CleftGeneDB-Search

Gene: CDH1

Basic information

Tag	Content
Uniprot ID	P12830; A8K1U7; Q13799; Q14216; Q15855; Q16194; Q4PJ14; Q9UII8;
Entrez ID	999
Genbank protein ID	BAA08537.1; CAA84586.1; CAA78353.1; CAA36522.1; EAW83244.1; AAA61259.1; BAF82701.1; EAW83243.1; BAA88956.1; AAA21764.1; AAY68225.1; AAD14108.1; BAG35448.1; CAA79356.1; CAA31279.1;
Genbank nucleotide ID	NM_001317185.1; NM_001317184.1; NM_004360.4; NM_001317186.1;
Ensembl protein ID	ENSP00000261769; ENSP00000414946;
Ensembl nucleotide ID	ENSG00000039068
Gene name	Cadherin-1
Gene symbol	CDH1
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type	CPO,CL/P
Developmental stage
Data sources	Manually collected
Reference	26123647; 20880515; 28376813; 28151848; 24838934;
Functional description	Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
Sequence	MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC 60 TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG 120 HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS 180 NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN 240 AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI 300 AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT 360 AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG 420 GQFVVTTNPV NNDGILKTAK GLDFEAKQQY ILHVAVTNVV PFEVSLTTST ATVTVDVLDV 480 NEAPIFVPPE KRVEVSEDFG VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG 540 AISTRAELDR EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI 600 FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI ILKPKMALEV 660 GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP VEAGLQIPAI LGILGGILAL 720 LILILLLLLF LRRRAVVKEP LLPPEDDTRD NVYYYDEEGG GEEDQDFDLS QLHRGLDARP 780 EVTRNDVAPT LMSVPRYLPR PANPDEIGNF IDENLKAADT DPTAPPYDSL LVFDYEGSGS 840 EAASLSSLNS SESDKDQDYD YLNEWGNRFK KLADMYGGGE DD 882

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1O6S
2O72
2OMT
2OMU
2OMV
2OMX
2OMY
2OMZ
3FF7
3FF8
3L6X
3L6Y
4ZT1
4ZTE
6CXY
6OLE
6OLF
6OLG
6VEL
1O6S
2OMU
2OMV
2OMY
2OMZ
3L6X

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
CDH1	c.760G>A; p.Asp254Asn	Next-generation sequencing (NGS; exome or targeted gene sequencing) and Sanger sequencing (SS)	26123647
CDH1	rs1801552	TaqMan genotyping	24838934
CDH1	rs16260	PCR-RFLP	20880515
CDH1	rs1801552C>T	Genotyping	28151848
CDH1	c.760G>A; p.Asp254Asn	exome or targeted gene sequencing and Sanger sequencing	26123647
CDH1	c.468G>C; pTrp156Cys (heterozygous)	WES and Sanger sequencing	3168429
CDH1	g.68844164C>T; p.Thr251Met	WES and Sanger sequencing	29805042
CDH1	g.68844172G>A; p.Asp254Asn	WES and Sanger sequencing	29805042
CDH1	g.68844180T>A; p.Asn256Lys	WES and Sanger sequencing	29805042
CDH1	g.68849586G>A; p.Glu497Lys	WES and Sanger sequencing	29805042
CDH1	g.68855958A>T; p.Asn589Ile	WES and Sanger sequencing	29805042
CDH1	g.68863687_68863688del; p.Asn809Ilefs*3	WES and Sanger sequencing	29805042

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
RCV000230267	p.Met1Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737418G>A	ClinVar
RCV000570172	p.Met1Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68737418G>A	ClinVar
RCV000639275	p.Met1Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737417T>G	ClinVar
RCV000566678	p.Met1Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68737417T>C	ClinVar
RCV000639234	p.Met1Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737417T>C	ClinVar
RCV000639240	p.Met1Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737416A>G	ClinVar
RCV000759733	p.Met1Ile	missense variant	-	NC_000016.10:g.68737418G>A	ClinVar
RCV000163100	p.Gly2Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68737419G>A	ClinVar
RCV000484462	p.Gly2Ser	missense variant	-	NC_000016.10:g.68737419G>A	ClinVar
rs786201212	p.Gly2Ser	missense variant	-	NC_000016.10:g.68737419G>A	gnomAD
RCV000458853	p.Gly2Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737419G>A	ClinVar
RCV000777434	p.Gly2Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68737420G>A	ClinVar
RCV000231609	p.Gly2Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737420G>T	ClinVar
rs878854692	p.Gly2Val	missense variant	-	NC_000016.10:g.68737420G>T	gnomAD
rs587782484	p.Pro3His	missense variant	-	NC_000016.10:g.68737423C>A	ExAC,TOPMed,gnomAD
RCV000485012	p.Pro3Ser	missense variant	-	NC_000016.10:g.68737422C>T	ClinVar
RCV000212345	p.Pro3Arg	missense variant	-	NC_000016.10:g.68737423C>G	ClinVar
RCV000773783	p.Pro3Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68737422C>A	ClinVar
rs1064793079	p.Pro3Ser	missense variant	-	NC_000016.10:g.68737422C>T	-
RCV000817256	p.Pro3Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737422C>T	ClinVar
rs587782484	p.Pro3Arg	missense variant	-	NC_000016.10:g.68737423C>G	ExAC,TOPMed,gnomAD
RCV000662736	p.Trp4Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737427G>A	ClinVar
rs1555509636	p.Trp4Ter	stop gained	-	NC_000016.10:g.68737427G>A	-
RCV000559657	p.Ser5Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737428A>G	ClinVar
rs786201287	p.Ser5Arg	missense variant	-	NC_000016.10:g.68737430C>G	TOPMed,gnomAD
rs1555509637	p.Ser5Gly	missense variant	-	NC_000016.10:g.68737428A>G	-
rs746464544	p.Arg6His	missense variant	-	NC_000016.10:g.68737432G>A	ExAC,gnomAD
rs746464544	p.Arg6Leu	missense variant	-	NC_000016.10:g.68737432G>T	ExAC,gnomAD
rs1303550652	p.Ser7Gly	missense variant	-	NC_000016.10:g.68737434A>G	gnomAD
rs1310934198	p.Ser7Thr	missense variant	-	NC_000016.10:g.68737435G>C	gnomAD
rs587778169	p.LeuSer8LeuPro	missense variant	-	NC_000016.10:g.68737439_68737440delinsGC	-
rs1234138761	p.Leu8Val	missense variant	-	NC_000016.10:g.68737437C>G	gnomAD
RCV000639268	p.Ser9Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737440T>G	ClinVar
RCV000802433	p.Ser9Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737441C>T	ClinVar
rs1555509646	p.Ser9Leu	missense variant	-	NC_000016.10:g.68737441C>T	-
RCV000561107	p.Ser9Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68737441C>T	ClinVar
RCV000120496	p.Ser9Pro	missense variant	-	NC_000016.10:g.68737439_68737440delinsGC	ClinVar
rs1555509645	p.Ser9Ala	missense variant	-	NC_000016.10:g.68737440T>G	-
RCV000639226	p.Ala10Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737444C>T	ClinVar
RCV000732057	p.Ala10Glu	missense variant	-	NC_000016.10:g.68737444C>A	ClinVar
rs1375360857	p.Ala10Glu	missense variant	-	NC_000016.10:g.68737444C>A	TOPMed
rs1053572488	p.Ala10Thr	missense variant	-	NC_000016.10:g.68737443G>A	TOPMed,gnomAD
RCV000709391	p.Ala10Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737444C>A	ClinVar
rs1375360857	p.Ala10Val	missense variant	-	NC_000016.10:g.68737444C>T	TOPMed
RCV000709392	p.Leu11Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737447T>G	ClinVar
rs1393903966	p.Leu11Arg	missense variant	-	NC_000016.10:g.68737447T>G	TOPMed
rs1191249318	p.Leu12Pro	missense variant	-	NC_000016.10:g.68737450T>C	gnomAD
rs1192852993	p.Leu14Met	missense variant	-	NC_000016.10:g.68737455C>A	gnomAD
rs370614162	p.Leu15Gln	missense variant	-	NC_000016.10:g.68737459T>A	ESP,TOPMed,gnomAD
RCV000772459	p.Gln16Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68737462A>T	ClinVar
RCV000475151	p.Gln16His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68737463G>T	ClinVar
rs770244203	p.Gln16Ter	stop gained	-	NC_000016.10:g.68737461C>T	ExAC,gnomAD
rs775705607	p.Gln16Arg	missense variant	-	NC_000016.10:g.68737462A>G	ExAC,gnomAD
rs749591910	p.Gln16His	missense variant	-	NC_000016.10:g.68737463G>T	ExAC,gnomAD
rs775705607	p.Gln16Pro	missense variant	-	NC_000016.10:g.68737462A>C	ExAC,gnomAD
rs770244203	p.Gln16Lys	missense variant	-	NC_000016.10:g.68737461C>A	ExAC,gnomAD
rs780470521	p.Val17Phe	missense variant	-	NC_000016.10:g.68738297G>T	ExAC,gnomAD
RCV000456580	p.Val17Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738297G>C	ClinVar
rs780470521	p.Val17Leu	missense variant	-	NC_000016.10:g.68738297G>C	ExAC,gnomAD
RCV000465064	p.Ser19Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738303T>G	ClinVar
RCV000574640	p.Ser19Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738304C>G	ClinVar
rs1221633501	p.Ser19Phe	missense variant	-	NC_000016.10:g.68738304C>T	TOPMed,gnomAD
rs1042391377	p.Ser19Ala	missense variant	-	NC_000016.10:g.68738303T>G	gnomAD
rs1221633501	p.Ser19Tyr	missense variant	-	NC_000016.10:g.68738304C>A	TOPMed,gnomAD
rs1221633501	p.Ser19Cys	missense variant	-	NC_000016.10:g.68738304C>G	TOPMed,gnomAD
NCI-TCGA novel	p.Ser19ProPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68738300_68738301insCA	NCI-TCGA
NCI-TCGA novel	p.Ser19ArgPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68738300_68738301insCAAGA	NCI-TCGA
RCV000013026	p.Trp20Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738307G>A	ClinVar
rs121964875	p.Trp20Ter	stop gained	-	NC_000016.10:g.68738307G>A	-
rs786203576	p.Trp20Ter	stop gained	-	NC_000016.10:g.68738308G>A	-
RCV000166954	p.Trp20Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738308G>A	ClinVar
RCV000639276	p.Leu21Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738309C>A	ClinVar
RCV000199237	p.Leu21Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738309C>T	ClinVar
RCV000213718	p.Leu21Ile	missense variant	-	NC_000016.10:g.68738309C>A	ClinVar
rs863224729	p.Leu21Val	missense variant	-	NC_000016.10:g.68738309C>G	TOPMed,gnomAD
rs863224729	p.Leu21Phe	missense variant	-	NC_000016.10:g.68738309C>T	TOPMed,gnomAD
RCV000456561	p.Leu21Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738309C>G	ClinVar
RCV000222019	p.Leu21Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738309C>G	ClinVar
RCV000486805	p.Leu21Pro	missense variant	-	NC_000016.10:g.68738310T>C	ClinVar
rs863224729	p.Leu21Ile	missense variant	-	NC_000016.10:g.68738309C>A	TOPMed,gnomAD
rs1064794920	p.Leu21Pro	missense variant	-	NC_000016.10:g.68738310T>C	-
RCV000575835	p.Cys22Tyr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738313G>A	ClinVar
rs865838543	p.Cys22Ter	stop gained	-	NC_000016.10:g.68738314C>A	gnomAD
rs1555509758	p.Cys22Tyr	missense variant	-	NC_000016.10:g.68738313G>A	-
COSM19503	p.Gln23Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68738315C>T	NCI-TCGA Cosmic
RCV000013027	p.Glu24Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738318G>T	ClinVar
rs121964876	p.Glu24Ter	stop gained	-	NC_000016.10:g.68738318G>T	-
rs1485238301	p.Pro25Leu	missense variant	-	NC_000016.10:g.68738322C>T	gnomAD
RCV000797095	p.Glu26Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738324G>T	ClinVar
RCV000162463	p.Glu26Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738324G>T	ClinVar
RCV000223374	p.Glu26Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738324G>C	ClinVar
rs786201058	p.Glu26Gln	missense variant	-	NC_000016.10:g.68738324G>C	-
rs786201058	p.Glu26Ter	stop gained	-	NC_000016.10:g.68738324G>T	-
RCV000410130	p.Glu26Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738324G>C	ClinVar
RCV000679582	p.Pro27Ser	missense variant	-	NC_000016.10:g.68738327C>T	ClinVar
RCV000582299	p.Pro27Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738327C>T	ClinVar
RCV000226798	p.Pro27Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738327C>T	ClinVar
rs878854696	p.Pro27Ser	missense variant	-	NC_000016.10:g.68738327C>T	-
rs587780789	p.Cys28Ter	stop gained	-	NC_000016.10:g.68738332C>A	TOPMed,gnomAD
RCV000772600	p.His29Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738334A>G	ClinVar
RCV000639282	p.His29Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738334A>G	ClinVar
rs1555509761	p.His29Arg	missense variant	-	NC_000016.10:g.68738334A>G	-
RCV000698861	p.His29Tyr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738333C>T	ClinVar
rs1254266267	p.His29Tyr	missense variant	-	NC_000016.10:g.68738333C>T	gnomAD
RCV000214994	p.Pro30Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738337C>G	ClinVar
rs876660408	p.Pro30Arg	missense variant	-	NC_000016.10:g.68738337C>G	gnomAD
RCV000123256	p.Pro30Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738336C>A	ClinVar
rs139866691	p.Pro30Thr	missense variant	-	NC_000016.10:g.68738336C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000639264	p.Gly31Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738340G>T	ClinVar
rs1131690823	p.Gly31Val	missense variant	-	NC_000016.10:g.68738340G>T	-
RCV000492686	p.Gly31Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738340G>T	ClinVar
rs1382043754	p.Phe32Leu	missense variant	-	NC_000016.10:g.68738342T>C	TOPMed
rs1486768673	p.Ala34Ser	missense variant	-	NC_000016.10:g.68738348G>T	gnomAD
rs1486768673	p.Ala34Thr	missense variant	-	NC_000016.10:g.68738348G>A	gnomAD
RCV000555305	p.Ala34Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738348G>T	ClinVar
RCV000478504	p.Glu35Asp	missense variant	-	NC_000016.10:g.68738353G>C	ClinVar
RCV000691907	p.Glu35Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738353G>C	ClinVar
rs876660131	p.Glu35Asp	missense variant	-	NC_000016.10:g.68738353G>C	-
RCV000562387	p.Glu35Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738353G>C	ClinVar
RCV000479808	p.Ser36Asn	missense variant	-	NC_000016.10:g.68738355G>A	ClinVar
COSM435584	p.Ser36AlaPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68738354A>-	NCI-TCGA Cosmic
RCV000573106	p.Ser36Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738354A>G	ClinVar
rs1555509773	p.Ser36Gly	missense variant	-	NC_000016.10:g.68738354A>G	-
rs1064794682	p.Ser36Ile	missense variant	-	NC_000016.10:g.68738355G>T	TOPMed,gnomAD
rs1064794682	p.Ser36Asn	missense variant	-	NC_000016.10:g.68738355G>A	TOPMed,gnomAD
RCV000579397	p.Thr38Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738360A>C	ClinVar
RCV000166751	p.Thr38Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738360A>G	ClinVar
RCV000120507	p.Thr38Met	missense variant	-	NC_000016.10:g.68738361C>T	ClinVar
RCV000536623	p.Thr38Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738361C>A	ClinVar
rs786203442	p.Thr38Ala	missense variant	-	NC_000016.10:g.68738360A>G	gnomAD
rs587778171	p.Thr38Met	missense variant	-	NC_000016.10:g.68738361C>T	ExAC,TOPMed,gnomAD
RCV000686759	p.Thr38Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738360A>C	ClinVar
rs786203442	p.Thr38Pro	missense variant	-	NC_000016.10:g.68738360A>C	gnomAD
rs587778171	p.Thr38Lys	missense variant	-	NC_000016.10:g.68738361C>A	ExAC,TOPMed,gnomAD
RCV000222770	p.Thr38Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738361C>A	ClinVar
RCV000218039	p.Thr40Ser	missense variant	-	NC_000016.10:g.68738366A>T	ClinVar
rs876661278	p.Thr40Ser	missense variant	-	NC_000016.10:g.68738366A>T	-
RCV000688401	p.Val41Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738369G>T	ClinVar
RCV000165286	p.Val41Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738369G>A	ClinVar
RCV000567291	p.Val41Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738369G>T	ClinVar
rs786202465	p.Val41Met	missense variant	-	NC_000016.10:g.68738369G>A	-
rs786202465	p.Val41Leu	missense variant	-	NC_000016.10:g.68738369G>T	-
RCV000461065	p.Pro42Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738373C>T	ClinVar
RCV000215517	p.Pro42Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738372_68738374delinsT	ClinVar
RCV000759726	p.Pro42Leu	missense variant	-	NC_000016.10:g.68738373C>T	ClinVar
RCV000214968	p.Pro42Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738373C>T	ClinVar
rs876659333	p.Pro42Leu	missense variant	-	NC_000016.10:g.68738373C>T	TOPMed,gnomAD
RCV000566670	p.Arg44Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738379G>T	ClinVar
rs1375178645	p.Arg44Leu	missense variant	-	NC_000016.10:g.68738379G>T	gnomAD
rs1375178645	p.Arg44His	missense variant	-	NC_000016.10:g.68738379G>A	gnomAD
rs1555509778	p.Leu46Pro	missense variant	-	NC_000016.10:g.68738385T>C	-
RCV000571979	p.Leu46Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738385T>C	ClinVar
rs1308247672	p.Glu47Asp	missense variant	-	NC_000016.10:g.68738389G>C	gnomAD
RCV000473027	p.Gly49Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738393G>A	ClinVar
rs1060501223	p.Gly49Ser	missense variant	-	NC_000016.10:g.68738393G>A	gnomAD
RCV000562899	p.Gly49Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738393G>C	ClinVar
rs1060501223	p.Gly49Arg	missense variant	-	NC_000016.10:g.68738393G>C	gnomAD
NCI-TCGA novel	p.Gly49Cys	missense variant	-	NC_000016.10:g.68738393G>T	NCI-TCGA
RCV000216058	p.Arg50Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738396C>A	ClinVar
rs876659739	p.Arg50Ser	missense variant	-	NC_000016.10:g.68738396C>A	-
rs1555509780	p.Val51Ile	missense variant	-	NC_000016.10:g.68738399G>A	-
rs1555509780	p.Val51Ile	missense variant	-	NC_000016.10:g.68738399G>A	NCI-TCGA
RCV000575586	p.Val51Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738399G>A	ClinVar
rs374569322	p.Leu52Val	missense variant	-	NC_000016.10:g.68738402C>G	TOPMed
rs1367719041	p.Leu52Gln	missense variant	-	NC_000016.10:g.68738403T>A	gnomAD
RCV000222464	p.Gly53Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738406G>C	ClinVar
rs876659692	p.Gly53Asp	missense variant	-	NC_000016.10:g.68738406G>A	-
RCV000580029	p.Gly53Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738406G>A	ClinVar
rs876659692	p.Gly53Ala	missense variant	-	NC_000016.10:g.68738406G>C	-
RCV000474006	p.Arg54Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738408A>G	ClinVar
rs876658680	p.Arg54Lys	missense variant	-	NC_000016.10:g.68738409G>A	gnomAD
RCV000215888	p.Arg54Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738409G>A	ClinVar
rs587781329	p.Arg54Gly	missense variant	-	NC_000016.10:g.68738408A>G	ExAC,TOPMed,gnomAD
RCV000549869	p.Arg54Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68738409G>A	ClinVar
RCV000212346	p.Arg54Gly	missense variant	-	NC_000016.10:g.68738408A>G	ClinVar
RCV000129074	p.Arg54Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68738408A>G	ClinVar
NCI-TCGA novel	p.Arg54GlnPheSerTerUnk	frameshift	-	NC_000016.10:g.68738403_68738404insG	NCI-TCGA
RCV000131233	p.Val55Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801670T>G	ClinVar
RCV000469215	p.Val55Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801670T>C	ClinVar
rs587778174	p.Val55Gly	missense variant	-	NC_000016.10:g.68801670T>G	ExAC,TOPMed,gnomAD
rs587778174	p.Val55Ala	missense variant	-	NC_000016.10:g.68801670T>C	ExAC,TOPMed,gnomAD
rs1060501227	p.Asn56Asp	missense variant	-	NC_000016.10:g.68801672A>G	-
RCV000473205	p.Asn56Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801672A>G	ClinVar
RCV000572545	p.Glu58Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801678G>A	ClinVar
rs1060501234	p.Glu58Lys	missense variant	-	NC_000016.10:g.68801678G>A	-
RCV000483154	p.Glu58Val	missense variant	-	NC_000016.10:g.68801679A>T	ClinVar
RCV000471758	p.Glu58Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801679A>T	ClinVar
RCV000460113	p.Glu58Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801678G>A	ClinVar
rs786202570	p.Glu58Val	missense variant	-	NC_000016.10:g.68801679A>T	-
RCV000165435	p.Glu58Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801679A>T	ClinVar
RCV000115847	p.Asp59Glu	missense variant	-	NC_000016.10:g.68801683T>G	ClinVar
RCV000234870	p.Asp59Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801683T>G	ClinVar
RCV000411078	p.Asp59Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801683T>G	ClinVar
rs587780116	p.Asp59Glu	missense variant	-	NC_000016.10:g.68801683T>G	ExAC,TOPMed,gnomAD
RCV000167156	p.Gly62Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801691G>T	ClinVar
RCV000793742	p.Gly62Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801691G>T	ClinVar
RCV000589761	p.Gly62Ser	missense variant	-	NC_000016.10:g.68801690G>A	ClinVar
RCV000130235	p.Gly62Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801690G>A	ClinVar
rs786203727	p.Gly62Asp	missense variant	-	NC_000016.10:g.68801691G>A	TOPMed
rs786203727	p.Gly62Val	missense variant	-	NC_000016.10:g.68801691G>T	TOPMed
rs587781898	p.Gly62Ser	missense variant	-	NC_000016.10:g.68801690G>A	ExAC,TOPMed,gnomAD
RCV000557834	p.Gly62Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801691G>A	ClinVar
RCV000232399	p.Gly62Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801690G>A	ClinVar
RCV000563489	p.Arg63Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801693C>T	ClinVar
RCV000679566	p.Arg63Gln	missense variant	-	NC_000016.10:g.68801694G>A	ClinVar
rs587783047	p.Arg63Ter	stop gained	-	NC_000016.10:g.68801693C>T	-
RCV000144590	p.Arg63Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801693C>T	ClinVar
rs587780117	p.Arg63Gln	missense variant	-	NC_000016.10:g.68801694G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg63Pro	missense variant	-	NC_000016.10:g.68801694G>C	NCI-TCGA
rs1478145907	p.Arg65Lys	missense variant	-	NC_000016.10:g.68801700G>A	TOPMed
RCV000204809	p.Ala67Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801706C>A	ClinVar
RCV000458777	p.Ala67Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801706C>G	ClinVar
RCV000574938	p.Ala67Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801705G>A	ClinVar
RCV000160381	p.Ala67Gly	missense variant	-	NC_000016.10:g.68801706C>G	ClinVar
rs1060501247	p.Ala67Thr	missense variant	-	NC_000016.10:g.68801705G>A	gnomAD
rs730881660	p.Ala67Asp	missense variant	-	NC_000016.10:g.68801706C>A	ExAC,TOPMed,gnomAD
RCV000218936	p.Ala67Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801706C>A	ClinVar
RCV000465459	p.Ala67Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801705G>A	ClinVar
rs730881660	p.Ala67Gly	missense variant	-	NC_000016.10:g.68801706C>G	ExAC,TOPMed,gnomAD
RCV000479101	p.Ala67Thr	missense variant	-	NC_000016.10:g.68801705G>A	ClinVar
RCV000164820	p.Tyr68Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801708del	ClinVar
RCV000479654	p.Tyr68Ter	frameshift	-	NC_000016.10:g.68801708del	ClinVar
RCV000463675	p.Tyr68Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801708T>G	ClinVar
RCV000685278	p.Tyr68Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801708del	ClinVar
RCV000566254	p.Tyr68Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801708T>G	ClinVar
rs1060501218	p.Tyr68Asp	missense variant	-	NC_000016.10:g.68801708T>G	-
rs1284989530	p.Tyr68Cys	missense variant	-	NC_000016.10:g.68801709A>G	gnomAD
RCV000774143	p.Phe69Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801711T>G	ClinVar
RCV000581916	p.Phe69Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801713T>G	ClinVar
rs1190318676	p.Phe69Leu	missense variant	-	NC_000016.10:g.68801713T>G	TOPMed
RCV000801913	p.Ser70Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801714T>C	ClinVar
rs587781862	p.Ser70Pro	missense variant	-	NC_000016.10:g.68801714T>C	TOPMed
RCV000204939	p.Ser70Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801714T>A	ClinVar
RCV000657349	p.Ser70Ter	frameshift	-	NC_000016.10:g.68801714dup	ClinVar
RCV000545409	p.Ser70Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801714dup	ClinVar
rs587781862	p.Ser70Thr	missense variant	-	NC_000016.10:g.68801714T>A	TOPMed
RCV000130176	p.Ser70Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801714T>C	ClinVar
NCI-TCGA novel	p.Ser70ProPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68801710T>-	NCI-TCGA
RCV000639265	p.Leu71Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801717C>A	ClinVar
COSM704381	p.Leu71Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68801717C>T	NCI-TCGA Cosmic
rs1555514408	p.Leu71Ile	missense variant	-	NC_000016.10:g.68801717C>A	-
NCI-TCGA novel	p.Leu71SerPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68801715C>-	NCI-TCGA
RCV000123243	p.Asp72Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801720G>A	ClinVar
RCV000656818	p.Asp72Asn	missense variant	-	NC_000016.10:g.68801720G>A	ClinVar
rs35606263	p.Asp72Asn	missense variant	-	NC_000016.10:g.68801720G>A	UniProt,dbSNP
VAR_048500	p.Asp72Asn	missense variant	-	NC_000016.10:g.68801720G>A	UniProt
rs35606263	p.Asp72Asn	missense variant	-	NC_000016.10:g.68801720G>A	ESP,ExAC,TOPMed,gnomAD
rs35606263	p.Asp72His	missense variant	-	NC_000016.10:g.68801720G>C	ESP,ExAC,TOPMed,gnomAD
RCV000565286	p.Thr73Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801724C>A	ClinVar
RCV000774144	p.Thr73Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801724C>T	ClinVar
RCV000707243	p.Thr73Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801724C>A	ClinVar
rs1555514410	p.Thr73Asn	missense variant	-	NC_000016.10:g.68801724C>A	-
RCV000763384	p.Arg74Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801726C>T	ClinVar
RCV000567326	p.Arg74Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801727G>A	ClinVar
RCV000524812	p.Arg74Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801727G>C	ClinVar
rs761562625	p.Arg74Pro	missense variant	-	NC_000016.10:g.68801727G>C	ExAC,gnomAD
RCV000227616	p.Arg74Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801726C>T	ClinVar
RCV000639229	p.Arg74Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801727G>T	ClinVar
RCV000550917	p.Arg74Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801727G>A	ClinVar
rs761562625	p.Arg74Leu	missense variant	-	NC_000016.10:g.68801727G>T	ExAC,gnomAD
rs876658932	p.Arg74Ter	stop gained	-	NC_000016.10:g.68801726C>T	TOPMed
rs761562625	p.Arg74Gln	missense variant	-	NC_000016.10:g.68801727G>A	ExAC,gnomAD
rs876658932	p.Arg74Gly	missense variant	-	NC_000016.10:g.68801726C>G	TOPMed
RCV000567709	p.Arg74Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801726C>T	ClinVar
RCV000687009	p.Arg74Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801726C>G	ClinVar
RCV000218864	p.Arg74Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801726C>G	ClinVar
NCI-TCGA novel	p.Arg74ProPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68801723_68801724insC	NCI-TCGA
RCV000464249	p.Phe75Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801731C>G	ClinVar
RCV000129093	p.Phe75Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801730T>G	ClinVar
RCV000581517	p.Phe75Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801731C>A	ClinVar
rs587781336	p.Phe75Cys	missense variant	-	NC_000016.10:g.68801730T>G	-
rs767019668	p.Phe75Leu	missense variant	-	NC_000016.10:g.68801731C>G	ExAC,TOPMed,gnomAD
rs587782193	p.Phe75Leu	missense variant	-	NC_000016.10:g.68801729T>C	gnomAD
RCV000554536	p.Phe75Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801729T>C	ClinVar
rs767019668	p.Phe75Leu	missense variant	-	NC_000016.10:g.68801731C>A	ExAC,TOPMed,gnomAD
rs1260273251	p.Lys76Asn	missense variant	-	NC_000016.10:g.68801734A>C	gnomAD
RCV000679570	p.Gly78Asp	missense variant	-	NC_000016.10:g.68801739G>A	ClinVar
RCV000230648	p.Gly78Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801739G>A	ClinVar
rs587781404	p.Gly78Asp	missense variant	-	NC_000016.10:g.68801739G>A	TOPMed
rs864622477	p.Gly78Ser	missense variant	-	NC_000016.10:g.68801738G>A	-
RCV000205065	p.Gly78Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801738G>A	ClinVar
RCV000129255	p.Gly78Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801739G>A	ClinVar
RCV000217533	p.Thr79Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801742C>G	ClinVar
rs876658359	p.Thr79Arg	missense variant	-	NC_000016.10:g.68801742C>G	-
RCV000571275	p.Asp80His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801744G>C	ClinVar
rs1555514423	p.Asp80His	missense variant	-	NC_000016.10:g.68801744G>C	-
RCV000477208	p.Gly81Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801747G>A	ClinVar
rs1060501225	p.Gly81Ser	missense variant	-	NC_000016.10:g.68801747G>A	-
RCV000639230	p.Val82Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801750G>A	ClinVar
RCV000482425	p.Val82Met	missense variant	-	NC_000016.10:g.68801750G>A	ClinVar
rs942284129	p.Val82Gly	missense variant	-	NC_000016.10:g.68801751T>G	TOPMed
RCV000775708	p.Val82Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801750G>T	ClinVar
rs1064793867	p.Val82Met	missense variant	-	NC_000016.10:g.68801750G>A	gnomAD
RCV000569606	p.Thr84Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801757C>T	ClinVar
RCV000204522	p.Thr84Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801757C>T	ClinVar
RCV000480914	p.Thr84Ile	missense variant	-	NC_000016.10:g.68801757C>T	ClinVar
rs754388534	p.Thr84Ile	missense variant	-	NC_000016.10:g.68801757C>T	ExAC,TOPMed,gnomAD
RCV000587445	p.Val85Ala	missense variant	-	NC_000016.10:g.68801760T>C	ClinVar
RCV000565577	p.Val85Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801759G>A	ClinVar
rs878854688	p.Val85Ala	missense variant	-	NC_000016.10:g.68801760T>C	TOPMed
rs1555514427	p.Val85Ile	missense variant	-	NC_000016.10:g.68801759G>A	-
RCV000569815	p.Val85Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801760T>C	ClinVar
RCV000229392	p.Val85Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801760T>C	ClinVar
rs1160169015	p.Lys86Arg	missense variant	-	NC_000016.10:g.68801763A>G	gnomAD
RCV000584323	p.Lys86Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801763A>G	ClinVar
RCV000227212	p.Arg87Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801767G>C	ClinVar
RCV000574364	p.Arg87Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801767G>C	ClinVar
RCV000532595	p.Arg87Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801767del	ClinVar
COSM5205425	p.Arg87AlaPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68801762_68801763AA>-	NCI-TCGA Cosmic
rs878854689	p.Arg87Ser	missense variant	-	NC_000016.10:g.68801767G>C	-
RCV000799734	p.Pro88Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801769C>G	ClinVar
COSM1379140	p.Pro88His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68801769C>A	NCI-TCGA Cosmic
RCV000463685	p.Pro88Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801768C>T	ClinVar
RCV000565051	p.Pro88Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801769C>G	ClinVar
rs779313390	p.Pro88Ser	missense variant	-	NC_000016.10:g.68801768C>T	ExAC,gnomAD
rs1381409755	p.Pro88Arg	missense variant	-	NC_000016.10:g.68801769C>G	TOPMed,gnomAD
rs779313390	p.Pro88Thr	missense variant	-	NC_000016.10:g.68801768C>A	ExAC,gnomAD
RCV000557751	p.Pro88Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801768C>A	ClinVar
RCV000410067	p.Arg90Trp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801774C>T	ClinVar
RCV000212347	p.Arg90Trp	missense variant	-	NC_000016.10:g.68801774C>T	ClinVar
RCV000160382	p.Arg90Trp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801774C>T	ClinVar
rs1555514433	p.Arg90Pro	missense variant	-	NC_000016.10:g.68801775_68801776delinsCA	-
RCV000571292	p.Arg90Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801775_68801776delinsCA	ClinVar
RCV000200245	p.Arg90Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801775G>A	ClinVar
rs730881661	p.Arg90Trp	missense variant	-	NC_000016.10:g.68801774C>T	TOPMed,gnomAD
rs587782647	p.Arg90Gln	missense variant	-	NC_000016.10:g.68801775G>A	ExAC,TOPMed,gnomAD
RCV000482830	p.Arg90Gln	missense variant	-	NC_000016.10:g.68801775G>A	ClinVar
RCV000639211	p.His92Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801782T>G	ClinVar
rs770967343	p.His92Gln	missense variant	-	NC_000016.10:g.68801782T>G	ExAC,gnomAD
RCV000773200	p.Pro94Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801786C>T	ClinVar
RCV000481538	p.Pro94Ser	missense variant	-	NC_000016.10:g.68801786C>T	ClinVar
RCV000781217	p.Pro94Arg	missense variant	-	NC_000016.10:g.68801787C>G	ClinVar
rs1064793862	p.Pro94Ser	missense variant	-	NC_000016.10:g.68801786C>T	-
RCV000546548	p.Gln95Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801789C>T	ClinVar
rs781409616	p.Gln95Ter	stop gained	-	NC_000016.10:g.68801789C>T	ExAC,gnomAD
rs749306433	p.Ile96Phe	missense variant	-	NC_000016.10:g.68801792A>T	ExAC,gnomAD
RCV000205362	p.Ile96Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801792A>G	ClinVar
RCV000165180	p.Ile96Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801792A>T	ClinVar
RCV000473818	p.Ile96Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801792A>T	ClinVar
rs768648027	p.Ile96Met	missense variant	-	NC_000016.10:g.68801794C>G	ExAC,gnomAD
rs749306433	p.Ile96Val	missense variant	-	NC_000016.10:g.68801792A>G	ExAC,gnomAD
RCV000120510	p.His97Asp	missense variant	-	NC_000016.10:g.68801795C>G	ClinVar
RCV000572193	p.Phe98Tyr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801799T>A	ClinVar
rs1177900932	p.Phe98Leu	missense variant	-	NC_000016.10:g.68801800C>A	TOPMed
rs1555514451	p.Phe98Tyr	missense variant	-	NC_000016.10:g.68801799T>A	-
rs1177900932	p.Phe98Leu	missense variant	-	NC_000016.10:g.68801800C>A	NCI-TCGA Cosmic
RCV000775935	p.Val100Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801804G>A	ClinVar
RCV000821233	p.Val100Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801804G>A	ClinVar
RCV000690751	p.Val100Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801805T>C	ClinVar
RCV000572185	p.Val100Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801805T>C	ClinVar
rs1555514454	p.Val100Ala	missense variant	-	NC_000016.10:g.68801805T>C	-
rs1064793437	p.Val100Ile	missense variant	-	NC_000016.10:g.68801804G>A	-
RCV000479592	p.Val100Ile	missense variant	-	NC_000016.10:g.68801804G>A	ClinVar
rs774301557	p.Tyr101His	missense variant	-	NC_000016.10:g.68801807T>C	ExAC,gnomAD
NCI-TCGA novel	p.Tyr101Cys	missense variant	-	NC_000016.10:g.68801808A>G	NCI-TCGA
RCV000165626	p.Ala102Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801811C>T	ClinVar
RCV000583486	p.Ala102Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801811C>G	ClinVar
RCV000479588	p.Ala102Ser	missense variant	-	NC_000016.10:g.68801810G>T	ClinVar
rs368492235	p.Ala102Ser	missense variant	-	NC_000016.10:g.68801810G>T	ExAC,TOPMed,gnomAD
RCV000167482	p.Ala102Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801810G>T	ClinVar
RCV000639246	p.Ala102Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801810G>T	ClinVar
RCV000374968	p.Ala102Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801810G>A	ClinVar
RCV000131780	p.Ala102Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801810G>A	ClinVar
rs368492235	p.Ala102Thr	missense variant	-	NC_000016.10:g.68801810G>A	NCI-TCGA,NCI-TCGA Cosmic
rs786202689	p.Ala102Gly	missense variant	-	NC_000016.10:g.68801811C>G	gnomAD
rs368492235	p.Ala102Thr	missense variant	-	NC_000016.10:g.68801810G>A	ExAC,TOPMed,gnomAD
rs786202689	p.Ala102Val	missense variant	-	NC_000016.10:g.68801811C>T	gnomAD
RCV000567076	p.Trp103Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801814G>A	ClinVar
rs550619440	p.Trp103Arg	missense variant	-	NC_000016.10:g.68801813T>A	gnomAD
RCV000807991	p.Trp103Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801814G>A	ClinVar
rs1555514464	p.Trp103Ter	stop gained	-	NC_000016.10:g.68801814G>A	-
rs760351575	p.Asp104Val	missense variant	-	NC_000016.10:g.68801817A>T	ExAC
RCV000777364	p.Ser105Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801819T>A	ClinVar
RCV000639260	p.Ser105Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801819T>A	ClinVar
rs1165815510	p.Ser105Thr	missense variant	-	NC_000016.10:g.68801819T>A	TOPMed
RCV000115861	p.Thr106Ala	missense variant	-	NC_000016.10:g.68801822A>G	ClinVar
RCV000486371	p.Thr106Ter	frameshift	-	NC_000016.10:g.68801821del	ClinVar
rs587780122	p.Thr106Ala	missense variant	-	NC_000016.10:g.68801822A>G	-
RCV000575896	p.Tyr107Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801826A>G	ClinVar
RCV000468950	p.Tyr107Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801826A>G	ClinVar
rs1060501241	p.Tyr107Cys	missense variant	-	NC_000016.10:g.68801826A>G	-
RCV000120509	p.Arg108Gly	missense variant	-	NC_000016.10:g.68801828A>G	ClinVar
rs587778172	p.Arg108Gly	missense variant	-	NC_000016.10:g.68801828A>G	ExAC,gnomAD
NCI-TCGA novel	p.Arg108HisPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68801827_68801837CAGAAAGTTTT>-	NCI-TCGA
RCV000487251	p.Lys109Gln	missense variant	-	NC_000016.10:g.68801831A>C	ClinVar
RCV000130456	p.Lys109Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801831A>C	ClinVar
RCV000463382	p.Lys109Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801831A>C	ClinVar
rs587782023	p.Lys109Gln	missense variant	-	NC_000016.10:g.68801831A>C	TOPMed,gnomAD
RCV000700206	p.Ser111Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801838C>T	ClinVar
RCV000572873	p.Lys113Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801843A>G	ClinVar
RCV000463944	p.Lys113Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801843A>G	ClinVar
rs876661106	p.Lys113Glu	missense variant	-	NC_000016.10:g.68801843A>G	NCI-TCGA Cosmic
rs876661106	p.Lys113Ter	stop gained	-	NC_000016.10:g.68801843A>T	gnomAD
rs876661106	p.Lys113Glu	missense variant	-	NC_000016.10:g.68801843A>G	gnomAD
RCV000220040	p.Lys113Ter	nonsense	-	NC_000016.10:g.68801843A>T	ClinVar
RCV000217135	p.Lys113Glu	missense variant	-	NC_000016.10:g.68801843A>G	ClinVar
RCV000129106	p.Thr115Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801850C>T	ClinVar
RCV000212350	p.Thr115Met	missense variant	-	NC_000016.10:g.68801850C>T	ClinVar
RCV000197330	p.Thr115Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801850C>T	ClinVar
rs370973869	p.Thr115Met	missense variant	-	NC_000016.10:g.68801850C>T	ESP,ExAC,TOPMed,gnomAD
RCV000772201	p.Asn117Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801856A>G	ClinVar
RCV000774762	p.Asn117Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801856A>T	ClinVar
rs758733846	p.Asn117Ile	missense variant	-	NC_000016.10:g.68801856A>T	ExAC,gnomAD
RCV000556819	p.Thr118Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801858A>G	ClinVar
rs1555514476	p.Thr118Ala	missense variant	-	NC_000016.10:g.68801858A>G	-
RCV000132103	p.Thr118Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801859C>G	ClinVar
rs587782677	p.Thr118Arg	missense variant	-	NC_000016.10:g.68801859C>G	-
RCV000639245	p.Val119Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801861G>A	ClinVar
RCV000167336	p.Val119Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801861G>A	ClinVar
rs786203849	p.Val119Met	missense variant	-	NC_000016.10:g.68801861G>A	-
RCV000487213	p.Val119Met	missense variant	-	NC_000016.10:g.68801861G>A	ClinVar
RCV000213499	p.Gly120Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801864G>A	ClinVar
rs751789834	p.Gly120Arg	missense variant	-	NC_000016.10:g.68801864G>A	ExAC,gnomAD
RCV000777110	p.His121Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801869C>G	ClinVar
RCV000227876	p.His121Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801866dup	ClinVar
rs781427897	p.His121Gln	missense variant	-	NC_000016.10:g.68801869C>A	ExAC,gnomAD
rs1305026083	p.His121Asn	missense variant	-	NC_000016.10:g.68801867C>A	gnomAD
RCV000217115	p.His122Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801872C>G	ClinVar
rs140123339	p.His122Gln	missense variant	-	NC_000016.10:g.68801872C>G	ESP
rs528816701	p.His122Tyr	missense variant	-	NC_000016.10:g.68801870C>T	ExAC,gnomAD
RCV000582606	p.His122Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801871A>G	ClinVar
rs373668742	p.His122Arg	missense variant	-	NC_000016.10:g.68801871A>G	ESP,ExAC,gnomAD
rs528816701	p.His122Asp	missense variant	-	NC_000016.10:g.68801870C>G	ExAC,gnomAD
RCV000639287	p.His122Tyr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801870C>T	ClinVar
RCV000165782	p.His123Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801874A>G	ClinVar
RCV000166535	p.His123Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801875C>G	ClinVar
rs778954591	p.His123Gln	missense variant	-	NC_000016.10:g.68801875C>G	ExAC,TOPMed,gnomAD
RCV000639233	p.His123Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801873C>A	ClinVar
rs1555514482	p.His123Asn	missense variant	-	NC_000016.10:g.68801873C>A	-
rs786202794	p.His123Arg	missense variant	-	NC_000016.10:g.68801874A>G	TOPMed
RCV000639218	p.His123Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801875C>G	ClinVar
RCV000703362	p.His123Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801874A>G	ClinVar
VAR_001306	p.His123Tyr	Missense	-	-	UniProt
rs748086082	p.Arg124Cys	missense variant	-	NC_000016.10:g.68801876C>T	NCI-TCGA
RCV000235150	p.Arg124His	missense variant	-	NC_000016.10:g.68801877G>A	ClinVar
RCV000565531	p.Arg124Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801876C>T	ClinVar
rs748086082	p.Arg124Cys	missense variant	-	NC_000016.10:g.68801876C>T	ExAC,TOPMed,gnomAD
rs115418995	p.Arg124His	missense variant	-	NC_000016.10:g.68801877G>A	NCI-TCGA
RCV000639206	p.Arg124Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801877G>C	ClinVar
RCV000535278	p.Arg124His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801877G>A	ClinVar
RCV000130746	p.Arg124Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801877G>C	ClinVar
rs115418995	p.Arg124Leu	missense variant	-	NC_000016.10:g.68801877G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs115418995	p.Arg124His	missense variant	-	NC_000016.10:g.68801877G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs115418995	p.Arg124Pro	missense variant	-	NC_000016.10:g.68801877G>C	1000Genomes,ExAC,TOPMed,gnomAD
RCV000732060	p.Arg124His	missense variant	-	NC_000016.10:g.68801877G>A	ClinVar
RCV000160383	p.Pro125Ser	missense variant	-	NC_000016.10:g.68801879C>T	ClinVar
rs730881662	p.Pro125Ser	missense variant	-	NC_000016.10:g.68801879C>T	TOPMed,gnomAD
RCV000217007	p.Pro125Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801879C>T	ClinVar
RCV000809535	p.Pro125Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801879C>T	ClinVar
RCV000679573	p.Pro126Leu	missense variant	-	NC_000016.10:g.68801883C>T	ClinVar
RCV000587043	p.Pro126Arg	missense variant	-	NC_000016.10:g.68801883C>G	ClinVar
RCV000535540	p.Pro126Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801883C>A	ClinVar
rs746703615	p.Pro126Leu	missense variant	-	NC_000016.10:g.68801883C>T	ExAC,TOPMed,gnomAD
rs746703615	p.Pro126Arg	missense variant	-	NC_000016.10:g.68801883C>G	ExAC,TOPMed,gnomAD
COSM19494	p.Pro126ArgPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68801878C>-	NCI-TCGA Cosmic
RCV000465184	p.Pro126Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801883C>T	ClinVar
RCV000163916	p.Pro126Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801883C>T	ClinVar
RCV000765302	p.Pro126Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801883C>T	ClinVar
RCV000557094	p.Pro126Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801882C>T	ClinVar
RCV000473473	p.Pro126Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801883del	ClinVar
rs746703615	p.Pro126Gln	missense variant	-	NC_000016.10:g.68801883C>A	ExAC,TOPMed,gnomAD
rs1555514491	p.Pro126Ser	missense variant	-	NC_000016.10:g.68801882C>T	-
RCV000507242	p.Pro126Ter	frameshift	-	NC_000016.10:g.68801883del	ClinVar
COSM20785	p.Pro127AlaPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68801877_68801878insC	NCI-TCGA Cosmic
RCV000477167	p.Pro127Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801885C>A	ClinVar
rs1060501250	p.Pro127Thr	missense variant	-	NC_000016.10:g.68801885C>A	-
RCV000822348	p.His128Tyr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801888C>T	ClinVar
RCV000571499	p.His128Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801888del	ClinVar
RCV000576815	p.His128Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801888del	ClinVar
RCV000582729	p.His128Tyr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68801888C>T	ClinVar
RCV000508524	p.His128Tyr	missense variant	-	NC_000016.10:g.68801888C>T	ClinVar
RCV000687705	p.His128Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68801875_68801881CCGCCCC[3]	ClinVar
rs376152506	p.His128Tyr	missense variant	-	NC_000016.10:g.68801888C>T	ESP,ExAC,TOPMed,gnomAD
rs764700595	p.Gln129His	missense variant	-	NC_000016.10:g.68801893G>T	ExAC,gnomAD
rs764700595	p.Gln129His	missense variant	-	NC_000016.10:g.68801893G>T	NCI-TCGA,NCI-TCGA Cosmic
NCI-TCGA novel	p.Gln129Ter	stop gained	-	NC_000016.10:g.68801891C>T	NCI-TCGA
RCV000221311	p.Val132Ile	missense variant	-	NC_000016.10:g.68808430G>A	ClinVar
RCV000204503	p.Val132Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808430G>A	ClinVar
rs142498771	p.Val132Ile	missense variant	-	NC_000016.10:g.68808430G>A	ESP,ExAC,TOPMed,gnomAD
COSM417306	p.Ser133Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68808434C>T	NCI-TCGA Cosmic
rs1060501220	p.Gly134Arg	missense variant	-	NC_000016.10:g.68808436G>A	-
RCV000474205	p.Gly134Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808436G>A	ClinVar
RCV000574925	p.Ile135Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808440T>A	ClinVar
rs1047878465	p.Ile135Met	missense variant	-	NC_000016.10:g.68808441C>G	-
RCV000519747	p.Ile135Met	missense variant	-	NC_000016.10:g.68808441C>G	ClinVar
rs1555515189	p.Ile135Asn	missense variant	-	NC_000016.10:g.68808440T>A	-
RCV000563197	p.Gln136Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808443A>C	ClinVar
RCV000780093	p.Gln136Lys	missense variant	-	NC_000016.10:g.68808442C>A	ClinVar
RCV000777317	p.Gln136Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808443A>G	ClinVar
rs1184630483	p.Gln136Arg	missense variant	-	NC_000016.10:g.68808443A>G	gnomAD
rs753886948	p.Gln136Lys	missense variant	-	NC_000016.10:g.68808442C>A	ExAC,gnomAD
rs1184630483	p.Gln136Pro	missense variant	-	NC_000016.10:g.68808443A>C	gnomAD
RCV000703074	p.Gln136Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808443A>G	ClinVar
RCV000775844	p.Ala137Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808445G>A	ClinVar
RCV000223635	p.Ala137Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808445G>C	ClinVar
rs876658797	p.Ala137Pro	missense variant	-	NC_000016.10:g.68808445G>C	-
RCV000466626	p.Ala137Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808445G>C	ClinVar
rs864622284	p.Glu138Gly	missense variant	-	NC_000016.10:g.68808449A>G	-
RCV000205131	p.Glu138Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808449A>G	ClinVar
rs1057521858	p.Leu139Phe	missense variant	-	NC_000016.10:g.68808453G>C	TOPMed
rs758277885	p.Leu140Phe	missense variant	-	NC_000016.10:g.68808454C>T	ExAC,gnomAD
NCI-TCGA novel	p.Thr141ArgPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68808456_68808489CACATTTCCCAACTCCTCTCCTGGCCTCAGAAGA>-	NCI-TCGA
RCV000639272	p.Pro143Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808464C>T	ClinVar
RCV000215248	p.Pro143Ser	missense variant	-	NC_000016.10:g.68808463C>T	ClinVar
rs777714207	p.Pro143His	missense variant	-	NC_000016.10:g.68808464C>A	ExAC,gnomAD
rs777714207	p.Pro143Leu	missense variant	-	NC_000016.10:g.68808464C>T	ExAC,gnomAD
rs876661226	p.Pro143Ser	missense variant	-	NC_000016.10:g.68808463C>T	TOPMed,gnomAD
COSM5833140	p.Asn144ThrPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808466A>-	NCI-TCGA Cosmic
rs1460999478	p.Asn144Asp	missense variant	-	NC_000016.10:g.68808466A>G	gnomAD
RCV000625762	p.Ser146Cys	missense variant	Hereditary breast and ovarian cancer syndrome (HBOC)	NC_000016.10:g.68808473C>G	ClinVar
rs751425296	p.Ser146Cys	missense variant	-	NC_000016.10:g.68808473C>G	ExAC,gnomAD
RCV000131795	p.Pro147Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808476C>G	ClinVar
RCV000700071	p.Pro147Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808475C>T	ClinVar
RCV000583014	p.Pro147Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808472_68808473TC[1]	ClinVar
RCV000639257	p.Pro147Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808476C>G	ClinVar
rs587782571	p.Pro147Arg	missense variant	-	NC_000016.10:g.68808476C>G	ExAC,gnomAD
NCI-TCGA novel	p.Pro147HisPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68808453_68808454insCTCACATTTCCCAACTCCT	NCI-TCGA
RCV000801723	p.Gly148Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808478G>A	ClinVar
RCV000781212	p.Gly148Ser	missense variant	-	NC_000016.10:g.68808478G>A	ClinVar
RCV000410957	p.Leu149Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808482T>C	ClinVar
RCV000214362	p.Leu149Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808481C>A	ClinVar
RCV000166436	p.Leu149Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808482T>C	ClinVar
rs780955025	p.Leu149Pro	missense variant	-	NC_000016.10:g.68808482T>C	ExAC,gnomAD
rs876658781	p.Leu149Ile	missense variant	-	NC_000016.10:g.68808481C>A	-
rs1288704070	p.Arg150Gly	missense variant	-	NC_000016.10:g.68808484A>G	gnomAD
RCV000473387	p.Arg151Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808488G>T	ClinVar
rs1060501213	p.Arg151Ile	missense variant	-	NC_000016.10:g.68808488G>T	-
RCV000167046	p.Gln152His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808492G>C	ClinVar
RCV000570464	p.Gln152Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808490C>G	ClinVar
RCV000506785	p.Gln152Glu	missense variant	-	NC_000016.10:g.68808490C>G	ClinVar
RCV000584690	p.Gln152Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808491_68808501del	ClinVar
rs1555515211	p.Gln152Glu	missense variant	-	NC_000016.10:g.68808490C>G	-
RCV000657353	p.Gln152Ter	frameshift	-	NC_000016.10:g.68808491_68808501del	ClinVar
RCV000657322	p.Gln152Ter	frameshift	-	NC_000016.10:g.68808483_68808489CAGAAGA[1]	ClinVar
rs745589555	p.Gln152His	missense variant	-	NC_000016.10:g.68808492G>C	ExAC,TOPMed,gnomAD
rs1233421331	p.Gln152Arg	missense variant	-	NC_000016.10:g.68808491A>G	TOPMed
RCV000581892	p.Lys153Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808493_68808496del	ClinVar
RCV000689578	p.Lys153Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808493A>T	ClinVar
RCV000492486	p.Arg154Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808483_68808489CAGAAGA[3]	ClinVar
RCV000525870	p.Trp156Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808503G>A	ClinVar
RCV000218005	p.Trp156Ter	nonsense	-	NC_000016.10:g.68808504G>A	ClinVar
rs1555515215	p.Trp156Ter	stop gained	-	NC_000016.10:g.68808503G>A	-
rs876661107	p.Trp156Ter	stop gained	-	NC_000016.10:g.68808504G>A	-
rs587783046	p.Val157Ala	missense variant	-	NC_000016.10:g.68808506T>C	-
RCV000144589	p.Val157Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808506T>C	ClinVar
COSM435586	p.Pro159LeuPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808511C>-	NCI-TCGA Cosmic
COSM4062174	p.Pro159Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68808512C>T	NCI-TCGA Cosmic
COSM1479021	p.Pro160ArgPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808514_68808515insG	NCI-TCGA Cosmic
RCV000563868	p.Ile161Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808516_68808522delinsAGAATA	ClinVar
RCV000772852	p.Ser162Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808521G>T	ClinVar
RCV000484023	p.Cys163Ser	missense variant	-	NC_000016.10:g.68808524G>C	ClinVar
RCV000480530	p.Cys163Ter	nonsense	-	NC_000016.10:g.68808525C>A	ClinVar
RCV000574597	p.Cys163Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808524G>C	ClinVar
rs748783182	p.Cys163Ser	missense variant	-	NC_000016.10:g.68808524G>C	ExAC,gnomAD
RCV000529493	p.Cys163Trp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808525C>G	ClinVar
RCV000228101	p.Cys163Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808524G>C	ClinVar
rs1064794230	p.Cys163Trp	missense variant	-	NC_000016.10:g.68808525C>G	-
RCV000554684	p.Asn166Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808534T>G	ClinVar
COSM5226736	p.Asn166MetPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808530A>-	NCI-TCGA Cosmic
rs1555515224	p.Asn166Lys	missense variant	-	NC_000016.10:g.68808534T>G	-
RCV000206273	p.Glu167Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808535G>A	ClinVar
COSM1659145	p.Glu167Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808535G>T	NCI-TCGA Cosmic
RCV000220446	p.Glu167Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808535G>A	ClinVar
RCV000590271	p.Glu167Lys	missense variant	-	NC_000016.10:g.68808535G>A	ClinVar
rs769076258	p.Glu167Lys	missense variant	-	NC_000016.10:g.68808535G>A	ExAC,TOPMed,gnomAD
RCV000639213	p.Lys168Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808539A>G	ClinVar
rs1483883033	p.Lys168Arg	missense variant	-	NC_000016.10:g.68808539A>G	-
RCV000204728	p.Gly169Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808540del	ClinVar
COSM5226337	p.Gly169ArgPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808535_68808536insA	NCI-TCGA Cosmic
NCI-TCGA novel	p.Gly169Cys	missense variant	-	NC_000016.10:g.68808541G>T	NCI-TCGA
rs1284865285	p.Pro170Ser	missense variant	-	NC_000016.10:g.68808544C>T	gnomAD
rs772622109	p.Phe171Cys	missense variant	-	NC_000016.10:g.68808548T>G	ExAC,TOPMed,gnomAD
RCV000579712	p.Phe171Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808548T>G	ClinVar
RCV000529730	p.Phe171Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808548T>G	ClinVar
RCV000480184	p.Phe171Cys	missense variant	-	NC_000016.10:g.68808548T>G	ClinVar
rs762388314	p.Phe171Ile	missense variant	-	NC_000016.10:g.68808547T>A	ExAC,gnomAD
RCV000479605	p.Asn174Ter	frameshift	-	NC_000016.10:g.68808557dup	ClinVar
RCV000128977	p.Asn174Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808557dup	ClinVar
rs571581856	p.Asn174Lys	missense variant	-	NC_000016.10:g.68808558C>A	1000Genomes,ExAC,TOPMed,gnomAD
RCV000469682	p.Asn174Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808558C>A	ClinVar
RCV000484145	p.Asn174Lys	missense variant	-	NC_000016.10:g.68808558C>A	ClinVar
RCV000571602	p.Asn174Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808558C>A	ClinVar
NCI-TCGA novel	p.Asn174ThrPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68808553A>-	NCI-TCGA
COSM4062175	p.Leu175Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68808560T>C	NCI-TCGA Cosmic
RCV000569995	p.Gln177Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808565C>T	ClinVar
rs1555515232	p.Gln177Ter	stop gained	-	NC_000016.10:g.68808565C>T	-
RCV000736292	p.Lys179Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808696A>G	ClinVar
RCV000588871	p.Lys179Glu	missense variant	-	NC_000016.10:g.68808696A>G	ClinVar
rs1376749029	p.Lys179Thr	missense variant	-	NC_000016.10:g.68808697A>C	TOPMed
rs1555515244	p.Lys179Glu	missense variant	-	NC_000016.10:g.68808696A>G	-
COSM5833141	p.Asn181ThrPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808700C>-	NCI-TCGA Cosmic
NCI-TCGA novel	p.Asn181Thr	missense variant	-	NC_000016.10:g.68808703A>C	NCI-TCGA
RCV000485548	p.Lys182Asn	missense variant	-	NC_000016.10:g.68808707A>C	ClinVar
RCV000584034	p.Lys182Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808705A>G	ClinVar
RCV000537889	p.Lys182Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808707A>C	ClinVar
rs1555515245	p.Lys182Glu	missense variant	-	NC_000016.10:g.68808705A>G	-
rs201141645	p.Lys182Asn	missense variant	-	NC_000016.10:g.68808707A>C	1000Genomes,ExAC,TOPMed,gnomAD
rs759668091	p.Asp183Asn	missense variant	-	NC_000016.10:g.68808708G>A	ExAC,gnomAD
RCV000814393	p.Lys184Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808713A>C	ClinVar
rs200796553	p.Lys184Ile	missense variant	-	NC_000016.10:g.68808712A>T	1000Genomes
RCV000561775	p.Lys184Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808713A>C	ClinVar
rs1555515248	p.Lys184Asn	missense variant	-	NC_000016.10:g.68808713A>C	-
rs1060501228	p.Glu185Val	missense variant	-	NC_000016.10:g.68808715A>T	-
rs1434277339	p.Glu185Gln	missense variant	-	NC_000016.10:g.68808714G>C	TOPMed
RCV000460766	p.Glu185Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808715A>T	ClinVar
RCV000693136	p.Gly186Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808718G>T	ClinVar
COSM4935145	p.Lys187Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68808721A>G	NCI-TCGA Cosmic
RCV000561683	p.Val188Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808723G>A	ClinVar
COSM4062176	p.Val188Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68808724T>A	NCI-TCGA Cosmic
RCV000219361	p.Val188Ile	missense variant	-	NC_000016.10:g.68808723G>A	ClinVar
rs775484115	p.Val188Ile	missense variant	-	NC_000016.10:g.68808723G>A	ExAC,gnomAD
NCI-TCGA novel	p.Val188Phe	missense variant	-	NC_000016.10:g.68808723G>T	NCI-TCGA
COSM4062177	p.Tyr190Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68808730A>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Tyr190LeuPheSerTerUnk	frameshift	-	NC_000016.10:g.68808728_68808729insT	NCI-TCGA
RCV000679578	p.Ile192Val	missense variant	-	NC_000016.10:g.68808735A>G	ClinVar
RCV000130285	p.Ile192Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808735A>G	ClinVar
RCV000639219	p.Ile192Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808735A>G	ClinVar
rs376102028	p.Ile192Val	missense variant	-	NC_000016.10:g.68808735A>G	ESP,ExAC,gnomAD
VAR_001307	p.Thr193Pro	Missense	-	-	UniProt
COSM3818342	p.Gln195Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808744C>T	NCI-TCGA Cosmic
RCV000567664	p.Gln195His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808746A>C	ClinVar
rs1555515262	p.Gln195His	missense variant	-	NC_000016.10:g.68808746A>C	-
NCI-TCGA novel	p.Ala197Thr	missense variant	-	NC_000016.10:g.68808750G>A	NCI-TCGA
rs1308439785	p.Asp198Asn	missense variant	-	NC_000016.10:g.68808753G>A	gnomAD
RCV000562959	p.Asp198His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808753G>C	ClinVar
RCV000581132	p.Asp198Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808753G>A	ClinVar
rs1308439785	p.Asp198His	missense variant	-	NC_000016.10:g.68808753G>C	gnomAD
rs750249747	p.Thr199Ile	missense variant	-	NC_000016.10:g.68808757C>T	ExAC,gnomAD
RCV000566758	p.Thr199Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808757C>A	ClinVar
RCV000560934	p.Thr199Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808755_68808756insT	ClinVar
rs876658424	p.Thr199Ser	missense variant	-	NC_000016.10:g.68808756A>T	TOPMed,gnomAD
rs750249747	p.Thr199Lys	missense variant	-	NC_000016.10:g.68808757C>A	ExAC,gnomAD
RCV000462620	p.Thr199Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808756A>T	ClinVar
RCV000223207	p.Thr199Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808756A>T	ClinVar
RCV000543706	p.Pro200Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808760C>T	ClinVar
rs1555515266	p.Pro200Leu	missense variant	-	NC_000016.10:g.68808760C>T	-
RCV000809357	p.Pro201His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808763C>A	ClinVar
rs146777134	p.Pro201His	missense variant	-	NC_000016.10:g.68808763C>A	ESP,ExAC,TOPMed,gnomAD
COSM3818344	p.Pro201Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68808762C>G	NCI-TCGA Cosmic
COSM5833142	p.Pro201LeuPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808759C>-	NCI-TCGA Cosmic
COSM3888814	p.Pro201Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68808762C>T	NCI-TCGA Cosmic
RCV000484451	p.Pro201Arg	missense variant	-	NC_000016.10:g.68808763C>G	ClinVar
RCV000571741	p.Pro201Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808763C>G	ClinVar
RCV000574170	p.Pro201His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808763C>A	ClinVar
RCV000639285	p.Pro201Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808763C>G	ClinVar
rs146777134	p.Pro201Arg	missense variant	-	NC_000016.10:g.68808763C>G	ESP,ExAC,TOPMed,gnomAD
RCV000505993	p.Val202Leu	missense variant	-	NC_000016.10:g.68808765G>C	ClinVar
RCV000216760	p.Val202Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808765G>C	ClinVar
rs546716073	p.Val202Leu	missense variant	-	NC_000016.10:g.68808765G>C	1000Genomes,ExAC,TOPMed,gnomAD
COSM5205432	p.Val202CysPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808758_68808759insC	NCI-TCGA Cosmic
RCV000522621	p.Val202Ter	frameshift	-	NC_000016.10:g.68808764del	ClinVar
RCV000120512	p.Val202Ile	missense variant	-	NC_000016.10:g.68808765G>A	ClinVar
rs546716073	p.Val202Ile	missense variant	-	NC_000016.10:g.68808765G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1257844218	p.Val202Ala	missense variant	-	NC_000016.10:g.68808766T>C	TOPMed
RCV000492348	p.Val202Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808764del	ClinVar
NCI-TCGA novel	p.Val202LeuPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68808758_68808759insCC	NCI-TCGA
RCV000695606	p.Gly203Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808768G>A	ClinVar
rs1215319435	p.Gly203Ser	missense variant	-	NC_000016.10:g.68808768G>A	gnomAD
rs753584564	p.Gly203Asp	missense variant	-	NC_000016.10:g.68808769G>A	ExAC,gnomAD
rs1215319435	p.Gly203Arg	missense variant	-	NC_000016.10:g.68808768G>C	gnomAD
RCV000773351	p.Gly203Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808768G>C	ClinVar
RCV000698915	p.Val204Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808771G>A	ClinVar
RCV000221294	p.Val204Ile	missense variant	-	NC_000016.10:g.68808771G>A	ClinVar
rs754581268	p.Val204Ala	missense variant	-	NC_000016.10:g.68808772T>C	ExAC,gnomAD
rs876661028	p.Val204Ile	missense variant	-	NC_000016.10:g.68808771G>A	-
RCV000736289	p.Phe205Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808775T>C	ClinVar
NCI-TCGA novel	p.Phe205LeuPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68808774T>-	NCI-TCGA
rs1004655282	p.Ile206Leu	missense variant	-	NC_000016.10:g.68808777A>C	TOPMed
COSM5833143	p.Ile206TyrPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808773_68808774insT	NCI-TCGA Cosmic
RCV000590684	p.Ile206Val	missense variant	-	NC_000016.10:g.68808777A>G	ClinVar
rs1254143781	p.Ile206Thr	missense variant	-	NC_000016.10:g.68808778T>C	gnomAD
rs1004655282	p.Ile206Val	missense variant	-	NC_000016.10:g.68808777A>G	TOPMed
RCV000774764	p.Ile207Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808781T>C	ClinVar
rs778570149	p.Ile207Thr	missense variant	-	NC_000016.10:g.68808781T>C	ExAC,TOPMed,gnomAD
rs1470258333	p.Ile207Val	missense variant	-	NC_000016.10:g.68808780A>G	gnomAD
RCV000568330	p.Glu208Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808783G>A	ClinVar
rs898610512	p.Glu208Lys	missense variant	-	NC_000016.10:g.68808783G>A	TOPMed
rs1060501243	p.Arg209Lys	missense variant	-	NC_000016.10:g.68808787G>A	-
RCV000468759	p.Arg209Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808787G>A	ClinVar
NCI-TCGA novel	p.Arg209GluPheSerTerUnk	frameshift	-	NC_000016.10:g.68808784A>-	NCI-TCGA
COSM3421114	p.Glu210Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68808789G>T	NCI-TCGA Cosmic
RCV000129994	p.Thr211Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808792A>T	ClinVar
rs587781766	p.Thr211Ser	missense variant	-	NC_000016.10:g.68808792A>T	TOPMed
rs587781766	p.Thr211Ala	missense variant	-	NC_000016.10:g.68808792A>G	TOPMed
RCV000487179	p.Gly212Arg	missense variant	-	NC_000016.10:g.68808795G>A	ClinVar
RCV000562055	p.Gly212Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808796G>T	ClinVar
rs1555515276	p.Gly212Val	missense variant	-	NC_000016.10:g.68808796G>T	-
COSM2996751	p.Gly212Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68808796G>A	NCI-TCGA Cosmic
RCV000736283	p.Gly212Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808796G>T	ClinVar
rs1064796210	p.Gly212Arg	missense variant	-	NC_000016.10:g.68808795G>A	-
RCV000575669	p.Trp213Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808798T>A	ClinVar
RCV000687455	p.Trp213Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808799G>T	ClinVar
rs1555515277	p.Trp213Arg	missense variant	-	NC_000016.10:g.68808798T>A	-
RCV000130391	p.Val216Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808807G>A	ClinVar
rs587781989	p.Val216Met	missense variant	-	NC_000016.10:g.68808807G>A	-
RCV000569411	p.Thr217Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808811C>A	ClinVar
RCV000703043	p.Thr217Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808810A>G	ClinVar
rs778382252	p.Thr217Ile	missense variant	-	NC_000016.10:g.68808811C>T	ExAC,TOPMed,gnomAD
RCV000205264	p.Thr217Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808811C>A	ClinVar
RCV000216872	p.Thr217Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808811C>T	ClinVar
rs778382252	p.Thr217Lys	missense variant	-	NC_000016.10:g.68808811C>A	ExAC,TOPMed,gnomAD
RCV000481519	p.Glu218Gly	missense variant	-	NC_000016.10:g.68808814A>G	ClinVar
RCV000228318	p.Glu218Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808814A>G	ClinVar
RCV000563958	p.Glu218Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808813G>A	ClinVar
RCV000558519	p.Glu218Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808813G>A	ClinVar
rs1555515280	p.Glu218Lys	missense variant	-	NC_000016.10:g.68808813G>A	-
rs878854693	p.Glu218Gly	missense variant	-	NC_000016.10:g.68808814A>G	-
NCI-TCGA novel	p.Glu218Ter	stop gained	-	NC_000016.10:g.68808813G>T	NCI-TCGA
RCV000578321	p.Pro219Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808817del	ClinVar
RCV000759015	p.Pro219Ter	frameshift	-	NC_000016.10:g.68808817del	ClinVar
rs1060501216	p.Pro219Ser	missense variant	-	NC_000016.10:g.68808816C>T	-
RCV000461511	p.Pro219Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808816C>T	ClinVar
RCV000470596	p.Leu220Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808819C>A	ClinVar
rs1060501246	p.Leu220Met	missense variant	-	NC_000016.10:g.68808819C>A	-
NCI-TCGA novel	p.Leu220His	inframe deletion	-	NC_000016.10:g.68808820_68808822TGG>-	NCI-TCGA
COSM1324346	p.Asp221Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68808823A>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Asp221Ala	missense variant	-	NC_000016.10:g.68808823A>C	NCI-TCGA
NCI-TCGA novel	p.Asp221Glu	missense variant	-	NC_000016.10:g.68808824T>A	NCI-TCGA
rs1555515287	p.Arg222Lys	missense variant	-	NC_000016.10:g.68808826G>A	-
COSM4062178	p.Arg222Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68808825A>G	NCI-TCGA Cosmic
RCV000536984	p.Arg222Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808826G>A	ClinVar
rs200310662	p.Arg224Ser	missense variant	-	NC_000016.10:g.68808831C>A	ESP,ExAC,TOPMed,gnomAD
RCV000131242	p.Arg224Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808831C>A	ClinVar
RCV000212353	p.Arg224Cys	missense variant	-	NC_000016.10:g.68808831C>T	ClinVar
RCV000781206	p.Arg224Leu	missense variant	-	NC_000016.10:g.68808832G>T	ClinVar
RCV000129943	p.Arg224His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808832G>A	ClinVar
rs201511530	p.Arg224Leu	missense variant	-	NC_000016.10:g.68808832G>T	ExAC,TOPMed,gnomAD
rs201511530	p.Arg224His	missense variant	-	NC_000016.10:g.68808832G>A	ExAC,TOPMed,gnomAD
rs200310662	p.Arg224Cys	missense variant	-	NC_000016.10:g.68808831C>T	ESP,ExAC,TOPMed,gnomAD
RCV000168059	p.Ile225Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808835T>C	ClinVar
RCV000166415	p.Ile225Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808835T>C	ClinVar
RCV000579503	p.Ile225Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808834A>T	ClinVar
rs786203207	p.Ile225Thr	missense variant	-	NC_000016.10:g.68808835T>C	gnomAD
rs1555515290	p.Ile225Phe	missense variant	-	NC_000016.10:g.68808834A>T	-
RCV000534929	p.Ala226Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68808838C>T	ClinVar
rs1555515292	p.Ala226Val	missense variant	-	NC_000016.10:g.68808838C>T	-
RCV000564114	p.Thr227Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68808840A>G	ClinVar
RCV000483491	p.Thr227Ala	missense variant	-	NC_000016.10:g.68808840A>G	ClinVar
rs1064796018	p.Thr227Ala	missense variant	-	NC_000016.10:g.68808840A>G	gnomAD
rs1354439750	p.Thr229Ile	missense variant	-	NC_000016.10:g.68808847C>T	TOPMed
RCV000574198	p.Ser232Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810204C>G	ClinVar
rs1555515422	p.Ser232Cys	missense variant	-	NC_000016.10:g.68810204C>G	-
RCV000466995	p.His233Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810201_68810202TC[2]	ClinVar
RCV000217590	p.His233Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810208C>G	ClinVar
rs1352098199	p.His233Tyr	missense variant	-	NC_000016.10:g.68810206C>T	gnomAD
rs115494727	p.His233Gln	missense variant	-	NC_000016.10:g.68810208C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs1377039383	p.Ala234Val	missense variant	-	NC_000016.10:g.68810210C>T	TOPMed
rs878854694	p.Ala234Thr	missense variant	-	NC_000016.10:g.68810209G>A	-
RCV000232292	p.Ala234Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810209G>A	ClinVar
RCV000160385	p.Ser236Ter	nonsense	-	NC_000016.10:g.68810216C>A	ClinVar
rs730881663	p.Ser236Ter	stop gained	-	NC_000016.10:g.68810216C>A	-
RCV000561727	p.Asn238His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810221A>C	ClinVar
rs730881664	p.Asn238His	missense variant	-	NC_000016.10:g.68810221A>C	ExAC,TOPMed,gnomAD
RCV000528259	p.Asn238His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810221A>C	ClinVar
RCV000160386	p.Asn238His	missense variant	-	NC_000016.10:g.68810221A>C	ClinVar
NCI-TCGA novel	p.Asn238Ter	frameshift	-	NC_000016.10:g.68810220_68810221insT	NCI-TCGA
NCI-TCGA novel	p.Asn238Ter	frameshift	-	NC_000016.10:g.68810221_68810234AACGGGAATGCAGT>-	NCI-TCGA
RCV000119150	p.Gly239Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810224G>A	ClinVar
rs587780537	p.Gly239Arg	missense variant	-	NC_000016.10:g.68810224G>A	-
RCV000486588	p.Asn240Ser	missense variant	-	NC_000016.10:g.68810228A>G	ClinVar
RCV000575157	p.Asn240Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810228A>G	ClinVar
rs587780788	p.Asn240Ser	missense variant	-	NC_000016.10:g.68810228A>G	-
RCV000663083	p.Asn240Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810229del	ClinVar
RCV000767163	p.Asn240Ser	missense variant	-	NC_000016.10:g.68810228A>G	ClinVar
RCV000123254	p.Asn240Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810228A>G	ClinVar
RCV000492558	p.Asn240Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810229del	ClinVar
RCV000561381	p.Ala241Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810230G>A	ClinVar
rs1555515434	p.Ala241Thr	missense variant	-	NC_000016.10:g.68810230G>A	-
rs1267605366	p.Ala241Gly	missense variant	-	NC_000016.10:g.68810231C>G	TOPMed
rs111662525	p.Val242Leu	missense variant	-	NC_000016.10:g.68810233G>C	TOPMed,gnomAD
RCV000480312	p.Val242Ile	missense variant	-	NC_000016.10:g.68810233G>A	ClinVar
RCV000479743	p.Val242Leu	missense variant	-	NC_000016.10:g.68810233G>C	ClinVar
rs111662525	p.Val242Ile	missense variant	-	NC_000016.10:g.68810233G>A	TOPMed,gnomAD
RCV000204783	p.Val242Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810233G>A	ClinVar
COSM1302175	p.Glu243Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68810236G>C	NCI-TCGA Cosmic
COSM435592	p.Glu243Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68810236G>A	NCI-TCGA Cosmic
rs1064794231	p.Asp244Gly	missense variant	-	NC_000016.10:g.68810240A>G	TOPMed
rs1064794231	p.Asp244Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810240A>G	UniProt,dbSNP
VAR_008712	p.Asp244Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810240A>G	UniProt
RCV000486442	p.Asp244Gly	missense variant	-	NC_000016.10:g.68810240A>G	ClinVar
RCV000568819	p.Asp244Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810240A>G	ClinVar
RCV000698453	p.Asp244Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810240A>G	ClinVar
rs371612417	p.Pro245Leu	missense variant	-	NC_000016.10:g.68810243C>T	ESP,ExAC,gnomAD
RCV000582967	p.Glu247Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810248G>A	ClinVar
RCV000773508	p.Glu247Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810249A>G	ClinVar
rs1555515437	p.Glu247Lys	missense variant	-	NC_000016.10:g.68810248G>A	-
NCI-TCGA novel	p.Glu247AspPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68810244_68810245insATGG	NCI-TCGA
COSM4062179	p.Ile248Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68810251A>T	NCI-TCGA Cosmic
RCV000553471	p.Ile248Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810252T>C	ClinVar
rs1555515438	p.Ile248Thr	missense variant	-	NC_000016.10:g.68810252T>C	-
COSM3782980	p.Leu249Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68810254T>G	NCI-TCGA Cosmic
COSM3818345	p.Thr251Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68810261C>A	NCI-TCGA Cosmic
rs1454205778	p.Thr251Met	missense variant	-	NC_000016.10:g.68810261C>T	gnomAD
RCV000574325	p.Val252Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810263G>A	ClinVar
rs1358319984	p.Val252Ile	missense variant	-	NC_000016.10:g.68810263G>A	TOPMed,gnomAD
RCV000701764	p.Val252Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810263G>A	ClinVar
RCV000572481	p.Thr253Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810267C>T	ClinVar
rs776503962	p.Thr253Ile	missense variant	-	NC_000016.10:g.68810267C>T	ExAC,gnomAD
RCV000736291	p.Asp254His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810269G>C	ClinVar
RCV000505743	p.Asp254Tyr	missense variant	Ectropion inferior cleft lip and or palate (BCDS1)	NC_000016.10:g.68810269G>T	ClinVar
rs1555515445	p.Asp254Tyr	missense variant	-	NC_000016.10:g.68810269G>T	-
rs1555515445	p.Asp254Tyr	missense variant	Blepharocheilodontic syndrome 1 (BCDS1)	NC_000016.10:g.68810269G>T	UniProt,dbSNP
VAR_079392	p.Asp254Tyr	missense variant	Blepharocheilodontic syndrome 1 (BCDS1)	NC_000016.10:g.68810269G>T	UniProt
COSM19780	p.Gln255Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68810272C>T	NCI-TCGA Cosmic
RCV000639203	p.Asp257Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810279A>G	ClinVar
rs1555515446	p.Asp257Gly	missense variant	-	NC_000016.10:g.68810279A>G	-
COSM1379150	p.Asp257Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68810278G>A	NCI-TCGA Cosmic
VAR_079393	p.Asp257Val	Missense	Blepharocheilodontic syndrome 1 (BCDS1) [MIM:119580]	-	UniProt
RCV000538702	p.Asn258Tyr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810281A>T	ClinVar
rs1555515449	p.Asn258Tyr	missense variant	-	NC_000016.10:g.68810281A>T	-
COSM435593	p.Pro260His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68810288C>A	NCI-TCGA Cosmic
RCV000709394	p.Pro260Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810287C>T	ClinVar
RCV000013021	p.Glu261Ter	nonsense	Breast cancer, lobular (LBC)	NC_000016.10:g.68810290G>T	ClinVar
RCV000480274	p.Glu261Lys	missense variant	-	NC_000016.10:g.68810290G>A	ClinVar
RCV000475944	p.Glu261Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810290G>A	ClinVar
rs121964873	p.Glu261Ter	stop gained	-	NC_000016.10:g.68810290G>T	ExAC,gnomAD
rs121964873	p.Glu261Lys	missense variant	-	NC_000016.10:g.68810290G>A	ExAC,gnomAD
RCV000700966	p.Phe262Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810293T>G	ClinVar
RCV000571849	p.Thr263Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810296A>T	ClinVar
RCV000531759	p.Thr263Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810297C>T	ClinVar
rs1555515453	p.Thr263Ser	missense variant	-	NC_000016.10:g.68810296A>T	-
RCV000584658	p.Thr263Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810297C>G	ClinVar
rs1555515456	p.Thr263Ser	missense variant	-	NC_000016.10:g.68810297C>G	-
rs1555515456	p.Thr263Ile	missense variant	-	NC_000016.10:g.68810297C>T	-
NCI-TCGA novel	p.Gln264His	missense variant	-	NC_000016.10:g.68810301G>T	NCI-TCGA
RCV000457462	p.Glu265Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810302G>T	ClinVar
RCV000465251	p.Glu265Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810302G>C	ClinVar
RCV000217330	p.Glu265Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810302G>C	ClinVar
RCV000230097	p.Glu265Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810303A>T	ClinVar
RCV000132223	p.Glu265Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810303A>T	ClinVar
RCV000483098	p.Glu265Gln	missense variant	-	NC_000016.10:g.68810302G>C	ClinVar
rs587782728	p.Glu265Val	missense variant	-	NC_000016.10:g.68810303A>T	TOPMed,gnomAD
rs876659503	p.Glu265Lys	missense variant	-	NC_000016.10:g.68810302G>A	TOPMed,gnomAD
rs876659503	p.Glu265Gln	missense variant	-	NC_000016.10:g.68810302G>C	TOPMed,gnomAD
RCV000561464	p.Glu265Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810302G>A	ClinVar
RCV000212356	p.Glu265Val	missense variant	-	NC_000016.10:g.68810303A>T	ClinVar
rs876659503	p.Glu265Ter	stop gained	-	NC_000016.10:g.68810302G>T	TOPMed,gnomAD
RCV000698427	p.Val266Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810305G>T	ClinVar
RCV000566247	p.Val266Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810305G>T	ClinVar
rs1555515463	p.Val266Phe	missense variant	-	NC_000016.10:g.68810305G>T	-
RCV000507564	p.Gly269Arg	missense variant	-	NC_000016.10:g.68810314G>A	ClinVar
rs750979600	p.Gly269Arg	missense variant	-	NC_000016.10:g.68810314G>A	ExAC,gnomAD
RCV000580394	p.Gly269Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810314G>A	ClinVar
RCV000235151	p.Ser270Ala	missense variant	-	NC_000016.10:g.68810317T>G	ClinVar
rs587776399	p.Ser270Ala	missense variant	-	NC_000016.10:g.68810317T>G	ExAC,TOPMed,gnomAD
RCV000774980	p.Met272Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810324T>C	ClinVar
NCI-TCGA novel	p.Met272LeuPheSerTerUnk	frameshift	-	NC_000016.10:g.68810320_68810329GTCATGGAAG>-	NCI-TCGA
RCV000586470	p.Glu273Val	missense variant	-	NC_000016.10:g.68810327A>T	ClinVar
rs1555515467	p.Glu273Val	missense variant	-	NC_000016.10:g.68810327A>T	-
RCV000639216	p.Gly274Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810329G>A	ClinVar
rs876660861	p.Gly274Val	missense variant	-	NC_000016.10:g.68810330G>T	-
rs781513008	p.Gly274Ser	missense variant	-	NC_000016.10:g.68810329G>A	ExAC,gnomAD
RCV000546498	p.Gly274Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810330G>T	ClinVar
rs876660861	p.Gly274Asp	missense variant	-	NC_000016.10:g.68810330G>A	-
RCV000220126	p.Gly274Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810330G>A	ClinVar
VAR_001308	p.Gly274_Pro277del	inframe_deletion	-	-	UniProt
RCV000459067	p.Leu276Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810335C>G	ClinVar
RCV000217001	p.Leu276Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68810335C>G	ClinVar
rs750911401	p.Leu276Val	missense variant	-	NC_000016.10:g.68810335C>G	ExAC,gnomAD
RCV000204369	p.Pro277Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68810338C>T	ClinVar
rs864622346	p.Pro277Ser	missense variant	-	NC_000016.10:g.68810338C>T	TOPMed
RCV000639201	p.Gly278Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811684G>A	ClinVar
COSM3818347	p.Gly278Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68810341G>T	NCI-TCGA Cosmic
rs1555515597	p.Gly278Glu	missense variant	-	NC_000016.10:g.68811684G>A	-
rs943875725	p.Gly278Arg	missense variant	-	NC_000016.10:g.68810341G>C	gnomAD
rs943875725	p.Gly278Arg	missense variant	-	NC_000016.10:g.68810341G>A	gnomAD
NCI-TCGA novel	p.Gly278Val	missense variant	-	NC_000016.10:g.68811684G>T	NCI-TCGA
rs761269950	p.Thr279Ser	missense variant	-	NC_000016.10:g.68811687C>G	ExAC,gnomAD
RCV000567156	p.Thr279Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811687C>G	ClinVar
rs761269950	p.Thr279Ile	missense variant	-	NC_000016.10:g.68811687C>T	ExAC,gnomAD
rs761269950	p.Thr279Asn	missense variant	-	NC_000016.10:g.68811687C>A	ExAC,gnomAD
RCV000559810	p.Met282Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811696T>C	ClinVar
RCV000572511	p.Met282Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811697G>A	ClinVar
rs730881652	p.Met282Thr	missense variant	-	NC_000016.10:g.68811696T>C	ExAC,TOPMed,gnomAD
rs200932258	p.Met282Ile	missense variant	-	NC_000016.10:g.68811697G>T	ExAC,TOPMed,gnomAD
RCV000221994	p.Met282Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811696T>C	ClinVar
RCV000160367	p.Met282Thr	missense variant	-	NC_000016.10:g.68811696T>C	ClinVar
RCV000204924	p.Met282Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811697G>A	ClinVar
RCV000478288	p.Met282Ile	missense variant	-	NC_000016.10:g.68811697G>A	ClinVar
rs200932258	p.Met282Ile	missense variant	-	NC_000016.10:g.68811697G>A	ExAC,TOPMed,gnomAD
rs200932258	p.Met282Ile	missense variant	-	NC_000016.10:g.68811697G>A	UniProt,dbSNP
VAR_033026	p.Met282Ile	missense variant	-	NC_000016.10:g.68811697G>A	UniProt
RCV000566414	p.Glu283Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811698G>A	ClinVar
rs1555515601	p.Glu283Lys	missense variant	-	NC_000016.10:g.68811698G>A	-
RCV000165133	p.Val284Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811701G>A	ClinVar
rs786202364	p.Val284Ile	missense variant	-	NC_000016.10:g.68811701G>A	-
RCV000534721	p.Thr285Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811705C>T	ClinVar
RCV000656819	p.Thr285Ile	missense variant	-	NC_000016.10:g.68811705C>T	ClinVar
RCV000261135	p.Thr285Ile	missense variant	-	NC_000016.10:g.68811705C>T	ClinVar
rs587781634	p.Thr285Ile	missense variant	-	NC_000016.10:g.68811705C>T	ExAC,TOPMed,gnomAD
RCV000129743	p.Thr285Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811705C>T	ClinVar
COSM5833144	p.Asp288GlyPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68811714_68811715AC>-	NCI-TCGA Cosmic
COSM3818348	p.Asp288Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68811713G>A	NCI-TCGA Cosmic
COSM4771810	p.Asp288Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68811714A>T	NCI-TCGA Cosmic
RCV000561485	p.Ala289Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811717C>T	ClinVar
RCV000759018	p.Ala289Thr	missense variant	-	NC_000016.10:g.68811716G>A	ClinVar
RCV000639266	p.Ala289Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811716G>A	ClinVar
rs780399325	p.Ala289Val	missense variant	-	NC_000016.10:g.68811717C>T	ExAC,gnomAD
RCV000777632	p.Ala289Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811716G>A	ClinVar
rs1255556757	p.Ala289Thr	missense variant	-	NC_000016.10:g.68811716G>A	gnomAD
RCV000196783	p.Ala289Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811717C>T	ClinVar
NCI-TCGA novel	p.Ala289ThrPheSerTerUnk	frameshift	-	NC_000016.10:g.68811713_68811714insAC	NCI-TCGA
COSM4062180	p.Asp290Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68811720A>G	NCI-TCGA Cosmic
RCV000481971	p.Asp291Tyr	missense variant	-	NC_000016.10:g.68811722G>T	ClinVar
RCV000222993	p.Asp291Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811722G>A	ClinVar
RCV000482281	p.Asp291Asn	missense variant	-	NC_000016.10:g.68811722G>A	ClinVar
COSM435595	p.Asp291MetPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68811722G>-	NCI-TCGA Cosmic
rs876660645	p.Asp291Asn	missense variant	-	NC_000016.10:g.68811722G>A	gnomAD
rs876660645	p.Asp291Tyr	missense variant	-	NC_000016.10:g.68811722G>T	gnomAD
RCV000694385	p.Asp291Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811722G>A	ClinVar
RCV000218369	p.Val293Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811729T>C	ClinVar
rs876659186	p.Val293Ala	missense variant	-	NC_000016.10:g.68811729T>C	-
NCI-TCGA novel	p.Asn294LysPheSerTerUnk	frameshift	-	NC_000016.10:g.68811716_68811717insCGGACGATGATGTGAAA	NCI-TCGA
RCV000581166	p.Thr295Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811734A>G	ClinVar
RCV000168224	p.Thr295Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811735C>A	ClinVar
RCV000703976	p.Thr295Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811734A>G	ClinVar
rs786204179	p.Thr295Asn	missense variant	-	NC_000016.10:g.68811735C>A	-
rs1555515611	p.Thr295Ala	missense variant	-	NC_000016.10:g.68811734A>G	-
rs572375953	p.Asn297Ser	missense variant	-	NC_000016.10:g.68811741A>G	1000Genomes,ExAC,gnomAD
RCV000148457	p.Ala298Thr	missense variant	Neoplasm of stomach	NC_000016.10:g.68811743G>A	ClinVar
RCV000414947	p.Ala298Thr	missense variant	-	NC_000016.10:g.68811743G>A	ClinVar
rs142822590	p.Ala298Thr	missense variant	-	NC_000016.10:g.68811743G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000231332	p.Ala299Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811747C>G	ClinVar
COSM4062181	p.Ala299Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68811746G>T	NCI-TCGA Cosmic
RCV000479514	p.Ala299Gly	missense variant	-	NC_000016.10:g.68811747C>G	ClinVar
RCV000580494	p.Ala299Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811747C>G	ClinVar
rs745807727	p.Ala299Gly	missense variant	-	NC_000016.10:g.68811747C>G	ExAC,gnomAD
NCI-TCGA novel	p.Ala299Thr	missense variant	-	NC_000016.10:g.68811746G>A	NCI-TCGA
rs1167723442	p.Ile300Val	missense variant	-	NC_000016.10:g.68811749A>G	gnomAD
RCV000164825	p.Ala301Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811752G>A	ClinVar
RCV000409432	p.Ala301Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811752G>A	ClinVar
rs749056300	p.Ala301Thr	missense variant	-	NC_000016.10:g.68811752G>A	ExAC,TOPMed,gnomAD
rs768467134	p.Tyr302Cys	missense variant	-	NC_000016.10:g.68811756A>G	ExAC,gnomAD
RCV000214986	p.Thr303Ala	missense variant	-	NC_000016.10:g.68811758A>G	ClinVar
RCV000639236	p.Thr303Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811758A>G	ClinVar
RCV000218776	p.Thr303Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811758A>T	ClinVar
rs876660744	p.Thr303Ser	missense variant	-	NC_000016.10:g.68811758A>T	gnomAD
rs876660744	p.Thr303Ala	missense variant	-	NC_000016.10:g.68811758A>G	gnomAD
COSM5833145	p.Ile304AsnPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68811760_68811761insA	NCI-TCGA Cosmic
NCI-TCGA novel	p.Leu305Ile	missense variant	-	NC_000016.10:g.68811764C>A	NCI-TCGA
RCV000571766	p.Ser306Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811767A>G	ClinVar
rs1555515624	p.Ser306Gly	missense variant	-	NC_000016.10:g.68811767A>G	-
NCI-TCGA novel	p.Ser306Asn	missense variant	-	NC_000016.10:g.68811768G>A	NCI-TCGA
RCV000474222	p.Gln307His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811772A>C	ClinVar
rs876660221	p.Gln307His	missense variant	-	NC_000016.10:g.68811772A>C	-
NCI-TCGA novel	p.Gln307HisPheSerTerUnk	frameshift	-	NC_000016.10:g.68811769_68811803CCAAGATCCTGAGCTCCCTGACAAAAATATGTTCA>-	NCI-TCGA
rs1339256204	p.Asp308Asn	missense variant	-	NC_000016.10:g.68811773G>A	gnomAD
RCV000693080	p.Asp308Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811774A>T	ClinVar
RCV000573591	p.Asp308His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811773G>C	ClinVar
rs1339256204	p.Asp308His	missense variant	-	NC_000016.10:g.68811773G>C	gnomAD
RCV000575534	p.Pro309Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811777C>T	ClinVar
rs529089668	p.Pro309Leu	missense variant	-	NC_000016.10:g.68811777C>T	gnomAD
rs1291900177	p.Glu310Gly	missense variant	-	NC_000016.10:g.68811780A>G	TOPMed,gnomAD
RCV000570844	p.Leu311Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811782C>T	ClinVar
rs767003567	p.Leu311Ile	missense variant	-	NC_000016.10:g.68811782C>A	ExAC,TOPMed,gnomAD
rs767003567	p.Leu311Phe	missense variant	-	NC_000016.10:g.68811782C>T	ExAC,TOPMed,gnomAD
COSM1302177	p.Asp313Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68811788G>A	NCI-TCGA Cosmic
rs993545618	p.Asp313Tyr	missense variant	-	NC_000016.10:g.68811788G>T	TOPMed
RCV000492072	p.Lys314Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811791A>T	ClinVar
rs1131690820	p.Lys314Ter	stop gained	-	NC_000016.10:g.68811791A>T	-
NCI-TCGA novel	p.Lys314HisPheSerTerUnk	frameshift	-	NC_000016.10:g.68811789_68811802ACAAAAATATGTTC>-	NCI-TCGA
COSM1379159	p.Asn315LysPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68811790_68811791insA	NCI-TCGA Cosmic
COSM5211861	p.Asn315IlePheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68811791A>-	NCI-TCGA Cosmic
COSM19485	p.Asn315Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68811795A>G	NCI-TCGA Cosmic
VAR_001309	p.Asn315Ser	Missense	-	-	UniProt
RCV000574966	p.Met316Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811797A>G	ClinVar
RCV000559588	p.Met316Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811797A>G	ClinVar
RCV000780100	p.Met316Val	missense variant	-	NC_000016.10:g.68811797A>G	ClinVar
rs761182866	p.Met316Val	missense variant	-	NC_000016.10:g.68811797A>G	ExAC,gnomAD
NCI-TCGA novel	p.Met316Ile	inframe deletion	-	NC_000016.10:g.68811798_68811800TGT>-	NCI-TCGA
RCV000709395	p.Phe317Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811800T>C	ClinVar
rs1555515643	p.Phe317Ile	missense variant	-	NC_000016.10:g.68811800T>A	-
RCV000579416	p.Phe317Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811800T>A	ClinVar
RCV000569529	p.Thr318Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811804C>T	ClinVar
rs1555515644	p.Thr318Ile	missense variant	-	NC_000016.10:g.68811804C>T	-
RCV000576024	p.Ile319Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811806A>C	ClinVar
RCV000537891	p.Ile319Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811806A>C	ClinVar
rs1486730461	p.Ile319Val	missense variant	-	NC_000016.10:g.68811806A>G	gnomAD
RCV000639278	p.Ile319Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811806A>G	ClinVar
rs1486730461	p.Ile319Leu	missense variant	-	NC_000016.10:g.68811806A>C	gnomAD
rs1262816479	p.Asn320Ser	missense variant	-	NC_000016.10:g.68811810A>G	TOPMed,gnomAD
RCV000506969	p.Arg321Ser	missense variant	-	NC_000016.10:g.68811814G>C	ClinVar
RCV000582701	p.Arg321Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811812A>G	ClinVar
RCV000477423	p.Arg321Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811814G>C	ClinVar
rs1060501231	p.Arg321Ser	missense variant	-	NC_000016.10:g.68811814G>C	gnomAD
rs1555515649	p.Arg321Gly	missense variant	-	NC_000016.10:g.68811812A>G	-
RCV000806882	p.Asn322Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811816A>G	ClinVar
RCV000219110	p.Asn322Ser	missense variant	-	NC_000016.10:g.68811816A>G	ClinVar
rs876661274	p.Asn322Ser	missense variant	-	NC_000016.10:g.68811816A>G	-
rs1487750656	p.Thr323Arg	missense variant	-	NC_000016.10:g.68811819C>G	gnomAD
RCV000467135	p.Gly324Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811822G>A	ClinVar
rs1060501232	p.Gly324Ala	missense variant	-	NC_000016.10:g.68811822G>C	-
RCV000470334	p.Gly324Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811822G>C	ClinVar
rs1060501232	p.Gly324Glu	missense variant	-	NC_000016.10:g.68811822G>A	-
NCI-TCGA novel	p.Gly324Ter	stop gained	-	NC_000016.10:g.68811821G>T	NCI-TCGA
RCV000709396	p.Ile326Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811827A>G	ClinVar
rs1190209160	p.Ile326Thr	missense variant	-	NC_000016.10:g.68811828T>C	gnomAD
RCV000548107	p.Ser327Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811831G>C	ClinVar
RCV000698135	p.Ser327Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811832T>G	ClinVar
RCV000776380	p.Ser327Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811831G>C	ClinVar
RCV000130021	p.Ser327Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811831G>T	ClinVar
rs587781778	p.Ser327Thr	missense variant	-	NC_000016.10:g.68811831G>C	-
rs587781778	p.Ser327Ile	missense variant	-	NC_000016.10:g.68811831G>T	-
RCV000166059	p.Val328Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811833G>A	ClinVar
rs754228872	p.Val328Met	missense variant	-	NC_000016.10:g.68811833G>A	ExAC,gnomAD
RCV000686762	p.Val328Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811833G>A	ClinVar
RCV000478474	p.Val328Met	missense variant	-	NC_000016.10:g.68811833G>A	ClinVar
RCV000480528	p.Thr330Ile	missense variant	-	NC_000016.10:g.68811840C>T	ClinVar
RCV000580219	p.Thr330Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811840C>T	ClinVar
rs755371143	p.Thr330Ile	missense variant	-	NC_000016.10:g.68811840C>T	ExAC,gnomAD
NCI-TCGA novel	p.Thr331Ala	missense variant	-	NC_000016.10:g.68811842A>G	NCI-TCGA
RCV000129978	p.Gly332Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811845G>A	ClinVar
rs587781759	p.Gly332Arg	missense variant	-	NC_000016.10:g.68811845G>A	ExAC,gnomAD
rs752916727	p.Leu333Gln	missense variant	-	NC_000016.10:g.68811849T>A	ExAC,gnomAD
rs761981219	p.Asp334Glu	missense variant	-	NC_000016.10:g.68811853C>G	TOPMed,gnomAD
RCV000115832	p.Arg335Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811855G>A	ClinVar
RCV000586292	p.Arg335Gln	missense variant	-	NC_000016.10:g.68811855G>A	ClinVar
RCV000130670	p.Arg335Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811854C>T	ClinVar
RCV000218355	p.Arg335Ter	nonsense	-	NC_000016.10:g.68811854C>T	ClinVar
rs587780784	p.Arg335Ter	stop gained	-	NC_000016.10:g.68811854C>T	ExAC,TOPMed,gnomAD
RCV000229894	p.Arg335Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811855G>A	ClinVar
RCV000123230	p.Arg335Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68811854C>T	ClinVar
rs373364873	p.Arg335Gln	missense variant	-	NC_000016.10:g.68811855G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs587780784	p.Arg335Gly	missense variant	-	NC_000016.10:g.68811854C>G	ExAC,TOPMed,gnomAD
COSM4062182	p.Glu336Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68811857G>A	NCI-TCGA Cosmic
RCV000572541	p.Glu336Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68811859G>T	ClinVar
NCI-TCGA novel	p.Ser337ArgPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68811854_68811855insGAGA	NCI-TCGA
rs1060501219	p.Phe338Cys	missense variant	-	NC_000016.10:g.68812139T>G	gnomAD
rs1060501219	p.Phe338Ser	missense variant	-	NC_000016.10:g.68812139T>C	gnomAD
RCV000458147	p.Phe338Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812139T>G	ClinVar
RCV000639228	p.Pro339Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812141C>G	ClinVar
RCV000573380	p.Pro339Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812141C>G	ClinVar
COSM435597	p.Pro339LeuPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68812140C>-	NCI-TCGA Cosmic
rs1555515709	p.Pro339Ala	missense variant	-	NC_000016.10:g.68812141C>G	-
RCV000478241	p.Thr340Ser	missense variant	-	NC_000016.10:g.68812144A>T	ClinVar
RCV000529350	p.Thr340Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812144A>T	ClinVar
RCV000129966	p.Thr340Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812145C>T	ClinVar
RCV000677871	p.Thr340Ala	missense variant	Adenocarcinoma of stomach	NC_000016.10:g.68812144A>G	ClinVar
rs116093741	p.Thr340Ala	missense variant	-	NC_000016.10:g.68812144A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs116093741	p.Thr340Ser	missense variant	-	NC_000016.10:g.68812144A>T	1000Genomes,ExAC,TOPMed,gnomAD
rs61747631	p.Thr340Met	missense variant	-	NC_000016.10:g.68812145C>T	ESP,ExAC,TOPMed,gnomAD
rs587776398	p.Tyr341Ter	stop gained	-	NC_000016.10:g.68812149T>G	ExAC,gnomAD
COSM5833146	p.Tyr341ValPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68812145_68812146insG	NCI-TCGA Cosmic
RCV000144456	p.Tyr341Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812149T>G	ClinVar
NCI-TCGA novel	p.Tyr341Asp	missense variant	-	NC_000016.10:g.68812147T>G	NCI-TCGA
RCV000130563	p.Thr342Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812150A>T	ClinVar
rs587782073	p.Thr342Ser	missense variant	-	NC_000016.10:g.68812150A>T	TOPMed
RCV000639270	p.Thr342Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812150A>T	ClinVar
RCV000544122	p.Leu343Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812153C>G	ClinVar
rs1555515720	p.Leu343Val	missense variant	-	NC_000016.10:g.68812153C>G	-
NCI-TCGA novel	p.Val344Met	missense variant	-	NC_000016.10:g.68812156G>A	NCI-TCGA
RCV000574360	p.Val345Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812159G>A	ClinVar
RCV000805145	p.Val345Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812160T>C	ClinVar
RCV000523842	p.Val345Ter	frameshift	-	NC_000016.10:g.68812157_68812158dup	ClinVar
rs1064793080	p.Val345Ala	missense variant	-	NC_000016.10:g.68812160T>C	-
rs764532067	p.Val345Ile	missense variant	-	NC_000016.10:g.68812159G>A	ExAC,gnomAD
RCV000481386	p.Val345Ala	missense variant	-	NC_000016.10:g.68812160T>C	ClinVar
RCV000233415	p.Gln346Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812162C>G	ClinVar
rs1371443675	p.Gln346Arg	missense variant	-	NC_000016.10:g.68812163A>G	gnomAD
rs878854676	p.Gln346Glu	missense variant	-	NC_000016.10:g.68812162C>G	-
RCV000132493	p.Ala347Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812165G>A	ClinVar
rs587782869	p.Ala347Thr	missense variant	-	NC_000016.10:g.68812165G>A	ExAC,gnomAD
RCV000559014	p.Ala348Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812168G>T	ClinVar
rs1555515724	p.Ala348Ser	missense variant	-	NC_000016.10:g.68812168G>T	-
rs1273267349	p.Leu350Phe	missense variant	-	NC_000016.10:g.68812174C>T	gnomAD
rs1555515726	p.Gln351Ter	stop gained	-	NC_000016.10:g.68812177C>T	-
RCV000639274	p.Gln351Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812177C>T	ClinVar
rs762123073	p.Gln351Arg	missense variant	-	NC_000016.10:g.68812178A>G	ExAC,gnomAD
RCV000759719	p.Gly352Asp	missense variant	-	NC_000016.10:g.68812181G>A	ClinVar
rs1555515728	p.Gly352Asp	missense variant	-	NC_000016.10:g.68812181G>A	-
RCV000562131	p.Gly352Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812181G>A	ClinVar
NCI-TCGA novel	p.Gly352ArgPheSerTerUnk	frameshift	-	NC_000016.10:g.68812177_68812178insA	NCI-TCGA
RCV000216189	p.Glu353Lys	missense variant	-	NC_000016.10:g.68812183G>A	ClinVar
RCV000563121	p.Glu353Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812184A>T	ClinVar
rs1555515730	p.Glu353Val	missense variant	-	NC_000016.10:g.68812184A>T	-
RCV000196464	p.Gly354Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812190del	ClinVar
RCV000210107	p.Gly354Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812190del	ClinVar
rs1260033180	p.Thr357Ile	missense variant	-	NC_000016.10:g.68812196C>T	TOPMed,gnomAD
rs1260033180	p.Thr357Lys	missense variant	-	NC_000016.10:g.68812196C>A	TOPMed,gnomAD
RCV000564822	p.Thr358Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812199C>T	ClinVar
rs1191901557	p.Thr358Ile	missense variant	-	NC_000016.10:g.68812199C>T	TOPMed
rs549579183	p.Thr360Arg	missense variant	-	NC_000016.10:g.68812205C>G	1000Genomes,ExAC,gnomAD
rs1198506273	p.Val362Glu	missense variant	-	NC_000016.10:g.68812211T>A	gnomAD
RCV000563263	p.Val362Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812211del	ClinVar
RCV000736288	p.Val362Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812211del	ClinVar
rs1555515740	p.Ile363Leu	missense variant	-	NC_000016.10:g.68812213A>C	-
RCV000581894	p.Ile363Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812213A>C	ClinVar
RCV000215211	p.Thr364Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812217C>T	ClinVar
RCV000215755	p.Thr364Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812216A>T	ClinVar
RCV000458635	p.Thr364Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812217C>T	ClinVar
RCV000458391	p.Thr364Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812217C>G	ClinVar
RCV000461743	p.Thr364Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812216A>T	ClinVar
rs876658376	p.Thr364Ile	missense variant	-	NC_000016.10:g.68812217C>T	-
rs876658376	p.Thr364Arg	missense variant	-	NC_000016.10:g.68812217C>G	-
rs778868539	p.Thr364Ser	missense variant	-	NC_000016.10:g.68812216A>T	ExAC,gnomAD
NCI-TCGA novel	p.Thr364SerPheSerTerUnk	frameshift	-	NC_000016.10:g.68812215_68812216CA>-	NCI-TCGA
NCI-TCGA novel	p.Thr364HisPheSerTerUnk	frameshift	-	NC_000016.10:g.68812216_68812226ACAGTCACTGA>-	NCI-TCGA
RCV000579958	p.Val365Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812219G>A	ClinVar
rs1555515742	p.Val365Ile	missense variant	-	NC_000016.10:g.68812219G>A	-
NCI-TCGA novel	p.Val365ThrPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68812218_68812224AGTCACT>-	NCI-TCGA
RCV000639237	p.Thr366Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812223C>G	ClinVar
RCV000217212	p.Thr366Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812223C>G	ClinVar
RCV000456768	p.Thr366Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812222A>G	ClinVar
RCV000583142	p.Thr366Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812222A>G	ClinVar
rs1060501238	p.Thr366Ala	missense variant	-	NC_000016.10:g.68812222A>G	gnomAD
rs876660260	p.Thr366Ser	missense variant	-	NC_000016.10:g.68812223C>G	-
rs1060501238	p.Thr366Pro	missense variant	-	NC_000016.10:g.68812222A>C	gnomAD
RCV000227259	p.Thr368Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812229C>T	ClinVar
RCV000569346	p.Thr368Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812228A>G	ClinVar
rs367868307	p.Thr368Ser	missense variant	-	NC_000016.10:g.68812229C>G	ESP,ExAC,TOPMed,gnomAD
rs1555515749	p.Thr368Ala	missense variant	-	NC_000016.10:g.68812228A>G	-
RCV000776452	p.Thr368Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812229C>G	ClinVar
RCV000131921	p.Thr368Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812229C>T	ClinVar
RCV000775853	p.Thr368Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812228A>T	ClinVar
RCV000537671	p.Thr368Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812229C>G	ClinVar
RCV000759720	p.Thr368Ile	missense variant	-	NC_000016.10:g.68812229C>T	ClinVar
rs367868307	p.Thr368Ile	missense variant	-	NC_000016.10:g.68812229C>T	ESP,ExAC,TOPMed,gnomAD
RCV000702112	p.Asn369Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812233del	ClinVar
COSM1169611	p.Asp370Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68812235A>G	NCI-TCGA Cosmic
COSM4420757	p.Asp370Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68812234G>A	NCI-TCGA Cosmic
VAR_001311	p.Asp370Ala	Missense	-	-	UniProt
rs1555515754	p.Asn371Ser	missense variant	-	NC_000016.10:g.68812238A>G	-
RCV000564948	p.Asn371Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812238A>G	ClinVar
RCV000567625	p.Pro372Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812241C>T	ClinVar
RCV000566770	p.Pro372Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812240C>A	ClinVar
rs1555515760	p.Pro372Leu	missense variant	-	NC_000016.10:g.68812241C>T	-
rs1555515758	p.Pro372Thr	missense variant	-	NC_000016.10:g.68812240C>A	-
RCV000780090	p.Pro373Leu	missense variant	-	NC_000016.10:g.68812244C>T	ClinVar
RCV000231218	p.Pro373Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812244C>T	ClinVar
RCV000481162	p.Pro373Leu	missense variant	-	NC_000016.10:g.68812244C>T	ClinVar
RCV000478907	p.Pro373Arg	missense variant	-	NC_000016.10:g.68812244C>G	ClinVar
rs587782359	p.Pro373Arg	missense variant	-	NC_000016.10:g.68812244C>G	TOPMed,gnomAD
rs587782359	p.Pro373Leu	missense variant	-	NC_000016.10:g.68812244C>T	TOPMed,gnomAD
RCV000131314	p.Pro373Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812244C>T	ClinVar
rs1169866178	p.Asn376Ser	missense variant	-	NC_000016.10:g.68812253A>G	gnomAD
RCV000563227	p.Asn376Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812253A>G	ClinVar
rs777527338	p.Asn376Asp	missense variant	-	NC_000016.10:g.68812252A>G	ExAC,gnomAD
RCV000492512	p.Thr378Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812257del	ClinVar
rs587781432	p.Thr378Pro	missense variant	-	NC_000016.10:g.68812258A>C	ExAC,gnomAD
RCV000129325	p.Thr378Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812258A>C	ClinVar
RCV000759721	p.Thr378Pro	missense variant	-	NC_000016.10:g.68812258A>C	ClinVar
RCV000526444	p.Thr378Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812258A>C	ClinVar
RCV000132465	p.Thr379Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68812262C>T	ClinVar
RCV000480330	p.Thr379Met	missense variant	-	NC_000016.10:g.68812262C>T	ClinVar
rs587782856	p.Thr379Met	missense variant	-	NC_000016.10:g.68812262C>T	ExAC,TOPMed,gnomAD
RCV000227986	p.Thr379Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68812262C>T	ClinVar
RCV000564424	p.Lys381Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813317A>G	ClinVar
RCV000160388	p.Lys381Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813318G>C	ClinVar
rs756938071	p.Lys381Glu	missense variant	-	NC_000016.10:g.68813316A>G	ExAC,gnomAD
rs780867132	p.Lys381Arg	missense variant	-	NC_000016.10:g.68813317A>G	ExAC,gnomAD
RCV000168152	p.Lys381Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813318G>C	ClinVar
RCV000589641	p.Lys381Asn	missense variant	-	NC_000016.10:g.68813318G>C	ClinVar
rs143727462	p.Lys381Asn	missense variant	-	NC_000016.10:g.68813318G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Lys381Asn	missense variant	-	NC_000016.10:g.68813318G>T	NCI-TCGA
RCV000581370	p.Gly382Ter	frameshift	-	NC_000016.10:g.68813320del	ClinVar
RCV000776872	p.Gly382Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813320G>T	ClinVar
RCV000233683	p.Gln383His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813324G>C	ClinVar
RCV000763385	p.Gln383Ter	nonsense	Familial cancer of breast	NC_000016.10:g.68813322C>T	ClinVar
RCV000484108	p.Gln383His	missense variant	-	NC_000016.10:g.68813324G>C	ClinVar
rs786202510	p.Gln383His	missense variant	-	NC_000016.10:g.68813324G>C	gnomAD
rs587782798	p.Gln383Ter	stop gained	-	NC_000016.10:g.68813322C>T	-
RCV000165354	p.Gln383His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813324G>C	ClinVar
RCV000132351	p.Gln383Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813322C>T	ClinVar
RCV000217738	p.Pro385Thr	missense variant	-	NC_000016.10:g.68813328C>A	ClinVar
RCV000639212	p.Pro385Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813328C>A	ClinVar
rs587781612	p.Pro385Thr	missense variant	-	NC_000016.10:g.68813328C>A	-
RCV000129700	p.Pro385Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813328C>A	ClinVar
COSM1302178	p.Glu386Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68813331G>A	NCI-TCGA Cosmic
RCV000774767	p.Asn387Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813335A>G	ClinVar
rs779426744	p.Asn387Thr	missense variant	-	NC_000016.10:g.68813335A>C	ExAC,TOPMed,gnomAD
rs779426744	p.Asn387Ser	missense variant	-	NC_000016.10:g.68813335A>G	ExAC,TOPMed,gnomAD
rs111266450	p.Asn387Lys	missense variant	-	NC_000016.10:g.68813336C>A	1000Genomes,ExAC,TOPMed,gnomAD
RCV000580859	p.Asn387Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813336C>A	ClinVar
RCV000688765	p.Asn387Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813336C>A	ClinVar
RCV000196601	p.Glu388Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813337G>A	ClinVar
rs372838203	p.Glu388Lys	missense variant	-	NC_000016.10:g.68813337G>A	ESP,ExAC,TOPMed,gnomAD
RCV000551677	p.Ala389Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813341C>T	ClinVar
rs1555515869	p.Ala389Val	missense variant	-	NC_000016.10:g.68813341C>T	-
rs964044070	p.Asn390Ser	missense variant	-	NC_000016.10:g.68813344A>G	-
RCV000540402	p.Asn390Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813344A>G	ClinVar
RCV000696664	p.Asn390Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813345del	ClinVar
RCV000525408	p.Asn390Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813343A>G	ClinVar
rs1555515870	p.Asn390Asp	missense variant	-	NC_000016.10:g.68813343A>G	-
RCV000565269	p.Val391Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813347T>G	ClinVar
RCV000160389	p.Val391Phe	missense variant	-	NC_000016.10:g.68813346G>T	ClinVar
RCV000555134	p.Val391Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813347T>C	ClinVar
rs556110297	p.Val391Ile	missense variant	-	NC_000016.10:g.68813346G>A	1000Genomes,ExAC,TOPMed,gnomAD
RCV000409091	p.Val391Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813346G>A	ClinVar
RCV000163940	p.Val391Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813346G>A	ClinVar
RCV000765303	p.Val391Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813346G>A	ClinVar
rs556110297	p.Val391Phe	missense variant	-	NC_000016.10:g.68813346G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1555515873	p.Val391Ala	missense variant	-	NC_000016.10:g.68813347T>C	-
RCV000757068	p.Val391Ile	missense variant	-	NC_000016.10:g.68813346G>A	ClinVar
rs1555515873	p.Val391Gly	missense variant	-	NC_000016.10:g.68813347T>G	-
RCV000167905	p.Val392Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813349G>A	ClinVar
RCV000115835	p.Val392Ile	missense variant	-	NC_000016.10:g.68813349G>A	ClinVar
rs141864044	p.Val392Ile	missense variant	-	NC_000016.10:g.68813349G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000130500	p.Ile393Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813353T>A	ClinVar
RCV000679557	p.Ile393Asn	missense variant	-	NC_000016.10:g.68813353T>A	ClinVar
RCV000212361	p.Ile393Asn	missense variant	-	NC_000016.10:g.68813353T>A	ClinVar
RCV000459515	p.Ile393Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813353T>A	ClinVar
RCV000561469	p.Ile393Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813352A>G	ClinVar
rs1555515877	p.Ile393Val	missense variant	-	NC_000016.10:g.68813352A>G	-
rs34466743	p.Ile393Asn	missense variant	-	NC_000016.10:g.68813353T>A	UniProt,dbSNP
VAR_048501	p.Ile393Asn	missense variant	-	NC_000016.10:g.68813353T>A	UniProt
rs34466743	p.Ile393Asn	missense variant	-	NC_000016.10:g.68813353T>A	ExAC,TOPMed,gnomAD
RCV000761002	p.Thr394Asn	missense variant	Medulloblastoma (MDB)	NC_000016.10:g.68813356C>A	ClinVar
RCV000773939	p.Thr394Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813355A>G	ClinVar
rs1332444039	p.Thr394Ile	missense variant	-	NC_000016.10:g.68813356C>T	gnomAD
RCV000234350	p.Thr395Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813358A>G	ClinVar
RCV000129957	p.Thr395Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813359C>T	ClinVar
RCV000485174	p.Thr395Ala	missense variant	-	NC_000016.10:g.68813358A>G	ClinVar
RCV000221628	p.Thr395Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813358A>G	ClinVar
rs587781751	p.Thr395Ile	missense variant	-	NC_000016.10:g.68813359C>T	-
rs201135424	p.Thr395Ala	missense variant	-	NC_000016.10:g.68813358A>G	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Lys397MetPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68813360_68813369ACTGAAAGTG>-	NCI-TCGA
RCV000772375	p.Asp400Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813375T>G	ClinVar
COSM4062183	p.Asp400Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68813374A>T	NCI-TCGA Cosmic
VAR_001312	p.Asp400del	inframe_deletion	-	-	UniProt
RCV000486692	p.Ala401Asp	missense variant	-	NC_000016.10:g.68813377C>A	ClinVar
RCV000569272	p.Ala401Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813377C>T	ClinVar
RCV000639286	p.Ala401Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813377C>A	ClinVar
RCV000781218	p.Ala401Val	missense variant	-	NC_000016.10:g.68813377C>T	ClinVar
RCV000528041	p.Ala401Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813377C>T	ClinVar
rs150795245	p.Ala401Asp	missense variant	-	NC_000016.10:g.68813377C>A	ESP,ExAC,TOPMed,gnomAD
RCV000566539	p.Ala401Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813377C>A	ClinVar
RCV000478784	p.Ala401Val	missense variant	-	NC_000016.10:g.68813377C>T	ClinVar
rs150795245	p.Ala401Val	missense variant	-	NC_000016.10:g.68813377C>T	ESP,ExAC,TOPMed,gnomAD
rs553525438	p.Ala401Thr	missense variant	-	NC_000016.10:g.68813376G>A	1000Genomes
NCI-TCGA novel	p.Ala401SerPheSerTerUnk	frameshift	-	NC_000016.10:g.68813375_68813376insA	NCI-TCGA
COSM143801	p.Asp402His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68813379G>C	NCI-TCGA Cosmic
COSM972788	p.Ala403Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68813382G>A	NCI-TCGA Cosmic
RCV000772555	p.Pro404Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813385C>G	ClinVar
rs1334047600	p.Pro404Ser	missense variant	-	NC_000016.10:g.68813385C>T	gnomAD
RCV000564371	p.Asn405Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813388A>G	ClinVar
RCV000120513	p.Asn405Ser	missense variant	-	NC_000016.10:g.68813389A>G	ClinVar
RCV000583178	p.Asn405Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813390T>A	ClinVar
RCV000656821	p.Asn405Ser	missense variant	-	NC_000016.10:g.68813389A>G	ClinVar
RCV000639251	p.Asn405Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813388A>G	ClinVar
rs1336921050	p.Asn405Asp	missense variant	-	NC_000016.10:g.68813388A>G	gnomAD
rs587778175	p.Asn405Ser	missense variant	-	NC_000016.10:g.68813389A>G	ExAC,TOPMed,gnomAD
rs1555515891	p.Asn405Lys	missense variant	-	NC_000016.10:g.68813390T>A	-
RCV000129759	p.Asn405Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813389A>G	ClinVar
RCV000198487	p.Asn405Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813389A>G	ClinVar
rs1445178301	p.Thr406Ser	missense variant	-	NC_000016.10:g.68813391A>T	gnomAD
rs753770270	p.Thr406Ile	missense variant	-	NC_000016.10:g.68813392C>T	ExAC,gnomAD
rs1060501236	p.Pro407Leu	missense variant	-	NC_000016.10:g.68813395C>T	-
RCV000467830	p.Pro407Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813395C>T	ClinVar
RCV000240878	p.Pro407Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813395del	ClinVar
RCV000115836	p.Ala408Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813398C>T	ClinVar
RCV000562112	p.Ala408Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813398C>G	ClinVar
rs138135866	p.Ala408Val	missense variant	-	NC_000016.10:g.68813398C>T	ESP,ExAC,TOPMed,gnomAD
RCV000204897	p.Ala408Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813398C>G	ClinVar
rs138135866	p.Ala408Gly	missense variant	-	NC_000016.10:g.68813398C>G	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala408Pro	missense variant	-	NC_000016.10:g.68813397G>C	NCI-TCGA
RCV000120515	p.Trp409Arg	missense variant	-	NC_000016.10:g.68813400T>C	ClinVar
COSM1479025	p.Trp409Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68813401G>T	NCI-TCGA Cosmic
rs587778176	p.Trp409Arg	missense variant	-	NC_000016.10:g.68813400T>C	ExAC,TOPMed,gnomAD
rs187906987	p.Glu410Lys	missense variant	-	NC_000016.10:g.68813403G>A	1000Genomes
RCV000228207	p.Glu410Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813403G>C	ClinVar
rs187906987	p.Glu410Gln	missense variant	-	NC_000016.10:g.68813403G>C	1000Genomes
RCV000168411	p.Val412Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813409G>A	ClinVar
RCV000130820	p.Val412Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813409G>A	ClinVar
rs587782189	p.Val412Ile	missense variant	-	NC_000016.10:g.68813409G>A	-
RCV000200507	p.Thr414Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813415A>G	ClinVar
RCV000466208	p.Thr414Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813416C>A	ClinVar
RCV000564236	p.Thr414Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813416C>T	ClinVar
RCV000590115	p.Thr414Asn	missense variant	-	NC_000016.10:g.68813416C>A	ClinVar
RCV000561646	p.Thr414Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813416C>G	ClinVar
rs755571454	p.Thr414Asn	missense variant	-	NC_000016.10:g.68813416C>A	ExAC,TOPMed,gnomAD
rs755571454	p.Thr414Ser	missense variant	-	NC_000016.10:g.68813416C>G	ExAC,TOPMed,gnomAD
RCV000565479	p.Thr414Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813415A>G	ClinVar
RCV000164120	p.Thr414Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813416C>A	ClinVar
rs863224723	p.Thr414Ala	missense variant	-	NC_000016.10:g.68813415A>G	-
rs755571454	p.Thr414Ile	missense variant	-	NC_000016.10:g.68813416C>T	ExAC,TOPMed,gnomAD
RCV000464498	p.Ile415Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813418A>G	ClinVar
RCV000462419	p.Ile415Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813419T>C	ClinVar
RCV000131355	p.Ile415Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813419T>C	ClinVar
RCV000773438	p.Ile415Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813409_68813410dup	ClinVar
rs587782372	p.Ile415Thr	missense variant	-	NC_000016.10:g.68813419T>C	ExAC,TOPMed,gnomAD
rs1060501239	p.Ile415Val	missense variant	-	NC_000016.10:g.68813418A>G	gnomAD
RCV000759725	p.Ile415Thr	missense variant	-	NC_000016.10:g.68813419T>C	ClinVar
RCV000492243	p.Ile415Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813410_68813411TA[3]	ClinVar
rs772622537	p.Leu416Phe	missense variant	-	NC_000016.10:g.68813423G>C	ExAC,gnomAD
RCV000164676	p.Asn417Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813425A>G	ClinVar
RCV000579872	p.Asn417Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813426T>A	ClinVar
RCV000484306	p.Asn417Ser	missense variant	-	NC_000016.10:g.68813425A>G	ClinVar
RCV000766705	p.Asn417Ser	missense variant	-	NC_000016.10:g.68813425A>G	ClinVar
RCV000196904	p.Asn417Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813425A>G	ClinVar
RCV000765304	p.Asn417Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813425A>G	ClinVar
rs1555515902	p.Asn417Lys	missense variant	-	NC_000016.10:g.68813426T>A	-
rs773441320	p.Asn417Ser	missense variant	-	NC_000016.10:g.68813425A>G	ExAC,TOPMed,gnomAD
rs1379626654	p.Asp418Ala	missense variant	-	NC_000016.10:g.68813428A>C	gnomAD
VAR_001313	p.Asp418_Phe423del	inframe_deletion	-	-	UniProt
RCV000225994	p.Gly420Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813434G>A	ClinVar
rs878854677	p.Gly420Asp	missense variant	-	NC_000016.10:g.68813434G>A	gnomAD
RCV000561551	p.Gly421Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813436G>A	ClinVar
RCV000817343	p.Gly421Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813436G>A	ClinVar
rs747256664	p.Gly421Arg	missense variant	-	NC_000016.10:g.68813436G>A	ExAC,gnomAD
RCV000164628	p.Phe423Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813442T>C	ClinVar
RCV000794163	p.Phe423Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813442T>C	ClinVar
rs786202027	p.Phe423Leu	missense variant	-	NC_000016.10:g.68813442T>C	-
RCV000573495	p.Val424Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813446T>C	ClinVar
rs1555515904	p.Val424Ala	missense variant	-	NC_000016.10:g.68813446T>C	-
RCV000552405	p.Val425Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813448G>C	ClinVar
RCV000115837	p.Val425Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813448G>A	ClinVar
rs570930882	p.Val425Ile	missense variant	-	NC_000016.10:g.68813448G>A	1000Genomes,ExAC,TOPMed,gnomAD
RCV000583760	p.Val425Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813448G>C	ClinVar
rs570930882	p.Val425Leu	missense variant	-	NC_000016.10:g.68813448G>C	1000Genomes,ExAC,TOPMed,gnomAD
RCV000217681	p.Thr426Ile	missense variant	-	NC_000016.10:g.68813452C>T	ClinVar
RCV000698860	p.Thr426Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813452C>T	ClinVar
rs876658901	p.Thr426Ile	missense variant	-	NC_000016.10:g.68813452C>T	-
RCV000216022	p.Thr426Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813452C>T	ClinVar
rs1064793864	p.Thr427Ala	missense variant	-	NC_000016.10:g.68813454A>G	-
RCV000481994	p.Thr427Ala	missense variant	-	NC_000016.10:g.68813454A>G	ClinVar
RCV000563519	p.Thr427Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813454A>G	ClinVar
RCV000639269	p.Thr427Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813454A>G	ClinVar
rs876658766	p.Pro429Leu	missense variant	-	NC_000016.10:g.68813461C>T	-
RCV000216574	p.Pro429Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813461C>T	ClinVar
RCV000160391	p.Val430Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813464T>G	ClinVar
RCV000200679	p.Val430Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813464T>G	ClinVar
RCV000212364	p.Val430Gly	missense variant	-	NC_000016.10:g.68813464T>G	ClinVar
rs730881665	p.Val430Gly	missense variant	-	NC_000016.10:g.68813464T>G	ExAC,TOPMed,gnomAD
RCV000530703	p.Val430Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813464T>C	ClinVar
rs730881665	p.Val430Ala	missense variant	-	NC_000016.10:g.68813464T>C	ExAC,TOPMed,gnomAD
COSM5833147	p.Asn431GlnPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68813466_68813467AA>-	NCI-TCGA Cosmic
rs767350265	p.Asn431Lys	missense variant	-	NC_000016.10:g.68813468C>G	ExAC,gnomAD
RCV000677870	p.Asn432Lys	missense variant	Neoplasm of stomach	NC_000016.10:g.68813471C>G	ClinVar
rs1230641631	p.Asn432Ser	missense variant	-	NC_000016.10:g.68813470A>G	gnomAD
rs187862045	p.Asn432Lys	missense variant	-	NC_000016.10:g.68813471C>G	1000Genomes,ExAC,TOPMed,gnomAD
RCV000196288	p.Asp433Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813473A>G	ClinVar
RCV000115838	p.Asp433Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813472G>A	ClinVar
rs376097289	p.Asp433Gly	missense variant	-	NC_000016.10:g.68813473A>G	ExAC,TOPMed,gnomAD
rs199886166	p.Asp433Asn	missense variant	-	NC_000016.10:g.68813472G>A	ExAC,TOPMed,gnomAD
RCV000546847	p.Gly434Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813476G>A	ClinVar
RCV000130036	p.Gly434Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813475G>C	ClinVar
rs1555515914	p.Gly434Asp	missense variant	-	NC_000016.10:g.68813476G>A	-
rs587781783	p.Gly434Arg	missense variant	-	NC_000016.10:g.68813475G>C	TOPMed,gnomAD
RCV000197039	p.Gly434Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813475G>C	ClinVar
RCV000566585	p.Ile435Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813478A>G	ClinVar
RCV000519205	p.Ile435Val	missense variant	-	NC_000016.10:g.68813478A>G	ClinVar
RCV000204180	p.Ile435Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813478A>G	ClinVar
rs864622644	p.Ile435Val	missense variant	-	NC_000016.10:g.68813478A>G	gnomAD
RCV000557005	p.Leu436Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813481T>A	ClinVar
rs1555515917	p.Leu436Met	missense variant	-	NC_000016.10:g.68813481T>A	-
rs786201841	p.Lys437Gln	missense variant	-	NC_000016.10:g.68813484A>C	-
RCV000531017	p.Lys437Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813484A>C	ClinVar
RCV000164334	p.Lys437Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813484A>C	ClinVar
RCV000215360	p.Thr438Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813488C>G	ClinVar
RCV000657359	p.Thr438Ter	frameshift	-	NC_000016.10:g.68813487del	ClinVar
rs876658218	p.Thr438Arg	missense variant	-	NC_000016.10:g.68813488C>G	-
RCV000164296	p.Ala439Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813490G>A	ClinVar
RCV000168147	p.Ala439Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813490G>A	ClinVar
RCV000218750	p.Ala439Thr	missense variant	-	NC_000016.10:g.68813490G>A	ClinVar
rs758764445	p.Ala439Thr	missense variant	-	NC_000016.10:g.68813490G>A	ExAC,gnomAD
RCV000639244	p.Lys440Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813493A>G	ClinVar
RCV000218352	p.Lys440Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813493A>G	ClinVar
RCV000505716	p.Lys440Asn	missense variant	Ectropion inferior cleft lip and or palate (BCDS1)	NC_000016.10:g.68813495G>T	ClinVar
rs778212100	p.Lys440Glu	missense variant	-	NC_000016.10:g.68813493A>G	ExAC,TOPMed,gnomAD
rs864622165	p.Lys440Arg	missense variant	-	NC_000016.10:g.68813494A>G	TOPMed,gnomAD
RCV000218783	p.Lys440Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68813494A>G	ClinVar
RCV000206579	p.Lys440Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68813494A>G	ClinVar
rs1555515925	p.Lys440Asn	missense variant	-	NC_000016.10:g.68813495G>T	-
RCV000213773	p.Leu442Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815519T>C	ClinVar
RCV000583583	p.Leu442Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815520G>C	ClinVar
RCV000228858	p.Leu442Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815519T>C	ClinVar
rs752074266	p.Leu442Ser	missense variant	-	NC_000016.10:g.68815519T>C	ExAC,TOPMed,gnomAD
rs1555516080	p.Leu442Phe	missense variant	-	NC_000016.10:g.68815520G>C	-
rs1555516083	p.Asp443Gly	missense variant	-	NC_000016.10:g.68815522A>G	-
RCV000566387	p.Asp443Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815522A>G	ClinVar
RCV000776725	p.Phe444Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815526T>A	ClinVar
rs1392114487	p.Phe444Leu	missense variant	-	NC_000016.10:g.68815526T>A	TOPMed
RCV000560722	p.Phe444Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815526T>A	ClinVar
RCV000205448	p.Glu445Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815527G>C	ClinVar
RCV000115839	p.Glu445Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815528A>C	ClinVar
RCV000212366	p.Glu445Ala	missense variant	-	NC_000016.10:g.68815528A>C	ClinVar
RCV000123235	p.Glu445Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815528A>C	ClinVar
rs864622184	p.Glu445Gln	missense variant	-	NC_000016.10:g.68815527G>C	-
rs374398608	p.Glu445Ala	missense variant	-	NC_000016.10:g.68815528A>C	ESP,ExAC,TOPMed,gnomAD
RCV000217435	p.Ala446Thr	missense variant	-	NC_000016.10:g.68815530G>A	ClinVar
rs876661078	p.Ala446Thr	missense variant	-	NC_000016.10:g.68815530G>A	-
RCV000534484	p.Ala446Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815530G>A	ClinVar
RCV000505868	p.Lys447Ter	frameshift	-	NC_000016.10:g.68815535del	ClinVar
rs767885546	p.Lys447Asn	missense variant	-	NC_000016.10:g.68815535G>C	ExAC,gnomAD
RCV000639223	p.Gln448Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815536C>G	ClinVar
rs1421067964	p.Gln448Glu	missense variant	-	NC_000016.10:g.68815536C>G	gnomAD
NCI-TCGA novel	p.Gln449Lys	missense variant	-	NC_000016.10:g.68815539C>A	NCI-TCGA
RCV000780092	p.Tyr450Asn	missense variant	-	NC_000016.10:g.68815542T>A	ClinVar
RCV000486827	p.Tyr450Asn	missense variant	-	NC_000016.10:g.68815542T>A	ClinVar
RCV000165468	p.Tyr450Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815542T>A	ClinVar
RCV000167939	p.Tyr450Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815542T>A	ClinVar
RCV000639277	p.Tyr450Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815542T>G	ClinVar
rs750741214	p.Tyr450Asn	missense variant	-	NC_000016.10:g.68815542T>A	ExAC,TOPMed,gnomAD
rs750741214	p.Tyr450Asp	missense variant	-	NC_000016.10:g.68815542T>G	ExAC,TOPMed,gnomAD
RCV000132204	p.Ile451Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815545A>C	ClinVar
RCV000586976	p.Ile451Leu	missense variant	-	NC_000016.10:g.68815545A>C	ClinVar
RCV000475311	p.Ile451Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815545A>C	ClinVar
rs377416092	p.Ile451Leu	missense variant	-	NC_000016.10:g.68815545A>C	ESP,ExAC,TOPMed,gnomAD
RCV000256004	p.Leu452Ter	frameshift	-	NC_000016.10:g.68815548_68815551del	ClinVar
RCV000212369	p.Val454Ile	missense variant	-	NC_000016.10:g.68815554G>A	ClinVar
RCV000115840	p.Val454Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815554G>A	ClinVar
RCV000226677	p.Val454Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815554G>A	ClinVar
rs587780112	p.Val454Leu	missense variant	-	NC_000016.10:g.68815554G>C	ExAC,TOPMed,gnomAD
rs587780112	p.Val454Ile	missense variant	-	NC_000016.10:g.68815554G>A	ExAC,TOPMed,gnomAD
RCV000581224	p.Val454Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815554G>C	ClinVar
VAR_079394	p.Val454del	inframe_deletion	Blepharocheilodontic syndrome 1 (BCDS1) [MIM:119580]	-	UniProt
RCV000222712	p.Ala455Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815557G>T	ClinVar
RCV000702799	p.Ala455Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815557G>A	ClinVar
rs876659762	p.Ala455Thr	missense variant	-	NC_000016.10:g.68815557G>A	-
rs876659762	p.Ala455Ser	missense variant	-	NC_000016.10:g.68815557G>T	-
rs974965262	p.Val456Met	missense variant	-	NC_000016.10:g.68815560G>A	TOPMed
RCV000549556	p.Val456Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815560G>A	ClinVar
RCV000765305	p.Thr457Met	missense variant	Familial cancer of breast	NC_000016.10:g.68815564C>T	ClinVar
RCV000657011	p.Thr457Met	missense variant	-	NC_000016.10:g.68815564C>T	ClinVar
RCV000229532	p.Thr457Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815564C>T	ClinVar
rs587778170	p.Thr457Met	missense variant	-	NC_000016.10:g.68815564C>T	ExAC,gnomAD
RCV000219561	p.Thr457Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815564C>T	ClinVar
rs1555516109	p.Val459Ala	missense variant	-	NC_000016.10:g.68815570T>C	-
RCV000774023	p.Val459Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815569G>A	ClinVar
RCV000572988	p.Val459Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815570T>C	ClinVar
COSM6079791	p.Val460Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68815572G>T	NCI-TCGA Cosmic
RCV000216598	p.Pro461Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815576C>T	ClinVar
RCV000773621	p.Pro461Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815574del	ClinVar
COSM3511253	p.Pro461Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68815575C>T	NCI-TCGA Cosmic
rs1355592880	p.Pro461Thr	missense variant	-	NC_000016.10:g.68815575C>A	gnomAD
rs876659268	p.Pro461Leu	missense variant	-	NC_000016.10:g.68815576C>T	-
RCV000132005	p.Phe462Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815579T>C	ClinVar
COSM4613898	p.Phe462LeuPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68815577T>-	NCI-TCGA Cosmic
rs587782622	p.Phe462Ser	missense variant	-	NC_000016.10:g.68815579T>C	-
VAR_001314	p.Glu463Gln	Missense	-	-	UniProt
RCV000574458	p.Val464Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815584del	ClinVar
rs776588895	p.Ser465Pro	missense variant	-	NC_000016.10:g.68815587T>C	ExAC,gnomAD
RCV000800375	p.Thr468Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815597C>T	ClinVar
RCV000219425	p.Thr468Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815597C>T	ClinVar
RCV000164713	p.Thr468Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815596A>G	ClinVar
rs745617489	p.Thr468Ala	missense variant	-	NC_000016.10:g.68815596A>G	ExAC,gnomAD
rs876659141	p.Thr468Ile	missense variant	-	NC_000016.10:g.68815597C>T	-
RCV000115841	p.Thr470Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815603C>T	ClinVar
RCV000200980	p.Thr470Ile	missense variant	-	NC_000016.10:g.68815603C>T	ClinVar
RCV000492349	p.Thr470Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815602del	ClinVar
rs370864592	p.Thr470Ile	missense variant	-	NC_000016.10:g.68815603C>T	UniProt,dbSNP
VAR_001315	p.Thr470Ile	missense variant	-	NC_000016.10:g.68815603C>T	UniProt
rs370864592	p.Thr470Ile	missense variant	-	NC_000016.10:g.68815603C>T	ExAC,TOPMed,gnomAD
RCV000212370	p.Val473Ile	missense variant	-	NC_000016.10:g.68815611G>A	ClinVar
RCV000198903	p.Val473Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815611G>A	ClinVar
RCV000780096	p.Val473Ile	missense variant	-	NC_000016.10:g.68815611G>A	ClinVar
rs36087757	p.Val473Ile	missense variant	-	NC_000016.10:g.68815611G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs36087757	p.Val473Ile	missense variant	-	NC_000016.10:g.68815611G>A	UniProt,dbSNP
VAR_048502	p.Val473Ile	missense variant	-	NC_000016.10:g.68815611G>A	UniProt
VAR_001317	p.Val473Asp	Missense	-	-	UniProt
RCV000547309	p.Thr474Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815615C>T	ClinVar
RCV000564220	p.Thr474Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815615C>T	ClinVar
RCV000570136	p.Thr474Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815614A>G	ClinVar
rs773858736	p.Thr474Ala	missense variant	-	NC_000016.10:g.68815614A>G	ExAC,gnomAD
rs1555516124	p.Thr474Ile	missense variant	-	NC_000016.10:g.68815615C>T	-
RCV000130629	p.Val475Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815617G>A	ClinVar
RCV000470134	p.Val475Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815617G>A	ClinVar
rs587782113	p.Val475Met	missense variant	-	NC_000016.10:g.68815617G>A	ExAC,TOPMed,gnomAD
rs1060501217	p.Val475Ala	missense variant	-	NC_000016.10:g.68815618T>C	-
RCV000475500	p.Val475Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815618T>C	ClinVar
rs1177546897	p.Asp476Ala	missense variant	-	NC_000016.10:g.68815621A>C	gnomAD
RCV000131315	p.Leu478Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815627T>C	ClinVar
RCV000702004	p.Leu478Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815627T>C	ClinVar
rs35520415	p.Leu478Pro	missense variant	-	NC_000016.10:g.68815627T>C	-
RCV000579753	p.Asp479Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815629G>A	ClinVar
RCV000540606	p.Asp479Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815630A>G	ClinVar
RCV000567936	p.Asp479Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815630A>G	ClinVar
rs1555516131	p.Asp479Gly	missense variant	-	NC_000016.10:g.68815630A>G	-
RCV000582796	p.Asp479Asn	missense variant	-	NC_000016.10:g.68815629G>A	ClinVar
rs587782796	p.Asp479His	missense variant	-	NC_000016.10:g.68815629G>C	gnomAD
rs587782796	p.Asp479Asn	missense variant	-	NC_000016.10:g.68815629G>A	gnomAD
RCV000132346	p.Asp479His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815629G>C	ClinVar
RCV000525890	p.Asp479Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815629G>A	ClinVar
NCI-TCGA novel	p.Asp479AlaPheSerTerUnk	frameshift	-	NC_000016.10:g.68815612_68815613insCACCGTGGATGTGCTGG	NCI-TCGA
RCV000165603	p.Val480Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815632G>A	ClinVar
rs786202675	p.Val480Met	missense variant	-	NC_000016.10:g.68815632G>A	-
RCV000801471	p.Val480Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815632G>A	ClinVar
RCV000584079	p.Asn481Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815637del	ClinVar
RCV000582812	p.Asn481His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815635A>C	ClinVar
rs1555516133	p.Asn481His	missense variant	-	NC_000016.10:g.68815635A>C	-
RCV000216175	p.Glu482Asp	missense variant	-	NC_000016.10:g.68815640A>T	ClinVar
RCV000561678	p.Glu482Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815638G>A	ClinVar
rs863224724	p.Glu482Asp	missense variant	-	NC_000016.10:g.68815640A>T	TOPMed,gnomAD
rs1555516138	p.Glu482Lys	missense variant	-	NC_000016.10:g.68815638G>A	-
RCV000196042	p.Glu482Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815640A>T	ClinVar
RCV000575121	p.Ile485Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815648T>C	ClinVar
rs587783049	p.Ile485Thr	missense variant	-	NC_000016.10:g.68815648T>C	TOPMed
RCV000569112	p.Ile485Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815647A>G	ClinVar
rs1555516140	p.Ile485Val	missense variant	-	NC_000016.10:g.68815647A>G	-
rs587783049	p.Ile485Ser	missense variant	-	NC_000016.10:g.68815648T>G	TOPMed
RCV000144592	p.Ile485Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815648T>G	ClinVar
RCV000780088	p.Ile485Thr	missense variant	-	NC_000016.10:g.68815648T>C	ClinVar
rs1331977824	p.Phe486Ile	missense variant	-	NC_000016.10:g.68815650T>A	gnomAD
rs1331977824	p.Phe486Val	missense variant	-	NC_000016.10:g.68815650T>G	gnomAD
RCV000687067	p.Val487Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815652_68815653TG[1]	ClinVar
VAR_008713	p.Val487Ala	Missense	Hereditary diffuse gastric cancer (HDGC) [MIM:137215]	-	UniProt
RCV000705192	p.Pro488Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815656C>G	ClinVar
RCV000524883	p.Pro488Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815656C>T	ClinVar
rs1555516144	p.Pro488Ser	missense variant	-	NC_000016.10:g.68815656C>T	-
rs786202508	p.Pro489Ser	missense variant	-	NC_000016.10:g.68815659C>T	-
RCV000707373	p.Pro489Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815659C>T	ClinVar
RCV000165352	p.Pro489Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815659C>T	ClinVar
RCV000230192	p.Pro489Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815660C>T	ClinVar
rs766713582	p.Pro489Leu	missense variant	-	NC_000016.10:g.68815660C>T	ExAC,gnomAD
RCV000539873	p.Glu490Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815662G>A	ClinVar
RCV000565014	p.Glu490Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815662G>A	ClinVar
rs1555516147	p.Glu490Lys	missense variant	-	NC_000016.10:g.68815662G>A	-
RCV000657196	p.Arg492Ter	frameshift	-	NC_000016.10:g.68815666_68815667AG[2]	ClinVar
RCV000212371	p.Arg492Thr	missense variant	-	NC_000016.10:g.68815669G>C	ClinVar
RCV000213871	p.Arg492Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815666_68815667AG[2]	ClinVar
RCV000167912	p.Arg492Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815669G>C	ClinVar
rs587781286	p.Arg492Thr	missense variant	-	NC_000016.10:g.68815669G>C	gnomAD
RCV000554611	p.Arg492Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815666_68815667AG[2]	ClinVar
RCV000772963	p.Arg492Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815669G>A	ClinVar
RCV000128970	p.Arg492Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815669G>C	ClinVar
RCV000165202	p.Val493Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815672T>C	ClinVar
RCV000206225	p.Val493Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815671G>C	ClinVar
RCV000221777	p.Val493Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815671G>C	ClinVar
RCV000160392	p.Val493Leu	missense variant	-	NC_000016.10:g.68815671G>C	ClinVar
rs786202407	p.Val493Ala	missense variant	-	NC_000016.10:g.68815672T>C	TOPMed,gnomAD
rs730881666	p.Val493Leu	missense variant	-	NC_000016.10:g.68815671G>C	ExAC,gnomAD
rs786202407	p.Val493Gly	missense variant	-	NC_000016.10:g.68815672T>G	TOPMed,gnomAD
RCV000639235	p.Glu494Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815675A>G	ClinVar
RCV000574013	p.Glu494Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815674G>T	ClinVar
rs778871891	p.Glu494Ter	stop gained	-	NC_000016.10:g.68815674G>T	ExAC,gnomAD
rs778871891	p.Glu494Gln	missense variant	-	NC_000016.10:g.68815674G>C	ExAC,gnomAD
rs1555516153	p.Glu494Gly	missense variant	-	NC_000016.10:g.68815675A>G	-
rs786202482	p.Val495Ala	missense variant	-	NC_000016.10:g.68815678T>C	TOPMed,gnomAD
RCV000639252	p.Val495Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815678T>C	ClinVar
RCV000165313	p.Val495Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815678T>C	ClinVar
rs931521632	p.Val495Leu	missense variant	-	NC_000016.10:g.68815677G>T	TOPMed
NCI-TCGA novel	p.Val495Gly	missense variant	-	NC_000016.10:g.68815678T>G	NCI-TCGA
RCV000639261	p.Glu497Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815682_68815688del	ClinVar
RCV000222658	p.Glu497Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815682_68815688del	ClinVar
RCV000678466	p.Glu497Lys	missense variant	-	NC_000016.10:g.68815683G>A	ClinVar
NCI-TCGA novel	p.Glu497Ter	stop gained	-	NC_000016.10:g.68815683G>T	NCI-TCGA
RCV000570338	p.Asp498Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815687A>C	ClinVar
RCV000539949	p.Asp498Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815687A>C	ClinVar
RCV000216744	p.Asp498Ala	missense variant	-	NC_000016.10:g.68815687A>C	ClinVar
rs876661065	p.Asp498Ala	missense variant	-	NC_000016.10:g.68815687A>C	gnomAD
rs56836234	p.Asp498Glu	missense variant	-	NC_000016.10:g.68815688C>A	ExAC,gnomAD
RCV000569748	p.Phe499Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815690T>C	ClinVar
COSM1479026	p.Phe499LeuPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68815690_68815691insG	NCI-TCGA Cosmic
rs1555516163	p.Phe499Ser	missense variant	-	NC_000016.10:g.68815690T>C	-
RCV000478959	p.Val501Met	missense variant	-	NC_000016.10:g.68815695G>A	ClinVar
RCV000167909	p.Val501Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815695G>A	ClinVar
rs368690400	p.Val501Met	missense variant	-	NC_000016.10:g.68815695G>A	ESP,ExAC,TOPMed,gnomAD
RCV000131439	p.Val501Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815695G>A	ClinVar
RCV000585007	p.Val501Met	missense variant	-	NC_000016.10:g.68815695G>A	ClinVar
rs368690400	p.Val501Leu	missense variant	-	NC_000016.10:g.68815695G>T	ESP,ExAC,TOPMed,gnomAD
RCV000210159	p.Gly502Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815699del	ClinVar
COSM435600	p.Gln503Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68815701C>T	NCI-TCGA Cosmic
rs876659548	p.Gln503His	missense variant	-	NC_000016.10:g.68815703G>C	-
RCV000214119	p.Gln503His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815703G>C	ClinVar
RCV000570243	p.Glu504Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815704G>A	ClinVar
rs1555516170	p.Glu504Lys	missense variant	-	NC_000016.10:g.68815704G>A	-
COSM435601	p.Ile505SerPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68815705A>-	NCI-TCGA Cosmic
RCV000217270	p.Thr506Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815710A>G	ClinVar
RCV000554984	p.Thr506Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815710A>G	ClinVar
rs114885938	p.Thr506Ala	missense variant	-	NC_000016.10:g.68815710A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs1402430481	p.Ser507Thr	missense variant	-	NC_000016.10:g.68815713T>A	gnomAD
rs1402430481	p.Ser507Pro	missense variant	-	NC_000016.10:g.68815713T>C	gnomAD
RCV000533273	p.Tyr508Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815716T>A	ClinVar
rs1240947148	p.Tyr508Ser	missense variant	-	NC_000016.10:g.68815717A>C	TOPMed
rs1555516173	p.Tyr508Asn	missense variant	-	NC_000016.10:g.68815716T>A	-
RCV000232572	p.Thr509Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815720C>A	ClinVar
rs771551231	p.Thr509Ile	missense variant	-	NC_000016.10:g.68815720C>T	ExAC,TOPMed,gnomAD
RCV000571668	p.Thr509Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815720C>A	ClinVar
RCV000568081	p.Thr509Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815719A>C	ClinVar
RCV000679562	p.Thr509Asn	missense variant	-	NC_000016.10:g.68815720C>A	ClinVar
RCV000482892	p.Thr509Ile	missense variant	-	NC_000016.10:g.68815720C>T	ClinVar
RCV000218463	p.Thr509Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815720C>G	ClinVar
rs771551231	p.Thr509Ser	missense variant	-	NC_000016.10:g.68815720C>G	ExAC,TOPMed,gnomAD
rs771551231	p.Thr509Asn	missense variant	-	NC_000016.10:g.68815720C>A	ExAC,TOPMed,gnomAD
rs761356661	p.Thr509Ala	missense variant	-	NC_000016.10:g.68815719A>G	ExAC,gnomAD
rs761356661	p.Thr509Pro	missense variant	-	NC_000016.10:g.68815719A>C	ExAC,gnomAD
rs1273354402	p.Ala510Ser	missense variant	-	NC_000016.10:g.68815722G>T	gnomAD
COSM1379179	p.Ala510Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68815722G>A	NCI-TCGA Cosmic
rs1344960746	p.Ala510Val	missense variant	-	NC_000016.10:g.68815723C>T	gnomAD
RCV000475195	p.Gln511His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815727G>T	ClinVar
RCV000215502	p.Gln511His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815727G>T	ClinVar
RCV000759009	p.Gln511His	missense variant	-	NC_000016.10:g.68815727G>T	ClinVar
RCV000584335	p.Gln511Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815726A>G	ClinVar
rs1555516178	p.Gln511Arg	missense variant	-	NC_000016.10:g.68815726A>G	-
rs876658342	p.Gln511His	missense variant	-	NC_000016.10:g.68815727G>T	-
RCV000492683	p.Gln511Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815725C>T	ClinVar
RCV000810270	p.Gln511Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815725C>T	ClinVar
rs1131690810	p.Gln511Ter	stop gained	-	NC_000016.10:g.68815725C>T	-
COSM3818353	p.Glu512Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68815728G>T	NCI-TCGA Cosmic
rs876659244	p.Glu512Lys	missense variant	-	NC_000016.10:g.68815728G>A	-
RCV000220568	p.Glu512Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815728G>A	ClinVar
NCI-TCGA novel	p.Glu512Val	missense variant	-	NC_000016.10:g.68815729A>T	NCI-TCGA
RCV000566094	p.Pro513Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815732C>T	ClinVar
rs1555516185	p.Pro513Leu	missense variant	-	NC_000016.10:g.68815732C>T	-
RCV000586505	p.Asp514Glu	missense variant	-	NC_000016.10:g.68815736C>G	ClinVar
rs1555516188	p.Thr515Ile	missense variant	-	NC_000016.10:g.68815738C>T	-
RCV000639273	p.Thr515Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815738C>T	ClinVar
COSM5833148	p.Thr515Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68815738_68815739insATA	NCI-TCGA Cosmic
RCV000772954	p.Thr515Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815738C>T	ClinVar
RCV000699314	p.Thr515Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815737A>T	ClinVar
rs1219371636	p.Thr515Ala	missense variant	-	NC_000016.10:g.68815737A>G	gnomAD
RCV000221624	p.Met517Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815743A>G	ClinVar
RCV000213736	p.Met517Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815744T>C	ClinVar
RCV000794319	p.Met517Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815743A>G	ClinVar
rs786203656	p.Met517Thr	missense variant	-	NC_000016.10:g.68815744T>C	-
RCV000543755	p.Met517Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815744T>A	ClinVar
RCV000167059	p.Met517Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815744T>A	ClinVar
rs876658146	p.Met517Val	missense variant	-	NC_000016.10:g.68815743A>G	-
rs786203656	p.Met517Lys	missense variant	-	NC_000016.10:g.68815744T>A	-
rs786203656	p.Met517Arg	missense variant	-	NC_000016.10:g.68815744T>G	-
RCV000216206	p.Met517Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815744T>G	ClinVar
COSM435603	p.Glu518AsnPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68815745G>-	NCI-TCGA Cosmic
rs773763544	p.Gln519Lys	missense variant	-	NC_000016.10:g.68815749C>A	ExAC,gnomAD
rs1555516192	p.Lys520Glu	missense variant	-	NC_000016.10:g.68815752A>G	-
RCV000558398	p.Lys520Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815752A>G	ClinVar
RCV000772809	p.Lys520Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815753A>C	ClinVar
RCV000772110	p.Ile521Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815755A>G	ClinVar
rs761162838	p.Ile521Met	missense variant	-	NC_000016.10:g.68815757A>G	ExAC,gnomAD
RCV000566861	p.Thr522Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815759C>A	ClinVar
rs863224725	p.Thr522Ile	missense variant	-	NC_000016.10:g.68815759C>T	gnomAD
RCV000590454	p.Thr522Ile	missense variant	-	NC_000016.10:g.68815759C>T	ClinVar
rs863224725	p.Thr522Lys	missense variant	-	NC_000016.10:g.68815759C>A	gnomAD
RCV000448662	p.Thr522Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68815759C>T	ClinVar
RCV000197897	p.Thr522Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68815759C>T	ClinVar
NCI-TCGA novel	p.Thr522IlePheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68815757_68815758AA>-	NCI-TCGA
RCV000561178	p.Tyr523Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819283T>A	ClinVar
RCV000702111	p.Tyr523Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819283T>A	ClinVar
RCV000582485	p.Tyr523His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819281T>C	ClinVar
RCV000129330	p.Tyr523Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819282A>G	ClinVar
RCV000206211	p.Tyr523Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819282A>G	ClinVar
RCV000587509	p.Tyr523Cys	missense variant	-	NC_000016.10:g.68819282A>G	ClinVar
rs876659716	p.Tyr523Ter	stop gained	-	NC_000016.10:g.68819283T>A	gnomAD
rs1473643691	p.Tyr523His	missense variant	-	NC_000016.10:g.68819281T>C	gnomAD
RCV000235156	p.Tyr523Cys	missense variant	-	NC_000016.10:g.68819282A>G	ClinVar
rs553907248	p.Tyr523Cys	missense variant	-	NC_000016.10:g.68819282A>G	1000Genomes,ExAC,TOPMed,gnomAD
RCV000215522	p.Arg524Trp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819284C>T	ClinVar
RCV000163581	p.Arg524Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819284C>G	ClinVar
RCV000216734	p.Arg524Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819285G>A	ClinVar
rs761180883	p.Arg524Gln	missense variant	-	NC_000016.10:g.68819285G>A	ExAC,TOPMed,gnomAD
RCV000481206	p.Arg524Trp	missense variant	-	NC_000016.10:g.68819284C>T	ClinVar
RCV000205600	p.Arg524Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819284C>G	ClinVar
RCV000468047	p.Arg524Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819285G>A	ClinVar
RCV000475606	p.Arg524Trp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819284C>T	ClinVar
rs373605261	p.Arg524Gly	missense variant	-	NC_000016.10:g.68819284C>G	ESP,TOPMed,gnomAD
rs373605261	p.Arg524Trp	missense variant	-	NC_000016.10:g.68819284C>T	ESP,TOPMed,gnomAD
RCV000255230	p.Trp526Ter	nonsense	-	NC_000016.10:g.68819292G>A	ClinVar
rs886039590	p.Trp526Ter	stop gained	-	NC_000016.10:g.68819292G>A	-
rs1204671808	p.Asp528Asn	missense variant	-	NC_000016.10:g.68819296G>A	TOPMed
RCV000691223	p.Thr529Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819299A>C	ClinVar
rs776890776	p.Thr529Pro	missense variant	-	NC_000016.10:g.68819299A>C	ExAC,TOPMed,gnomAD
rs776890776	p.Thr529Ala	missense variant	-	NC_000016.10:g.68819299A>G	ExAC,TOPMed,gnomAD
RCV000562109	p.Thr529Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819299A>G	ClinVar
RCV000165708	p.Thr529Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819299A>C	ClinVar
RCV000492449	p.Ala530Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819301dup	ClinVar
RCV000478712	p.Ala530Ter	frameshift	-	NC_000016.10:g.68819301dup	ClinVar
RCV000639222	p.Ala530Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819302G>C	ClinVar
rs1555516534	p.Ala530Pro	missense variant	-	NC_000016.10:g.68819302G>C	-
NCI-TCGA novel	p.Ala530Val	missense variant	-	NC_000016.10:g.68819303C>T	NCI-TCGA
RCV000520434	p.Asn531Ter	frameshift	-	NC_000016.10:g.68819304dup	ClinVar
rs765495095	p.Glu534Gly	missense variant	-	NC_000016.10:g.68819315A>G	ExAC,gnomAD
rs753031606	p.Glu534Asp	missense variant	-	NC_000016.10:g.68819316G>C	ExAC,gnomAD
RCV000487422	p.Ile535Phe	missense variant	-	NC_000016.10:g.68819317A>T	ClinVar
RCV000569091	p.Ile535Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819317A>C	ClinVar
RCV000571099	p.Ile535Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819317A>T	ClinVar
rs144519845	p.Ile535Leu	missense variant	-	NC_000016.10:g.68819317A>C	ESP,ExAC,TOPMed
rs144519845	p.Ile535Phe	missense variant	-	NC_000016.10:g.68819317A>T	ESP,ExAC,TOPMed
rs144519845	p.Ile535Val	missense variant	-	NC_000016.10:g.68819317A>G	ESP,ExAC,TOPMed
rs764282860	p.Asn536Asp	missense variant	-	NC_000016.10:g.68819320A>G	ExAC
RCV000160393	p.Pro537Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819324C>T	ClinVar
RCV000212373	p.Pro537Leu	missense variant	-	NC_000016.10:g.68819324C>T	ClinVar
RCV000234355	p.Pro537Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819324C>T	ClinVar
rs730881667	p.Pro537Leu	missense variant	-	NC_000016.10:g.68819324C>T	ExAC,TOPMed,gnomAD
RCV000679563	p.Asp538Tyr	missense variant	-	NC_000016.10:g.68819326G>T	ClinVar
RCV000573781	p.Asp538Tyr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819326G>T	ClinVar
RCV000504654	p.Asp538Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819326del	ClinVar
rs756154596	p.Asp538Tyr	missense variant	-	NC_000016.10:g.68819326G>T	ExAC,gnomAD
rs863224726	p.Asp538Val	missense variant	-	NC_000016.10:g.68819327A>T	-
RCV000198874	p.Asp538Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819327A>T	ClinVar
RCV000206314	p.Thr539Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819329A>G	ClinVar
rs864622070	p.Thr539Ala	missense variant	-	NC_000016.10:g.68819329A>G	-
rs730881668	p.Ala541Val	missense variant	-	NC_000016.10:g.68819336C>T	ExAC,gnomAD
RCV000160394	p.Ala541Val	missense variant	-	NC_000016.10:g.68819336C>T	ClinVar
RCV000562348	p.Ser543Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819342C>G	ClinVar
rs148400889	p.Ser543Phe	missense variant	-	NC_000016.10:g.68819342C>T	ESP,TOPMed,gnomAD
rs148400889	p.Ser543Cys	missense variant	-	NC_000016.10:g.68819342C>G	ESP,TOPMed,gnomAD
RCV000581941	p.Thr544Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819344A>G	ClinVar
rs786202107	p.Thr544Ala	missense variant	-	NC_000016.10:g.68819344A>G	-
rs786202107	p.Thr544Ser	missense variant	-	NC_000016.10:g.68819344A>T	-
RCV000164755	p.Thr544Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819344A>T	ClinVar
RCV000585989	p.Thr544Ala	missense variant	-	NC_000016.10:g.68819344A>G	ClinVar
RCV000195967	p.Arg545Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819347C>G	ClinVar
RCV000639204	p.Arg545Trp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819347C>T	ClinVar
RCV000515474	p.Arg545Trp	missense variant	Familial cancer of breast	NC_000016.10:g.68819347C>T	ClinVar
RCV000570962	p.Arg545Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819348G>A	ClinVar
RCV000792294	p.Arg545Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819348G>T	ClinVar
RCV000587960	p.Arg545Gln	missense variant	-	NC_000016.10:g.68819348G>A	ClinVar
RCV000809596	p.Arg545Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819348G>A	ClinVar
rs863224727	p.Arg545Gly	missense variant	-	NC_000016.10:g.68819347C>G	TOPMed,gnomAD
rs587780115	p.Arg545Leu	missense variant	-	NC_000016.10:g.68819348G>T	ExAC,gnomAD
RCV000221967	p.Arg545Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819347C>G	ClinVar
RCV000570878	p.Arg545Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819348G>T	ClinVar
rs863224727	p.Arg545Trp	missense variant	-	NC_000016.10:g.68819347C>T	TOPMed,gnomAD
rs587780115	p.Arg545Gln	missense variant	-	NC_000016.10:g.68819348G>A	ExAC,gnomAD
RCV000217485	p.Ala546Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819350G>A	ClinVar
RCV000569877	p.Ala546Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819350del	ClinVar
rs876658877	p.Ala546Thr	missense variant	-	NC_000016.10:g.68819350G>A	-
rs747801796	p.Leu548Pro	missense variant	-	NC_000016.10:g.68819357T>C	ExAC,gnomAD
RCV000534032	p.Leu548Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819356C>G	ClinVar
rs1181682630	p.Leu548Val	missense variant	-	NC_000016.10:g.68819356C>G	gnomAD
RCV000527221	p.Asp549Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819359G>A	ClinVar
rs876659525	p.Asp549Asn	missense variant	-	NC_000016.10:g.68819359G>A	-
RCV000219712	p.Asp549Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819359G>A	ClinVar
RCV000508188	p.Asp549Asn	missense variant	-	NC_000016.10:g.68819359G>A	ClinVar
RCV000774769	p.Arg550Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819363G>C	ClinVar
RCV000817071	p.Arg550Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819363G>C	ClinVar
rs771649648	p.Arg550Thr	missense variant	-	NC_000016.10:g.68819363G>C	ExAC,gnomAD
RCV000581637	p.Glu554Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819374G>A	ClinVar
rs566103420	p.Glu554Gln	missense variant	-	NC_000016.10:g.68819374G>C	1000Genomes,ExAC,gnomAD
rs566103420	p.Glu554Lys	missense variant	-	NC_000016.10:g.68819374G>A	1000Genomes,ExAC,gnomAD
RCV000688207	p.His555Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819377C>G	ClinVar
RCV000776668	p.His555Tyr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819377C>T	ClinVar
rs587782768	p.His555Asp	missense variant	-	NC_000016.10:g.68819377C>G	-
RCV000132296	p.His555Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819377C>G	ClinVar
RCV000566284	p.Val556Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819380G>A	ClinVar
RCV000214579	p.Val556Leu	missense variant	-	NC_000016.10:g.68819380G>C	ClinVar
rs876660399	p.Val556Leu	missense variant	-	NC_000016.10:g.68819380G>C	gnomAD
rs876660399	p.Val556Met	missense variant	-	NC_000016.10:g.68819380G>A	gnomAD
RCV000220412	p.Val556Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819380G>C	ClinVar
COSM972790	p.Lys557Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68819385G>T	NCI-TCGA Cosmic
rs1173188736	p.Lys557Arg	missense variant	-	NC_000016.10:g.68819384A>G	gnomAD
RCV000538831	p.Ser559Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819389A>T	ClinVar
COSM19513	p.Ser559Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68819390G>A	NCI-TCGA Cosmic
rs1555516566	p.Ser559Cys	missense variant	-	NC_000016.10:g.68819389A>T	-
RCV000167921	p.Thr560Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819393C>T	ClinVar
RCV000485776	p.Thr560Met	missense variant	-	NC_000016.10:g.68819393C>T	ClinVar
RCV000219965	p.Thr560Arg	missense variant	-	NC_000016.10:g.68819393C>G	ClinVar
RCV000215364	p.Thr560Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819393C>T	ClinVar
rs746481984	p.Thr560Arg	missense variant	-	NC_000016.10:g.68819393C>G	ExAC,TOPMed,gnomAD
rs746481984	p.Thr560Met	missense variant	-	NC_000016.10:g.68819393C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Thr560ArgPheSerTerUnk	frameshift	-	NC_000016.10:g.68819392A>-	NCI-TCGA
RCV000566595	p.Tyr561Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819393dup	ClinVar
rs918685758	p.Tyr561Cys	missense variant	-	NC_000016.10:g.68819396A>G	TOPMed
RCV000233909	p.Thr562Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819398A>G	ClinVar
RCV000549056	p.Thr562Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819398A>T	ClinVar
rs587782061	p.Thr562Ser	missense variant	-	NC_000016.10:g.68819398A>T	ExAC,TOPMed,gnomAD
rs587782381	p.Thr562Arg	missense variant	-	NC_000016.10:g.68819399C>G	-
rs587782061	p.Thr562Ala	missense variant	-	NC_000016.10:g.68819398A>G	ExAC,TOPMed,gnomAD
rs587782061	p.Thr562Pro	missense variant	-	NC_000016.10:g.68819398A>C	ExAC,TOPMed,gnomAD
RCV000791845	p.Thr562Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819399C>G	ClinVar
RCV000130507	p.Ala563Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819401G>T	ClinVar
RCV000568401	p.Ala563Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819401G>A	ClinVar
rs587782044	p.Ala563Ser	missense variant	-	NC_000016.10:g.68819401G>T	TOPMed
RCV000473796	p.Ala563Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819401G>T	ClinVar
RCV000212374	p.Ala563Ser	missense variant	-	NC_000016.10:g.68819401G>T	ClinVar
rs587782044	p.Ala563Thr	missense variant	-	NC_000016.10:g.68819401G>A	TOPMed
rs770201038	p.Leu564Gln	missense variant	-	NC_000016.10:g.68819405T>A	ExAC,gnomAD
rs786201342	p.Leu564Val	missense variant	-	NC_000016.10:g.68819404C>G	TOPMed,gnomAD
RCV000220447	p.Ile566Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819410A>C	ClinVar
RCV000218074	p.Ile566Thr	missense variant	-	NC_000016.10:g.68819411T>C	ClinVar
rs763292288	p.Ile566Thr	missense variant	-	NC_000016.10:g.68819411T>C	ExAC,gnomAD
RCV000206172	p.Ile566Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819411T>C	ClinVar
RCV000164574	p.Ile566Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819411T>C	ClinVar
rs775941240	p.Ile566Leu	missense variant	-	NC_000016.10:g.68819410A>C	ExAC,gnomAD
RCV000262178	p.Ala567Val	missense variant	-	NC_000016.10:g.68819414C>T	ClinVar
RCV000639258	p.Ala567Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819414C>T	ClinVar
rs886041160	p.Ala567Val	missense variant	-	NC_000016.10:g.68819414C>T	-
RCV000165660	p.Thr568Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819417C>T	ClinVar
RCV000492379	p.Thr568Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819417C>G	ClinVar
rs1060501242	p.Thr568Ala	missense variant	-	NC_000016.10:g.68819416A>G	-
RCV000473023	p.Thr568Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819416A>G	ClinVar
RCV000479771	p.Asp569Glu	missense variant	-	NC_000016.10:g.68819421C>A	ClinVar
rs876660905	p.Asp569Glu	missense variant	-	NC_000016.10:g.68819421C>A	gnomAD
RCV000216294	p.Asp569Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819421C>A	ClinVar
RCV000639281	p.Asn570Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68819423A>G	ClinVar
RCV000776909	p.Asn570His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819422A>C	ClinVar
rs1555516592	p.Asn570Ser	missense variant	-	NC_000016.10:g.68819423A>G	-
NCI-TCGA novel	p.Asn570MetPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68819422A>-	NCI-TCGA
rs786202290	p.Gly571Ser	missense variant	-	NC_000016.10:g.68819425G>A	-
RCV000165027	p.Gly571Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68819425G>A	ClinVar
RCV000542307	p.Pro573Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822007C>T	ClinVar
rs1555516819	p.Pro573Leu	missense variant	-	NC_000016.10:g.68822007C>T	-
rs767636524	p.Pro573Ser	missense variant	-	NC_000016.10:g.68822006C>T	ExAC,gnomAD
RCV000220657	p.Val574Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822009G>A	ClinVar
RCV000709397	p.Val574Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822010T>G	ClinVar
rs115934514	p.Val574Ile	missense variant	-	NC_000016.10:g.68822009G>A	1000Genomes,ExAC,gnomAD
rs115934514	p.Val574Phe	missense variant	-	NC_000016.10:g.68822009G>T	1000Genomes,ExAC,gnomAD
COSM5833149	p.Ala575GlyPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68822011_68822012insG	NCI-TCGA Cosmic
RCV000479921	p.Thr576Ala	missense variant	-	NC_000016.10:g.68822015A>G	ClinVar
RCV000568763	p.Thr576Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822015A>C	ClinVar
rs759536558	p.Thr576Ser	missense variant	-	NC_000016.10:g.68822015A>T	ExAC,gnomAD
RCV000566211	p.Thr576Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822015A>T	ClinVar
RCV000231721	p.Thr576Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822015A>T	ClinVar
rs759536558	p.Thr576Pro	missense variant	-	NC_000016.10:g.68822015A>C	ExAC,gnomAD
rs759536558	p.Thr576Ala	missense variant	-	NC_000016.10:g.68822015A>G	ExAC,gnomAD
RCV000565857	p.Gly577Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822019G>A	ClinVar
rs1555516820	p.Gly577Glu	missense variant	-	NC_000016.10:g.68822019G>A	-
RCV000706915	p.Thr578Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822022C>T	ClinVar
RCV000657274	p.Gly579Ter	frameshift	-	NC_000016.10:g.68822022dup	ClinVar
RCV000168151	p.Thr580Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822027A>G	ClinVar
rs786204155	p.Thr580Ala	missense variant	-	NC_000016.10:g.68822027A>G	-
RCV000771412	p.Leu581Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822030C>T	ClinVar
RCV000688984	p.Leu581Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822030C>T	ClinVar
RCV000639254	p.Leu582Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822033C>A	ClinVar
rs1801025	p.Leu582Met	missense variant	-	NC_000016.10:g.68822033C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000492101	p.Leu583Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822035dup	ClinVar
RCV000657176	p.Leu583Ter	frameshift	-	NC_000016.10:g.68822035dup	ClinVar
NCI-TCGA novel	p.Leu583ProPheSerTerUnk	frameshift	-	NC_000016.10:g.68822032_68822033insCTGC	NCI-TCGA
RCV000205226	p.Ser586Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822046C>T	ClinVar
rs864622599	p.Ser586Phe	missense variant	-	NC_000016.10:g.68822046C>T	TOPMed
rs1458799670	p.Asp587Val	missense variant	-	NC_000016.10:g.68822049A>T	gnomAD
NCI-TCGA novel	p.Asp587Ala	missense variant	-	NC_000016.10:g.68822049A>C	NCI-TCGA
rs1367108095	p.Asn589Ser	missense variant	-	NC_000016.10:g.68822055A>G	gnomAD
rs758238240	p.Asn589Asp	missense variant	-	NC_000016.10:g.68822054A>G	ExAC,gnomAD
RCV000206079	p.Asp590Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822059C>A	ClinVar
RCV000774770	p.Asp590Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822059C>A	ClinVar
rs864622319	p.Asp590Glu	missense variant	-	NC_000016.10:g.68822059C>A	TOPMed,gnomAD
NCI-TCGA novel	p.Asp590Asn	missense variant	-	NC_000016.10:g.68822057G>A	NCI-TCGA
rs1555516835	p.Asn591Ser	missense variant	-	NC_000016.10:g.68822061A>G	-
rs751291956	p.Asn591Asp	missense variant	-	NC_000016.10:g.68822060A>G	ExAC,gnomAD
RCV000639200	p.Asn591Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822061A>G	ClinVar
RCV000164679	p.Ala592Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822064C>G	ClinVar
rs786202059	p.Ala592Gly	missense variant	-	NC_000016.10:g.68822064C>G	-
RCV000765306	p.Ala592Ser	missense variant	Familial cancer of breast	NC_000016.10:g.68822063G>T	ClinVar
RCV000163911	p.Ala592Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822063G>T	ClinVar
RCV000034704	p.Ala592Thr	missense variant	-	NC_000016.10:g.68822063G>A	ClinVar
rs35187787	p.Ala592Ser	missense variant	-	NC_000016.10:g.68822063G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000552810	p.Ala592Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822063G>T	ClinVar
RCV000148453	p.Ala592Thr	missense variant	Neoplasm of the breast	NC_000016.10:g.68822063G>A	ClinVar
RCV000480077	p.Ala592Ser	missense variant	-	NC_000016.10:g.68822063G>T	ClinVar
rs35187787	p.Ala592Thr	missense variant	-	NC_000016.10:g.68822063G>A	UniProt,dbSNP
VAR_001318	p.Ala592Thr	missense variant	-	NC_000016.10:g.68822063G>A	UniProt
rs35187787	p.Ala592Thr	missense variant	-	NC_000016.10:g.68822063G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000776801	p.Pro593Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822067C>G	ClinVar
RCV000222914	p.Ile594Ter	frameshift	-	NC_000016.10:g.68822068dup	ClinVar
RCV000562579	p.Ile594Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822069A>T	ClinVar
RCV000639247	p.Ile594Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822069A>T	ClinVar
rs1206609823	p.Ile594Leu	missense variant	-	NC_000016.10:g.68822069A>T	TOPMed
RCV000492623	p.Ile594Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822068dup	ClinVar
RCV000570513	p.Pro595Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822072C>T	ClinVar
RCV000695512	p.Pro595Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822073C>G	ClinVar
RCV000581283	p.Pro595Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822073C>G	ClinVar
rs1555516843	p.Pro595Arg	missense variant	-	NC_000016.10:g.68822073C>G	-
RCV000541565	p.Pro595Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822072C>T	ClinVar
rs755622441	p.Pro595Ser	missense variant	-	NC_000016.10:g.68822072C>T	ExAC,TOPMed,gnomAD
RCV000687357	p.Glu596Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822075G>A	ClinVar
RCV000556249	p.Glu596Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822075G>C	ClinVar
rs1555516844	p.Glu596Gln	missense variant	-	NC_000016.10:g.68822075G>C	-
RCV000575345	p.Pro597Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822078C>T	ClinVar
RCV000166250	p.Pro597Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822078C>A	ClinVar
RCV000506747	p.Pro597Thr	missense variant	-	NC_000016.10:g.68822078C>A	ClinVar
RCV000707611	p.Pro597Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822078C>T	ClinVar
rs201625049	p.Pro597Ser	missense variant	-	NC_000016.10:g.68822078C>T	TOPMed
RCV000034705	p.Pro597Ser	missense variant	-	NC_000016.10:g.68822078C>T	ClinVar
rs201625049	p.Pro597Thr	missense variant	-	NC_000016.10:g.68822078C>A	TOPMed
NCI-TCGA novel	p.Pro597GluPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68822074_68822099AGAACCTCGAACTATATTCTTCTGTG>-	NCI-TCGA
RCV000013028	p.Arg598Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822081C>T	ClinVar
rs780759537	p.Arg598Gln	missense variant	-	NC_000016.10:g.68822082G>A	ExAC,gnomAD
RCV000168156	p.Arg598Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822082G>A	ClinVar
RCV000216786	p.Arg598Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822082G>A	ClinVar
RCV000470902	p.Arg598Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822081C>G	ClinVar
RCV000484230	p.Arg598Ter	nonsense	-	NC_000016.10:g.68822081C>T	ClinVar
RCV000213248	p.Arg598Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822081C>T	ClinVar
rs121964877	p.Arg598Ter	stop gained	-	NC_000016.10:g.68822081C>T	-
RCV000466849	p.Thr599Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822085C>T	ClinVar
rs377302798	p.Thr599Ser	missense variant	-	NC_000016.10:g.68822085C>G	ESP,TOPMed,gnomAD
RCV000220982	p.Thr599Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822085C>T	ClinVar
rs377302798	p.Thr599Ile	missense variant	-	NC_000016.10:g.68822085C>T	ESP,TOPMed,gnomAD
RCV000228422	p.Ile600Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822089A>G	ClinVar
rs878854680	p.Ile600Met	missense variant	-	NC_000016.10:g.68822089A>G	gnomAD
rs1044050273	p.Ile600Thr	missense variant	-	NC_000016.10:g.68822088T>C	TOPMed
NCI-TCGA novel	p.Phe602GlnPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68822071_68822072insCCAGAACCTCGAACTATATT	NCI-TCGA
rs864622612	p.Cys603Ser	missense variant	-	NC_000016.10:g.68822097G>C	-
RCV000204502	p.Cys603Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822097G>C	ClinVar
rs864622612	p.Cys603Tyr	missense variant	-	NC_000016.10:g.68822097G>A	-
RCV000568473	p.Cys603Tyr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822097G>A	ClinVar
COSM972794	p.Asn606Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68822106A>T	NCI-TCGA Cosmic
COSM1479029	p.Pro607Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68822108C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Lys608Asn	missense variant	-	NC_000016.10:g.68822113G>T	NCI-TCGA
RCV000777385	p.Pro609Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822114C>T	ClinVar
rs1555516856	p.Gln610Pro	missense variant	-	NC_000016.10:g.68822118A>C	-
RCV000586427	p.Gln610Pro	missense variant	-	NC_000016.10:g.68822118A>C	ClinVar
rs779351070	p.Val611Asp	missense variant	-	NC_000016.10:g.68822121T>A	ExAC,gnomAD
RCV000221471	p.Val611Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822121T>A	ClinVar
RCV000166050	p.Ile612Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822123A>G	ClinVar
RCV000529171	p.Ile612Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822123A>G	ClinVar
rs786202965	p.Ile612Val	missense variant	-	NC_000016.10:g.68822123A>G	-
RCV000571536	p.Asn613Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822127A>G	ClinVar
rs1555516860	p.Asn613Ser	missense variant	-	NC_000016.10:g.68822127A>G	-
RCV000701176	p.Ile614Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822129A>G	ClinVar
rs587782838	p.Ile614Phe	missense variant	-	NC_000016.10:g.68822129A>T	ExAC,gnomAD
rs587782838	p.Ile614Val	missense variant	-	NC_000016.10:g.68822129A>G	ExAC,gnomAD
RCV000214623	p.Ile614Val	missense variant	-	NC_000016.10:g.68822129A>G	ClinVar
RCV000132427	p.Ile614Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822129A>G	ClinVar
RCV000701413	p.Ile615Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822132A>G	ClinVar
RCV000554381	p.Ile615Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822133T>C	ClinVar
RCV000484607	p.Ile615Thr	missense variant	-	NC_000016.10:g.68822133T>C	ClinVar
RCV000219158	p.Ile615Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822133T>C	ClinVar
RCV000765307	p.Ile615Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822132A>G	ClinVar
rs1003012321	p.Ile615Val	missense variant	-	NC_000016.10:g.68822132A>G	TOPMed,gnomAD
RCV000566335	p.Ile615Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822132A>G	ClinVar
rs760707493	p.Ile615Thr	missense variant	-	NC_000016.10:g.68822133T>C	ExAC,TOPMed,gnomAD
rs33935154	p.Ala617Ser	missense variant	-	NC_000016.10:g.68822138G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000130292	p.Ala617Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822138G>A	ClinVar
RCV000561868	p.Ala617Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822138G>T	ClinVar
RCV000532668	p.Ala617Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822138G>T	ClinVar
rs33935154	p.Ala617Thr	missense variant	-	NC_000016.10:g.68822138G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs33935154	p.Ala617Thr	missense variant	-	NC_000016.10:g.68822138G>A	UniProt,dbSNP
VAR_001320	p.Ala617Thr	missense variant	-	NC_000016.10:g.68822138G>A	UniProt
RCV000220007	p.Leu619Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822144C>T	ClinVar
rs876659221	p.Leu619Phe	missense variant	-	NC_000016.10:g.68822144C>T	gnomAD
RCV000164399	p.Pro620Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822147C>A	ClinVar
RCV000473475	p.Pro620Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822147C>A	ClinVar
RCV000164881	p.Pro620Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822147C>T	ClinVar
RCV000543150	p.Pro620Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822148C>T	ClinVar
rs786201888	p.Pro620Ser	missense variant	-	NC_000016.10:g.68822147C>T	-
rs1555516871	p.Pro620Leu	missense variant	-	NC_000016.10:g.68822148C>T	-
rs786201888	p.Pro620Thr	missense variant	-	NC_000016.10:g.68822147C>A	-
RCV000131244	p.Asn622Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822154A>G	ClinVar
RCV000761008	p.Asn622Ser	missense variant	B Lymphoblastic Leukemia/Lymphoma	NC_000016.10:g.68822154A>G	ClinVar
rs367849039	p.Asn622Tyr	missense variant	-	NC_000016.10:g.68822153A>T	ESP,ExAC,TOPMed,gnomAD
RCV000160395	p.Asn622His	missense variant	-	NC_000016.10:g.68822153A>C	ClinVar
RCV000286705	p.Asn622Ser	missense variant	-	NC_000016.10:g.68822154A>G	ClinVar
RCV000123241	p.Asn622Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822154A>G	ClinVar
rs367849039	p.Asn622His	missense variant	-	NC_000016.10:g.68822153A>C	ESP,ExAC,TOPMed,gnomAD
rs147925149	p.Asn622Ser	missense variant	-	NC_000016.10:g.68822154A>G	ESP,ExAC,TOPMed,gnomAD
RCV000574184	p.Pro625Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822162C>G	ClinVar
rs1555516877	p.Pro625Ala	missense variant	-	NC_000016.10:g.68822162C>G	-
RCV000456373	p.Phe626Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822165T>G	ClinVar
RCV000215202	p.Phe626Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822165T>G	ClinVar
rs876660603	p.Phe626Val	missense variant	-	NC_000016.10:g.68822165T>G	TOPMed
COSM1479030	p.Thr627HisPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68822164_68822165insT	NCI-TCGA Cosmic
RCV000584235	p.Thr627Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822168A>C	ClinVar
rs751265976	p.Thr627Arg	missense variant	-	NC_000016.10:g.68822169C>G	ExAC
rs1555516886	p.Thr627Pro	missense variant	-	NC_000016.10:g.68822168A>C	-
RCV000689849	p.Glu629Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822174G>C	ClinVar
RCV000573799	p.Glu629Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822174G>C	ClinVar
rs1028765743	p.Glu629Gln	missense variant	-	NC_000016.10:g.68822174G>C	TOPMed,gnomAD
rs2276331	p.Leu630Val	missense variant	-	NC_000016.10:g.68822177C>G	1000Genomes,ExAC,TOPMed,gnomAD
RCV000563149	p.Leu630Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822178T>C	ClinVar
RCV000195597	p.Leu630Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822177C>G	ClinVar
rs767116004	p.Leu630Pro	missense variant	-	NC_000016.10:g.68822178T>C	ExAC,gnomAD
rs767116004	p.Leu630Gln	missense variant	-	NC_000016.10:g.68822178T>A	ExAC,gnomAD
RCV000508276	p.His632Arg	missense variant	-	NC_000016.10:g.68822184A>G	ClinVar
rs1555516892	p.His632Arg	missense variant	-	NC_000016.10:g.68822184A>G	-
RCV000468989	p.His632Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822180_68822181AC[2]	ClinVar
NCI-TCGA novel	p.His632GlnPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68822185C>-	NCI-TCGA
RCV000129704	p.Gly633Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822186G>A	ClinVar
RCV000132448	p.Gly633Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822187G>A	ClinVar
rs587782850	p.Gly633Glu	missense variant	-	NC_000016.10:g.68822187G>A	-
rs587781615	p.Gly633Arg	missense variant	-	NC_000016.10:g.68822186G>A	ExAC,gnomAD
rs587781615	p.Gly633Trp	missense variant	-	NC_000016.10:g.68822186G>T	ExAC,gnomAD
RCV000792280	p.Gly633Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822186G>A	ClinVar
RCV000472963	p.Ala634Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822189G>A	ClinVar
RCV000485862	p.Ala634Thr	missense variant	-	NC_000016.10:g.68822189G>A	ClinVar
RCV000013031	p.Ala634Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822190C>T	ClinVar
rs1060501240	p.Ala634Thr	missense variant	-	NC_000016.10:g.68822189G>A	-
rs121964878	p.Ala634Val	missense variant	-	NC_000016.10:g.68822190C>T	-
rs121964878	p.Ala634Val	missense variant	-	NC_000016.10:g.68822190C>T	UniProt,dbSNP
VAR_055431	p.Ala634Val	missense variant	-	NC_000016.10:g.68822190C>T	UniProt
RCV000571740	p.Ser635Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822192A>G	ClinVar
rs1318805721	p.Ser635Gly	missense variant	-	NC_000016.10:g.68822192A>G	gnomAD
NCI-TCGA novel	p.Ser635Ile	missense variant	-	NC_000016.10:g.68822193G>T	NCI-TCGA
RCV000693174	p.Ala636Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822195G>A	ClinVar
RCV000221626	p.Ala636Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822195G>A	ClinVar
RCV000639220	p.Ala636Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822196C>T	ClinVar
rs1555516894	p.Ala636Val	missense variant	-	NC_000016.10:g.68822196C>T	-
rs876658950	p.Ala636Thr	missense variant	-	NC_000016.10:g.68822195G>A	TOPMed,gnomAD
rs755482251	p.Asn637Ser	missense variant	-	NC_000016.10:g.68822199A>G	ExAC,gnomAD
RCV000736284	p.Trp638Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822202G>A	ClinVar
RCV000564925	p.Thr639Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822204A>G	ClinVar
RCV000695428	p.Thr639Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822204A>G	ClinVar
rs1555516895	p.Thr639Ala	missense variant	-	NC_000016.10:g.68822204A>G	-
RCV000639279	p.Ile640Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822206_68822207del	ClinVar
RCV000696378	p.Gln641Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822211A>G	ClinVar
RCV000214635	p.Gln641Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822211A>G	ClinVar
RCV000662630	p.Gln641Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822210C>T	ClinVar
rs587782750	p.Gln641Ter	stop gained	-	NC_000016.10:g.68822210C>T	ExAC,gnomAD
rs876660113	p.Gln641Arg	missense variant	-	NC_000016.10:g.68822211A>G	-
RCV000486533	p.Gln641Arg	missense variant	-	NC_000016.10:g.68822211A>G	ClinVar
RCV000129550	p.Asn643Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822216A>G	ClinVar
RCV000771398	p.Asn643Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822217A>G	ClinVar
RCV000574637	p.Asn643Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822218C>A	ClinVar
rs374152504	p.Asn643Lys	missense variant	-	NC_000016.10:g.68822218C>A	ESP,ExAC,TOPMed,gnomAD
rs587781540	p.Asn643Asp	missense variant	-	NC_000016.10:g.68822216A>G	-
RCV000129863	p.Asp644Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822219G>A	ClinVar
rs587781696	p.Asp644His	missense variant	-	NC_000016.10:g.68822219G>C	ExAC,TOPMed,gnomAD
rs587781696	p.Asp644Asn	missense variant	-	NC_000016.10:g.68822219G>A	ExAC,TOPMed,gnomAD
RCV000231981	p.Asp644Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68822219G>A	ClinVar
RCV000588229	p.Asp644Asn	missense variant	-	NC_000016.10:g.68822219G>A	ClinVar
rs747240698	p.Pro645Ser	missense variant	-	NC_000016.10:g.68822222C>T	ExAC,gnomAD
rs1331707958	p.Thr646Asn	missense variant	-	NC_000016.10:g.68823399C>A	gnomAD
RCV000571504	p.Thr646Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68822225A>G	ClinVar
rs771064558	p.Thr646Ala	missense variant	-	NC_000016.10:g.68822225A>G	ExAC,gnomAD
rs778195664	p.Gln647Glu	missense variant	-	NC_000016.10:g.68823401C>G	ExAC
NCI-TCGA novel	p.Gln647Leu	missense variant	-	NC_000016.10:g.68823402A>T	NCI-TCGA
NCI-TCGA novel	p.Gln647Ter	stop gained	-	NC_000016.10:g.68823401C>T	NCI-TCGA
RCV000478373	p.Glu648Gln	missense variant	-	NC_000016.10:g.68823404G>C	ClinVar
rs971882211	p.Glu648Ter	stop gained	-	NC_000016.10:g.68823404G>T	TOPMed,gnomAD
RCV000639224	p.Glu648Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823404G>C	ClinVar
RCV000536569	p.Glu648Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823404G>T	ClinVar
rs971882211	p.Glu648Gln	missense variant	-	NC_000016.10:g.68823404G>C	TOPMed,gnomAD
RCV000562356	p.Ser649Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823408C>T	ClinVar
RCV000525333	p.Ser649Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823408C>T	ClinVar
rs1238607560	p.Ser649Phe	missense variant	-	NC_000016.10:g.68823408C>T	gnomAD
RCV000478403	p.Ile650Thr	missense variant	-	NC_000016.10:g.68823411T>C	ClinVar
RCV000780091	p.Ile650Thr	missense variant	-	NC_000016.10:g.68823411T>C	ClinVar
RCV000535633	p.Ile650Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823410A>G	ClinVar
COSM1479033	p.Ile650TyrPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68823408_68823409insT	NCI-TCGA Cosmic
RCV000165892	p.Ile650Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823411T>C	ClinVar
RCV000550538	p.Ile650Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823411T>C	ClinVar
RCV000561883	p.Ile650Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823410_68823411del	ClinVar
rs1555517077	p.Ile650Val	missense variant	-	NC_000016.10:g.68823410A>G	-
rs747235838	p.Ile650Thr	missense variant	-	NC_000016.10:g.68823411T>C	ExAC,gnomAD
RCV000570006	p.Ile651Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823415T>G	ClinVar
RCV000551453	p.Ile651Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823410_68823411dup	ClinVar
RCV000571180	p.Ile651Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823414T>C	ClinVar
rs876660503	p.Ile651Val	missense variant	-	NC_000016.10:g.68823413A>G	-
rs1555517080	p.Ile651Thr	missense variant	-	NC_000016.10:g.68823414T>C	-
rs1555517083	p.Ile651Met	missense variant	-	NC_000016.10:g.68823415T>G	-
RCV000217003	p.Ile651Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823413A>G	ClinVar
RCV000528946	p.Ile651Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823413A>G	ClinVar
RCV000761061	p.Leu652Trp	missense variant	Acute myeloid leukemia (AML)	NC_000016.10:g.68823417T>G	ClinVar
rs1555517084	p.Lys653Thr	missense variant	-	NC_000016.10:g.68823420A>C	-
RCV000521821	p.Lys653Thr	missense variant	-	NC_000016.10:g.68823420A>C	ClinVar
NCI-TCGA novel	p.Met656Ter	frameshift	-	NC_000016.10:g.68823428_68823434ATGGCCT>-	NCI-TCGA
rs757422353	p.Ala657Gly	missense variant	-	NC_000016.10:g.68823432C>G	ExAC,gnomAD
RCV000213110	p.Glu659Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823439G>T	ClinVar
rs368243190	p.Glu659Asp	missense variant	-	NC_000016.10:g.68823439G>T	ESP,ExAC,TOPMed,gnomAD
rs781280931	p.Glu659Lys	missense variant	-	NC_000016.10:g.68823437G>A	ExAC,gnomAD
RCV000539244	p.Val660Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823440G>A	ClinVar
rs1555517090	p.Val660Glu	missense variant	-	NC_000016.10:g.68823441T>A	-
RCV000573208	p.Val660Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823441T>C	ClinVar
RCV000568800	p.Val660Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823440G>A	ClinVar
RCV000820444	p.Val660Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823441T>C	ClinVar
RCV000568722	p.Val660Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823441T>A	ClinVar
rs769844369	p.Val660Met	missense variant	-	NC_000016.10:g.68823440G>A	ExAC,gnomAD
rs1555517090	p.Val660Ala	missense variant	-	NC_000016.10:g.68823441T>C	-
RCV000160368	p.Gly661Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823441dup	ClinVar
rs756092625	p.Gly661Asp	missense variant	-	NC_000016.10:g.68823444G>A	ExAC
RCV000197868	p.Tyr663Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823450A>G	ClinVar
RCV000212376	p.Tyr663Cys	missense variant	-	NC_000016.10:g.68823450A>G	ClinVar
RCV000129549	p.Tyr663Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823450A>G	ClinVar
RCV000766709	p.Tyr663Cys	missense variant	-	NC_000016.10:g.68823450A>G	ClinVar
rs372182377	p.Tyr663Cys	missense variant	-	NC_000016.10:g.68823450A>G	ESP,TOPMed,gnomAD
NCI-TCGA novel	p.Tyr663Phe	missense variant	-	NC_000016.10:g.68823450A>T	NCI-TCGA
RCV000569362	p.Lys664Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823453A>G	ClinVar
rs1436479908	p.Lys664Arg	missense variant	-	NC_000016.10:g.68823453A>G	gnomAD
rs1275496047	p.Lys664Gln	missense variant	-	NC_000016.10:g.68823452A>C	gnomAD
RCV000205339	p.Ile665Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823455A>G	ClinVar
RCV000694737	p.Ile665Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823455del	ClinVar
COSM5029231	p.Ile665SerPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68823452A>-	NCI-TCGA Cosmic
rs864622503	p.Ile665Val	missense variant	-	NC_000016.10:g.68823455A>G	-
RCV000206535	p.Asn666His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823458A>C	ClinVar
rs897830106	p.Asn666Ser	missense variant	-	NC_000016.10:g.68823459A>G	-
rs1167042883	p.Asn666Lys	missense variant	-	NC_000016.10:g.68823460T>G	TOPMed
RCV000165090	p.Asn666His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823458A>C	ClinVar
RCV000679568	p.Asn666His	missense variant	-	NC_000016.10:g.68823458A>C	ClinVar
rs150427791	p.Asn666His	missense variant	-	NC_000016.10:g.68823458A>C	ESP,ExAC,TOPMed,gnomAD
RCV000810597	p.Leu667Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823461del	ClinVar
RCV000164640	p.Leu667Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823461del	ClinVar
RCV000699936	p.Leu667Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823461C>T	ClinVar
RCV000376724	p.Leu667Ter	frameshift	-	NC_000016.10:g.68823461del	ClinVar
COSM1479034	p.Lys668Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68823464A>T	NCI-TCGA Cosmic
RCV000705015	p.Leu669Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823467C>T	ClinVar
RCV000639214	p.Leu669Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823467C>G	ClinVar
RCV000701262	p.Leu669Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823467C>A	ClinVar
rs1490366214	p.Leu669Val	missense variant	-	NC_000016.10:g.68823467C>G	gnomAD
rs1490366214	p.Leu669Phe	missense variant	-	NC_000016.10:g.68823467C>T	gnomAD
RCV000467277	p.Met670Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823470A>G	ClinVar
RCV000214785	p.Met670Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823471T>C	ClinVar
rs773006015	p.Met670Thr	missense variant	-	NC_000016.10:g.68823471T>C	ExAC,TOPMed,gnomAD
RCV000808326	p.Met670Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823471T>C	ClinVar
rs876660107	p.Met670Val	missense variant	-	NC_000016.10:g.68823470A>G	gnomAD
RCV000220503	p.Met670Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823470A>G	ClinVar
RCV000481368	p.Met670Val	missense variant	-	NC_000016.10:g.68823470A>G	ClinVar
RCV000459635	p.Gln673Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823479C>A	ClinVar
RCV000212377	p.Gln673Lys	missense variant	-	NC_000016.10:g.68823479C>A	ClinVar
RCV000589626	p.Gln673Lys	missense variant	-	NC_000016.10:g.68823479C>A	ClinVar
RCV000129870	p.Gln673Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823479C>A	ClinVar
COSM5563880	p.Gln673Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68823479C>T	NCI-TCGA Cosmic
rs587781701	p.Gln673Lys	missense variant	-	NC_000016.10:g.68823479C>A	ExAC,gnomAD
rs201637081	p.Asn674Tyr	missense variant	-	NC_000016.10:g.68823482A>T	ExAC,TOPMed,gnomAD
RCV000131485	p.Asn674Tyr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823482A>T	ClinVar
rs876660230	p.Lys675Arg	missense variant	-	NC_000016.10:g.68823486A>G	-
RCV000214763	p.Lys675Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823486A>G	ClinVar
RCV000807275	p.Lys675Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823486A>G	ClinVar
rs115408226	p.Asp676Asn	missense variant	-	NC_000016.10:g.68823488G>A	1000Genomes,ExAC,TOPMed,gnomAD
RCV000505788	p.Asp676Glu	missense variant	Ectropion inferior cleft lip and or palate (BCDS1)	NC_000016.10:g.68823490C>A	ClinVar
rs1555517099	p.Asp676Glu	missense variant	-	NC_000016.10:g.68823490C>A	-
rs115408226	p.Asp676Tyr	missense variant	-	NC_000016.10:g.68823488G>T	1000Genomes,ExAC,TOPMed,gnomAD
RCV000160396	p.Asp676Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823488G>A	ClinVar
RCV000212379	p.Asp676Asn	missense variant	-	NC_000016.10:g.68823488G>A	ClinVar
RCV000168234	p.Asp676Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823488G>A	ClinVar
RCV000566615	p.Gln677Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823491dup	ClinVar
RCV000218033	p.Val678Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823495T>C	ClinVar
rs764788846	p.Val678Leu	missense variant	-	NC_000016.10:g.68823494G>C	ExAC,gnomAD
rs876659352	p.Val678Ala	missense variant	-	NC_000016.10:g.68823495T>C	-
COSM1479035	p.Thr679AspPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68823494_68823495insT	NCI-TCGA Cosmic
RCV000213812	p.Thr680Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823500A>G	ClinVar
RCV000460790	p.Thr680Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823500A>G	ClinVar
rs876658936	p.Thr680Ala	missense variant	-	NC_000016.10:g.68823500A>G	-
rs758872535	p.Val683Ile	missense variant	-	NC_000016.10:g.68823509G>A	ExAC,gnomAD
RCV000553035	p.Ser684Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823512A>G	ClinVar
rs1407001897	p.Ser684Gly	missense variant	-	NC_000016.10:g.68823512A>G	gnomAD
RCV000703993	p.Val685Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823515G>C	ClinVar
RCV000120501	p.Val685Met	missense variant	-	NC_000016.10:g.68823515G>A	ClinVar
rs550612843	p.Val685Met	missense variant	-	NC_000016.10:g.68823515G>A	1000Genomes,ExAC,TOPMed,gnomAD
RCV000215976	p.Val685Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823515G>C	ClinVar
rs550612843	p.Val685Leu	missense variant	-	NC_000016.10:g.68823515G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs1555517113	p.Cys686Gly	missense variant	-	NC_000016.10:g.68823518T>G	-
RCV000579846	p.Cys686Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823518T>G	ClinVar
rs1401120990	p.Cys686Tyr	missense variant	-	NC_000016.10:g.68823519G>A	gnomAD
NCI-TCGA novel	p.Cys686Arg	missense variant	-	NC_000016.10:g.68823518T>C	NCI-TCGA
NCI-TCGA novel	p.Asp687Asn	missense variant	-	NC_000016.10:g.68823521G>A	NCI-TCGA
NCI-TCGA novel	p.Asp687His	missense variant	-	NC_000016.10:g.68823521G>C	NCI-TCGA
RCV000507739	p.Cys688Ter	nonsense	-	NC_000016.10:g.68823524_68823525TG[1]	ClinVar
RCV000128928	p.Cys688Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823524_68823525TG[1]	ClinVar
RCV000168178	p.Cys688Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823524_68823525TG[1]	ClinVar
rs587781276	p.CysGlu688Ter	stop gained	-	NC_000016.10:g.68823526_68823527del	TOPMed
rs1272471005	p.Gly690Glu	missense variant	-	NC_000016.10:g.68823531G>A	gnomAD
RCV000225820	p.Ala691Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823533G>A	ClinVar
RCV000574645	p.Ala691Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823534C>A	ClinVar
rs876660560	p.Ala691Thr	missense variant	-	NC_000016.10:g.68823533G>A	TOPMed,gnomAD
rs569086883	p.Ala691Asp	missense variant	-	NC_000016.10:g.68823534C>A	1000Genomes,ExAC,TOPMed,gnomAD
RCV000216757	p.Ala691Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823533G>A	ClinVar
RCV000522062	p.Ala691Asp	missense variant	-	NC_000016.10:g.68823534C>A	ClinVar
RCV000541735	p.Ala691Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823534C>A	ClinVar
rs1064794090	p.Ala692Thr	missense variant	-	NC_000016.10:g.68823536_68823538delinsACC	-
RCV000120502	p.Ala692Thr	missense variant	-	NC_000016.10:g.68823536G>A	ClinVar
rs376854556	p.Ala692Thr	missense variant	-	NC_000016.10:g.68823536G>A	ESP,ExAC,TOPMed,gnomAD
rs376854556	p.Ala692Ser	missense variant	-	NC_000016.10:g.68823536G>T	ESP,ExAC,TOPMed,gnomAD
RCV000478155	p.Ala692Thr	missense variant	-	NC_000016.10:g.68823536_68823538delinsACC	ClinVar
RCV000221412	p.Gly693Ter	frameshift	-	NC_000016.10:g.68823538_68823539del	ClinVar
rs386833398	p.Gly693Ser	missense variant	-	NC_000016.10:g.68823539G>A	ExAC,TOPMed,gnomAD
RCV000129247	p.Gly693Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823539G>A	ClinVar
rs587780118	p.Val694Ile	missense variant	-	NC_000016.10:g.68823542G>A	gnomAD
RCV000222804	p.Val694Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823542G>A	ClinVar
RCV000580064	p.Lys697Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823551A>G	ClinVar
rs1555517126	p.Lys697Glu	missense variant	-	NC_000016.10:g.68823551A>G	-
RCV000483072	p.Ala698Val	missense variant	-	NC_000016.10:g.68823555C>T	ClinVar
RCV000771206	p.Ala698Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823554G>C	ClinVar
rs1167040681	p.Ala698Thr	missense variant	-	NC_000016.10:g.68823554G>A	gnomAD
RCV000811072	p.Ala698Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823555C>T	ClinVar
rs1064795359	p.Ala698Val	missense variant	-	NC_000016.10:g.68823555C>T	-
rs1167040681	p.Ala698Ser	missense variant	-	NC_000016.10:g.68823554G>T	gnomAD
RCV000013024	p.Gln699Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823557C>T	ClinVar
RCV000132483	p.Gln699Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823557C>G	ClinVar
rs121964874	p.Gln699Glu	missense variant	-	NC_000016.10:g.68823557C>G	ExAC,gnomAD
rs121964874	p.Gln699Ter	stop gained	-	NC_000016.10:g.68823557C>T	ExAC,gnomAD
rs121964874	p.Gln699Lys	missense variant	-	NC_000016.10:g.68823557C>A	ExAC,gnomAD
RCV000569207	p.Pro700Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823560C>A	ClinVar
RCV000470718	p.Pro700Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823560C>A	ClinVar
RCV000229798	p.Pro700Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823560C>G	ClinVar
rs878854681	p.Pro700Thr	missense variant	-	NC_000016.10:g.68823560C>A	TOPMed,gnomAD
rs878854681	p.Pro700Ala	missense variant	-	NC_000016.10:g.68823560C>G	TOPMed,gnomAD
RCV000583312	p.Val701Ter	frameshift	-	NC_000016.10:g.68823562del	ClinVar
rs1426734014	p.Val701Leu	missense variant	-	NC_000016.10:g.68823563G>C	gnomAD
rs1426734014	p.Val701Ile	missense variant	-	NC_000016.10:g.68823563G>A	gnomAD
RCV000639209	p.Val701Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823562del	ClinVar
RCV000566347	p.Val701Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823563G>A	ClinVar
rs1426734014	p.Val701Phe	missense variant	-	NC_000016.10:g.68823563G>T	gnomAD
RCV000561482	p.Glu702Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823566G>C	ClinVar
RCV000480639	p.Glu702Gln	missense variant	-	NC_000016.10:g.68823566G>C	ClinVar
RCV000588944	p.Glu702Lys	missense variant	-	NC_000016.10:g.68823566G>A	ClinVar
RCV000530851	p.Glu702Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823566G>T	ClinVar
RCV000695360	p.Glu702Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823566G>C	ClinVar
rs149127230	p.Glu702Gln	missense variant	-	NC_000016.10:g.68823566G>C	ESP,ExAC,TOPMed,gnomAD
rs149127230	p.Glu702Lys	missense variant	-	NC_000016.10:g.68823566G>A	ESP,ExAC,TOPMed,gnomAD
rs149127230	p.Glu702Ter	stop gained	-	NC_000016.10:g.68823566G>T	ESP,ExAC,TOPMed,gnomAD
RCV000222037	p.Ala703Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823570C>T	ClinVar
rs876658987	p.Ala703Val	missense variant	-	NC_000016.10:g.68823570C>T	-
RCV000704119	p.Gly704Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823572G>A	ClinVar
rs759256066	p.Leu705Phe	missense variant	-	NC_000016.10:g.68823577G>T	ExAC,TOPMed,gnomAD
RCV000129251	p.Gln706Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823579A>G	ClinVar
RCV000639231	p.Gln706Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823579A>G	ClinVar
rs587781401	p.Gln706Arg	missense variant	-	NC_000016.10:g.68823579A>G	-
RCV000471426	p.Pro708Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823584C>A	ClinVar
COSM435607	p.Pro708LeuPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68823582T>-	NCI-TCGA Cosmic
rs1060501233	p.Pro708Thr	missense variant	-	NC_000016.10:g.68823584C>A	-
rs138101372	p.Ala709Ser	missense variant	-	NC_000016.10:g.68823587G>T	ESP,ExAC,gnomAD
rs876660625	p.Ile710Leu	missense variant	-	NC_000016.10:g.68823590A>C	gnomAD
rs876660625	p.Ile710Val	missense variant	-	NC_000016.10:g.68823590A>G	gnomAD
RCV000219281	p.Ile710Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823590A>C	ClinVar
RCV000130551	p.Leu711Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823593C>G	ClinVar
RCV000382368	p.Leu711Val	missense variant	-	NC_000016.10:g.68823593C>G	ClinVar
RCV000196099	p.Leu711Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823593C>G	ClinVar
rs121964871	p.Leu711Val	missense variant	-	NC_000016.10:g.68823593C>G	UniProt,dbSNP
VAR_001321	p.Leu711Val	missense variant	-	NC_000016.10:g.68823593C>G	UniProt
rs121964871	p.Leu711Val	missense variant	-	NC_000016.10:g.68823593C>G	TOPMed,gnomAD
rs1385460487	p.Gly712Val	missense variant	-	NC_000016.10:g.68823597G>T	gnomAD
RCV000580740	p.Ile713Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823599A>T	ClinVar
RCV000777552	p.Ile713Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823600T>C	ClinVar
rs1289236005	p.Ile713Phe	missense variant	-	NC_000016.10:g.68823599A>T	gnomAD
RCV000584408	p.Gly715Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823606del	ClinVar
rs1358094794	p.Gly715Glu	missense variant	-	NC_000016.10:g.68823606G>A	gnomAD
RCV000561368	p.Ile717Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823613T>G	ClinVar
rs1205147360	p.Ile717Met	missense variant	-	NC_000016.10:g.68823613T>G	gnomAD
RCV000214616	p.Leu718Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68823614C>G	ClinVar
rs876658591	p.Leu718Ile	missense variant	-	NC_000016.10:g.68823614C>A	TOPMed,gnomAD
RCV000213313	p.Leu718Ile	missense variant	-	NC_000016.10:g.68823614C>A	ClinVar
rs876658591	p.Leu718Val	missense variant	-	NC_000016.10:g.68823614C>G	TOPMed,gnomAD
COSM3511254	p.Ala719Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68823618C>T	NCI-TCGA Cosmic
rs764703133	p.Ala719Thr	missense variant	-	NC_000016.10:g.68823617G>A	ExAC,gnomAD
rs752041032	p.Ala719Asp	missense variant	-	NC_000016.10:g.68823618C>A	ExAC,gnomAD
rs1181973072	p.Leu720Val	missense variant	-	NC_000016.10:g.68823620T>G	gnomAD
RCV000736286	p.Leu721Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68823623C>G	ClinVar
rs878854682	p.Ile722Thr	missense variant	-	NC_000016.10:g.68828174T>C	-
RCV000232644	p.Ile722Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828174T>C	ClinVar
rs578069093	p.Leu727Phe	missense variant	-	NC_000016.10:g.68828188C>T	1000Genomes,ExAC,TOPMed,gnomAD
RCV000575210	p.Leu727Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828188C>T	ClinVar
RCV000544825	p.Leu727Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828188C>T	ClinVar
RCV000589724	p.Leu727Phe	missense variant	-	NC_000016.10:g.68828188C>T	ClinVar
RCV000699295	p.Leu729Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828195T>C	ClinVar
COSM5833154	p.Leu731PhePheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68828200C>-	NCI-TCGA Cosmic
COSM5833153	p.Leu731GlyPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68828197_68828200TTTC>-	NCI-TCGA Cosmic
rs1060501235	p.Leu731Phe	missense variant	-	NC_000016.10:g.68828200C>T	-
RCV000475537	p.Leu731Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828200C>T	ClinVar
RCV000569039	p.Arg732Trp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828203C>T	ClinVar
RCV000203693	p.Arg732Trp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828203C>T	ClinVar
rs864622198	p.Arg732Trp	missense variant	-	NC_000016.10:g.68828203C>T	TOPMed,gnomAD
rs1060501244	p.Arg732Gln	missense variant	-	NC_000016.10:g.68828204G>A	gnomAD
RCV000475163	p.Arg732Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828204G>A	ClinVar
rs1060501244	p.Arg732Leu	missense variant	-	NC_000016.10:g.68828204G>T	gnomAD
RCV000561514	p.Arg734Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828210G>C	ClinVar
RCV000480068	p.Arg734Thr	missense variant	-	NC_000016.10:g.68828210G>C	ClinVar
RCV000196295	p.Arg734Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828210G>C	ClinVar
RCV000130171	p.Arg734Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828210G>T	ClinVar
rs745717070	p.Arg734Ser	missense variant	-	NC_000016.10:g.68828211A>T	ExAC,gnomAD
rs587781859	p.Arg734Ile	missense variant	-	NC_000016.10:g.68828210G>T	TOPMed,gnomAD
RCV000538100	p.Arg734Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828211A>T	ClinVar
RCV000567522	p.Arg734Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828211A>T	ClinVar
rs587781859	p.Arg734Thr	missense variant	-	NC_000016.10:g.68828210G>C	TOPMed,gnomAD
RCV000206685	p.Ala735Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828213C>T	ClinVar
RCV000656824	p.Ala735Val	missense variant	-	NC_000016.10:g.68828213C>T	ClinVar
RCV000212382	p.Ala735Val	missense variant	-	NC_000016.10:g.68828213C>T	ClinVar
rs587782464	p.Ala735Val	missense variant	-	NC_000016.10:g.68828213C>T	ExAC,TOPMed,gnomAD
rs587782464	p.Ala735Gly	missense variant	-	NC_000016.10:g.68828213C>G	ExAC,TOPMed,gnomAD
RCV000775805	p.Ala735Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828213C>A	ClinVar
RCV000131554	p.Ala735Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828213C>T	ClinVar
RCV000460180	p.Ala735Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828213C>A	ClinVar
rs587782464	p.Ala735Glu	missense variant	-	NC_000016.10:g.68828213C>A	ExAC,TOPMed,gnomAD
RCV000582177	p.Val737Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828218G>A	ClinVar
rs1555517644	p.Val737Ile	missense variant	-	NC_000016.10:g.68828218G>A	-
rs768163102	p.Lys738Arg	missense variant	-	NC_000016.10:g.68828222A>G	ExAC,gnomAD
RCV000548418	p.Glu739Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828225A>G	ClinVar
rs1555517647	p.Glu739Gly	missense variant	-	NC_000016.10:g.68828225A>G	-
RCV000525737	p.Pro740Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828227C>T	ClinVar
RCV000335165	p.Pro740His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828228C>A	ClinVar
RCV000570624	p.Pro740Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828227C>G	ClinVar
RCV000567386	p.Pro740Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828227C>T	ClinVar
RCV000586796	p.Pro740Ser	missense variant	-	NC_000016.10:g.68828227C>T	ClinVar
rs773795943	p.Pro740Ala	missense variant	-	NC_000016.10:g.68828227C>G	ExAC,gnomAD
rs773795943	p.Pro740Ser	missense variant	-	NC_000016.10:g.68828227C>T	ExAC,gnomAD
RCV000160397	p.Pro740His	missense variant	-	NC_000016.10:g.68828228C>A	ClinVar
RCV000221772	p.Pro740His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828228C>A	ClinVar
rs730881669	p.Pro740His	missense variant	-	NC_000016.10:g.68828228C>A	ExAC,TOPMed,gnomAD
rs786203005	p.Pro743Thr	missense variant	-	NC_000016.10:g.68828236C>A	gnomAD
rs786203005	p.Pro743Ser	missense variant	-	NC_000016.10:g.68828236C>T	gnomAD
RCV000166116	p.Pro743Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828236C>T	ClinVar
rs786203005	p.Pro743Ala	missense variant	-	NC_000016.10:g.68828236C>G	gnomAD
RCV000639227	p.Pro743Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828236C>A	ClinVar
RCV000572929	p.Pro743Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828236C>A	ClinVar
RCV000222818	p.Pro743Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828236C>G	ClinVar
RCV000759014	p.Pro744Leu	missense variant	-	NC_000016.10:g.68828240C>T	ClinVar
rs1001200905	p.Pro744Leu	missense variant	-	NC_000016.10:g.68828240C>T	TOPMed
rs761146693	p.Pro744Ser	missense variant	-	NC_000016.10:g.68828239C>T	ExAC,gnomAD
RCV000462140	p.Pro744Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828240C>T	ClinVar
RCV000695844	p.Glu745Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828244G>T	ClinVar
rs1408841952	p.Asp746Gly	missense variant	-	NC_000016.10:g.68828246A>G	gnomAD
RCV000572586	p.Asp746Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828246A>G	ClinVar
rs766636655	p.Asp746Asn	missense variant	-	NC_000016.10:g.68828245G>A	ExAC,gnomAD
RCV000579596	p.Asp747Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828248G>A	ClinVar
rs769819324	p.Asp747Asn	missense variant	-	NC_000016.10:g.68828248G>A	-
RCV000461277	p.Asp747Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828249A>G	ClinVar
rs1060501222	p.Asp747Gly	missense variant	-	NC_000016.10:g.68828249A>G	-
RCV000568319	p.Thr748Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828252C>A	ClinVar
RCV000528425	p.Thr748Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828252C>A	ClinVar
RCV000781216	p.Thr748Ser	missense variant	-	NC_000016.10:g.68828252C>G	ClinVar
RCV000538680	p.Thr748Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828252C>G	ClinVar
rs1555517660	p.Thr748Ser	missense variant	-	NC_000016.10:g.68828252C>G	-
rs1555517660	p.Thr748Asn	missense variant	-	NC_000016.10:g.68828252C>A	-
RCV000479819	p.Arg749Trp	missense variant	-	NC_000016.10:g.68828254C>T	ClinVar
RCV000663000	p.Arg749Trp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828254C>T	ClinVar
RCV000774774	p.Arg749Trp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828254C>T	ClinVar
RCV000123244	p.Arg749Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828255G>A	ClinVar
RCV000164201	p.Arg749Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828255G>A	ClinVar
RCV000657030	p.Arg749Gln	missense variant	-	NC_000016.10:g.68828255G>A	ClinVar
rs530717933	p.Arg749Gln	missense variant	-	NC_000016.10:g.68828255G>A	TOPMed,gnomAD
rs776975632	p.Arg749Trp	missense variant	-	NC_000016.10:g.68828254C>T	ExAC,TOPMed
RCV000120503	p.Arg749Gln	missense variant	-	NC_000016.10:g.68828255G>A	ClinVar
RCV000690254	p.Asp750Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828257G>A	ClinVar
rs759608783	p.Asp750Gly	missense variant	-	NC_000016.10:g.68828258A>G	ExAC,gnomAD
RCV000554709	p.Asp750Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828258A>G	ClinVar
RCV000216187	p.Asp750Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828258A>G	ClinVar
rs33964119	p.Asn751Lys	missense variant	-	NC_000016.10:g.68828262C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs33964119	p.Asn751Lys	missense variant	-	NC_000016.10:g.68828262C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000229329	p.Val752Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828263G>A	ClinVar
RCV000129135	p.Val752Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828263G>A	ClinVar
RCV000479491	p.Val752Ile	missense variant	-	NC_000016.10:g.68828263G>A	ClinVar
rs587781351	p.Val752Ile	missense variant	-	NC_000016.10:g.68828263G>A	ExAC,TOPMed,gnomAD
rs587781351	p.Val752Leu	missense variant	-	NC_000016.10:g.68828263G>C	ExAC,TOPMed,gnomAD
RCV000411136	p.Tyr754Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828270A>G	ClinVar
RCV000165420	p.Tyr754Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828270A>G	ClinVar
RCV000485531	p.Tyr754Cys	missense variant	-	NC_000016.10:g.68828270A>G	ClinVar
rs767613429	p.Tyr754Cys	missense variant	-	NC_000016.10:g.68828270A>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Tyr754Ter	stop gained	-	NC_000016.10:g.68828271C>G	NCI-TCGA
NCI-TCGA novel	p.Tyr754AlaPheSerTerUnk	frameshift	-	NC_000016.10:g.68828233_68828234insTGCCCCCAGAGGATGACACCCGGGACAACGTTTA	NCI-TCGA
RCV000128868	p.Tyr755Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828273A>G	ClinVar
RCV000759727	p.Tyr755Cys	missense variant	-	NC_000016.10:g.68828273A>G	ClinVar
RCV000736287	p.Tyr755Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828274T>A	ClinVar
RCV000818773	p.Tyr755Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828273A>G	ClinVar
rs187289510	p.Tyr755Cys	missense variant	-	NC_000016.10:g.68828273A>G	1000Genomes,ExAC,gnomAD
RCV000639256	p.Asp756His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828275G>C	ClinVar
RCV000692039	p.Asp756Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828277T>G	ClinVar
rs1555517677	p.Asp756His	missense variant	-	NC_000016.10:g.68828275G>C	-
rs1064794232	p.Glu757Lys	missense variant	-	NC_000016.10:g.68828278G>A	-
RCV000478876	p.Glu757Lys	missense variant	-	NC_000016.10:g.68828278G>A	ClinVar
RCV000694526	p.Glu757Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828278G>A	ClinVar
NCI-TCGA novel	p.Glu757MetPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68828275_68828276insAT	NCI-TCGA
NCI-TCGA novel	p.Glu757Ter	frameshift	-	NC_000016.10:g.68828276_68828277insT	NCI-TCGA
RCV000639210	p.Glu758Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828281G>T	ClinVar
rs786202785	p.Glu758Lys	missense variant	-	NC_000016.10:g.68828281G>A	-
RCV000165772	p.Glu758Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828281G>A	ClinVar
RCV000568881	p.Gly759Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828285G>C	ClinVar
RCV000657197	p.Gly759Ter	frameshift	-	NC_000016.10:g.68828285del	ClinVar
rs945866627	p.Gly759Ala	missense variant	-	NC_000016.10:g.68828285G>C	TOPMed,gnomAD
RCV000639253	p.Gly759Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828285G>C	ClinVar
RCV000807990	p.Gly761Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828291G>C	ClinVar
RCV000492622	p.Gly761Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828290G>A	ClinVar
rs779648243	p.Gly761Arg	missense variant	-	NC_000016.10:g.68828290G>A	ExAC,gnomAD
RCV000571214	p.Gly761Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828291G>A	ClinVar
RCV000214313	p.Gly761Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828291G>C	ClinVar
RCV000462218	p.Gly761Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828290G>A	ClinVar
rs876659664	p.Gly761Ala	missense variant	-	NC_000016.10:g.68828291G>C	TOPMed
rs876659664	p.Gly761Glu	missense variant	-	NC_000016.10:g.68828291G>A	TOPMed
RCV000568475	p.Glu763Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828296G>T	ClinVar
RCV000223099	p.Glu763Ter	nonsense	-	NC_000016.10:g.68828296G>T	ClinVar
rs587780787	p.Glu763Ter	stop gained	-	NC_000016.10:g.68828296G>T	-
COSM5833156	p.Asp764GlyPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68828297_68828298insG	NCI-TCGA Cosmic
RCV000215264	p.Asp764Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828301C>A	ClinVar
RCV000553785	p.Asp764Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828300A>G	ClinVar
rs61747636	p.Asp764Glu	missense variant	-	NC_000016.10:g.68828301C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1555517687	p.Asp764Gly	missense variant	-	NC_000016.10:g.68828300A>G	-
rs876658575	p.Gln765Ter	stop gained	-	NC_000016.10:g.68828302C>T	-
RCV000709398	p.Gln765Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68828302C>T	ClinVar
RCV000222740	p.Gln765Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68828302C>T	ClinVar
NCI-TCGA novel	p.Gln765ProPheSerTerUnk	frameshift	-	NC_000016.10:g.68828300_68828301insC	NCI-TCGA
rs1471460728	p.Asp766His	missense variant	-	NC_000016.10:g.68829654G>C	TOPMed
RCV000473327	p.Asp768Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829660G>A	ClinVar
RCV000164575	p.Asp768Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829660G>A	ClinVar
rs786201999	p.Asp768Asn	missense variant	-	NC_000016.10:g.68829660G>A	TOPMed,gnomAD
rs1445658216	p.Asp768Glu	missense variant	-	NC_000016.10:g.68829662C>G	gnomAD
RCV000566098	p.Leu769Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829663T>G	ClinVar
rs766222121	p.Leu769Val	missense variant	-	NC_000016.10:g.68829663T>G	ExAC,gnomAD
RCV000492719	p.Gln771Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829669C>T	ClinVar
rs1182000968	p.Gln771Arg	missense variant	-	NC_000016.10:g.68829670A>G	TOPMed
rs1131690813	p.Gln771Ter	stop gained	-	NC_000016.10:g.68829669C>T	-
RCV000566685	p.His773Tyr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829675C>T	ClinVar
RCV000212384	p.His773Arg	missense variant	-	NC_000016.10:g.68829676A>G	ClinVar
rs587782823	p.His773Arg	missense variant	-	NC_000016.10:g.68829676A>G	TOPMed,gnomAD
RCV000132399	p.His773Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829676A>G	ClinVar
RCV000459654	p.His773Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829676A>G	ClinVar
rs1555517823	p.His773Tyr	missense variant	-	NC_000016.10:g.68829675C>T	-
RCV000483919	p.Arg774Gly	missense variant	-	NC_000016.10:g.68829678A>G	ClinVar
RCV000639284	p.Arg774Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829678A>G	ClinVar
RCV000570862	p.Arg774Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829678A>G	ClinVar
rs753540183	p.Arg774Gly	missense variant	-	NC_000016.10:g.68829678A>G	ExAC,TOPMed,gnomAD
RCV000773343	p.Gly775Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829682G>A	ClinVar
RCV000464624	p.Gly775Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829682del	ClinVar
COSM1180831	p.Gly775AlaPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68829679G>-	NCI-TCGA Cosmic
RCV000532237	p.Gly775Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829681G>A	ClinVar
rs778581202	p.Gly775Val	missense variant	-	NC_000016.10:g.68829682G>T	ExAC,TOPMed,gnomAD
rs1163417116	p.Gly775Ser	missense variant	-	NC_000016.10:g.68829681G>A	gnomAD
NCI-TCGA novel	p.Leu776Met	missense variant	-	NC_000016.10:g.68829684C>A	NCI-TCGA
RCV000561784	p.Asp777Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829689C>G	ClinVar
RCV000206674	p.Asp777Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829687G>A	ClinVar
RCV000463537	p.Asp777Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829689C>G	ClinVar
RCV000487740	p.Asp777Asn	missense variant	-	NC_000016.10:g.68829687G>A	ClinVar
rs114265540	p.Asp777Glu	missense variant	-	NC_000016.10:g.68829689C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs372989292	p.Asp777Asn	missense variant	-	NC_000016.10:g.68829687G>A	UniProt,dbSNP
VAR_033027	p.Asp777Asn	missense variant	-	NC_000016.10:g.68829687G>A	UniProt
rs372989292	p.Asp777Asn	missense variant	-	NC_000016.10:g.68829687G>A	ESP,ExAC,TOPMed,gnomAD
RCV000664263	p.Ala778Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829691C>G	ClinVar
RCV000233980	p.Ala778Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829690G>A	ClinVar
rs777078601	p.Ala778Thr	missense variant	-	NC_000016.10:g.68829690G>A	ExAC,TOPMed,gnomAD
rs876659951	p.Ala778Asp	missense variant	-	NC_000016.10:g.68829691C>A	TOPMed
RCV000573911	p.Ala778Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829691C>A	ClinVar
RCV000218359	p.Ala778Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829691C>T	ClinVar
RCV000562000	p.Ala778Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829690G>A	ClinVar
rs876659951	p.Ala778Gly	missense variant	-	NC_000016.10:g.68829691C>G	TOPMed
rs876659951	p.Ala778Val	missense variant	-	NC_000016.10:g.68829691C>T	TOPMed
RCV000780099	p.Arg779Trp	missense variant	-	NC_000016.10:g.68829693C>T	ClinVar
RCV000212385	p.Arg779Gln	missense variant	-	NC_000016.10:g.68829694G>A	ClinVar
RCV000218940	p.Arg779Trp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829693C>T	ClinVar
RCV000484296	p.Arg779Trp	missense variant	-	NC_000016.10:g.68829693C>T	ClinVar
RCV000227820	p.Arg779Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829694G>A	ClinVar
rs587781311	p.Arg779Gln	missense variant	-	NC_000016.10:g.68829694G>A	ExAC,TOPMed,gnomAD
rs876660183	p.Arg779Trp	missense variant	-	NC_000016.10:g.68829693C>T	-
RCV000457635	p.Arg779Trp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829693C>T	ClinVar
RCV000129040	p.Arg779Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829694G>A	ClinVar
RCV000557378	p.Pro780Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829697C>T	ClinVar
rs1555517841	p.Pro780Leu	missense variant	-	NC_000016.10:g.68829697C>T	-
RCV000225693	p.Glu781Asp	missense variant	-	NC_000016.10:g.68829701A>T	ClinVar
RCV000761048	p.Glu781Asp	missense variant	Mixed Phenotype Acute Leukemia with t(v;11q23.3); KMT2A Rearranged	NC_000016.10:g.68829701A>T	ClinVar
rs587780119	p.Glu781Asp	missense variant	-	NC_000016.10:g.68829701A>T	ExAC,TOPMed,gnomAD
RCV000780095	p.Glu781Asp	missense variant	-	NC_000016.10:g.68829701A>T	ClinVar
RCV000234640	p.Glu781Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829701A>T	ClinVar
rs746274636	p.Val782Ala	missense variant	-	NC_000016.10:g.68829703T>C	ExAC,gnomAD
RCV000217807	p.Thr783Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829706C>T	ClinVar
RCV000699151	p.Thr783Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829706C>T	ClinVar
rs876658467	p.Thr783Ile	missense variant	-	NC_000016.10:g.68829706C>T	TOPMed,gnomAD
RCV000481744	p.Arg784His	missense variant	-	NC_000016.10:g.68829709G>A	ClinVar
RCV000219916	p.Arg784Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829708C>T	ClinVar
RCV000563859	p.Arg784His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829709G>A	ClinVar
RCV000761165	p.Arg784Pro	missense variant	Papillary thyroid carcinoma	NC_000016.10:g.68829709G>C	ClinVar
rs763203357	p.Arg784His	missense variant	-	NC_000016.10:g.68829709G>A	ExAC,gnomAD
RCV000531308	p.Arg784Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829708C>T	ClinVar
RCV000204130	p.Arg784His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829709G>A	ClinVar
rs775922721	p.Arg784Cys	missense variant	-	NC_000016.10:g.68829708C>T	ExAC,gnomAD
NCI-TCGA novel	p.Asn785Ser	missense variant	-	NC_000016.10:g.68829712A>G	NCI-TCGA
RCV000471268	p.Asp786Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829714G>A	ClinVar
rs876659218	p.Asp786Asn	missense variant	-	NC_000016.10:g.68829714G>A	-
RCV000214749	p.Asp786Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829714G>A	ClinVar
RCV000168317	p.Val787Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829717G>A	ClinVar
RCV000165982	p.Val787Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829717G>A	ClinVar
rs766270336	p.Val787Ile	missense variant	-	NC_000016.10:g.68829717G>A	ExAC,TOPMed,gnomAD
RCV000545072	p.Ala788Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829721C>T	ClinVar
RCV000506194	p.Ala788Val	missense variant	-	NC_000016.10:g.68829721C>T	ClinVar
RCV000129335	p.Ala788Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829721C>T	ClinVar
rs139096339	p.Ala788Val	missense variant	-	NC_000016.10:g.68829721C>T	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala788GluPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68829719_68829732TGCACCAACCCTCA>-	NCI-TCGA
RCV000693109	p.Pro789Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829724C>T	ClinVar
RCV000212386	p.Thr790Ile	missense variant	-	NC_000016.10:g.68829727C>T	ClinVar
RCV000115853	p.Thr790Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829727C>T	ClinVar
RCV000123246	p.Thr790Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829727C>T	ClinVar
rs587780120	p.Thr790Ile	missense variant	-	NC_000016.10:g.68829727C>T	TOPMed,gnomAD
RCV000205557	p.Leu791Phe	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829729C>T	ClinVar
RCV000165485	p.Leu791Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829729C>T	ClinVar
rs786202598	p.Leu791Phe	missense variant	-	NC_000016.10:g.68829729C>T	TOPMed,gnomAD
RCV000693192	p.Met792Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829732A>G	ClinVar
RCV000566576	p.Met792Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829733T>C	ClinVar
RCV000706062	p.Met792Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829733T>C	ClinVar
RCV000482374	p.Met792Thr	missense variant	-	NC_000016.10:g.68829733T>C	ClinVar
RCV000696925	p.Met792Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829732A>C	ClinVar
RCV000222815	p.Met792Val	missense variant	-	NC_000016.10:g.68829732A>G	ClinVar
rs752349229	p.Met792Thr	missense variant	-	NC_000016.10:g.68829733T>C	ExAC,gnomAD
rs759380419	p.Met792Leu	missense variant	-	NC_000016.10:g.68829732A>C	ExAC,gnomAD
rs759380419	p.Met792Val	missense variant	-	NC_000016.10:g.68829732A>G	ExAC,gnomAD
RCV000166300	p.Ser793Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829737T>G	ClinVar
rs786203128	p.Ser793Arg	missense variant	-	NC_000016.10:g.68829737T>G	-
rs1357766058	p.Ser793Asn	missense variant	-	NC_000016.10:g.68829736G>A	gnomAD
RCV000484196	p.Val794Ile	missense variant	-	NC_000016.10:g.68829738G>A	ClinVar
RCV000131558	p.Val794Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829738G>A	ClinVar
RCV000559870	p.Val794Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829739T>C	ClinVar
rs1447544874	p.Val794Ala	missense variant	-	NC_000016.10:g.68829739T>C	gnomAD
rs587782466	p.Val794Ile	missense variant	-	NC_000016.10:g.68829738G>A	ExAC,TOPMed,gnomAD
RCV000205207	p.Val794Ile	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829738G>A	ClinVar
NCI-TCGA novel	p.Val794ProPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68829727_68829728insCCTCATGAGT	NCI-TCGA
RCV000639242	p.Pro795Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829742C>G	ClinVar
rs1298997936	p.Pro795Ser	missense variant	-	NC_000016.10:g.68829741C>T	gnomAD
rs1555517888	p.Pro795Arg	missense variant	-	NC_000016.10:g.68829742C>G	-
RCV000582952	p.Arg796Trp	missense variant	-	NC_000016.10:g.68829744C>T	ClinVar
RCV000792585	p.Arg796Trp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829744C>T	ClinVar
RCV000639217	p.Arg796Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829745_68829764del	ClinVar
RCV000228473	p.Arg796Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829745G>A	ClinVar
rs587782549	p.Arg796Gln	missense variant	-	NC_000016.10:g.68829745G>A	ExAC,TOPMed,gnomAD
RCV000587217	p.Arg796Gln	missense variant	-	NC_000016.10:g.68829745G>A	ClinVar
RCV000013023	p.Arg796Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829744dup	ClinVar
rs777363517	p.Arg796Trp	missense variant	-	NC_000016.10:g.68829744C>T	ExAC,TOPMed,gnomAD
RCV000131408	p.Tyr797Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829748A>G	ClinVar
rs587782394	p.Tyr797Cys	missense variant	-	NC_000016.10:g.68829748A>G	-
COSM1302179	p.Leu798Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68829750C>G	NCI-TCGA Cosmic
RCV000167901	p.Pro799Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829754C>G	ClinVar
rs587781335	p.Pro799Arg	missense variant	-	NC_000016.10:g.68829754C>G	-
RCV000129091	p.Pro799Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829754C>G	ClinVar
NCI-TCGA novel	p.Pro799Leu	missense variant	-	NC_000016.10:g.68829754C>T	NCI-TCGA
RCV000212387	p.Arg800His	missense variant	-	NC_000016.10:g.68829757G>A	ClinVar
RCV000592579	p.Arg800Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829756del	ClinVar
RCV000204619	p.Arg800Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829756C>T	ClinVar
RCV000130753	p.Arg800Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829756C>T	ClinVar
rs370345996	p.Arg800Pro	missense variant	-	NC_000016.10:g.68829757G>C	ESP,ExAC,TOPMed,gnomAD
RCV000639262	p.Arg800Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829757G>T	ClinVar
RCV000198268	p.Arg800His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829757G>A	ClinVar
RCV000765308	p.Arg800Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829756C>T	ClinVar
RCV000131445	p.Arg800His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829757G>A	ClinVar
rs370345996	p.Arg800Leu	missense variant	-	NC_000016.10:g.68829757G>T	ESP,ExAC,TOPMed,gnomAD
rs587782162	p.Arg800Cys	missense variant	-	NC_000016.10:g.68829756C>T	ExAC,TOPMed,gnomAD
rs370345996	p.Arg800His	missense variant	-	NC_000016.10:g.68829757G>A	ESP,ExAC,TOPMed,gnomAD
RCV000144591	p.Arg800Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829756del	ClinVar
RCV000657198	p.Arg800Ter	frameshift	-	NC_000016.10:g.68829756del	ClinVar
RCV000796116	p.Pro801Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829759C>G	ClinVar
COSM5833158	p.Pro801LeuPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68829758C>-	NCI-TCGA Cosmic
rs876660704	p.Pro801Ala	missense variant	-	NC_000016.10:g.68829759C>G	gnomAD
RCV000217230	p.Pro801Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829759C>G	ClinVar
RCV000562840	p.Asn803Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829765A>G	ClinVar
rs780510260	p.Asn803Asp	missense variant	-	NC_000016.10:g.68829765A>G	ExAC,gnomAD
RCV000564560	p.Asp805Gly	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829772A>G	ClinVar
RCV000115854	p.Asp805Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829771G>A	ClinVar
RCV000120505	p.Asp805Asn	missense variant	-	NC_000016.10:g.68829771G>A	ClinVar
RCV000705266	p.Asp805Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829772A>G	ClinVar
rs200894246	p.Asp805Asn	missense variant	-	NC_000016.10:g.68829771G>A	ESP,ExAC,TOPMed,gnomAD
rs1481419710	p.Asp805Gly	missense variant	-	NC_000016.10:g.68829772A>G	gnomAD
rs376922615	p.Glu806Lys	missense variant	-	NC_000016.10:g.68829774G>A	ESP,ExAC,TOPMed,gnomAD
RCV000533790	p.Glu806Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829774G>A	ClinVar
RCV000217698	p.Glu806Lys	missense variant	-	NC_000016.10:g.68829774G>A	ClinVar
rs761852331	p.Ile807Met	missense variant	-	NC_000016.10:g.68829779T>G	ExAC,gnomAD
RCV000701265	p.Asn809Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829784A>G	ClinVar
rs772173832	p.Asn809Lys	missense variant	-	NC_000016.10:g.68829785T>A	ExAC,gnomAD
rs1427872591	p.Asn809Ser	missense variant	-	NC_000016.10:g.68829784A>G	TOPMed,gnomAD
RCV000204049	p.Phe810Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829788del	ClinVar
rs1178559383	p.Phe810Leu	missense variant	-	NC_000016.10:g.68829786T>C	gnomAD
RCV000167195	p.Phe810Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68829788del	ClinVar
RCV000689679	p.Phe810Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829786T>C	ClinVar
rs1236811420	p.Phe810Cys	missense variant	-	NC_000016.10:g.68829787T>G	TOPMed
RCV000484305	p.Phe810Ter	frameshift	-	NC_000016.10:g.68829788del	ClinVar
RCV000558957	p.Ile811Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829790T>C	ClinVar
RCV000548706	p.Ile811Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829789A>G	ClinVar
rs1555517918	p.Ile811Thr	missense variant	-	NC_000016.10:g.68829790T>C	-
rs1555517917	p.Ile811Val	missense variant	-	NC_000016.10:g.68829789A>G	-
RCV000232461	p.Asp812Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68829793A>G	ClinVar
rs878854684	p.Asp812Gly	missense variant	-	NC_000016.10:g.68829793A>G	-
rs1413760846	p.Glu813Asp	missense variant	-	NC_000016.10:g.68829797A>T	gnomAD
RCV000547768	p.Lys816Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833298A>C	ClinVar
RCV000562032	p.Lys816Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833296A>G	ClinVar
RCV000593954	p.Lys816Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833296A>T	ClinVar
RCV000639208	p.Lys816Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833296A>T	ClinVar
rs762704513	p.Lys816Asn	missense variant	-	NC_000016.10:g.68833298A>C	ExAC,gnomAD
rs1555518211	p.Lys816Ter	stop gained	-	NC_000016.10:g.68833296A>T	-
RCV000471390	p.Ala817Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833300C>T	ClinVar
RCV000383518	p.Ala817Val	missense variant	-	NC_000016.10:g.68833300C>T	ClinVar
RCV000656825	p.Ala817Val	missense variant	-	NC_000016.10:g.68833300C>T	ClinVar
rs587782024	p.Ala817Val	missense variant	-	NC_000016.10:g.68833300C>T	ExAC,TOPMed,gnomAD
RCV000130457	p.Ala817Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833300C>T	ClinVar
rs1223994260	p.Ala818Thr	missense variant	-	NC_000016.10:g.68833302G>A	gnomAD
COSM4833222	p.Asp819Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68833305G>A	NCI-TCGA Cosmic
rs767159815	p.Thr820Ile	missense variant	-	NC_000016.10:g.68833309C>T	ExAC,gnomAD
RCV000228053	p.Thr820Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833308A>G	ClinVar
RCV000485072	p.Thr820Ile	missense variant	-	NC_000016.10:g.68833309C>T	ClinVar
RCV000569945	p.Thr820Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833309C>T	ClinVar
rs878854685	p.Thr820Ala	missense variant	-	NC_000016.10:g.68833308A>G	TOPMed
RCV000472121	p.Pro822Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833314C>G	ClinVar
RCV000467419	p.Pro822Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833314C>T	ClinVar
RCV000639250	p.Pro822Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833315C>T	ClinVar
rs876660086	p.Pro822Ala	missense variant	-	NC_000016.10:g.68833314C>G	-
rs876660086	p.Pro822Ser	missense variant	-	NC_000016.10:g.68833314C>T	-
rs1555518215	p.Pro822Leu	missense variant	-	NC_000016.10:g.68833315C>T	-
RCV000213124	p.Pro822Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833314C>T	ClinVar
RCV000574257	p.Thr823Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833317A>G	ClinVar
RCV000232027	p.Thr823Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833317A>G	ClinVar
rs878854686	p.Thr823Ala	missense variant	-	NC_000016.10:g.68833317A>G	-
rs1450920019	p.Ala824Val	missense variant	-	NC_000016.10:g.68833321C>T	gnomAD
COSM5833159	p.Ala824GlyPheSerTerUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68833319_68833320insG	NCI-TCGA Cosmic
RCV000639238	p.Ala824Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833321C>T	ClinVar
RCV000527398	p.Ala824Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833321C>A	ClinVar
rs1450920019	p.Ala824Asp	missense variant	-	NC_000016.10:g.68833321C>A	gnomAD
RCV000765309	p.Pro825Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833324C>T	ClinVar
RCV000129041	p.Pro825Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833324C>T	ClinVar
rs587781312	p.Pro825Leu	missense variant	-	NC_000016.10:g.68833324C>T	ExAC,TOPMed,gnomAD
RCV000200831	p.Pro825Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833324C>T	ClinVar
RCV000478861	p.Pro825Leu	missense variant	-	NC_000016.10:g.68833324C>T	ClinVar
RCV000574087	p.Pro826Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833324dup	ClinVar
RCV000792226	p.Pro826Ter	frameshift	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833324dup	ClinVar
NCI-TCGA novel	p.Pro826LeuPheSerTerUnkUnk	frameshift	-	NC_000016.10:g.68833326C>-	NCI-TCGA
RCV000548051	p.Tyr827Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833330A>G	ClinVar
rs1555518224	p.Tyr827Cys	missense variant	-	NC_000016.10:g.68833330A>G	-
rs767045364	p.Tyr827Ter	stop gained	-	NC_000016.10:g.68833331T>G	ExAC,gnomAD
RCV000526467	p.Ser829Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833335T>G	ClinVar
RCV000205814	p.Ser829Tyr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833336C>A	ClinVar
rs864622310	p.Ser829Tyr	missense variant	-	NC_000016.10:g.68833336C>A	-
rs1265463733	p.Ser829Ala	missense variant	-	NC_000016.10:g.68833335T>G	TOPMed
NCI-TCGA novel	p.Ser829Ter	frameshift	-	NC_000016.10:g.68833330_68833331insTGAT	NCI-TCGA
RCV000492088	p.Leu831Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833340dup	ClinVar
rs35572355	p.Val832Met	missense variant	-	NC_000016.10:g.68833344G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs35572355	p.Val832Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833344G>A	UniProt,dbSNP
VAR_023358	p.Val832Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833344G>A	UniProt
rs35572355	p.Val832Leu	missense variant	-	NC_000016.10:g.68833344G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000587650	p.Val832Met	missense variant	-	NC_000016.10:g.68833344G>A	ClinVar
RCV000196588	p.Phe833Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833347T>C	ClinVar
rs863224728	p.Phe833Leu	missense variant	-	NC_000016.10:g.68833347T>C	-
RCV000686764	p.Asp834Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833350G>A	ClinVar
NCI-TCGA novel	p.Asp834Ter	frameshift	-	NC_000016.10:g.68833346_68833347insT	NCI-TCGA
COSM3818356	p.Tyr835Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000016.10:g.68833355T>A	NCI-TCGA Cosmic
RCV000565359	p.Glu836Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833355_68833356dup	ClinVar
RCV000736285	p.Glu836Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833356G>T	ClinVar
RCV000013020	p.Ser838Gly	missense variant	Neoplasm of ovary	NC_000016.10:g.68833362A>G	ClinVar
rs121964872	p.Ser838Gly	missense variant	-	NC_000016.10:g.68833362A>G	ESP,ExAC,TOPMed,gnomAD
rs121964872	p.Ser838Gly	missense variant	-	NC_000016.10:g.68833362A>G	UniProt,dbSNP
VAR_001322	p.Ser838Gly	missense variant	-	NC_000016.10:g.68833362A>G	UniProt
RCV000115858	p.Gly839Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833365G>A	ClinVar
RCV000231558	p.Gly839Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833365G>A	ClinVar
RCV000212391	p.Gly839Ser	missense variant	-	NC_000016.10:g.68833365G>A	ClinVar
rs587780121	p.Gly839Ser	missense variant	-	NC_000016.10:g.68833365G>A	ExAC,TOPMed,gnomAD
RCV000541339	p.Ser840Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833368T>C	ClinVar
rs1555518243	p.Ser840Pro	missense variant	-	NC_000016.10:g.68833368T>C	-
RCV000129009	p.Ser840Phe	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833369C>T	ClinVar
RCV000580210	p.Ser840Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833368T>C	ClinVar
rs587781300	p.Ser840Phe	missense variant	-	NC_000016.10:g.68833369C>T	-
RCV000467375	p.Glu841Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833371G>A	ClinVar
RCV000217393	p.Glu841Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833371G>A	ClinVar
RCV000481767	p.Glu841Lys	missense variant	-	NC_000016.10:g.68833371G>A	ClinVar
rs377489352	p.Glu841Lys	missense variant	-	NC_000016.10:g.68833371G>A	gnomAD
RCV000167225	p.Ala842Pro	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833374G>C	ClinVar
rs786203774	p.Ala842Pro	missense variant	-	NC_000016.10:g.68833374G>C	-
RCV000572215	p.Ala843Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833377G>A	ClinVar
RCV000701451	p.Ala843Thr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833377G>A	ClinVar
rs774148258	p.Ala843Gly	missense variant	-	NC_000016.10:g.68833378C>G	ExAC,gnomAD
rs768350776	p.Ala843Thr	missense variant	-	NC_000016.10:g.68833377G>A	ExAC,gnomAD
RCV000568605	p.Ser844Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833381G>T	ClinVar
rs1247754103	p.Ser844Ile	missense variant	-	NC_000016.10:g.68833381G>T	gnomAD
RCV000774780	p.Ser844Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833380A>T	ClinVar
RCV000773015	p.Ser844Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833381G>C	ClinVar
RCV000781208	p.Ser844Ile	missense variant	-	NC_000016.10:g.68833381G>T	ClinVar
rs761400928	p.Ser844Cys	missense variant	-	NC_000016.10:g.68833380A>T	ExAC,gnomAD
RCV000556174	p.Ser847Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833389T>G	ClinVar
RCV000563237	p.Ser847Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833389T>G	ClinVar
RCV000639221	p.Ser847Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833390C>G	ClinVar
rs1555518248	p.Ser847Ala	missense variant	-	NC_000016.10:g.68833389T>G	-
rs1555518249	p.Ser847Cys	missense variant	-	NC_000016.10:g.68833390C>G	-
rs767315263	p.Leu848Pro	missense variant	-	NC_000016.10:g.68833393T>C	ExAC,gnomAD
RCV000222119	p.Asn849Asp	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833395A>G	ClinVar
RCV000685079	p.Asn849Asp	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833395A>G	ClinVar
rs876660881	p.Asn849Asp	missense variant	-	NC_000016.10:g.68833395A>G	-
RCV000214510	p.Ser850Ter	frameshift	-	NC_000016.10:g.68833397_68833398insA	ClinVar
RCV000530113	p.Ser850Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833399C>G	ClinVar
RCV000130681	p.Ser850Ter	frameshift	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833399_68833400del	ClinVar
rs1337211551	p.Ser850Cys	missense variant	-	NC_000016.10:g.68833399C>G	TOPMed
RCV000564119	p.Ser850Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833399C>G	ClinVar
NCI-TCGA novel	p.Ser850Phe	missense variant	-	NC_000016.10:g.68833399C>T	NCI-TCGA
RCV000563765	p.Glu852Ala	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833405A>C	ClinVar
rs760315494	p.Glu852Asp	missense variant	-	NC_000016.10:g.68833406G>T	ExAC,gnomAD
rs1485384861	p.Glu852Ala	missense variant	-	NC_000016.10:g.68833405A>C	TOPMed,gnomAD
RCV000466545	p.Ser853Leu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833408C>T	ClinVar
RCV000165032	p.Ser853Leu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833408C>T	ClinVar
RCV000639259	p.Ser853Pro	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833407T>C	ClinVar
rs765978401	p.Ser853Pro	missense variant	-	NC_000016.10:g.68833407T>C	ExAC,gnomAD
rs569928380	p.Ser853Leu	missense variant	-	NC_000016.10:g.68833408C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs765978401	p.Ser853Thr	missense variant	-	NC_000016.10:g.68833407T>A	ExAC,gnomAD
RCV000759731	p.Ser853Leu	missense variant	-	NC_000016.10:g.68833408C>T	ClinVar
RCV000580229	p.Asp854Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833410G>A	ClinVar
rs1172127740	p.Asp854Glu	missense variant	-	NC_000016.10:g.68833412C>A	TOPMed
rs1555518257	p.Asp854Asn	missense variant	-	NC_000016.10:g.68833410G>A	-
NCI-TCGA novel	p.Asp854LysPheSerTerUnk	frameshift	-	NC_000016.10:g.68833408_68833411CAGA>-	NCI-TCGA
RCV000704078	p.Asp856Ala	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833417A>C	ClinVar
RCV000130458	p.Asp858His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833422G>C	ClinVar
RCV000200282	p.Asp858His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833422G>C	ClinVar
RCV000483138	p.Asp858His	missense variant	-	NC_000016.10:g.68833422G>C	ClinVar
RCV000561082	p.Asp858Glu	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833424C>A	ClinVar
RCV000462875	p.Asp858Glu	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833424C>A	ClinVar
rs1060501245	p.Asp858Glu	missense variant	-	NC_000016.10:g.68833424C>A	-
rs587782025	p.Asp858His	missense variant	-	NC_000016.10:g.68833422G>C	ExAC,gnomAD
RCV000567113	p.Asp860Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833428G>A	ClinVar
RCV000700036	p.Asp860Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833428G>A	ClinVar
RCV000700425	p.Asp860His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833428G>C	ClinVar
RCV000554143	p.Asp860Tyr	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833428G>T	ClinVar
rs1412506259	p.Asp860Tyr	missense variant	-	NC_000016.10:g.68833428G>T	TOPMed
rs1412506259	p.Asp860Asn	missense variant	-	NC_000016.10:g.68833428G>A	TOPMed
rs1185746867	p.Tyr861His	missense variant	-	NC_000016.10:g.68833431T>C	gnomAD
RCV000639267	p.Asn863Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833439C>A	ClinVar
RCV000215906	p.Asn863Lys	missense variant	-	NC_000016.10:g.68833439C>A	ClinVar
rs115817750	p.Asn863Lys	missense variant	-	NC_000016.10:g.68833439C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000575500	p.Glu864Gln	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833440G>C	ClinVar
RCV000205018	p.Glu864Gln	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833440G>C	ClinVar
RCV000216670	p.Glu864Lys	missense variant	-	NC_000016.10:g.68833440G>A	ClinVar
RCV000563816	p.Glu864Lys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833440G>A	ClinVar
RCV000471203	p.Glu864Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833440G>A	ClinVar
rs142927667	p.Glu864Gln	missense variant	-	NC_000016.10:g.68833440G>C	ESP,ExAC,TOPMed,gnomAD
rs142927667	p.Glu864Lys	missense variant	-	NC_000016.10:g.68833440G>A	ESP,ExAC,TOPMed,gnomAD
RCV000597446	p.Trp865Ter	nonsense	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833444G>A	ClinVar
rs1555518270	p.Trp865Ter	stop gained	-	NC_000016.10:g.68833444G>A	-
rs778019174	p.Trp865Cys	missense variant	-	NC_000016.10:g.68833445G>C	ExAC,gnomAD
RCV000197400	p.Trp865Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833445G>C	ClinVar
RCV000765310	p.Trp865Cys	missense variant	Familial cancer of breast	NC_000016.10:g.68833445G>C	ClinVar
RCV000572174	p.Trp865Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833445G>C	ClinVar
rs1555518267	p.Trp865Gly	missense variant	-	NC_000016.10:g.68833443T>G	-
RCV000662745	p.Trp865Ter	nonsense	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833444G>A	ClinVar
RCV000639215	p.Trp865Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833443T>G	ClinVar
RCV000472243	p.Gly866Ser	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833446G>A	ClinVar
rs1410318220	p.Gly866Asp	missense variant	-	NC_000016.10:g.68833447G>A	gnomAD
rs1060501230	p.Gly866Ser	missense variant	-	NC_000016.10:g.68833446G>A	-
RCV000132006	p.Asn867Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833450A>G	ClinVar
RCV000482832	p.Asn867Ser	missense variant	-	NC_000016.10:g.68833450A>G	ClinVar
RCV000766437	p.Asn867Ser	missense variant	-	NC_000016.10:g.68833450A>G	ClinVar
rs587782623	p.Asn867Ser	missense variant	-	NC_000016.10:g.68833450A>G	ExAC,gnomAD
RCV000217355	p.Arg868Cys	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833452C>T	ClinVar
RCV000478079	p.Arg868Cys	missense variant	-	NC_000016.10:g.68833452C>T	ClinVar
RCV000485189	p.Arg868His	missense variant	-	NC_000016.10:g.68833453G>A	ClinVar
RCV000572005	p.Arg868Ser	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833452C>A	ClinVar
RCV000233357	p.Arg868His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833453G>A	ClinVar
RCV000218816	p.Arg868His	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833453G>A	ClinVar
rs369126891	p.Arg868His	missense variant	-	NC_000016.10:g.68833453G>A	ESP,ExAC,TOPMed,gnomAD
rs864622630	p.Arg868Ser	missense variant	-	NC_000016.10:g.68833452C>A	TOPMed,gnomAD
rs864622630	p.Arg868Cys	missense variant	-	NC_000016.10:g.68833452C>T	TOPMed,gnomAD
RCV000205707	p.Arg868Cys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833452C>T	ClinVar
rs781274240	p.Lys870Thr	missense variant	-	NC_000016.10:g.68833459A>C	ExAC,gnomAD
rs781274240	p.Lys870Arg	missense variant	-	NC_000016.10:g.68833459A>G	ExAC,gnomAD
RCV000570434	p.Lys870Thr	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833459A>C	ClinVar
RCV000816835	p.Leu872Met	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833464C>A	ClinVar
RCV000562588	p.Leu872Met	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833464C>A	ClinVar
rs749203461	p.Leu872Met	missense variant	-	NC_000016.10:g.68833464C>A	ExAC,gnomAD
COSM4644008	p.Ala873Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000016.10:g.68833467G>A	NCI-TCGA Cosmic
rs1457628508	p.Ala873Gly	missense variant	-	NC_000016.10:g.68833468C>G	TOPMed
RCV000542909	p.Asp874His	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833470G>C	ClinVar
rs1555518283	p.Asp874His	missense variant	-	NC_000016.10:g.68833470G>C	-
RCV000572512	p.Met875Ile	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833475G>A	ClinVar
RCV000581138	p.Met875Val	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833473A>G	ClinVar
rs1555518287	p.Met875Val	missense variant	-	NC_000016.10:g.68833473A>G	-
rs1555518291	p.Met875Ile	missense variant	-	NC_000016.10:g.68833475G>A	-
rs900118000	p.Met875Arg	missense variant	-	NC_000016.10:g.68833474T>G	gnomAD
RCV000480709	p.Gly877Arg	missense variant	-	NC_000016.10:g.68833479G>A	ClinVar
RCV000567842	p.Gly877Arg	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833479G>A	ClinVar
RCV000639205	p.Gly877Arg	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833479G>A	ClinVar
rs555842031	p.Gly877Arg	missense variant	-	NC_000016.10:g.68833479G>A	1000Genomes,ExAC,gnomAD
RCV000706626	p.Gly879Val	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833486G>T	ClinVar
rs200911775	p.Gly879Ser	missense variant	-	NC_000016.10:g.68833485G>A	ESP,ExAC,TOPMed,gnomAD
RCV000212393	p.Gly879Ser	missense variant	-	NC_000016.10:g.68833485G>A	ClinVar
rs200911775	p.Gly879Arg	missense variant	-	NC_000016.10:g.68833485G>C	ESP,ExAC,TOPMed,gnomAD
RCV000639280	p.Glu880Gly	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833489A>G	ClinVar
rs34507583	p.Glu880Lys	missense variant	-	NC_000016.10:g.68833488G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs34507583	p.Glu880Lys	missense variant	-	NC_000016.10:g.68833488G>A	UniProt,dbSNP
VAR_023359	p.Glu880Lys	missense variant	-	NC_000016.10:g.68833488G>A	UniProt
RCV000230051	p.Glu880Lys	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833488G>A	ClinVar
RCV000484409	p.Glu880Gln	missense variant	-	NC_000016.10:g.68833488G>C	ClinVar
rs34507583	p.Glu880Gln	missense variant	-	NC_000016.10:g.68833488G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs1555518306	p.Glu880Gly	missense variant	-	NC_000016.10:g.68833489A>G	-
RCV000796701	p.Asp881Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833491G>A	ClinVar
RCV000572516	p.Asp881Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833491G>A	ClinVar
rs1198941336	p.Asp881Asn	missense variant	-	NC_000016.10:g.68833491G>A	gnomAD
RCV000115860	p.Asp882Asn	missense variant	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833494G>A	ClinVar
RCV000232913	p.Asp882Asn	missense variant	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833494G>A	ClinVar
RCV000212394	p.Asp882Asn	missense variant	-	NC_000016.10:g.68833494G>A	ClinVar
rs200104963	p.Asp882Asn	missense variant	-	NC_000016.10:g.68833494G>A	ExAC,TOPMed,gnomAD
RCV000475260	p.Ter883Gln	stop lost	Hereditary diffuse gastric cancer (HDGC)	NC_000016.10:g.68833497T>C	ClinVar
RCV000563805	p.Ter883Gln	stop lost	Hereditary cancer-predisposing syndrome	NC_000016.10:g.68833497T>C	ClinVar
rs932491569	p.Ter883Gln	stop lost	-	NC_000016.10:g.68833497T>C	TOPMed
rs1057523505	p.Ter883Leu	stop lost	-	NC_000016.10:g.68833498A>T	gnomAD
rs1057523505	p.Ter883Trp	stop lost	-	NC_000016.10:g.68833498A>G	gnomAD
RCV000425377	p.Ter883Leu	stop lost	-	NC_000016.10:g.68833498A>T	ClinVar

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0001418	Adenocarcinoma	group	BEFREE;LHGDN
C0001430	Adenoma	group	BEFREE
C0002395	Alzheimer's Disease	disease	BEFREE
C0002793	Anaplasia	disease	BEFREE
C0004096	Asthma	disease	BEFREE;LHGDN
C0004114	Astrocytoma	disease	BEFREE
C0004153	Atherosclerosis	disease	LHGDN
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE;CTD_human;RGD
C0005695	Bladder Neoplasm	group	BEFREE;CTD_human;LHGDN;RGD
C0005699	Blast Phase	disease	BEFREE
C0006118	Brain Neoplasms	group	LHGDN
C0006142	Malignant neoplasm of breast	disease	BEFREE;CTD_human;UNIPROT
C0006826	Malignant Neoplasms	group	BEFREE;CGI
C0007097	Carcinoma	group	CTD_human
C0007102	Malignant tumor of colon	disease	BEFREE
C0007103	Malignant neoplasm of endometrium	disease	BEFREE
C0007124	Noninfiltrating Intraductal Carcinoma	disease	BEFREE
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE
C0007133	Carcinoma, Papillary	disease	BEFREE
C0007134	Renal Cell Carcinoma	disease	BEFREE
C0007137	Squamous cell carcinoma	disease	BEFREE;CTD_human;LHGDN
C0007138	Carcinoma, Transitional Cell	disease	BEFREE;LHGDN
C0007621	Neoplastic Cell Transformation	phenotype	CTD_human
C0007847	Malignant tumor of cervix	disease	BEFREE
C0007873	Uterine Cervical Neoplasm	disease	LHGDN
C0008626	Congenital chromosomal disease	group	BEFREE
C0008924	Cleft upper lip	disease	HPO
C0009324	Ulcerative Colitis	disease	BEFREE;CTD_human
C0009375	Colonic Neoplasms	group	LHGDN
C0009402	Colorectal Carcinoma	disease	BEFREE;CTD_human
C0009404	Colorectal Neoplasms	group	BEFREE;CTD_human;LHGDN
C0009405	Hereditary Nonpolyposis Colorectal Neoplasms	group	CLINGEN
C0010346	Crohn Disease	disease	BEFREE
C0010606	Adenoid Cystic Carcinoma	disease	BEFREE;CTD_human;LHGDN
C0010709	Cyst	phenotype	BEFREE
C0010823	Cytomegalovirus Infections	group	BEFREE
C0011334	Dental caries	disease	HPO
C0013377	Dysgerminoma	disease	HPO
C0013595	Eczema	disease	LHGDN
C0014170	Endometrial Neoplasms	group	BEFREE;CTD_human;LHGDN
C0014175	Endometriosis	disease	BEFREE;LHGDN
C0014476	Eperythrozoonosis	disease	CTD_human
C0014859	Esophageal Neoplasms	group	BEFREE;LHGDN
C0015625	Fanconi Anemia	disease	BEFREE
C0016978	gallbladder neoplasm	disease	LHGDN
C0017150	Gastrinoma	disease	BEFREE
C0017152	Gastritis	disease	BEFREE;LHGDN
C0017154	Gastritis, Atrophic	disease	HPO
C0017185	Gastrointestinal Neoplasms	group	GENOMICS_ENGLAND
C0017612	Glaucoma, Open-Angle	disease	LHGDN
C0017638	Glioma	disease	BEFREE
C0018777	Conductive hearing loss	disease	HPO
C0019163	Hepatitis B	disease	BEFREE
C0019189	Hepatitis, Chronic	disease	BEFREE
C0019207	Hepatoma, Morris	disease	CTD_human
C0019208	Hepatoma, Novikoff	disease	CTD_human
C0020507	Hyperplasia	phenotype	LHGDN
C0020534	Orbital separation excessive	phenotype	HPO
C0020608	Hypodontia	disease	HPO
C0021367	Mammary Ductal Carcinoma	disease	CTD_human
C0021368	Inflammation	phenotype	LHGDN
C0022104	Irritable Bowel Syndrome	disease	BEFREE
C0022650	Kidney Calculi	disease	BEFREE
C0022665	Kidney Neoplasm	disease	BEFREE
C0022790	Krukenberg Tumor	disease	BEFREE
C0023055	Laryngeal neoplasm	disease	LHGDN
C0023269	leiomyosarcoma	disease	BEFREE
C0023418	leukemia	disease	BEFREE
C0023434	Chronic Lymphocytic Leukemia	disease	BEFREE
C0023467	Leukemia, Myelocytic, Acute	disease	BEFREE
C0023473	Myeloid Leukemia, Chronic	disease	BEFREE
C0023890	Liver Cirrhosis	disease	BEFREE
C0023904	Liver Neoplasms, Experimental	group	CTD_human
C0024121	Lung Neoplasms	group	BEFREE;LHGDN
C0024232	Lymphatic Metastasis	disease	LHGDN
C0024299	Lymphoma	group	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE;CGI;CTD_human;UNIPROT
C0024667	Animal Mammary Neoplasms	group	CTD_human
C0024668	Mammary Neoplasms, Experimental	group	CTD_human
C0025149	Medulloblastoma	disease	BEFREE
C0025202	melanoma	disease	BEFREE;GWASCAT;LHGDN
C0025286	Meningioma	disease	BEFREE;LHGDN
C0025500	Mesothelioma	disease	CTD_human
C0025568	Metaplasia	phenotype	LHGDN
C0026470	Monoclonal Gammopathy of Undetermined Significance	disease	BEFREE
C0026764	Multiple Myeloma	disease	BEFREE
C0026936	Mycoplasma Infections	group	CTD_human
C0027439	Nasopharyngeal Neoplasms	group	GWASDB
C0027626	Neoplasm Invasiveness	phenotype	CTD_human
C0027627	Neoplasm Metastasis	phenotype	BEFREE;CTD_human;LHGDN
C0027645	Neoplasm Seeding	phenotype	CTD_human
C0027659	Neoplasms, Experimental	group	CTD_human
C0027672	Neoplastic Syndromes, Hereditary	group	BEFREE;CLINVAR;LHGDN
C0027708	Nephroblastoma	disease	BEFREE
C0027746	Nerve Degeneration	phenotype	CTD_human
C0028259	Nodule	phenotype	BEFREE
C0028945	oligodendroglioma	disease	BEFREE
C0029925	Ovarian Carcinoma	disease	BEFREE;UNIPROT
C0030186	Paget Disease Extramammary	disease	BEFREE;LHGDN
C0030297	Pancreatic Neoplasm	disease	CTD_human;LHGDN
C0030809	Pemphigus Vulgaris	disease	BEFREE
C0032000	Pituitary Adenoma	disease	BEFREE
C0032019	Pituitary Neoplasms	group	LHGDN
C0032580	Adenomatous Polyposis Coli	disease	BEFREE;LHGDN
C0032584	polyps	phenotype	BEFREE
C0032927	Precancerous Conditions	group	BEFREE;CTD_human
C0033036	Atrial Premature Complexes	disease	BEFREE
C0033375	Prolactinoma	disease	LHGDN
C0033578	Prostatic Neoplasms	group	BEFREE;CTD_human;LHGDN
C0033822	Pseudomyxoma Peritonei	disease	LHGDN
C0034069	Pulmonary Fibrosis	disease	RGD
C0034885	Rectal Neoplasms	group	LHGDN
C0036095	Salivary Gland Neoplasms	group	CTD_human
C0038356	Stomach Neoplasms	group	BEFREE;CGI;CTD_human;LHGDN
C0039101	synovial sarcoma	disease	BEFREE;LHGDN
C0040100	Thymoma	disease	BEFREE
C0040136	Thyroid Neoplasm	disease	BEFREE;LHGDN
C0041582	Ulcer	disease	BEFREE
C0042769	Virus Diseases	group	BEFREE
C0042900	Vitiligo	disease	BEFREE
C0079487	Helicobacter Infections	group	CTD_human
C0079731	B-Cell Lymphomas	group	BEFREE
C0079740	High Grade Lymphoma (neoplasm)	disease	BEFREE
C0079744	Diffuse Large B-Cell Lymphoma	disease	BEFREE
C0085390	Li-Fraumeni Syndrome	disease	BEFREE
C0085694	Chronic cholecystitis	disease	BEFREE
C0086404	Experimental Hepatoma	disease	CTD_human
C0149678	Epstein-Barr Virus Infections	group	BEFREE
C0149925	Small cell carcinoma of lung	disease	BEFREE
C0151779	Cutaneous Melanoma	disease	GWASCAT
C0152013	Adenocarcinoma of lung (disorder)	disease	BEFREE
C0152018	Esophageal carcinoma	disease	BEFREE
C0153381	Malignant neoplasm of mouth	disease	BEFREE
C0153392	Malignant neoplasm of nasopharynx	disease	BEFREE
C0153452	Malignant neoplasm of gallbladder	disease	BEFREE
C0153690	Secondary malignant neoplasm of bone	disease	BEFREE
C0153943	Benign neoplasm of stomach	disease	CGI
C0154060	Carcinoma in situ of stomach	disease	CGI
C0156344	Endometriosis of ovary	disease	BEFREE
C0158646	Cleft palate with cleft lip	disease	BEFREE;ORPHANET
C0178874	Tumor Progression	phenotype	BEFREE
C0205696	Anaplastic carcinoma	disease	CTD_human
C0205697	Carcinoma, Spindle-Cell	disease	CTD_human
C0205698	Undifferentiated carcinoma	phenotype	CTD_human
C0205699	Carcinomatosis	phenotype	CTD_human
C0205945	Sarcoma, Spindle Cell	disease	BEFREE
C0206161	Reticulocyte count (procedure)	phenotype	GWASCAT
C0206684	Sebaceous Adenocarcinoma	disease	BEFREE
C0206687	Carcinoma, Endometrioid	disease	LHGDN
C0206692	Carcinoma, Lobular	disease	BEFREE;CGI;CTD_human;LHGDN;UNIPROT
C0206694	Mucoepidermoid Carcinoma	disease	BEFREE;LHGDN
C0206696	Carcinoma, Signet Ring Cell	disease	BEFREE;LHGDN
C0206698	Cholangiocarcinoma	disease	LHGDN
C0206706	Verrucous carcinoma	disease	BEFREE
C0206715	Neoplasms, Neuroepithelial	group	LHGDN
C0220636	Malignant neoplasm of salivary gland	disease	CTD_human
C0220641	Lip and Oral Cavity Carcinoma	disease	BEFREE
C0220650	Metastatic malignant neoplasm to brain	disease	BEFREE
C0220668	Congenital contractural arachnodactyly	disease	BEFREE
C0221352	Syndactyly of fingers	disease	HPO
C0235874	Disease Exacerbation	phenotype	CTD_human
C0235974	Pancreatic carcinoma	disease	BEFREE
C0238198	Gastrointestinal Stromal Tumors	group	BEFREE;CGI
C0238301	Cancer of Nasopharynx	disease	BEFREE
C0238339	Hereditary pancreatitis	disease	BEFREE
C0238463	Papillary thyroid carcinoma	disease	BEFREE
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0242647	Mucosa-Associated Lymphoid Tissue Lymphoma	disease	BEFREE
C0262984	Spongiotic dermatitis	disease	BEFREE
C0263523	Micronychia (disorder)	phenotype	HPO
C0264408	Childhood asthma	disease	BEFREE
C0265610	Congenital clinodactyly	disease	HPO
C0266037	Peg-shaped teeth	disease	HPO
C0268398	Familial lichen amyloidosis	disease	BEFREE
C0278488	Carcinoma breast stage IV	disease	BEFREE
C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	disease	BEFREE
C0279563	Lobular carcinoma in situ of breast	disease	BEFREE
C0279565	Invasive Lobular Breast Carcinoma	disease	BEFREE
C0279607	Adult Hepatocellular Carcinoma	disease	RGD
C0279626	Squamous cell carcinoma of esophagus	disease	BEFREE
C0279628	Adenocarcinoma Of Esophagus	disease	BEFREE
C0279671	Cervical Squamous Cell Carcinoma	disease	BEFREE
C0279672	Cervical Adenocarcinoma	disease	BEFREE
C0279680	Transitional cell carcinoma of bladder	disease	BEFREE
C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	disease	BEFREE
C0280100	Solid Neoplasm	phenotype	BEFREE
C0282313	Condition, Preneoplastic	phenotype	CTD_human
C0282612	Prostatic Intraepithelial Neoplasias	disease	CTD_human
C0302592	Cervix carcinoma	disease	BEFREE
C0334245	Intraepithelial Squamous Cell Carcinoma	disease	BEFREE
C0334287	Fibrolamellar Hepatocellular Carcinoma	disease	BEFREE
C0334357	Papillary cystic tumor	disease	BEFREE
C0334381	Non-infiltrating lobular carcinoma	disease	BEFREE
C0338106	Adenocarcinoma of colon	disease	BEFREE
C0338508	Optic Atrophy, Autosomal Dominant	disease	BEFREE
C0345904	Malignant neoplasm of liver	disease	BEFREE
C0345905	Intrahepatic Cholangiocarcinoma	disease	BEFREE
C0345967	Malignant mesothelioma	disease	BEFREE
C0346153	Breast Cancer, Familial	disease	GENOMICS_ENGLAND
C0346629	Malignant neoplasm of large intestine	disease	BEFREE
C0346647	Malignant neoplasm of pancreas	disease	BEFREE;CTD_human
C0349532	Gastric lymphoma	disease	BEFREE
C0349566	Squamous cell carcinoma of tongue	disease	BEFREE
C0369183	Erythrocyte Mean Corpuscular Hemoglobin Test	phenotype	GWASCAT
C0376358	Malignant neoplasm of prostate	disease	BEFREE;CTD_human
C0376545	Hematologic Neoplasms	group	BEFREE
C0392525	Nephrolithiasis	disease	BEFREE
C0423848	Distichiasis	phenotype	HPO
C0424295	Hyperactive behavior	phenotype	BEFREE
C0476089	Endometrial Carcinoma	disease	BEFREE;CTD_human;HPO
C0496905	Neoplasm of uncertain or unknown behavior of stomach	disease	CGI
C0521736	Lower eyelid ectropion	phenotype	HPO
C0524587	Mean Corpuscular Volume (result)	phenotype	GWASCAT
C0524909	Hepatitis B, Chronic	disease	BEFREE
C0546837	Malignant neoplasm of esophagus	disease	BEFREE
C0549473	Thyroid carcinoma	disease	BEFREE;UNIPROT
C0553573	Primary infertility	disease	BEFREE
C0558355	Tonsillar Carcinoma	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0598766	Leukemogenesis	disease	BEFREE
C0598935	Tumor Initiation	phenotype	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0677886	Epithelial ovarian cancer	disease	BEFREE;UNIPROT
C0678222	Breast Carcinoma	disease	BEFREE;CTD_human;HPO
C0684249	Carcinoma of lung	disease	BEFREE
C0685938	Malignant neoplasm of gastrointestinal tract	disease	BEFREE
C0686619	Secondary malignant neoplasm of lymph node	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE;CGI;HPO;UNIPROT
C0699885	Carcinoma of bladder	disease	BEFREE
C0740457	Malignant neoplasm of kidney	disease	BEFREE
C0750952	Biliary Tract Cancer	disease	BEFREE
C0751396	Well Differentiated Oligodendroglioma	disease	BEFREE
C0751560	Malignant neoplasm tonsil	disease	BEFREE
C0810364	Cleft Lip with or without Cleft Palate	disease	BEFREE
C0850666	Infection caused by Helicobacter pylori	disease	BEFREE
C0851140	Carcinoma in situ of uterine cervix	disease	BEFREE
C0853879	Invasive carcinoma of breast	disease	BEFREE
C0858252	Breast adenocarcinoma	disease	BEFREE
C0861352	Lobular Neoplasia	disease	BEFREE
C0919267	ovarian neoplasm	disease	CTD_human;LHGDN
C0936223	Metastatic Prostate Carcinoma	disease	BEFREE
C0940937	precancerous lesions	phenotype	BEFREE
C0948209	Intestinal adenocarcinoma	disease	BEFREE
C0948216	Ovarian adenocarcinoma	disease	BEFREE
C0948380	Colorectal cancer metastatic	disease	BEFREE
C0948750	Salivary gland carcinoma	disease	BEFREE
C0949541	Hurthle Cell Tumor	disease	BEFREE
C1112155	Hereditary non-polyposis colorectal cancer syndrome	disease	CLINGEN
C1134719	Invasive Ductal Breast Carcinoma	disease	BEFREE;CTD_human
C1140680	Malignant neoplasm of ovary	disease	BEFREE;CLINGEN;CTD_human
C1168401	Squamous cell carcinoma of the head and neck	disease	BEFREE
C1176475	Ductal Carcinoma	disease	BEFREE;LHGDN
C1257925	Mammary Carcinoma, Animal	disease	CTD_human
C1257931	Mammary Neoplasms, Human	group	CTD_human
C1261502	Finding of Mean Corpuscular Hemoglobin	phenotype	GWASCAT
C1275122	Familial multiple trichoepitheliomata	disease	BEFREE
C1275217	Paget's disease of vulva	disease	BEFREE
C1282496	Metastasis from malignant tumor of prostate	disease	BEFREE
C1302401	Adenoma of large intestine	disease	BEFREE
C1303001	Congenital euryblepharon	disease	HPO
C1306214	ACTH-Secreting Pituitary Adenoma	disease	BEFREE
C1306459	Primary malignant neoplasm	group	BEFREE
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1306837	Papillary Renal Cell Carcinoma	disease	BEFREE
C1319315	Adenocarcinoma of large intestine	disease	GWASDB
C1333600	Hereditary Malignant Neoplasm	group	BEFREE
C1333977	Hepatitis B Virus-Related Hepatocellular Carcinoma	disease	BEFREE
C1333990	Hereditary Nonpolyposis Colorectal Cancer	disease	BEFREE;CLINGEN
C1334274	Invasive Carcinoma	phenotype	BEFREE
C1335302	Pancreatic Ductal Adenocarcinoma	disease	BEFREE
C1335483	Gastric Diffuse Large B-Cell Lymphoma	disease	BEFREE
C1335965	Signet-ring cell adenocarcinoma gastric	disease	BEFREE
C1336076	Sporadic Breast Carcinoma	disease	BEFREE
C1336527	Carcinoma of urinary bladder, superficial	disease	BEFREE
C1367654	Marginal Zone B-Cell Lymphoma	disease	BEFREE
C1368683	Epithelioma	disease	BEFREE
C1378050	Oncocytic Neoplasm	disease	BEFREE
C1378703	Renal carcinoma	disease	BEFREE
C1398522	Cleft palate and bilateral cleft lip	disease	HPO
C1449563	Cardiomyopathy, Familial Idiopathic	disease	BEFREE
C1458155	Mammary Neoplasms	group	BEFREE;CTD_human;LHGDN
C1510502	Oxyphilic Adenoma	disease	BEFREE
C1512409	Hepatocarcinogenesis	disease	BEFREE
C1527249	Colorectal Cancer	disease	BEFREE;CTD_human;GWASCAT
C1611743	Familial (FPAH)	disease	BEFREE
C1623038	Cirrhosis	disease	BEFREE
C1706827	Apocrine Carcinoma	disease	BEFREE
C1708349	Hereditary Diffuse Gastric Cancer	disease	BEFREE;CLINGEN;CLINVAR;CTD_human;ORPHANET;UNIPROT
C1762616	Meningioma, benign, no ICD-O subtype	disease	BEFREE
C1847835	VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	disease	BEFREE
C1850900	Familial primary gastric lymphoma	disease	BEFREE
C1851841	ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1	disease	BEFREE
C1861536	Blepharo-cheilo-dontic syndrome	disease	BEFREE;CLINVAR;ORPHANET;UNIPROT
C1861537	OROFACIAL CLEFT 1	disease	BEFREE
C1883486	Uterine Corpus Cancer	disease	BEFREE
C1997217	Low grade glioma	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE;LHGDN
C2931456	Prostate cancer, familial	disease	BEFREE;CTD_human
C2931822	Nasopharyngeal carcinoma	disease	BEFREE
C2987191	Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type	disease	BEFREE
C3149287	GASTRIC CANCER, FAMILIAL DIFFUSE, AND CLEFT LIP WITH OR WITHOUT CLEFT PALATE	disease	CLINGEN;UNIPROT
C3463824	MYELODYSPLASTIC SYNDROME	group	BEFREE
C3469521	FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	disease	BEFREE
C3539878	Triple Negative Breast Neoplasms	disease	BEFREE
C3549742	Breast cancer, lobular	disease	BEFREE;CLINGEN;UNIPROT
C3642346	Luminal B Breast Carcinoma	disease	BEFREE
C3647143	Secondary malignant neoplasm of ovary	disease	BEFREE
C3665419	intracranial glioma	disease	BEFREE
C3714514	Infection	group	LHGDN
C3714941	OTOFACIOCERVICAL SYNDROME 1	disease	BEFREE
C3805278	Extrahepatic Cholangiocarcinoma	disease	BEFREE
C3839868	Cytogenetically normal acute myeloid leukemia	disease	BEFREE
C4012359	Pointed tooth	phenotype	HPO
C4020808	Everted lower eyelids	phenotype	HPO
C4021768	Abnormality of metabolism/homeostasis	group	HPO
C4024979	Ovarian papillary adenocarcinoma	disease	HPO
C4025846	Abnormality of vision	phenotype	HPO
C4048328	cervical cancer	disease	BEFREE
C4280304	Curvature of digit	phenotype	HPO
C4280305	Kabuki syndrome eyelids	phenotype	HPO
C4280623	Rotting teeth	phenotype	HPO

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005509	calcium ion binding	IBA
GO:0005515	protein binding	IPI
GO:0008013	beta-catenin binding	IDA
GO:0008092	cytoskeletal protein binding	IBA
GO:0030506	ankyrin binding	IPI
GO:0032794	GTPase activating protein binding	IPI
GO:0042802	identical protein binding	IPI
GO:0042803	protein homodimerization activity	IBA
GO:0045295	gamma-catenin binding	IPI
GO:0045296	cadherin binding	IBA
GO:0045296	cadherin binding	HDA
GO:0050839	cell adhesion molecule binding	NAS
GO:0050839	cell adhesion molecule binding	IPI

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000902	cell morphogenesis	IBA
GO:0007043	cell-cell junction assembly	IBA
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	NAS
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	IBA
GO:0007275	multicellular organism development	IBA
GO:0007416	synapse assembly	IBA
GO:0009636	response to toxic substance	IEA
GO:0010468	regulation of gene expression	IMP
GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
GO:0021983	pituitary gland development	IEA
GO:0022408	negative regulation of cell-cell adhesion	IMP
GO:0030198	extracellular matrix organization	TAS
GO:0030336	negative regulation of cell migration	IMP
GO:0031175	neuron projection development	IEA
GO:0034332	adherens junction organization	IMP
GO:0034332	adherens junction organization	IBA
GO:0034332	adherens junction organization	TAS
GO:0035635	entry of bacterium into host cell	TAS
GO:0042307	positive regulation of protein import into nucleus	IDA
GO:0044331	cell-cell adhesion mediated by cadherin	IBA
GO:0045893	positive regulation of transcription, DNA-templated	IDA
GO:0071285	cellular response to lithium ion	IDA
GO:0071681	cellular response to indole-3-methanol	IDA
GO:0072659	protein localization to plasma membrane	IDA
GO:0072659	protein localization to plasma membrane	IMP
GO:0098609	cell-cell adhesion	IDA
GO:0098609	cell-cell adhesion	IBA
GO:0099576	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	TAS
GO:0005737	cytoplasm	IBA
GO:0005768	endosome	IEA
GO:0005802	trans-Golgi network	IMP
GO:0005886	plasma membrane	IBA
GO:0005886	plasma membrane	IDA
GO:0005886	plasma membrane	TAS
GO:0005912	adherens junction	IDA
GO:0005912	adherens junction	IBA
GO:0009898	cytoplasmic side of plasma membrane	IDA
GO:0009986	cell surface	IBA
GO:0015629	actin cytoskeleton	IDA
GO:0016021	integral component of membrane	IDA
GO:0016328	lateral plasma membrane	IDA
GO:0016342	catenin complex	IDA
GO:0016342	catenin complex	IBA
GO:0016600	flotillin complex	IBA
GO:0016600	flotillin complex	IDA
GO:0030027	lamellipodium	IDA
GO:0030054	cell junction	TAS
GO:0030054	cell junction	IDA
GO:0043296	apical junction complex	IDA
GO:0043296	apical junction complex	IBA
GO:0048471	perinuclear region of cytoplasm	IDA
GO:0070062	extracellular exosome	HDA
GO:0098794	postsynapse	IEA
GO:0098978	glutamatergic synapse	IEA
GO:0030864	cortical actin cytoskeleton	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-111465	Apoptotic cleavage of cellular proteins	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474228	Degradation of the extracellular matrix	IEA
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1500931	Cell-Cell communication	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-168256	Immune System	IEA
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	IEA
R-HSA-216083	Integrin cell surface interactions	TAS
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	TAS
R-HSA-418990	Adherens junctions interactions	TAS
R-HSA-421270	Cell-cell junction organization	TAS
R-HSA-446728	Cell junction organization	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-5626467	RHO GTPases activate IQGAPs	TAS
R-HSA-5663205	Infectious disease	TAS
R-HSA-75153	Apoptotic execution phase	TAS
R-HSA-8876384	Listeria monocytogenes entry into host cells	TAS
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C504897	12-(3-adamantan-1-ylureido)dodecanoic acid	12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]	28694203
C504897	12-(3-adamantan-1-ylureido)dodecanoic acid	12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	28694203
C504897	12-(3-adamantan-1-ylureido)dodecanoic acid	12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]	28694203
C504897	12-(3-adamantan-1-ylureido)dodecanoic acid	12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]	28694203
C026486	1,2,5,6-dibenzanthracene	1,2,5,6-dibenzanthracene results in decreased expression of CDH1 mRNA	26377693
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]	18791180
C569107	1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one	1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of CDH1 protein	21903591
D014013	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]	22648416
D019813	1,2-Dimethylhydrazine	[Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of CDH1 mRNA	29269057
C532657	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]	26685284
C532657	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one	[N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester co-treated with 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one] inhibits the reaction [polyhexamethyleneguanidine results in decreased expression of CDH1 protein]	31348943
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CDH1 protein	21705713
D020001	1-Butanol	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
C032668	1-nitropyrene	1-nitropyrene results in decreased expression of CDH1 mRNA	19041380
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]	30517707
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]	19593637
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]	19593637
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in decreased expression of CDH1 protein]	22573546
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased expression of CDH1 protein]	27474067
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]	25656647
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CDH1 protein	22573546
C120227	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [hydroxyflutamide results in increased phosphorylation of CDH1 protein]	28163245
C573693	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of CDH1 mRNA	22193206
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CDH1 protein	19464575
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CDH1 protein]	19464575
D015085	2,4,5-Trichlorophenoxyacetic Acid	2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CDH1 mRNA	18579281
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in increased expression of CDH1 mRNA	29108245
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	TLN1 protein inhibits the reaction [2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in increased expression of CDH1 mRNA]	29108245
C121479	2,4-dihydroxybenzophenone	2,4-dihydroxybenzophenone results in decreased expression of CDH1 protein	27145024
C121479	2,4-dihydroxybenzophenone	Fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in decreased expression of CDH1 protein]	27145024
C045305	2,4-dinitrofluorobenzene sulfonic acid	2,4-dinitrofluorobenzene sulfonic acid results in increased expression of CDH1 mRNA	17936526
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]	26363213
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]	25118938
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in decreased expression of CDH1 protein]	27856280
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]	25656647
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDH1 protein	23921149
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]	26089345
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene affects the expression of CDH1 mRNA	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDH1 protein	22307971
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDH1 protein]	22307971
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDH1 protein	22581815
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of CDH1 mRNA	25088246
C029216	2-amino-3-methylimidazo(4,5-f)quinoline	2-amino-3-methylimidazo(4,5-f)quinoline results in decreased expression of CDH1 protein	22094457
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	[2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of CDH1 protein	20348013
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]	27989784
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in increased expression of CDH1 protein	27989784
C040668	2-ethylhexanoic acid	2-ethylhexanoic acid results in increased expression of CDH1 mRNA	30578912
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDH1 mRNA]	29704546
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]	28844962
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]	28844962
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]	28844962
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	PKM protein promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	WP1066 inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]	28284859
C497286	3,4',5-trimethoxystilbene	3,4',5-trimethoxystilbene promotes the reaction [Tamoxifen results in increased expression of CDH1 protein]	23921149
C497286	3,4',5-trimethoxystilbene	3,4',5-trimethoxystilbene results in increased expression of CDH1 mRNA	23921149
C497286	3,4',5-trimethoxystilbene	3,4',5-trimethoxystilbene results in increased expression of CDH1 protein	23921149
C497286	3,4',5-trimethoxystilbene	Tamoxifen promotes the reaction [3,4',5-trimethoxystilbene results in increased expression of CDH1 protein]	23921149
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CDH1 mRNA	16788091
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]	25656647
C494914	3,5,3',4',5'-pentamethoxystilbene	3,5,3',4',5'-pentamethoxystilbene results in increased expression of CDH1 protein	23921149
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	3,5-bis(2-fluorobenzylidene)piperidin-4-one results in increased expression of CDH1 protein	25725129
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	HMGA2 protein inhibits the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in increased expression of CDH1 protein]	25725129
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	MIR33B mRNA affects the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in increased expression of CDH1 protein]	25725129
C048460	3-deazaneplanocin	3-deazaneplanocin results in increased expression of CDH1 protein	21114963
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]	19015640
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Cyclosporine results in decreased expression of CDH1 protein]	22416070
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	22573546
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C108123	4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine	4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine results in increased expression of CDH1 protein	25856345
C045934	4-hydroxy-2-hexenal	4-hydroxy-2-hexenal results in decreased expression of CDH1 mRNA	28760545
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDH1 protein	30236600
C002202	4-oxoretinoic acid	4-oxoretinoic acid affects the expression of CDH1 mRNA	17034753
C041819	4-oxoretinol	4-oxoretinol affects the expression of CDH1 mRNA	17034753
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of CDH1 protein	27145024
C105260	4-tert-octylphenol	Fulvestrant inhibits the reaction [4-tert-octylphenol results in decreased expression of CDH1 protein]	27145024
C508504	6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride	6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	28694203
C584755	6-bromo-8-ethoxy-3-nitro-2H-chromene	6-bromo-8-ethoxy-3-nitro-2H-chromene results in increased expression of CDH1 protein	30125547
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]	31472180
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]]	31472180
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CDH1 mRNA	29663660
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CDH1 protein	29663660
C496492	abrine	abrine results in decreased expression of CDH1 mRNA	31054353
D000082	Acetaminophen	Acetaminophen results in decreased expression of CDH1 mRNA	21420995; 26690555; 29067470;
D000082	Acetaminophen	Acetaminophen affects the expression of CDH1 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]	28284859
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]	18791180
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]	24820114
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]	22648416
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [nickel chloride results in increased methylation of CDH1 promoter]	22648416
D000181	Acrylonitrile	Acrylonitrile results in decreased expression of CDH1 protein	30236600
D000336	Aerosols	Aerosols results in decreased expression of CDH1 mRNA	29505817
C016601	afimoxifene	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]	19593637
C016601	afimoxifene	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]	19593637
C016601	afimoxifene	[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 mRNA	19593637
C016601	afimoxifene	[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein	19593637
C016601	afimoxifene	afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]	19593637
C016601	afimoxifene	afimoxifene results in increased expression of CDH1 mRNA	19593637
C016601	afimoxifene	afimoxifene results in increased expression of CDH1 protein	19593637
C016601	afimoxifene	AG 1879 inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]	19593637
C016601	afimoxifene	AG 1879 inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]	19593637
C016601	afimoxifene	Fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]	19593637
C016601	afimoxifene	Fulvestrant inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]	19593637
C016601	afimoxifene	Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]]	19593637
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CDH1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CDH1 mRNA	22100608; 27153756; 28943387;
C412373	AG 1879	AG 1879 inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]	19593637
C412373	AG 1879	AG 1879 inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]	19593637
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of CDH1 mRNA	21757418
D000450	Aldosterone	Aldosterone results in decreased expression of CDH1 mRNA	17596522
D000450	Aldosterone	Aldosterone results in decreased expression of CDH1 protein	17596522
D000450	Aldosterone	Eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]	17596522
D000450	Aldosterone	Eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]	17596522
D000450	Aldosterone	Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]	17596522
D000450	Aldosterone	Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]	17596522
D000450	Aldosterone	U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]	17596522
D000450	Aldosterone	U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]	17596522
D000452	Aldrin	Aldrin results in increased expression of CDH1 mRNA	18579281
C526957	alisol B 23-acetate	alisol B 23-acetate inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]	28578904
D000077556	Alitretinoin	Alitretinoin affects the expression of CDH1 mRNA	17034753
D000493	Allopurinol	Allopurinol inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]	22648416
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin affects the methylation of CDH1 promoter	27884059
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of CDH1 mRNA	28522335
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of CDH1 mRNA	21298039
C100057	ametryne	ametryne results in decreased expression of CDH1 mRNA	26310382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CDH1 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of CDH1 protein	16483693
C030419	andrographolide	andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]	31128153
C030419	andrographolide	IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]]	31128153
D000872	Anthocyanins	Anthocyanins inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]	30403199
C545357	antroquinonol	antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]	25656647
C004984	apocarotenal	apocarotenal results in increased expression of CDH1 mRNA	17034753
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of CDH1 mRNA	25663515
C000228	aristolochic acid I	aristolochic acid I results in decreased expression of CDH1 mRNA	31048001
C000228	aristolochic acid I	aristolochic acid I results in decreased expression of CDH1 protein	31048001
C000228	aristolochic acid I	GREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of CDH1 protein]	22525892
C000228	aristolochic acid I	aristolochic acid I results in decreased expression of CDH1 protein	22525892
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of CDH1 mRNA	25663515
D034341	Aristolochic Acids	Aristolochic Acids results in decreased expression of CDH1 protein	20696222
D034341	Aristolochic Acids	[Aristolochic Acids results in increased secretion of TGFB1 protein] which results in decreased expression of CDH1 protein	20696222
D034341	Aristolochic Acids	BMP7 protein inhibits the reaction [Aristolochic Acids results in decreased expression of CDH1 protein]	20696222
D001151	Arsenic	Arsenic affects the methylation of CDH1 promoter	30220071
D001151	Arsenic	DNMT3B gene SNP affects the reaction [Arsenic affects the methylation of CDH1 promoter]	30220071
D000077237	Arsenic Trioxide	Arsenic Trioxide promotes the reaction [Decitabine results in increased expression of CDH1 mRNA]	16613325
D000077237	Arsenic Trioxide	Arsenic Trioxide promotes the reaction [Tretinoin results in increased expression of CDH1 mRNA]	30093655
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of CDH1 mRNA	23851143
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of CDH1 protein	29396848
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased methylation of CDH1 promoter	16613325; 23104537;
D000077237	Arsenic Trioxide	[Arsenic Trioxide results in decreased methylation of CDH1 promoter] which results in increased expression of CDH1 mRNA	23104537; 23104537;
D000077237	Arsenic Trioxide	[Arsenic Trioxide results in decreased methylation of CDH1 promoter] which results in increased expression of CDH1 protein	23104537; 23104537;
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of and affects the localization of CDH1 protein	16613325
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of CDH1 mRNA	16613325; 30093655;
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of CDH1 protein	17512576; 24680928; 29409467;
D000077237	Arsenic Trioxide	Decitabine promotes the reaction [Arsenic Trioxide results in increased expression of CDH1 mRNA]	16613325
D000077237	Arsenic Trioxide	GH1 protein promotes the reaction [Arsenic Trioxide results in decreased expression of CDH1 mRNA]	23851143
D000077237	Arsenic Trioxide	MIR491 mRNA affects the reaction [Arsenic Trioxide results in increased expression of CDH1 protein]	24680928
D000077237	Arsenic Trioxide	pervanadate inhibits the reaction [Arsenic Trioxide results in increased expression of CDH1 protein]	29409467
D000077237	Arsenic Trioxide	Tretinoin promotes the reaction [Arsenic Trioxide results in increased expression of CDH1 mRNA]	30093655
C015001	arsenite	arsenite results in decreased expression of CDH1 protein	17373649
C015001	arsenite	arsenite results in decreased expression of CDH1 protein	21344382
D017638	Asbestos, Crocidolite	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in decreased expression of CDH1 protein]	22573546
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in decreased expression of CDH1 mRNA	18687144; 24160326;
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in decreased expression of CDH1 protein	22573546; 24160326;
D017632	Asbestos, Serpentine	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]	26685284
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in decreased expression of CDH1 mRNA	24160326; 26685284;
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in decreased expression of CDH1 protein	24160326; 26685284;
D017632	Asbestos, Serpentine	SB 216763 inhibits the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]	26685284
D017632	Asbestos, Serpentine	TGFB1 protein affects the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]	26685284
D001241	Aspirin	Aspirin affects the methylation of CDH1 promoter	19184424
D001374	Azacitidine	Azacitidine results in decreased methylation of CDH1 promoter	17520682
D001374	Azacitidine	Azacitidine results in increased expression of CDH1 mRNA	17520682
C406592	azaspiracid	azaspiracid results in decreased uptake of CDH1 protein modified form	20547569
C406592	azaspiracid	azaspiracid results in increased expression of CDH1 protein modified form	17118960
D001397	Azoxymethane	Azoxymethane results in decreased expression of CDH1 protein	20681671
D001397	Azoxymethane	pterostilbene inhibits the reaction [Azoxymethane results in decreased expression of CDH1 protein]	20681671
D001397	Azoxymethane	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CDH1 mRNA	29950665
D001397	Azoxymethane	Azoxymethane results in increased expression of CDH1 protein	12496057
D001397	Azoxymethane	Ro 24-5531 inhibits the reaction [Azoxymethane results in increased expression of CDH1 protein]	12496057
D001397	Azoxymethane	Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of CDH1 protein]	12496057
C487081	belinostat	belinostat results in increased expression of CDH1 mRNA	26272509
C487081	belinostat	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of CDH1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of CDH1 mRNA	20106945
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CDH1 mRNA	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of CDH1 mRNA	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CDH1 mRNA	21632981; 22178795; 22316170; 26238291; 27221058; 30659931; 31255691;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CDH1 protein	27221058; 30659931;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CDH1 protein	26359795
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CDH1 mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CDH1 mRNA	19770486; 21803694;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CDH1 mRNA	21839799
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CDH1 protein	21467743
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of CDH1 mRNA	17690111
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of CDH1 mRNA	23117580
D019207	beta Carotene	beta Carotene results in increased expression of CDH1 mRNA	17034753
D019207	beta Carotene	beta Carotene results in increased expression of CDH1 protein	26733226
C053541	bicalutamide	bicalutamide affects the localization of CDH1 protein	17440980
D001688	Biological Products	Biological Products results in decreased expression of CDH1 protein	23624380
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of CDH1 mRNA	30265984
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of CDH1 protein	28808208
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased methylation of CDH1 promoter	30616060
C543008	bis(4-hydroxyphenyl)sulfone	Fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CDH1 protein]	28808208
C543008	bis(4-hydroxyphenyl)sulfone	[bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of CDH1 mRNA	30951980
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of CDH1 mRNA	30951980
C006780	bisphenol A	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]	26363213
C006780	bisphenol A	3,3'-diindolylmethane inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]	28844962
C006780	bisphenol A	bisphenol A results in decreased expression of CDH1 mRNA	26363213; 26546977;
C006780	bisphenol A	bisphenol A results in decreased expression of CDH1 protein	23391485; 25690688; 26363213; 26407941; 28808208; 28844962; 30611077;
C006780	bisphenol A	FOXA1 protein affects the reaction [bisphenol A results in decreased expression of CDH1 protein]	26363213
C006780	bisphenol A	Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]	25690688; 26407941; 28844962;
C006780	bisphenol A	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDH1 protein]	28808208
C006780	bisphenol A	Genistein inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]	26407941
C006780	bisphenol A	plerixafor octahydrochloride inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]	28844962
C006780	bisphenol A	bisphenol A affects the methylation of CDH1 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of CDH1 mRNA	26063408; 27480627;
C006780	bisphenol A	bisphenol A results in decreased expression of CDH1 protein	26026914; 27480627;
C006780	bisphenol A	bisphenol A results in increased expression of CDH1 mRNA	24769007
C006780	bisphenol A	bisphenol A results in increased expression of CDH1 protein	24769007
C006780	bisphenol A	SNAI1 protein promotes the reaction [bisphenol A results in decreased expression of CDH1 protein]	27480627
C006780	bisphenol A	bisphenol A affects the expression of CDH1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of CDH1 mRNA	25181051; 29323181; 30816183;
C006780	bisphenol A	bisphenol A results in decreased expression of CDH1 protein	29323181
C000611646	bisphenol F	bisphenol F results in decreased expression of CDH1 mRNA	30265984
C000611646	bisphenol F	bisphenol F results in decreased expression of CDH1 protein	28808208
C000611646	bisphenol F	Fulvestrant inhibits the reaction [bisphenol F results in increased expression of CDH1 protein]	28808208
C000611646	bisphenol F	[bisphenol F co-treated with Tretinoin] results in decreased expression of CDH1 mRNA	30951980
C000611646	bisphenol F	bisphenol F results in increased expression of CDH1 mRNA	30951980
C472645	blebbistatin	blebbistatin affects the localization of CDH1 protein	16030252
C472645	blebbistatin	blebbistatin results in decreased activity of CDH1 protein	16030252
D001761	Bleomycin	12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]	28694203
D001761	Bleomycin	12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]	28694203
D001761	Bleomycin	Bleomycin results in decreased expression of CDH1 mRNA	28300665; 28694203;
D001761	Bleomycin	Bleomycin results in decreased expression of CDH1 protein	28300665; 28694203;
D001761	Bleomycin	Dexamethasone inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]	28300665; 28694203;
D001761	Bleomycin	Dexamethasone inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]	28300665; 28694203;
D001761	Bleomycin	Grape Seed Extract inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]	28300665
D001761	Bleomycin	Grape Seed Extract inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]	28300665
C471992	bosutinib	bosutinib promotes the reaction [CTNNB1 protein binds to CDH1 protein]	16489032
C471992	bosutinib	CTNNB1 protein promotes the reaction [bosutinib results in increased stability of CDH1 protein]	16489032
C025191	bromodichloromethane	bromodichloromethane results in decreased expression of CDH1 mRNA	24001804
C025191	bromodichloromethane	bromodichloromethane results in decreased expression of CDH1 protein	24001804
C025191	bromodichloromethane	bromodichloromethane results in increased methylation of CDH1 gene	24001804
D002084	Butylated Hydroxytoluene	[Butylated Hydroxytoluene co-treated with Oxygen] results in decreased expression of CDH1 protein	16272459
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased expression of CDH1 protein	22552774
C018475	butyraldehyde	butyraldehyde results in decreased expression of CDH1 mRNA	26079696
D002087	Butyrates	Butyrates results in increased expression of CDH1 mRNA	16042588
C584509	C646 compound	C646 compound inhibits the reaction [Glucose results in decreased expression of CDH1 protein]	26045780
C584509	C646 compound	C646 compound results in increased expression of and affects the localization of CDH1 protein	26921506
C584509	C646 compound	C646 compound results in increased expression of CDH1 mRNA	26921506
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of CDH1 mRNA	16122865; 17481689;
D002104	Cadmium	Cadmium results in increased degradation of CDH1 protein	24798214
D002104	Cadmium	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium results in increased cleavage of CDH1 protein]	18791180
D002104	Cadmium	Cadmium results in increased expression of CDH1 mRNA	24084258
D002104	Cadmium	Cadmium affects the localization of CDH1 protein	23080431
D019256	Cadmium Chloride	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]	18791180
D019256	Cadmium Chloride	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]	25118938
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]	18791180
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CDH1 protein	25118938; 30998937;
D019256	Cadmium Chloride	Cadmium Chloride results in increased cleavage of CDH1 protein	18791180
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CDH1 mRNA	25882684
D019256	Cadmium Chloride	Cadmium Chloride results in increased secretion of CDH1 protein	18791180
D019256	Cadmium Chloride	Calcimycin promotes the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]	18791180
D019256	Cadmium Chloride	Hydrogen Peroxide promotes the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]	18791180
D019256	Cadmium Chloride	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased secretion of CDH1 protein]	18791180
D019256	Cadmium Chloride	NOTCH1 mutant form inhibits the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]	25118938
D019256	Cadmium Chloride	PSEN1 promotes the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]	18791180
D019256	Cadmium Chloride	SNAI1 mutant form inhibits the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]	25118938
D019256	Cadmium Chloride	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]	18791180
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [CTNNB1 protein binds to CDH1 protein binds to CTNNA1 protein]	20459685
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of and affects the localization of CDH1 protein	19615436
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CDH1 protein	15618353
D019256	Cadmium Chloride	CDH1 inhibits the reaction [Cadmium Chloride affects the localization of CTNNB1 protein]	20459685
D019256	Cadmium Chloride	CDH1 results in decreased susceptibility to Cadmium Chloride	20459685
D019256	Cadmium Chloride	N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]	15618353
D002110	Caffeine	Caffeine results in increased expression of CDH1 mRNA	20864626
D000001	Calcimycin	Calcimycin promotes the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]	18791180
D002117	Calcitriol	[Calcitriol binds to and results in increased activity of VDR protein] which results in increased expression of CDH1 mRNA	15489543
D002117	Calcitriol	Calcitriol results in increased expression of CDH1	16051482
D002117	Calcitriol	Calcitriol results in increased expression of CDH1 mRNA	26485663
D002117	Calcitriol	Calcitriol results in increased expression of CDH1 protein	11519864
D002220	Carbamazepine	Carbamazepine affects the expression of CDH1 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CDH1 mRNA	15056808; 27339419;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CDH1 protein	30254303
D002251	Carbon Tetrachloride	Carvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of CDH1 protein]	30254303
D002273	Carcinogens	Carcinogens results in increased expression of CDH1 mRNA	16316942
D002331	Carnitine	Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CDH1 protein]	28973641
D000077261	Carvedilol	Carvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of CDH1 protein]	30254303
D000068579	Celecoxib	Celecoxib affects the expression of CDH1 protein	17224647
D000068579	Celecoxib	Celecoxib analog results in increased expression of CDH1 protein	19682443
D000068579	Celecoxib	Celecoxib inhibits the reaction [SNAI1 protein binds to CDH1 promoter]	29932878
D000068579	Celecoxib	Celecoxib results in increased expression of CDH1 mRNA	29932878
D000068579	Celecoxib	Celecoxib results in increased expression of CDH1 protein	19682443; 29932878;
D007631	Chlordecone	Chlordecone inhibits the reaction [CDH1 protein binds to JUP protein]	11695219
D007631	Chlordecone	Chlordecone results in decreased expression of CDH1 protein	11695219
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CDH1 protein	27481218
D020111	Chlorodiphenyl (54% Chlorine)	MIR30D mRNA inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CDH1 protein]	27481218
D002726	Chlorogenic Acid	Chlorogenic Acid results in increased expression of CDH1 mRNA	20706672
C100187	chloropicrin	chloropicrin results in decreased expression of CDH1 mRNA	28476498
C100187	chloropicrin	chloropicrin results in increased expression of CDH1 mRNA	26352163
D002738	Chloroquine	Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]	30053495
D002738	Chloroquine	Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]	30053495
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of CDH1 mRNA	21356183
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDH1 protein	20548288
D002794	Choline	[[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIR155 mRNA] which results in increased expression of CDH1 protein	20548288
C074702	chromium hexavalent ion	CAT protein inhibits the reaction [chromium hexavalent ion results in decreased expression of CDH1 protein]	23518002
C074702	chromium hexavalent ion	chromium hexavalent ion promotes the reaction [HDAC1 protein binds to CDH1 promoter]	23518002
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of CDH1 mRNA	23518002
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of CDH1 protein	23518002; 27323401;
C074702	chromium hexavalent ion	trichostatin A inhibits the reaction [chromium hexavalent ion results in decreased expression of CDH1 protein]	23518002
C043561	chrysin	chrysin results in increased expression of CDH1 protein	24122885; 30578657;
C039671	ciglitazone	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of CDH1 mRNA	16197558
C039671	ciglitazone	[ciglitazone binds to PPARG protein] which results in increased expression of CDH1 mRNA	16197558
C039671	ciglitazone	ciglitazone results in increased expression of and results in increased activity of CDH1 protein	12391285
C039671	ciglitazone	ciglitazone results in decreased expression of CDH1 mRNA	22193206
D002922	Ciguatoxins	Ciguatoxins affects the expression of CDH1 mRNA	18353800
D002945	Cisplatin	[CDH1 protein binds to ENTPD6 protein] which results in decreased susceptibility to Cisplatin	21519793
D002945	Cisplatin	Cisplatin affects the expression of CDH1 mRNA	23300844
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in increased expression of CDH1 mRNA]	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of and results in decreased cleavage of CDH1 protein	21618587
D002945	Cisplatin	Cisplatin results in decreased expression of CDH1 mRNA	21618587
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in increased expression of CDH1 mRNA]	27392435
D002953	Citrinin	[Citrinin co-treated with ochratoxin A] results in decreased expression of CDH1 mRNA	29673704
D002953	Citrinin	[ochratoxin A co-treated with Citrinin] results in decreased expression of CDH1 protein	29673704
D002994	Clofibrate	Clofibrate affects the expression of CDH1 mRNA	16081524
D002994	Clofibrate	Clofibrate results in decreased expression of CDH1 mRNA	17585979
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CDH1 protein	26174737
C018021	cobaltous chloride	SLC31A1 mutant form inhibits the reaction [cobaltous chloride results in decreased expression of CDH1 protein]	26174737
C018021	cobaltous chloride	tetraethylenepentamine inhibits the reaction [cobaltous chloride results in decreased expression of CDH1 protein]	26174737
D003042	Cocaine	Cocaine results in decreased expression of CDH1 mRNA	12629581
D003078	Colchicine	Colchicine affects the activity of CDH1 protein	10413674
D005576	Colforsin	Colforsin affects the activity of CDH1 protein	10413674
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CDH1 mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in increased expression of CDH1 mRNA	18579281
D016578	Crack Cocaine	Crack Cocaine results in increased expression of CDH1 mRNA	12629581
C037886	cryptotanshinone	cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of CDH1 protein]	30208247
D003474	Curcumin	Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]	25656647
D003474	Curcumin	Curcumin results in increased expression of CDH1 protein	19573523
D003474	Curcumin	Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]	26191140
D003474	Curcumin	Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]	26191140
C038459	curdlan	curdlan results in decreased expression of CDH1 mRNA	23543010
C038459	curdlan	curdlan results in increased expression of CDH1 mRNA	23543010
C057862	cyanoginosin LR	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in decreased expression of CDH1 protein]	27856280
C057862	cyanoginosin LR	cyanoginosin LR results in decreased expression of CDH1 mRNA	27856280
C057862	cyanoginosin LR	cyanoginosin LR results in decreased expression of CDH1 protein	27856280
C057862	cyanoginosin LR	SMAD2 protein affects the reaction [cyanoginosin LR results in decreased expression of CDH1 protein]	27856280
D003520	Cyclophosphamide	Cyclophosphamide affects the expression of CDH1 mRNA	10859244
D016572	Cyclosporine	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Cyclosporine results in decreased expression of CDH1 protein]	22416070
D016572	Cyclosporine	Cyclosporine results in decreased expression of CDH1 mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in decreased expression of CDH1 protein	22416070
D016572	Cyclosporine	Cyclosporine results in decreased expression of CDH1 mRNA	22416070
D016572	Cyclosporine	Cyclosporine results in decreased expression of CDH1 protein	21354196; 22155090; 22416070;
D016572	Cyclosporine	Cyclosporine results in increased secretion of CDH1 protein	21354196
D016572	Cyclosporine	salubrinal inhibits the reaction [Cyclosporine results in decreased expression of CDH1 protein]	22155090
D016572	Cyclosporine	SNAI1 protein affects the reaction [Cyclosporine results in decreased expression of CDH1 protein]	22416070
D015638	Cytochalasin D	Cytochalasin D results in increased expression of CDH1 mRNA	25756282
D015638	Cytochalasin D	Cytochalasin D results in increased expression of CDH1 protein	25756282
D015638	Cytochalasin D	[Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein	25756282
D015638	Cytochalasin D	RHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein]	25756282
D003634	DDT	Acetylcysteine inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]	24820114
D003634	DDT	DDT inhibits the reaction [CDH1 protein binds to CTNNB1 protein]	22902829
D003634	DDT	DDT results in decreased expression of CDH1 mRNA	22902829; 24820114;
D003634	DDT	DDT results in decreased expression of CDH1 protein	22902829
D003634	DDT	INCB018424 inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]	24820114
D003634	DDT	WP1066 inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]	24820114
D000077209	Decitabine	Arsenic Trioxide promotes the reaction [Decitabine results in increased expression of CDH1 mRNA]	16613325
D000077209	Decitabine	Decitabine affects the expression of CDH1 mRNA	17194187; 23300844;
D000077209	Decitabine	Decitabine affects the methylation of CDH1 promoter	18584348
D000077209	Decitabine	[[Decitabine co-treated with trichostatin A] affects the acetylation of H3-4 protein] which affects the expression of CDH1 mRNA	18584348
D000077209	Decitabine	Decitabine inhibits the reaction [nickel chloride results in decreased expression of CDH1 mRNA]	22648416
D000077209	Decitabine	Decitabine inhibits the reaction [Smoke results in decreased expression of CDH1 mRNA]	21095227
D000077209	Decitabine	Decitabine inhibits the reaction [sodium arsenite results in decreased expression of CDH1 mRNA]	30191986
D000077209	Decitabine	Decitabine promotes the reaction [Arsenic Trioxide results in increased expression of CDH1 mRNA]	16613325
D000077209	Decitabine	Decitabine promotes the reaction [Vorinostat results in increased expression of CDH1 mRNA]	17417771
D000077209	Decitabine	Decitabine results in decreased methylation of CDH1 promoter	16613325; 18055864;
D000077209	Decitabine	Decitabine results in increased expression of CDH1 mRNA	16613325; 16887905; 18025290; 18974268; 30125549;
D000077209	Decitabine	Decitabine results in increased expression of CDH1 protein	16613325; 16887905; 18025290; 18974268; 30125549;
D000077209	Decitabine	DNMT3A protein affects the reaction [Decitabine results in increased expression of CDH1 mRNA]	16887905
D000077209	Decitabine	DNMT3B protein affects the reaction [Decitabine results in increased expression of CDH1 protein]	16887905
D000077209	Decitabine	Decitabine results in decreased expression of CDH1 mRNA	19222872; 27915011;
C107676	deguelin	deguelin affects the localization of CDH1 protein	22986522
C107676	deguelin	deguelin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]	22986522
C107676	deguelin	deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein]	22986522
C107676	deguelin	deguelin results in increased expression of CDH1 mRNA	22986522
C107676	deguelin	deguelin results in increased expression of CDH1 protein	22986522; 28509438;
C017185	delphinidin	delphinidin results in increased expression of CDH1 protein	29451351
D003703	Demecolcine	Demecolcine results in increased expression of CDH1 mRNA	23649840
D003840	Deoxycholic Acid	Deoxycholic Acid results in decreased glycosylation of and results in increased degradation of and results in decreased localization of CDH1 protein	22223758
D003840	Deoxycholic Acid	Erlotinib Hydrochloride promotes the reaction [Deoxycholic Acid results in decreased glycosylation of and results in increased degradation of CDH1 protein]	22223758
D003900	Desoxycorticosterone	Desoxycorticosterone results in decreased expression of CDH1 mRNA	17596522
D003900	Desoxycorticosterone	Desoxycorticosterone results in decreased expression of CDH1 protein	17596522
D003900	Desoxycorticosterone	Rotenone inhibits the reaction [Desoxycorticosterone results in decreased expression of CDH1 protein]	17596522
C040424	destruxin B	destruxin B results in increased expression of CDH1 protein	24434019
C040424	destruxin B	Sorafenib promotes the reaction [destruxin B results in increased expression of CDH1 protein]	24434019
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]	28300665; 28694203;
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]	28300665; 28694203;
D016264	Dextran Sulfate	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CDH1 mRNA	29950665
C028009	diallyl disulfide	diallyl disulfide results in decreased expression of CDH1 mRNA	20600798
C028009	diallyl disulfide	diallyl disulfide results in decreased expression of CDH1 protein	20600798
C042577	diallyl trisulfide	diallyl trisulfide results in increased expression of CDH1 protein	23412769
C042577	diallyl trisulfide	SOD2 protein inhibits the reaction [diallyl trisulfide results in increased expression of CDH1 protein]	23412769
C041517	dibenzo(a,l)pyrene	dibenzo(a,l)pyrene results in decreased expression of CDH1 mRNA	31255691
C041517	dibenzo(a,l)pyrene	dibenzo(a,l)pyrene results in increased expression of CDH1 mRNA	15735009
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CDH1 protein	22552774
D003993	Dibutyl Phthalate	Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]	30053495
D003993	Dibutyl Phthalate	Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]	30053495
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CDH1 mRNA	30053495
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CDH1 protein	30053495
D003993	Dibutyl Phthalate	Sirolimus promotes the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]	30053495
D003993	Dibutyl Phthalate	Sirolimus promotes the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]	30053495
D004008	Diclofenac	Diclofenac affects the expression of CDH1 mRNA	24752500
D004008	Diclofenac	Diclofenac results in increased expression of CDH1 protein	19628293
D004008	Diclofenac	Diclofenac results in decreased expression of CDH1 mRNA	19022234
C026398	dictamnine	[dictamnine co-treated with Oxygen deficiency] results in increased expression of CDH1 protein	30266538
C026398	dictamnine	dictamnine promotes the reaction [HIF1A protein affects the expression of CDH1 mRNA]	30266538
C026398	dictamnine	dictamnine promotes the reaction [HIF1A protein affects the expression of CDH1 protein]	30266538
C026398	dictamnine	dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH1 mRNA]	30266538
C026398	dictamnine	dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH1 protein]	30266538
C026398	dictamnine	dictamnine results in increased expression of CDH1 protein	30266538
D004041	Dietary Fats	Dietary Fats results in decreased expression of CDH1 mRNA	30120929
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of CDH1 protein	30944277
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of CDH1 mRNA	31163220
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of CDH1 mRNA	27058323
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CDH1 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CDH1 protein	25319454
D004052	Diethylnitrosamine	epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in decreased expression of CDH1 mRNA]	27058323
D004052	Diethylnitrosamine	theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of CDH1 mRNA]	27058323
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CDH1 protein	16439099; 25242112;
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of CDH1 mRNA	22193206
D015232	Dinoprostone	cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of CDH1 protein]	30208247
D015232	Dinoprostone	Dinoprostone results in decreased expression of CDH1 protein	30208247
C569454	diosbulbin B	diosbulbin B results in increased expression of CDH1 mRNA	30401638
D004147	Dioxins	Dioxins affects the expression of CDH1 mRNA	20463971
C516138	dorsomorphin	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal results in increased expression of CDH1 protein	25856345
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal affects the localization of CDH1 protein	23262642
C010945	embelin	embelin results in increased expression of CDH1 protein	24694877
C070609	EMD 53998	EMD 53998 analog results in decreased expression of CDH1 mRNA	24977338
D004642	Emodin	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]	27989784
D004642	Emodin	Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	27989784
D004642	Emodin	Emodin results in increased expression of CDH1 protein	27989784
D004642	Emodin	NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]	27989784
D004726	Endosulfan	Endosulfan inhibits the reaction [CDH1 protein binds to CTNNB1 protein]	22902829
D004726	Endosulfan	Endosulfan results in decreased expression of CDH1 mRNA	22677888; 22902829;
D004726	Endosulfan	Endosulfan results in decreased expression of CDH1 protein	22677888; 22902829; 28108160;
D004726	Endosulfan	Endosulfan results in decreased expression of CDH1 mRNA	29391264
C118739	entinostat	entinostat results in increased expression of CDH1 mRNA	26272509
C118739	entinostat	entinostat results in increased expression of CDH1 protein	29845424
C118739	entinostat	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C118739	entinostat	entinostat results in decreased expression of CDH1 mRNA	29845424
C118739	entinostat	entinostat results in decreased expression of CDH1 protein	29845424
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of CDH1 mRNA	20064776
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of CDH1 mRNA	25839702
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in decreased expression of CDH1 mRNA]	27058323
D000077545	Eplerenone	Eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]	17596522
D000077545	Eplerenone	Eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]	17596522
C015860	ergosta-4,6,8(14),22-tetraen-3-one	ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]	28578904
D000069347	Erlotinib Hydrochloride	Erlotinib Hydrochloride promotes the reaction [Deoxycholic Acid results in decreased glycosylation of and results in increased degradation of CDH1 protein]	22223758
D000069347	Erlotinib Hydrochloride	Erlotinib Hydrochloride results in decreased glycosylation of and results in increased degradation of CDH1 protein	22223758
D000069347	Erlotinib Hydrochloride	Erlotinib Hydrochloride results in decreased expression of CDH1 protein	24768708
D000069347	Erlotinib Hydrochloride	DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of CDH1 protein]	24768708
D000069347	Erlotinib Hydrochloride	Erlotinib Hydrochloride results in decreased expression of CDH1 mRNA	24768708
D004958	Estradiol	3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]	28844962
D004958	Estradiol	Estradiol results in decreased expression of CDH1 mRNA	20106945
D004958	Estradiol	Estradiol results in decreased expression of CDH1 protein	25690688; 26407941; 27539251; 28844962;
D004958	Estradiol	Fulvestrant inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]	25690688; 26407941; 27539251; 28844962;
D004958	Estradiol	Genistein inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]	26407941
D004958	Estradiol	plerixafor octahydrochloride inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]	28844962
D000431	Ethanol	Ethanol results in increased expression of CDH1 mRNA	28919490
D000431	Ethanol	[Ethanol co-treated with Folic Acid] results in increased expression of CDH1 mRNA	23378141
D000431	Ethanol	Ethanol results in decreased expression of CDH1 mRNA	23378141
D000431	Ethanol	[[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CDH1 mRNA	12072388
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CDH1 mRNA	17108234
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CDH1 mRNA	17557909
D000068338	Everolimus	Everolimus results in increased expression of CDH1 protein	28258630
D017313	Fenretinide	Fenretinide results in increased expression of CDH1 mRNA	28973697
D018120	Finasteride	Finasteride inhibits the reaction [Testosterone results in decreased expression of CDH1 mRNA]	27866977
C017875	fisetin	fisetin results in increased expression of CDH1 protein	30802432
D005411	Flame Retardants	Flame Retardants inhibits the reaction [CTNNB1 protein modified form binds to CDH1 protein]	28903489
D005411	Flame Retardants	Flame Retardants results in decreased expression of CDH1 protein	31241157
C018945	flubendazole	flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]	30075109
C108339	fludioxonil	fludioxonil results in decreased expression of CDH1 protein	27539251
C108339	fludioxonil	Fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDH1 protein]	27539251
C007738	fluoranthene	[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of CDH1 mRNA	17690111
D005472	Fluorouracil	CDH1 protein affects the susceptibility to Fluorouracil	15352031
D005472	Fluorouracil	Fluorouracil results in decreased expression of CDH1 protein	15352031; 26310874;
D005472	Fluorouracil	Resveratrol inhibits the reaction [Fluorouracil results in decreased expression of CDH1 protein]	26310874
D005492	Folic Acid	[Ethanol co-treated with Folic Acid] results in increased expression of CDH1 mRNA	23378141
D005492	Folic Acid	Folic Acid results in decreased expression of CDH1 protein	17868486
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDH1 protein	20548288
D005492	Folic Acid	[[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIR155 mRNA] which results in increased expression of CDH1 protein	20548288
D005557	Formaldehyde	Formaldehyde results in decreased expression of CDH1 protein	30236600
D005557	Formaldehyde	Formaldehyde results in increased expression of CDH1 mRNA	23649840; 28937961;
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in decreased expression of CDH1 protein]	27145024
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]	28284859
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [4-tert-octylphenol results in decreased expression of CDH1 protein]	27145024
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [[afimoxifene co-treated with EGF protein] results in increased expression of CDH1 protein]	19593637
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [afimoxifene results in increased expression of CDH1 protein]	19593637
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CDH1 protein]	28808208
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]	25690688; 26407941; 28844962;
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDH1 protein]	28808208
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bisphenol F results in increased expression of CDH1 protein]	28808208
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]	25690688; 26407941; 27539251; 28844962;
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [fludioxonil results in decreased expression of CDH1 protein]	27539251
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [nonylphenol results in decreased expression of CDH1 protein]	25690688; 26407941;
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]	28844962
C039281	furan	furan results in increased methylation of CDH1 gene	22079235
C025473	gamma-sitosterol	gamma-sitosterol results in increased expression of CDH1 mRNA	31112703
C025473	gamma-sitosterol	gamma-sitosterol results in increased expression of CDH1 protein	31112703
D005742	Gasoline	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D005742	Gasoline	[[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D005742	Gasoline	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which affects the expression of CDH1 mRNA	29432896
D005742	Gasoline	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D005742	Gasoline	[Gasoline results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
C001277	geldanamycin	geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]	17024233
C001277	geldanamycin	geldanamycin results in increased expression of CDH1 protein	17024233
C001277	geldanamycin	IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]	17024233
C001277	geldanamycin	IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein]	17024233
C056507	gemcitabine	gemcitabine results in increased expression of CDH1 mRNA	17039268
D019833	Genistein	Genistein inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]	26407941
D019833	Genistein	Genistein inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]	26407941
D019833	Genistein	Genistein inhibits the reaction [nonylphenol results in decreased expression of CDH1 protein]	26407941
D019833	Genistein	Genistein results in increased expression of CDH1	29899271
D019833	Genistein	Genistein results in decreased expression of CDH1 mRNA	21048042
D019833	Genistein	Genistein results in increased expression of CDH1 protein	17166883
D005839	Gentamicins	Gentamicins results in decreased expression of CDH1 mRNA	22061828
C007836	geraniol	geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein]	28428697
C097367	ginsenoside Rg3	ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	24793912
C055124	glaucocalyxin A	glaucocalyxin A inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]	31059706
C055124	glaucocalyxin A	glaucocalyxin A inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	31059706
C055124	glaucocalyxin A	glaucocalyxin A results in increased expression of CDH1 mRNA	31059706
C055124	glaucocalyxin A	glaucocalyxin A results in increased expression of CDH1 protein	31059706
D005947	Glucose	C646 compound inhibits the reaction [Glucose results in decreased expression of CDH1 protein]	26045780
D005947	Glucose	DKK1 protein inhibits the reaction [Glucose results in decreased expression of CDH1 mRNA]	29163160
D005947	Glucose	DKK1 protein inhibits the reaction [Glucose results in decreased expression of CDH1 protein]	29163160
D005947	Glucose	[Glucose co-treated with TGFB1 protein] results in decreased expression of CDH1 protein	21829520
D005947	Glucose	Glucose results in decreased expression of CDH1 mRNA	29163160
D005947	Glucose	Glucose results in decreased expression of CDH1 protein	21829520; 26045780; 29163160;
D005947	Glucose	MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in decreased expression of CDH1 protein]	21829520
D005947	Glucose	MAPK14 protein promotes the reaction [Glucose results in decreased expression of CDH1 protein]	21829520
C004312	glycidol	glycidol affects the methylation of CDH1 promoter	27884059
C508665	gold (III) porphyrin 1a	gold (III) porphyrin 1a results in increased expression of CDH1 mRNA	16206274
D056604	Grape Seed Extract	Grape Seed Extract inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]	28300665
D056604	Grape Seed Extract	Grape Seed Extract inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]	28300665
C000628859	GSK2193874	GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]	30517707
D006427	Hemin	[Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of CDH1 mRNA	29269057
D006533	Heptachlor	Heptachlor inhibits the reaction [CDH1 protein binds to CTNNB1 protein]	22902829
D006533	Heptachlor	Heptachlor results in decreased expression of CDH1 mRNA	22902829
D006533	Heptachlor	Heptachlor results in decreased expression of CDH1 protein	22902829
D006581	Hexachlorobenzene	[Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 protein	16679308
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]	18791180
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of CDH1 protein	22580338
D006861	Hydrogen Peroxide	[Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in decreased expression of CDH1 mRNA	24489904
C014290	hydroxyflutamide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [hydroxyflutamide results in increased phosphorylation of CDH1 protein]	28163245
C014290	hydroxyflutamide	hydroxyflutamide results in increased phosphorylation of CDH1 protein	28163245
C492448	ICG 001	ICG 001 inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]	28578904
D000068877	Imatinib Mesylate	Imatinib Mesylate inhibits the reaction [IL13 protein results in increased expression of CDH1 mRNA]	29730267
C082359	imidacloprid	imidacloprid results in increased expression of CDH1 mRNA	27792329
C082359	imidacloprid	imidacloprid results in increased expression of CDH1 protein	27792329
C540383	INCB018424	INCB018424 inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]	24820114
C545476	incobotulinumtoxinA	incobotulinumtoxinA results in increased expression of CDH1 mRNA	29522793
C016517	indole-3-carbinol	[Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of CDH1 mRNA	29269057
D007213	Indomethacin	Indomethacin results in increased expression of CDH1 mRNA	15963497
D007213	Indomethacin	Indomethacin results in increased expression of CDH1 protein	15963497
C040507	isobutyl alcohol	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which affects the expression of CDH1 mRNA	29432896
C040507	isobutyl alcohol	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
C005059	isoprene	isoprene results in decreased expression of CDH1 protein	30236600
D007559	Ivermectin	Ivermectin results in increased expression of CDH1	26078298
C057531	jasplakinolide	jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH1 protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH1 protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH1 protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH1 protein]	20388789
C057531	jasplakinolide	jasplakinolide results in decreased expression of CDH1 protein	25756282
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in increased expression of CDH1 mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in increased expression of CDH1 mRNA]	27392435
C544151	jinfukang	jinfukang results in increased expression of CDH1 mRNA	27392435
D048628	Ketolides	Ketolides analog results in increased expression of CDH1 mRNA	24967691
D019344	Lactic Acid	Lactic Acid results in decreased expression of CDH1 mRNA	30851411
D000077341	Lapatinib	[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein	26643609
D000077341	Lapatinib	Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein]	26643609
C037067	latrunculin A	latrunculin A results in decreased uptake of CDH1 protein modified form	20547569
C554430	LDN 193189	LDN 193189 results in increased expression of CDH1 protein	23243027
C032854	leupeptin	leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CDH1 protein]	19464575
C018584	linalool	linalool results in increased expression of CDH1 mRNA	26703569
C440499	lipopolysaccharide, Escherichia coli O111 B4	lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CDH1 mRNA	30753810
C440499	lipopolysaccharide, Escherichia coli O111 B4	lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CDH1 protein	30753810
C440499	lipopolysaccharide, Escherichia coli O111 B4	pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CDH1 mRNA]	30753810
C440499	lipopolysaccharide, Escherichia coli O111 B4	pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CDH1 protein]	30753810
C440499	lipopolysaccharide, Escherichia coli O111 B4	lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of CDH1 protein	25234611
C440499	lipopolysaccharide, Escherichia coli O111 B4	Resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of CDH1 protein]	25234611
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CDH1 mRNA	25069516
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CDH1 protein	25069516
D008070	Lipopolysaccharides	Resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of CDH1 mRNA]	25069516
D008070	Lipopolysaccharides	Resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of CDH1 protein]	25069516
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CDH1 mRNA	25613284
D008094	Lithium	Lithium results in increased expression of CDH1 protein	18296634
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDH1 protein]	22134133
D018021	Lithium Chloride	[Lithium Chloride results in decreased degradation of SNAI1 protein] which affects the expression of CDH1 protein	20348013
D008095	Lithocholic Acid	[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CDH1 mRNA	15489543
D008095	Lithocholic Acid	Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]]	31472180
D008095	Lithocholic Acid	Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]	31472180
D008095	Lithocholic Acid	VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CDH1 protein]]	31472180
C502354	lithocholic acid acetate	[lithocholic acid acetate binds to and results in increased activity of VDR protein] which results in increased expression of CDH1 mRNA	15489543
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]	28578904
C010480	lupeol	lupeol results in increased expression of CDH1 mRNA	31112703
C010480	lupeol	lupeol results in increased expression of CDH1 protein	31112703
D047311	Luteolin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased expression of CDH1 protein]	27474067
D047311	Luteolin	Luteolin results in increased expression of CDH1 protein	27474067
C530108	LY2109761	LY2109761 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]	25884904
C530108	LY2109761	LY2109761 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	25884904
C013592	mangiferin	mangiferin results in increased expression of CDH1 protein	23707762
D009637	Masoprocol	Masoprocol results in decreased methylation of CDH1 promoter	18418215
D009637	Masoprocol	Masoprocol results in increased expression of CDH1 mRNA	18418215
D009637	Masoprocol	Masoprocol results in increased expression of CDH1 protein	18418215
D008463	Mebendazole	Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]	30075109
D008555	Melitten	Melitten results in increased secretion of CDH1 protein	22613720
D008610	Menthol	Menthol results in increased expression of CDH1 mRNA	26760959
C042720	mercuric bromide	mercuric bromide results in increased expression of CDH1 mRNA	26272509
C042720	mercuric bromide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of CDH1 mRNA	20353558
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of CDH1 protein	20353558
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDH1 protein	20548288
D008715	Methionine	[[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MIR155 mRNA] which results in increased expression of CDH1 protein	20548288
D008727	Methotrexate	CDH1 mRNA results in increased susceptibility to Methotrexate	18694510
D008727	Methotrexate	Methotrexate results in increased expression of CDH1 protein	21114963
C013598	methoxyacetic acid	methoxyacetic acid results in increased expression of CDH1 mRNA	20864626
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of CDH1 protein	16619036
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CDH1 mRNA	23458150
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CDH1 mRNA	23179753; 27188386;
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CDH1 mRNA	23179753; 26272509;
C004925	methylmercuric chloride	[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of CDH1 mRNA	21613230
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CDH1 mRNA	20864626
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CDH1 protein	28526320
D008769	Methylnitronitrosoguanidine	geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein]	28428697
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in decreased expression of CDH1 protein	28428697
D008770	Methylnitrosourea	Methylnitrosourea results in decreased expression of CDH1 mRNA	27221058
D008770	Methylnitrosourea	[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA	25164625
D008770	Methylnitrosourea	[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein	25164625
D008770	Methylnitrosourea	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA]	25164625
D008770	Methylnitrosourea	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein]	25164625
D015741	Metribolone	Metribolone affects the localization of CDH1 protein	17440980
D015735	Mifepristone	Mifepristone results in increased expression of CDH1 mRNA	17584828
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of CDH1 protein]	17478549
C548887	MK 2206	[MK 2206 co-treated with U 0126] results in increased expression of CDH1 mRNA	30723155
C548887	MK 2206	MK 2206 results in increased expression of CDH1 mRNA	30723155
C060893	MK-886	[MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CDH1 protein]	23978332
C060893	MK-886	MK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]	20061081
C070571	ML 7	ML 7 affects the localization of CDH1 protein	16030252
C070571	ML 7	ML 7 results in decreased activity of CDH1 protein	16030252
C408362	momordin I (Oleanolic Acid)	momordin I (Oleanolic Acid) results in increased expression of CDH1 protein	30654085
C408362	momordin I (Oleanolic Acid)	VEGFA protein inhibits the reaction [momordin I (Oleanolic Acid) results in increased expression of CDH1 protein]	30654085
C028577	monobutyl phthalate	monobutyl phthalate results in increased expression of CDH1 mRNA	20864626
C020300	monomethylarsonic acid	monomethylarsonic acid results in increased expression of CDH1 mRNA	17481689
C406082	monomethylarsonous acid	monomethylarsonous acid affects the expression of CDH1 mRNA	20886546
C057451	morusin	morusin results in increased expression of CDH1 protein	25476160
C500085	muraglitazar	muraglitazar results in decreased expression of CDH1 mRNA	21515302
C001020	N(6),N(6)-dimethyladenine	N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]	15618353
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of CDH1 mRNA	25620056
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of CDH1 mRNA	25620056
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased secretion of CDH1 protein	25598225
D009355	Neomycin	Neomycin results in decreased expression of CDH1 protein	15953529
C115174	netoglitazone	netoglitazone results in increased expression of CDH1 protein	14977855
D009532	Nickel	Nickel results in increased expression of CDH1 mRNA	24084258
C022838	nickel chloride	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]	22648416
C022838	nickel chloride	Acetylcysteine inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]	22648416
C022838	nickel chloride	Acetylcysteine inhibits the reaction [nickel chloride results in increased methylation of CDH1 promoter]	22648416
C022838	nickel chloride	Allopurinol inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]	22648416
C022838	nickel chloride	Decitabine inhibits the reaction [nickel chloride results in decreased expression of CDH1 mRNA]	22648416
C022838	nickel chloride	HIF1A mutant form inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]	22648416
C022838	nickel chloride	nickel chloride promotes the reaction [HIF1A protein binds to CDH1 promoter]	22648416
C022838	nickel chloride	nickel chloride promotes the reaction [SNAI1 protein binds to CDH1 promoter]	22648416
C022838	nickel chloride	nickel chloride promotes the reaction [SNAI2 protein binds to CDH1 promoter]	22648416
C022838	nickel chloride	nickel chloride results in decreased expression of CDH1 mRNA	22648416
C022838	nickel chloride	nickel chloride results in decreased expression of CDH1 protein	22648416
C022838	nickel chloride	nickel chloride results in increased methylation of CDH1 promoter	22648416
C029938	nickel sulfate	nickel sulfate results in decreased expression of CDH1 mRNA	16780908
C029938	nickel sulfate	nickel sulfate results in decreased expression of CDH1 protein	15588916; 22648416;
C029938	nickel sulfate	pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CDH1 protein]	15588916
D009534	Niclosamide	Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein]	26643609
D009534	Niclosamide	Niclosamide results in increased expression of CDH1 protein	25174399
D009534	Niclosamide	WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]	25174399
D009538	Nicotine	MK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]	20061081
D009538	Nicotine	Nicotine results in decreased expression of CDH1 mRNA	20061081; 23219715;
D009538	Nicotine	Nicotine results in decreased expression of CDH1 protein	18844224
D009538	Nicotine	U 0126 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]	20061081
D009569	Nitric Oxide	Nitric Oxide results in decreased expression of CDH1 mRNA	20179380
C047330	N-methylisoindigotin	N-methylisoindigotin results in increased expression of CDH1 mRNA	26887594
C000623013	NMS-873	NMS-873 results in decreased expression of CDH1 protein	29693262
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	[N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester co-treated with 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one] inhibits the reaction [polyhexamethyleneguanidine results in decreased expression of CDH1 protein]	31348943
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased secretion of CDH1 protein]	18791180
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium results in increased cleavage of CDH1 protein]	18791180
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein	16844947
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein]	16844947
C025256	nonylphenol	Fulvestrant inhibits the reaction [nonylphenol results in decreased expression of CDH1 protein]	25690688; 26407941;
C025256	nonylphenol	Genistein inhibits the reaction [nonylphenol results in decreased expression of CDH1 protein]	26407941
C025256	nonylphenol	nonylphenol results in decreased expression of CDH1 protein	25690688
C520337	NSC 74859	NSC 74859 affects the expression of CDH1 protein	25476160
C025589	ochratoxin A	[Citrinin co-treated with ochratoxin A] results in decreased expression of CDH1 mRNA	29673704
C025589	ochratoxin A	[ochratoxin A co-treated with Citrinin] results in decreased expression of CDH1 protein	29673704
C025589	ochratoxin A	ochratoxin A results in decreased expression of CDH1 mRNA	29673704
C025589	ochratoxin A	ochratoxin A results in decreased expression of CDH1 mRNA	16857307
D019319	Okadaic Acid	Okadaic Acid promotes the reaction [CTNNB1 protein binds to CDH1 protein]	31115591
C011959	oridonin	oridonin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 mRNA]	30243739
C011959	oridonin	oridonin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]	30243739
C011959	oridonin	oridonin results in increased expression of CDH1 mRNA	30243739
C011959	oridonin	oridonin results in increased expression of CDH1 protein	30243739
C485800	osajin	osajin results in increased expression of CDH1 mRNA	20706672
D010042	Ouabain	Ouabain results in decreased expression of CDH1 protein	28795476
D010042	Ouabain	Ouabain results in increased expression of CDH1 mRNA	28795476
D000077150	Oxaliplatin	[Oxaliplatin co-treated with Topotecan] results in decreased expression of CDH1 mRNA	25729387
D010100	Oxygen	DICER1 protein inhibits the reaction [Oxygen deficiency results in decreased expression of CDH1 mRNA]	25351418
D010100	Oxygen	[dictamnine co-treated with Oxygen deficiency] results in increased expression of CDH1 protein	30266538
D010100	Oxygen	HIF1A protein promotes the reaction [Oxygen deficiency results in decreased expression of CDH1 mRNA]	22340517
D010100	Oxygen	Oxygen deficiency results in decreased expression of CDH1 mRNA	22340517; 25351418;
D010100	Oxygen	Oxygen deficiency results in decreased expression of CDH1 protein	22340517; 25351418;
D010100	Oxygen	[Butylated Hydroxytoluene co-treated with Oxygen] results in decreased expression of CDH1 protein	16272459
D010100	Oxygen	Oxygen deficiency results in increased expression of CDH1 mRNA	24205000
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of CDH1 mRNA	21632981
D010126	Ozone	[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of CDH1 mRNA	23246600
C102487	pachymic acid	pachymic acid analog inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]	28578904
C500026	palbociclib	CDH1 protein affects the reaction [palbociclib results in decreased expression of FOXM1 protein]	22094256
C500026	palbociclib	palbociclib affects the localization of CDH1 protein	22869556
D000077767	Panobinostat	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
D000077767	Panobinostat	Panobinostat results in increased expression of CDH1 mRNA	26272509
C016030	pantogab	pantogab results in decreased expression of CDH1 mRNA	17379144
D010269	Paraquat	Anthocyanins inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]	30403199
D010269	Paraquat	NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]]	28624451
D010269	Paraquat	Paraquat results in decreased expression of CDH1 mRNA	28624451; 30403199;
D010269	Paraquat	Paraquat results in decreased expression of CDH1 protein	25873302; 28624451; 30403199;
D010269	Paraquat	Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 mRNA]	28624451
D010269	Paraquat	Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]	28624451
D010269	Paraquat	sulforafan inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]	28624451
D052638	Particulate Matter	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D052638	Particulate Matter	[[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D052638	Particulate Matter	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which affects the expression of CDH1 mRNA	29432896
D052638	Particulate Matter	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D052638	Particulate Matter	[Gasoline results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D052638	Particulate Matter	Particulate Matter affects the localization of CDH1 protein	29987410
D052638	Particulate Matter	Particulate Matter results in decreased expression of CDH1 mRNA	22178795; 22369193; 28846189; 30716388; 31520698;
D052638	Particulate Matter	Particulate Matter results in decreased expression of CDH1 protein	28846189
D052638	Particulate Matter	[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CDH1 mRNA	30010986
D052638	Particulate Matter	[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CDH1 protein	30010986
D052638	Particulate Matter	Particulate Matter results in decreased expression of CDH1 mRNA	30391304
D052638	Particulate Matter	Particulate Matter results in decreased expression of CDH1 protein	30391304
D052638	Particulate Matter	Poly G inhibits the reaction [Particulate Matter results in decreased expression of CDH1 mRNA]	30391304
D052638	Particulate Matter	Poly G inhibits the reaction [Particulate Matter results in decreased expression of CDH1 protein]	30391304
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of CDH1 mRNA	26272509
C066957	pelargonidin	pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CDH1 mRNA]	30753810
C066957	pelargonidin	pelargonidin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CDH1 protein]	30753810
C076994	perfluorooctane sulfonic acid	[perfluorooctane sulfonic acid co-treated with Tretinoin] results in decreased expression of CDH1 mRNA	23948355
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CDH1 mRNA	23948355
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CDH1 protein	28973641
C076994	perfluorooctane sulfonic acid	Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CDH1 protein]	28973641
C023036	perfluorooctanoic acid	[MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CDH1 protein]	23978332
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CDH1 protein	23978332
C023036	perfluorooctanoic acid	[perfluorooctanoic acid co-treated with Tretinoin] results in decreased expression of CDH1 mRNA	23948355
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CDH1 mRNA	23948355
C023036	perfluorooctanoic acid	WNT3A protein inhibits the reaction [perfluorooctanoic acid results in decreased expression of CDH1 protein]	23978332
C076715	pervanadate	pervanadate inhibits the reaction [Arsenic Trioxide results in increased expression of CDH1 protein]	29409467
D010575	Pesticides	Pesticides results in increased methylation of CDH1 promoter	29250973
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CDH1 mRNA]	19482888
D010634	Phenobarbital	NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of CDH1 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of CDH1 mRNA	19482888; 23091169;
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of CDH1 mRNA	26272509
D064209	Phytochemicals	Phytochemicals analog results in increased expression of CDH1 protein	25980589
D010862	Pilocarpine	Pilocarpine results in decreased expression of CDH1 protein	12387456
D010862	Pilocarpine	Pilocarpine results in increased expression of CDH1 protein	12387456
C006253	pirinixic acid	pirinixic acid results in decreased expression of CDH1 mRNA	18445702; 23811191;
D010936	Plant Extracts	HOTAIR mutant form inhibits the reaction [Plant Extracts analog results in decreased expression of CDH1 protein]	25447409
D010936	Plant Extracts	Plant Extracts analog results in decreased expression of CDH1 protein	25447409
D010936	Plant Extracts	Plant Extracts inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	28258635
D010936	Plant Extracts	Plant Extracts results in increased expression of CDH1 mRNA	31112703
D010936	Plant Extracts	Plant Extracts results in increased expression of CDH1 protein	28371048; 31112703;
D010936	Plant Extracts	Plant Extracts affects the localization of CDH1 protein	23262642
C088327	plerixafor octahydrochloride	plerixafor octahydrochloride inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]	28844962
C088327	plerixafor octahydrochloride	plerixafor octahydrochloride inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]	28844962
C088327	plerixafor octahydrochloride	plerixafor octahydrochloride inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]	28844962
D008926	Plicamycin	Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]]	19593637
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in increased methylation of CDH1 promoter	29250973
D011084	Polycyclic Aromatic Hydrocarbons	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D011084	Polycyclic Aromatic Hydrocarbons	[[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D011084	Polycyclic Aromatic Hydrocarbons	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which affects the expression of CDH1 mRNA	29432896
D011084	Polycyclic Aromatic Hydrocarbons	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D011084	Polycyclic Aromatic Hydrocarbons	[Gasoline results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CDH1 mRNA	29432896
D011092	Polyethylene Glycols	Polyethylene Glycols results in increased expression of CDH1 mRNA	22558349
D011068	Poly G	Poly G inhibits the reaction [Particulate Matter results in decreased expression of CDH1 mRNA]	30391304
D011068	Poly G	Poly G inhibits the reaction [Particulate Matter results in decreased expression of CDH1 protein]	30391304
D011068	Poly G	Poly G inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 mRNA]	30391304; 31028789;
D011068	Poly G	Poly G inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]	30391304; 31028789;
C060540	polyhexamethyleneguanidine	AKT1 protein affects the reaction [polyhexamethyleneguanidine results in decreased expression of CDH1 mRNA]	31348943
C060540	polyhexamethyleneguanidine	[N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester co-treated with 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one] inhibits the reaction [polyhexamethyleneguanidine results in decreased expression of CDH1 protein]	31348943
C060540	polyhexamethyleneguanidine	NOTCH1 protein affects the reaction [polyhexamethyleneguanidine results in decreased expression of CDH1 mRNA]	31348943
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine affects the expression of CDH1 mRNA	29337256
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine affects the expression of CDH1 protein	25716161
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in decreased expression of CDH1 mRNA	31348943
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in decreased expression of CDH1 protein	29337256; 31348943;
C060540	polyhexamethyleneguanidine	ZEB2 protein affects the reaction [polyhexamethyleneguanidine results in decreased expression of CDH1 protein]	31348943
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in decreased expression of CDH1 protein	31348943
C474837	pomiferin	pomiferin results in increased expression of CDH1 mRNA	20706672
C479580	procyanidin B2	procyanidin B2 results in increased expression of CDH1 mRNA	25839702
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of CDH1 protein]	17478549
D011374	Progesterone	Progesterone results in decreased expression of CDH1 protein	17478549
C066229	prolinedithiocarbamate	prolinedithiocarbamate affects the expression of CDH1 protein	25476160
C066229	prolinedithiocarbamate	prolinedithiocarbamate results in increased expression of CDH1 protein	27279714
C066229	prolinedithiocarbamate	Quercetin promotes the reaction [prolinedithiocarbamate results in increased expression of CDH1 protein]	27279714
D011429	Propolis	Propolis results in increased expression of CDH1 mRNA	20706672
C005581	protocatechualdehyde	protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	25582705
C107773	pterostilbene	pterostilbene results in increased expression of CDH1 protein	23921149
C107773	pterostilbene	pterostilbene inhibits the reaction [Azoxymethane results in decreased expression of CDH1 protein]	20681671
C033607	puerarin	puerarin results in increased expression of CDH1 mRNA	20706672
C432165	pyrazolanthrone	pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CDH1 protein]	15588916
C432165	pyrazolanthrone	pyrazolanthrone results in decreased expression of CDH1 protein	15588916
C014175	pyrazolo(3,4-d)pyrimidine	pyrazolo(3,4-d)pyrimidine analog affects the expression of CDH1 mRNA	21152443
C587274	Qing Ye Dan	Qing Ye Dan inhibits the reaction [Testosterone results in decreased expression of CDH1 mRNA]	27866977
D011794	Quercetin	Quercetin promotes the reaction [prolinedithiocarbamate results in increased expression of CDH1 protein]	27279714
D011794	Quercetin	Quercetin promotes the reaction [TLR4 protein affects the expression of CDH1 protein]	27279714
D011794	Quercetin	Quercetin results in decreased expression of CDH1 mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of CDH1 protein	27279714
D011794	Quercetin	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA]	25164625
D011794	Quercetin	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein]	25164625
D011794	Quercetin	Quercetin results in decreased expression of CDH1 mRNA	28431985
D011794	Quercetin	Quercetin results in decreased expression of CDH1 protein	28431985
C012526	quercitrin	quercitrin results in decreased expression of CDH1 mRNA	25193878
C502851	quinocetone	quinocetone results in increased expression of CDH1 mRNA	27046791
D017382	Reactive Oxygen Species	[Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in decreased expression of CDH1 mRNA	24489904
D000077185	Resveratrol	Resveratrol inhibits the reaction [Fluorouracil results in decreased expression of CDH1 protein]	26310874
D000077185	Resveratrol	Resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of CDH1 mRNA]	25069516
D000077185	Resveratrol	Resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of CDH1 protein]	25069516
D000077185	Resveratrol	Resveratrol inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]	23146760; 23992306; 25884904;
D000077185	Resveratrol	Resveratrol inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	23146760; 23992306; 25884904;
D000077185	Resveratrol	Resveratrol results in decreased expression of CDH1 protein	18089832
D000077185	Resveratrol	Resveratrol results in increased expression of CDH1 mRNA	20706672; 22692956; 23992306; 25896424;
D000077185	Resveratrol	Resveratrol results in increased expression of CDH1 protein	20637737; 22692956; 23921149; 23992306; 25896424; 26310874;
D000077185	Resveratrol	Resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of CDH1 protein]	25234611
D000077185	Resveratrol	Resveratrol inhibits the reaction [EGF protein results in decreased expression of CDH1 mRNA]	21794976
C086492	Ro 24-5531	Ro 24-5531 inhibits the reaction [Azoxymethane results in increased expression of CDH1 protein]	12496057
D000077154	Rosiglitazone	Rosiglitazone results in increased expression of CDH1 mRNA	22684020
D000077154	Rosiglitazone	Rosiglitazone results in increased expression of CDH1 protein	16806087
D000077154	Rosiglitazone	Rosiglitazone results in decreased expression of CDH1 mRNA	21515302
D012402	Rotenone	Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]	17596522
D012402	Rotenone	Rotenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]	17596522
D012402	Rotenone	Rotenone inhibits the reaction [Desoxycorticosterone results in decreased expression of CDH1 protein]	17596522
C101044	RTKI cpd	RTKI cpd results in increased expression of CDH1 protein	25856345
C010327	salinomycin	salinomycin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	26896736; 30273566;
C065299	S-allylcysteine	S-allylcysteine results in increased expression of CDH1 protein	17155983
C496827	salubrinal	salubrinal inhibits the reaction [Cyclosporine results in decreased expression of CDH1 protein]	22155090
C093642	SB 203580	SB 203580 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	28694203
C417521	SB 216763	SB 216763 inhibits the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]	26685284
C417521	SB 216763	SB 216763 results in decreased expression of CDH1 protein	23921149
C414354	selamectin	selamectin results in increased expression of CDH1	26078298
D012715	Sesame Oil	Sesame Oil results in decreased expression of CDH1 mRNA	29191790
D012822	Silicon Dioxide	MIR200C mRNA inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]	29113749
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CDH1 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of CDH1 protein	29113749
D012822	Silicon Dioxide	[Silicon Dioxide results in increased secretion of TGFB1 protein] which results in decreased expression of CDH1 protein	29113749
D012822	Silicon Dioxide	Poly G inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 mRNA]	30391304; 31028789;
D012822	Silicon Dioxide	Poly G inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]	30391304; 31028789;
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of CDH1 mRNA	30391304; 31028789;
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of CDH1 protein	30391304; 31028789;
D012834	Silver	Silver results in decreased expression of CDH1 mRNA	27131904
D018030	Silver Compounds	Silver Compounds results in decreased expression of CDH1 mRNA	29703973
D018030	Silver Compounds	Silver Compounds results in decreased expression of CDH1 protein	29703973
D020123	Sirolimus	Sirolimus inhibits the reaction [sodium arsenite results in decreased expression of CDH1 protein]	28888487
D020123	Sirolimus	Sirolimus results in increased expression of CDH1 protein	28888487
D020123	Sirolimus	NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]]	28624451
D020123	Sirolimus	Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 mRNA]	28624451
D020123	Sirolimus	Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]	28624451
D020123	Sirolimus	Sirolimus promotes the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]	30053495
D020123	Sirolimus	Sirolimus promotes the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]	30053495
D012906	Smoke	Decitabine inhibits the reaction [Smoke results in decreased expression of CDH1 mRNA]	21095227
D012906	Smoke	HOTAIR mutant form inhibits the reaction [Smoke analog results in decreased expression of CDH1 protein]	25447409
D012906	Smoke	Smoke analog affects the expression of CDH1	23174910
D012906	Smoke	Smoke analog affects the methylation of CDH1 promoter	23174910
D012906	Smoke	Smoke analog results in decreased expression of CDH1 protein	25447409
D012906	Smoke	Smoke results in decreased expression of CDH1 mRNA	21095227
C009277	sodium arsenate	sodium arsenate results in increased expression of CDH1 mRNA	30953684
C017947	sodium arsenite	Decitabine inhibits the reaction [sodium arsenite results in decreased expression of CDH1 mRNA]	30191986
C017947	sodium arsenite	MIR191 mRNA promotes the reaction [sodium arsenite results in decreased expression of CDH1 protein]	29277653
C017947	sodium arsenite	Sirolimus inhibits the reaction [sodium arsenite results in decreased expression of CDH1 protein]	28888487
C017947	sodium arsenite	SNAI1 protein affects the reaction [sodium arsenite results in decreased expression of CDH1 protein]	28888487
C017947	sodium arsenite	sodium arsenite affects the expression of CDH1 mRNA	27224422
C017947	sodium arsenite	sodium arsenite affects the expression of CDH1 protein	27224422
C017947	sodium arsenite	sodium arsenite results in decreased expression of CDH1 mRNA	12634122; 22662215; 24068038; 28888487; 29301061; 30191986;
C017947	sodium arsenite	sodium arsenite results in decreased expression of CDH1 protein	21292642; 22648416; 22662215; 24068038; 25879800; 28888487; 29277653; 30309986;
C017947	sodium arsenite	sodium arsenite results in increased expression of CDH1	25804888
C017947	sodium arsenite	sodium arsenite results in increased expression of CDH1 mRNA	31120745
C017947	sodium arsenite	sodium arsenite results in increased expression of CDH1 protein alternative form	30137596
C017947	sodium arsenite	SQSTM1 protein affects the reaction [sodium arsenite results in decreased expression of CDH1 protein]	28888487
C017947	sodium arsenite	sodium arsenite affects the expression of CDH1 mRNA	16507464
D053260	Soot	Soot results in decreased expression of CDH1 mRNA	26551751
C120642	sophoricoside	sophoricoside results in decreased expression of CDH1	24877640
D000077157	Sorafenib	Sorafenib inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	21360571
D000077157	Sorafenib	Sorafenib promotes the reaction [destruxin B results in increased expression of CDH1 protein]	24434019
D000077157	Sorafenib	Sorafenib results in increased expression of CDH1 protein	24434019
C026411	sorbinil	sorbinil inhibits the reaction [AKR1B1 protein results in decreased expression of CDH1 mRNA]	28137510
D012460	Sulfasalazine	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]	19015640
D012460	Sulfasalazine	[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA	19015640
C016766	sulforafan	sulforafan results in increased expression of CDH1	29899271
C016766	sulforafan	sulforafan inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]	28624451
C452601	sulindac derivative IND 12	sulindac derivative IND 12 promotes the reaction [CDH1 protein binds to CTNNB1 protein]	11912145
C452601	sulindac derivative IND 12	sulindac derivative IND 12 results in increased expression of CDH1 protein	11912145
C025462	sulindac sulfide	sulindac sulfide results in increased expression of and results in increased activity of CDH1 protein	12391285
C013270	swertiamarin	swertiamarin inhibits the reaction [Testosterone results in decreased expression of CDH1 mRNA]	27866977
D016559	Tacrolimus	Tacrolimus results in decreased expression of CDH1 protein	22416070
D013629	Tamoxifen	Tamoxifen results in increased expression of CDH1 mRNA	26908177
D013629	Tamoxifen	3,4',5-trimethoxystilbene promotes the reaction [Tamoxifen results in increased expression of CDH1 protein]	23921149
D013629	Tamoxifen	Tamoxifen promotes the reaction [3,4',5-trimethoxystilbene results in increased expression of CDH1 protein]	23921149
D013629	Tamoxifen	Tamoxifen results in increased expression of CDH1 protein	23921149
D013629	Tamoxifen	Tamoxifen affects the expression of CDH1 mRNA	20937368
C501413	tesaglitazar	tesaglitazar results in decreased expression of CDH1 mRNA	21515302
D013739	Testosterone	Finasteride inhibits the reaction [Testosterone results in decreased expression of CDH1 mRNA]	27866977
D013739	Testosterone	[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA	25164625
D013739	Testosterone	[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein	25164625
D013739	Testosterone	Qing Ye Dan inhibits the reaction [Testosterone results in decreased expression of CDH1 mRNA]	27866977
D013739	Testosterone	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA]	25164625
D013739	Testosterone	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein]	25164625
D013739	Testosterone	swertiamarin inhibits the reaction [Testosterone results in decreased expression of CDH1 mRNA]	27866977
D013739	Testosterone	Testosterone results in decreased expression of CDH1 mRNA	27866977
D013749	Tetrachlorodibenzodioxin	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDH1 mRNA]	29704546
D013749	Tetrachlorodibenzodioxin	Lithium Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDH1 protein]	22134133
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CDH1 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CDH1 mRNA	12377990; 20106945; 21632981; 22902829; 26238291; 29704546;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CDH1 protein	16619036; 22134133; 22902829; 26971374;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CDH1 mRNA	12377990
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CDH1 mRNA	24154488; 26290441;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CDH1 protein	19490989; 24154488;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CDH1 mRNA	27562557
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of CDH1 protein	21602191
D013755	Tetradecanoylphorbol Acetate	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]	25656647
D013755	Tetradecanoylphorbol Acetate	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]	25656647
D013755	Tetradecanoylphorbol Acetate	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]	25656647
D013755	Tetradecanoylphorbol Acetate	antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]	25656647
D013755	Tetradecanoylphorbol Acetate	Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]	25656647
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein	25656647
C034269	tetraethylenepentamine	tetraethylenepentamine inhibits the reaction [cobaltous chloride results in decreased expression of CDH1 protein]	26174737
C034269	tetraethylenepentamine	tetraethylenepentamine results in increased expression of CDH1 protein	26174737
C050950	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]	18791180
C009438	tetrandrine	tetrandrine results in decreased expression of CDH1 protein	30549224
C056068	theaflavin	theaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of CDH1 mRNA]	27058323
D013853	Thioacetamide	Thioacetamide results in increased expression of CDH1 mRNA	23411599
C009495	titanium dioxide	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CDH1 mRNA	29950665
C009495	titanium dioxide	titanium dioxide results in increased expression of CDH1 mRNA	23557971
D014028	Tobacco Smoke Pollution	andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]	31128153
D014028	Tobacco Smoke Pollution	IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]]	31128153
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CDH1 mRNA	29505817
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CDH1 protein	30291989
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA	27404394; 27865774; 28065790;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CDH1 protein	27087172; 27404394; 29505817; 30610935; 31128153;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased methylation of CDH1 promoter	25214829
D014028	Tobacco Smoke Pollution	Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]	26191140
D014028	Tobacco Smoke Pollution	Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]	26191140
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA	26191140
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CDH1 protein	26191140; 31128153;
C009500	tolfenamic acid	[tolfenamic acid co-treated with TGFB1 protein] results in increased expression of CDH1 protein	31381904
C009500	tolfenamic acid	tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]	31381904
C009500	tolfenamic acid	tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	31381904
D014051	Toluene 2,4-Diisocyanate	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]	30517707
D014051	Toluene 2,4-Diisocyanate	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]	26089345
D014051	Toluene 2,4-Diisocyanate	GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]	30517707
D014051	Toluene 2,4-Diisocyanate	Toluene 2,4-Diisocyanate affects the localization of CDH1 protein	30517707
D014051	Toluene 2,4-Diisocyanate	Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CDH1 protein	26089345
D019772	Topotecan	CDH1 protein affects the susceptibility to Topotecan	16217747
D019772	Topotecan	[Oxaliplatin co-treated with Topotecan] results in decreased expression of CDH1 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of CDH1 mRNA	25729387
D014118	Toxins, Biological	Toxins, Biological affects the expression of CDH1 mRNA	19682533
D014212	Tretinoin	Arsenic Trioxide promotes the reaction [Tretinoin results in increased expression of CDH1 mRNA]	30093655
D014212	Tretinoin	Tretinoin affects the expression of CDH1 mRNA	17034753
D014212	Tretinoin	Tretinoin promotes the reaction [Arsenic Trioxide results in increased expression of CDH1 mRNA]	30093655
D014212	Tretinoin	Tretinoin results in decreased expression of CDH1 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of CDH1 mRNA	21934132; 30093655;
D014212	Tretinoin	Tretinoin results in increased expression of CDH1 protein	23527294
D014212	Tretinoin	[bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of CDH1 mRNA	30951980
D014212	Tretinoin	[bisphenol F co-treated with Tretinoin] results in decreased expression of CDH1 mRNA	30951980
D014212	Tretinoin	[perfluorooctane sulfonic acid co-treated with Tretinoin] results in decreased expression of CDH1 mRNA	23948355
D014212	Tretinoin	[perfluorooctanoic acid co-treated with Tretinoin] results in decreased expression of CDH1 mRNA	23948355
D014212	Tretinoin	Tretinoin affects the expression of CDH1 mRNA	16211290
D014212	Tretinoin	Tretinoin results in increased expression of CDH1 mRNA	16236135; 16788091;
D014212	Tretinoin	Tretinoin results in increased expression of CDH1 mRNA	24977338
C012589	trichostatin A	[[Decitabine co-treated with trichostatin A] affects the acetylation of H3-4 protein] which affects the expression of CDH1 mRNA	18584348
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
C012589	trichostatin A	[trichostatin A affects the acetylation of H3-4 protein] which affects the expression of CDH1 mRNA	18584348
C012589	trichostatin A	trichostatin A inhibits the reaction [chromium hexavalent ion results in decreased expression of CDH1 protein]	23518002
C012589	trichostatin A	trichostatin A results in increased expression of CDH1 mRNA	24935251; 26272509;
C012589	trichostatin A	trichostatin A results in increased expression of CDH1 protein	18025290
D014260	Triclosan	3,3'-diindolylmethane inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]	28844962
D014260	Triclosan	Fulvestrant inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]	28844962
D014260	Triclosan	plerixafor octahydrochloride inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]	28844962
D014260	Triclosan	Triclosan results in decreased expression of CDH1 protein	28844962
D014260	Triclosan	Triclosan results in increased expression of CDH1 mRNA	30510588
C052920	trimethylarsine oxide	trimethylarsine oxide results in increased expression of CDH1 mRNA	17481689
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of CDH1 mRNA	29024780
D000077288	Troglitazone	Troglitazone results in increased expression of CDH1 mRNA	19285010; 22684020;
D000077288	Troglitazone	Troglitazone results in increased expression of CDH1 protein	19285010
D000077288	Troglitazone	Troglitazone results in decreased expression of CDH1 mRNA	19022234; 21515302;
D014415	Tunicamycin	Tunicamycin results in increased expression of CDH1 mRNA	17127020
C113580	U 0126	U 0126 inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDH1 protein]	22307971
C113580	U 0126	U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]	17596522
C113580	U 0126	U 0126 inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]	17596522
C113580	U 0126	U 0126 inhibits the reaction [FGF16 protein results in decreased expression of CDH1 mRNA]	24253043
C113580	U 0126	U 0126 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]	20061081
C113580	U 0126	U 0126 results in increased expression of CDH1 mRNA	19285010
C113580	U 0126	U 0126 results in increased expression of CDH1 protein	19285010; 22307971;
C113580	U 0126	[MK 2206 co-treated with U 0126] results in increased expression of CDH1 mRNA	30723155
C113580	U 0126	U 0126 results in increased expression of CDH1 mRNA	30723155
C022884	undecane	undecane results in decreased expression of CDH1 protein	17337753
D014520	Urethane	Urethane results in decreased expression of CDH1 mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of CDH1 protein]	12496057
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of CDH1 mRNA	15885361
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of CDH1 mRNA	23179753; 23527032; 24383497; 24935251; 26272509; 28001369;
D014635	Valproic Acid	Valproic Acid results in increased expression of CDH1 protein	19628293; 29845424;
D014635	Valproic Acid	Valproic Acid affects the expression of CDH1 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in decreased expression of CDH1 mRNA	31445079
D014635	Valproic Acid	Valproic Acid results in decreased expression of CDH1 protein	29845424
D014635	Valproic Acid	Valproic Acid results in increased expression of CDH1 mRNA	30578912
D014635	Valproic Acid	Valproic Acid results in increased expression of CDH1 protein	19628293
D014635	Valproic Acid	Valproic Acid results in increased expression of CDH1 mRNA	29427782
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of CDH1 mRNA	22369193
D001335	Vehicle Emissions	[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CDH1 mRNA	30010986
D001335	Vehicle Emissions	[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CDH1 protein	30010986
C025643	vinclozolin	vinclozolin affects the expression of CDH1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of CDH1 mRNA	20566332
D014750	Vincristine	Vincristine results in increased expression of CDH1 mRNA	23649840
C017963	vinyl carbamate	vinyl carbamate results in decreased expression of CDH1 mRNA	17849452
D014801	Vitamin A	Vitamin A affects the expression of CDH1 mRNA	17034753
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of CDH1 protein	31238027
D000077337	Vorinostat	Decitabine promotes the reaction [Vorinostat results in increased expression of CDH1 mRNA]	17417771
D000077337	Vorinostat	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH1 mRNA	27188386
D000077337	Vorinostat	Vorinostat results in increased expression of CDH1 mRNA	17417771
D014859	Warfarin	Warfarin results in increased expression of CDH1 protein	26206560
D014874	Water Pollutants, Chemical	[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of CDH1 mRNA	23246600
C000588914	WJ1376-1	[WJ1376-1 co-treated with TGFB1 protein] results in increased expression of CDH1 mRNA	24727557
C000588914	WJ1376-1	WJ1376-1 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	24727557
C000588915	WJ1398-1	WJ1398-1 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]	24727557
D000077191	Wortmannin	Wortmannin results in increased expression of CDH1 protein	25856345
C519885	WP1066	WP1066 inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]	28284859
C519885	WP1066	WP1066 inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]	24820114
C108830	Y 27632	Y 27632 results in decreased activity of CDH1 protein	16030252
C066632	yessotoxin	yessotoxin results in increased expression of CDH1 protein modified form	17118960
D015032	Zinc	Zinc deficiency results in increased expression of CDH1 mRNA	18356318
D015032	Zinc	Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein]	16844947
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of CDH1 mRNA	27215404

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0025	Alternative splicing
KW-0106	Calcium
KW-0130	Cell adhesion
KW-0965	Cell junction
KW-1003	Cell membrane
KW-0165	Cleavage on pair of basic residues
KW-0903	Direct protein sequencing
KW-0225	Disease mutation
KW-1015	Disulfide bond
KW-0038	Ectodermal dysplasia
KW-0967	Endosome
KW-0325	Glycoprotein
KW-0333	Golgi apparatus
KW-0472	Membrane
KW-0479	Metal-binding
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0677	Repeat
KW-0732	Signal
KW-0812	Transmembrane
KW-1133	Transmembrane helix
KW-0832	Ubl conjugation

Interpro

InterPro ID	InterPro Term
IPR039808	Cadherin
IPR002126	Cadherin-like_dom
IPR015919	Cadherin-like_sf
IPR020894	Cadherin_CS
IPR000233	Cadherin_cytoplasmic-dom
IPR014868	Cadherin_pro_dom
IPR027397	Catenin_binding_dom_sf

PROSITE

PROSITE ID	PROSITE Term
PS00232	CADHERIN_1
PS50268	CADHERIN_2

Pfam

Pfam ID	Pfam Term
PF00028	Cadherin
PF01049	Cadherin_C
PF08758	Cadherin_pro

Gene: CDH1

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Identified variants/mutations related to cleft phenotype

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction