| Tag | Content |
|---|---|
| Uniprot ID | P13631; B7Z492; B7Z4F1; B7ZAE4; J3KNP6; P22932; Q15281; Q52LZ8; Q9BYX8; Q9H1I3; Q9UJ38; |
| Entrez ID | 5916 |
| Genbank protein ID | AAA60253.1; BAH14630.1; AAH93729.1; CAB60726.1; AAA60254.1; BAH12537.1; AAG41595.1; AAA52692.1; BAH12478.1; EAW96676.1; AAA63254.1; AAG41594.2; CAA40548.1; AAH93727.1; |
| Genbank nucleotide ID | NM_001243730.1; NM_001042728.2; NM_000966.5; NM_001243732.1; |
| Ensembl protein ID | ENSP00000388510; ENSP00000343698; ENSP00000444335; ENSP00000377947; |
| Ensembl nucleotide ID | ENSG00000172819 |
| Gene name | Retinoic acid receptor gamma |
| Gene symbol | RARG |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). |
| Sequence | MATNKERLFA AGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG QPDLPKEMAS 60 LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY HYGVSSCEGC KGFFRRSIQK 120 NMVYTCHRDK NCIINKVTRN RCQYCRLQKC FEVGMSKEAV RNDRNKKKKE VKEEGSPDSY 180 ELSPQLEELI TKVSKAHQET FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK 240 IVEFAKRLPG FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH 300 NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV DKLQEPLLEA 360 LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL KMEIPGPMPP LIREMLENPE 420 MFEDDSSQPG PHPNASSEDE VPGGQGKGGL KSPA 454 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.