| Tag | Content |
|---|---|
| Uniprot ID | P16035; Q16121; Q93006; Q9UDF7; |
| Entrez ID | 7077 |
| Genbank protein ID | AAH52605.1; AAD14025.1; AAB19474.1; CAA38400.1; AAA59581.1; AAH71586.1; AAC50729.1; AAA61186.1; |
| Genbank nucleotide ID | NM_003255.4 |
| Ensembl protein ID | ENSP00000262768 |
| Ensembl nucleotide ID | ENSG00000035862 |
| Gene name | Metalloproteinase inhibitor 2 |
| Gene symbol | TIMP2 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21462296 |
| Functional description | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. |
| Sequence | MGAAARTLRL ALGLLLLATL LRPADACSCS PVHPQQAFCN ADVVIRAKAV SEKEVDSGND 60 IYGNPIKRIQ YEIKQIKMFK GPEKDIEFIY TAPSSAVCGV SLDVGGKKEY LIAGKAEGDG 120 KMHITLCDFI VPWDTLSTTQ KKSLNHRYQM GCECKITRCP MIPCYISSPD ECLWMDWVTE 180 KNINGHQAKF FACIKRSDGS CAWYRGAAPP KQEFLDIEDP |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.