	ExAC,gnomAD
RCV000733134	p.Pro67Arg	missense variant	-	NC_000020.11:g.6770326C>G	ClinVar
rs995735344	p.Thr68Ile	missense variant	-	NC_000020.11:g.6770329C>T	TOPMed,gnomAD
rs781692600	p.Pro69Ala	missense variant	-	NC_000020.11:g.6770331C>G	ExAC,gnomAD
rs781692600	p.Pro69Ser	missense variant	-	NC_000020.11:g.6770331C>T	ExAC,gnomAD
rs779506433	p.Ala73Thr	missense variant	-	NC_000020.11:g.6770343G>A	ExAC,gnomAD
rs1234611291	p.Ala73Val	missense variant	-	NC_000020.11:g.6770344C>T	gnomAD
rs1460054847	p.Pro76Ser	missense variant	-	NC_000020.11:g.6770352C>T	TOPMed,gnomAD
COSM3693679	p.Pro76Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6770352C>A	NCI-TCGA Cosmic
rs36105541	p.Pro77Ser	missense variant	-	NC_000020.11:g.6770355C>T	TOPMed
rs36105541	p.Pro77Ser	missense variant	-	NC_000020.11:g.6770355C>T	UniProt,dbSNP
VAR_052568	p.Pro77Ser	missense variant	-	NC_000020.11:g.6770355C>T	UniProt
rs151071707	p.Pro77Leu	missense variant	-	NC_000020.11:g.6770356C>T	ESP,ExAC,TOPMed,gnomAD
rs36105541	p.Pro77Ala	missense variant	-	NC_000020.11:g.6770355C>G	TOPMed
rs151071707	p.Pro77Arg	missense variant	-	NC_000020.11:g.6770356C>G	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Tyr78LeuPheSerTerUnkUnk	frameshift	-	NC_000020.11:g.6770351_6770352insC	NCI-TCGA
NCI-TCGA novel	p.Tyr78ThrPheSerTerUnk	frameshift	-	NC_000020.11:g.6770352C>-	NCI-TCGA
rs778541895	p.Met79Ile	missense variant	-	NC_000020.11:g.6770363G>A	ExAC,gnomAD
rs1175971832	p.Tyr83Cys	missense variant	-	NC_000020.11:g.6770374A>G	TOPMed
rs1175971832	p.Tyr83Cys	missense variant	-	NC_000020.11:g.6770374A>G	NCI-TCGA
rs959542332	p.Arg84His	missense variant	-	NC_000020.11:g.6770377G>A	NCI-TCGA Cosmic
rs959542332	p.Arg84His	missense variant	-	NC_000020.11:g.6770377G>A	-
rs369386883	p.Arg85Gly	missense variant	-	NC_000020.11:g.6770379A>G	ESP,ExAC,TOPMed,gnomAD
rs760484979	p.Ser87Leu	missense variant	-	NC_000020.11:g.6770386C>T	ExAC,gnomAD
rs776361118	p.Gly88Asp	missense variant	-	NC_000020.11:g.6770389G>A	ExAC,gnomAD
rs1464127693	p.Gln89Glu	missense variant	-	NC_000020.11:g.6770391C>G	TOPMed
rs1372716317	p.Pro90Thr	missense variant	-	NC_000020.11:g.6770394C>A	TOPMed,gnomAD
rs373345005	p.Gly91Cys	missense variant	-	NC_000020.11:g.6770397G>T	ESP,ExAC,TOPMed,gnomAD
RCV000384219	p.Ser92Leu	missense variant	-	NC_000020.11:g.6770401C>T	ClinVar
rs886043711	p.Ser92Leu	missense variant	-	NC_000020.11:g.6770401C>T	TOPMed,gnomAD
rs779964077	p.Ala94Thr	missense variant	-	NC_000020.11:g.6770406G>A	TOPMed
rs779964077	p.Ala94Ser	missense variant	-	NC_000020.11:g.6770406G>T	TOPMed
rs767964852	p.Ala94Val	missense variant	-	NC_000020.11:g.6770407C>T	ExAC
rs375798188	p.Pro95Ala	missense variant	-	NC_000020.11:g.6770409C>G	ESP,ExAC,TOPMed,gnomAD
rs1387909710	p.Asp96Ala	missense variant	-	NC_000020.11:g.6770413A>C	gnomAD
NCI-TCGA novel	p.His97Asp	missense variant	-	NC_000020.11:g.6770415C>G	NCI-TCGA
rs1321547063	p.His97Gln	missense variant	-	NC_000020.11:g.6770417C>A	gnomAD
rs1285712947	p.His97Arg	missense variant	-	NC_000020.11:g.6770416A>G	gnomAD
rs756645581	p.Arg98Trp	missense variant	-	NC_000020.11:g.6770418C>T	NCI-TCGA,NCI-TCGA Cosmic
rs756645581	p.Arg98Trp	missense variant	-	NC_000020.11:g.6770418C>T	ExAC,TOPMed,gnomAD
rs1269019706	p.Leu99Phe	missense variant	-	NC_000020.11:g.6770423G>T	gnomAD
rs1318885556	p.Glu100Gly	missense variant	-	NC_000020.11:g.6770425A>G	gnomAD
rs780452000	p.Arg101Lys	missense variant	-	NC_000020.11:g.6770428G>A	ExAC,TOPMed,gnomAD
rs1213898222	p.Arg101Gly	missense variant	-	NC_000020.11:g.6770427A>G	gnomAD
rs754203178	p.Ala102Thr	missense variant	-	NC_000020.11:g.6770430G>A	ExAC,gnomAD
rs754625577	p.Ala103Thr	missense variant	-	NC_000020.11:g.6770433G>A	ExAC,TOPMed,gnomAD
rs947607982	p.Ser104Asn	missense variant	-	NC_000020.11:g.6770437G>A	TOPMed
rs1464939104	p.Arg105Gln	missense variant	-	NC_000020.11:g.6770440G>A	TOPMed
rs1182187646	p.Arg105Gly	missense variant	-	NC_000020.11:g.6770439C>G	gnomAD
rs2273074	p.Ala106Thr	missense variant	-	NC_000020.11:g.6770442G>A	UniProt,dbSNP
VAR_020062	p.Ala106Thr	missense variant	-	NC_000020.11:g.6770442G>A	UniProt
rs2273074	p.Ala106Thr	missense variant	-	NC_000020.11:g.6770442G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs978953150	p.Asn107Asp	missense variant	-	NC_000020.11:g.6770445A>G	TOPMed
RCV000368033	p.Thr108Ile	missense variant	-	NC_000020.11:g.6770449C>T	ClinVar
rs374592377	p.Thr108Ile	missense variant	-	NC_000020.11:g.6770449C>T	ExAC,TOPMed,gnomAD
rs771718188	p.Val109Ala	missense variant	-	NC_000020.11:g.6770452T>C	ExAC,gnomAD
rs1345011787	p.Val109Met	missense variant	-	NC_000020.11:g.6770451G>A	gnomAD
rs1345011787	p.Val109Met	missense variant	-	NC_000020.11:g.6770451G>A	NCI-TCGA
NCI-TCGA novel	p.Arg110His	missense variant	-	NC_000020.11:g.6770455G>A	NCI-TCGA
rs746966399	p.His113Tyr	missense variant	-	NC_000020.11:g.6770463C>T	ExAC,TOPMed,gnomAD
rs368974118	p.His114Pro	missense variant	-	NC_000020.11:g.6770467A>C	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu115Gln	missense variant	-	NC_000020.11:g.6770469G>C	NCI-TCGA
NCI-TCGA novel	p.Glu116Ter	stop gained	-	NC_000020.11:g.6770472G>T	NCI-TCGA
COSM3405296	p.Glu119Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778254A>T	NCI-TCGA Cosmic
rs1462426583	p.Glu120Asp	missense variant	-	NC_000020.11:g.6778258A>T	TOPMed,gnomAD
rs757190562	p.Pro122Leu	missense variant	-	NC_000020.11:g.6778263C>T	ExAC,TOPMed,gnomAD
rs1383826535	p.Glu123Lys	missense variant	-	NC_000020.11:g.6778265G>A	gnomAD
rs201118225	p.Thr124Ala	missense variant	-	NC_000020.11:g.6778268A>G	ExAC,TOPMed,gnomAD
rs150153389	p.Thr124Met	missense variant	-	NC_000020.11:g.6778269C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs138635436	p.Ser125Asn	missense variant	-	NC_000020.11:g.6778272G>A	ESP,ExAC,TOPMed,gnomAD
rs1328351508	p.Lys127Glu	missense variant	-	NC_000020.11:g.6778277A>G	TOPMed,gnomAD
rs748356558	p.Thr128Ala	missense variant	-	NC_000020.11:g.6778280A>G	ExAC,gnomAD
rs772329794	p.Arg130Trp	missense variant	-	NC_000020.11:g.6778286C>T	ExAC,TOPMed,gnomAD
rs201927971	p.Arg130Gln	missense variant	-	NC_000020.11:g.6778287G>A	NCI-TCGA,NCI-TCGA Cosmic
rs201927971	p.Arg130Gln	missense variant	-	NC_000020.11:g.6778287G>A	ExAC,TOPMed,gnomAD
rs772329794	p.Arg130Gly	missense variant	-	NC_000020.11:g.6778286C>G	ExAC,TOPMed,gnomAD
COSM5643148	p.Arg130Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778287G>T	NCI-TCGA Cosmic
rs775995068	p.Arg131Ile	missense variant	-	NC_000020.11:g.6778290G>T	ExAC,TOPMed,gnomAD
rs140417301	p.Arg131Ser	missense variant	-	NC_000020.11:g.6778291A>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1206260486	p.Arg131Gly	missense variant	-	NC_000020.11:g.6778289A>G	TOPMed
rs775995068	p.Arg131Ile	missense variant	-	NC_000020.11:g.6778290G>T	NCI-TCGA,NCI-TCGA Cosmic
NCI-TCGA novel	p.Asn135Lys	missense variant	-	NC_000020.11:g.6778303T>G	NCI-TCGA
rs1213913138	p.Ser137Asn	missense variant	-	NC_000020.11:g.6778308G>A	gnomAD
rs759875304	p.Ser137Gly	missense variant	-	NC_000020.11:g.6778307A>G	ExAC,gnomAD
NCI-TCGA novel	p.Ser137Thr	missense variant	-	NC_000020.11:g.6778308G>C	NCI-TCGA
rs765688577	p.Ser138Ala	missense variant	-	NC_000020.11:g.6778310T>G	ExAC,gnomAD
rs544525819	p.Ser138Tyr	missense variant	-	NC_000020.11:g.6778311C>A	1000Genomes,ExAC,gnomAD
rs544525819	p.Ser138Tyr	missense variant	-	NC_000020.11:g.6778311C>A	NCI-TCGA
rs758105707	p.Ile139Val	missense variant	-	NC_000020.11:g.6778313A>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro140Ser	missense variant	-	NC_000020.11:g.6778316C>T	NCI-TCGA
NCI-TCGA novel	p.Thr141ArgPheSerTerUnkUnk	frameshift	-	NC_000020.11:g.6778315C>-	NCI-TCGA
rs763882274	p.Thr141Met	missense variant	-	NC_000020.11:g.6778320C>T	ExAC,TOPMed,gnomAD
COSM1413274	p.Thr141HisPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000020.11:g.6778314_6778315insC	NCI-TCGA Cosmic
NCI-TCGA novel	p.Glu142Asp	missense variant	-	NC_000020.11:g.6778324G>T	NCI-TCGA
rs756741663	p.Phe144Ser	missense variant	-	NC_000020.11:g.6778329T>C	ExAC,TOPMed,gnomAD
rs868184167	p.Thr146Ile	missense variant	-	NC_000020.11:g.6778335C>T	TOPMed
rs868184167	p.Thr146Asn	missense variant	-	NC_000020.11:g.6778335C>A	TOPMed
NCI-TCGA novel	p.Ser147Leu	missense variant	-	NC_000020.11:g.6778338C>T	NCI-TCGA
rs1201322291	p.Gln151His	missense variant	-	NC_000020.11:g.6778351G>C	TOPMed,gnomAD
COSM4902027	p.Gln151Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000020.11:g.6778349C>T	NCI-TCGA Cosmic
rs1167821863	p.Phe153Ser	missense variant	-	NC_000020.11:g.6778356T>C	gnomAD
rs1057523275	p.Arg154Ter	stop gained	-	NC_000020.11:g.6778358C>T	-
RCV000755726	p.Arg154Ter	nonsense	SHORT STATURE, FACIAL DYSMORPHISM, AND SKELETAL ANOMALIES WITH OR WITHOUT CARDIAC ANOMALIES (SSFSC)	NC_000020.11:g.6778358C>T	ClinVar
rs111675841	p.Arg154Gln	missense variant	-	NC_000020.11:g.6778359G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
VAR_080743	p.Arg154_Arg396del	inframe_deletion	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies (SSFSC) [MIM:617877]	-	UniProt
COSM1029280	p.Glu155Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000020.11:g.6778361G>T	NCI-TCGA Cosmic
rs200735108	p.Gln156Glu	missense variant	-	NC_000020.11:g.6778364C>G	1000Genomes,TOPMed,gnomAD
rs779801820	p.Asp159Ala	missense variant	-	NC_000020.11:g.6778374A>C	ExAC,gnomAD
rs1435548167	p.Ala160Val	missense variant	-	NC_000020.11:g.6778377C>T	gnomAD
rs1435548167	p.Ala160Asp	missense variant	-	NC_000020.11:g.6778377C>A	gnomAD
rs34183594	p.Leu161Ser	missense variant	-	NC_000020.11:g.6778380T>C	UniProt,dbSNP
VAR_052569	p.Leu161Ser	missense variant	-	NC_000020.11:g.6778380T>C	UniProt
rs34183594	p.Leu161Ser	missense variant	-	NC_000020.11:g.6778380T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs953712707	p.Asn164Asp	missense variant	-	NC_000020.11:g.6778388A>G	TOPMed
rs773326826	p.Asn164Ser	missense variant	-	NC_000020.11:g.6778389A>G	ExAC,gnomAD
rs1188623371	p.Ser165Gly	missense variant	-	NC_000020.11:g.6778391A>G	TOPMed
rs1188623371	p.Ser165Gly	missense variant	-	NC_000020.11:g.6778391A>G	NCI-TCGA
COSM1029281	p.Ser166Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778395G>A	NCI-TCGA Cosmic
COSM6094030	p.Phe167Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778399C>G	NCI-TCGA Cosmic
rs373168490	p.His168Asn	missense variant	-	NC_000020.11:g.6778400C>A	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.His169Tyr	missense variant	-	NC_000020.11:g.6778403C>T	NCI-TCGA
rs776834114	p.Arg170Gln	missense variant	-	NC_000020.11:g.6778407G>A	ExAC,TOPMed,gnomAD
rs776834114	p.Arg170Gln	missense variant	-	NC_000020.11:g.6778407G>A	NCI-TCGA,NCI-TCGA Cosmic
rs1262129418	p.Asn172Ser	missense variant	-	NC_000020.11:g.6778413A>G	gnomAD
rs1329513102	p.Ile173Val	missense variant	-	NC_000020.11:g.6778415A>G	gnomAD
rs1206516663	p.Ile173Ser	missense variant	-	NC_000020.11:g.6778416T>G	gnomAD
rs1286844558	p.Ile176Met	missense variant	-	NC_000020.11:g.6778426C>G	gnomAD
rs760111045	p.Ile177Leu	missense variant	-	NC_000020.11:g.6778427A>C	ExAC,TOPMed,gnomAD
