| Tag | Content |
|---|---|
| Uniprot ID | P28741; Q7TSZ7; |
| Entrez ID | 16568 |
| Genbank protein ID | AAH52707.1; BAA02166.1; |
| Genbank nucleotide ID | NM_008443.4; NM_001290805.1; NM_001290806.1; |
| Ensembl protein ID | ENSMUSP00000112782 |
| Ensembl nucleotide ID | ENSMUSG00000018395 |
| Gene name | Kinesin-like protein KIF3A |
| Gene symbol | Kif3a |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO,CLP |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 20106874; 21429982; 27802276; 28346501; |
| Functional description | Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (PubMed:21670265). Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole (PubMed:23386061). |
| Sequence | MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYRQAVSVD EMRGTITVHK TDSSNEPPKT 60 FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG QTGTGKTFTM EGVRAVPGLR 120 GVIPNSFAHI FGHIAKAEGD TRFLVRVSYL EIYNEEVRDL LGKDQTQRLE VKERPDVGVY 180 IKDLSAYVVN NADDMDRIMT LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGVDGNMH 240 VRMGKLHLVD LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS 300 KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR INEDPKDALL 360 RQFQKEIEEL KKKLEEGEEV SGSDISGSEE DDEEGELGED GEKKKKRRDQ AGKKKVSPDK 420 MVEMQAKIDE ERKALETKLD MEEEERNKAR AELERREKDL LKAQQEHQSL LEKLSALEKK 480 VIVGGVDLLA KAEEQEKLLE ESNMELEERR RRAEQLRKEL EEKEQERLDI EEKYTSLQEE 540 AQGKTKKLKK VWTMLMAAKS EMADLQQEHQ REIEGLLENI RQLSRELRLQ MLIIDNFIPQ 600 DYQEMIENYV HWNEDIGEWQ LKCVAYTGNN MRKQTPVPDK KERDPFEVDL SHVYLAYTEE 660 SLRQSLMKLE RPRTSKGKAR PKMGRRKRSA KPETVIDSLL Q 701 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003777 | microtubule motor activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0008017 | microtubule binding | IDA |
| GO:0008017 | microtubule binding | IBA |
| GO:0016887 | ATPase activity | IBA |
| GO:0017137 | Rab GTPase binding | ISO |
| GO:0019894 | kinesin binding | ISO |
| GO:0019903 | protein phosphatase binding | ISO |
| GO:0030507 | spectrin binding | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0120170 | intraciliary transport particle B binding | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001701 | in utero embryonic development | IGI |
| GO:0001822 | kidney development | IMP |
| GO:0001947 | heart looping | IMP |
| GO:0007018 | microtubule-based movement | IBA |
| GO:0007224 | smoothened signaling pathway | IMP |
| GO:0007368 | determination of left/right symmetry | IMP |
| GO:0007411 | axon guidance | IBA |
| GO:0007507 | heart development | IMP |
| GO:0008089 | anterograde axonal transport | IBA |
| GO:0008544 | epidermis development | IMP |
| GO:0009952 | anterior/posterior pattern specification | IMP |
| GO:0009953 | dorsal/ventral pattern formation | IMP |
| GO:0010457 | centriole-centriole cohesion | IMP |
| GO:0015031 | protein transport | ISO |
| GO:0021542 | dentate gyrus development | IMP |
| GO:0021904 | dorsal/ventral neural tube patterning | IGI |
| GO:0021904 | dorsal/ventral neural tube patterning | IMP |
| GO:0021915 | neural tube development | IMP |
| GO:0034454 | microtubule anchoring at centrosome | IMP |
| GO:0036334 | epidermal stem cell homeostasis | IMP |
| GO:0044458 | motile cilium assembly | IMP |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | ISO |
| GO:0050679 | positive regulation of epithelial cell proliferation | IMP |
| GO:0060122 | inner ear receptor cell stereocilium organization | IMP |
| GO:0060271 | cilium assembly | IMP |
| GO:0060271 | cilium assembly | IBA |
| GO:0061351 | neural precursor cell proliferation | IMP |
| GO:0090316 | positive regulation of intracellular protein transport | ISO |
| GO:1902414 | protein localization to cell junction | ISO |
| GO:1905128 | positive regulation of axo-dendritic protein transport | ISO |
| GO:1905515 | non-motile cilium assembly | IMP |
| GO:2000771 | positive regulation of establishment or maintenance of cell polarity regulating cell shape | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005813 | centrosome | ISO |
| GO:0005814 | centriole | ISO |
| GO:0005814 | centriole | IDA |
| GO:0005829 | cytosol | TAS |
| GO:0005871 | kinesin complex | IBA |
| GO:0005874 | microtubule | IBA |
| GO:0005929 | cilium | IDA |
| GO:0005930 | axoneme | ISO |
| GO:0015630 | microtubule cytoskeleton | ISO |
| GO:0016939 | kinesin II complex | ISO |
| GO:0016939 | kinesin II complex | IDA |
| GO:0031514 | motile cilium | IDA |
| GO:0032391 | photoreceptor connecting cilium | IDA |
| GO:0043005 | neuron projection | IDA |
| GO:0043025 | neuronal cell body | ISO |
| GO:1904115 | axon cytoplasm | ISO |
| GO:0005876 | spindle microtubule | ISO |
| GO:0097470 | ribbon synapse | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-1280218 | Adaptive Immune System | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-1852241 | Organelle biogenesis and maintenance | IEA |
| R-MMU-199991 | Membrane Trafficking | IEA |
| R-MMU-2132295 | MHC class II antigen presentation | IEA |
| R-MMU-5358351 | Signaling by Hedgehog | IEA |
| R-MMU-5610787 | Hedgehog 'off' state | IEA |
| R-MMU-5617833 | Cilium Assembly | IEA |
| R-MMU-5620924 | Intraflagellar transport | IEA |
| R-MMU-5632684 | Hedgehog 'on' state | IEA |
| R-MMU-5635838 | Activation of SMO | IEA |
| R-MMU-5653656 | Vesicle-mediated transport | IEA |
| R-MMU-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | IEA |
| R-MMU-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | IEA |
| R-MMU-8856688 | Golgi-to-ER retrograde transport | IEA |
| R-MMU-983189 | Kinesins | IEA |
| R-MMU-983231 | Factors involved in megakaryocyte development and platelet production | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0067 | ATP-binding |
| KW-0966 | Cell projection |
| KW-0969 | Cilium |
| KW-0970 | Cilium biogenesis/degradation |
| KW-0175 | Coiled coil |
| KW-0963 | Cytoplasm |
| KW-0206 | Cytoskeleton |
| KW-0493 | Microtubule |
| KW-0505 | Motor protein |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| Pfam ID | Pfam Term |
|---|---|
| PF00225 | Kinesin |