CleftGeneDB-Search

Gene: CDH2

Basic information

Tag	Content
Uniprot ID	P19022; A8MWK3; B0YIY6; Q14923; Q8N173;
Entrez ID	1000
Genbank protein ID	AAH36470.1; CAA81799.1; BAH13814.1; CAA40773.1; AAB22854.1; CAA38213.1; AAA03236.1; EAX01240.1; ACA05964.1;
Genbank nucleotide ID	NM_001308176.1; NM_001792.4;
Ensembl protein ID	ENSP00000269141; ENSP00000382312;
Ensembl nucleotide ID	ENSG00000170558
Gene name	Cadherin-2
Gene symbol	CDH2
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Manually collected
Reference	29524576
Functional description	Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Sequence	MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH EGQPLLNVKF 60 SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA KFLIYAQDKE TQEKWQVAVK 120 LSLKPTLTEE SVKESAEVEE IVFPRQFSKH SGHLQRQKRD WVIPPINLPE NSRGPFPQEL 180 VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV 240 DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 300 NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 360 GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV ANLTVTDKDQ PHTPAWNAVY 420 RISGGDPTGR FAIQTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 480 TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP 540 ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600 NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 660 FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 720 GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 780 EDQDYDLSQL QQPDTVEPDA IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 840 KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 900 YGGGDD 906

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Species	Evidence	Details
1:1 ortholog	CDH2		P19534	Bos taurus	Prediction	More>>
1:1 ortholog	CDH2	480169	A0A5F4CJ70	Canis lupus familiaris	Prediction	More>>
1:1 ortholog	CDH2		A0A452F6F0	Capra hircus	Prediction	More>>
1:1 ortholog	CDH2	1000	P19022	Homo sapiens	Publication	More>>
1:1 ortholog	Cdh2		D3YYT0	Mus musculus	Prediction	More>>
1:1 ortholog	CDH2		A0A2I3SSD4	Pan troglodytes	Prediction	More>>
1:1 ortholog	CDH2		F1SAM3	Sus scrofa	Prediction	More>>
1:1 ortholog	Cdh2		G3V803	Rattus norvegicus	Prediction	More>>
1:1 ortholog	cdh2		G1K2E7	Danio rerio	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
CDH2	rs539075T>G	Genotyping	29524576
CDH2	rs539075T>G	ARMS-PCR;	29524576

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs761151029	p.Arg3Gly	missense variant	-	NC_000018.10:g.28177016G>C	ExAC,TOPMed,gnomAD
rs1323181717	p.Arg3Gln	missense variant	-	NC_000018.10:g.28177015C>T	TOPMed
rs761151029	p.Arg3Trp	missense variant	-	NC_000018.10:g.28177016G>A	ExAC,TOPMed,gnomAD
rs1284853215	p.Ala5Val	missense variant	-	NC_000018.10:g.28177009G>A	TOPMed,gnomAD
rs1369360558	p.Leu8Val	missense variant	-	NC_000018.10:g.28177001G>C	TOPMed,gnomAD
rs1293733346	p.Leu8Pro	missense variant	-	NC_000018.10:g.28177000A>G	gnomAD
rs1403830213	p.Arg9Trp	missense variant	-	NC_000018.10:g.28176998G>A	TOPMed,gnomAD
rs1403830213	p.Arg9Gly	missense variant	-	NC_000018.10:g.28176998G>C	TOPMed,gnomAD
rs773400550	p.Thr10Asn	missense variant	-	NC_000018.10:g.28176994G>T	ExAC,TOPMed,gnomAD
rs879030779	p.Thr10Pro	missense variant	-	NC_000018.10:g.28176995T>G	TOPMed,gnomAD
rs773400550	p.Thr10Ile	missense variant	-	NC_000018.10:g.28176994G>A	ExAC,TOPMed,gnomAD
rs879030779	p.Thr10Ser	missense variant	-	NC_000018.10:g.28176995T>A	TOPMed,gnomAD
rs879030779	p.Thr10Ala	missense variant	-	NC_000018.10:g.28176995T>C	TOPMed,gnomAD
rs1363152842	p.Pro13Leu	missense variant	-	NC_000018.10:g.28176985G>A	TOPMed,gnomAD
rs1420154381	p.Pro13Ser	missense variant	-	NC_000018.10:g.28176986G>A	TOPMed,gnomAD
rs1434663670	p.Leu14Pro	missense variant	-	NC_000018.10:g.28176982A>G	gnomAD
rs1490213867	p.Ala16Val	missense variant	-	NC_000018.10:g.28176976G>A	TOPMed,gnomAD
rs1456038030	p.Ala16Thr	missense variant	-	NC_000018.10:g.28176977C>T	TOPMed
rs1219438806	p.Ala17Val	missense variant	-	NC_000018.10:g.28176973G>A	TOPMed,gnomAD
rs1214159271	p.Leu19Phe	missense variant	-	NC_000018.10:g.28176968G>A	gnomAD
rs1332308156	p.Gln20His	missense variant	-	NC_000018.10:g.28176963C>A	TOPMed
rs751608409	p.Ala21Glu	missense variant	-	NC_000018.10:g.28147783G>T	ExAC,TOPMed,gnomAD
rs17495042	p.Ala21Thr	missense variant	-	NC_000018.10:g.28147784C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs751608409	p.Ala21Val	missense variant	-	NC_000018.10:g.28147783G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ser22SerAlaTyrAsnTerAsn	stop gained	-	NC_000018.10:g.28147779_28147780insTTCTAATTGTAAGCACTT	NCI-TCGA
rs201041020	p.Val23Ala	missense variant	-	NC_000018.10:g.28147777A>G	TOPMed
rs755151089	p.Val23Leu	missense variant	-	NC_000018.10:g.28147778C>G	ExAC,gnomAD
rs146386375	p.Glu24Gln	missense variant	-	NC_000018.10:g.28147775C>G	ESP,ExAC,TOPMed,gnomAD
rs766647206	p.Ser26Phe	missense variant	-	NC_000018.10:g.28147768G>A	ExAC,gnomAD
COSM6083208	p.Gly27Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28147765C>A	NCI-TCGA Cosmic
rs1462592216	p.Gly27Ser	missense variant	-	NC_000018.10:g.28147766C>T	gnomAD
rs1372513645	p.Ile29Asn	missense variant	-	NC_000018.10:g.28147759A>T	gnomAD
rs200711868	p.Ala30Thr	missense variant	-	NC_000018.10:g.28147757C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Cys32Tyr	missense variant	-	NC_000018.10:g.28147750C>T	NCI-TCGA
NCI-TCGA novel	p.Lys33Asn	missense variant	-	NC_000018.10:g.28147746C>A	NCI-TCGA
COSM1388207	p.Lys33Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000018.10:g.28147748T>A	NCI-TCGA Cosmic
rs201462293	p.Lys33Glu	missense variant	-	NC_000018.10:g.28147748T>C	ESP,ExAC,TOPMed,gnomAD
rs774902934	p.Pro37Leu	missense variant	-	NC_000018.10:g.28147735G>A	ExAC,TOPMed,gnomAD
rs1274623800	p.Glu38Lys	missense variant	-	NC_000018.10:g.28147733C>T	TOPMed
NCI-TCGA novel	p.Asp39Asn	missense variant	-	NC_000018.10:g.28147730C>T	NCI-TCGA
rs879180473	p.Asp39Glu	missense variant	-	NC_000018.10:g.28147728A>T	TOPMed
rs769118218	p.Asp39Val	missense variant	-	NC_000018.10:g.28147729T>A	ExAC,TOPMed,gnomAD
rs769118218	p.Asp39Gly	missense variant	-	NC_000018.10:g.28147729T>C	ExAC,TOPMed,gnomAD
rs1197088956	p.Val40Ile	missense variant	-	NC_000018.10:g.28147727C>T	TOPMed
rs757055934	p.TyrSer41Ter	stop gained	-	NC_000018.10:g.28147722_28147723del	ExAC,gnomAD
rs1246347582	p.Val44Phe	missense variant	-	NC_000018.10:g.28147715C>A	gnomAD
rs774927665	p.Val44Ala	missense variant	-	NC_000018.10:g.28147714A>G	ExAC,TOPMed,gnomAD
rs780887307	p.Ser46Leu	missense variant	-	NC_000018.10:g.28147708G>A	ExAC,gnomAD
rs1026380265	p.His50Arg	missense variant	-	NC_000018.10:g.28147696T>C	TOPMed,gnomAD
rs150672295	p.His50Tyr	missense variant	-	NC_000018.10:g.28147697G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
COSM1172540	p.Glu51Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28147692T>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Gly52Ter	stop gained	-	NC_000018.10:g.28147691C>A	NCI-TCGA
COSM4071678	p.Gly52Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28147690C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Leu56Ile	missense variant	-	NC_000018.10:g.28147679G>T	NCI-TCGA
NCI-TCGA novel	p.Leu56Phe	missense variant	-	NC_000018.10:g.28147679G>A	NCI-TCGA
rs1459488007	p.Asn57Ser	missense variant	-	NC_000018.10:g.28147675T>C	gnomAD
COSM4071677	p.Lys59Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28013906T>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ser61Cys	missense variant	-	NC_000018.10:g.28013901T>A	NCI-TCGA
rs202205175	p.Asn64His	missense variant	-	NC_000018.10:g.28013892T>G	1000Genomes,ExAC,TOPMed,gnomAD
rs779271742	p.Asn64Ser	missense variant	-	NC_000018.10:g.28013891T>C	ExAC,gnomAD
rs1357817564	p.Gly65Glu	missense variant	-	NC_000018.10:g.28013888C>T	TOPMed
rs201274796	p.Lys66Glu	missense variant	-	NC_000018.10:g.28013886T>C	ExAC,gnomAD
rs766988186	p.Arg67Ile	missense variant	-	NC_000018.10:g.28013882C>A	ExAC,TOPMed,gnomAD
rs755723588	p.Val69Ile	missense variant	-	NC_000018.10:g.28013877C>T	ExAC,gnomAD
rs1372835307	p.Gln70Glu	missense variant	-	NC_000018.10:g.28013874G>C	TOPMed
COSM3422104	p.Glu72Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28013866C>A	NCI-TCGA Cosmic
COSM3796339	p.Glu72Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28013868C>G	NCI-TCGA Cosmic
rs1290280143	p.Glu72Lys	missense variant	-	NC_000018.10:g.28013868C>T	TOPMed
rs1431697220	p.Glu75Lys	missense variant	-	NC_000018.10:g.28013859C>T	TOPMed,gnomAD
rs767296927	p.Ala77Thr	missense variant	-	NC_000018.10:g.28013853C>T	ExAC,gnomAD
NCI-TCGA novel	p.Asp78Tyr	missense variant	-	NC_000018.10:g.28013850C>A	NCI-TCGA
rs763887861	p.Asp78Asn	missense variant	-	NC_000018.10:g.28013850C>T	ExAC,TOPMed,gnomAD
rs763887861	p.Asp78His	missense variant	-	NC_000018.10:g.28013850C>G	ExAC,TOPMed,gnomAD
rs1237757504	p.Val81Met	missense variant	-	NC_000018.10:g.28013841C>T	TOPMed
rs762655258	p.Asp82Glu	missense variant	-	NC_000018.10:g.28013836A>T	ExAC,gnomAD
rs376492579	p.Glu83Gly	missense variant	-	NC_000018.10:g.28013834T>C	ESP,ExAC,TOPMed,gnomAD
rs373421991	p.Asp84Gly	missense variant	-	NC_000018.10:g.28013831T>C	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gly85Asp	missense variant	-	NC_000018.10:g.28013828C>T	NCI-TCGA
COSM6148963	p.Gly85Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28013828C>A	NCI-TCGA Cosmic
rs773237462	p.Met86Thr	missense variant	-	NC_000018.10:g.28013825A>G	ExAC,gnomAD
rs778990479	p.Val90Leu	missense variant	-	NC_000018.10:g.28013814C>A	ExAC,TOPMed,gnomAD
rs778990479	p.Val90Met	missense variant	-	NC_000018.10:g.28013814C>T	ExAC,TOPMed,gnomAD
COSM987345	p.Arg91Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28013810C>A	NCI-TCGA Cosmic
rs188546474	p.Ser92Arg	missense variant	-	NC_000018.10:g.28013806G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs150017015	p.Ser92Gly	missense variant	-	NC_000018.10:g.28013808T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro94Ser	missense variant	-	NC_000018.10:g.28013802G>A	NCI-TCGA
rs756638795	p.Pro94Leu	missense variant	-	NC_000018.10:g.28013801G>A	ExAC,gnomAD
rs1354225874	p.Leu95Val	missense variant	-	NC_000018.10:g.28013799G>C	TOPMed
rs1361176600	p.Ser96Phe	missense variant	-	NC_000018.10:g.28013795G>A	gnomAD
rs113785794	p.His99Arg	missense variant	-	NC_000018.10:g.28013786T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs562222525	p.His99Tyr	missense variant	-	NC_000018.10:g.28013787G>A	ExAC,gnomAD
NCI-TCGA novel	p.Ala100Asp	missense variant	-	NC_000018.10:g.28013783G>T	NCI-TCGA
rs1404361272	p.Lys101Asn	missense variant	-	NC_000018.10:g.28013779C>A	TOPMed
COSM708202	p.Phe102Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28013777A>G	NCI-TCGA Cosmic
rs1274222569	p.Leu103Val	missense variant	-	NC_000018.10:g.28013775G>C	TOPMed
rs1177369468	p.Ile104Thr	missense variant	-	NC_000018.10:g.28013771A>G	gnomAD
rs1469377111	p.Ala106Thr	missense variant	-	NC_000018.10:g.28013766C>T	gnomAD
rs756870194	p.Gln107Glu	missense variant	-	NC_000018.10:g.28013763G>C	ExAC,gnomAD
rs751296292	p.Asp108Tyr	missense variant	-	NC_000018.10:g.28013760C>A	ExAC,gnomAD
rs1429699775	p.Lys109Arg	missense variant	-	NC_000018.10:g.28013756T>C	gnomAD
rs552668002	p.Glu110Gln	missense variant	-	NC_000018.10:g.28013754C>G	NCI-TCGA
COSM1388206	p.Glu110Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28013753T>G	NCI-TCGA Cosmic
rs552668002	p.Glu110Gln	missense variant	-	NC_000018.10:g.28013754C>G	ExAC,TOPMed,gnomAD
rs762857696	p.Thr111Asn	missense variant	-	NC_000018.10:g.28013750G>T	ExAC
NCI-TCGA novel	p.Gln112Pro	missense variant	-	NC_000018.10:g.28013747T>G	NCI-TCGA
rs368957587	p.Gln112Arg	missense variant	-	NC_000018.10:g.28013747T>C	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Trp115Leu	missense variant	-	NC_000018.10:g.28013738C>A	NCI-TCGA
rs17445840	p.Ala118Thr	missense variant	-	NC_000018.10:g.28013730C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs374765506	p.Leu121Phe	missense variant	-	NC_000018.10:g.28013719C>G	ExAC,gnomAD
rs749692083	p.Lys124Thr	missense variant	-	NC_000018.10:g.28013711T>G	ExAC,gnomAD
rs770426519	p.Thr126Ile	missense variant	-	NC_000018.10:g.28013705G>A	ExAC,gnomAD
rs971731737	p.Leu127Phe	missense variant	-	NC_000018.10:g.28013701T>G	TOPMed,gnomAD
rs1197514285	p.Leu127Ter	stop gained	-	NC_000018.10:g.28013702A>C	TOPMed
rs781533778	p.Leu127Val	missense variant	-	NC_000018.10:g.28013703A>C	ExAC,TOPMed,gnomAD
rs751016097	p.Thr128Pro	missense variant	-	NC_000018.10:g.28013700T>G	ExAC,TOPMed,gnomAD
rs199902980	p.Thr128Ile	missense variant	-	NC_000018.10:g.28013699G>A	ESP,ExAC,TOPMed,gnomAD
rs751016097	p.Thr128Ala	missense variant	-	NC_000018.10:g.28013700T>C	ExAC,TOPMed,gnomAD
rs751016097	p.Thr128Ser	missense variant	-	NC_000018.10:g.28013700T>A	ExAC,TOPMed,gnomAD
rs199902980	p.Thr128Ser	missense variant	-	NC_000018.10:g.28013699G>C	ESP,ExAC,TOPMed,gnomAD
rs963079228	p.Glu129Lys	missense variant	-	NC_000018.10:g.28013697C>T	TOPMed
rs963079228	p.Glu129Lys	missense variant	-	NC_000018.10:g.28013697C>T	NCI-TCGA Cosmic
rs202040611	p.Ser131Leu	missense variant	-	NC_000018.10:g.28013690G>A	ExAC,TOPMed,gnomAD
rs183606230	p.Ser131Pro	missense variant	-	NC_000018.10:g.28013691A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs759313084	p.Val132Met	missense variant	-	NC_000018.10:g.28013688C>T	ExAC,gnomAD
NCI-TCGA novel	p.Lys133Asn	missense variant	-	NC_000018.10:g.28013683C>A	NCI-TCGA
rs980711081	p.Lys133Arg	missense variant	-	NC_000018.10:g.28013684T>C	TOPMed,gnomAD
rs202032913	p.Glu134Val	missense variant	-	NC_000018.10:g.28011991T>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ser135Ter	stop gained	-	NC_000018.10:g.28011988G>T	NCI-TCGA
NCI-TCGA novel	p.Ala136Ser	missense variant	-	NC_000018.10:g.28011986C>A	NCI-TCGA
rs1396498254	p.Glu137Val	missense variant	-	NC_000018.10:g.28011982T>A	TOPMed
rs1248902182	p.Glu137Lys	missense variant	-	NC_000018.10:g.28011983C>T	gnomAD
rs1393606084	p.Val138Asp	missense variant	-	NC_000018.10:g.28011979A>T	TOPMed
rs1306883724	p.Val138Ile	missense variant	-	NC_000018.10:g.28011980C>T	TOPMed
rs1393676210	p.Glu139Lys	missense variant	-	NC_000018.10:g.28011977C>T	TOPMed
COSM2808403	p.Glu140Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000018.10:g.28011974C>A	NCI-TCGA Cosmic
rs1315829375	p.Val142Ala	missense variant	-	NC_000018.10:g.28011967A>G	gnomAD
NCI-TCGA novel	p.Arg145Lys	missense variant	-	NC_000018.10:g.28011958C>T	NCI-TCGA
rs755964535	p.Arg145Gly	missense variant	-	NC_000018.10:g.28011959T>C	ExAC,gnomAD
rs1352509680	p.Phe147Ser	missense variant	-	NC_000018.10:g.28011952A>G	gnomAD
rs764209293	p.Ser148Asn	missense variant	-	NC_000018.10:g.28011949C>T	ExAC,gnomAD
NCI-TCGA novel	p.Lys149Asn	missense variant	-	NC_000018.10:g.28011945C>A	NCI-TCGA
rs554270276	p.Lys149Thr	missense variant	-	NC_000018.10:g.28011946T>G	1000Genomes,ExAC,gnomAD
rs765538223	p.Ser151Arg	missense variant	-	NC_000018.10:g.28011941T>G	ExAC,TOPMed,gnomAD
rs765538223	p.Ser151Gly	missense variant	-	NC_000018.10:g.28011941T>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.His153Tyr	missense variant	-	NC_000018.10:g.28011935G>A	NCI-TCGA
COSM1388205	p.Arg156Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28011925C>A	NCI-TCGA Cosmic
COSM4941798	p.Arg159Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28011917T>C	NCI-TCGA Cosmic
rs1395522862	p.Trp161Ter	stop gained	-	NC_000018.10:g.28011910C>T	gnomAD
rs79870170	p.Pro169Leu	missense variant	-	NC_000018.10:g.28011886G>A	gnomAD
rs79870170	p.Pro169Gln	missense variant	-	NC_000018.10:g.28011886G>T	gnomAD
NCI-TCGA novel	p.Ser172Pro	missense variant	-	NC_000018.10:g.28011878A>G	NCI-TCGA
rs773758651	p.Ser172Phe	missense variant	-	NC_000018.10:g.28011877G>A	ExAC,gnomAD
NCI-TCGA novel	p.Gly174Val	missense variant	-	NC_000018.10:g.28011871C>A	NCI-TCGA
rs574618454	p.Pro175Ser	missense variant	-	NC_000018.10:g.28011869G>A	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Pro177His	missense variant	-	NC_000018.10:g.28011862G>T	NCI-TCGA
COSM473718	p.Gln178Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000018.10:g.28011860G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Val181Ile	missense variant	-	NC_000018.10:g.28011851C>T	NCI-TCGA
NCI-TCGA novel	p.Arg182Ser	missense variant	-	NC_000018.10:g.28011846C>A	NCI-TCGA
COSM3821288	p.Arg187Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28009859C>G	NCI-TCGA Cosmic
rs1188836783	p.Asp188Glu	missense variant	-	NC_000018.10:g.28009855A>C	gnomAD
rs1342149311	p.Lys189Glu	missense variant	-	NC_000018.10:g.28009854T>C	gnomAD
rs201863564	p.Leu191Ile	missense variant	-	NC_000018.10:g.28009848G>T	ExAC,gnomAD
rs773733261	p.Arg194Gln	missense variant	-	NC_000018.10:g.28009838C>T	ExAC,TOPMed,gnomAD
rs1228174771	p.Arg194Trp	missense variant	-	NC_000018.10:g.28009839G>A	TOPMed,gnomAD
rs1041970	p.Ser196Thr	missense variant	-	NC_000018.10:g.28009832C>G	UniProt,dbSNP
VAR_028256	p.Ser196Thr	missense variant	-	NC_000018.10:g.28009832C>G	UniProt
rs1041970	p.Ser196Thr	missense variant	-	NC_000018.10:g.28009832C>G	-
COSM6083212	p.Gly199Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28009823C>A	NCI-TCGA Cosmic
COSM708205	p.Gly201Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28009817C>A	NCI-TCGA Cosmic
COSM708204	p.Gly201Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28009817C>G	NCI-TCGA Cosmic
rs779081435	p.Ala202Val	missense variant	-	NC_000018.10:g.28009814G>A	ExAC,TOPMed,gnomAD
rs1411133816	p.Asp203Glu	missense variant	-	NC_000018.10:g.28009810G>T	gnomAD
rs754074697	p.Gln204Glu	missense variant	-	NC_000018.10:g.28009809G>C	ExAC,gnomAD
rs766594147	p.Pro205Leu	missense variant	-	NC_000018.10:g.28009805G>A	ExAC,gnomAD
rs566720668	p.Pro205Ser	missense variant	-	NC_000018.10:g.28009806G>A	1000Genomes
NCI-TCGA novel	p.Pro206Thr	missense variant	-	NC_000018.10:g.28009803G>T	NCI-TCGA
rs1386798655	p.Thr207Asn	missense variant	-	NC_000018.10:g.28009799G>T	gnomAD
rs150141832	p.Thr207Ser	missense variant	-	NC_000018.10:g.28009800T>A	ESP,ExAC,TOPMed,gnomAD
rs150141832	p.Thr207Ala	missense variant	-	NC_000018.10:g.28009800T>C	ESP,ExAC,TOPMed,gnomAD
COSM5933695	p.Gly208Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28009797C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Phe210Leu	missense variant	-	NC_000018.10:g.28009789G>T	NCI-TCGA
rs1041972	p.Ile212Leu	missense variant	-	NC_000018.10:g.28009785T>G	UniProt,dbSNP
VAR_028257	p.Ile212Leu	missense variant	-	NC_000018.10:g.28009785T>G	UniProt
rs1041972	p.Ile212Leu	missense variant	-	NC_000018.10:g.28009785T>G	-
rs1445536352	p.Asn213Ser	missense variant	-	NC_000018.10:g.28009781T>C	TOPMed,gnomAD
NCI-TCGA novel	p.Pro214His	missense variant	-	NC_000018.10:g.28009778G>T	NCI-TCGA
COSM3524717	p.Pro214Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28009779G>A	NCI-TCGA Cosmic
rs762240435	p.Pro214Ala	missense variant	-	NC_000018.10:g.28009779G>C	ExAC,TOPMed,gnomAD
rs199664916	p.Ser216Leu	missense variant	-	NC_000018.10:g.28009772G>A	ESP,ExAC,TOPMed,gnomAD
rs199534055	p.Ser220Leu	missense variant	-	NC_000018.10:g.28009760G>A	ExAC,gnomAD
rs1257768241	p.Thr222Ile	missense variant	-	NC_000018.10:g.28009754G>A	TOPMed
rs1340647299	p.Pro224Thr	missense variant	-	NC_000018.10:g.28009749G>T	gnomAD
NCI-TCGA novel	p.Asp226Asn	missense variant	-	NC_000018.10:g.28009743C>T	NCI-TCGA
rs769462371	p.Arg227His	missense variant	-	NC_000018.10:g.28009739C>T	ExAC,TOPMed,gnomAD
rs997137643	p.Arg227Cys	missense variant	-	NC_000018.10:g.28009740G>A	TOPMed,gnomAD
rs781072123	p.Gln229Glu	missense variant	-	NC_000018.10:g.28009734G>C	ExAC,gnomAD
rs965753331	p.Gln229Arg	missense variant	-	NC_000018.10:g.28009733T>C	gnomAD
rs747002190	p.Ala231Ser	missense variant	-	NC_000018.10:g.28009728C>A	ExAC,gnomAD
rs202029952	p.Arg232Trp	missense variant	-	NC_000018.10:g.28009725G>A	ExAC,gnomAD
rs753933914	p.Arg232Gln	missense variant	-	NC_000018.10:g.28009724C>T	ExAC,TOPMed,gnomAD
rs202029952	p.Arg232Gly	missense variant	-	NC_000018.10:g.28009725G>C	ExAC,gnomAD
rs1413369773	p.His234Arg	missense variant	-	NC_000018.10:g.28009718T>C	gnomAD
rs1192216323	p.Ala237Ser	missense variant	-	NC_000018.10:g.28005987C>A	gnomAD
COSM987342	p.His238Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28005983T>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ala239Ser	missense variant	-	NC_000018.10:g.28005981C>A	NCI-TCGA
rs565814282	p.Asp241Glu	missense variant	-	NC_000018.10:g.28005973A>T	1000Genomes,ExAC,gnomAD
COSM987341	p.Gln246Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000018.10:g.28005960G>A	NCI-TCGA Cosmic
rs1245403455	p.Gln246His	missense variant	-	NC_000018.10:g.28005958T>A	TOPMed,gnomAD
NCI-TCGA novel	p.Ile251Thr	missense variant	-	NC_000018.10:g.28005944A>G	NCI-TCGA
rs1329481665	p.Ile251Val	missense variant	-	NC_000018.10:g.28005945T>C	gnomAD
rs751897139	p.Ile253Val	missense variant	-	NC_000018.10:g.28005939T>C	ExAC,gnomAD
rs1465038852	p.Asn256Ser	missense variant	-	NC_000018.10:g.28005929T>C	TOPMed
rs878882795	p.Asn256Lys	missense variant	-	NC_000018.10:g.28005928A>T	TOPMed
rs1409622589	p.Met260Leu	missense variant	-	NC_000018.10:g.28005918T>A	TOPMed
NCI-TCGA novel	p.Asp262Tyr	missense variant	-	NC_000018.10:g.28005912C>A	NCI-TCGA
COSM1200448	p.Phe267Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28005895G>T	NCI-TCGA Cosmic
rs1229222461	p.His269Arg	missense variant	-	NC_000018.10:g.28005890T>C	TOPMed
NCI-TCGA novel	p.Gln270Pro	missense variant	-	NC_000018.10:g.28005887T>G	NCI-TCGA
COSM4071674	p.Trp272Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28005880C>A	NCI-TCGA Cosmic
COSM70113	p.Trp272Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28005882A>T	NCI-TCGA Cosmic
rs764528943	p.Trp272Gly	missense variant	-	NC_000018.10:g.28005882A>C	ExAC,gnomAD
rs758876499	p.Asn273Ser	missense variant	-	NC_000018.10:g.28005878T>C	ExAC,gnomAD
NCI-TCGA novel	p.Gly274Trp	missense variant	-	NC_000018.10:g.28005876C>A	NCI-TCGA
rs1365406186	p.Val276Phe	missense variant	-	NC_000018.10:g.28005870C>A	gnomAD
NCI-TCGA novel	p.Pro277His	missense variant	-	NC_000018.10:g.28005866G>T	NCI-TCGA
COSM3890842	p.Pro277Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28005867G>T	NCI-TCGA Cosmic
COSM3524716	p.Pro277Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28005867G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Glu278Lys	missense variant	-	NC_000018.10:g.28005864C>T	NCI-TCGA
NCI-TCGA novel	p.Glu278Gln	missense variant	-	NC_000018.10:g.28005864C>G	NCI-TCGA
COSM4560260	p.Gly279Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28005860C>T	NCI-TCGA Cosmic
rs1300747599	p.Gly279Arg	missense variant	-	NC_000018.10:g.28005861C>T	TOPMed
rs1290459524	p.Ser280Leu	missense variant	-	NC_000018.10:g.28005857G>A	gnomAD
NCI-TCGA novel	p.Lys281Arg	missense variant	-	NC_000018.10:g.28005854T>C	NCI-TCGA
rs764864158	p.Lys281Asn	missense variant	-	NC_000018.10:g.28005853C>A	ExAC,gnomAD
COSM987340	p.Pro282His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28005851G>T	NCI-TCGA Cosmic
rs1382300148	p.Thr284Ser	missense variant	-	NC_000018.10:g.28003167T>A	TOPMed
rs1389872035	p.Val286Leu	missense variant	-	NC_000018.10:g.28003161C>A	gnomAD
rs760335891	p.Val286Ala	missense variant	-	NC_000018.10:g.28003160A>G	ExAC,gnomAD
rs142589795	p.Val289Leu	missense variant	-	NC_000018.10:g.28003152C>G	ESP,ExAC,TOPMed,gnomAD
rs142589795	p.Val289Ile	missense variant	-	NC_000018.10:g.28003152C>T	ESP,ExAC,TOPMed,gnomAD
COSM473717	p.Ala291Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28003146C>T	NCI-TCGA Cosmic
rs958752112	p.Ile292Val	missense variant	-	NC_000018.10:g.28003143T>C	TOPMed
rs761508961	p.Ala294Val	missense variant	-	NC_000018.10:g.28003136G>A	ExAC,TOPMed,gnomAD
rs1199412138	p.Ala294Thr	missense variant	-	NC_000018.10:g.28003137C>T	gnomAD
rs761508961	p.Ala294Gly	missense variant	-	NC_000018.10:g.28003136G>C	ExAC,TOPMed,gnomAD
rs768554447	p.Asp296Asn	missense variant	-	NC_000018.10:g.28003131C>T	ExAC,TOPMed,gnomAD
rs200798903	p.Asn298Ser	missense variant	-	NC_000018.10:g.28003124T>C	ESP,ExAC,TOPMed,gnomAD
rs200798903	p.Asn298Ile	missense variant	-	NC_000018.10:g.28003124T>A	ESP,ExAC,TOPMed,gnomAD
rs201695474	p.Asn298Asp	missense variant	-	NC_000018.10:g.28003125T>C	ExAC,TOPMed,gnomAD
rs892895034	p.Ala299Thr	missense variant	-	NC_000018.10:g.28003122C>T	TOPMed,gnomAD
rs1342538298	p.Leu300Pro	missense variant	-	NC_000018.10:g.28003118A>G	gnomAD
rs374009883	p.Asn301Ser	missense variant	-	NC_000018.10:g.28003115T>C	ESP,TOPMed,gnomAD
COSM6148965	p.Gly302Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28003112C>A	NCI-TCGA Cosmic
rs184596097	p.Gly302Glu	missense variant	-	NC_000018.10:g.28003112C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs777857003	p.Tyr306Cys	missense variant	-	NC_000018.10:g.28003100T>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ile308Val	missense variant	-	NC_000018.10:g.28003095T>C	NCI-TCGA
rs1431008052	p.Ile308Phe	missense variant	-	NC_000018.10:g.28003095T>A	gnomAD
rs146668864	p.Val309Leu	missense variant	-	NC_000018.10:g.28003092C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs146668864	p.Val309Met	missense variant	-	NC_000018.10:g.28003092C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs146668864	p.Val309Leu	missense variant	-	NC_000018.10:g.28003092C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
COSM987336	p.Ser310Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28003088G>T	NCI-TCGA Cosmic
rs542324094	p.Ser314Asn	missense variant	-	NC_000018.10:g.28003076C>T	1000Genomes,ExAC
rs753401951	p.Ser317Leu	missense variant	-	NC_000018.10:g.28003067G>A	ExAC,TOPMed,gnomAD
rs779651386	p.Pro318Arg	missense variant	-	NC_000018.10:g.28003064G>C	ExAC,gnomAD
rs143855545	p.Met320Val	missense variant	-	NC_000018.10:g.28003059T>C	ESP,ExAC,TOPMed,gnomAD
rs1019297487	p.Thr322Ala	missense variant	-	NC_000018.10:g.28003053T>C	TOPMed,gnomAD
rs1173487341	p.Ile323Val	missense variant	-	NC_000018.10:g.28003050T>C	TOPMed
rs1182264806	p.Ile323Thr	missense variant	-	NC_000018.10:g.28003049A>G	gnomAD
rs369552063	p.Asn325Ser	missense variant	-	NC_000018.10:g.28003043T>C	ESP,ExAC,gnomAD
NCI-TCGA novel	p.Glu326Lys	missense variant	-	NC_000018.10:g.28003041C>T	NCI-TCGA
NCI-TCGA novel	p.Thr327Ile	missense variant	-	NC_000018.10:g.28003037G>A	NCI-TCGA
NCI-TCGA novel	p.Gly328Cys	missense variant	-	NC_000018.10:g.28003035C>A	NCI-TCGA
rs1224469921	p.Asp329Val	missense variant	-	NC_000018.10:g.28003031T>A	gnomAD
rs1224469921	p.Asp329Gly	missense variant	-	NC_000018.10:g.28003031T>C	gnomAD
rs761713124	p.Ile330Val	missense variant	-	NC_000018.10:g.28003029T>C	ExAC,gnomAD
rs200593657	p.Ile331Val	missense variant	-	NC_000018.10:g.28003026T>C	ExAC,gnomAD
rs764046987	p.Thr332Ala	missense variant	-	NC_000018.10:g.28003023T>C	ExAC,TOPMed,gnomAD
rs1410496390	p.Val333Met	missense variant	-	NC_000018.10:g.28003020C>T	gnomAD
NCI-TCGA novel	p.Ala334Val	missense variant	-	NC_000018.10:g.28003016G>A	NCI-TCGA
rs762821933	p.Ala335Gly	missense variant	-	NC_000018.10:g.28003013G>C	ExAC,gnomAD
COSM279766	p.Gly336Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28003010C>A	NCI-TCGA Cosmic
rs1391837593	p.Leu337Pro	missense variant	-	NC_000018.10:g.28003007A>G	gnomAD
rs199703048	p.Arg339Ter	stop gained	-	NC_000018.10:g.28003002G>A	ExAC,TOPMed,gnomAD
rs201205775	p.Arg339Gln	missense variant	-	NC_000018.10:g.28003001C>T	gnomAD
rs199703048	p.Arg339Gly	missense variant	-	NC_000018.10:g.28003002G>C	ExAC,TOPMed,gnomAD
COSM274476	p.Glu340Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.28002999C>T	NCI-TCGA Cosmic
rs1177948036	p.Lys341Glu	missense variant	-	NC_000018.10:g.27993637T>C	NCI-TCGA
rs1478351166	p.Lys341Arg	missense variant	-	NC_000018.10:g.27993636T>C	gnomAD
rs1478351166	p.Lys341Thr	missense variant	-	NC_000018.10:g.27993636T>G	gnomAD
rs1177948036	p.Lys341Glu	missense variant	-	NC_000018.10:g.27993637T>C	gnomAD
rs1300965782	p.Val342Met	missense variant	-	NC_000018.10:g.27993634C>T	TOPMed
rs773126408	p.Val342Ala	missense variant	-	NC_000018.10:g.27993633A>G	ExAC
rs376933549	p.Gln343Arg	missense variant	-	NC_000018.10:g.27993630T>C	ESP,ExAC,TOPMed,gnomAD
rs200230960	p.Gln343Lys	missense variant	-	NC_000018.10:g.27993631G>T	ExAC,TOPMed,gnomAD
rs376933549	p.Gln343Pro	missense variant	-	NC_000018.10:g.27993630T>G	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gln344Lys	missense variant	-	NC_000018.10:g.27993628G>T	NCI-TCGA
rs774700140	p.Tyr345Phe	missense variant	-	NC_000018.10:g.27993624T>A	ExAC,gnomAD
rs749639068	p.Thr346Met	missense variant	-	NC_000018.10:g.27993621G>A	NCI-TCGA,NCI-TCGA Cosmic
rs749639068	p.Thr346Met	missense variant	-	NC_000018.10:g.27993621G>A	ExAC,TOPMed,gnomAD
rs749639068	p.Thr346Arg	missense variant	-	NC_000018.10:g.27993621G>C	ExAC,TOPMed,gnomAD
rs1274037988	p.Ile348Val	missense variant	-	NC_000018.10:g.27993616T>C	TOPMed,gnomAD
rs770147491	p.Ile348Thr	missense variant	-	NC_000018.10:g.27993615A>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ile349Leu	missense variant	-	NC_000018.10:g.27993613T>G	NCI-TCGA
rs1346388630	p.Thr352Ala	missense variant	-	NC_000018.10:g.27993604T>C	TOPMed,gnomAD
rs1209862742	p.Asn357Ser	missense variant	-	NC_000018.10:g.27993588T>C	TOPMed
rs1209862742	p.Asn357Ser	missense variant	-	NC_000018.10:g.27993588T>C	NCI-TCGA Cosmic
rs1231569307	p.Asn357Asp	missense variant	-	NC_000018.10:g.27993589T>C	gnomAD
COSM987335	p.Gly361Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27993576C>T	NCI-TCGA Cosmic
rs1297894688	p.Gly361Ser	missense variant	-	NC_000018.10:g.27993577C>T	gnomAD
COSM4071671	p.Leu362Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27993574G>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Thr365Ser	missense variant	-	NC_000018.10:g.27993565T>A	NCI-TCGA
NCI-TCGA novel	p.Ala366Thr	missense variant	-	NC_000018.10:g.27993562C>T	NCI-TCGA
COSM6148967	p.Ala366Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27993561G>T	NCI-TCGA Cosmic
rs200933425	p.Thr367Met	missense variant	-	NC_000018.10:g.27993558G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs756781191	p.Thr367Ala	missense variant	-	NC_000018.10:g.27993559T>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala368Ser	missense variant	-	NC_000018.10:g.27993556C>A	NCI-TCGA
rs1230791486	p.Ala368Thr	missense variant	-	NC_000018.10:g.27993556C>T	TOPMed,gnomAD
rs1230791486	p.Ala368Thr	missense variant	-	NC_000018.10:g.27993556C>T	NCI-TCGA Cosmic
rs149610799	p.Val369Ile	missense variant	-	NC_000018.10:g.27993553C>T	ESP,ExAC,TOPMed,gnomAD
rs765252957	p.Ile370Phe	missense variant	-	NC_000018.10:g.27993550T>A	ExAC,gnomAD
rs750531758	p.Asn376Ser	missense variant	-	NC_000018.10:g.27993531T>C	ExAC,gnomAD
rs1212363792	p.Asn378His	missense variant	-	NC_000018.10:g.27993526T>G	gnomAD
rs199977445	p.Asn378Ser	missense variant	-	NC_000018.10:g.27993525T>C	ExAC,gnomAD
COSM3524715	p.Pro379Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27993522G>A	NCI-TCGA Cosmic
rs867449013	p.Pro379Ser	missense variant	-	NC_000018.10:g.27993523G>A	gnomAD
rs867449013	p.Pro379Thr	missense variant	-	NC_000018.10:g.27993523G>T	gnomAD
NCI-TCGA novel	p.Ala384Val	missense variant	-	NC_000018.10:g.27993507G>A	NCI-TCGA
rs1397542114	p.Met385Val	missense variant	-	NC_000018.10:g.27993505T>C	gnomAD
rs764389179	p.Thr386Met	missense variant	-	NC_000018.10:g.27993501G>A	ExAC,gnomAD
NCI-TCGA novel	p.Phe387Leu	missense variant	-	NC_000018.10:g.27992838A>C	NCI-TCGA
COSM4071669	p.Tyr388Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27992837A>T	NCI-TCGA Cosmic
rs753115623	p.Gly389Ala	missense variant	-	NC_000018.10:g.27992833C>G	ExAC,TOPMed,gnomAD
rs753115623	p.Gly389Asp	missense variant	-	NC_000018.10:g.27992833C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg395Met	missense variant	-	NC_000018.10:g.27992815C>A	NCI-TCGA
rs200655366	p.Asp397Gly	missense variant	-	NC_000018.10:g.27992809T>C	1000Genomes,TOPMed,gnomAD
rs1479938758	p.Ile398Ser	missense variant	-	NC_000018.10:g.27992806A>C	gnomAD
COSM6083214	p.Ile399Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27992804T>A	NCI-TCGA Cosmic
rs150850339	p.Ile399Thr	missense variant	-	NC_000018.10:g.27992803A>G	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Val400Leu	missense variant	-	NC_000018.10:g.27992801C>A	NCI-TCGA
rs1297670315	p.Ala401Asp	missense variant	-	NC_000018.10:g.27992797G>T	TOPMed
rs1450731942	p.Thr404Ile	missense variant	-	NC_000018.10:g.27992788G>A	gnomAD
rs771423706	p.Val405Met	missense variant	-	NC_000018.10:g.27992786C>T	NCI-TCGA
rs771423706	p.Val405Met	missense variant	-	NC_000018.10:g.27992786C>T	ExAC,TOPMed,gnomAD
rs568089577	p.Asp407Asn	missense variant	-	NC_000018.10:g.27992780C>T	1000Genomes,ExAC,gnomAD
rs568089577	p.Asp407Asn	missense variant	-	NC_000018.10:g.27992780C>T	NCI-TCGA,NCI-TCGA Cosmic
rs778620928	p.Gln410Ter	stop gained	-	NC_000018.10:g.27992771G>A	ExAC,gnomAD
rs1270005384	p.His412Pro	missense variant	-	NC_000018.10:g.27992764T>G	TOPMed
rs779873167	p.Ala415Gly	missense variant	-	NC_000018.10:g.27992755G>C	ExAC,gnomAD
rs199631702	p.Ala415Thr	missense variant	-	NC_000018.10:g.27992756C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs199631702	p.Ala415Ser	missense variant	-	NC_000018.10:g.27992756C>A	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Asn417Lys	missense variant	-	NC_000018.10:g.27992748G>C	NCI-TCGA
rs1185237692	p.Asn417Ser	missense variant	-	NC_000018.10:g.27992749T>C	TOPMed
NCI-TCGA novel	p.Ala418Ser	missense variant	-	NC_000018.10:g.27992747C>A	NCI-TCGA
rs200263846	p.Ala418Thr	missense variant	-	NC_000018.10:g.27992747C>T	ESP,ExAC,TOPMed,gnomAD
rs200263846	p.Ala418Thr	missense variant	-	NC_000018.10:g.27992747C>T	NCI-TCGA,NCI-TCGA Cosmic
rs758537458	p.Val419Glu	missense variant	-	NC_000018.10:g.27992743A>T	ExAC,gnomAD
COSM708207	p.Arg421Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27992737C>G	NCI-TCGA Cosmic
COSM4524272	p.Arg421Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27992737C>T	NCI-TCGA Cosmic
rs202058357	p.Arg421Ser	missense variant	-	NC_000018.10:g.27992736T>A	ExAC,gnomAD
COSM6083215	p.Ser423Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27992730A>C	NCI-TCGA Cosmic
rs201382169	p.Gly425Arg	missense variant	-	NC_000018.10:g.27992726C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro427Ser	missense variant	-	NC_000018.10:g.27992720G>A	NCI-TCGA
NCI-TCGA novel	p.Pro427Thr	missense variant	-	NC_000018.10:g.27992720G>T	NCI-TCGA
NCI-TCGA novel	p.Thr428Ile	missense variant	-	NC_000018.10:g.27992716G>A	NCI-TCGA
rs766881004	p.Gly429Glu	missense variant	-	NC_000018.10:g.27992713C>T	ExAC,gnomAD
rs202198632	p.Arg430Gln	missense variant	-	NC_000018.10:g.27992710C>T	NCI-TCGA,NCI-TCGA Cosmic
rs199882009	p.Arg430Trp	missense variant	-	NC_000018.10:g.27992711G>A	ExAC,TOPMed,gnomAD
rs202198632	p.Arg430Leu	missense variant	-	NC_000018.10:g.27992710C>A	ExAC,TOPMed,gnomAD
rs199882009	p.Arg430Trp	missense variant	-	NC_000018.10:g.27992711G>A	NCI-TCGA,NCI-TCGA Cosmic
rs202198632	p.Arg430Gln	missense variant	-	NC_000018.10:g.27992710C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe431Ser	missense variant	-	NC_000018.10:g.27992707A>G	NCI-TCGA
rs1218458192	p.Ala432Thr	missense variant	-	NC_000018.10:g.27992705C>T	NCI-TCGA
rs1218458192	p.Ala432Thr	missense variant	-	NC_000018.10:g.27992705C>T	gnomAD
rs142861371	p.Asp436Asn	missense variant	-	NC_000018.10:g.27992693C>T	ESP,ExAC,TOPMed,gnomAD
rs142861371	p.Asp436Asn	missense variant	-	NC_000018.10:g.27992693C>T	NCI-TCGA
NCI-TCGA novel	p.Pro437Ser	missense variant	-	NC_000018.10:g.27992690G>A	NCI-TCGA
rs17853634	p.Pro437Gln	missense variant	-	NC_000018.10:g.27992689G>T	ExAC,gnomAD
rs17853634	p.Pro437Leu	missense variant	-	NC_000018.10:g.27992689G>A	ExAC,gnomAD
rs17853634	p.Pro437Leu	missense variant	-	NC_000018.10:g.27992689G>A	NCI-TCGA,NCI-TCGA Cosmic
rs769866300	p.Asn438Ser	missense variant	-	NC_000018.10:g.27992686T>C	ExAC,gnomAD
rs1361440922	p.Ser439Gly	missense variant	-	NC_000018.10:g.27992684T>C	gnomAD
rs781246502	p.Asp441Asn	missense variant	-	NC_000018.10:g.27992678C>T	ExAC,TOPMed,gnomAD
rs748210936	p.Asp441Glu	missense variant	-	NC_000018.10:g.27992676G>T	ExAC,TOPMed,gnomAD
rs200033452	p.Thr445Ser	missense variant	-	NC_000018.10:g.27992665G>C	TOPMed,gnomAD
rs200033452	p.Thr445Asn	missense variant	-	NC_000018.10:g.27992665G>T	TOPMed,gnomAD
rs200033452	p.Thr445Ser	missense variant	-	NC_000018.10:g.27992665G>C	NCI-TCGA
rs377069261	p.Val446Met	missense variant	-	NC_000018.10:g.27992663C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs776502285	p.Pro449Leu	missense variant	-	NC_000018.10:g.27990349G>A	ExAC
rs759436092	p.Pro449Ala	missense variant	-	NC_000018.10:g.27990350G>C	ExAC,TOPMed,gnomAD
rs759436092	p.Pro449Thr	missense variant	-	NC_000018.10:g.27990350G>T	ExAC,TOPMed,gnomAD
rs200254715	p.Ile450Met	missense variant	-	NC_000018.10:g.27990345G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs200762335	p.Ile450Phe	missense variant	-	NC_000018.10:g.27990347T>A	ExAC,TOPMed,gnomAD
rs200762335	p.Ile450Val	missense variant	-	NC_000018.10:g.27990347T>C	ExAC,TOPMed,gnomAD
rs773021925	p.Asp451Asn	missense variant	-	NC_000018.10:g.27990344C>T	ExAC,gnomAD
rs773021925	p.Asp451Asn	missense variant	-	NC_000018.10:g.27990344C>T	NCI-TCGA,NCI-TCGA Cosmic
COSM987334	p.Glu453Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27990338C>G	NCI-TCGA Cosmic
rs768822745	p.Glu453Ter	stop gained	-	NC_000018.10:g.27990338C>A	ExAC,gnomAD
NCI-TCGA novel	p.Thr454Lys	missense variant	-	NC_000018.10:g.27990334G>T	NCI-TCGA
rs1387623128	p.Thr454Arg	missense variant	-	NC_000018.10:g.27990334G>C	gnomAD
rs17857112	p.Thr454Ala	missense variant	-	NC_000018.10:g.27990335T>C	-
rs17857112	p.Thr454Ala	missense variant	-	NC_000018.10:g.27990335T>C	UniProt,dbSNP
VAR_048503	p.Thr454Ala	missense variant	-	NC_000018.10:g.27990335T>C	UniProt
rs529923349	p.Asn455Ser	missense variant	-	NC_000018.10:g.27990331T>C	1000Genomes,ExAC,gnomAD
rs1290759313	p.Arg456Lys	missense variant	-	NC_000018.10:g.27990328C>T	TOPMed
rs562836496	p.Met457Val	missense variant	-	NC_000018.10:g.27990326T>C	1000Genomes,ExAC,gnomAD
rs746232611	p.Leu460Phe	missense variant	-	NC_000018.10:g.27990317G>A	ExAC,gnomAD
rs201799084	p.Thr461Ile	missense variant	-	NC_000018.10:g.27990313G>A	ExAC,TOPMed,gnomAD
rs1329166602	p.Thr461Pro	missense variant	-	NC_000018.10:g.27990314T>G	TOPMed
rs1275974054	p.Val462Leu	missense variant	-	NC_000018.10:g.27990311C>G	TOPMed
rs1368666457	p.Ala463Thr	missense variant	-	NC_000018.10:g.27990308C>T	gnomAD
COSM987333	p.Glu465Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27990302C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Asn466Ile	missense variant	-	NC_000018.10:g.27990298T>A	NCI-TCGA
NCI-TCGA novel	p.Gln467Glu	missense variant	-	NC_000018.10:g.27990296G>C	NCI-TCGA
rs1473917332	p.Lys472Glu	missense variant	-	NC_000018.10:g.27990281T>C	gnomAD
rs778109471	p.Gly473Glu	missense variant	-	NC_000018.10:g.27990277C>T	ExAC,gnomAD
rs1481966925	p.Ile474Val	missense variant	-	NC_000018.10:g.27990275T>C	TOPMed
rs752215297	p.His476Arg	missense variant	-	NC_000018.10:g.27990268T>C	ExAC,gnomAD
rs752215297	p.His476Pro	missense variant	-	NC_000018.10:g.27990268T>G	ExAC,gnomAD
rs182701313	p.Pro477Leu	missense variant	-	NC_000018.10:g.27990265G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs182701313	p.Pro477His	missense variant	-	NC_000018.10:g.27990265G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1489617243	p.Gln479Ter	stop gained	-	NC_000018.10:g.27990260G>A	gnomAD
rs374121586	p.Gln479Arg	missense variant	-	NC_000018.10:g.27990259T>C	ESP,ExAC,TOPMed,gnomAD
COSM6148969	p.Ala482Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27990251C>A	NCI-TCGA Cosmic
rs17853633	p.Val484Met	missense variant	-	NC_000018.10:g.27990245C>T	ExAC,gnomAD
rs771852330	p.Val484Ala	missense variant	-	NC_000018.10:g.27990244A>G	ExAC,gnomAD
rs763047448	p.Ser485Thr	missense variant	-	NC_000018.10:g.27990242A>T	ExAC,gnomAD
rs1428236027	p.Val486Leu	missense variant	-	NC_000018.10:g.27990239C>G	TOPMed
rs1428236027	p.Val486Ile	missense variant	-	NC_000018.10:g.27990239C>T	TOPMed
rs1327331010	p.Thr487Ile	missense variant	-	NC_000018.10:g.27990235G>A	gnomAD
rs1236877209	p.Ile489Thr	missense variant	-	NC_000018.10:g.27990229A>G	TOPMed,gnomAD
rs201148355	p.Val491Ile	missense variant	-	NC_000018.10:g.27990224C>T	NCI-TCGA,NCI-TCGA Cosmic
COSM3524710	p.Val491Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27990224C>A	NCI-TCGA Cosmic
rs201148355	p.Val491Leu	missense variant	-	NC_000018.10:g.27990224C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs201148355	p.Val491Ile	missense variant	-	NC_000018.10:g.27990224C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu493Val	missense variant	-	NC_000018.10:g.27990217T>A	NCI-TCGA
rs781265304	p.Asn494Asp	missense variant	-	NC_000018.10:g.27990215T>C	ExAC,gnomAD
rs771364472	p.Asn494Lys	missense variant	-	NC_000018.10:g.27990213G>T	ExAC,gnomAD
rs200059562	p.Pro495Ala	missense variant	-	NC_000018.10:g.27990212G>C	ExAC,TOPMed,gnomAD
rs200059562	p.Pro495Thr	missense variant	-	NC_000018.10:g.27990212G>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe497LeuPheSerTerUnkUnk	frameshift	-	NC_000018.10:g.27990204A>-	NCI-TCGA
NCI-TCGA novel	p.Phe497Leu	missense variant	-	NC_000018.10:g.27990206A>G	NCI-TCGA
rs1159250321	p.Pro499Ala	missense variant	-	NC_000018.10:g.27990200G>C	gnomAD
rs1272545722	p.Pro499Arg	missense variant	-	NC_000018.10:g.27990199G>C	TOPMed
NCI-TCGA novel	p.Asn500LysPheSerTerUnk	frameshift	-	NC_000018.10:g.27990195_27990196insT	NCI-TCGA
rs201866479	p.Asn500Ser	missense variant	-	NC_000018.10:g.27990196T>C	ExAC,TOPMed,gnomAD
COSM6083216	p.Pro501Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27990193G>C	NCI-TCGA Cosmic
COSM5603130	p.Pro501Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27990194G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Lys502Asn	missense variant	-	NC_000018.10:g.27990189C>A	NCI-TCGA
rs778627728	p.Lys502Asn	missense variant	-	NC_000018.10:g.27990189C>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ile504Asn	missense variant	-	NC_000018.10:g.27990184A>T	NCI-TCGA
rs754534891	p.Ile504Val	missense variant	-	NC_000018.10:g.27990185T>C	ExAC,gnomAD
rs753588105	p.Arg505Cys	missense variant	-	NC_000018.10:g.27990182G>A	NCI-TCGA,NCI-TCGA Cosmic
rs753588105	p.Arg505Cys	missense variant	-	NC_000018.10:g.27990182G>A	ExAC,TOPMed,gnomAD
rs143201939	p.Arg505His	missense variant	-	NC_000018.10:g.27990181C>T	ESP,ExAC,TOPMed,gnomAD
rs143201939	p.Arg505Leu	missense variant	-	NC_000018.10:g.27990181C>A	ESP,ExAC,TOPMed,gnomAD
rs143201939	p.Arg505His	missense variant	-	NC_000018.10:g.27990181C>T	NCI-TCGA,NCI-TCGA Cosmic
rs750142878	p.Gly509Arg	missense variant	-	NC_000018.10:g.27990170C>T	NCI-TCGA,NCI-TCGA Cosmic
rs750142878	p.Gly509Trp	missense variant	-	NC_000018.10:g.27990170C>A	ExAC,TOPMed,gnomAD
rs750142878	p.Gly509Arg	missense variant	-	NC_000018.10:g.27990170C>T	ExAC,TOPMed,gnomAD
COSM1388195	p.His511Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27990163T>C	NCI-TCGA Cosmic
rs879152118	p.Ala512Val	missense variant	-	NC_000018.10:g.27990160G>A	TOPMed,gnomAD
rs1196731334	p.Ala512Thr	missense variant	-	NC_000018.10:g.27990161C>T	TOPMed
rs879152118	p.Ala512Gly	missense variant	-	NC_000018.10:g.27990160G>C	TOPMed,gnomAD
COSM6083217	p.Gly513Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27990157C>A	NCI-TCGA Cosmic
rs1235894596	p.Gly513Asp	missense variant	-	NC_000018.10:g.27990157C>T	gnomAD
rs201838069	p.Gly513Arg	missense variant	-	NC_000018.10:g.27990158C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs201838069	p.Gly513Ser	missense variant	-	NC_000018.10:g.27990158C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs765366885	p.Thr514Ile	missense variant	-	NC_000018.10:g.27990154G>A	ExAC,gnomAD
rs1303115025	p.Met515Val	missense variant	-	NC_000018.10:g.27990152T>C	gnomAD
rs759578721	p.Met515Arg	missense variant	-	NC_000018.10:g.27990151A>C	ExAC,TOPMed,gnomAD
rs1405234964	p.Thr517Ile	missense variant	-	NC_000018.10:g.27990145G>A	TOPMed
rs1405234964	p.Thr517Arg	missense variant	-	NC_000018.10:g.27990145G>C	TOPMed
rs149079132	p.Thr518Ala	missense variant	-	NC_000018.10:g.27990143T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe519Leu	missense variant	-	NC_000018.10:g.27990138G>T	NCI-TCGA
rs771020355	p.Phe519Leu	missense variant	-	NC_000018.10:g.27990140A>G	ExAC,TOPMed,gnomAD
rs138057585	p.Thr520Ala	missense variant	-	NC_000018.10:g.27990137T>C	ESP,ExAC,TOPMed,gnomAD
rs138057585	p.Thr520Pro	missense variant	-	NC_000018.10:g.27990137T>G	ESP,ExAC,TOPMed,gnomAD
rs748735492	p.Arg526Ter	stop gained	-	NC_000018.10:g.27990119G>A	NCI-TCGA Cosmic
rs748735492	p.Arg526Gly	missense variant	-	NC_000018.10:g.27990119G>C	ExAC,gnomAD
rs748735492	p.Arg526Ter	stop gained	-	NC_000018.10:g.27990119G>A	ExAC,gnomAD
rs150313483	p.Arg526Gln	missense variant	-	NC_000018.10:g.27990118C>T	NCI-TCGA,NCI-TCGA Cosmic
rs150313483	p.Arg526Gln	missense variant	-	NC_000018.10:g.27990118C>T	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Tyr527His	missense variant	-	NC_000018.10:g.27990116A>G	NCI-TCGA
rs754586246	p.Met528Leu	missense variant	-	NC_000018.10:g.27990113T>A	ExAC,gnomAD
rs748700492	p.Met528Ile	missense variant	-	NC_000018.10:g.27990111C>G	ExAC
rs1189336898	p.Gln530Arg	missense variant	-	NC_000018.10:g.27990106T>C	TOPMed,gnomAD
COSM708209	p.Arg533Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27990098T>C	NCI-TCGA Cosmic
rs1270723918	p.Thr535Ser	missense variant	-	NC_000018.10:g.27988662T>A	TOPMed,gnomAD
rs546438155	p.Thr535Ile	missense variant	-	NC_000018.10:g.27988661G>A	ExAC,TOPMed,gnomAD
rs546438155	p.Thr535Ser	missense variant	-	NC_000018.10:g.27988661G>C	ExAC,TOPMed,gnomAD
rs745573480	p.Leu537Val	missense variant	-	NC_000018.10:g.27988656A>C	ExAC,gnomAD
rs370514300	p.Ser538Cys	missense variant	-	NC_000018.10:g.27988652G>C	ESP,ExAC,TOPMed,gnomAD
rs370514300	p.Ser538Tyr	missense variant	-	NC_000018.10:g.27988652G>T	ESP,ExAC,TOPMed,gnomAD
rs1327936760	p.Asp539Tyr	missense variant	-	NC_000018.10:g.27988650C>A	gnomAD
COSM3524709	p.Pro540Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27988646G>A	NCI-TCGA Cosmic
rs1409652618	p.Ala541Thr	missense variant	-	NC_000018.10:g.27988644C>T	gnomAD
rs1409652618	p.Ala541Ser	missense variant	-	NC_000018.10:g.27988644C>A	gnomAD
rs140291781	p.Asn542Ser	missense variant	-	NC_000018.10:g.27988640T>C	ESP
NCI-TCGA novel	p.Leu544Gln	missense variant	-	NC_000018.10:g.27988634A>T	NCI-TCGA
rs202132709	p.Lys545Asn	missense variant	-	NC_000018.10:g.27988630T>G	gnomAD
NCI-TCGA novel	p.Ile546LysPheSerTerUnk	frameshift	-	NC_000018.10:g.27988628A>-	NCI-TCGA
rs1475551106	p.Ile546Val	missense variant	-	NC_000018.10:g.27988629T>C	gnomAD
COSM183546	p.Asp547Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27988626C>A	NCI-TCGA Cosmic
rs1320677700	p.Pro548Ser	missense variant	-	NC_000018.10:g.27988623G>A	TOPMed,gnomAD
rs201042909	p.Val549Met	missense variant	-	NC_000018.10:g.27988620C>T	ExAC,gnomAD
COSM708210	p.Gly551Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27988613C>T	NCI-TCGA Cosmic
rs199900123	p.Gly551Ala	missense variant	-	NC_000018.10:g.27988613C>G	TOPMed
rs764115203	p.Thr555Ala	missense variant	-	NC_000018.10:g.27988602T>C	gnomAD
rs1486274548	p.Ile556Val	missense variant	-	NC_000018.10:g.27988599T>C	TOPMed
rs1247759762	p.Val558Ile	missense variant	-	NC_000018.10:g.27988593C>T	TOPMed
rs758212729	p.Arg561Gln	missense variant	-	NC_000018.10:g.27988583C>T	ExAC,TOPMed,gnomAD
rs758212729	p.Arg561Gln	missense variant	-	NC_000018.10:g.27988583C>T	NCI-TCGA Cosmic
rs758212729	p.Arg561Leu	missense variant	-	NC_000018.10:g.27988583C>A	ExAC,TOPMed,gnomAD
rs752667569	p.Glu562Ter	stop gained	-	NC_000018.10:g.27988581C>A	ExAC,gnomAD
rs752667569	p.Glu562Ter	stop gained	-	NC_000018.10:g.27988581C>A	NCI-TCGA
NCI-TCGA novel	p.Ser563Pro	missense variant	-	NC_000018.10:g.27988578A>G	NCI-TCGA
rs766437502	p.Asn565Ile	missense variant	-	NC_000018.10:g.27988571T>A	ExAC,gnomAD
rs752473363	p.Val566Met	missense variant	-	NC_000018.10:g.27988569C>T	ExAC,gnomAD
rs752473363	p.Val566Leu	missense variant	-	NC_000018.10:g.27988569C>A	ExAC,gnomAD
NCI-TCGA novel	p.Asn568Ser	missense variant	-	NC_000018.10:g.27988562T>C	NCI-TCGA
rs1291530759	p.Asn568Thr	missense variant	-	NC_000018.10:g.27988562T>G	gnomAD
rs1215813174	p.Asn569Ser	missense variant	-	NC_000018.10:g.27988559T>C	gnomAD
rs750664667	p.Ile570Met	missense variant	-	NC_000018.10:g.27988555T>C	ExAC
rs1228402305	p.Ile570Val	missense variant	-	NC_000018.10:g.27988557T>C	TOPMed,gnomAD
NCI-TCGA novel	p.Asn572IlePheSerTerUnkUnk	frameshift	-	NC_000018.10:g.27988550_27988551insTA	NCI-TCGA
rs962844318	p.Ala573Thr	missense variant	-	NC_000018.10:g.27988548C>T	gnomAD
rs762302781	p.Thr574Ala	missense variant	-	NC_000018.10:g.27988545T>C	ExAC,TOPMed,gnomAD
rs1175255093	p.Phe575Tyr	missense variant	-	NC_000018.10:g.27988541A>T	TOPMed
COSM1388194	p.Leu576Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27988538A>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ala577Asp	missense variant	-	NC_000018.10:g.27988535G>T	NCI-TCGA
rs1395482543	p.Ala577Thr	missense variant	-	NC_000018.10:g.27988536C>T	TOPMed
rs769297692	p.Asn580Ser	missense variant	-	NC_000018.10:g.27988526T>C	ExAC,gnomAD
rs774787740	p.Asn580Asp	missense variant	-	NC_000018.10:g.27988527T>C	ExAC,TOPMed,gnomAD
COSM5665814	p.Pro583Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985756G>A	NCI-TCGA Cosmic
rs1427781975	p.Pro583Leu	missense variant	-	NC_000018.10:g.27985755G>A	gnomAD
rs1194624307	p.Met585Ile	missense variant	-	NC_000018.10:g.27985748C>T	gnomAD
rs763345128	p.Thr588Ala	missense variant	-	NC_000018.10:g.27985741T>C	ExAC,gnomAD
rs775910155	p.Thr588Lys	missense variant	-	NC_000018.10:g.27985740G>T	ExAC,gnomAD
NCI-TCGA novel	p.Gly589Arg	missense variant	-	NC_000018.10:g.27985738C>T	NCI-TCGA
rs770284983	p.Gly589Ala	missense variant	-	NC_000018.10:g.27985737C>G	ExAC,gnomAD
rs201191002	p.Thr590Met	missense variant	-	NC_000018.10:g.27985734G>A	NCI-TCGA,NCI-TCGA Cosmic
rs199705934	p.Thr590Ala	missense variant	-	NC_000018.10:g.27985735T>C	gnomAD
rs201191002	p.Thr590Met	missense variant	-	NC_000018.10:g.27985734G>A	ExAC,TOPMed,gnomAD
rs201191002	p.Thr590Lys	missense variant	-	NC_000018.10:g.27985734G>T	ExAC,TOPMed,gnomAD
rs199833554	p.Tyr594Cys	missense variant	-	NC_000018.10:g.27985722T>C	1000Genomes,ExAC,gnomAD
COSM260024	p.Leu596Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985717G>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Asp597Glu	missense variant	-	NC_000018.10:g.27985712A>T	NCI-TCGA
rs201775968	p.Asn601Ser	missense variant	-	NC_000018.10:g.27985701T>C	1000Genomes,ExAC,TOPMed,gnomAD
rs777374626	p.Ala602Gly	missense variant	-	NC_000018.10:g.27985698G>C	ExAC,TOPMed,gnomAD
COSM2808351	p.Pro603His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985695G>T	NCI-TCGA Cosmic
rs1411707891	p.Gln604Lys	missense variant	-	NC_000018.10:g.27985693G>T	gnomAD
rs1440803773	p.Ala610Val	missense variant	-	NC_000018.10:g.27985674G>A	TOPMed
rs1288362921	p.Thr612Asn	missense variant	-	NC_000018.10:g.27985668G>T	gnomAD
rs750540712	p.Glu614Lys	missense variant	-	NC_000018.10:g.27985663C>T	ExAC,TOPMed,gnomAD
rs750540712	p.Glu614Lys	missense variant	-	NC_000018.10:g.27985663C>T	NCI-TCGA,NCI-TCGA Cosmic
NCI-TCGA novel	p.Thr615Asn	missense variant	-	NC_000018.10:g.27985659G>T	NCI-TCGA
rs781477117	p.Pro616Thr	missense variant	-	NC_000018.10:g.27985657G>T	ExAC,gnomAD
rs781477117	p.Pro616Ser	missense variant	-	NC_000018.10:g.27985657G>A	ExAC,gnomAD
rs757404285	p.Pro616Leu	missense variant	-	NC_000018.10:g.27985656G>A	ExAC,gnomAD
rs1422448817	p.Asp617Glu	missense variant	-	NC_000018.10:g.27985652G>T	TOPMed
NCI-TCGA novel	p.Pro618Thr	missense variant	-	NC_000018.10:g.27985651G>T	NCI-TCGA
rs1463744997	p.Asn619His	missense variant	-	NC_000018.10:g.27985648T>G	TOPMed
COSM987330	p.Ser620Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000018.10:g.27985644G>T	NCI-TCGA Cosmic
rs928874934	p.Ile621Val	missense variant	-	NC_000018.10:g.27985642T>C	TOPMed,gnomAD
rs1260513378	p.Asn622Ser	missense variant	-	NC_000018.10:g.27985638T>C	gnomAD
rs758709494	p.Ile623Val	missense variant	-	NC_000018.10:g.27985636T>C	ExAC,TOPMed,gnomAD
COSM3524707	p.Asp627Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985624C>T	NCI-TCGA Cosmic
rs753064228	p.Tyr628Cys	missense variant	-	NC_000018.10:g.27985620T>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro632Ala	missense variant	-	NC_000018.10:g.27985609G>C	NCI-TCGA
NCI-TCGA novel	p.Gly635Ter	stop gained	-	NC_000018.10:g.27985600C>A	NCI-TCGA
NCI-TCGA novel	p.Gly635Val	missense variant	-	NC_000018.10:g.27985599C>A	NCI-TCGA
rs1345401959	p.Gly635Arg	missense variant	-	NC_000018.10:g.27985600C>T	gnomAD
NCI-TCGA novel	p.Pro636Thr	missense variant	-	NC_000018.10:g.27985597G>T	NCI-TCGA
rs760095602	p.Asp640His	missense variant	-	NC_000018.10:g.27985585C>G	ExAC,gnomAD
rs1291687217	p.Leu641Val	missense variant	-	NC_000018.10:g.27985582G>C	TOPMed
COSM3524706	p.Pro642Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985578G>A	NCI-TCGA Cosmic
COSM708211	p.Pro642Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985579G>T	NCI-TCGA Cosmic
rs777119036	p.Pro642Ser	missense variant	-	NC_000018.10:g.27985579G>A	ExAC,gnomAD
rs199678478	p.Leu643Val	missense variant	-	NC_000018.10:g.27985576A>C	1000Genomes,ExAC,TOPMed,gnomAD
rs1284016891	p.Ser644Phe	missense variant	-	NC_000018.10:g.27985572G>A	TOPMed
NCI-TCGA novel	p.Pro645Ser	missense variant	-	NC_000018.10:g.27985570G>A	NCI-TCGA
NCI-TCGA novel	p.Pro645Arg	missense variant	-	NC_000018.10:g.27985569G>C	NCI-TCGA
rs760159166	p.Thr647Asn	missense variant	-	NC_000018.10:g.27985563G>T	ExAC,gnomAD
COSM70112	p.Ile648Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985561T>C	NCI-TCGA Cosmic
COSM438010	p.Arg650Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985554C>G	NCI-TCGA Cosmic
COSM279765	p.Arg650Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985554C>A	NCI-TCGA Cosmic
rs946014808	p.Thr655Ser	missense variant	-	NC_000018.10:g.27985539G>C	gnomAD
rs200324494	p.Arg656Trp	missense variant	-	NC_000018.10:g.27985537G>A	ExAC,TOPMed,gnomAD
rs1374084310	p.Arg656Gln	missense variant	-	NC_000018.10:g.27985536C>T	gnomAD
rs1394668941	p.Asp660Asn	missense variant	-	NC_000018.10:g.27985231C>T	gnomAD
rs202052912	p.Gln663Ter	stop gained	-	NC_000018.10:g.27985222G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs202052912	p.Gln663Glu	missense variant	-	NC_000018.10:g.27985222G>C	1000Genomes,ExAC,TOPMed,gnomAD
COSM1388192	p.Lys669Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985203T>G	NCI-TCGA Cosmic
rs1418219005	p.Lys669Asn	missense variant	-	NC_000018.10:g.27985202T>A	TOPMed,gnomAD
rs1182299572	p.Lys669Gln	missense variant	-	NC_000018.10:g.27985204T>G	gnomAD
COSM987329	p.Leu671Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985198G>T	NCI-TCGA Cosmic
rs767093257	p.Leu671Phe	missense variant	-	NC_000018.10:g.27985198G>A	ExAC,gnomAD
rs151218256	p.Glu672Asp	missense variant	-	NC_000018.10:g.27985193T>A	1000Genomes,ExAC,TOPMed,gnomAD
rs570047207	p.Glu672Ala	missense variant	-	NC_000018.10:g.27985194T>G	1000Genomes,ExAC,gnomAD
rs1273934223	p.Gly674Asp	missense variant	-	NC_000018.10:g.27985188C>T	gnomAD
rs199984052	p.Tyr676Phe	missense variant	-	NC_000018.10:g.27985182T>A	ExAC,TOPMed,gnomAD
rs201490302	p.Val678Gly	missense variant	-	NC_000018.10:g.27985176A>C	1000Genomes,ExAC,gnomAD
rs1240227564	p.Val678Phe	missense variant	-	NC_000018.10:g.27985177C>A	gnomAD
rs747090043	p.Pro679Ala	missense variant	-	NC_000018.10:g.27985174G>C	ExAC,gnomAD
rs1367227912	p.Thr683Ala	missense variant	-	NC_000018.10:g.27985162T>C	gnomAD
rs1371255423	p.Ser685Leu	missense variant	-	NC_000018.10:g.27985155G>A	NCI-TCGA
rs1371255423	p.Ser685Leu	missense variant	-	NC_000018.10:g.27985155G>A	gnomAD
rs377497277	p.Asn687Thr	missense variant	-	NC_000018.10:g.27985149T>G	ESP,ExAC,TOPMed,gnomAD
rs377497277	p.Asn687Ser	missense variant	-	NC_000018.10:g.27985149T>C	ESP,ExAC,TOPMed,gnomAD
rs1444982512	p.Pro688Leu	missense variant	-	NC_000018.10:g.27985146G>A	TOPMed
rs202027058	p.Ser691Thr	missense variant	-	NC_000018.10:g.27985138A>T	gnomAD
RCV000656331	p.Asn692Ser	missense variant	Cerebral arteriovenous malformation (BAVM)	NC_000018.10:g.27985134T>C	ClinVar
rs1555630396	p.Asn692Ser	missense variant	-	NC_000018.10:g.27985134T>C	-
COSM2808344	p.Ser694Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985128G>A	NCI-TCGA Cosmic
rs778982228	p.Ile695Val	missense variant	-	NC_000018.10:g.27985126T>C	ExAC,gnomAD
rs1452947996	p.Ile695Thr	missense variant	-	NC_000018.10:g.27985125A>G	gnomAD
rs755360931	p.Leu696Val	missense variant	-	NC_000018.10:g.27985123G>C	ExAC,gnomAD
rs754165315	p.Arg697Cys	missense variant	-	NC_000018.10:g.27985120G>A	NCI-TCGA
rs146657229	p.Arg697Leu	missense variant	-	NC_000018.10:g.27985119C>A	ESP,ExAC,TOPMed,gnomAD
rs754165315	p.Arg697Cys	missense variant	-	NC_000018.10:g.27985120G>A	ExAC,TOPMed,gnomAD
rs146657229	p.Arg697His	missense variant	-	NC_000018.10:g.27985119C>T	ESP,ExAC,TOPMed,gnomAD
rs767117514	p.Val698Met	missense variant	-	NC_000018.10:g.27985117C>T	ExAC,TOPMed,gnomAD
rs767117514	p.Val698Leu	missense variant	-	NC_000018.10:g.27985117C>G	ExAC,TOPMed,gnomAD
COSM4071666	p.Val700Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985110A>C	NCI-TCGA Cosmic
rs1027567929	p.Val700Phe	missense variant	-	NC_000018.10:g.27985111C>A	gnomAD
rs1027567929	p.Val700Ile	missense variant	-	NC_000018.10:g.27985111C>T	gnomAD
NCI-TCGA novel	p.Asp704His	missense variant	-	NC_000018.10:g.27985099C>G	NCI-TCGA
rs1206310024	p.Asp704Asn	missense variant	-	NC_000018.10:g.27985099C>T	gnomAD
rs763789703	p.Asp704Val	missense variant	-	NC_000018.10:g.27985098T>A	ExAC,gnomAD
rs775358499	p.Asn706Lys	missense variant	-	NC_000018.10:g.27985091G>C	ExAC,TOPMed,gnomAD
rs201333291	p.Asn706Ser	missense variant	-	NC_000018.10:g.27985092T>C	ExAC,TOPMed,gnomAD
rs200558954	p.Gly707Arg	missense variant	-	NC_000018.10:g.27985090C>T	ESP,ExAC,TOPMed,gnomAD
rs1176600992	p.Cys709Gly	missense variant	-	NC_000018.10:g.27985084A>C	gnomAD
rs370864272	p.Asp711His	missense variant	-	NC_000018.10:g.27985078C>G	ESP,ExAC,TOPMed,gnomAD
rs1318395524	p.Asp711Glu	missense variant	-	NC_000018.10:g.27985076A>T	gnomAD
rs772245129	p.Val712Met	missense variant	-	NC_000018.10:g.27985075C>T	ExAC,gnomAD
rs199712566	p.Asp713His	missense variant	-	NC_000018.10:g.27985072C>G	ExAC,TOPMed,gnomAD
rs199712566	p.Asp713Asn	missense variant	-	NC_000018.10:g.27985072C>T	ExAC,TOPMed,gnomAD
rs1435057861	p.Gly717Ser	missense variant	-	NC_000018.10:g.27985060C>T	gnomAD
rs201543789	p.Gly717Ala	missense variant	-	NC_000018.10:g.27985059C>G	ESP,ExAC,TOPMed,gnomAD
rs201543789	p.Gly717Asp	missense variant	-	NC_000018.10:g.27985059C>T	ESP,ExAC,TOPMed,gnomAD
rs201543789	p.Gly717Val	missense variant	-	NC_000018.10:g.27985059C>A	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala718Thr	missense variant	-	NC_000018.10:g.27985057C>T	NCI-TCGA
rs140836073	p.Ala718Val	missense variant	-	NC_000018.10:g.27985056G>A	ESP,ExAC,TOPMed,gnomAD
rs140836073	p.Ala718Val	missense variant	-	NC_000018.10:g.27985056G>A	NCI-TCGA,NCI-TCGA Cosmic
COSM987328	p.Leu720His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985050A>T	NCI-TCGA Cosmic
rs547585102	p.Leu720Pro	missense variant	-	NC_000018.10:g.27985050A>G	1000Genomes,ExAC,gnomAD
rs781525713	p.Thr722Ile	missense variant	-	NC_000018.10:g.27985044G>A	NCI-TCGA
rs781525713	p.Thr722Ile	missense variant	-	NC_000018.10:g.27985044G>A	ExAC,gnomAD
rs750975099	p.Thr722Ala	missense variant	-	NC_000018.10:g.27985045T>C	ExAC,gnomAD
COSM6083218	p.Gly723Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27985042C>A	NCI-TCGA Cosmic
rs151110746	p.Gly723Ser	missense variant	-	NC_000018.10:g.27985042C>T	ESP,ExAC,TOPMed,gnomAD
rs763843213	p.Ala724Thr	missense variant	-	NC_000018.10:g.27985039C>T	ExAC,gnomAD
rs1439874798	p.Ile725Val	missense variant	-	NC_000018.10:g.27985036T>C	gnomAD
rs1237046474	p.Ile726Thr	missense variant	-	NC_000018.10:g.27985032A>G	gnomAD
rs1280044418	p.Ile728Val	missense variant	-	NC_000018.10:g.27985027T>C	gnomAD
rs1231706166	p.Leu729Met	missense variant	-	NC_000018.10:g.27985024G>T	gnomAD
rs1270313904	p.Ile732Ser	missense variant	-	NC_000018.10:g.27985014A>C	TOPMed,gnomAD
rs762635467	p.Ile732Val	missense variant	-	NC_000018.10:g.27985015T>C	ExAC,gnomAD
rs752394774	p.Ile733Leu	missense variant	-	NC_000018.10:g.27985012T>G	ExAC,gnomAD
rs765163872	p.Ile733Met	missense variant	-	NC_000018.10:g.27985010G>C	ExAC,gnomAD
NCI-TCGA novel	p.Leu738Phe	missense variant	-	NC_000018.10:g.27983081G>A	NCI-TCGA
rs753513462	p.Val739Leu	missense variant	-	NC_000018.10:g.27983078C>A	NCI-TCGA
rs753513462	p.Val739Leu	missense variant	-	NC_000018.10:g.27983078C>A	ExAC,gnomAD
rs753513462	p.Val739Leu	missense variant	-	NC_000018.10:g.27983078C>G	ExAC,gnomAD
rs1471322766	p.Val739Gly	missense variant	-	NC_000018.10:g.27983077A>C	gnomAD
NCI-TCGA novel	p.Met741ValPheSerTerUnkUnk	frameshift	-	NC_000018.10:g.27983071_27983072AT>-	NCI-TCGA
rs534039382	p.Met741Ile	missense variant	-	NC_000018.10:g.27983070C>T	1000Genomes,ExAC,gnomAD
rs943756159	p.Phe742Ser	missense variant	-	NC_000018.10:g.27983068A>G	gnomAD
rs760591904	p.Val743Ala	missense variant	-	NC_000018.10:g.27983065A>G	ExAC,gnomAD
rs1188062661	p.Val744Ile	missense variant	-	NC_000018.10:g.27983063C>T	TOPMed
rs1443969148	p.Trp745Leu	missense variant	-	NC_000018.10:g.27983059C>A	TOPMed
rs1377836480	p.Lys747Glu	missense variant	-	NC_000018.10:g.27983054T>C	gnomAD
rs762994164	p.Arg748His	missense variant	-	NC_000018.10:g.27983050C>T	ExAC,TOPMed,gnomAD
rs199937130	p.Arg748Cys	missense variant	-	NC_000018.10:g.27983051G>A	ExAC,TOPMed,gnomAD
rs762994164	p.Arg748His	missense variant	-	NC_000018.10:g.27983050C>T	NCI-TCGA,NCI-TCGA Cosmic
rs373060189	p.Arg749Gln	missense variant	-	NC_000018.10:g.27983047C>T	ESP,ExAC,TOPMed,gnomAD
rs775708988	p.Arg749Trp	missense variant	-	NC_000018.10:g.27983048G>A	ExAC,TOPMed,gnomAD
rs775708988	p.Arg749Trp	missense variant	-	NC_000018.10:g.27983048G>A	NCI-TCGA,NCI-TCGA Cosmic
rs879079313	p.Asp750Gly	missense variant	-	NC_000018.10:g.27983044T>C	TOPMed,gnomAD
rs746246698	p.Lys751Arg	missense variant	-	NC_000018.10:g.27983041T>C	ExAC,TOPMed,gnomAD
rs771312999	p.Arg753Cys	missense variant	-	NC_000018.10:g.27983036G>A	ExAC,TOPMed,gnomAD
rs771312999	p.Arg753Cys	missense variant	-	NC_000018.10:g.27983036G>A	NCI-TCGA
rs747560192	p.Arg753His	missense variant	-	NC_000018.10:g.27983035C>T	ExAC,gnomAD
rs771312999	p.Arg753Ser	missense variant	-	NC_000018.10:g.27983036G>T	ExAC,TOPMed,gnomAD
rs778402718	p.Ala755Thr	missense variant	-	NC_000018.10:g.27983030C>T	ExAC,gnomAD
rs747621903	p.Lys756Asn	missense variant	-	NC_000018.10:g.27983025T>A	ExAC,gnomAD
rs142999960	p.Gln757Arg	missense variant	-	NC_000018.10:g.27983023T>C	ESP,ExAC,gnomAD
rs753519915	p.Pro762Ser	missense variant	-	NC_000018.10:g.27983009G>A	ExAC,gnomAD
NCI-TCGA novel	p.Asp764Tyr	missense variant	-	NC_000018.10:g.27983003C>A	NCI-TCGA
COSM6083219	p.Asp765Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27983000C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Asp768Glu	missense variant	-	NC_000018.10:g.27982989A>C	NCI-TCGA
rs766157846	p.Asp768Tyr	missense variant	-	NC_000018.10:g.27982991C>A	ExAC,gnomAD
NCI-TCGA novel	p.Ile770Val	missense variant	-	NC_000018.10:g.27982985T>C	NCI-TCGA
rs1467594732	p.Glu780Gly	missense variant	-	NC_000018.10:g.27982954T>C	gnomAD
rs1419936790	p.Asp784Asn	missense variant	-	NC_000018.10:g.27963521C>T	gnomAD
NCI-TCGA novel	p.Ser788Cys	missense variant	-	NC_000018.10:g.27963509T>A	NCI-TCGA
rs150933422	p.Thr795Pro	missense variant	-	NC_000018.10:g.27963488T>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1277458415	p.Val796Ala	missense variant	-	NC_000018.10:g.27963484A>G	TOPMed
NCI-TCGA novel	p.Ile801Asn	missense variant	-	NC_000018.10:g.27963469A>T	NCI-TCGA
rs375175765	p.Ile801Met	missense variant	-	NC_000018.10:g.27963468G>C	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Lys802Thr	missense variant	-	NC_000018.10:g.27963466T>G	NCI-TCGA
rs1212946496	p.Lys802Arg	missense variant	-	NC_000018.10:g.27963466T>C	TOPMed
rs1001078493	p.Val804Met	missense variant	-	NC_000018.10:g.27963461C>T	TOPMed
COSM2808325	p.Arg807Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27963451C>T	NCI-TCGA Cosmic
COSM5608078	p.Arg807Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000018.10:g.27963452G>A	NCI-TCGA Cosmic
rs759639016	p.Arg808Ter	stop gained	-	NC_000018.10:g.27963449G>A	ExAC
rs1313840328	p.Arg808Gln	missense variant	-	NC_000018.10:g.27963448C>T	gnomAD
rs754029821	p.Met809Thr	missense variant	-	NC_000018.10:g.27963445A>G	ExAC,gnomAD
rs1357019333	p.Asp810Tyr	missense variant	-	NC_000018.10:g.27963443C>A	gnomAD
NCI-TCGA novel	p.Glu811Lys	missense variant	-	NC_000018.10:g.27963440C>T	NCI-TCGA
NCI-TCGA novel	p.Pro813His	missense variant	-	NC_000018.10:g.27963433G>T	NCI-TCGA
rs267605138	p.Ile814Met	missense variant	-	NC_000018.10:g.27963429G>C	TOPMed,gnomAD
rs199674217	p.Ile814Val	missense variant	-	NC_000018.10:g.27963431T>C	ExAC,gnomAD
rs1362233326	p.His815Tyr	missense variant	-	NC_000018.10:g.27963428G>A	TOPMed
rs761127424	p.His815Gln	missense variant	-	NC_000018.10:g.27963426G>T	ExAC,TOPMed,gnomAD
rs773655778	p.Ala816Thr	missense variant	-	NC_000018.10:g.27963425C>T	ExAC,TOPMed,gnomAD
rs1476143861	p.Glu817Lys	missense variant	-	NC_000018.10:g.27963422C>T	gnomAD
NCI-TCGA novel	p.Pro818His	missense variant	-	NC_000018.10:g.27963418G>T	NCI-TCGA
NCI-TCGA novel	p.Pro818Thr	missense variant	-	NC_000018.10:g.27963419G>T	NCI-TCGA
rs200230866	p.Pro818Leu	missense variant	-	NC_000018.10:g.27963418G>A	TOPMed
rs774895186	p.Gln819His	missense variant	-	NC_000018.10:g.27963414C>G	ExAC,gnomAD
rs768097198	p.Pro821Leu	missense variant	-	NC_000018.10:g.27963409G>A	ExAC,TOPMed,gnomAD
COSM6148974	p.Val822Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27963407C>A	NCI-TCGA Cosmic
rs779600795	p.Val822Ala	missense variant	-	NC_000018.10:g.27963406A>G	ExAC,gnomAD
NCI-TCGA novel	p.Arg823Leu	missense variant	-	NC_000018.10:g.27963403C>A	NCI-TCGA
rs199638301	p.Arg823Gln	missense variant	-	NC_000018.10:g.27963403C>T	ESP,ExAC,TOPMed,gnomAD
rs1277644544	p.Ala825Ser	missense variant	-	NC_000018.10:g.27963398C>A	gnomAD
rs1217385337	p.Ala825Val	missense variant	-	NC_000018.10:g.27963397G>A	gnomAD
rs1277644544	p.Ala825Thr	missense variant	-	NC_000018.10:g.27963398C>T	gnomAD
rs1302337851	p.Pro829Leu	missense variant	-	NC_000018.10:g.27963385G>A	TOPMed
rs1294310150	p.Pro829Ser	missense variant	-	NC_000018.10:g.27963386G>A	gnomAD
rs1376520105	p.Ile832Met	missense variant	-	NC_000018.10:g.27963375A>C	gnomAD
rs202236593	p.Gly833Glu	missense variant	-	NC_000018.10:g.27963373C>T	gnomAD
NCI-TCGA novel	p.Asp834ThrPheSerTerUnkUnk	frameshift	-	NC_000018.10:g.27963371C>-	NCI-TCGA
COSM4670852	p.Phe835Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27963366G>T	NCI-TCGA Cosmic
rs200254151	p.Asn837Ile	missense variant	-	NC_000018.10:g.27963361T>A	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu838Asp	missense variant	-	NC_000018.10:g.27963357C>A	NCI-TCGA
NCI-TCGA novel	p.Glu838Lys	missense variant	-	NC_000018.10:g.27963359C>T	NCI-TCGA
COSM6083221	p.Lys841Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27952352T>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ala842Ser	missense variant	-	NC_000018.10:g.27952350C>A	NCI-TCGA
NCI-TCGA novel	p.Ala842Pro	missense variant	-	NC_000018.10:g.27952350C>G	NCI-TCGA
rs370333144	p.Ala842Val	missense variant	-	NC_000018.10:g.27952349G>A	ESP,ExAC,TOPMed,gnomAD
rs1293562698	p.Ala842Thr	missense variant	-	NC_000018.10:g.27952350C>T	TOPMed
rs1354823437	p.Ala843Ser	missense variant	-	NC_000018.10:g.27952347C>A	gnomAD
rs2289664	p.Asn845Ser	missense variant	-	NC_000018.10:g.27952340T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs751881258	p.Asn845Tyr	missense variant	-	NC_000018.10:g.27952341T>A	ExAC,gnomAD
rs878963425	p.Pro850Ser	missense variant	-	NC_000018.10:g.27952326G>A	TOPMed
rs1312662447	p.Tyr852Ser	missense variant	-	NC_000018.10:g.27952319T>G	TOPMed
COSM473716	p.Leu856Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000018.10:g.27952307A>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Tyr860MetPheSerTerUnkUnk	frameshift	-	NC_000018.10:g.27952297G>-	NCI-TCGA
NCI-TCGA novel	p.Ser863Arg	missense variant	-	NC_000018.10:g.27952285A>T	NCI-TCGA
rs764766275	p.Ser863Cys	missense variant	-	NC_000018.10:g.27952287T>A	ExAC,gnomAD
rs200803866	p.Gly864Asp	missense variant	-	NC_000018.10:g.27952283C>T	ESP,ExAC,TOPMed,gnomAD
rs776296541	p.Thr866Ser	missense variant	-	NC_000018.10:g.27952277G>C	ExAC,TOPMed,gnomAD
rs776296541	p.Thr866Asn	missense variant	-	NC_000018.10:g.27952277G>T	ExAC,TOPMed,gnomAD
rs896948558	p.Ala867Pro	missense variant	-	NC_000018.10:g.27952275C>G	TOPMed,gnomAD
NCI-TCGA novel	p.Gly868Val	missense variant	-	NC_000018.10:g.27952271C>A	NCI-TCGA
NCI-TCGA novel	p.Leu870Ter	stop gained	-	NC_000018.10:g.27952265A>T	NCI-TCGA
NCI-TCGA novel	p.Leu873Pro	missense variant	-	NC_000018.10:g.27952256A>G	NCI-TCGA
COSM3890839	p.Leu873Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27952257G>A	NCI-TCGA Cosmic
rs1379928255	p.Leu873Val	missense variant	-	NC_000018.10:g.27952257G>C	TOPMed,gnomAD
rs773118735	p.Asn874Lys	missense variant	-	NC_000018.10:g.27952252A>C	ExAC,gnomAD
NCI-TCGA novel	p.Ser876Ter	stop gained	-	NC_000018.10:g.27952247G>T	NCI-TCGA
NCI-TCGA novel	p.Ser877Arg	missense variant	-	NC_000018.10:g.27952245T>G	NCI-TCGA
rs771762304	p.Ser877Gly	missense variant	-	NC_000018.10:g.27952245T>C	ExAC,gnomAD
rs138164198	p.Ser877Thr	missense variant	-	NC_000018.10:g.27952244C>G	ESP,ExAC,TOPMed,gnomAD
rs138164198	p.Ser877Asn	missense variant	-	NC_000018.10:g.27952244C>T	ESP,ExAC,TOPMed,gnomAD
COSM987322	p.Ser878Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27952241C>A	NCI-TCGA Cosmic
rs1198222564	p.Gly879Asp	missense variant	-	NC_000018.10:g.27952238C>T	gnomAD
rs199787442	p.Gly880Ala	missense variant	-	NC_000018.10:g.27952235C>G	ExAC,TOPMed,gnomAD
rs371258872	p.Gly880Ser	missense variant	-	NC_000018.10:g.27952236C>T	ESP,TOPMed
rs756289185	p.Glu881Asp	missense variant	-	NC_000018.10:g.27952231C>A	ExAC,gnomAD
rs879088485	p.Glu881Lys	missense variant	-	NC_000018.10:g.27952233C>T	TOPMed
rs377612781	p.Asp883His	missense variant	-	NC_000018.10:g.27952227C>G	ESP,ExAC,TOPMed,gnomAD
rs377612781	p.Asp883Asn	missense variant	-	NC_000018.10:g.27952227C>T	ESP,ExAC,TOPMed,gnomAD
rs1488202424	p.Tyr884Cys	missense variant	-	NC_000018.10:g.27952223T>C	gnomAD
rs201334347	p.Asn888Lys	missense variant	-	NC_000018.10:g.27952210G>T	ESP,ExAC,TOPMed,gnomAD
rs200373316	p.Asp889Asn	missense variant	-	NC_000018.10:g.27952209C>T	ESP,ExAC,TOPMed,gnomAD
rs199657884	p.Asp889Gly	missense variant	-	NC_000018.10:g.27952208T>C	gnomAD
rs764584049	p.Gly891Arg	missense variant	-	NC_000018.10:g.27952203C>T	ExAC,gnomAD
rs758658207	p.Pro892Leu	missense variant	-	NC_000018.10:g.27952199G>A	ExAC,TOPMed,gnomAD
rs1328130862	p.Pro892Ser	missense variant	-	NC_000018.10:g.27952200G>A	gnomAD
rs753251005	p.Arg893Trp	missense variant	-	NC_000018.10:g.27952197G>A	ExAC,gnomAD
rs201294768	p.Arg893Gln	missense variant	-	NC_000018.10:g.27952196C>T	1000Genomes,gnomAD
COSM6083222	p.Phe894Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27952193A>G	NCI-TCGA Cosmic
COSM1324651	p.Phe894Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27952192G>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Lys895Asn	missense variant	-	NC_000018.10:g.27952189C>A	NCI-TCGA
COSM4071664	p.Leu897Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27952185G>C	NCI-TCGA Cosmic
COSM4071663	p.Leu897His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000018.10:g.27952184A>T	NCI-TCGA Cosmic
rs776060409	p.Met900Val	missense variant	-	NC_000018.10:g.27952176T>C	ExAC,gnomAD
NCI-TCGA novel	p.Tyr901Cys	missense variant	-	NC_000018.10:g.27952172T>C	NCI-TCGA
rs765791790	p.Asp905Asn	missense variant	-	NC_000018.10:g.27952161C>T	ExAC,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0001418	Adenocarcinoma	group	BEFREE
C0002395	Alzheimer's Disease	disease	LHGDN
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE;LHGDN
C0006142	Malignant neoplasm of breast	disease	BEFREE;CTD_human
C0007102	Malignant tumor of colon	disease	BEFREE
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE
C0007193	Cardiomyopathy, Dilated	group	LHGDN
C0009375	Colonic Neoplasms	group	LHGDN
C0011881	Diabetic Nephropathy	disease	BEFREE
C0017636	Glioblastoma	disease	BEFREE
C0017638	Glioma	disease	BEFREE;LHGDN
C0019693	HIV Infections	group	BEFREE
C0021704	Intelligence	phenotype	GWASCAT
C0023269	leiomyosarcoma	disease	BEFREE
C0023467	Leukemia, Myelocytic, Acute	disease	BEFREE
C0023473	Myeloid Leukemia, Chronic	disease	BEFREE
C0024623	Malignant neoplasm of stomach	disease	CTD_human
C0025202	melanoma	disease	BEFREE;LHGDN
C0026764	Multiple Myeloma	disease	BEFREE
C0027626	Neoplasm Invasiveness	phenotype	CTD_human
C0027627	Neoplasm Metastasis	phenotype	BEFREE;CTD_human
C0027746	Nerve Degeneration	phenotype	CTD_human
C0028754	Obesity	disease	BEFREE
C0028768	Obsessive-Compulsive Disorder	disease	BEFREE
C0029408	Degenerative polyarthritis	disease	BEFREE
C0029463	Osteosarcoma	disease	BEFREE
C0033578	Prostatic Neoplasms	group	LHGDN
C0033822	Pseudomyxoma Peritonei	disease	LHGDN
C0038220	Status Epilepticus	disease	CTD_human
C0038356	Stomach Neoplasms	group	CTD_human;LHGDN
C0040517	Gilles de la Tourette syndrome	disease	BEFREE
C0151744	Myocardial Ischemia	disease	CTD_human
C0152013	Adenocarcinoma of lung (disorder)	disease	BEFREE
C0158646	Cleft palate with cleft lip	disease	BEFREE
C0175697	Van der Woude syndrome	disease	BEFREE
C0178874	Tumor Progression	phenotype	BEFREE
C0220620	Gastrointestinal Carcinoid Tumor	disease	BEFREE
C0220650	Metastatic malignant neoplasm to brain	disease	BEFREE
C0235874	Disease Exacerbation	phenotype	CTD_human
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0268621	Hepatic methionine adenosyltransferase deficiency	disease	BEFREE
C0270823	Petit mal status	disease	CTD_human
C0311335	Grand Mal Status Epilepticus	disease	CTD_human
C0334276	Adenocarcinoma in Situ	phenotype	BEFREE
C0349788	Arrhythmogenic Right Ventricular Dysplasia	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0393734	Complex Partial Status Epilepticus	disease	CTD_human
C0525045	Mood Disorders	group	BEFREE
C0585442	Osteosarcoma of bone	disease	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE;CTD_human
C0684249	Carcinoma of lung	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0751522	Status Epilepticus, Subclinical	disease	CTD_human
C0751523	Non-Convulsive Status Epilepticus	disease	CTD_human
C0751524	Simple Partial Status Epilepticus	disease	CTD_human
C0812413	Malignant Pleural Mesothelioma	disease	BEFREE
C0878544	Cardiomyopathies	group	BEFREE
C1168401	Squamous cell carcinoma of the head and neck	disease	BEFREE
C1176475	Ductal Carcinoma	disease	LHGDN
C1257931	Mammary Neoplasms, Human	group	CTD_human
C1302401	Adenoma of large intestine	disease	BEFREE
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1458155	Mammary Neoplasms	group	BEFREE;CTD_human
C1510586	Autism Spectrum Disorders	disease	BEFREE
C1704373	Compulsive Personality Disorder	disease	BEFREE
C1708349	Hereditary Diffuse Gastric Cancer	disease	CTD_human
C1956346	Coronary Artery Disease	disease	BEFREE
C2239176	Liver carcinoma	disease	LHGDN

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005509	calcium ion binding	ISS
GO:0005509	calcium ion binding	IBA
GO:0005515	protein binding	IPI
GO:0008013	beta-catenin binding	TAS
GO:0008013	beta-catenin binding	IPI
GO:0008092	cytoskeletal protein binding	IBA
GO:0019901	protein kinase binding	IEA
GO:0019903	protein phosphatase binding	IEA
GO:0042803	protein homodimerization activity	IBA
GO:0045294	alpha-catenin binding	IPI
GO:0045295	gamma-catenin binding	IPI
GO:0045296	cadherin binding	IBA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000902	cell morphogenesis	IBA
GO:0007043	cell-cell junction assembly	IBA
GO:0007155	cell adhesion	TAS
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	IBA
GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA
GO:0007275	multicellular organism development	IBA
GO:0007416	synapse assembly	IBA
GO:0007420	brain development	IBA
GO:0010001	glial cell differentiation	ISS
GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
GO:0016477	cell migration	IEA
GO:0021987	cerebral cortex development	IEA
GO:0034332	adherens junction organization	IBA
GO:0034332	adherens junction organization	TAS
GO:0043410	positive regulation of MAPK cascade	IEA
GO:0043687	post-translational protein modification	TAS
GO:0044267	cellular protein metabolic process	TAS
GO:0044331	cell-cell adhesion mediated by cadherin	ISS
GO:0044331	cell-cell adhesion mediated by cadherin	IBA
GO:0048514	blood vessel morphogenesis	IBA
GO:0048854	brain morphogenesis	IEA
GO:0048872	homeostasis of number of cells	IEA
GO:0050770	regulation of axonogenesis	IBA
GO:0051146	striated muscle cell differentiation	IEA
GO:0051149	positive regulation of muscle cell differentiation	TAS
GO:0051966	regulation of synaptic transmission, glutamatergic	IBA
GO:0060019	radial glial cell differentiation	IEA
GO:0060563	neuroepithelial cell differentiation	IEA
GO:0070445	regulation of oligodendrocyte progenitor proliferation	IEA
GO:0072659	protein localization to plasma membrane	IEA
GO:0090090	negative regulation of canonical Wnt signaling pathway	IEA
GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly	IEA
GO:0097150	neuronal stem cell population maintenance	ISS
GO:0098609	cell-cell adhesion	ISS
GO:0098609	cell-cell adhesion	IBA
GO:1902897	regulation of postsynaptic density protein 95 clustering	IEA
GO:2000809	positive regulation of synaptic vesicle clustering	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005737	cytoplasm	IBA
GO:0005737	cytoplasm	IDA
GO:0005788	endoplasmic reticulum lumen	TAS
GO:0005886	plasma membrane	IBA
GO:0005886	plasma membrane	IDA
GO:0005886	plasma membrane	TAS
GO:0005887	integral component of plasma membrane	ISS
GO:0005911	cell-cell junction	IDA
GO:0005912	adherens junction	IDA
GO:0005912	adherens junction	IBA
GO:0005916	fascia adherens	IEA
GO:0005925	focal adhesion	HDA
GO:0009986	cell surface	ISS
GO:0009986	cell surface	IBA
GO:0014069	postsynaptic density	IBA
GO:0014704	intercalated disc	ISS
GO:0014704	intercalated disc	IBA
GO:0016323	basolateral plasma membrane	IEA
GO:0016324	apical plasma membrane	IEA
GO:0016342	catenin complex	IBA
GO:0016342	catenin complex	IDA
GO:0030027	lamellipodium	IBA
GO:0030027	lamellipodium	IDA
GO:0030054	cell junction	IDA
GO:0042383	sarcolemma	IEA
GO:0043005	neuron projection	IBA
GO:0044853	plasma membrane raft	IEA
GO:0045177	apical part of cell	IBA
GO:0045202	synapse	IBA
GO:0062023	collagen-containing extracellular matrix	HDA
GO:0099059	integral component of presynaptic active zone membrane	IBA
GO:0099060	integral component of postsynaptic specialization membrane	IBA
GO:0030864	cortical actin cytoskeleton	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1500931	Cell-Cell communication	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-418990	Adherens junctions interactions	TAS
R-HSA-421270	Cell-cell junction organization	TAS
R-HSA-446728	Cell junction organization	TAS
R-HSA-525793	Myogenesis	TAS
R-HSA-525793	Myogenesis	IEA
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CDH2 protein	21705713
D015655	1-Methyl-4-phenylpyridinium	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDH2 mRNA]	12710931
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]	24997338
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of CDH2 protein]	24997338
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in decreased expression of CDH2 protein]	27474067
C120227	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CDH2 protein]	28163245
C120227	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Testosterone results in decreased phosphorylation of CDH2 protein]	28163245
C120227	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
C094210	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CDH2 mRNA	16580782
C094210	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	CDH2 protein affects the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CTNNB1 mRNA]	16580782
C094210	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	CDH2 protein affects the susceptibility to 2,2'-(hydroxynitrosohydrazono)bis-ethanamine	16580782
C063002	2,3-dimethoxy-1,4-naphthoquinone	2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CDH2 mRNA	17547211
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of CDH2 mRNA	29108245
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of CDH2 protein	29108245
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	TLN1 protein inhibits the reaction [2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of CDH2 mRNA]	29108245
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	TLN1 protein inhibits the reaction [2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of CDH2 protein]	29108245
C121479	2,4-dihydroxybenzophenone	2,4-dihydroxybenzophenone results in increased expression of CDH2 protein	27145024
C121479	2,4-dihydroxybenzophenone	Fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of CDH2 protein]	27145024
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene affects the expression of CDH2 mRNA	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]	24997338
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of CDH2 protein]	24997338
C519132	2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride	2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDH2 protein]	22869556
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]	28844962
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CDH2 protein]	28844962
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CDH2 protein]	28844962
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	PKM protein promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	WP1066 inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]	28284859
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of CDH2 protein	25725129
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	HMGA2 protein inhibits the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of CDH2 protein]	25725129
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	MIR33B mRNA affects the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of CDH2 protein]	25725129
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of CDH2 mRNA	21983209; 24140754;
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of CDH2 mRNA	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
C032538	4-cresol	4-cresol affects the localization of CDH2 protein	23466501
C032538	4-cresol	4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]	23466501
C032538	4-cresol	Go 6976 inhibits the reaction [4-cresol affects the localization of CDH2 protein]	23466501
C032538	4-cresol	Go 6976 inhibits the reaction [4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]]	23466501
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CDH2 mRNA	12419474
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CDH2 protein	30236600
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of CDH2 protein	27145024
C105260	4-tert-octylphenol	Fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of CDH2 protein]	27145024
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of CDH2 protein	15082077
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased localization of CDH2 protein	15082077
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDH2 mRNA	19150397
D000082	Acetaminophen	Acetaminophen affects the expression of CDH2 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]	28284859
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [DDT results in increased expression of CDH2 mRNA]	24820114
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
D000181	Acrylonitrile	Acrylonitrile results in increased expression of CDH2 protein	30236600
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CDH2 mRNA	19770486
D019386	Alendronate	Alendronate affects the expression of CDH2 mRNA	16079270
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of CDH2 mRNA	20409345
C100057	ametryne	ametryne results in increased expression of CDH2 mRNA	26310382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CDH2 mRNA	16483693
C030419	andrographolide	andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]	31128153
C030419	andrographolide	IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]]	31128153
C545357	antroquinonol	antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDH2 protein]	25656647
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of CDH2 protein	29396848
C015001	arsenite	arsenite results in increased methylation of CDH2 promoter	23974009
C015001	arsenite	arsenite results in increased expression of CDH2 protein	21344382
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in decreased expression of CDH2 mRNA	29523930
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [mono-(2-ethylhexyl)phthalate affects the localization of CDH2 protein]	29940330
D001374	Azacitidine	Azacitidine results in increased expression of CDH2 mRNA	18037191
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of CDH2 mRNA	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CDH2 mRNA	19770486; 23735875;
D001599	Berberine	Berberine results in decreased expression of CDH2 mRNA	26478571
C004541	biochanin A	biochanin A results in decreased expression of CDH2 mRNA	12111696
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of CDH2 protein	28808208
C543008	bis(4-hydroxyphenyl)sulfone	Fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CDH2 protein]	28808208
C006780	bisphenol A	bisphenol A results in increased methylation of CDH2 intron	30906313
C006780	bisphenol A	bisphenol A results in increased expression of CDH2 mRNA	26364221
C006780	bisphenol A	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]	24997338
C006780	bisphenol A	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]	24997338
C006780	bisphenol A	3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]	28844962
C006780	bisphenol A	bisphenol A results in decreased expression of and affects the localization of CDH2 protein	24532171
C006780	bisphenol A	bisphenol A results in decreased expression of CDH2 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of CDH2 mRNA	24997338; 26363213;
C006780	bisphenol A	bisphenol A results in increased expression of CDH2 protein	24997338; 26363213; 28808208; 28844962; 30611077;
C006780	bisphenol A	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]	28808208; 28844962;
C006780	bisphenol A	bisphenol A affects the expression of CDH2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of and affects the localization of CDH2 protein	19497385
C006780	bisphenol A	bisphenol A results in decreased expression of CDH2 protein	15082077
C006780	bisphenol A	bisphenol A results in increased expression of CDH2 mRNA	25181051; 28355696; 29323181; 30816183;
C006780	bisphenol A	bisphenol A results in increased expression of CDH2 protein	19782717; 28355696;
C006780	bisphenol A	bisphenol A results in increased methylation of CDH2 gene	28505145
C000611646	bisphenol F	bisphenol F results in increased expression of CDH2 protein	28808208
C000611646	bisphenol F	Fulvestrant inhibits the reaction [bisphenol F results in increased expression of CDH2 protein]	28808208
D002104	Cadmium	Cadmium results in decreased expression of CDH2 protein	26424772
D002104	Cadmium	flavocoxid inhibits the reaction [Cadmium results in decreased expression of CDH2 protein]	26424772
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of CDH2 protein	24532171
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CDH2 mRNA	27224422
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CDH2 protein	27224422
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CDH2 mRNA	24982889
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CDH2 protein	26424772
D019256	Cadmium Chloride	flavocoxid inhibits the reaction [Cadmium Chloride results in decreased expression of CDH2 protein]	26424772
D019256	Cadmium Chloride	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
D019256	Cadmium Chloride	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CDH2 protein	15618353
D019256	Cadmium Chloride	Cadmium Chloride results in increased cleavage of CDH2 protein	23876460
D019256	Cadmium Chloride	N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of CDH2 protein]	15618353
D019256	Cadmium Chloride	NCSTN protein affects the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
D019256	Cadmium Chloride	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
D019256	Cadmium Chloride	U 0126 inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
D019256	Cadmium Chloride	MAP2K1 protein mutant form promotes the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
D002112	Calcifediol	Calcifediol deficiency results in decreased expression of CDH2 protein	26210580
D002117	Calcitriol	[Calcitriol co-treated with VDR protein] results in increased expression of CDH2 protein	26210580
C459604	candoxin	candoxin results in increased expression of CDH2 mRNA	16309724
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of CDH2 protein	27481218
D020111	Chlorodiphenyl (54% Chlorine)	MIR30D mRNA inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of CDH2 protein]	27481218
D002737	Chloroprene	Chloroprene results in decreased expression of CDH2 mRNA	23125180
D002738	Chloroquine	Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 mRNA]	30053495
D002738	Chloroquine	Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 protein]	30053495
D002762	Cholecalciferol	Cholecalciferol results in increased expression of CDH2 mRNA	17170073
C043561	chrysin	chrysin results in decreased expression of CDH2 protein	30578657
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of CDH2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of CDH2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of CDH2 protein	21618587
D002994	Clofibrate	Clofibrate results in increased expression of CDH2 mRNA	17585979
D003035	Cobalt	[tungsten carbide binds to Cobalt] which results in increased expression of CDH2 mRNA	20105288
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CDH2 mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CDH2 mRNA	20105288
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of CDH2 mRNA	24690739
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CDH2 mRNA	15467011
D003345	Corticosterone	[Corticosterone results in increased phosphorylation of NDRG1 protein] which results in increased expression of and results in increased localization of CDH2 protein	21655274
D003474	Curcumin	Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]	26191140
D003474	Curcumin	Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]	26191140
D003520	Cyclophosphamide	Cyclophosphamide affects the expression of CDH2 mRNA	10859244
D016572	Cyclosporine	Cyclosporine results in decreased expression of CDH2 mRNA	20106945; 22147139; 25562108;
D003634	DDT	Acetylcysteine inhibits the reaction [DDT results in increased expression of CDH2 mRNA]	24820114
D003634	DDT	DDT results in increased expression of CDH2 mRNA	24820114
D003634	DDT	INCB018424 inhibits the reaction [DDT results in increased expression of CDH2 mRNA]	24820114
D003634	DDT	WP1066 inhibits the reaction [DDT results in increased expression of CDH2 mRNA]	24820114
D000077209	Decitabine	Decitabine results in decreased expression of CDH2 mRNA	30125549
D000077209	Decitabine	Decitabine results in decreased expression of CDH2 protein	30125549
D000077209	Decitabine	Decitabine results in increased expression of CDH2 mRNA	16367923
D000077209	Decitabine	Decitabine affects the methylation of CDH2 promoter	17959753
C107676	deguelin	deguelin results in decreased expression of CDH2 protein	22986522
C017185	delphinidin	delphinidin results in decreased expression of CDH2 protein	29451351
C040424	destruxin B	destruxin B results in decreased expression of CDH2 protein	24434019
C040424	destruxin B	Sorafenib promotes the reaction [destruxin B results in decreased expression of CDH2 protein]	24434019
D003907	Dexamethasone	Dexamethasone results in increased expression of CDH2 mRNA	28453788
D003907	Dexamethasone	Dexamethasone results in decreased expression of CDH2 mRNA	25047013
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of CDH2 mRNA	12205029
D003913	Dextroamphetamine	SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of CDH2 mRNA]	12205029
C041517	dibenzo(a,l)pyrene	[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of CDH2 mRNA	17690111
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CDH2 mRNA	17361019; 21266533;
D003993	Dibutyl Phthalate	Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 mRNA]	30053495
D003993	Dibutyl Phthalate	Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 protein]	30053495
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CDH2 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CDH2 mRNA	21266533; 30053495;
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CDH2 protein	30053495
D003993	Dibutyl Phthalate	Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of CDH2 mRNA]	30053495
D003993	Dibutyl Phthalate	Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of CDH2 protein]	30053495
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of CDH2 protein	23501609
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased expression of CDH2 mRNA	23501609
C000944	dicrotophos	dicrotophos results in decreased expression of CDH2 mRNA	28302478
C026398	dictamnine	[dictamnine co-treated with Oxygen deficiency] results in decreased expression of CDH2 protein	30266538
C026398	dictamnine	dictamnine promotes the reaction [HIF1A protein affects the expression of CDH2 mRNA]	30266538
C026398	dictamnine	dictamnine promotes the reaction [HIF1A protein affects the expression of CDH2 protein]	30266538
C026398	dictamnine	dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH2 mRNA]	30266538
C026398	dictamnine	dictamnine promotes the reaction [SNAI2 protein affects the expression of CDH2 protein]	30266538
C026398	dictamnine	dictamnine results in decreased expression of CDH2 protein	30266538
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of CDH2 mRNA	26924002
D004026	Dieldrin	Dieldrin results in decreased expression of CDH2 protein	15082077
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of CDH2 mRNA	28085963
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of CDH2 mRNA	20920545
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of CDH2 protein	16678996; 29940330;
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of CDH2 protein	21163286
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased expression of CDH2 protein	21163286
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of CDH2 gene	21163286
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of CDH2 mRNA	25242112
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of CDH2 mRNA	26924002
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of CDH2 mRNA	24690739
C516138	dorsomorphin	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
D004317	Doxorubicin	Doxorubicin affects the expression of CDH2 protein	29385562
D004317	Doxorubicin	Doxorubicin results in decreased expression of CDH2 mRNA	29803840
D060766	Drinking Water	Drinking Water results in increased expression of CDH2 mRNA	19444861
D004726	Endosulfan	Endosulfan results in decreased expression of CDH2 mRNA	29391264
C118739	entinostat	entinostat results in decreased expression of CDH2 mRNA	26272509
C118739	entinostat	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
D004958	Estradiol	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of CDH2 protein]	24997338
D004958	Estradiol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of CDH2 protein]	24997338
D004958	Estradiol	3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CDH2 protein]	28844962
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in increased expression of CDH2 mRNA	30165855
D004958	Estradiol	Estradiol results in increased expression of CDH2 mRNA	24997338
D004958	Estradiol	Estradiol results in increased expression of CDH2 protein	24997338; 27539251; 28844962;
D004958	Estradiol	Fulvestrant inhibits the reaction [Estradiol results in increased expression of CDH2 protein]	27539251; 28844962;
D004958	Estradiol	Estradiol promotes the reaction [FSHB protein results in increased expression of CDH2 mRNA]	8977383
D004967	Estrogens	Estrogens affects the expression of CDH2 mRNA	15473135
D000431	Ethanol	Ethanol results in increased expression of CDH2 mRNA	29361514
D000431	Ethanol	Ethanol results in increased expression of CDH2 mRNA	28919490
D000431	Ethanol	Ethanol results in increased expression of CDH2 protein	28919490
D000431	Ethanol	Ethanol affects the splicing of CDH2 mRNA	30319688
D000431	Ethanol	Ethanol results in increased expression of CDH2 mRNA	30319688
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDH2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CDH2 mRNA	16079270
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CDH2 mRNA	15834898
C032773	ethyl caffeate	ethyl caffeate affects the expression of CDH2 protein	24892518
D017313	Fenretinide	Fenretinide results in increased expression of CDH2 mRNA	28973697
C544478	flavocoxid	flavocoxid inhibits the reaction [Cadmium Chloride results in decreased expression of CDH2 protein]	26424772
C544478	flavocoxid	flavocoxid inhibits the reaction [Cadmium results in decreased expression of CDH2 protein]	26424772
C018945	flubendazole	flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]	30075109
C108339	fludioxonil	fludioxonil results in increased expression of CDH2 protein	27539251
C108339	fludioxonil	Fulvestrant inhibits the reaction [fludioxonil results in increased expression of CDH2 protein]	27539251
D005557	Formaldehyde	Formaldehyde results in increased expression of CDH2 protein	30236600
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of CDH2 protein]	27145024
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]	28284859
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of CDH2 protein]	27145024
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased expression of CDH2 protein]	28808208
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]	28808208; 28844962;
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bisphenol F results in increased expression of CDH2 protein]	28808208
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Estradiol results in increased expression of CDH2 protein]	27539251; 28844962;
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [fludioxonil results in increased expression of CDH2 protein]	27539251
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Triclosan results in increased expression of CDH2 protein]	28844962
D019833	Genistein	Genistein results in increased expression of CDH2 protein	16149052
D005897	Glafenine	Glafenine results in decreased expression of CDH2 mRNA	24136188
C055124	glaucocalyxin A	glaucocalyxin A inhibits the reaction [TGFB1 protein results in increased expression of CDH2 mRNA]	31059706
C055124	glaucocalyxin A	glaucocalyxin A inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]	31059706
C055124	glaucocalyxin A	glaucocalyxin A results in decreased expression of CDH2 mRNA	31059706
C055124	glaucocalyxin A	glaucocalyxin A results in decreased expression of CDH2 protein	31059706
C010974	glyphosate	[Surface-Active Agents co-treated with glyphosate] results in increased expression of CDH2 mRNA	22467014
C081021	Go 6976	Go 6976 inhibits the reaction [4-cresol affects the localization of CDH2 protein]	23466501
C081021	Go 6976	Go 6976 inhibits the reaction [4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]]	23466501
D006072	Gossypol	Gossypol results in decreased expression of CDH2 protein	15082077
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of CDH2 mRNA	12419474
C014290	hydroxyflutamide	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CDH2 protein]	28163245
C014290	hydroxyflutamide	hydroxyflutamide results in decreased phosphorylation of CDH2 protein	28163245
C014290	hydroxyflutamide	Wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CDH2 protein]	28163245
C082359	imidacloprid	imidacloprid results in decreased expression of CDH2 mRNA	27792329
C082359	imidacloprid	imidacloprid results in decreased expression of CDH2 protein	27792329
C540383	INCB018424	INCB018424 inhibits the reaction [DDT results in increased expression of CDH2 mRNA]	24820114
C545476	incobotulinumtoxinA	incobotulinumtoxinA results in decreased expression of CDH2 mRNA	29522793
C027185	indirubin	indirubin results in decreased expression of CDH2 mRNA	15056799
C005059	isoprene	isoprene results in increased expression of CDH2 protein	30236600
D007545	Isoproterenol	Isoproterenol results in decreased expression of CDH2 mRNA	21335049
C057531	jasplakinolide	jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH2 protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH2 protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH2 protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH2 protein]	20388789
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of CDH2 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of CDH2 mRNA	27392435
D000077341	Lapatinib	[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein	26643609
D000077341	Lapatinib	Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein]	26643609
C008261	lead acetate	lead acetate results in decreased expression of CDH2 protein	10814846
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of CDH2 mRNA	23527032
D047311	Luteolin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in decreased expression of CDH2 protein]	27474067
D047311	Luteolin	Luteolin results in decreased expression of CDH2 protein	27474067
D008463	Mebendazole	Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]	30075109
C011907	melamine	melamine results in decreased expression of CDH2 protein	30055240
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of CDH2 mRNA	21126564
D008694	Methamphetamine	Methamphetamine results in decreased expression of CDH2 mRNA	29802913
D008701	Methapyrilene	Methapyrilene results in decreased expression of CDH2 mRNA	30467583
D008748	Methylcholanthrene	[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of CDH2 protein	21163286
D008748	Methylcholanthrene	[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased expression of CDH2 protein	21163286
D008748	Methylcholanthrene	[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of CDH2 gene	21163286
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CDH2 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of CDH2 mRNA	26011545
D008770	Methylnitrosourea	[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 mRNA	25164625
D008770	Methylnitrosourea	[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 protein	25164625
D008770	Methylnitrosourea	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 mRNA]	25164625
D008770	Methylnitrosourea	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 protein]	25164625
C016599	mono-(2-ethylhexyl)phthalate	[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [mono-(2-ethylhexyl)phthalate affects the localization of CDH2 protein]	29940330
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of and affects the localization of CDH2 protein	29940330
C028577	monobutyl phthalate	monobutyl phthalate results in decreased expression of CDH2 protein	26922907
C020300	monomethylarsonic acid	monomethylarsonic acid results in increased expression of CDH2 mRNA	17481689
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of CDH2 mRNA	26924002
C057451	morusin	morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDH2 protein]	28108223
C523799	MRK 003	CDH2 results in increased susceptibility to MRK 003	19903844
C001020	N(6),N(6)-dimethyladenine	N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of CDH2 protein]	15618353
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of CDH2 mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of CDH2 mRNA	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of CDH2 mRNA	19812364
C051752	nefazodone	nefazodone results in decreased expression of CDH2 mRNA	24136188
D009534	Niclosamide	Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein]	26643609
C012655	nimesulide	nimesulide results in decreased expression of CDH2 mRNA	24136188
D009588	Nitrogen Mustard Compounds	Nitrogen Mustard Compounds results in decreased expression of CDH2 mRNA	18572855
D009588	Nitrogen Mustard Compounds	Nitrogen Mustard Compounds results in decreased expression of CDH2 protein	18572855
D009588	Nitrogen Mustard Compounds	Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 mRNA]	18572855
D009588	Nitrogen Mustard Compounds	Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 protein]	18572855
D018817	N-Methyl-3,4-methylenedioxyamphetamine	N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CDH2 mRNA	20188158
D018817	N-Methyl-3,4-methylenedioxyamphetamine	N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CDH2 protein	23747752
C047330	N-methylisoindigotin	N-methylisoindigotin results in decreased expression of CDH2 mRNA	26887594
C047330	N-methylisoindigotin	N-methylisoindigotin results in decreased expression of CDH2 protein	26887594
C000623013	NMS-873	NMS-873 results in decreased expression of CDH2 protein	29693262
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
C025256	nonylphenol	nonylphenol analog results in decreased expression of CDH2 mRNA	25242005
C025256	nonylphenol	nonylphenol analog results in increased expression of CDH2 mRNA	25242005
C025256	nonylphenol	nonylphenol affects the expression of CDH2 mRNA	27832966
C025256	nonylphenol	nonylphenol results in decreased expression of CDH2 protein	27832966
C069741	norcantharidin	norcantharidin results in decreased expression of CDH2 protein	15711181
D009675	Novobiocin	Novobiocin results in decreased expression of CDH2 protein	11853877
C011959	oridonin	oridonin inhibits the reaction [TGFB1 protein results in decreased expression of CDH2 mRNA]	30243739
C011959	oridonin	oridonin inhibits the reaction [TGFB1 protein results in decreased expression of CDH2 protein]	30243739
C011959	oridonin	oridonin results in decreased expression of CDH2 mRNA	30243739
C011959	oridonin	oridonin results in decreased expression of CDH2 protein	30243739
D010042	Ouabain	Ouabain results in decreased expression of CDH2 mRNA	28795476
D010042	Ouabain	Ouabain results in decreased expression of CDH2 protein	28795476
D000077150	Oxaliplatin	[Oxaliplatin co-treated with Topotecan] results in increased expression of CDH2 mRNA	25729387
D000077150	Oxaliplatin	Oxaliplatin results in increased expression of CDH2 mRNA	25729387
D010100	Oxygen	[dictamnine co-treated with Oxygen deficiency] results in decreased expression of CDH2 protein	30266538
D010100	Oxygen	Oxygen deficiency results in increased expression of CDH2 mRNA	25351418
D010100	Oxygen	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CDH2 mRNA	30529165
C500026	palbociclib	2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDH2 protein]	22869556
C500026	palbociclib	palbociclib results in increased expression of CDH2 protein	22869556
D000077767	Panobinostat	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
D000077767	Panobinostat	Panobinostat results in decreased expression of CDH2 mRNA	26272509
D052638	Particulate Matter	Particulate Matter results in increased expression of CDH2 mRNA	28846189
D052638	Particulate Matter	Particulate Matter results in increased expression of CDH2 protein	28846189
D052638	Particulate Matter	[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDH2 mRNA	30010986
D052638	Particulate Matter	Particulate Matter results in decreased expression of CDH2 protein	29673083
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of CDH2 mRNA	27294297
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of CDH2 mRNA	27181905
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of CDH2 mRNA	23892564
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CDH2 mRNA	28973641
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CDH2 protein	28973641
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CDH2 protein	25743374
D010634	Phenobarbital	Phenobarbital affects the expression of CDH2 mRNA	19482888; 23091169;
D010634	Phenobarbital	Phenobarbital results in decreased expression of CDH2 mRNA	19162173
D010656	Phenylephrine	Phenylephrine results in increased expression of CDH2 protein	17526999
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of CDH2 mRNA	26272509
D010672	Phenytoin	Phenytoin results in decreased expression of CDH2 mRNA	9118846
D010862	Pilocarpine	Pilocarpine results in increased expression of CDH2 mRNA	12125071
D010862	Pilocarpine	Pilocarpine results in increased expression of CDH2 protein	12125071; 12387456;
C006253	pirinixic acid	pirinixic acid results in decreased expression of CDH2 mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of CDH2 mRNA	19162173
D010936	Plant Extracts	HOTAIR mutant form inhibits the reaction [Plant Extracts analog results in increased expression of CDH2 protein]	25447409
D010936	Plant Extracts	Plant Extracts analog results in increased expression of CDH2 protein	25447409
D010936	Plant Extracts	Plant Extracts results in decreased expression of CDH2 protein	28371048
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 mRNA]	18572855
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Nitrogen Mustard Compounds results in decreased expression of CDH2 protein]	18572855
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of CDH2 mRNA	19162173
D011374	Progesterone	Progesterone results in decreased expression of CDH2 mRNA	17556502
D011374	Progesterone	Progesterone results in decreased expression of CDH2 mRNA	19690047
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CDH2 mRNA	24780913
D011794	Quercetin	Quercetin results in decreased expression of CDH2 mRNA	21632981
D011794	Quercetin	Quercetin results in decreased expression of CDH2 protein	22422628
D011794	Quercetin	Quercetin results in increased expression of CDH2 mRNA	15309432
D011794	Quercetin	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 mRNA]	25164625
D011794	Quercetin	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 protein]	25164625
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of CDH2 mRNA	14699072
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDH2 mRNA	19059307
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of CDH2 mRNA	16079270
D000077185	Resveratrol	Resveratrol inhibits the reaction [TGFB1 protein results in increased expression of CDH2 mRNA]	23992306
D000077185	Resveratrol	Resveratrol inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]	23992306
D000077185	Resveratrol	Resveratrol results in decreased expression of CDH2 mRNA	22692956; 23992306;
D000077185	Resveratrol	Resveratrol results in decreased expression of CDH2 protein	22692956; 23992306;
D000077185	Resveratrol	Resveratrol results in increased expression of CDH2 protein	24330398
D000077185	Resveratrol	Resveratrol inhibits the reaction [EGF protein results in increased expression of CDH2 mRNA]	21794976
C116926	rofecoxib	rofecoxib affects the expression of CDH2 mRNA	17070997
C010327	salinomycin	salinomycin inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]	30273566
C078903	seocalcitol	seocalcitol results in decreased expression of CDH2 mRNA	12040012
D018030	Silver Compounds	Silver Compounds results in increased expression of CDH2 protein	29703973
D020123	Sirolimus	Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of CDH2 mRNA]	30053495
D020123	Sirolimus	Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of CDH2 protein]	30053495
D012906	Smoke	HOTAIR mutant form inhibits the reaction [Smoke analog results in increased expression of CDH2 protein]	25447409
D012906	Smoke	Smoke analog results in increased expression of CDH2 protein	25447409
C009277	sodium arsenate	sodium arsenate results in increased expression of CDH2 mRNA	23922661
C017947	sodium arsenite	sodium arsenite affects the expression of CDH2 mRNA	19590694
C017947	sodium arsenite	HSF1 protein affects the reaction [sodium arsenite results in increased expression of CDH2 protein]	30309986
C017947	sodium arsenite	MIR191 mRNA promotes the reaction [sodium arsenite results in increased expression of CDH2 protein]	29277653
C017947	sodium arsenite	sodium arsenite deficiency inhibits the reaction [sodium arsenite results in increased expression of CDH2 protein]	28336213
C017947	sodium arsenite	sodium arsenite results in decreased expression of CDH2 mRNA	24816914
C017947	sodium arsenite	sodium arsenite results in decreased expression of CDH2 protein	24816914
C017947	sodium arsenite	sodium arsenite results in increased expression of CDH2 mRNA	27224422
C017947	sodium arsenite	sodium arsenite results in increased expression of CDH2 protein	27224422; 28336213; 29277653; 30191986; 30309986;
C016104	sodium bichromate	sodium bichromate affects the expression of CDH2 mRNA	22110744
D012969	Sodium Fluoride	[Sodium Fluoride co-treated with Sulfur Dioxide] results in decreased expression of CDH2 protein	27237588
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CDH2 mRNA	27237588
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CDH2 protein	27237588
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of CDH2 mRNA	18175754
D012999	Soman	Soman results in increased expression of CDH2 mRNA	19281266
D000077157	Sorafenib	Sorafenib promotes the reaction [destruxin B results in decreased expression of CDH2 protein]	24434019
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of CDH2 mRNA	16214533
C016766	sulforafan	sulforafan results in increased expression of CDH2 mRNA	30529165
D013458	Sulfur Dioxide	[Sodium Fluoride co-treated with Sulfur Dioxide] results in decreased expression of CDH2 protein	27237588
D013458	Sulfur Dioxide	Sulfur Dioxide results in decreased expression of CDH2 protein	27237588
D013501	Surface-Active Agents	[Surface-Active Agents co-treated with glyphosate] results in increased expression of CDH2 mRNA	22467014
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of CDH2 mRNA	31299295
D013629	Tamoxifen	Tamoxifen affects the expression of CDH2 mRNA	14699072
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in increased expression of CDH2 mRNA	19059307
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of CDH2 mRNA	15885361
D013739	Testosterone	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Testosterone results in decreased phosphorylation of CDH2 protein]	28163245
D013739	Testosterone	Testosterone results in decreased phosphorylation of CDH2 protein	28163245
D013739	Testosterone	Wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CDH2 protein]	28163245
D013739	Testosterone	[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 mRNA	25164625
D013739	Testosterone	[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 protein	25164625
D013739	Testosterone	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 mRNA]	25164625
D013739	Testosterone	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 protein]	25164625
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CDH2 mRNA	21570461; 24680724;
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CDH2 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDH2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CDH2 mRNA	27562557
D013749	Tetrachlorodibenzodioxin	[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of CDH2 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CDH2 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CDH2 mRNA	16054898; 18796159; 21215274;
D013755	Tetradecanoylphorbol Acetate	antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDH2 protein]	25656647
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of CDH2 protein	25656647
D013755	Tetradecanoylphorbol Acetate	morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDH2 protein]	28108223
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of CDH2 protein	28108223
C009438	tetrandrine	tetrandrine results in decreased expression of CDH2 protein	30549224
D014028	Tobacco Smoke Pollution	andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]	31128153
D014028	Tobacco Smoke Pollution	IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]]	31128153
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CDH2 protein	27087172; 31128153;
D014028	Tobacco Smoke Pollution	Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]	26191140
D014028	Tobacco Smoke Pollution	Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]	26191140
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CDH2 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CDH2 mRNA	26191140
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CDH2 protein	26191140; 31128153;
D019772	Topotecan	[Oxaliplatin co-treated with Topotecan] results in increased expression of CDH2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of CDH2 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of CDH2 mRNA	18230668
D014212	Tretinoin	Tretinoin results in increased expression of CDH2 protein	16149052
D014212	Tretinoin	U 0126 inhibits the reaction [Tretinoin results in increased expression of CDH2 protein]	16149052
D014212	Tretinoin	Tretinoin affects the expression of CDH2 mRNA	16211290
D014212	Tretinoin	Tretinoin results in increased expression of CDH2 mRNA	16236135
C011559	tributyltin	tributyltin results in increased expression of CDH2 mRNA	29505797
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of CDH2 mRNA	24935251; 26272509;
D014260	Triclosan	3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CDH2 protein]	28844962
D014260	Triclosan	Fulvestrant inhibits the reaction [Triclosan results in increased expression of CDH2 protein]	28844962
D014260	Triclosan	Triclosan results in decreased expression of CDH2 mRNA	30510588
D014260	Triclosan	Triclosan results in increased expression of CDH2 protein	28844962
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of CDH2 mRNA	19042947
C052920	trimethylarsine oxide	trimethylarsine oxide results in increased expression of CDH2 mRNA	17481689
C002802	tungsten carbide	[tungsten carbide binds to Cobalt] which results in increased expression of CDH2 mRNA	20105288
D014415	Tunicamycin	Tunicamycin results in increased expression of CDH2 mRNA	17127020
C113580	U 0126	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDH2 mRNA]	12710931
C113580	U 0126	U 0126 inhibits the reaction [Tretinoin results in increased expression of CDH2 protein]	16149052
C113580	U 0126	U 0126 results in decreased expression of CDH2 mRNA	30723155
C113580	U 0126	U 0126 inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]	23876460
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH2 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of CDH2 mRNA	23179753; 24383497; 26272509;
D014635	Valproic Acid	Valproic Acid results in decreased methylation of CDH2 gene	29154799
D001335	Vehicle Emissions	[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDH2 mRNA	30010986
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CDH2 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of CDH2 mRNA	19015723
D014807	Vitamin D	Vitamin D deficiency results in decreased expression of CDH2 protein	26210580
D014810	Vitamin E	[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [mono-(2-ethylhexyl)phthalate affects the localization of CDH2 protein]	29940330
D024483	Vitamin K 3	Vitamin K 3 results in decreased expression of CDH2 protein	31238027
D000077191	Wortmannin	Wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CDH2 protein]	28163245
D000077191	Wortmannin	Wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CDH2 protein]	28163245
C519885	WP1066	WP1066 inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]	28284859
C519885	WP1066	WP1066 inhibits the reaction [DDT results in increased expression of CDH2 mRNA]	24820114
C066436	zardaverine	zardaverine results in decreased localization of CDH2 protein	15082077

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-0106	Calcium
KW-0130	Cell adhesion
KW-0965	Cell junction
KW-1003	Cell membrane
KW-0165	Cleavage on pair of basic residues
KW-0325	Glycoprotein
KW-0472	Membrane
KW-0479	Metal-binding
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0677	Repeat
KW-0732	Signal
KW-0812	Transmembrane
KW-1133	Transmembrane helix

Interpro

InterPro ID	InterPro Term
IPR039808	Cadherin
IPR002126	Cadherin-like_dom
IPR015919	Cadherin-like_sf
IPR020894	Cadherin_CS
IPR000233	Cadherin_cytoplasmic-dom
IPR014868	Cadherin_pro_dom
IPR027397	Catenin_binding_dom_sf
IPR030051	CDH2

PROSITE

PROSITE ID	PROSITE Term
PS00232	CADHERIN_1
PS50268	CADHERIN_2

Pfam

Pfam ID	Pfam Term
PF00028	Cadherin
PF01049	Cadherin_C
PF08758	Cadherin_pro

Gene: CDH2

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Identified variants/mutations related to cleft phenotype

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction