CleftGeneDB-Search

Gene: TIMP2

Basic information

Tag	Content
Uniprot ID	P16035; Q16121; Q93006; Q9UDF7;
Entrez ID	7077
Genbank protein ID	AAH52605.1; AAD14025.1; AAB19474.1; CAA38400.1; AAA59581.1; AAH71586.1; AAC50729.1; AAA61186.1;
Genbank nucleotide ID	NM_003255.4
Ensembl protein ID	ENSP00000262768
Ensembl nucleotide ID	ENSG00000035862
Gene name	Metalloproteinase inhibitor 2
Gene symbol	TIMP2
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Manually collected
Reference	21462296
Functional description	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Sequence	MGAAARTLRL ALGLLLLATL LRPADACSCS PVHPQQAFCN ADVVIRAKAV SEKEVDSGND 60 IYGNPIKRIQ YEIKQIKMFK GPEKDIEFIY TAPSSAVCGV SLDVGGKKEY LIAGKAEGDG 120 KMHITLCDFI VPWDTLSTTQ KKSLNHRYQM GCECKITRCP MIPCYISSPD ECLWMDWVTE 180 KNINGHQAKF FACIKRSDGS CAWYRGAAPP KQEFLDIEDP

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1BR9
1GXD
2TMP
4ILW
1BR9
1GXD

Protein disorder information

Protein disorder visualization from D2P2 is currently unavailable.

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Developmental stage	Species	Evidence	Details
1:1 ortholog	TIMP2	102178107	A0A452G0J3		Capra hircus	Prediction	More>>
1:1 ortholog	TIMP2	7077	P16035		Homo sapiens	Publication	More>>
1:1 ortholog	Timp2	21858	Q6PI17	E12.5, E13.5, E14.5	Mus musculus	Prediction	More>>
1:1 ortholog	TIMP2	743167	H2RHV1		Pan troglodytes	Prediction	More>>
1:1 ortholog	TIMP2	396988	C0JPM4		Sus scrofa	Prediction	More>>
1:1 ortholog	Timp2	29543	P30121		Rattus norvegicus	Prediction	More>>
1:1 ortholog	timp2a		Q1RLX2		Danio rerio	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
TIMP2	rs7502916A>C	Genotyping	21462296
TIMP2	rs4789936C>T	Genotyping	21462296
TIMP2	rs6501266C>T	Genotyping	21462296
TIMP2	rs7211674A>C	Genotyping	21462296
TIMP2	rs7212662T>G	Genotyping	21462296

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs989894792	p.Gly2Asp	missense variant	-	NC_000017.11:g.78925084C>T	TOPMed,gnomAD
rs1256421741	p.Ala3Val	missense variant	-	NC_000017.11:g.78925081G>A	TOPMed
rs1210843934	p.Ala3Thr	missense variant	-	NC_000017.11:g.78925082C>T	TOPMed,gnomAD
rs1418208704	p.Ala5Thr	missense variant	-	NC_000017.11:g.78925076C>T	TOPMed
rs1178979887	p.Ala5Val	missense variant	-	NC_000017.11:g.78925075G>A	TOPMed
rs1276073498	p.Arg6Cys	missense variant	-	NC_000017.11:g.78925073G>A	TOPMed,gnomAD
rs1276073498	p.Arg6Gly	missense variant	-	NC_000017.11:g.78925073G>C	TOPMed,gnomAD
rs957117975	p.Arg9Gln	missense variant	-	NC_000017.11:g.78925063C>T	TOPMed
rs1017940712	p.Ala11Val	missense variant	-	NC_000017.11:g.78925057G>A	TOPMed,gnomAD
rs1397601455	p.Leu14Phe	missense variant	-	NC_000017.11:g.78925049G>A	TOPMed,gnomAD
rs1397601455	p.Leu14Ile	missense variant	-	NC_000017.11:g.78925049G>T	TOPMed,gnomAD
rs1376669167	p.Leu16Val	missense variant	-	NC_000017.11:g.78925043G>C	TOPMed,gnomAD
rs1376669167	p.Leu16Met	missense variant	-	NC_000017.11:g.78925043G>T	TOPMed,gnomAD
rs1302248958	p.Ala18Gly	missense variant	-	NC_000017.11:g.78925036G>C	TOPMed,gnomAD
rs1302248958	p.Ala18Glu	missense variant	-	NC_000017.11:g.78925036G>T	TOPMed,gnomAD
rs1031019474	p.Pro23Ser	missense variant	-	NC_000017.11:g.78925022G>A	TOPMed,gnomAD
rs1428089507	p.Ala24Val	missense variant	-	NC_000017.11:g.78925018G>A	gnomAD
rs1165727821	p.Asp25Asn	missense variant	-	NC_000017.11:g.78925016C>T	gnomAD
rs1425988221	p.Cys27Arg	missense variant	-	NC_000017.11:g.78925010A>G	gnomAD
rs557766081	p.Ser30Thr	missense variant	-	NC_000017.11:g.78925001A>T	1000Genomes
rs1181798203	p.Pro31Gln	missense variant	-	NC_000017.11:g.78924997G>T	TOPMed,gnomAD
rs1181798203	p.Pro31Arg	missense variant	-	NC_000017.11:g.78924997G>C	TOPMed,gnomAD
rs1253377450	p.Pro34Leu	missense variant	-	NC_000017.11:g.78924988G>A	gnomAD
rs1429193229	p.Gln36Lys	missense variant	-	NC_000017.11:g.78924983G>T	TOPMed
rs1364756800	p.Ala37Gly	missense variant	-	NC_000017.11:g.78924979G>C	gnomAD
COSM4070228	p.Ala47Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000017.11:g.78873910G>A	NCI-TCGA Cosmic
rs755731698	p.Ala47Thr	missense variant	-	NC_000017.11:g.78873911C>T	ExAC,gnomAD
rs1435606592	p.Ala49Val	missense variant	-	NC_000017.11:g.78873904G>A	gnomAD
rs781341882	p.Glu52Gly	missense variant	-	NC_000017.11:g.78873895T>C	ExAC,gnomAD
rs1378758449	p.Lys53Met	missense variant	-	NC_000017.11:g.78873892T>A	TOPMed,gnomAD
rs1454985792	p.Gly58Arg	missense variant	-	NC_000017.11:g.78873878C>T	gnomAD
NCI-TCGA novel	p.Asn64Lys	missense variant	-	NC_000017.11:g.78873858G>C	NCI-TCGA
rs373951222	p.Pro65Ala	missense variant	-	NC_000017.11:g.78873857G>C	ESP,TOPMed,gnomAD
rs1477964795	p.Pro65Arg	missense variant	-	NC_000017.11:g.78873856G>C	gnomAD
rs1410997894	p.Ile66Met	missense variant	-	NC_000017.11:g.78873852G>C	TOPMed
NCI-TCGA novel	p.Glu72Asp	missense variant	-	NC_000017.11:g.78873834C>A	NCI-TCGA
rs541162688	p.Ile73Met	missense variant	-	NC_000017.11:g.78873831G>C	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Gln75Pro	missense variant	-	NC_000017.11:g.78873826T>G	NCI-TCGA
NCI-TCGA novel	p.Ile76Lys	missense variant	-	NC_000017.11:g.78873823A>T	NCI-TCGA
rs764543713	p.Pro82Ser	missense variant	-	NC_000017.11:g.78870994G>A	ExAC,gnomAD
COSM4890902	p.Glu83Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000017.11:g.78870991C>G	NCI-TCGA Cosmic
COSM5436940	p.Glu83Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000017.11:g.78870989C>A	NCI-TCGA Cosmic
rs1422334761	p.Lys84Asn	missense variant	-	NC_000017.11:g.78870986C>G	gnomAD
rs1214418388	p.Asp85Val	missense variant	-	NC_000017.11:g.78870984T>A	TOPMed
NCI-TCGA novel	p.Ile89Met	missense variant	-	NC_000017.11:g.78870971G>C	NCI-TCGA
rs374979973	p.Tyr90Cys	missense variant	-	NC_000017.11:g.78870969T>C	NCI-TCGA
rs374979973	p.Tyr90Phe	missense variant	-	NC_000017.11:g.78870969T>A	ESP,ExAC,TOPMed,gnomAD
rs374979973	p.Tyr90Cys	missense variant	-	NC_000017.11:g.78870969T>C	ESP,ExAC,TOPMed,gnomAD
rs761108430	p.Tyr90His	missense variant	-	NC_000017.11:g.78870970A>G	ExAC,gnomAD
rs1253720535	p.Thr91Ala	missense variant	-	NC_000017.11:g.78870967T>C	gnomAD
NCI-TCGA novel	p.Ala92ProPheSerTerUnkUnk	frameshift	-	NC_000017.11:g.78870959_78870965GGGGGCC>-	NCI-TCGA
rs372752139	p.Pro93Arg	missense variant	-	NC_000017.11:g.78870960G>C	ESP,ExAC,gnomAD
rs747597238	p.Ser94Ala	missense variant	-	NC_000017.11:g.78870958A>C	ExAC,gnomAD
rs867357033	p.Ser94Phe	missense variant	-	NC_000017.11:g.78870957G>A	-
rs867357033	p.Ser94Phe	missense variant	-	NC_000017.11:g.78870957G>A	NCI-TCGA
rs1273715615	p.Ser95Leu	missense variant	-	NC_000017.11:g.78870954G>A	NCI-TCGA
rs1273715615	p.Ser95Leu	missense variant	-	NC_000017.11:g.78870954G>A	gnomAD
rs746899595	p.Val97Met	missense variant	-	NC_000017.11:g.78870949C>T	ExAC,gnomAD
rs779039090	p.Val100Phe	missense variant	-	NC_000017.11:g.78870940C>A	ExAC,gnomAD
rs779039090	p.Val100Ile	missense variant	-	NC_000017.11:g.78870940C>T	ExAC,gnomAD
rs368947971	p.Ser101Leu	missense variant	-	NC_000017.11:g.78870936G>A	NCI-TCGA,NCI-TCGA Cosmic
rs368947971	p.Ser101Leu	missense variant	-	NC_000017.11:g.78870936G>A	ESP,TOPMed,gnomAD
NCI-TCGA novel	p.Asp103Gly	missense variant	-	NC_000017.11:g.78870930T>C	NCI-TCGA
rs963112143	p.Val104Ile	missense variant	-	NC_000017.11:g.78870928C>T	TOPMed,gnomAD
rs753866027	p.Val104Ala	missense variant	-	NC_000017.11:g.78870927A>G	ExAC
rs753866027	p.Val104Gly	missense variant	-	NC_000017.11:g.78870927A>C	ExAC
NCI-TCGA novel	p.Gly106Glu	missense variant	-	NC_000017.11:g.78870921C>T	NCI-TCGA
NCI-TCGA novel	p.Glu109Ala	missense variant	-	NC_000017.11:g.78870912T>G	NCI-TCGA
NCI-TCGA novel	p.Tyr110Ser	missense variant	-	NC_000017.11:g.78870909T>G	NCI-TCGA
rs1163662057	p.Ala113Val	missense variant	-	NC_000017.11:g.78870900G>A	gnomAD
rs774312475	p.Gly114Ala	missense variant	-	NC_000017.11:g.78857646C>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala116Val	missense variant	-	NC_000017.11:g.78857640G>A	NCI-TCGA
rs780171870	p.Glu117Lys	missense variant	-	NC_000017.11:g.78857638C>T	ExAC,TOPMed,gnomAD
rs780171870	p.Glu117Lys	missense variant	-	NC_000017.11:g.78857638C>T	NCI-TCGA,NCI-TCGA Cosmic
rs1295978233	p.Gly118Arg	missense variant	-	NC_000017.11:g.78857635C>T	gnomAD
rs141084603	p.Asp119Tyr	missense variant	-	NC_000017.11:g.78857632C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Asp119GlyPheSerTerUnkUnk	frameshift	-	NC_000017.11:g.78857631_78857632insC	NCI-TCGA
rs748140299	p.Gly120Ser	missense variant	-	NC_000017.11:g.78857629C>T	ExAC,gnomAD
NCI-TCGA novel	p.Gly120Asp	missense variant	-	NC_000017.11:g.78857628C>T	NCI-TCGA
rs368210736	p.Lys121Arg	missense variant	-	NC_000017.11:g.78857625T>C	ESP,ExAC,TOPMed,gnomAD
rs1193724527	p.Ile124Val	missense variant	-	NC_000017.11:g.78857617T>C	gnomAD
rs151117827	p.Thr125Ile	missense variant	-	NC_000017.11:g.78857613G>A	ESP,ExAC,gnomAD
rs151117827	p.Thr125Ile	missense variant	-	NC_000017.11:g.78857613G>A	NCI-TCGA
rs1190296931	p.Phe129Val	missense variant	-	NC_000017.11:g.78857602A>C	TOPMed
rs145756196	p.Ile130Met	missense variant	-	NC_000017.11:g.78857597G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs564017292	p.Val131Met	missense variant	-	NC_000017.11:g.78857596C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs564017292	p.Val131Leu	missense variant	-	NC_000017.11:g.78857596C>G	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Val131Ala	missense variant	-	NC_000017.11:g.78857595A>G	NCI-TCGA
rs1488109108	p.Pro132Leu	missense variant	-	NC_000017.11:g.78857592G>A	gnomAD
rs752340133	p.Thr135Ser	missense variant	-	NC_000017.11:g.78857584T>A	ExAC,gnomAD
rs1343309412	p.Thr135Ile	missense variant	-	NC_000017.11:g.78857583G>A	gnomAD
rs752340133	p.Thr135Ala	missense variant	-	NC_000017.11:g.78857584T>C	ExAC,gnomAD
rs759112616	p.Leu136Met	missense variant	-	NC_000017.11:g.78857581G>T	ExAC,gnomAD
rs774255476	p.Thr138Ile	missense variant	-	NC_000017.11:g.78857574G>A	ExAC,gnomAD
rs1319416210	p.Thr138Ala	missense variant	-	NC_000017.11:g.78857575T>C	gnomAD
COSM985281	p.Thr139Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000017.11:g.78857572T>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ser143Asn	missense variant	-	NC_000017.11:g.78857559C>T	NCI-TCGA
rs544106882	p.His146Arg	missense variant	-	NC_000017.11:g.78857550T>C	1000Genomes,ExAC,gnomAD
rs750649540	p.Glu153Lys	missense variant	-	NC_000017.11:g.78857530C>T	NCI-TCGA
rs750649540	p.Glu153Lys	missense variant	-	NC_000017.11:g.78857530C>T	-
rs143729470	p.Thr157Met	missense variant	-	NC_000017.11:g.78855860G>A	ESP,ExAC,TOPMed,gnomAD
rs1358820636	p.Arg158His	missense variant	-	NC_000017.11:g.78855857C>T	TOPMed,gnomAD
rs1358820636	p.Arg158Leu	missense variant	-	NC_000017.11:g.78855857C>A	TOPMed,gnomAD
rs775894136	p.Arg158Cys	missense variant	-	NC_000017.11:g.78855858G>A	ExAC,gnomAD
rs772274106	p.Pro160Leu	missense variant	-	NC_000017.11:g.78855851G>A	ExAC,gnomAD
rs148747195	p.Met161Thr	missense variant	-	NC_000017.11:g.78855848A>G	ESP,ExAC,TOPMed,gnomAD
rs774860290	p.Met161Ile	missense variant	-	NC_000017.11:g.78855847C>T	ExAC,TOPMed,gnomAD
rs1172701741	p.Met161Val	missense variant	-	NC_000017.11:g.78855849T>C	TOPMed
rs774860290	p.Met161Ile	missense variant	-	NC_000017.11:g.78855847C>G	ExAC,TOPMed,gnomAD
rs771343314	p.Pro163Leu	missense variant	-	NC_000017.11:g.78855842G>A	ExAC,gnomAD
rs944053311	p.Tyr165His	missense variant	-	NC_000017.11:g.78855837A>G	gnomAD
rs1046955427	p.Ser168Phe	missense variant	-	NC_000017.11:g.78855827G>A	TOPMed
rs1046955427	p.Ser168Tyr	missense variant	-	NC_000017.11:g.78855827G>T	TOPMed
NCI-TCGA novel	p.Pro169Gln	missense variant	-	NC_000017.11:g.78855824G>T	NCI-TCGA
rs201018196	p.Pro169Leu	missense variant	-	NC_000017.11:g.78855824G>A	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Asp170Asn	missense variant	-	NC_000017.11:g.78855822C>T	NCI-TCGA
rs769578055	p.Leu173Pro	missense variant	-	NC_000017.11:g.78855812A>G	ExAC,TOPMed,gnomAD
rs1366219491	p.Met175Val	missense variant	-	NC_000017.11:g.78855807T>C	gnomAD
rs917627335	p.Glu180Gly	missense variant	-	NC_000017.11:g.78855791T>C	TOPMed
rs1344433839	p.Glu180Lys	missense variant	-	NC_000017.11:g.78855792C>T	gnomAD
rs757916824	p.Asn184Ser	missense variant	-	NC_000017.11:g.78855779T>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gly185Glu	missense variant	-	NC_000017.11:g.78855776C>T	NCI-TCGA
rs370391888	p.Ala188Thr	missense variant	-	NC_000017.11:g.78855768C>T	ESP,ExAC,gnomAD
NCI-TCGA novel	p.Ala188Val	missense variant	-	NC_000017.11:g.78855767G>A	NCI-TCGA
rs753641012	p.Ala192Thr	missense variant	-	NC_000017.11:g.78855756C>T	ExAC,TOPMed,gnomAD
rs1173847302	p.Cys193Ser	missense variant	-	NC_000017.11:g.78855752C>G	TOPMed
rs1172257519	p.Lys195Asn	missense variant	-	NC_000017.11:g.78855745C>G	gnomAD
rs956450165	p.Gly199Asp	missense variant	-	NC_000017.11:g.78855734C>T	TOPMed
rs1235478767	p.Ala202Val	missense variant	-	NC_000017.11:g.78855725G>A	gnomAD
rs1484122131	p.Ala202Thr	missense variant	-	NC_000017.11:g.78855726C>T	TOPMed,gnomAD
rs759589817	p.Tyr204Ter	stop gained	-	NC_000017.11:g.78855718G>C	ExAC,gnomAD
rs774322385	p.Arg205Cys	missense variant	-	NC_000017.11:g.78855717G>A	ExAC,gnomAD
rs771417379	p.Arg205His	missense variant	-	NC_000017.11:g.78855716C>T	ExAC,gnomAD
rs773751172	p.Gly206Ser	missense variant	-	NC_000017.11:g.78855714C>T	ExAC,TOPMed,gnomAD
rs201845164	p.Ala207Thr	missense variant	-	NC_000017.11:g.78855711C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs775066324	p.Ala207Gly	missense variant	-	NC_000017.11:g.78855710G>C	ExAC,TOPMed,gnomAD
rs775066324	p.Ala207Val	missense variant	-	NC_000017.11:g.78855710G>A	ExAC,TOPMed,gnomAD
rs745343765	p.Ala208Val	missense variant	-	NC_000017.11:g.78855707G>A	ExAC,TOPMed,gnomAD
rs997866208	p.Pro209Leu	missense variant	-	NC_000017.11:g.78855704G>A	TOPMed
rs1463612469	p.Pro209Ser	missense variant	-	NC_000017.11:g.78855705G>A	gnomAD
rs1165072095	p.Pro210Arg	missense variant	-	NC_000017.11:g.78855701G>C	gnomAD
NCI-TCGA novel	p.Lys211SerPheSerTerUnkUnk	frameshift	-	NC_000017.11:g.78855700G>-	NCI-TCGA
rs756830236	p.Glu213Lys	missense variant	-	NC_000017.11:g.78855693C>T	ExAC,TOPMed,gnomAD
rs570205003	p.Asp216His	missense variant	-	NC_000017.11:g.78855684C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs570205003	p.Asp216Asn	missense variant	-	NC_000017.11:g.78855684C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs578083142	p.Ile217Leu	missense variant	-	NC_000017.11:g.78855681T>G	ExAC,gnomAD
rs578083142	p.Ile217Val	missense variant	-	NC_000017.11:g.78855681T>C	ExAC,gnomAD
rs1250792593	p.Glu218Lys	missense variant	-	NC_000017.11:g.78855678C>T	gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0000786	Spontaneous abortion	phenotype	CTD_human
C0000822	Abortion, Tubal	disease	CTD_human
C0001342	Acute periodontitis	disease	BEFREE
C0001418	Adenocarcinoma	group	BEFREE
C0002152	Alloxan Diabetes	disease	CTD_human
C0002395	Alzheimer's Disease	disease	BEFREE;LHGDN
C0002448	Ameloblastoma	disease	BEFREE
C0002736	Amyotrophic Lateral Sclerosis	disease	BEFREE
C0002940	Aneurysm	phenotype	BEFREE
C0003855	Arteriovenous fistula	phenotype	BEFREE
C0003864	Arthritis	disease	BEFREE
C0003872	Arthritis, Psoriatic	disease	BEFREE
C0003873	Rheumatoid Arthritis	disease	BEFREE
C0004114	Astrocytoma	disease	BEFREE
C0004238	Atrial Fibrillation	disease	BEFREE
C0005398	Cholestasis, Extrahepatic	disease	CTD_human
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE;LHGDN
C0006118	Brain Neoplasms	group	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0006287	Bronchopulmonary Dysplasia	disease	LHGDN
C0006663	Calcinosis	phenotype	CTD_human
C0007102	Malignant tumor of colon	disease	BEFREE
C0007103	Malignant neoplasm of endometrium	disease	BEFREE
C0007113	Rectal Carcinoma	disease	BEFREE
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE;LHGDN
C0007134	Renal Cell Carcinoma	disease	BEFREE;LHGDN
C0007137	Squamous cell carcinoma	disease	BEFREE;LHGDN
C0007194	Hypertrophic Cardiomyopathy	disease	LHGDN
C0007766	Intracranial Aneurysm	disease	BEFREE;LHGDN;RGD
C0007847	Malignant tumor of cervix	disease	BEFREE
C0008497	Choriocarcinoma	disease	BEFREE
C0009375	Colonic Neoplasms	group	BEFREE
C0009402	Colorectal Carcinoma	disease	BEFREE
C0009404	Colorectal Neoplasms	group	LHGDN
C0011334	Dental caries	disease	BEFREE
C0011847	Diabetes	disease	BEFREE
C0011849	Diabetes Mellitus	group	BEFREE
C0011853	Diabetes Mellitus, Experimental	disease	CTD_human
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	disease	BEFREE
C0011881	Diabetic Nephropathy	disease	BEFREE;LHGDN
C0013264	Muscular Dystrophy, Duchenne	disease	BEFREE;LHGDN
C0013312	Dupuytren Contracture	disease	GWASCAT;GWASDB
C0013720	Ehlers-Danlos Syndrome	disease	BEFREE
C0014118	Endocarditis	disease	BEFREE
C0014175	Endometriosis	disease	BEFREE;LHGDN
C0014859	Esophageal Neoplasms	group	BEFREE
C0016057	Fibrosarcoma	disease	BEFREE
C0017636	Glioblastoma	disease	BEFREE
C0017638	Glioma	disease	BEFREE
C0018801	Heart failure	disease	RGD
C0018802	Congestive heart failure	disease	RGD
C0018916	Hemangioma	disease	BEFREE
C0019080	Hemorrhage	phenotype	LHGDN
C0019214	Hepatosplenomegaly	phenotype	BEFREE
C0019284	Diaphragmatic Hernia	phenotype	LHGDN
C0019294	Hernia, Inguinal	phenotype	LHGDN
C0019348	Herpes Simplex Infections	group	BEFREE
C0019693	HIV Infections	group	BEFREE
C0019829	Hodgkin Disease	disease	BEFREE;LHGDN
C0020179	Huntington Disease	disease	LHGDN
C0020541	Hypertension, Portal	disease	RGD
C0021053	Immune System Diseases	group	BEFREE
C0021390	Inflammatory Bowel Diseases	group	BEFREE
C0022660	Kidney Failure, Acute	disease	BEFREE
C0022661	Kidney Failure, Chronic	disease	BEFREE
C0023267	Fibroid Tumor	group	BEFREE
C0023418	leukemia	disease	BEFREE
C0023449	Acute lymphocytic leukemia	disease	BEFREE
C0023465	Acute monocytic leukemia	disease	BEFREE
C0023467	Leukemia, Myelocytic, Acute	disease	BEFREE
C0023473	Myeloid Leukemia, Chronic	disease	BEFREE
C0023890	Liver Cirrhosis	disease	BEFREE
C0023893	Liver Cirrhosis, Experimental	disease	CTD_human
C0023903	Liver neoplasms	group	BEFREE
C0024117	Chronic Obstructive Airway Disease	disease	BEFREE
C0024299	Lymphoma	group	BEFREE
C0024305	Lymphoma, Non-Hodgkin	disease	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0024796	Marfan Syndrome	disease	BEFREE
C0025202	melanoma	disease	BEFREE;LHGDN
C0025286	Meningioma	disease	BEFREE
C0025297	Viral meningitis	disease	LHGDN
C0026277	Mixed Salivary Gland Tumor	disease	BEFREE
C0026618	Dental Fluorosis, Acquired	disease	BEFREE
C0026654	Moyamoya Disease	disease	BEFREE;LHGDN
C0026691	Mucocutaneous Lymph Node Syndrome	disease	BEFREE
C0026764	Multiple Myeloma	disease	LHGDN
C0026769	Multiple Sclerosis	disease	BEFREE;LHGDN
C0027051	Myocardial Infarction	disease	CTD_human
C0027092	Myopia	disease	BEFREE
C0027627	Neoplasm Metastasis	phenotype	BEFREE;LHGDN
C0027819	Neuroblastoma	group	BEFREE
C0027868	Neuromuscular Diseases	group	LHGDN
C0028797	Occupational Diseases	group	CTD_human
C0029408	Degenerative polyarthritis	disease	BEFREE
C0029456	Osteoporosis	disease	BEFREE
C0029463	Osteosarcoma	disease	BEFREE
C0029925	Ovarian Carcinoma	disease	BEFREE
C0030297	Pancreatic Neoplasm	disease	BEFREE
C0030567	Parkinson Disease	disease	BEFREE
C0031099	Periodontitis	disease	BEFREE
C0031106	Periodontitis, Juvenile	disease	BEFREE
C0032000	Pituitary Adenoma	disease	BEFREE
C0032226	Pleural Diseases	group	CTD_human
C0032914	Pre-Eclampsia	phenotype	LHGDN
C0033141	Cardiomyopathies, Primary	group	RGD
C0033578	Prostatic Neoplasms	group	BEFREE;LHGDN
C0033999	Pterygium	disease	BEFREE
C0034067	Pulmonary Emphysema	disease	BEFREE
C0035334	Retinitis Pigmentosa	disease	BEFREE
C0035369	Retroviridae Infections	group	BEFREE
C0036421	Systemic Scleroderma	disease	BEFREE;LHGDN
C0036529	Myocardial Diseases, Secondary	group	RGD
C0037286	Skin Neoplasms	group	BEFREE;LHGDN
C0038356	Stomach Neoplasms	group	LHGDN
C0038433	Streptozotocin Diabetes	disease	CTD_human
C0038454	Cerebrovascular accident	group	BEFREE
C0041582	Ulcer	disease	BEFREE
C0042133	Uterine Fibroids	group	BEFREE
C0079474	Hallopeau-Siemens Disease	disease	BEFREE
C0079731	B-Cell Lymphomas	group	BEFREE
C0080032	Pleural Effusion, Malignant	disease	BEFREE
C0085437	Meningitis, Bacterial	group	LHGDN
C0085669	Acute leukemia	disease	BEFREE
C0149721	Left Ventricular Hypertrophy	disease	BEFREE
C0151936	Disorder of tendon	group	BEFREE
C0152013	Adenocarcinoma of lung (disorder)	disease	BEFREE
C0152018	Esophageal carcinoma	disease	BEFREE
C0152105	Hypertensive heart disease	disease	BEFREE
C0153452	Malignant neoplasm of gallbladder	disease	BEFREE
C0153676	Secondary malignant neoplasm of lung	disease	BEFREE
C0155094	Corneal pannus	disease	BEFREE
C0158646	Cleft palate with cleft lip	disease	BEFREE
C0162871	Aortic Aneurysm, Abdominal	disease	BEFREE
C0206731	Angiofibroma	disease	BEFREE
C0235782	Gallbladder Carcinoma	disease	BEFREE
C0235974	Pancreatic carcinoma	disease	BEFREE
C0239946	Fibrosis, Liver	disease	BEFREE
C0241982	Bulla of lung	disease	BEFREE
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0243026	Sepsis	disease	LHGDN
C0243038	Carcinoma, Lewis Lung	disease	BEFREE
C0263628	Tumoral calcinosis	disease	CTD_human
C0263746	Osteoarthritis of the hand	disease	BEFREE
C0266929	Chronic Periodontitis	disease	BEFREE
C0268800	Simple renal cyst	disease	BEFREE
C0271183	Severe myopia	disease	BEFREE
C0275904	Tuberculosis, Central Nervous System	disease	BEFREE
C0278701	Gastric Adenocarcinoma	disease	BEFREE
C0278996	Malignant Head and Neck Neoplasm	disease	BEFREE
C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	disease	BEFREE
C0280220	stage, ovarian epithelial cancer	disease	BEFREE
C0280324	Laryngeal Squamous Cell Carcinoma	disease	BEFREE
C0302592	Cervix carcinoma	disease	BEFREE
C0333297	Chronic ulcer	disease	BEFREE
C0333519	Caries (morphologic abnormality)	disease	BEFREE
C0339525	Autosomal dominant retinitis pigmentosa	disease	BEFREE
C0341106	Eosinophilic esophagitis	disease	GWASCAT
C0341858	Endometriosis of uterus	disease	BEFREE
C0345904	Malignant neoplasm of liver	disease	BEFREE
C0345967	Malignant mesothelioma	disease	BEFREE
C0346300	Pituitary carcinoma	disease	BEFREE
C0346647	Malignant neoplasm of pancreas	disease	BEFREE
C0349516	Isolated aortic stenosis	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0476089	Endometrial Carcinoma	disease	BEFREE
C0494165	Secondary malignant neoplasm of liver	disease	BEFREE
C0521174	Microcalcification	phenotype	CTD_human
C0524909	Hepatitis B, Chronic	disease	LHGDN
C0543822	Atherosclerotic occlusive disease	disease	BEFREE
C0546837	Malignant neoplasm of esophagus	disease	BEFREE
C0549473	Thyroid carcinoma	disease	BEFREE
C0555198	Malignant Glioma	disease	BEFREE
C0585442	Osteosarcoma of bone	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0677886	Epithelial ovarian cancer	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0684249	Carcinoma of lung	disease	BEFREE
C0686619	Secondary malignant neoplasm of lymph node	disease	BEFREE
C0687120	Nephronophthisis	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0700095	Central neuroblastoma	disease	BEFREE
C0852036	Pregnancy associated hypertension	disease	LHGDN
C0853879	Invasive carcinoma of breast	disease	BEFREE
C0856742	Post MI	phenotype	BEFREE
C0878544	Cardiomyopathies	group	RGD
C0919267	ovarian neoplasm	disease	LHGDN
C0948008	Ischemic stroke	disease	BEFREE
C0948089	Acute Coronary Syndrome	disease	BEFREE;LHGDN
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1168401	Squamous cell carcinoma of the head and neck	disease	BEFREE
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1306557	Chronic venous insufficiency	disease	BEFREE
C1318544	M5b Acute differentiated monocytic leukemia	disease	BEFREE
C1333990	Hereditary Nonpolyposis Colorectal Cancer	disease	BEFREE
C1334274	Invasive Carcinoma	phenotype	BEFREE
C1368683	Epithelioma	disease	BEFREE
C1397307	Cardiac fibrosis	disease	BEFREE
C1458155	Mammary Neoplasms	group	BEFREE;LHGDN
C1510475	Diverticulosis	disease	BEFREE
C1511789	Desmoplastic	disease	BEFREE
C1519678	Tumor Expansion	phenotype	BEFREE
C1527249	Colorectal Cancer	disease	BEFREE
C1559154	Rash and Dermatitis Adverse Event Associated with Chemoradiation	disease	BEFREE
C1568272	Tendinopathy	disease	BEFREE
C1658953	tumor vasculature	phenotype	BEFREE
C1719495	Aggressive periodontitis, generalized	disease	BEFREE
C1762616	Meningioma, benign, no ICD-O subtype	disease	BEFREE
C1868193	PNEUMOTHORAX, PRIMARY SPONTANEOUS	disease	BEFREE
C1883486	Uterine Corpus Cancer	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE;LHGDN
C2316810	Chronic kidney disease stage 5	disease	BEFREE
C2700366	Adiponectin Measurement	phenotype	GWASDB
C2931384	Moyamoya disease 1	disease	BEFREE
C3258293	Valvular disease	disease	BEFREE
C3463824	MYELODYSPLASTIC SYNDROME	group	BEFREE
C3665629	Dental fluorosis	disease	BEFREE
C3887486	Interstitial lung fibrosis	phenotype	BEFREE
C3887499	Renal cyst	phenotype	BEFREE
C4048328	cervical cancer	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0002020	protease binding	IBA
GO:0002020	protease binding	IPI
GO:0005178	integrin binding	IEA
GO:0005515	protein binding	IPI
GO:0008191	metalloendopeptidase inhibitor activity	IBA
GO:0008270	zinc ion binding	IDA
GO:0030414	peptidase inhibitor activity	IDA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0007417	central nervous system development	IEA
GO:0007568	aging	IEA
GO:0008285	negative regulation of cell population proliferation	IEA
GO:0009725	response to hormone	IBA
GO:0010033	response to organic substance	IBA
GO:0010951	negative regulation of endopeptidase activity	IBA
GO:0022617	extracellular matrix disassembly	TAS
GO:0032487	regulation of Rap protein signal transduction	IEA
GO:0034097	response to cytokine	IBA
GO:0042493	response to drug	IEA
GO:0043312	neutrophil degranulation	TAS
GO:0043410	positive regulation of MAPK cascade	IEA
GO:0045666	positive regulation of neuron differentiation	IEA
GO:0045762	positive regulation of adenylate cyclase activity	IEA
GO:0045930	negative regulation of mitotic cell cycle	IEA
GO:0046580	negative regulation of Ras protein signal transduction	IEA
GO:0051045	negative regulation of membrane protein ectodomain proteolysis	IBA
GO:1905049	negative regulation of metallopeptidase activity	IDA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IBA
GO:0009986	cell surface	IEA
GO:0030426	growth cone	IEA
GO:0031012	extracellular matrix	IBA
GO:0035580	specific granule lumen	TAS
GO:0043025	neuronal cell body	IEA
GO:0062023	collagen-containing extracellular matrix	HDA
GO:1904724	tertiary granule lumen	TAS
GO:1904813	ficolin-1-rich granule lumen	TAS

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1592389	Activation of Matrix Metalloproteinases	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	1,2-dithiol-3-thione results in decreased expression of TIMP2 mRNA	19162173
C038983	1,3-dimethylthiourea	1,3-dimethylthiourea inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	11682029
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA]	16054899
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of TIMP2 mRNA	19883732
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of TIMP2 protein	19883732
D015655	1-Methyl-4-phenylpyridinium	TIMP2 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium	19883732
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of TIMP2 mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of TIMP2 mRNA	25380136
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of TIMP2 mRNA	25827057
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of TIMP2 mRNA	25827057
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TIMP2 mRNA	19167446
C013186	2,3-pentanedione	2,3-pentanedione results in increased expression of TIMP2 mRNA	25710175
D015650	24,25-Dihydroxyvitamin D 3	24,25-Dihydroxyvitamin D 3 results in decreased expression of TIMP2 protein	18379402
C010914	2,4-diaminotoluene	2,4-diaminotoluene results in decreased expression of TIMP2 mRNA	22016648
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene results in decreased expression of TIMP2 mRNA	16917068
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA]	19956873
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein]	19956873
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA]	19956873
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein]	19956873
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]	19956873
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]	19956873
C079315	2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid	2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	16033810
C488288	2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid	[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with VEGFA protein] results in increased expression of TIMP2 protein	25447407
C026308	3,4-dihydrocoumarin	3,4-dihydrocoumarin results in decreased expression of TIMP2 mRNA	22016648
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of TIMP2 mRNA	16788091
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in decreased expression of TIMP2 mRNA	18648102
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of TIMP2 mRNA	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP2 mRNA	27188386
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of TIMP2 mRNA	20829426
C080669	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TIMP2 protein	22245252
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 mRNA	21294050; 22485181;
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 protein	21294050; 22485181;
D015127	9,10-Dimethyl-1,2-benzanthracene	chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 mRNA]	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 protein]	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 protein]	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 mRNA]	21294050
D015127	9,10-Dimethyl-1,2-benzanthracene	Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 protein]	21294050
C496492	abrine	abrine results in decreased expression of TIMP2 mRNA	31054353
D000079	Acetaldehyde	Acetaldehyde results in increased expression of TIMP2 protein	12524413
D000082	Acetaminophen	Acetaminophen results in increased expression of TIMP2 mRNA	22230336
D000336	Aerosols	Aerosols results in increased expression of TIMP2 mRNA	29505817
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of TIMP2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of TIMP2 intron	30157460
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TIMP2 mRNA	19770486
D000393	Air Pollutants	[Glucose co-treated with Air Pollutants] results in decreased expression of TIMP2 mRNA	26179980
D000551	Ambroxol	Ambroxol affects the reaction [Paraquat results in increased expression of TIMP2 mRNA]	21921364
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of TIMP2 mRNA	16483693
D000661	Amphetamine	Amphetamine results in increased expression of TIMP2 mRNA	30779732
D001151	Arsenic	Arsenic affects the expression of TIMP2 protein	24675094
D001151	Arsenic	Arsenic affects the methylation of TIMP2 gene	25304211
D001151	Arsenic	Arsenic results in decreased expression of TIMP2 mRNA	19654921
C025657	arsenic acid	arsenic acid results in increased expression of TIMP2 mRNA	18296743
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of TIMP2 mRNA	15962302; 16624393; 22521957;
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of TIMP2 protein	15962302; 16624393;
C015001	arsenite	arsenite results in decreased expression of TIMP2 mRNA	18296743
D001194	Asbestos	TIMP2 gene SNP affects the susceptibility to Asbestos	24142982
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in increased expression of TIMP2	16574944
D001241	Aspirin	Aspirin results in decreased expression of TIMP2 mRNA	15928584
D001241	Aspirin	Aspirin results in increased expression of TIMP2 mRNA	18971601
D001280	Atrazine	Atrazine results in decreased expression of TIMP2 mRNA	25929836
C547126	AZM551248	AZM551248 results in increased expression of TIMP2 mRNA	22323515
D001397	Azoxymethane	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TIMP2 mRNA	29950665
C080985	batimastat	batimastat results in decreased activity of TIMP2 protein	15632106
C044946	benazepril	benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]	16732983; 20821936;
C044946	benazepril	benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein]	16732983; 20821936;
D001542	Benomyl	Benomyl results in increased expression of TIMP2 mRNA	25530041
D001554	Benzene	Benzene results in decreased expression of TIMP2 mRNA	31154059
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of TIMP2 mRNA	31154059
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TIMP2 mRNA	20106945; 21632981; 22316170;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TIMP2 protein	20719421
D001564	Benzo(a)pyrene	[Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of TIMP2 protein	20719421
C026487	benzo(e)pyrene	benzo(e)pyrene results in increased methylation of TIMP2 intron	30157460
C002503	betulin	betulin inhibits the reaction [Ethanol results in increased expression of TIMP2 protein]	21172400
C002070	betulinic acid	betulinic acid inhibits the reaction [Ethanol results in increased expression of TIMP2 protein]	21172400
D001629	Bezafibrate	Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA]	18513333
C034786	bis(4-hydroxycinnamoyl)methane	bis(4-hydroxycinnamoyl)methane results in decreased expression of TIMP2 protein	18495463
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of TIMP2 mRNA	30951980
C006780	bisphenol A	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA]	19956873
C006780	bisphenol A	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein]	19956873
C006780	bisphenol A	bisphenol A results in increased expression of TIMP2 mRNA	19956873
C006780	bisphenol A	bisphenol A results in increased expression of TIMP2 protein	19956873
C006780	bisphenol A	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA]	19956873
C006780	bisphenol A	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein]	19956873
C006780	bisphenol A	bisphenol A results in decreased expression of TIMP2 mRNA	12233820
C006780	bisphenol A	bisphenol A results in increased expression of TIMP2 mRNA	30303745; 30951980;
C006780	bisphenol A	bisphenol A results in decreased expression of TIMP2 mRNA	27925325; 30816183;
C006780	bisphenol A	bisphenol A results in increased expression of TIMP2 mRNA	25181051
C006780	bisphenol A	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of TIMP2 mRNA]	19228888
C000611646	bisphenol F	bisphenol F results in increased expression of TIMP2 mRNA	30951980
D002104	Cadmium	Cadmium results in decreased expression of TIMP2 mRNA	31154059
D019256	Cadmium Chloride	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of TIMP2 mRNA	19840844
D019256	Cadmium Chloride	[Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of TIMP2 protein	20719421
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of TIMP2 protein	20719421
D002117	Calcitriol	Calcitriol results in increased expression of TIMP2 mRNA	16002434
C081643	candesartan	candesartan results in decreased expression of TIMP2 mRNA	19047581
D002211	Capsaicin	Capsaicin results in increased expression of TIMP2 protein	22150557
D002211	Capsaicin	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
D002211	Capsaicin	Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
D002211	Capsaicin	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
D002220	Carbamazepine	Carbamazepine affects the expression of TIMP2 mRNA	25979313
C006698	carbendazim	carbendazim results in increased expression of TIMP2 mRNA	25530041
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TIMP2 mRNA	17484886
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of TIMP2 mRNA	25827057
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TIMP2 mRNA	14999682; 15056808; 16508911; 16539848; 18263696; 20438794; 25827057;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TIMP2 protein	16539848; 29987408;
D002251	Carbon Tetrachloride	IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	16539848
D002251	Carbon Tetrachloride	IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 protein]	16539848
D002251	Carbon Tetrachloride	OSMR protein affects the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	14999682
D002251	Carbon Tetrachloride	[PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of TIMP2 protein	29987408
D002251	Carbon Tetrachloride	POMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	16508911
D002251	Carbon Tetrachloride	2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	16033810
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TIMP2 mRNA	15963342
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with Celecoxib] results in increased expression of TIMP2 mRNA	16420518
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TIMP2 mRNA	15860571; 16033810; 17631135; 25150141;
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TIMP2 protein	17094476; 17156884; 17631135; 25150141;
D002251	Carbon Tetrachloride	obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	15860571
C054133	casticin	casticin results in increased expression of TIMP2 mRNA	28444820
D000068579	Celecoxib	[Carbon Tetrachloride co-treated with Celecoxib] results in increased expression of TIMP2 mRNA	16420518
C007020	chlorophyllin	chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 mRNA]	22485181
C007020	chlorophyllin	chlorophyllin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 protein]	22485181
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of TIMP2 mRNA	27344345
D002793	Cholic Acids	[Cyclosporine co-treated with Cholic Acids] affects the expression of TIMP2 mRNA	27344345
D002794	Choline	Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA]	18513333
D002794	Choline	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA	18513333
D002794	Choline	[Dietary Fats co-treated with Choline deficiency] results in increased expression of TIMP2 protein	29246445
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TIMP2 mRNA	20938992
D002794	Choline	PANX1 gene mutant form inhibits the reaction [[Dietary Fats co-treated with Choline deficiency] results in increased expression of TIMP2 protein]	29246445
D002945	Cisplatin	Cisplatin results in increased expression of TIMP2 mRNA	21151649
D002945	Cisplatin	Cisplatin results in decreased expression of TIMP2 mRNA	22023808
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TIMP2 mRNA	17553155; 19320972;
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TIMP2 protein	17553155
D005576	Colforsin	Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein]	21832167
D005576	Colforsin	Colforsin results in increased expression of TIMP2 protein	21832167
D003300	Copper	Copper results in decreased expression of TIMP2 mRNA	24403277
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TIMP2 mRNA	15467011
D003300	Copper	[glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP2 protein	11045606
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TIMP2 mRNA	19549813
C423222	cotylenin A	cotylenin A results in increased expression of TIMP2 mRNA	16129123
D003375	Coumestrol	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TIMP2 mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of TIMP2 mRNA	19167446
D003474	Curcumin	Curcumin results in decreased expression of TIMP2 protein	17996675
D003474	Curcumin	Curcumin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
C009160	cyclonite	cyclonite results in increased expression of TIMP2 mRNA	25559034
D016572	Cyclosporine	[Cyclosporine co-treated with Cholic Acids] affects the expression of TIMP2 mRNA	27344345
D016572	Cyclosporine	Cyclosporine results in decreased expression of TIMP2 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of TIMP2 mRNA	20106945; 21632981; 25562108;
D003545	Cysteine	Cysteine inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15158331
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of TIMP2 mRNA	23640034
C107676	deguelin	deguelin results in increased expression of TIMP2 protein	25322282
C050229	demethoxycurcumin	demethoxycurcumin results in decreased expression of TIMP2 protein	18495463
D003907	Dexamethasone	Dexamethasone results in increased expression of TIMP2 mRNA	21247626
D003907	Dexamethasone	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA]	16054899
D003907	Dexamethasone	Dexamethasone results in decreased expression of TIMP2 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of TIMP2 mRNA]	20032058
D016264	Dextran Sulfate	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TIMP2 mRNA	29950665
C028009	diallyl disulfide	diallyl disulfide results in increased expression of TIMP2 mRNA	20600798
C042577	diallyl trisulfide	diallyl trisulfide results in increased expression of TIMP2 mRNA	24084732
C042577	diallyl trisulfide	diallyl trisulfide results in increased expression of TIMP2 protein	24084732
D003976	Diazinon	Diazinon results in increased methylation of TIMP2 gene	22964155
C020735	dibutyldichlorotin	dibutyldichlorotin results in increased expression of TIMP2 mRNA	30611790
C020735	dibutyldichlorotin	dibutyldichlorotin results in increased expression of TIMP2 protein	30611790
C020735	dibutyldichlorotin	saikosaponin inhibits the reaction [dibutyldichlorotin results in increased expression of TIMP2 mRNA]	30611790
C020735	dibutyldichlorotin	saikosaponin inhibits the reaction [dibutyldichlorotin results in increased expression of TIMP2 protein]	30611790
D004041	Dietary Fats	[Dietary Fats co-treated with Choline deficiency] results in increased expression of TIMP2 protein	29246445
D004041	Dietary Fats	Dietary Fats results in increased expression of TIMP2 mRNA	18296743
D004041	Dietary Fats	PANX1 gene mutant form inhibits the reaction [[Dietary Fats co-treated with Choline deficiency] results in increased expression of TIMP2 protein]	29246445
D004041	Dietary Fats	[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in increased expression of TIMP2 mRNA	19891982
D004051	Diethylhexyl Phthalate	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA]	19956873
D004051	Diethylhexyl Phthalate	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein]	19956873
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA	19956873
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of TIMP2 protein	19956873
D004051	Diethylhexyl Phthalate	Fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA]	19956873
D004051	Diethylhexyl Phthalate	Fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein]	19956873
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TIMP2 mRNA	28943392
D004052	Diethylnitrosamine	[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 mRNA	12015029
D004052	Diethylnitrosamine	[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 protein	12015029
C012125	diisononyl phthalate	diisononyl phthalate affects the expression of TIMP2 mRNA	31154059
D004128	Dimethylnitrosamine	Dimethylnitrosamine affects the expression of TIMP2 mRNA	16042886
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased activity of TIMP2 protein	15161499
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of TIMP2 mRNA	17036385; 18371158; 25380136;
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of TIMP2 protein	16965748; 17348192;
D004128	Dimethylnitrosamine	Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 mRNA]	17036385; 18371158;
D004128	Dimethylnitrosamine	Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 protein]	16965748
D004128	Dimethylnitrosamine	Plant Preparations inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 protein]	17348192
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	11682029
D015237	Dinoprost	Dinoprost results in increased expression of TIMP2 mRNA	21247626
D004237	Diuron	Diuron results in decreased expression of TIMP2 mRNA	21551480; 25152437;
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP2 mRNA	27188386
D004317	Doxorubicin	Doxorubicin results in decreased expression of TIMP2 mRNA	29803840
D004317	Doxorubicin	Doxorubicin results in decreased expression of TIMP2 mRNA	15033991
D004317	Doxorubicin	Doxorubicin results in increased expression of TIMP2 mRNA	22016648
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal results in increased expression of TIMP2 mRNA	29148169
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 mRNA]	17036385; 18371158;
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 protein]	16965748
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal results in decreased expression of TIMP2 protein	17526172
D004610	Ellagic Acid	Ellagic Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TIMP2 protein]	22485181
D004726	Endosulfan	Endosulfan results in decreased expression of TIMP2 mRNA	29391264
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of TIMP2 mRNA	12655031
D004958	Estradiol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]	19956873
D004958	Estradiol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]	19956873
D004958	Estradiol	Estradiol results in decreased expression of TIMP2 mRNA	19167446; 19956873;
D004958	Estradiol	Estradiol results in decreased expression of TIMP2 protein	19956873
D004958	Estradiol	Fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]	19956873
D004958	Estradiol	Fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]	19956873
D000431	Ethanol	Ethanol affects the splicing of TIMP2 mRNA	30319688
D000431	Ethanol	betulinic acid inhibits the reaction [Ethanol results in increased expression of TIMP2 protein]	21172400
D000431	Ethanol	betulin inhibits the reaction [Ethanol results in increased expression of TIMP2 protein]	21172400
D000431	Ethanol	Ethanol results in increased expression of TIMP2 protein	12524413; 21172400;
D000431	Ethanol	Ethanol results in increased expression of TIMP2 mRNA	28069986
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TIMP2 mRNA	23129252
D005054	Eugenol	Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA]	20434464
D005054	Eugenol	Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein]	20434464
C093323	farnesylthiosalicylic acid	farnesylthiosalicylic acid results in increased expression of TIMP2 mRNA	15288472
D011345	Fenofibrate	Fenofibrate inhibits the reaction [Zoledronic Acid results in increased expression of TIMP2 mRNA]	28871336
D017313	Fenretinide	Fenretinide results in decreased expression of TIMP2 mRNA	28973697
C017690	fenvalerate	fenvalerate affects the expression of TIMP2 mRNA	20003521
C000499	ferric oxide	ferric oxide results in increased expression of TIMP2 protein	24885771
C093230	fexofenadine	fexofenadine inhibits the reaction [TNF protein results in increased expression of TIMP2 protein]	15663564
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TIMP2 mRNA	20938992
D005620	Freund's Adjuvant	[Urethane co-treated with Freund's Adjuvant] results in increased expression of TIMP2 mRNA	12400877
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA]	19956873
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein]	19956873
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA]	19956873
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein]	19956873
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]	19956873
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]	19956873
C039281	furan	furan results in increased expression of TIMP2 mRNA	27387713
D005665	Furosemide	Furosemide affects the expression of TIMP2 mRNA	16526316
D005707	Gallic Acid	Gallic Acid inhibits the reaction [ALB modified form results in increased expression of TIMP2 mRNA]	24309158
D019833	Genistein	Genistein results in decreased expression of TIMP2 mRNA	15754008
D005944	Glucosamine	Glucosamine affects the expression of TIMP2 mRNA	17109745
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in decreased expression of TIMP2 mRNA]	17109745
D005947	Glucose	[Glucose co-treated with Air Pollutants] results in decreased expression of TIMP2 mRNA	26179980
D005947	Glucose	[Glucose co-treated with Particulate Matter] results in decreased expression of TIMP2 mRNA	26179980
D005947	Glucose	Glucose results in increased expression of TIMP2 protein	21367880
D005947	Glucose	isoangustone A inhibits the reaction [Glucose results in increased expression of TIMP2 protein]	21367880
C424943	glutamyl-Se-methylselenocysteine	glutamyl-Se-methylselenocysteine results in decreased expression of TIMP2 mRNA	11306469
C071834	glycidamide	glycidamide results in decreased expression of TIMP2 mRNA	17822822
C020905	glycyl-histidyl-lysine	[glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP2 protein	11045606
C010176	halofuginone	halofuginone inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	11172339; 12175628; 14739098;
C010176	halofuginone	halofuginone results in increased expression of TIMP2 mRNA	17180598
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of TIMP2 mRNA	15159207
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of TIMP2 mRNA	17183730
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of TIMP2 mRNA	20044591
C031927	hydroquinone	[MMP14 protein co-treated with TIMP2 protein] inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein]	18055817
C031927	hydroquinone	[TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein]	18055817
C031927	hydroquinone	[TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]	18055817
C031927	hydroquinone	[TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein]	18055817
C031927	hydroquinone	TIMP2 protein inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein]	18055817
C031927	hydroquinone	TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein]	18055817
C031927	hydroquinone	TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]	18055817
C031927	hydroquinone	TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein]	18055817
D019469	Indinavir	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA	16931933
D007213	Indomethacin	Curcumin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
D007213	Indomethacin	Indomethacin results in increased expression of TIMP2 protein	16934674
D007213	Indomethacin	Melatonin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
D007213	Indomethacin	Omeprazole inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TIMP2 mRNA	25613284
D019266	Iron, Dietary	Iron, Dietary affects the reaction [Thioacetamide affects the expression of TIMP2 mRNA]	18032466
C551631	isoangustone A	isoangustone A inhibits the reaction [Glucose results in increased expression of TIMP2 protein]	21367880
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TIMP2 mRNA	25961927
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of TIMP2 mRNA	26752646
C005134	juglone	juglone results in increased expression of TIMP2 mRNA	29992683
D007657	Ketone Bodies	Ketone Bodies results in increased expression of TIMP2 mRNA	15469884
D019344	Lactic Acid	Lactic Acid results in decreased expression of TIMP2 mRNA	30851411
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA	16931933
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA	16931933
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine] results in increased expression of TIMP2 mRNA	16931933
D007854	Lead	Lead affects the expression of TIMP2 mRNA	28903495
D019808	Losartan	Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]	20137537
D019808	Losartan	Losartan results in decreased expression of TIMP2 mRNA	20137537
D019808	Losartan	Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]	20137537
D008550	Melatonin	Melatonin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of TIMP2 mRNA	20353558
D019804	Mesalamine	Mesalamine results in increased expression of TIMP2 mRNA	10743803
D008694	Methamphetamine	Methamphetamine results in decreased expression of TIMP2 mRNA	29802913
D008694	Methamphetamine	Methamphetamine results in increased activity of TIMP2 protein	18198472
D008694	Methamphetamine	TIMP2 protein results in decreased susceptibility to Methamphetamine	18198472
D008701	Methapyrilene	Methapyrilene results in increased methylation of TIMP2 intron	30157460
D008715	Methionine	Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA]	18513333
D008715	Methionine	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA	18513333
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TIMP2 mRNA	20938992
D008715	Methionine	Methionine inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15158331
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 mRNA	12015029
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 protein	12015029
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TIMP2 mRNA	23179753; 28001369;
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of TIMP2 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of TIMP2 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TIMP2 mRNA	19840844
D008769	Methylnitronitrosoguanidine	Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA]	20434464
D008769	Methylnitronitrosoguanidine	Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein]	20434464
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA	20434464
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein	20434464
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of TIMP2 mRNA	29191790
D008790	Metoprolol	Metoprolol inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]	15326086
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 mRNA	21832167
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein	21832167
C016599	mono-(2-ethylhexyl)phthalate	Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein]	21832167
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of TIMP2 mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of TIMP2 mRNA	25554681
D009288	Naproxen	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
D009288	Naproxen	Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
C433446	N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine	N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA]	22841774
C029938	nickel sulfate	nickel sulfate results in increased expression of TIMP2 mRNA	15020194
D009569	Nitric Oxide	Nitric Oxide results in decreased expression of TIMP2 mRNA	18796497
D009569	Nitric Oxide	Nitric Oxide results in decreased expression of TIMP2 protein	18796497
C007350	nitrofen	nitrofen results in decreased expression of TIMP2 mRNA	20638522
C025256	nonylphenol	nonylphenol results in decreased expression of TIMP2 mRNA	22982499
C069741	norcantharidin	norcantharidin results in increased expression of TIMP2 mRNA	16681930
C069741	norcantharidin	norcantharidin results in increased expression of TIMP2 protein	16681930
D009638	Norepinephrine	Metoprolol inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]	15326086
D009638	Norepinephrine	Norepinephrine results in increased expression of TIMP2 mRNA	14577597; 15326086;
D009638	Norepinephrine	Prazosin inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]	15326086
C464660	obeticholic acid	obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]	15860571
C025589	ochratoxin A	ochratoxin A results in increased acetylation of TIMP2 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of TIMP2 promoter] which results in increased expression of TIMP2 mRNA	29098329; 29098329;
C025589	ochratoxin A	ochratoxin A results in increased expression of TIMP2 mRNA	29098329
C025589	ochratoxin A	[NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased expression of TIMP2 mRNA	28710020
C025589	ochratoxin A	ochratoxin A results in increased expression of TIMP2 mRNA	14994279
D019319	Okadaic Acid	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of TIMP2 mRNA	19840844
D000069463	Olive Oil	Olive Oil promotes the reaction [Streptozocin results in increased activity of TIMP2 protein]	25246140
D009853	Omeprazole	Omeprazole inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]	16934674
D009930	Organic Chemicals	Organic Chemicals results in increased expression of TIMP2 mRNA	20526952
D000077150	Oxaliplatin	[Oxaliplatin co-treated with Topotecan] results in increased expression of TIMP2 mRNA	25729387
D000077150	Oxaliplatin	Oxaliplatin results in increased expression of TIMP2 mRNA	25729387
D016627	Oxidopamine	Oxidopamine results in decreased expression of TIMP2 mRNA	19883732
D016627	Oxidopamine	Oxidopamine results in decreased expression of TIMP2 protein	19883732
D016627	Oxidopamine	TIMP2 protein results in decreased susceptibility to Oxidopamine	19883732
D010100	Oxygen	Oxygen deficiency results in increased expression of TIMP2 mRNA	16980344
D010126	Ozone	Ozone results in increased expression of TIMP2 mRNA	20980218
D010269	Paraquat	Paraquat results in decreased expression of TIMP2 mRNA	17215068
D010269	Paraquat	Paraquat results in decreased expression of TIMP2 protein	26988026
D010269	Paraquat	Ambroxol affects the reaction [Paraquat results in increased expression of TIMP2 mRNA]	21921364
D010269	Paraquat	Paraquat affects the expression of TIMP2 mRNA	16854511
D052638	Particulate Matter	[Glucose co-treated with Particulate Matter] results in decreased expression of TIMP2 mRNA	26179980
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of TIMP2 mRNA	18593933
C074968	pentaacetyl geniposide	pentaacetyl geniposide results in increased expression of TIMP2 mRNA	19464279
D010634	Phenobarbital	Phenobarbital affects the expression of TIMP2 mRNA	23091169
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TIMP2 mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of TIMP2 mRNA	26272509
D010862	Pilocarpine	Pilocarpine results in increased expression of TIMP2 mRNA	14656328
D010936	Plant Extracts	Plant Extracts results in decreased expression of TIMP2 mRNA	22144737
D010936	Plant Extracts	Plant Extracts results in increased expression of TIMP2 mRNA	23232078
D028321	Plant Preparations	Plant Preparations inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP2 protein]	17348192
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of TIMP2 mRNA	25716161
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of TIMP2 protein	23718831
D017035	Pravastatin	Pravastatin results in decreased expression of TIMP2 mRNA	16935385
D011224	Prazosin	Prazosin inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]	15326086
D011374	Progesterone	[Progesterone co-treated with Triclosan] results in decreased expression of TIMP2 mRNA	26604029
D011372	Progestins	Progestins results in decreased expression of TIMP2 mRNA	19609016
C005556	propionaldehyde	propionaldehyde results in increased expression of TIMP2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TIMP2 mRNA	24780913
C526689	punarnavine	punarnavine results in increased expression of TIMP2 protein	24060680
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]	27060453
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	15078482
D011794	Quercetin	Quercetin results in increased expression of TIMP2 mRNA	15309432; 21632981;
D011794	Quercetin	Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 mRNA]	21294050
D011794	Quercetin	Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TIMP2 protein]	21294050
D000077185	Resveratrol	Resveratrol results in decreased expression of TIMP2 mRNA	25394648
D000077154	Rosiglitazone	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA	16054899
D000077154	Rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA]	16054899
D012402	Rotenone	Rotenone results in increased expression of TIMP2 mRNA	22016648
D012435	S-Adenosylhomocysteine	S-Adenosylhomocysteine results in decreased expression of TIMP2 protein	19770485
C025759	saikosaponin	saikosaponin inhibits the reaction [dibutyldichlorotin results in increased expression of TIMP2 mRNA]	30611790
C025759	saikosaponin	saikosaponin inhibits the reaction [dibutyldichlorotin results in increased expression of TIMP2 protein]	30611790
D012503	Saponins	Saponins results in increased expression of TIMP2 mRNA	29148169
D019258	Saquinavir	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA	16931933
C093642	SB 203580	SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]	27060453
C410733	scriptaid	scriptaid affects the expression of TIMP2 mRNA	18813790
D012643	Selenium	Selenium inhibits the reaction [T-2 Toxin results in decreased expression of TIMP2 protein]	21144892
D012643	Selenium	Selenium results in decreased expression of TIMP2 mRNA	17390030
D012715	Sesame Oil	Sesame Oil results in increased expression of TIMP2 mRNA	29191790
D019821	Simvastatin	Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]	20137537
D019821	Simvastatin	Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]	20137537
D019821	Simvastatin	Simvastatin results in decreased expression of TIMP2 mRNA	20137537
C012037	solasodine	solasodine results in increased expression of TIMP2 mRNA	28283413
D012999	Soman	Soman results in increased expression of TIMP2 mRNA	19281266
D013311	Streptozocin	benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]	16732983; 20821936;
D013311	Streptozocin	benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein]	16732983; 20821936;
D013311	Streptozocin	Olive Oil promotes the reaction [Streptozocin results in increased activity of TIMP2 protein]	25246140
D013311	Streptozocin	Streptozocin results in increased activity of TIMP2 protein	25246140
D013311	Streptozocin	Streptozocin results in increased expression of TIMP2 mRNA	16732983; 20821936;
D013311	Streptozocin	Streptozocin results in increased expression of TIMP2 protein	16732983; 20821936;
D013427	Sulfapyridine	Sulfapyridine results in increased expression of TIMP2 mRNA	10743803
D012460	Sulfasalazine	Sulfasalazine results in increased expression of TIMP2 mRNA	22016648
C016766	sulforafan	sulforafan results in increased expression of TIMP2 mRNA	26833863
D018170	Sumatriptan	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
D018170	Sumatriptan	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]	22150557
D000077210	Sunitinib	Sunitinib results in increased expression of TIMP2 mRNA	31533062
C446685	systhane	systhane results in increased expression of TIMP2 mRNA	16643972
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of TIMP2 mRNA	31299295
D013605	T-2 Toxin	Selenium inhibits the reaction [T-2 Toxin results in decreased expression of TIMP2 protein]	21144892
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of TIMP2 protein	21144892
D013605	T-2 Toxin	T-2 Toxin affects the expression of TIMP2 mRNA	21112371
C087114	tebuconazole	tebuconazole results in increased expression of TIMP2 mRNA	26852204
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of TIMP2 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TIMP2 mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TIMP2 mRNA	19684285; 20106945; 21632981;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TIMP2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TIMP2 mRNA	15667827; 17586704;
C117155	tetracycline CMT-3	tetracycline CMT-3 results in decreased secretion of TIMP2 protein	11857423
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of TIMP2 protein	19969058
D013755	Tetradecanoylphorbol Acetate	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TIMP2 mRNA	19840844
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TIMP2 mRNA	25613284
D013792	Thalidomide	Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15464241
D013853	Thioacetamide	IL10 protein inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	16126171
D013853	Thioacetamide	Thioacetamide results in increased expression of TIMP2 mRNA	16126171
D013853	Thioacetamide	1,3-dimethylthiourea inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	11682029
D013853	Thioacetamide	Cysteine inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15158331
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TIMP2 mRNA	28943392
D013853	Thioacetamide	Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	11682029
D013853	Thioacetamide	halofuginone inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	11172339; 12175628; 14739098;
D013853	Thioacetamide	Iron, Dietary affects the reaction [Thioacetamide affects the expression of TIMP2 mRNA]	18032466
D013853	Thioacetamide	Methionine inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15158331
D013853	Thioacetamide	pyrrolidine dithiocarbamic acid inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]	15078482
D013853	Thioacetamide	Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]	15464241
D013853	Thioacetamide	Thioacetamide results in increased expression of TIMP2 mRNA	15158331; 15464241;
D013853	Thioacetamide	Thioacetamide results in increased expression of TIMP2 protein	11172339; 11682029; 12175628; 14739098; 15078482;
C003466	thymoquinone	pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]	27060453
C003466	thymoquinone	SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein]	27060453
C003466	thymoquinone	thymoquinone results in increased expression of TIMP2 protein	27060453
C009495	titanium dioxide	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TIMP2 mRNA	29950665
C009495	titanium dioxide	titanium dioxide results in decreased expression of TIMP2 mRNA	23557971; 27760801;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of TIMP2 mRNA	27404394; 27865774;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of TIMP2 protein	30291989
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TIMP2 mRNA	29505817; 30610935;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TIMP2 mRNA	29501877
D019772	Topotecan	[Oxaliplatin co-treated with Topotecan] results in increased expression of TIMP2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of TIMP2 mRNA	25729387
D014118	Toxins, Biological	Toxins, Biological affects the expression of TIMP2 mRNA	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of TIMP2 mRNA	24374174
D014212	Tretinoin	Tretinoin results in increased expression of TIMP2 mRNA	16129123
D014212	Tretinoin	Tretinoin results in increased expression of TIMP2 mRNA	16788091
D014260	Triclosan	[Progesterone co-treated with Triclosan] results in decreased expression of TIMP2 mRNA	26604029
D014260	Triclosan	Triclosan results in decreased expression of TIMP2 mRNA	26604029
D014284	Triiodothyronine	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of TIMP2 mRNA]	19228888
D014284	Triiodothyronine	Triiodothyronine results in increased expression of TIMP2 mRNA	19228888
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of TIMP2 mRNA	29024780
D000077288	Troglitazone	Troglitazone results in increased expression of TIMP2 mRNA	28973697
C113580	U 0126	U 0126 inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA]	22841774
D014520	Urethane	Urethane results in increased expression of TIMP2 mRNA	28818685
D014520	Urethane	[Urethane co-treated with Freund's Adjuvant] results in increased expression of TIMP2 mRNA	12400877
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of TIMP2 mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of TIMP2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of TIMP2 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of TIMP2 mRNA	23179753; 24935251; 27188386; 28001369;
D014635	Valproic Acid	Valproic Acid results in increased methylation of TIMP2 gene	29154799
D001335	Vehicle Emissions	[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of TIMP2 mRNA	19150882
D001335	Vehicle Emissions	[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of TIMP2 protein	19150882
D001335	Vehicle Emissions	[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in increased expression of TIMP2 mRNA	19891982
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of TIMP2 mRNA	17065432; 20197249;
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of TIMP2 mRNA	20980218
C573672	VI-14 flavonoid	VI-14 flavonoid results in increased expression of TIMP2 protein	22538171
C025643	vinclozolin	vinclozolin affects the expression of TIMP2 mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in increased expression of TIMP2 mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 affects the expression of TIMP2 mRNA	20044591
D000077337	Vorinostat	Vorinostat results in increased expression of TIMP2 protein	19509267
D014874	Water Pollutants, Chemical	Water Pollutants, Chemical results in increased expression of TIMP2 mRNA	20526952
D000077191	Wortmannin	Wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA]	22841774
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA	16931933
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA	16931933
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine] results in increased expression of TIMP2 mRNA	16931933
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of TIMP2 mRNA	18593933
D000077211	Zoledronic Acid	Zoledronic Acid results in increased expression of TIMP2 mRNA	28871336
D000077211	Zoledronic Acid	Zoledronic Acid results in increased expression of TIMP2 protein	28871336
D000077211	Zoledronic Acid	Fenofibrate inhibits the reaction [Zoledronic Acid results in increased expression of TIMP2 mRNA]	28871336
D000077211	Zoledronic Acid	SLC27A2 gene mutant form inhibits the reaction [Zoledronic Acid results in increased expression of TIMP2 mRNA]	28871336

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0903	Direct protein sequencing
KW-1015	Disulfide bond
KW-0479	Metal-binding
KW-0481	Metalloenzyme inhibitor
KW-0483	Metalloprotease inhibitor
KW-0646	Protease inhibitor
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal
KW-0862	Zinc

Interpro

InterPro ID	InterPro Term
IPR001134	Netrin_domain
IPR001820	TIMP
IPR008993	TIMP-like_OB-fold
IPR015613	TIMP2
IPR027465	TIMP_C
IPR030490	TIMP_CS

PROSITE

PROSITE ID	PROSITE Term
PS50189	NTR
PS00288	TIMP

Pfam

Pfam ID	Pfam Term
PF00965	TIMP