| Tag | Content |
|---|---|
| Uniprot ID | P12644; Q9UM80; |
| Entrez ID | 652 |
| Genbank protein ID | AAH20546.1; BAA06410.1; AAC72278.1; AAA51835.1; |
| Genbank nucleotide ID | NM_001347916.1; NM_130851.3; NM_130850.4; NM_001202.5; NM_001347914.1; |
| Ensembl protein ID | ENSP00000454134; ENSP00000394165; ENSP00000245451; ENSP00000453485; |
| Ensembl nucleotide ID | ENSG00000125378 |
| Gene name | Bone morphogenetic protein 4 |
| Gene symbol | BMP4 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | CPO,CL/P |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 18771417; 19839778; 23227324; 22182590; 23237431; 19249007; 26424979; 22514733; 19914800; |
| Functional description | Induces cartilage and bone formation. Also acts in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). |
| Sequence | MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 60 LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF 120 HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI 180 YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH 240 LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR 300 ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 360 VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR 408 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.