rs527355069	p.Pro179Leu	missense variant	-	NC_000020.11:g.6778434C>T	1000Genomes,ExAC,gnomAD
rs775969696	p.Ala180Val	missense variant	-	NC_000020.11:g.6778437C>T	ExAC,gnomAD
rs763444779	p.Thr181Ile	missense variant	-	NC_000020.11:g.6778440C>T	ExAC,gnomAD
rs549080568	p.Ser184Trp	missense variant	-	NC_000020.11:g.6778449C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs549080568	p.Ser184Leu	missense variant	-	NC_000020.11:g.6778449C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs749999118	p.Lys185Arg	missense variant	-	NC_000020.11:g.6778452A>G	ExAC,gnomAD
rs756013012	p.Phe186Leu	missense variant	-	NC_000020.11:g.6778454T>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro187Leu	missense variant	-	NC_000020.11:g.6778458C>T	NCI-TCGA
rs551304949	p.Val188Met	missense variant	-	NC_000020.11:g.6778460G>A	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Thr189Pro	missense variant	-	NC_000020.11:g.6778463A>C	NCI-TCGA
rs235768	p.Arg190Ser	missense variant	-	NC_000020.11:g.6778468A>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs984032782	p.Arg190Lys	missense variant	-	NC_000020.11:g.6778467G>A	TOPMed
RCV000177127	p.Arg190Ser	missense variant	-	NC_000020.11:g.6778468A>T	ClinVar
rs180897623	p.Val197Leu	missense variant	-	NC_000020.11:g.6778487G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs180897623	p.Val197Met	missense variant	-	NC_000020.11:g.6778487G>A	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gln199Ter	stop gained	-	NC_000020.11:g.6778493C>T	NCI-TCGA
rs1349011153	p.Asn200Lys	missense variant	-	NC_000020.11:g.6778498T>A	gnomAD
rs148232300	p.Ser202Gly	missense variant	-	NC_000020.11:g.6778502A>G	ESP,ExAC,gnomAD
rs776166057	p.Arg203Ser	missense variant	-	NC_000020.11:g.6778507G>T	ExAC,TOPMed,gnomAD
rs770387804	p.Arg203Lys	missense variant	-	NC_000020.11:g.6778506G>A	ExAC,gnomAD
COSM4911529	p.Arg203Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778506G>T	NCI-TCGA Cosmic
rs1325090264	p.Trp204Arg	missense variant	-	NC_000020.11:g.6778508T>C	gnomAD
rs1343299915	p.Ser206Asn	missense variant	-	NC_000020.11:g.6778515G>A	TOPMed,gnomAD
rs768908839	p.Asp208Val	missense variant	-	NC_000020.11:g.6778521A>T	ExAC,gnomAD
rs937303269	p.Thr210Ile	missense variant	-	NC_000020.11:g.6778527C>T	TOPMed,gnomAD
NCI-TCGA novel	p.Pro211Thr	missense variant	-	NC_000020.11:g.6778529C>A	NCI-TCGA
rs1410843089	p.Pro211Arg	missense variant	-	NC_000020.11:g.6778530C>G	TOPMed
NCI-TCGA novel	p.Ala212LeuPheSerTerUnk	frameshift	-	NC_000020.11:g.6778527C>-	NCI-TCGA
rs377749107	p.Ala212Thr	missense variant	-	NC_000020.11:g.6778532G>A	ESP,ExAC,gnomAD
rs377749107	p.Ala212Pro	missense variant	-	NC_000020.11:g.6778532G>C	ESP,ExAC,gnomAD
rs1422724017	p.Met214Val	missense variant	-	NC_000020.11:g.6778538A>G	gnomAD
rs755006479	p.Met214Ile	missense variant	-	NC_000020.11:g.6778540G>A	ExAC,gnomAD
NCI-TCGA novel	p.Arg215Trp	missense variant	-	NC_000020.11:g.6778541C>T	NCI-TCGA
rs141178075	p.Arg215Gln	missense variant	-	NC_000020.11:g.6778542G>A	ESP,ExAC,TOPMed,gnomAD
rs895863242	p.Trp216Cys	missense variant	-	NC_000020.11:g.6778546G>C	TOPMed
rs1326461703	p.Ala218Val	missense variant	-	NC_000020.11:g.6778551C>T	gnomAD
rs371085275	p.Ala218Thr	missense variant	-	NC_000020.11:g.6778550G>A	ESP,ExAC,gnomAD
rs868190033	p.Gly220Val	missense variant	-	NC_000020.11:g.6778557G>T	gnomAD
rs868190033	p.Gly220Glu	missense variant	-	NC_000020.11:g.6778557G>A	gnomAD
rs1182413674	p.His221Arg	missense variant	-	NC_000020.11:g.6778560A>G	TOPMed
rs140884062	p.Ala222Thr	missense variant	-	NC_000020.11:g.6778562G>A	NCI-TCGA,NCI-TCGA Cosmic
rs140884062	p.Ala222Thr	missense variant	-	NC_000020.11:g.6778562G>A	ESP,ExAC,TOPMed,gnomAD
rs1291634218	p.Ala222Gly	missense variant	-	NC_000020.11:g.6778563C>G	gnomAD
rs745897492	p.Asn223Ser	missense variant	-	NC_000020.11:g.6778566A>G	ExAC,gnomAD
NCI-TCGA novel	p.His224Asn	missense variant	-	NC_000020.11:g.6778568C>A	NCI-TCGA
rs267606060	p.Gly225Arg	missense variant	-	NC_000020.11:g.6778571G>A	NCI-TCGA,NCI-TCGA Cosmic
NCI-TCGA novel	p.Gly225Glu	missense variant	-	NC_000020.11:g.6778572G>A	NCI-TCGA
rs267606060	p.Gly225Arg	missense variant	-	NC_000020.11:g.6778571G>A	-
rs780643020	p.Val227Leu	missense variant	-	NC_000020.11:g.6778577G>C	ExAC,TOPMed,gnomAD
rs780643020	p.Val227Met	missense variant	-	NC_000020.11:g.6778577G>A	ExAC,TOPMed,gnomAD
rs780643020	p.Val227Met	missense variant	-	NC_000020.11:g.6778577G>A	NCI-TCGA,NCI-TCGA Cosmic
rs774548159	p.Val228Ala	missense variant	-	NC_000020.11:g.6778581T>C	ExAC,TOPMed,gnomAD
rs769264233	p.Val228Leu	missense variant	-	NC_000020.11:g.6778580G>T	ExAC,TOPMed,gnomAD
COSM4100660	p.Ala231Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778589G>T	NCI-TCGA Cosmic
rs756991680	p.His232Leu	missense variant	-	NC_000020.11:g.6778593A>T	ExAC,TOPMed,gnomAD
rs1463073209	p.Leu233Val	missense variant	-	NC_000020.11:g.6778595T>G	gnomAD
rs1395477404	p.Glu234Gly	missense variant	-	NC_000020.11:g.6778599A>G	TOPMed
rs1296012081	p.Glu235Asp	missense variant	-	NC_000020.11:g.6778603G>C	TOPMed,gnomAD
rs1296012081	p.Glu235Asp	missense variant	-	NC_000020.11:g.6778603G>T	TOPMed,gnomAD
rs143336052	p.Gln237Arg	missense variant	-	NC_000020.11:g.6778608A>G	ESP,ExAC,TOPMed,gnomAD
rs1338256000	p.Gly238Ala	missense variant	-	NC_000020.11:g.6778611G>C	gnomAD
rs1443406422	p.Gly238Ser	missense variant	-	NC_000020.11:g.6778610G>A	TOPMed
rs1450842847	p.Lys241Thr	missense variant	-	NC_000020.11:g.6778620A>C	gnomAD
rs1370398615	p.Lys241Asn	missense variant	-	NC_000020.11:g.6778621G>C	TOPMed
NCI-TCGA novel	p.Val244LeuPheSerTerUnk	frameshift	-	NC_000020.11:g.6778628G>-	NCI-TCGA
rs1312646092	p.Arg245Lys	missense variant	-	NC_000020.11:g.6778632G>A	gnomAD
rs760108003	p.His251Asp	missense variant	-	NC_000020.11:g.6778649C>G	ExAC,gnomAD
COSM3911865	p.Gln252Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000020.11:g.6778652C>T	NCI-TCGA Cosmic
rs776172632	p.Asp253Tyr	missense variant	-	NC_000020.11:g.6778655G>T	ExAC,gnomAD
rs759365542	p.His255Gln	missense variant	-	NC_000020.11:g.6778663C>G	ExAC,gnomAD
rs1204582570	p.Ser256Gly	missense variant	-	NC_000020.11:g.6778664A>G	gnomAD
rs1204582570	p.Ser256Arg	missense variant	-	NC_000020.11:g.6778664A>C	gnomAD
rs375357102	p.Trp257Cys	missense variant	-	NC_000020.11:g.6778669G>T	ESP,ExAC,gnomAD
rs1245145872	p.Trp257Leu	missense variant	-	NC_000020.11:g.6778668G>T	gnomAD
rs1182679355	p.Ser258Pro	missense variant	-	NC_000020.11:g.6778670T>C	gnomAD
rs1167099474	p.Ile260Lys	missense variant	-	NC_000020.11:g.6778677T>A	TOPMed
COSM4100661	p.Ile260Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778676A>G	NCI-TCGA Cosmic
rs199628088	p.Leu263Ser	missense variant	-	NC_000020.11:g.6778686T>C	1000Genomes,ExAC,TOPMed,gnomAD
rs758237738	p.Leu263Met	missense variant	-	NC_000020.11:g.6778685T>A	ExAC,gnomAD
rs750679612	p.Leu263Phe	missense variant	-	NC_000020.11:g.6778687G>T	ExAC,gnomAD
rs756473236	p.Thr266Ile	missense variant	-	NC_000020.11:g.6778695C>T	ExAC,gnomAD
rs749429499	p.Phe267Ser	missense variant	-	NC_000020.11:g.6778698T>C	ExAC,gnomAD
rs191265322	p.His269Arg	missense variant	-	NC_000020.11:g.6778704A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs755398280	p.His269Tyr	missense variant	-	NC_000020.11:g.6778703C>T	ExAC,TOPMed,gnomAD
rs748402055	p.Asp270Gly	missense variant	-	NC_000020.11:g.6778707A>G	ExAC,gnomAD
NCI-TCGA novel	p.Asp270GluPheSerTerUnkUnk	frameshift	-	NC_000020.11:g.6778708T>-	NCI-TCGA
rs772487751	p.Gly271Arg	missense variant	-	NC_000020.11:g.6778709G>A	ExAC,gnomAD
rs1369599288	p.Leu276Phe	missense variant	-	NC_000020.11:g.6778724C>T	TOPMed,gnomAD
NCI-TCGA novel	p.His277Asn	missense variant	-	NC_000020.11:g.6778727C>A	NCI-TCGA
rs368389739	p.His277Arg	missense variant	-	NC_000020.11:g.6778728A>G	ESP,TOPMed
NCI-TCGA novel	p.Glu280Ter	stop gained	-	NC_000020.11:g.6778736G>T	NCI-TCGA
rs773630680	p.Arg282His	missense variant	-	NC_000020.11:g.6778743G>A	ExAC,TOPMed,gnomAD
rs904649778	p.Arg282Cys	missense variant	-	NC_000020.11:g.6778742C>T	TOPMed
rs1224137887	p.Gln283His	missense variant	-	NC_000020.11:g.6778747A>C	gnomAD
rs746647623	p.Ala284Val	missense variant	-	NC_000020.11:g.6778749C>T	ExAC,gnomAD
COSM4900011	p.Lys285Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778751A>G	NCI-TCGA Cosmic
rs1459743085	p.Gln288Glu	missense variant	-	NC_000020.11:g.6778760C>G	gnomAD
rs770615288	p.Arg289Trp	missense variant	-	NC_000020.11:g.6778763C>T	ExAC,TOPMed,gnomAD
rs370948498	p.Arg289Gln	missense variant	-	NC_000020.11:g.6778764G>A	ESP,ExAC,TOPMed,gnomAD
rs370948498	p.Arg289Gln	missense variant	-	NC_000020.11:g.6778764G>A	NCI-TCGA,NCI-TCGA Cosmic
rs765038230	p.Arg291His	missense variant	-	NC_000020.11:g.6778770G>A	ExAC,TOPMed,gnomAD
rs759121274	p.Arg291Cys	missense variant	-	NC_000020.11:g.6778769C>T	ExAC,TOPMed,gnomAD
rs759121274	p.Arg291Cys	missense variant	-	NC_000020.11:g.6778769C>T	NCI-TCGA,NCI-TCGA Cosmic
rs775514883	p.Lys293Arg	missense variant	-	NC_000020.11:g.6778776A>G	ExAC,gnomAD
rs1260895456	p.Lys293Gln	missense variant	-	NC_000020.11:g.6778775A>C	gnomAD
COSM3549304	p.Lys293Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778776A>C	NCI-TCGA Cosmic
rs763978335	p.Lys297Gln	missense variant	-	NC_000020.11:g.6778787A>C	ExAC
COSM3841578	p.Lys297Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778789G>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Arg298Ile	missense variant	-	NC_000020.11:g.6778791G>T	NCI-TCGA
rs756383266	p.Arg298Lys	missense variant	-	NC_000020.11:g.6778791G>A	ExAC,gnomAD
rs1407101620	p.His299Arg	missense variant	-	NC_000020.11:g.6778794A>G	TOPMed
rs753811841	p.His299Gln	missense variant	-	NC_000020.11:g.6778795C>A	ExAC,gnomAD
rs1287645995	p.Pro300Leu	missense variant	-	NC_000020.11:g.6778797C>T	gnomAD
rs1455627279	p.Pro300Thr	missense variant	-	NC_000020.11:g.6778796C>A	gnomAD
rs779219938	p.Val303Met	missense variant	-	NC_000020.11:g.6778805G>A	ExAC,gnomAD
rs1343693799	p.Asp307Gly	missense variant	-	NC_000020.11:g.6778818A>G	gnomAD
rs758959332	p.Val308Met	missense variant	-	NC_000020.11:g.6778820G>A	ExAC,TOPMed,gnomAD
rs758959332	p.Val308Met	missense variant	-	NC_000020.11:g.6778820G>A	NCI-TCGA,NCI-TCGA Cosmic
rs867664596	p.Trp313Ter	stop gained	-	NC_000020.11:g.6778836G>A	-
rs867664596	p.Trp313Ter	stop gained	-	NC_000020.11:g.6778836G>A	NCI-TCGA
NCI-TCGA novel	p.Ala316Val	missense variant	-	NC_000020.11:g.6778845C>T	NCI-TCGA
COSM3549305	p.Pro317Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778847C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Pro318ArgPheSerTerUnkUnk	frameshift	-	NC_000020.11:g.6778847C>-	NCI-TCGA
rs1472087975	p.Pro318Leu	missense variant	-	NC_000020.11:g.6778851C>T	TOPMed
RCV000584732	p.Tyr320Ter	frameshift	SHORT STATURE, FACIAL DYSMORPHISM, AND SKELETAL ANOMALIES WITH OR WITHOUT CARDIAC ANOMALIES (SSFSC)	NC_000020.11:g.6778851dup	ClinVar
rs1490510739	p.Tyr320Asp	missense variant	-	NC_000020.11:g.6778856T>G	gnomAD
NCI-TCGA novel	p.His321Asp	missense variant	-	NC_000020.11:g.6778859C>G	NCI-TCGA
rs1266204708	p.Ala322Ser	missense variant	-	NC_000020.11:g.6778862G>T	gnomAD
