| Tag | Content |
|---|---|
| Uniprot ID | P16056; Q62125; |
| Entrez ID | |
| Genbank protein ID | CAA68680.1; AAA40015.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Hepatocyte growth factor receptor |
| Gene symbol | Met |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 17881575 |
| Functional description | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity). May regulate cortical bone osteogenesis (PubMed:26637977). |
| Sequence | MKAPTVLAPG ILVLLLSLVQ RSHGECKEAL VKSEMNVNMK YQLPNFTAET PIQNVVLHGH 60 HIYLGATNYI YVLNDKDLQK VSEFKTGPVL EHPDCLPCRD CSSKANSSGG VWKDNINMAL 120 LVDTYYDDQL ISCGSVNRGT CQRHVLPPDN SADIQSEVHC MFSPEEESGQ CPDCVVSALG 180 AKVLLSEKDR FINFFVGNTI NSSYPPGYSL HSISVRRLKE TQDGFKFLTD QSYIDVLPEF 240 LDSYPIKYIH AFESNHFIYF LTVQKETLDA QTFHTRIIRF CSVDSGLHSY MEMPLECILT 300 EKRRKRSTRE EVFNILQAAY VSKPGANLAK QIGASPSDDI LFGVFAQSKP DSAEPVNRSA 360 VCAFPIKYVN DFFNKIVNKN NVRCLQHFYG PNHEHCFNRT LLRNSSGCEA RSDEYRTEFT 420 TALQRVDLFM GRLNQVLLTS ISTFIKGDLT IANLGTSEGR FMQVVLSRTA HLTPHVNFLL 480 DSHPVSPEVI VEHPSNQNGY TLVVTGKKIT KIPLNGLGCG HFQSCSQCLS APYFIQCGWC 540 HNQCVRFDEC PSGTWTQEIC LPAVYKVFPT SAPLEGGTVL TICGWDFGFR KNNKFDLRKT 600 KVLLGNESCT LTLSESTTNT LKCTVGPAMS EHFNVSVIIS NSRETTQYSA FSYVDPVITS 660 ISPRYGPQAG GTLLTLTGKY LNSGNSRHIS IGGKTCTLKS VSDSILECYT PAQTTSDEFP 720 VKLKIDLANR ETSSFSYRED PVVYEIHPTK SFISGGSTIT GIGKTLNSVS LPKLVIDVHE 780 VGVNYTVACQ HRSNSEIICC TTPSLKQLGL QLPLKTKAFF LLDGILSKHF DLTYVHNPVF 840 EPFEKPVMIS MGNENVVEIK GNNIDPEAVK GEVLKVGNQS CESLHWHSGA VLCTVPSDLL 900 KLNSELNIEW KQAVSSTVLG KVIVQPDQNF AGLIIGAVSI SVVVLLLSGL FLWMRKRKHK 960 DLGSELVRYD ARVHTPHLDR LVSARSVSPT TEMVSNESVD YRATFPEDQF PNSSQNGACR 1020 QVQYPLTDLS PILTSGDSDI SSPLLQNTVH IDLSALNPEL VQAVQHVVIG PSSLIVHFNE 1080 VIGRGHFGCV YHGTLLDNDG KKIHCAVKSL NRITDIEEVS QFLTEGIIMK DFSHPNVLSL 1140 LGICLRSEGS PLVVLPYMKH GDLRNFIRNE THNPTVKDLI GFGLQVAKGM KYLASKKFVH 1200 RDLAARNCML DEKFTVKVAD FGLARDMYDK EYYSVHNKTG AKLPVKWMAL ESLQTQKFTT 1260 KSDVWSFGVL LWELMTRGAP PYPDVNTFDI TIYLLQGRRL LQPEYCPDAL YEVMLKCWHP 1320 KAEMRPSFSE LVSRISSIFS TFIGEHYVHV NATYVNVKCV APYPSLLPSQ DNIDGEGNT 1379 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004672 | protein kinase activity | IDA |
| GO:0004713 | protein tyrosine kinase activity | ISO |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IBA |
| GO:0005008 | hepatocyte growth factor-activated receptor activity | ISO |
| GO:0005008 | hepatocyte growth factor-activated receptor activity | IDA |
| GO:0005008 | hepatocyte growth factor-activated receptor activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0008013 | beta-catenin binding | ISO |
| GO:0017154 | semaphorin receptor activity | IEA |
| GO:0019903 | protein phosphatase binding | ISO |
| GO:0042802 | identical protein binding | ISO |
| GO:0043274 | phospholipase binding | ISO |
| GO:0043548 | phosphatidylinositol 3-kinase binding | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0000187 | activation of MAPK activity | IPI |
| GO:0001764 | neuron migration | ISO |
| GO:0001886 | endothelial cell morphogenesis | ISO |
| GO:0001889 | liver development | IBA |
| GO:0001889 | liver development | IMP |
| GO:0001890 | placenta development | IMP |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA |
| GO:0007268 | chemical synaptic transmission | IMP |
| GO:0007275 | multicellular organism development | IBA |
| GO:0007420 | brain development | IMP |
| GO:0007517 | muscle organ development | IGI |
| GO:0007517 | muscle organ development | IMP |
| GO:0007519 | skeletal muscle tissue development | IMP |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0010629 | negative regulation of gene expression | IMP |
| GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | ISO |
| GO:0010801 | negative regulation of peptidyl-threonine phosphorylation | ISO |
| GO:0010828 | positive regulation of glucose transmembrane transport | IMP |
| GO:0010976 | positive regulation of neuron projection development | ISO |
| GO:0014812 | muscle cell migration | IMP |
| GO:0014902 | myotube differentiation | IMP |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA |
| GO:0030182 | neuron differentiation | IBA |
| GO:0030317 | flagellated sperm motility | ISO |
| GO:0030534 | adult behavior | IMP |
| GO:0031016 | pancreas development | IBA |
| GO:0031116 | positive regulation of microtubule polymerization | ISO |
| GO:0032675 | regulation of interleukin-6 production | IMP |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | ISO |
| GO:0033674 | positive regulation of kinase activity | IBA |
| GO:0035024 | negative regulation of Rho protein signal transduction | ISO |
| GO:0042593 | glucose homeostasis | IMP |
| GO:0045740 | positive regulation of DNA replication | ISO |
| GO:0045840 | positive regulation of mitotic nuclear division | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0046777 | protein autophosphorylation | ISO |
| GO:0046777 | protein autophosphorylation | IDA |
| GO:0048012 | hepatocyte growth factor receptor signaling pathway | IDA |
| GO:0048754 | branching morphogenesis of an epithelial tube | ISO |
| GO:0050775 | positive regulation of dendrite morphogenesis | ISO |
| GO:0050804 | modulation of chemical synaptic transmission | IMP |
| GO:0050918 | positive chemotaxis | ISO |
| GO:0050918 | positive chemotaxis | IMP |
| GO:0051450 | myoblast proliferation | IMP |
| GO:0051497 | negative regulation of stress fiber assembly | ISO |
| GO:0051897 | positive regulation of protein kinase B signaling | IBA |
| GO:0055013 | cardiac muscle cell development | IMP |
| GO:0060048 | cardiac muscle contraction | IMP |
| GO:0060079 | excitatory postsynaptic potential | IMP |
| GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling | IMP |
| GO:0061436 | establishment of skin barrier | ISO |
| GO:0070495 | negative regulation of thrombin-activated receptor signaling pathway | ISO |
| GO:0071526 | semaphorin-plexin signaling pathway | ISO |
| GO:0071526 | semaphorin-plexin signaling pathway | IMP |
| GO:0071635 | negative regulation of transforming growth factor beta production | IMP |
| GO:0072593 | reactive oxygen species metabolic process | IMP |
| GO:1900407 | regulation of cellular response to oxidative stress | IMP |
| GO:1900745 | positive regulation of p38MAPK cascade | IMP |
| GO:1901299 | negative regulation of hydrogen peroxide-mediated programmed cell death | ISO |
| GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity | ISO |
| GO:2001028 | positive regulation of endothelial cell chemotaxis | ISS |
| GO:2001028 | positive regulation of endothelial cell chemotaxis | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | ISO |
| GO:0005737 | cytoplasm | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0009925 | basal plasma membrane | ISO |
| GO:0009925 | basal plasma membrane | IBA |
| GO:0014069 | postsynaptic density | ISO |
| GO:0016020 | membrane | IDA |
| GO:0030425 | dendrite | ISO |
| GO:0036126 | sperm flagellum | ISO |
| GO:0043005 | neuron projection | ISO |
| GO:0043025 | neuronal cell body | ISO |
| GO:0043235 | receptor complex | IBA |
| GO:0045211 | postsynaptic membrane | ISO |
| GO:0060076 | excitatory synapse | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0656 | Proto-oncogene |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| KW-0832 | Ubl conjugation |
| InterPro ID | InterPro Term |
|---|---|
| IPR013783 | Ig-like_fold |
| IPR014756 | Ig_E-set |
| IPR002909 | IPT_dom |
| IPR011009 | Kinase-like_dom_sf |
| IPR031148 | Plexin |
| IPR002165 | Plexin_repeat |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR016201 | PSI |
| IPR001627 | Semap_dom |
| IPR036352 | Semap_dom_sf |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR016244 | Tyr_kinase_HGF/MSP_rcpt |
| IPR015943 | WD40/YVTN_repeat-like_dom_sf |