| Tag | Content |
|---|---|
| Uniprot ID | P15328; Q53EW2; Q6FGT8; Q6LC90; Q9UCT2; |
| Entrez ID | 2348 |
| Genbank protein ID | EAW74848.1; AAB39751.1; CAA44610.1; AAH02947.1; AAA74896.1; AAA35823.1; AAP35822.1; BAD97247.1; CAG46816.1; AAB39752.1; AAA35822.1; AAB05827.1; |
| Genbank nucleotide ID | NM_016725.2; NM_000802.3; NM_016724.2; NM_016729.2; |
| Ensembl protein ID | ENSP00000377286; ENSP00000377284; ENSP00000308137; ENSP00000377281; |
| Ensembl nucleotide ID | ENSG00000110195 |
| Gene name | Folate receptor alpha |
| Gene symbol | FOLR1 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
| Sequence | MAQRMTTQLL LLLVWVAVVG EAQTRIAWAR TELLNVCMNA KHHKEKPGPE DKLHEQCRPW 60 RKNACCSTNT SQEAHKDVSY LYRFNWNHCG EMAPACKRHF IQDTCLYECS PNLGPWIQQV 120 DQSWRKERVL NVPLCKEDCE QWWEDCRTSY TCKSNWHKGW NWTSGFNKCA VGAACQPFHF 180 YFPTPTVLCN EIWTHSYKVS NYSRGSGRCI QMWFDPAQGN PNEEVARFYA AAMSGAGPWA 240 AWPFLLSLAL MLLWLLS 257 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.