NCI-TCGA novel	p.Ala322Thr	missense variant	-	NC_000020.11:g.6778862G>A	NCI-TCGA
rs1177449473	p.Phe323Leu	missense variant	-	NC_000020.11:g.6778867T>A	gnomAD
rs1421256768	p.His326Tyr	missense variant	-	NC_000020.11:g.6778874C>T	gnomAD
rs190569855	p.Gly327Arg	missense variant	-	NC_000020.11:g.6778877G>A	NCI-TCGA,NCI-TCGA Cosmic
rs190569855	p.Gly327Arg	missense variant	-	NC_000020.11:g.6778877G>A	1000Genomes
RCV000584742	p.Cys329Ter	nonsense	SHORT STATURE, FACIAL DYSMORPHISM, AND SKELETAL ANOMALIES WITH OR WITHOUT CARDIAC ANOMALIES (SSFSC)	NC_000020.11:g.6778885C>A	ClinVar
rs1555786156	p.Cys329Ter	stop gained	-	NC_000020.11:g.6778885C>A	-
VAR_080744	p.Cys329_Arg396del	inframe_deletion	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies (SSFSC) [MIM:617877]	-	UniProt
COSM3549306	p.Pro332Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778892C>T	NCI-TCGA Cosmic
rs1425902138	p.Asn338Ser	missense variant	-	NC_000020.11:g.6778911A>G	gnomAD
NCI-TCGA novel	p.Thr340Ala	missense variant	-	NC_000020.11:g.6778916A>G	NCI-TCGA
NCI-TCGA novel	p.Ala343Asp	missense variant	-	NC_000020.11:g.6778926C>A	NCI-TCGA
rs145193697	p.Ile344Val	missense variant	-	NC_000020.11:g.6778928A>G	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Val345Ala	missense variant	-	NC_000020.11:g.6778932T>C	NCI-TCGA
COSM444260	p.Gln346Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000020.11:g.6778934C>T	NCI-TCGA Cosmic
COSM3549307	p.Gln346His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778936G>C	NCI-TCGA Cosmic
rs148745143	p.Thr347Met	missense variant	-	NC_000020.11:g.6778938C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs768764091	p.Lys358Arg	missense variant	-	NC_000020.11:g.6778971A>G	ExAC,gnomAD
rs1216567359	p.Lys358Asn	missense variant	-	NC_000020.11:g.6778972G>C	TOPMed
COSM4100663	p.Ala359Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6778973G>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Cys361Gly	missense variant	-	NC_000020.11:g.6778979T>G	NCI-TCGA
rs1359852562	p.Cys361Tyr	missense variant	-	NC_000020.11:g.6778980G>A	gnomAD
rs553834050	p.Val362Ile	missense variant	-	NC_000020.11:g.6778982G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1289444520	p.Pro363Leu	missense variant	-	NC_000020.11:g.6778986C>T	gnomAD
rs1225746483	p.Thr364Ile	missense variant	-	NC_000020.11:g.6778989C>T	TOPMed
rs766649989	p.Glu365Gly	missense variant	-	NC_000020.11:g.6778992A>G	ExAC,gnomAD
NCI-TCGA novel	p.Glu365Ter	stop gained	-	NC_000020.11:g.6778991G>T	NCI-TCGA
NCI-TCGA novel	p.Ala368Val	missense variant	-	NC_000020.11:g.6779001C>T	NCI-TCGA
rs1445570003	p.Ile369Val	missense variant	-	NC_000020.11:g.6779003A>G	gnomAD
rs200531184	p.Glu376Asp	missense variant	-	NC_000020.11:g.6779026G>C	ExAC,gnomAD
rs1356335204	p.Glu376Lys	missense variant	-	NC_000020.11:g.6779024G>A	gnomAD
rs751876723	p.Asn377Ser	missense variant	-	NC_000020.11:g.6779028A>G	ExAC,gnomAD
COSM3549308	p.Glu378Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6779030G>A	NCI-TCGA Cosmic
rs757635021	p.Lys383Arg	missense variant	-	NC_000020.11:g.6779046A>G	ExAC,gnomAD
COSM259647	p.Lys383Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.6779047G>T	NCI-TCGA Cosmic
rs140326695	p.Asn384Ser	missense variant	-	NC_000020.11:g.6779049A>G	ESP,ExAC,TOPMed,gnomAD
rs1305226244	p.Val389Gly	missense variant	-	NC_000020.11:g.6779064T>G	gnomAD
rs779593991	p.Gly392Ser	missense variant	-	NC_000020.11:g.6779072G>A	ExAC,gnomAD
rs779593991	p.Gly392Cys	missense variant	-	NC_000020.11:g.6779072G>T	ExAC,gnomAD
rs151019338	p.Arg396His	missense variant	-	NC_000020.11:g.6779085G>A	ESP,ExAC,TOPMed,gnomAD
rs774442750	p.Arg396Cys	missense variant	-	NC_000020.11:g.6779084C>T	ExAC,gnomAD
rs151019338	p.Arg396Leu	missense variant	-	NC_000020.11:g.6779085G>T	ESP,ExAC,TOPMed,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0000768	Congenital Abnormality	group	BEFREE
C0001418	Adenocarcinoma	group	BEFREE
C0001618	Tumors of Adrenal Cortex	group	BEFREE
C0002793	Anaplasia	disease	BEFREE
C0002986	Fabry Disease	disease	BEFREE
C0003850	Arteriosclerosis	disease	BEFREE
C0003864	Arthritis	disease	BEFREE
C0003873	Rheumatoid Arthritis	disease	BEFREE
C0004153	Atherosclerosis	disease	BEFREE
C0004364	Autoimmune Diseases	group	BEFREE
C0004997	Benign Ovarian Neoplasm	disease	BEFREE
C0005940	Bone Diseases	group	CTD_human
C0006142	Malignant neoplasm of breast	disease	BEFREE;CTD_human
C0006386	Bunion	phenotype	HPO
C0006826	Malignant Neoplasms	group	BEFREE
C0007102	Malignant tumor of colon	disease	BEFREE
C0007113	Rectal Carcinoma	disease	BEFREE
C0007117	Basal cell carcinoma	disease	LHGDN
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE
C0007134	Renal Cell Carcinoma	disease	BEFREE
C0007137	Squamous cell carcinoma	disease	BEFREE
C0008441	Chondroblastoma	disease	BEFREE
C0008479	Chondrosarcoma	disease	BEFREE;LHGDN
C0008495	Chorioamnionitis	phenotype	LHGDN
C0008925	Cleft Palate	disease	BEFREE
C0009241	Cognition Disorders	group	BEFREE
C0009402	Colorectal Carcinoma	disease	BEFREE
C0009404	Colorectal Neoplasms	group	LHGDN
C0010054	Coronary Arteriosclerosis	disease	BEFREE
C0010278	Craniosynostosis	disease	BEFREE;CTD_human
C0011854	Diabetes Mellitus, Insulin-Dependent	disease	BEFREE
C0011881	Diabetic Nephropathy	disease	BEFREE
C0014145	Yolk Sac Tumor	disease	BEFREE
C0016658	Fracture	group	CTD_human
C0017636	Glioblastoma	disease	BEFREE
C0018536	Hallux Valgus	phenotype	HPO
C0018824	Heart valve disease	group	BEFREE
C0018995	Hemochromatosis	disease	CTD_human
C0019159	Hepatitis A	disease	BEFREE
C0019348	Herpes Simplex Infections	group	BEFREE
C0020534	Orbital separation excessive	phenotype	HPO
C0020538	Hypertensive disease	group	BEFREE
C0020542	Pulmonary Hypertension	phenotype	LHGDN
C0020635	Hypopituitarism	disease	BEFREE
C0021051	Immunologic Deficiency Syndromes	group	BEFREE
C0022660	Kidney Failure, Acute	disease	BEFREE
C0022876	Premature Obstetric Labor	phenotype	BEFREE
C0023267	Fibroid Tumor	group	BEFREE
C0023474	Leukemia, Myeloid, Chronic-Phase	disease	BEFREE
C0023487	Acute Promyelocytic Leukemia	disease	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE;CTD_human
C0025149	Medulloblastoma	disease	BEFREE
C0025500	Mesothelioma	disease	BEFREE
C0026034	Microstomia	disease	HPO
C0026277	Mixed Salivary Gland Tumor	disease	BEFREE
C0026764	Multiple Myeloma	disease	BEFREE
C0026769	Multiple Sclerosis	disease	BEFREE
C0026837	Muscle Rigidity	phenotype	BEFREE
C0026936	Mycoplasma Infections	group	BEFREE
C0027092	Myopia	disease	BEFREE;CTD_human
C0027627	Neoplasm Metastasis	phenotype	BEFREE;LHGDN
C0027651	Neoplasms	group	BEFREE
C0027708	Nephroblastoma	disease	BEFREE
C0027809	Neurilemmoma	disease	LHGDN
C0027819	Neuroblastoma	group	BEFREE
C0027831	Neurofibromatosis 1	disease	BEFREE
C0028259	Nodule	phenotype	BEFREE
C0029408	Degenerative polyarthritis	disease	BEFREE
C0029422	Osteochondrodysplasias	group	BEFREE
C0029423	Cartilaginous exostosis	disease	BEFREE
C0029453	Osteopenia	disease	BEFREE
C0029456	Osteoporosis	disease	BEFREE;LHGDN
C0029463	Osteosarcoma	disease	BEFREE;LHGDN
C0029899	Otosclerosis	disease	BEFREE;LHGDN
C0029925	Ovarian Carcinoma	disease	BEFREE
C0030044	Acrocephaly	disease	CTD_human
C0032915	Preexcitation Syndrome	disease	BEFREE
C0033578	Prostatic Neoplasms	group	LHGDN
C0035412	Rhabdomyosarcoma	disease	BEFREE
C0035851	Root Resorption	disease	BEFREE
C0035934	Rubinstein-Taybi Syndrome	disease	BEFREE
C0036631	Seminoma	disease	BEFREE
C0038013	Ankylosing spondylitis	disease	BEFREE
C0038356	Stomach Neoplasms	group	BEFREE;CTD_human
C0039075	Syndactyly	disease	BEFREE
C0040100	Thymoma	disease	BEFREE
C0041948	Uremia	disease	CTD_human
C0041956	Ureteral obstruction	phenotype	BEFREE
C0042133	Uterine Fibroids	group	BEFREE
C0043202	Wolff-Parkinson-White Syndrome	disease	BEFREE;HPO
C0079588	Ichthyosis, X-Linked	disease	BEFREE
C0151744	Myocardial Ischemia	disease	BEFREE
C0152013	Adenocarcinoma of lung (disorder)	disease	BEFREE
C0152171	Idiopathic pulmonary hypertension	disease	BEFREE
C0153690	Secondary malignant neoplasm of bone	disease	BEFREE
C0158252	Intervertebral disc disorder	group	BEFREE
C0158266	Intervertebral Disc Degeneration	disease	BEFREE
C0162316	Iron deficiency anemia	disease	BEFREE
C0178874	Tumor Progression	phenotype	BEFREE
C0206659	Embryonal Carcinoma	disease	BEFREE
C0206686	Adrenocortical carcinoma	disease	BEFREE
C0206695	Carcinoma, Neuroendocrine	group	BEFREE
C0206711	Pilomatrixoma	disease	BEFREE
C0220620	Gastrointestinal Carcinoid Tumor	disease	BEFREE
C0221356	Brachycephaly	disease	CTD_human
C0234958	Muscle degeneration	disease	BEFREE
C0235974	Pancreatic carcinoma	disease	BEFREE
C0235989	Renal interstitial fibrosis	disease	BEFREE
C0240310	Hypoplasia of the maxilla	disease	HPO
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0265534	Scaphycephaly	disease	CTD_human
C0265535	Trigonocephaly	disease	CTD_human
C0271561	Somatotropin deficiency	disease	BEFREE
C0278488	Carcinoma breast stage IV	disease	BEFREE
C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	disease	BEFREE
C0332712	Fracture, spiral	disease	CTD_human
C0338656	Impaired cognition	disease	BEFREE
C0345893	Juvenile polyposis syndrome	disease	BEFREE
C0345904	Malignant neoplasm of liver	disease	BEFREE
C0345963	Benign neoplasm of lung	disease	BEFREE
C0345967	Malignant mesothelioma	disease	BEFREE
C0346647	Malignant neoplasm of pancreas	disease	BEFREE
C0349588	Short stature	phenotype	HPO
C0376154	Skin callus	phenotype	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0392514	Hereditary hemochromatosis	disease	CTD_human
C0409952	Idiopathic osteoarthritis	disease	BEFREE
C0410528	Skeletal dysplasia	disease	BEFREE
C0423110	Downward slant of palpebral fissure	phenotype	HPO
C0432040	Simple syndactyly of toes, first web space	disease	HPO
C0432072	Dysmorphic features	disease	BEFREE
C0432123	Sagittal craniosynostosis	disease	BEFREE
C0521857	Increased drug resistance	phenotype	BEFREE
C0557874	Global developmental delay	disease	HPO
C0585442	Osteosarcoma of bone	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0598935	Tumor Initiation	phenotype	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0677886	Epithelial ovarian cancer	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE;CTD_human
C0678230	Congenital Epicanthus	disease	HPO
C0684249	Carcinoma of lung	disease	BEFREE
C0686619	Secondary malignant neoplasm of lymph node	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0700095	Central neuroblastoma	disease	BEFREE
C0730328	Central Serous Chorioretinopathy	disease	BEFREE
C0751690	Malignant Peripheral Nerve Sheath Tumor	disease	BEFREE
C0812437	Oculo-dento-digital syndrome	disease	BEFREE
C0850666	Infection caused by Helicobacter pylori	disease	BEFREE
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1257931	Mammary Neoplasms, Human	group	CTD_human
C1261473	Sarcoma	group	BEFREE
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1332986	Childhood Osteosarcoma	disease	BEFREE
C1335302	Pancreatic Ductal Adenocarcinoma	disease	BEFREE
C1384584	Generalized osteoarthritis	disease	BEFREE
C1458155	Mammary Neoplasms	group	BEFREE;CTD_human;LHGDN
C1527249	Colorectal Cancer	disease	BEFREE
C1561643	Chronic Kidney Diseases	group	BEFREE
C1621958	Glioblastoma Multiforme	disease	BEFREE
C1704272	Benign Prostatic Hyperplasia	disease	BEFREE
C1704436	Peripheral Arterial Diseases	group	BEFREE;CTD_human
C1708349	Hereditary Diffuse Gastric Cancer	disease	CTD_human
C1832702	BRACHYDACTYLY, TYPE A2	disease	BEFREE;CTD_human;HPO;ORPHANET
C1833340	Synostotic Posterior Plagiocephaly	disease	CTD_human
C1834034	Aplasia/Hypoplasia of the middle phalanx of the 5th finger	phenotype	HPO
C1834060	Short middle phalanx of the 5th finger	phenotype	HPO
C1837218	Cleft palate, isolated	disease	BEFREE
C1844709	Radial deviation of the 2nd finger	phenotype	HPO
C1844891	Ulnar deviation of the 2nd finger	phenotype	HPO
C1848673	Hypoplastic feet	phenotype	HPO
C1850049	Clinodactyly of the 5th finger	disease	HPO
C1858085	Malar flattening	phenotype	HPO
C1860819	Metopic synostosis	disease	CTD_human
C1862140	Brachydactyly type A3	disease	HPO
C1862142	Short 2nd finger	phenotype	HPO
C1862144	Aplasia/Hypoplasia of the middle phalanx of the 2nd finger	phenotype	HPO
C1862147	Medially deviated second toe	phenotype	HPO
C1864897	Cognitive delay	phenotype	HPO
C1865343	OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT OF SPINE	disease	BEFREE
C1865992	Short hallux	phenotype	HPO
C1867131	Broad hallux	phenotype	HPO
C2239176	Liver carcinoma	disease	BEFREE
C2717836	Steroid Sulfatase Deficiency Disease	disease	BEFREE
C2745900	Promyelocytic leukemia	disease	BEFREE
C2931150	Synostotic Anterior Plagiocephaly	disease	CTD_human
C2931822	Nasopharyngeal carcinoma	disease	BEFREE
C2939420	Metastatic Neoplasm	phenotype	BEFREE
C2981150	Uranostaphyloschisis	disease	BEFREE
C3203102	Idiopathic pulmonary arterial hypertension	disease	BEFREE
C3463824	MYELODYSPLASTIC SYNDROME	group	BEFREE
C3714796	Isolated somatotropin deficiency	disease	BEFREE
C3811653	Experimental Organism Basal Cell Carcinoma	phenotype	BEFREE
C3854333	Narrowing	phenotype	BEFREE
C3888088	SMITH-MCCORT DYSPLASIA 1	disease	BEFREE
C4020875	Mental and motor retardation	phenotype	HPO
C4023976	Aplasia/Hypoplasia of the middle phalanges of the toes	phenotype	HPO
C4024283	Triangular shaped middle phalanx of the 2nd finger	phenotype	HPO
C4024318	Bracket epiphysis of the middle phalanx of the 2nd finger	phenotype	HPO
C4024536	Bracket epiphysis of the middle phalanx of the 5th finger	phenotype	HPO
C4024552	Triangular shaped middle phalanx of the 5th finger	phenotype	HPO
C4049883	Obstructive Ureterocele	disease	BEFREE
C4082243	Maxillary retrognathia	phenotype	HPO
C4083076	Increased head circumference	phenotype	HPO
C4255213	Increased size of skull	phenotype	HPO
C4280538	Curvature of little finger	phenotype	HPO
C4280640	Retrusion of upper jaw bones	phenotype	HPO
C4280641	Hypotrophic maxilla	phenotype	HPO
C4280642	Deficiency of upper jaw bones	phenotype	HPO
C4280643	Decreased projection of maxilla	phenotype	HPO
C4280651	Hypotrophic malar bone	phenotype	HPO
C4280664	Big calvaria	phenotype	HPO
C4304539	20p12.3 microdeletion syndrome	disease	ORPHANET

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0004745	retinol dehydrogenase activity	ISS
GO:0005102	signaling receptor binding	TAS
GO:0005125	cytokine activity	IBA
GO:0005515	protein binding	IPI
GO:0008083	growth factor activity	IEA
GO:0019211	phosphatase activator activity	IDA
GO:0039706	co-receptor binding	IPI
GO:0046332	SMAD binding	IDA
GO:0070700	BMP receptor binding	IBA
GO:0070700	BMP receptor binding	IDA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
GO:0000122	negative regulation of transcription by RNA polymerase II	IBA
GO:0000187	activation of MAPK activity	IDA
GO:0001501	skeletal system development	TAS
GO:0001649	osteoblast differentiation	IDA
GO:0001658	branching involved in ureteric bud morphogenesis	ISS
GO:0001666	response to hypoxia	ISS
GO:0001701	in utero embryonic development	ISS
GO:0001837	epithelial to mesenchymal transition	IDA
GO:0001934	positive regulation of protein phosphorylation	IDA
GO:0001938	positive regulation of endothelial cell proliferation	IDA
GO:0002062	chondrocyte differentiation	IDA
GO:0003130	BMP signaling pathway involved in heart induction	IDA
GO:0003181	atrioventricular valve morphogenesis	ISS
GO:0003203	endocardial cushion morphogenesis	ISS
GO:0003308	negative regulation of Wnt signaling pathway involved in heart development	IDA
GO:0006029	proteoglycan metabolic process	IEA
GO:0006355	regulation of transcription, DNA-templated	IDA
GO:0006468	protein phosphorylation	IDA
GO:0006954	inflammatory response	ISS
GO:0007219	Notch signaling pathway	ISS
GO:0007267	cell-cell signaling	TAS
GO:0007507	heart development	ISS
GO:0008285	negative regulation of cell population proliferation	IDA
GO:0009617	response to bacterium	IEA
GO:0009887	animal organ morphogenesis	ISS
GO:0010628	positive regulation of gene expression	IDA
GO:0010628	positive regulation of gene expression	IGI
GO:0010629	negative regulation of gene expression	IDA
GO:0010718	positive regulation of epithelial to mesenchymal transition	IDA
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IDA
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IMP
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA
GO:0010894	negative regulation of steroid biosynthetic process	IDA
GO:0010922	positive regulation of phosphatase activity	IDA
GO:0021537	telencephalon development	IDA
GO:0021978	telencephalon regionalization	ISS
GO:0030177	positive regulation of Wnt signaling pathway	ISS
GO:0030282	bone mineralization	ISS
GO:0030335	positive regulation of cell migration	ISS
GO:0030501	positive regulation of bone mineralization	IDA
GO:0030509	BMP signaling pathway	IDA
GO:0030509	BMP signaling pathway	IEP
GO:0030509	BMP signaling pathway	IMP
GO:0030509	BMP signaling pathway	IBA
GO:0030509	BMP signaling pathway	IGI
GO:0030509	BMP signaling pathway	TAS
GO:0031648	protein destabilization	IEA
GO:0032092	positive regulation of protein binding	IDA
GO:0032348	negative regulation of aldosterone biosynthetic process	IDA
GO:0033690	positive regulation of osteoblast proliferation	ISS
GO:0035051	cardiocyte differentiation	IDA
GO:0035051	cardiocyte differentiation	IMP
GO:0035054	embryonic heart tube anterior/posterior pattern specification	ISS
GO:0035630	bone mineralization involved in bone maturation	IDA
GO:0042475	odontogenesis of dentin-containing tooth	ISS
GO:0042482	positive regulation of odontogenesis	ISS
GO:0042487	regulation of odontogenesis of dentin-containing tooth	IEA
GO:0043065	positive regulation of apoptotic process	IDA
GO:0043410	positive regulation of MAPK cascade	IDA
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	IDA
GO:0045165	cell fate commitment	ISS
GO:0045600	positive regulation of fat cell differentiation	ISS
GO:0045666	positive regulation of neuron differentiation	ISS
GO:0045669	positive regulation of osteoblast differentiation	IDA
GO:0045778	positive regulation of ossification	IDA
GO:0045786	negative regulation of cell cycle	IDA
GO:0045892	negative regulation of transcription, DNA-templated	IDA
GO:0045893	positive regulation of transcription, DNA-templated	IDA
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
GO:0045944	positive regulation of transcription by RNA polymerase II	IGI
GO:0048711	positive regulation of astrocyte differentiation	ISS
GO:0048762	mesenchymal cell differentiation	IDA
GO:0048839	inner ear development	ISS
GO:0051042	negative regulation of calcium-independent cell-cell adhesion	IDA
GO:0055007	cardiac muscle cell differentiation	IMP
GO:0055008	cardiac muscle tissue morphogenesis	ISS
GO:0055114	oxidation-reduction process	IEA
GO:0060039	pericardium development	ISS
GO:0060128	corticotropin hormone secreting cell differentiation	ISS
GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	ISS
GO:0060317	cardiac epithelial to mesenchymal transition	IDA
GO:0060389	pathway-restricted SMAD protein phosphorylation	IDA
GO:0060395	SMAD protein signal transduction	IDA
GO:0060395	SMAD protein signal transduction	IBA
GO:0060485	mesenchyme development	IMP
GO:0060804	positive regulation of Wnt signaling pathway by BMP signaling pathway	ISS
GO:0061036	positive regulation of cartilage development	IDA
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA
GO:0071407	cellular response to organic cyclic compound	IEA
GO:0071773	cellular response to BMP stimulus	IMP
GO:0071773	cellular response to BMP stimulus	IDA
GO:0072138	mesenchymal cell proliferation involved in ureteric bud development	ISS
GO:0090090	negative regulation of canonical Wnt signaling pathway	IEP
GO:1900745	positive regulation of p38MAPK cascade	IDA
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	IDA
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	IEA
GO:2000065	negative regulation of cortisol biosynthetic process	IDA
GO:2000726	negative regulation of cardiac muscle cell differentiation	IDA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IDA
GO:0005615	extracellular space	IBA
GO:0009986	cell surface	IDA
GO:0043231	intracellular membrane-bounded organelle	IDA
GO:0070724	BMP receptor complex	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1566948	Elastic fibre formation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-201451	Signaling by BMP	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2129379	Molecules associated with elastic fibres	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8878166	Transcriptional regulation by RUNX2	TAS
R-HSA-8939902	Regulation of RUNX2 expression and activity	IEA
R-HSA-9006936	Signaling by TGF-beta family members	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]	21910061
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]	21910061
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]	21910061
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]	21910061
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]	21910061
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]	21910061
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]	21910061
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of BMP2 mRNA	24810058
D015655	1-Methyl-4-phenylpyridinium	BMP2 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]	20007850
C032668	1-nitropyrene	1-nitropyrene results in increased expression of BMP2 mRNA	21540303
C548651	2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of BMP2 mRNA	19933214
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA]	17980360
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [imperatorin results in increased expression of BMP2 mRNA]	17980360
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in decreased expression of BMP2]	24531206
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of BMP2 mRNA]	26053266; 26136938;
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]	18495116
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]	18495116
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of BMP2 protein]	18495116
C408604	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]	25789987
C408604	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP2 mRNA]]	25789987; 25789987;
C408604	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]	25789987
C408604	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]	25789987
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene results in increased expression of BMP2 mRNA	20406850
C002010	4-(2-aminoethyl)benzenesulfonylfluoride	4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of BMP2 mRNA]	20660070
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of BMP2 mRNA	18648102
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]	25789987
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP2 mRNA]]	25789987; 25789987;
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]	25789987
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]	25789987
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of BMP2 mRNA]	26053266
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP2 mRNA]]	25789987; 25789987;
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP2 mRNA]]	25789987; 25789987;
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of and results in increased activity of ALPL protein]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP2 mRNA]	25789987; 25789987;
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	NOG protein inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of and results in increased activity of ALPL protein]]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP2 mRNA]]	25789987; 25789987;
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]	25789987
C000603489	(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone	SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]	25789987
D000078223	5-Methoxypsoralen	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA]	17980360
D000078223	5-Methoxypsoralen	5-Methoxypsoralen results in increased expression of BMP2 mRNA	17980360
D000078223	5-Methoxypsoralen	SB 203580 inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA]	17980360
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of BMP2 mRNA	20382639
C496492	abrine	abrine results in increased expression of BMP2 mRNA	31054353
D000079	Acetaldehyde	Acetaldehyde results in decreased expression of BMP2 protein	28017615
D000079	Acetaldehyde	N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Acetaldehyde results in decreased expression of BMP2 protein]	28017615
D000082	Acetaminophen	Acetaminophen results in decreased expression of BMP2 mRNA	26690555
D000082	Acetaminophen	Acetaminophen results in increased expression of BMP2 protein	28286204
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of BMP2 mRNA	27153756
C412373	AG 1879	AG 1879 inhibits the reaction [Resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]	17513867
C412373	AG 1879	AG 1879 inhibits the reaction [Resveratrol results in increased expression of BMP2 protein]	17513867
D000393	Air Pollutants	BMP2 gene SNP results in increased susceptibility to Air Pollutants	27082954
D000077410	Aluminum Chloride	Aluminum Chloride results in decreased expression of BMP2 mRNA	27470910
D000077410	Aluminum Chloride	ginsenoside Rb1 inhibits the reaction [Aluminum Chloride results in decreased expression of BMP2 mRNA]	27470910
D000537	Aluminum Oxide	Aluminum Oxide results in increased expression of BMP2 mRNA	19464052
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of BMP2 mRNA	16483693
D001151	Arsenic	Arsenic affects the expression of BMP2 protein	24675094
D001151	Arsenic	Arsenic results in increased expression of BMP2 protein	28903487
D000077237	Arsenic Trioxide	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in decreased expression of BMP2]	24531206
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of BMP2	24531206
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite affects the expression of BMP2 mRNA	25757056
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 mRNA	26492236
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein	26492236
D001205	Ascorbic Acid	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 mRNA]	26492236
D001205	Ascorbic Acid	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]	26492236
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 mRNA	15994055
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein	27387537
D001205	Ascorbic Acid	Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]	27387537
D001205	Ascorbic Acid	ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]	27387537
D001205	Ascorbic Acid	NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]	27387537
D000069059	Atorvastatin	Atorvastatin results in increased expression of BMP2 mRNA	17252541
D000069059	Atorvastatin	Atorvastatin results in increased secretion of BMP2 protein	16470222
C006650	aucubin	aucubin results in increased expression of BMP2 protein	29408431
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of BMP2 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of BMP2 mRNA	21839799
D001565	Benzoates	Benzoates analog results in decreased expression of BMP2 mRNA	29472718
C031463	beta-glycerophosphoric acid	[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 mRNA	26492236
C031463	beta-glycerophosphoric acid	[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein	26492236
C031463	beta-glycerophosphoric acid	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 mRNA]	26492236
C031463	beta-glycerophosphoric acid	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]	26492236
C031463	beta-glycerophosphoric acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 mRNA	15994055
C031463	beta-glycerophosphoric acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein	27387537
C031463	beta-glycerophosphoric acid	Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]	27387537
C031463	beta-glycerophosphoric acid	ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]	27387537
C031463	beta-glycerophosphoric acid	NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]	27387537
D000077610	Bexarotene	[Bexarotene co-treated with Tamoxifen] results in decreased expression of BMP2 mRNA	17630414
D001629	Bezafibrate	Bezafibrate results in increased expression of BMP2 mRNA	21499286
D001629	Bezafibrate	dorsomorphin inhibits the reaction [Bezafibrate results in increased expression of BMP2 mRNA]	21499286
D001629	Bezafibrate	GSK0660 inhibits the reaction [Bezafibrate results in increased expression of BMP2 mRNA]	21499286
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of BMP2 mRNA	27685785
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of BMP2 mRNA	30951980
C006780	bisphenol A	bisphenol A results in decreased expression of BMP2 mRNA	30075455
C006780	bisphenol A	bisphenol A results in increased expression of BMP2 mRNA	30951980
C006780	bisphenol A	bisphenol A affects the expression of BMP2 mRNA	25181051
C006780	bisphenol A	bisphenol A affects the activity of BMP2 protein	29959737
C000611646	bisphenol F	bisphenol F results in increased expression of BMP2 mRNA	30951980
C025703	bleomycetin	bleomycetin results in increased expression of BMP2 mRNA	21040473
C018475	butyraldehyde	butyraldehyde results in increased expression of BMP2 mRNA	26079696
D002104	Cadmium	Cadmium results in decreased expression of BMP2 mRNA	20570719
D002104	Cadmium	Cadmium results in increased expression of BMP2 mRNA	20570719; 21120746;
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of BMP2 mRNA	12634122
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of BMP2 mRNA	18974090
D000001	Calcimycin	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of BMP2 mRNA]	21331654
D000001	Calcimycin	[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of BMP2 mRNA	21331654
D002117	Calcitriol	Calcitriol promotes the reaction [BMP2 protein results in increased expression of SOST mRNA]	15268896
D002117	Calcitriol	Calcitriol results in increased expression of BMP2 mRNA	16002434
D002117	Calcitriol	Calcitriol results in increased expression of BMP2 protein	19092814
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of BMP2 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of BMP2 mRNA	17158861
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of BMP2 protein	17158861
D002251	Carbon Tetrachloride	gadolinium chloride promotes the reaction [Carbon Tetrachloride results in increased expression of BMP2 mRNA]	17158861
D002331	Carnitine	Carnitine inhibits the reaction [perfluorooctanoic acid results in increased expression of BMP2 protein]	29800642
C086276	cerivastatin	cerivastatin results in increased secretion of BMP2 protein	16470222
C084597	chlorcyclizine	chlorcyclizine results in increased expression of BMP2 mRNA	21058326
D002762	Cholecalciferol	BMP2 protein promotes the reaction [Cholecalciferol results in increased expression of CTNNB1 mRNA]	17170073
D002762	Cholecalciferol	Cholecalciferol results in increased expression of BMP2 mRNA	17170073
C023600	chromic oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of BMP2 mRNA	12634122
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of BMP2 mRNA	12634122
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in decreased expression of BMP2 mRNA	20705681
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of BMP2 mRNA	17602206
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin co-treated with IL1B protein] results in increased expression of BMP2 mRNA	22155307
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of BMP2 mRNA]	19924377
C018021	cobaltous chloride	cobaltous chloride affects the reaction [BMP2 protein results in increased expression of ALPL mRNA]	26054564
C018021	cobaltous chloride	cobaltous chloride affects the reaction [BMP2 protein results in increased expression of BGLAP mRNA]	26054564
C018021	cobaltous chloride	cobaltous chloride affects the reaction [BMP2 protein results in increased expression of IBSP mRNA]	26054564
C018021	cobaltous chloride	cobaltous chloride affects the reaction [BMP2 protein results in increased expression of SPP1 mRNA]	26054564
C018021	cobaltous chloride	[cobaltous chloride co-treated with BMP2 protein] results in increased expression of BGLAP protein	26054564
C018021	cobaltous chloride	cobaltous chloride results in increased expression of BMP2 mRNA	19376846
D003345	Corticosterone	Corticosterone results in increased expression of BMP2 mRNA	15755911
D003474	Curcumin	Curcumin results in decreased expression of BMP2 mRNA	27237783
D016572	Cyclosporine	Cyclosporine inhibits the reaction [Ionomycin results in increased expression of BMP2 mRNA]	17279577
D016572	Cyclosporine	Cyclosporine results in decreased expression of BMP2 mRNA	27989131
D000077209	Decitabine	[Decitabine affects the methylation of BMP2 promoter] which affects the expression of BMP2 protein	16314833; 16314833;
D003703	Demecolcine	Demecolcine results in increased expression of BMP2 mRNA	23649840
D003907	Dexamethasone	Dexamethasone inhibits the reaction [BMP2 protein results in increased expression of ACAN mRNA]	17502159
D003907	Dexamethasone	Dexamethasone inhibits the reaction [BMP2 protein results in increased expression of COL2A1 mRNA]	17502159
D003907	Dexamethasone	Dexamethasone inhibits the reaction [BMP2 protein results in increased expression of GREM1 mRNA]	15268896
D003907	Dexamethasone	Dexamethasone inhibits the reaction [BMP2 protein results in increased expression of SOST mRNA]	15268896
D003907	Dexamethasone	Dexamethasone promotes the reaction [BMP2 protein results in increased expression of SOX9 mRNA]	17502159
D003907	Dexamethasone	[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 mRNA	26492236
D003907	Dexamethasone	[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein	26492236
D003907	Dexamethasone	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 mRNA]	26492236
D003907	Dexamethasone	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]	26492236
D003907	Dexamethasone	Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]	27387537
D003907	Dexamethasone	Dexamethasone results in decreased expression of BMP2 mRNA	27387537
D003907	Dexamethasone	Dexamethasone results in decreased expression of BMP2 protein	27387537
D003907	Dexamethasone	ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]	27387537
D003907	Dexamethasone	ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 mRNA]	27387537
D003907	Dexamethasone	ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 protein]	27387537
D003907	Dexamethasone	NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]	27387537
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of BMP2 mRNA	21266533
C027118	didecyldimethylammonium	didecyldimethylammonium results in increased expression of BMP2 mRNA	23537712
D004041	Dietary Fats	[Dietary Fats co-treated with Resveratrol] results in increased expression of BMP2 mRNA	29197120
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of BMP2 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of BMP2 mRNA]	19850644
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BMP2 mRNA	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of BMP2 mRNA	17602206
C516138	dorsomorphin	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
C516138	dorsomorphin	dorsomorphin inhibits the reaction [Bezafibrate results in increased expression of BMP2 mRNA]	21499286
D004317	Doxorubicin	Doxorubicin affects the expression of BMP2 mRNA	29803840
D004726	Endosulfan	Endosulfan results in increased expression of BMP2 mRNA	29391264
C118739	entinostat	entinostat results in increased expression of BMP2 mRNA	26272509
C118739	entinostat	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
D004837	Epinephrine	Epinephrine results in decreased expression of BMP2 mRNA	31520687
D004837	Epinephrine	Epinephrine results in decreased expression of BMP2 protein	31520687
D004958	Estradiol	4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of BMP2 mRNA]	20660070
D004958	Estradiol	BMP2 protein results in increased abundance of Estradiol	23313114
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of BMP2 mRNA	20660070
D004958	Estradiol	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of BMP2 mRNA]	20660070
D004958	Estradiol	[Letrozole results in decreased abundance of Estradiol] which results in decreased expression of BMP2 mRNA	19620711
D004958	Estradiol	BMP2 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]	22067323
D004958	Estradiol	[BMP2 protein results in increased expression of CYP19A1 mRNA] promotes the reaction [FSHB protein results in increased abundance of Estradiol]	22067323
D004958	Estradiol	CARTPT protein inhibits the reaction [BMP2 protein results in increased abundance of Estradiol]	23313114
D000431	Ethanol	Ethanol affects the expression of BMP2 mRNA	30319688
D000431	Ethanol	Ethanol affects the splicing of BMP2 mRNA	30319688
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of BMP2 mRNA	15834898; 17557909;
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of BMP2 mRNA	23649840
C004808	farnesyl pyrophosphate	farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]	18310456
D017313	Fenretinide	Fenretinide results in increased expression of BMP2 mRNA	15958647
D017313	Fenretinide	Fenretinide results in increased secretion of BMP2 protein	15958647
C082360	fipronil	fipronil results in increased expression of BMP2 mRNA	23962444
D005419	Flavonoids	Flavonoids results in decreased expression of BMP2 mRNA	18035473
D005459	Fluorides	Fluorides inhibits the reaction [potassium phosphate results in increased expression of BMP2 mRNA]	24561004
D005557	Formaldehyde	Formaldehyde results in increased expression of BMP2 mRNA	23649840
C069837	fullerene C60	fullerene C60 results in decreased expression of BMP2 mRNA	19167457
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]	17513867
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Resveratrol results in increased expression of BMP2 mRNA]	17513867
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [naringin results in increased secretion of BMP2 protein]	23596885
C005023	fulvic acid	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of BMP2 mRNA]	21331654
C039281	furan	furan results in decreased expression of BMP2 mRNA	26194646
C038958	gadolinium chloride	gadolinium chloride promotes the reaction [Carbon Tetrachloride results in increased expression of BMP2 mRNA]	17158861
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid affects the expression of BMP2 mRNA	24098073
D019833	Genistein	Genistein results in increased expression of BMP2 mRNA	22228119
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in decreased expression of BMP2 mRNA	21782745
C002963	geranylgeranyl pyrophosphate	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]	18310456
C442759	ginsenoside Rb1	ginsenoside Rb1 inhibits the reaction [Aluminum Chloride results in decreased expression of BMP2 mRNA]	27470910
C442759	ginsenoside Rb1	ginsenoside Rb1 results in increased expression of BMP2 mRNA	27470910
C097367	ginsenoside Rg3	ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]	27387537
C097367	ginsenoside Rg3	ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 mRNA]	27387537
C097367	ginsenoside Rg3	ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 protein]	27387537
C097367	ginsenoside Rg3	NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]	27387537
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of BMP2 mRNA]	17109745
D005947	Glucose	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of BMP2 mRNA]	19924377
D005947	Glucose	Glucose results in decreased expression of BMP2 mRNA	19924377
D005947	Glucose	tin mesoporphyrin promotes the reaction [Glucose results in decreased expression of BMP2 mRNA]	19924377
C010974	glyphosate	glyphosate results in decreased expression of BMP2 mRNA	27486271
C529769	GSK0660	GSK0660 inhibits the reaction [Bezafibrate results in increased expression of BMP2 mRNA]	21499286
C577920	GSK126	BMP2 protein inhibits the reaction [GSK126 results in increased expression of ALPL mRNA]	26424790
D006569	Hesperidin	Hesperidin results in increased expression of BMP2 mRNA	21820093
C056599	icariin	icariin results in increased expression of BMP2 mRNA	15724410; 17355822;
C056599	icariin	icariin results in increased expression of BMP2 mRNA	19747809
C056599	icariin	NOG protein inhibits the reaction [icariin results in increased expression of BMP2 mRNA]	19747809
C056599	icariin	icariin results in increased expression of BMP2 mRNA	16543677; 20019778;
C031534	imperatorin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [imperatorin results in increased expression of BMP2 mRNA]	17980360
C031534	imperatorin	imperatorin results in increased expression of BMP2 mRNA	17980360
C031534	imperatorin	SB 203580 inhibits the reaction [imperatorin results in increased expression of BMP2 mRNA]	17980360
D015759	Ionomycin	Cyclosporine inhibits the reaction [Ionomycin results in increased expression of BMP2 mRNA]	17279577
D015759	Ionomycin	Ionomycin results in increased expression of BMP2 mRNA	17279577
C544151	jinfukang	jinfukang results in increased expression of BMP2 mRNA	27392435
C006552	kaempferol	kaempferol results in increased expression of BMP2 mRNA	23989061
C006552	kaempferol	kaempferol results in increased expression of BMP2 protein	23989061
D019344	Lactic Acid	Lactic Acid results in decreased expression of BMP2 mRNA	30851411
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of BMP2 mRNA	12634122
C008261	lead acetate	BMP2 promotes the reaction [lead acetate results in increased expression of ACAN mRNA]	17805416
C008261	lead acetate	BMP2 promotes the reaction [lead acetate results in increased expression of COL2A1 mRNA]	17805416
C008261	lead acetate	BMP2 promotes the reaction [lead acetate results in increased expression of SOX9 mRNA]	17805416
C008261	lead acetate	lead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD1 protein]	17805416
C008261	lead acetate	lead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD5 protein]	17805416
C008261	lead acetate	lead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD9 protein]	17805416
C008261	lead acetate	lead acetate promotes the reaction [BMP2 results in increased expression of ACAN mRNA]	17805416
C008261	lead acetate	lead acetate promotes the reaction [BMP2 results in increased expression of SOX9 mRNA]	17805416
C008261	lead acetate	lead acetate results in increased activity of BMP2 protein	17805416
C008261	lead acetate	lead acetate results in increased expression of BMP2 mRNA	21829687
C008261	lead acetate	lead acetate results in decreased expression of BMP2 mRNA	22641619
D000077289	Letrozole	[Letrozole results in decreased abundance of Estradiol] which results in decreased expression of BMP2 mRNA	19620711
C482199	lipopolysaccharide, E coli O55-B5	lipopolysaccharide, E coli O55-B5 inhibits the reaction [BMP2 protein results in increased expression of BGLAP protein]	26961602
C482199	lipopolysaccharide, E coli O55-B5	lipopolysaccharide, E coli O55-B5 inhibits the reaction [BMP2 protein results in increased expression of RUNX2 protein]	26961602
C482199	lipopolysaccharide, E coli O55-B5	lipopolysaccharide, E coli O55-B5 inhibits the reaction [BMP2 protein results in increased expression of SPP1 protein]	26961602
C482199	lipopolysaccharide, E coli O55-B5	MIR23B mRNA inhibits the reaction [lipopolysaccharide, E coli O55-B5 inhibits the reaction [BMP2 protein results in increased expression of BGLAP protein]]	26961602
C482199	lipopolysaccharide, E coli O55-B5	MIR23B mRNA inhibits the reaction [lipopolysaccharide, E coli O55-B5 inhibits the reaction [BMP2 protein results in increased expression of RUNX2 protein]]	26961602
C482199	lipopolysaccharide, E coli O55-B5	MIR23B mRNA inhibits the reaction [lipopolysaccharide, E coli O55-B5 inhibits the reaction [BMP2 protein results in increased expression of SPP1 protein]]	26961602
D008070	Lipopolysaccharides	Triclosan promotes the reaction [Lipopolysaccharides results in increased expression of BMP2 mRNA]	20507366
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of BMP2 mRNA	16415329
D008070	Lipopolysaccharides	Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of BMP2 mRNA]	16415329
D019808	Losartan	Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]	27412937
D019808	Losartan	Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein]	27412937
D008344	Maneb	[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA	23017109
D008727	Methotrexate	Methotrexate results in increased expression of BMP2 mRNA	20008919; 21678067;
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in decreased expression of BMP2 mRNA	21782745
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of BMP2 mRNA	23179753; 28001369;
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of BMP2 mRNA	26272509
C020771	methylmercury hydroxide	methylmercury hydroxide results in increased expression of BMP2 mRNA	20493249
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of BMP2 mRNA	23649840
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BMP2 mRNA]	10814523
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BMP2 mRNA]	18628692
C012258	mevastatin	mevastatin results in increased expression of BMP2 mRNA	10814523
C012258	mevastatin	mevastatin results in increased expression of BMP2 protein	10814523
D016685	Mitomycin	Mitomycin results in decreased expression of BMP2 mRNA	25270620
C091888	monoisoamyl-2,3-dimercaptosuccinate	monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of BMP2 mRNA	19615344
C500085	muraglitazar	muraglitazar results in decreased expression of BMP2 mRNA	21515302
C531525	N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide	ALDH2 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of BMP2 protein]	28017615
C531525	N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide	N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Acetaldehyde results in decreased expression of BMP2 protein]	28017615
C531525	N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide	N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of and results in increased secretion of BMP2 protein	28017615
C531525	N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide	N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of BMP2 mRNA	28017615
C531525	N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide	N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of BMP2 protein	28017615
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of BMP2 mRNA]	20660070
C028473	N-acetyl-4-benzoquinoneimine	N-acetyl-4-benzoquinoneimine results in increased expression of BMP2 mRNA	28286204
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of BMP2 mRNA	15585362
C066406	naringenin-6-C-glucoside	naringenin-6-C-glucoside results in increased expression of BMP2 mRNA	21864313
C005274	naringin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]	18495116
C005274	naringin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]	18495116
C005274	naringin	FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]	18495116
C005274	naringin	FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]	18495116
C005274	naringin	JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]	18495116
C005274	naringin	JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]	18495116
C005274	naringin	naringin promotes the reaction [FOS protein binds to BMP2 promoter]	18495116
C005274	naringin	naringin promotes the reaction [JUN protein binds to BMP2 promoter]	18495116
C005274	naringin	naringin results in increased expression of BMP2 mRNA	18495116
C005274	naringin	naringin results in increased expression of BMP2 protein	18495116
C005274	naringin	Fulvestrant inhibits the reaction [naringin results in increased secretion of BMP2 protein]	23596885
C005274	naringin	naringin results in decreased expression of BMP2 mRNA	21820093
C005274	naringin	naringin results in increased secretion of BMP2 protein	23596885
C005274	naringin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of BMP2 protein]	18495116
C028007	nickel monoxide	nickel monoxide results in decreased expression of BMP2 mRNA	19167457
D018817	N-Methyl-3,4-methylenedioxyamphetamine	N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BMP2 mRNA	26251327
C434926	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 mRNA]	26492236
C434926	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [[Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]	26492236
D015282	Octreotide	Octreotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA]	23137853
D000077150	Oxaliplatin	[Oxaliplatin co-treated with Topotecan] results in increased expression of BMP2 mRNA	25729387
D000077150	Oxaliplatin	Oxaliplatin results in increased expression of BMP2 mRNA	25729387
D010100	Oxygen	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of BMP2 mRNA	30529165
D010100	Oxygen	Oxygen deficiency results in increased expression of BMP2 mRNA	26476374
D010100	Oxygen	Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of BMP2 mRNA]	26476374
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in decreased expression of BMP2 mRNA	20705681
D000077767	Panobinostat	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
D000077767	Panobinostat	Panobinostat results in increased expression of BMP2 mRNA	26272509
D010269	Paraquat	[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA	23017109
D052638	Particulate Matter	Particulate Matter results in increased expression of BMP2 mRNA	24769257
C517782	pasireotide	pasireotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA]	23137853
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of BMP2 mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of BMP2 mRNA	30738844
C023036	perfluorooctanoic acid	BMP2 protein results in decreased susceptibility to perfluorooctanoic acid	29800642
C023036	perfluorooctanoic acid	Carnitine inhibits the reaction [perfluorooctanoic acid results in increased expression of BMP2 protein]	29800642
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of BMP2 mRNA	23941634
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of BMP2 protein	29800642
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BMP2 mRNA	24535843
D010634	Phenobarbital	Phenobarbital affects the expression of BMP2 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of BMP2 mRNA	12832660
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of BMP2 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BMP2 mRNA	19710929
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in decreased expression of BMP2 mRNA	27989595
C013216	potassium phosphate	Fluorides inhibits the reaction [potassium phosphate results in increased expression of BMP2 mRNA]	24561004
C013216	potassium phosphate	potassium phosphate results in increased expression of BMP2 mRNA	24561004
D011374	Progesterone	4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of BMP2 mRNA]	20660070
D011374	Progesterone	BMP2 protein results in decreased abundance of Progesterone	20639315; 23313114;
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of BMP2 mRNA	20660070
D011374	Progesterone	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of BMP2 mRNA]	20660070
D011374	Progesterone	NOG protein inhibits the reaction [BMP2 protein results in decreased abundance of Progesterone]	20639315
D011374	Progesterone	Progesterone results in decreased expression of BMP2 mRNA	20660070
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of BMP2 mRNA]	17556502
D011374	Progesterone	PGR protein affects the reaction [Progesterone results in decreased expression of BMP2 mRNA]	17556502
D011374	Progesterone	Progesterone results in decreased expression of BMP2 mRNA	17556502
D011374	Progesterone	[BMP2 protein results in decreased expression of STAR mRNA] inhibits the reaction [FSHB protein results in increased abundance of Progesterone]	22067323
D011374	Progesterone	IGF1 protein inhibits the reaction [BMP2 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]	22067323
D011441	Propylthiouracil	Propylthiouracil affects the expression of BMP2 mRNA	24780913
D011794	Quercetin	Quercetin results in increased expression of BMP2 mRNA	16996034
D011794	Quercetin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of BMP2 mRNA]	26053266; 26136938;
D011794	Quercetin	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of BMP2 mRNA]	26053266
D011794	Quercetin	Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of BMP2 mRNA]	26476374
D011794	Quercetin	Quercetin results in increased expression of BMP2 mRNA	26053266; 26136938;
D011794	Quercetin	SB 203580 inhibits the reaction [Quercetin results in increased expression of BMP2 mRNA]	26136938
C502851	quinocetone	quinocetone results in increased expression of BMP2 mRNA	27046791
D011899	Ranitidine	Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of BMP2 mRNA]	16415329
C052785	rebamipide	rebamipide results in increased expression of BMP2 mRNA	15104358
D000077185	Resveratrol	AG 1879 inhibits the reaction [Resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]	17513867
D000077185	Resveratrol	AG 1879 inhibits the reaction [Resveratrol results in increased expression of BMP2 protein]	17513867
D000077185	Resveratrol	FOXA1 protein promotes the reaction [Resveratrol results in increased expression of BMP2 protein]	17513867
D000077185	Resveratrol	Fulvestrant inhibits the reaction [Resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]	17513867
D000077185	Resveratrol	Fulvestrant inhibits the reaction [Resveratrol results in increased expression of BMP2 mRNA]	17513867
D000077185	Resveratrol	Resveratrol inhibits the reaction [TNF protein results in increased expression of BMP2 mRNA]	16973825
D000077185	Resveratrol	Resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]	17513867
D000077185	Resveratrol	Resveratrol results in increased expression of BMP2 mRNA	17513867
D000077185	Resveratrol	Resveratrol results in increased expression of BMP2 protein	17513867
D000077185	Resveratrol	Tamoxifen inhibits the reaction [Resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]	17513867
D000077185	Resveratrol	[Dietary Fats co-treated with Resveratrol] results in increased expression of BMP2 mRNA	29197120
D000077185	Resveratrol	Resveratrol results in decreased expression of BMP2 mRNA	25338179
C009172	rhodioloside	rhodioloside results in increased expression of BMP2 mRNA	24055767
D000077154	Rosiglitazone	Rosiglitazone results in decreased expression of BMP2 mRNA	21515302
C541923	sandostatinLAR	sandostatinLAR results in increased expression of BMP2 mRNA	17210224
C093642	SB 203580	SB 203580 results in decreased expression of BMP2 mRNA	20660070
C093642	SB 203580	SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of ALPL mRNA]]	25789987
C093642	SB 203580	SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP2 mRNA]]	25789987; 25789987;
C093642	SB 203580	SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP6 mRNA]]	25789987
C093642	SB 203580	SB 203580 inhibits the reaction [(4-(7-chloroquinolin-4-yl)piperazino)(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone promotes the reaction [BMP2 protein results in increased expression of BMP7 mRNA]]	25789987
C093642	SB 203580	SB 203580 inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA]	17980360
C093642	SB 203580	SB 203580 inhibits the reaction [imperatorin results in increased expression of BMP2 mRNA]	17980360
C093642	SB 203580	SB 203580 inhibits the reaction [Quercetin results in increased expression of BMP2 mRNA]	26136938
C078903	seocalcitol	seocalcitol results in increased expression of BMP2 mRNA	12040012
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of BMP2 mRNA	21540303
D012834	Silver	Silver results in increased expression of BMP2 mRNA	27131904
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BMP2 mRNA]	10814523
D019821	Simvastatin	Simvastatin results in increased expression of BMP2	20381859
D019821	Simvastatin	Simvastatin results in increased expression of BMP2 mRNA	10814523; 17252541;
D019821	Simvastatin	Simvastatin results in increased secretion of BMP2 protein	16470222
D019821	Simvastatin	farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]	18310456
D019821	Simvastatin	geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]	18310456
D019821	Simvastatin	Simvastatin inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]	18310456
D019821	Simvastatin	Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD1 protein]]	18310456
D019821	Simvastatin	Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD5 protein]]	18310456
D019821	Simvastatin	Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD9 protein]]	18310456
D019821	Simvastatin	Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]	18310456
D019821	Simvastatin	Simvastatin results in increased expression of BMP2	12914771
D019821	Simvastatin	Simvastatin results in increased expression of BMP2 mRNA	11162604; 20417880;
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BMP2 mRNA]	18628692
D019821	Simvastatin	Simvastatin results in increased expression of BMP2 mRNA	18628692; 19912653; 20024970; 20687301;
D019821	Simvastatin	Simvastatin results in increased expression of BMP2 protein	19292885
D019821	Simvastatin	Simvastatin results in increased expression of BMP2	17721043
C017947	sodium arsenite	sodium arsenite affects the expression of BMP2 mRNA	19615344
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of BMP2 mRNA	12634122
C017947	sodium arsenite	sodium arsenite results in increased expression of BMP2 mRNA	10910055
D012999	Soman	Soman results in increased expression of BMP2 mRNA	19281266
D053260	Soot	Soot results in decreased expression of BMP2 mRNA	26551751
D000077210	Sunitinib	Sunitinib results in increased expression of BMP2 mRNA	31533062
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]	17513867
D013629	Tamoxifen	[Bexarotene co-treated with Tamoxifen] results in decreased expression of BMP2 mRNA	17630414
C021751	tanshinone	BMP2 protein promotes the reaction [tanshinone results in increased phosphorylation of JUN protein]	31306638
C021751	tanshinone	MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of BMP2 protein]	31306638
C021751	tanshinone	tanshinone results in increased expression of BMP2 protein	31306638
D013739	Testosterone	Testosterone results in decreased expression of BMP2 mRNA	22138414
D013749	Tetrachlorodibenzodioxin	[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BMP2 mRNA	14761676
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BMP2 mRNA	24035824
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BMP2 mRNA	19933214
D013749	Tetrachlorodibenzodioxin	[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of BMP2 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BMP2 mRNA	11752688
D013755	Tetradecanoylphorbol Acetate	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of BMP2 mRNA]	21331654
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of BMP2 mRNA	21331654
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of BMP2 mRNA	10910055
C055421	tin mesoporphyrin	tin mesoporphyrin promotes the reaction [Glucose results in decreased expression of BMP2 mRNA]	19924377
C055421	tin mesoporphyrin	tin mesoporphyrin results in decreased expression of BMP2 mRNA	19924377
C009495	titanium dioxide	[Vitallium analog binds to titanium dioxide] which results in decreased expression of BMP2 mRNA	23825117
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased methylation of BMP2 gene	26756918
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of BMP2 mRNA	27237783
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of BMP2 mRNA	29545142
D019772	Topotecan	[Oxaliplatin co-treated with Topotecan] results in increased expression of BMP2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of BMP2 mRNA	25729387
D014118	Toxins, Biological	Toxins, Biological affects the expression of BMP2 mRNA	19682533
D014212	Tretinoin	Tretinoin promotes the reaction [BMP2 protein results in increased expression of SOST mRNA]	15268896
D014212	Tretinoin	Tretinoin results in increased expression of BMP2 mRNA	17196394; 21934132;
D014212	Tretinoin	Tretinoin results in increased expression of BMP2 mRNA	16604517
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
C012589	trichostatin A	trichostatin A results in increased expression of BMP2 mRNA	26272509
C012589	trichostatin A	trichostatin A results in increased expression of BMP2 mRNA	23562654
C012589	trichostatin A	trichostatin A results in increased expression of BMP2 protein	23562654
D014260	Triclosan	Triclosan promotes the reaction [Lipopolysaccharides results in increased expression of BMP2 mRNA]	20507366
D014260	Triclosan	Triclosan results in decreased expression of BMP2 mRNA	30510588
D014284	Triiodothyronine	[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BMP2 mRNA	14761676
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of BMP2 mRNA	19042947
D000077288	Troglitazone	Troglitazone results in decreased expression of BMP2 mRNA	21515302
D000077288	Troglitazone	BMP2 protein promotes the reaction [Troglitazone results in increased expression of LPL mRNA]	19122273
D000077288	Troglitazone	[Troglitazone co-treated with BMP2 protein] results in increased expression of CFD mRNA	19122273
D000077288	Troglitazone	Troglitazone inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]	19122273
D000077288	Troglitazone	Troglitazone inhibits the reaction [BMP2 protein results in increased expression of COL1A2 mRNA]	19122273
D000077288	Troglitazone	Troglitazone inhibits the reaction [BMP2 protein results in increased expression of RUNX2 mRNA]	19122273
D000077288	Troglitazone	Troglitazone inhibits the reaction [BMP2 protein results in increased expression of VDR mRNA]	19122273
D000077288	Troglitazone	Troglitazone promotes the reaction [BMP2 protein affects the expression of PPARG mRNA]	19122273
D000077288	Troglitazone	Troglitazone promotes the reaction [BMP2 protein results in decreased expression of PTH1R mRNA]	19122273
D000077288	Troglitazone	Troglitazone promotes the reaction [BMP2 protein results in decreased expression of SPP1 mRNA]	19122273
D000077288	Troglitazone	Troglitazone results in decreased susceptibility to BMP2 protein	19122273
D014415	Tunicamycin	Tunicamycin results in increased expression of BMP2 mRNA	17127020
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of BMP2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of BMP2 mRNA	23179753; 29154799;
D014635	Valproic Acid	Valproic Acid results in decreased methylation of BMP2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of BMP2 mRNA	26272509
D014635	Valproic Acid	Valproic Acid results in increased expression of BMP2 mRNA	27237783
D014635	Valproic Acid	Valproic Acid results in increased expression of BMP2 mRNA	23562654
D014635	Valproic Acid	Valproic Acid results in increased expression of BMP2 protein	23562654
C066075	vanadium pentoxide	vanadium pentoxide affects the expression of BMP2 mRNA	17459161
D001335	Vehicle Emissions	BMP2 gene SNP results in increased susceptibility to Vehicle Emissions	27082954
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of BMP2 gene	25560391
D014750	Vincristine	Vincristine results in increased expression of BMP2 mRNA	23649840
D014800	Vitallium	[Vitallium analog binds to titanium dioxide] which results in decreased expression of BMP2 mRNA	23825117
D010837	Vitamin K 1	Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]	27412937
D010837	Vitamin K 1	Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein]	27412937
D010837	Vitamin K 1	[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA	27412937
D010837	Vitamin K 1	[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein	27412937
D024482	Vitamin K 2	Vitamin K 2 affects the reaction [PTH protein results in increased expression of BMP2 protein]	30639440
D000077337	Vorinostat	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BMP2 mRNA	27188386
D000077337	Vorinostat	Vorinostat results in increased expression of BMP2 mRNA	26272509
D014859	Warfarin	Warfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]	21910061
D014859	Warfarin	Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]	21910061
D014859	Warfarin	Warfarin inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]	21910061
D014859	Warfarin	Warfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]	21910061
D014859	Warfarin	Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]	21910061
D014859	Warfarin	Warfarin inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]	21910061
D014859	Warfarin	Warfarin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]	21910061
D014859	Warfarin	Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]	27412937
D014859	Warfarin	Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein]	27412937
D014859	Warfarin	[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA	27412937
D014859	Warfarin	[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein	27412937
D014859	Warfarin	SNAI2 protein promotes the reaction [[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of BMP2 mRNA]	29358327
D014859	Warfarin	[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of BMP2 mRNA	29358327
D014859	Warfarin	[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of BMP2 protein	29358327
C108830	Y 27632	Y 27632 results in increased expression of BMP2 mRNA	17279577
D000077211	Zoledronic Acid	Zoledronic Acid results in increased expression of BMP2 mRNA	14751568; 24714768;

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0891	Chondrogenesis
KW-0165	Cleavage on pair of basic residues
KW-0202	Cytokine
KW-0217	Developmental protein
KW-0221	Differentiation
KW-0225	Disease mutation
KW-1015	Disulfide bond
KW-0242	Dwarfism
KW-0325	Glycoprotein
KW-0339	Growth factor
KW-0892	Osteogenesis
KW-0582	Pharmaceutical
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal

Interpro

InterPro ID	InterPro Term
IPR029034	Cystine-knot_cytokine
IPR001839	TGF-b_C
IPR001111	TGF-b_propeptide
IPR015615	TGF-beta-rel
IPR017948	TGFb_CS

PROSITE

PROSITE ID	PROSITE Term
PS00250	TGF_BETA_1
PS51362	TGF_BETA_2

Pfam

Pfam ID	Pfam Term
PF00019	TGF_beta
PF00688	TGFb_propeptide

Gene: BMP2

Basic information

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction