CleftGeneDB-Search

Gene: GSTT1

Basic information

Tag	Content
Uniprot ID	P30711; O00226; Q5TZY2; Q6IC69; Q969K8; Q96IY3;
Entrez ID	2952
Genbank protein ID	AAG02374.1; BAB39498.1; AAL31549.1; CAG30385.1; AAV38754.1; AAH07065.1; CAA55935.1;
Genbank nucleotide ID	NM_001293810.1; NM_001293811.1; NM_000853.3; NM_001293808.1; NM_001293807.1; NM_001293812.1; NM_001293809.1;
Ensembl protein ID	ENSP00000481741
Ensembl nucleotide ID	ENSG00000277656
Gene name	Glutathione S-transferase theta-1
Gene symbol	GSTT1
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type	CL/P
Developmental stage
Data sources	Manually collected
Reference	17160896; 16135950;
Functional description	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
Sequence	MGLELYLDLL SQPCRAVYIF AKKNDIPFEL RIVDLIKGQH LSDAFAQVNP LKKVPALKDG 60 DFTLTESVAI LLYLTRKYKV PDYWYPQDLQ ARARVDEYLA WQHTTLRRSC LRALWHKVMF 120 PVFLGEPVSP QTLAATLAEL DVTLQLLEDK FLQNKAFLTG PHISLADLVA ITELMHPVGA 180 GCQVFEGRPK LATWRQRVEA AVGEDLFQEA HEVILKAKDF PPADPTIKQK LMPWVLAMIR 240

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

PDB ID
2C3N
2C3Q
2C3T

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs1216627902	p.Gly2Cys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24042041C>A	gnomAD
rs777890225	p.Leu3Val	missense variant	-	CHR_HSCHR22_1_CTG7:g.24042038G>C	ExAC,gnomAD
rs1439706306	p.Glu4Lys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24042035C>T	gnomAD
rs748255226	p.Leu10Pro	missense variant	-	CHR_HSCHR22_1_CTG7:g.24042016A>G	ExAC,gnomAD
rs1460430655	p.Gln12Ter	stop gained	-	CHR_HSCHR22_1_CTG7:g.24042011G>A	gnomAD
rs780072339	p.Cys14Gly	missense variant	-	CHR_HSCHR22_1_CTG7:g.24042005A>C	ExAC,gnomAD
rs750233797	p.Ile19Val	missense variant	-	CHR_HSCHR22_1_CTG7:g.24041990T>C	ExAC,gnomAD
rs1161555784	p.Ile19Ser	missense variant	-	CHR_HSCHR22_1_CTG7:g.24041989A>C	gnomAD
rs2266635	p.Ala21Thr	missense variant	-	CHR_HSCHR22_1_CTG7:g.24041984C>T	1000Genomes,ExAC,gnomAD
rs1173289463	p.Asn24Ser	missense variant	-	CHR_HSCHR22_1_CTG7:g.24041974T>C	gnomAD
rs1175516156	p.Arg31His	missense variant	-	CHR_HSCHR22_1_CTG7:g.24041953C>T	gnomAD
rs1480595059	p.Ile32Val	missense variant	-	CHR_HSCHR22_1_CTG7:g.24041951T>C	gnomAD
rs1207230959	p.Leu35Met	missense variant	-	CHR_HSCHR22_1_CTG7:g.24041942G>T	gnomAD
rs763673553	p.Ile36Leu	missense variant	-	CHR_HSCHR22_1_CTG7:g.24041939T>G	ExAC,gnomAD
rs1233179552	p.Ile36Met	missense variant	-	CHR_HSCHR22_1_CTG7:g.24041937A>C	gnomAD
rs762389722	p.Gly38Arg	missense variant	-	CHR_HSCHR22_1_CTG7:g.24041933C>G	ExAC,gnomAD
rs1195148457	p.His40Tyr	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039595G>A	gnomAD
rs199521920	p.Asp43Asn	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039586C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs199521920	p.Asp43Tyr	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039586C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs758023485	p.Ala46Gly	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039576G>C	ExAC,gnomAD
rs747759286	p.Pro50Thr	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039565G>T	ExAC
rs778558825	p.Leu51Ile	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039562G>T	ExAC
rs1347375526	p.Lys52Asn	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039557C>G	gnomAD
rs1304259047	p.Val54Met	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039553C>T	gnomAD
rs1334043459	p.Pro55Thr	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039550G>T	gnomAD
rs1328859571	p.Pro55Leu	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039549G>A	gnomAD
rs754429237	p.Leu57Phe	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039542C>G	ExAC,gnomAD
rs754429237	p.Leu57Phe	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039542C>A	ExAC,gnomAD
rs370330123	p.Gly60Glu	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039534C>T	ExAC,gnomAD
rs766908708	p.Gly60Arg	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039535C>T	ExAC,gnomAD
rs1394034450	p.Asp61Asn	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039532C>T	gnomAD
rs587740336	p.Thr65Met	missense variant	-	CHR_HSCHR22_1_CTG7:g.24039519G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs371582086	p.Val68Ala	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037322A>G	ExAC,gnomAD
rs1233172648	p.Leu74Met	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037305G>T	gnomAD
rs756616838	p.Thr75Met	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037301G>A	ExAC,gnomAD
rs56023617	p.Arg76Cys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037299G>A	ExAC,gnomAD
rs56023617	p.Arg76Ser	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037299G>T	ExAC,gnomAD
rs1317034472	p.Arg76His	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037298C>T	gnomAD
rs1312329976	p.Tyr78Cys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037292T>C	gnomAD
rs1457363932	p.Lys79Arg	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037289T>C	gnomAD
rs751974027	p.Val80Phe	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037287C>A	ExAC,gnomAD
rs751974027	p.Val80Ile	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037287C>T	ExAC,gnomAD
rs1162755869	p.Trp84Ter	stop gained	-	CHR_HSCHR22_1_CTG7:g.24037273C>T	gnomAD
rs1183341374	p.Leu89Val	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037260G>C	gnomAD
rs765273007	p.Arg92Cys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037251G>A	ExAC,gnomAD
rs759683869	p.Arg92His	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037250C>T	ExAC
rs1194157389	p.Ala93Thr	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037248C>T	gnomAD
rs367612218	p.Arg94His	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037244C>T	ExAC,gnomAD
rs376939579	p.Arg94Cys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037245G>A	ExAC,TOPMed,gnomAD
rs141759372	p.Trp101Arg	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037224A>G	1000Genomes,ExAC,gnomAD
rs774192152	p.His103Asn	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037218G>T	ExAC
rs768335896	p.His103Arg	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037217T>C	ExAC
rs745381166	p.Thr104Lys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037214G>T	ExAC,gnomAD
rs11550605	p.Thr104Pro	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037215T>G	1000Genomes,ExAC,gnomAD
rs11550605	p.Thr104Ala	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037215T>C	1000Genomes,ExAC,gnomAD
rs745381166	p.Thr104Met	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037214G>A	ExAC,gnomAD
rs1269298778	p.Leu106Pro	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037208A>G	gnomAD
rs373763515	p.Arg107Trp	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037206G>A	ExAC,gnomAD
rs201658659	p.Arg107Gln	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037205C>T	1000Genomes,ExAC,gnomAD
rs1350334124	p.Arg112Gln	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037190C>T	gnomAD
rs150601402	p.Arg112Trp	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037191G>A	ExAC,gnomAD
rs1256424411	p.Lys117Asn	missense variant	-	CHR_HSCHR22_1_CTG7:g.24037174C>G	gnomAD
rs1433883691	p.Met119Thr	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034807A>G	gnomAD
rs780904841	p.Val122Leu	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034799C>G	ExAC
rs771540638	p.Phe123Ser	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034795A>G	ExAC,gnomAD
rs1353763345	p.Leu124Val	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034793G>C	gnomAD
rs1176044350	p.Gly125Ser	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034790C>T	gnomAD
rs747558254	p.Glu126Lys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034787C>T	ExAC,gnomAD
rs1233821564	p.Pro127Arg	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034783G>C	gnomAD
rs1207690468	p.Ser129Phe	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034777G>A	gnomAD
rs1483843490	p.Gln131His	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034770C>G	gnomAD
rs1277804957	p.Ala134Thr	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034763C>T	gnomAD
rs1209663237	p.Ala135Thr	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034760C>T	gnomAD
rs587657751	p.Asp141Gly	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034741T>C	1000Genomes,ExAC,gnomAD
rs1411486207	p.Val142Met	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034739C>T	gnomAD
rs1312573641	p.Gln145Ter	stop gained	-	CHR_HSCHR22_1_CTG7:g.24034730G>A	gnomAD
rs1466733729	p.Leu147Arg	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034723A>C	gnomAD
rs1156927929	p.Glu148Lys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034721C>T	gnomAD
rs755288472	p.Ala156Thr	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034697C>T	ExAC,gnomAD
rs369014577	p.Leu158Phe	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034691G>A	ExAC,gnomAD
rs139881998	p.His162Leu	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034678T>A	1000Genomes,ExAC,gnomAD
rs756221246	p.Ile163Val	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034676T>C	ExAC,TOPMed,gnomAD
rs587699030	p.Leu165Ser	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034669A>G	1000Genomes,ExAC,gnomAD
rs2266637	p.Val169Ile	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034658C>T	1000Genomes,ExAC,gnomAD
rs2234953	p.Glu173Lys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034646C>T	-
rs2234953	p.Glu173Lys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034646C>T	UniProt,dbSNP
VAR_014504	p.Glu173Lys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034646C>T	UniProt
rs1166619589	p.Gly181Ala	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034417C>G	gnomAD
rs201764803	p.Glu186Lys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034403C>T	ExAC,gnomAD
rs1293750813	p.Arg188Gln	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034396C>T	gnomAD
rs144686326	p.Arg188Ter	stop gained	-	CHR_HSCHR22_1_CTG7:g.24034397G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs758416213	p.Trp194Ter	stop gained	-	CHR_HSCHR22_1_CTG7:g.24034378C>T	ExAC,gnomAD
rs752856562	p.Arg195Trp	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034376G>A	ExAC,gnomAD
rs765120099	p.Arg195Gln	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034375C>T	ExAC,gnomAD
rs955662177	p.Arg197Cys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034370G>A	TOPMed
rs112867476	p.Arg197His	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034369C>T	ExAC,gnomAD
rs766134636	p.Val198Met	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034367C>T	ExAC,gnomAD
rs760258346	p.Val202Met	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034355C>T	ExAC,gnomAD
rs772837721	p.Phe207Ser	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034339A>G	ExAC,gnomAD
rs772438354	p.Glu212Lys	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034325C>T	ExAC,gnomAD
rs1467099794	p.Val213Ile	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034322C>T	gnomAD
rs748732133	p.Lys216Asn	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034311C>A	ExAC,gnomAD
rs774754785	p.Pro222Ala	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034295G>C	ExAC,gnomAD
rs768963258	p.Pro222Leu	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034294G>A	ExAC,gnomAD
rs749671214	p.Asp224Val	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034288T>A	ExAC,gnomAD
rs370201073	p.Pro225Ser	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034286G>A	ExAC,TOPMed,gnomAD
rs370201073	p.Pro225Thr	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034286G>T	ExAC,TOPMed,gnomAD
rs765356551	p.Ile227Val	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034280T>C	ExAC,gnomAD
rs185499198	p.Arg240Trp	missense variant	-	CHR_HSCHR22_1_CTG7:g.24034241G>A	1000Genomes,ExAC,gnomAD
rs143079560	p.Ter241Trp	stop lost	-	CHR_HSCHR22_1_CTG7:g.24034236T>C	ExAC,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0000768	Congenital Abnormality	group	BEFREE
C0001339	Acute pancreatitis	disease	BEFREE
C0001403	Addison Disease	disease	BEFREE
C0001418	Adenocarcinoma	group	BEFREE;LHGDN
C0001430	Adenoma	group	LHGDN
C0001857	AIDS related complex	disease	BEFREE
C0001973	Alcoholic Intoxication, Chronic	disease	BEFREE
C0002395	Alzheimer's Disease	disease	BEFREE;LHGDN
C0002871	Anemia	disease	BEFREE
C0002874	Aplastic Anemia	disease	BEFREE;LHGDN
C0002875	Cooley's anemia	disease	BEFREE
C0002895	Anemia, Sickle Cell	disease	BEFREE
C0003850	Arteriosclerosis	disease	BEFREE
C0003873	Rheumatoid Arthritis	disease	BEFREE;LHGDN
C0003949	Asbestosis	disease	BEFREE;CTD_human
C0004093	Asthenia	phenotype	BEFREE
C0004096	Asthma	disease	BEFREE;LHGDN
C0004114	Astrocytoma	disease	BEFREE
C0004153	Atherosclerosis	disease	BEFREE
C0004364	Autoimmune Diseases	group	BEFREE;LHGDN
C0004403	Autosome Abnormalities	group	CTD_human
C0004509	Azoospermia	disease	BEFREE
C0004779	Basal Cell Nevus Syndrome	disease	BEFREE
C0004943	Behcet Syndrome	disease	LHGDN
C0005586	Bipolar Disorder	disease	BEFREE;PSYGENET
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE;LHGDN
C0006111	Brain Diseases	group	BEFREE
C0006118	Brain Neoplasms	group	BEFREE;LHGDN
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0006826	Malignant Neoplasms	group	CTD_human
C0007097	Carcinoma	group	CTD_human
C0007102	Malignant tumor of colon	disease	BEFREE
C0007103	Malignant neoplasm of endometrium	disease	BEFREE
C0007107	Malignant neoplasm of larynx	disease	BEFREE
C0007114	Malignant neoplasm of skin	disease	BEFREE;CTD_human
C0007115	Malignant neoplasm of thyroid	disease	BEFREE
C0007121	Bronchogenic Carcinoma	disease	BEFREE
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE
C0007134	Renal Cell Carcinoma	disease	BEFREE;CTD_human
C0007137	Squamous cell carcinoma	disease	BEFREE;LHGDN
C0007138	Carcinoma, Transitional Cell	disease	BEFREE
C0007222	Cardiovascular Diseases	group	BEFREE;LHGDN
C0007273	Carotid Artery Diseases	group	LHGDN
C0007286	Carpal Tunnel Syndrome	disease	BEFREE
C0007847	Malignant tumor of cervix	disease	BEFREE
C0007867	Cervix Diseases	group	BEFREE
C0007868	Cervical dysplasia	disease	BEFREE
C0007873	Uterine Cervical Neoplasm	disease	BEFREE
C0008495	Chorioamnionitis	phenotype	LHGDN
C0008625	Chromosome Aberrations	group	CTD_human
C0008626	Congenital chromosomal disease	group	BEFREE
C0008677	Bronchitis, Chronic	disease	BEFREE
C0008924	Cleft upper lip	disease	BEFREE
C0008925	Cleft Palate	disease	BEFREE
C0009324	Ulcerative Colitis	disease	BEFREE
C0009373	Colonic Diseases	group	BEFREE
C0009375	Colonic Neoplasms	group	BEFREE;LHGDN
C0009402	Colorectal Carcinoma	disease	BEFREE
C0009404	Colorectal Neoplasms	group	LHGDN
C0010054	Coronary Arteriosclerosis	disease	BEFREE
C0010068	Coronary heart disease	disease	BEFREE
C0010346	Crohn Disease	disease	BEFREE
C0010674	Cystic Fibrosis	disease	BEFREE
C0011570	Mental Depression	disease	PSYGENET
C0011581	Depressive disorder	disease	PSYGENET
C0011609	Drug Eruptions	group	LHGDN
C0011615	Dermatitis, Atopic	disease	BEFREE;LHGDN
C0011847	Diabetes	disease	BEFREE
C0011849	Diabetes Mellitus	group	BEFREE;LHGDN
C0011854	Diabetes Mellitus, Insulin-Dependent	disease	BEFREE;RGD
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	disease	BEFREE
C0011882	Diabetic Neuropathies	group	BEFREE
C0011884	Diabetic Retinopathy	disease	BEFREE
C0011991	Diarrhea	phenotype	BEFREE
C0013595	Eczema	disease	BEFREE
C0014175	Endometriosis	disease	BEFREE;LHGDN
C0014859	Esophageal Neoplasms	group	BEFREE
C0015230	Exanthema	phenotype	BEFREE
C0015397	Disorder of eye	group	BEFREE
C0015625	Fanconi Anemia	disease	BEFREE
C0016059	Fibrosis	phenotype	LHGDN
C0016978	gallbladder neoplasm	disease	LHGDN
C0017154	Gastritis, Atrophic	disease	BEFREE
C0017601	Glaucoma	disease	BEFREE
C0017612	Glaucoma, Open-Angle	disease	LHGDN
C0017636	Glioblastoma	disease	BEFREE;CTD_human;LHGDN
C0017638	Glioma	disease	BEFREE
C0018790	Cardiac Arrest	disease	BEFREE
C0019156	Hepatic Veno-Occlusive Disease	disease	BEFREE
C0019158	Hepatitis	disease	BEFREE;LHGDN
C0019159	Hepatitis A	disease	BEFREE
C0019163	Hepatitis B	disease	BEFREE
C0019193	Hepatitis, Toxic	disease	CTD_human
C0019196	Hepatitis C	disease	BEFREE
C0019829	Hodgkin Disease	disease	BEFREE
C0020538	Hypertensive disease	group	BEFREE;CTD_human;LHGDN
C0020557	Hypertriglyceridemia	phenotype	BEFREE
C0021364	Male infertility	disease	BEFREE
C0021390	Inflammatory Bowel Diseases	group	BEFREE;LHGDN
C0022658	Kidney Diseases	group	BEFREE
C0022661	Kidney Failure, Chronic	disease	BEFREE;LHGDN
C0022665	Kidney Neoplasm	disease	CTD_human
C0023051	Laryngeal Diseases	group	BEFREE
C0023418	leukemia	disease	BEFREE;LHGDN
C0023434	Chronic Lymphocytic Leukemia	disease	LHGDN
C0023449	Acute lymphocytic leukemia	disease	BEFREE
C0023452	Childhood Acute Lymphoblastic Leukemia	disease	BEFREE
C0023467	Leukemia, Myelocytic, Acute	disease	BEFREE;LHGDN
C0023473	Myeloid Leukemia, Chronic	disease	BEFREE
C0023487	Acute Promyelocytic Leukemia	disease	BEFREE
C0023530	Leukopenia	disease	BEFREE
C0023531	Leukoplakia	disease	BEFREE
C0023532	Leukoplakia, Oral	disease	BEFREE
C0023890	Liver Cirrhosis	disease	BEFREE
C0023891	Liver Cirrhosis, Alcoholic	disease	BEFREE
C0023896	Alcoholic Liver Diseases	group	BEFREE
C0023903	Liver neoplasms	group	BEFREE
C0024115	Lung diseases	group	BEFREE
C0024121	Lung Neoplasms	group	CTD_human;LHGDN
C0024141	Lupus Erythematosus, Systemic	disease	BEFREE
C0024299	Lymphoma	group	BEFREE;LHGDN
C0024301	Lymphoma, Follicular	disease	BEFREE
C0024305	Lymphoma, Non-Hodgkin	disease	BEFREE;LHGDN
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0025149	Medulloblastoma	disease	BEFREE
C0025202	melanoma	disease	BEFREE
C0025286	Meningioma	disease	BEFREE
C0025568	Metaplasia	phenotype	LHGDN
C0026640	Mouth Neoplasms	group	LHGDN
C0026764	Multiple Myeloma	disease	BEFREE;CTD_human
C0026769	Multiple Sclerosis	disease	BEFREE
C0026985	Myelodysplasia	disease	BEFREE
C0027051	Myocardial Infarction	disease	BEFREE;LHGDN
C0027627	Neoplasm Metastasis	phenotype	BEFREE;LHGDN
C0027651	Neoplasms	group	CTD_human
C0027663	Neoplasms, Multiple Primary	group	BEFREE
C0027726	Nephrotic Syndrome	group	LHGDN
C0027947	Neutropenia	disease	BEFREE
C0028754	Obesity	disease	BEFREE
C0028960	Oligospermia	disease	BEFREE
C0029132	Disorder of the optic nerve	group	BEFREE
C0029134	Optic Neuritis	disease	BEFREE
C0029463	Osteosarcoma	disease	BEFREE
C0029925	Ovarian Carcinoma	disease	BEFREE
C0030305	Pancreatitis	disease	BEFREE;LHGDN
C0030567	Parkinson Disease	disease	BEFREE
C0031106	Periodontitis, Juvenile	disease	LHGDN
C0031117	Peripheral Neuropathy	group	BEFREE
C0031736	Polymorphous light eruption	disease	BEFREE
C0032285	Pneumonia	disease	BEFREE
C0032460	Polycystic Ovary Syndrome	disease	BEFREE
C0032463	Polycythemia Vera	disease	BEFREE
C0032927	Precancerous Conditions	group	BEFREE
C0033578	Prostatic Neoplasms	group	CTD_human;LHGDN
C0033860	Psoriasis	disease	BEFREE
C0033975	Psychotic Disorders	group	BEFREE
C0034734	Raynaud Disease	disease	CTD_human
C0034735	Raynaud Phenomenon	disease	CTD_human
C0034885	Rectal Neoplasms	group	BEFREE
C0036341	Schizophrenia	disease	BEFREE;PSYGENET
C0036646	Age-related cataract	disease	BEFREE
C0037285	Skin Manifestations	group	BEFREE
C0037286	Skin Neoplasms	group	CTD_human
C0038356	Stomach Neoplasms	group	LHGDN
C0040136	Thyroid Neoplasm	disease	LHGDN
C0041296	Tuberculosis	disease	BEFREE
C0041582	Ulcer	disease	BEFREE
C0042341	Varicocele	disease	BEFREE
C0042769	Virus Diseases	group	BEFREE
C0042900	Vitiligo	disease	BEFREE
C0042963	Vomiting	phenotype	BEFREE
C0043144	Wheezing	phenotype	BEFREE
C0079731	B-Cell Lymphomas	group	BEFREE
C0079744	Diffuse Large B-Cell Lymphoma	disease	BEFREE
C0079745	Lymphoma, Large-Cell, Follicular	disease	BEFREE
C0085580	Essential Hypertension	disease	BEFREE
C0085605	Liver Failure	disease	BEFREE
C0085669	Acute leukemia	disease	BEFREE
C0085695	Chronic gastritis	disease	BEFREE
C0086543	Cataract	disease	BEFREE;LHGDN
C0086692	Benign Neoplasm	group	CTD_human
C0149521	Pancreatitis, Chronic	disease	BEFREE
C0149925	Small cell carcinoma of lung	disease	BEFREE;LHGDN
C0151546	Oral Cavity Carcinoma	disease	BEFREE
C0151744	Myocardial Ischemia	disease	BEFREE
C0151779	Cutaneous Melanoma	disease	BEFREE
C0152013	Adenocarcinoma of lung (disorder)	disease	BEFREE
C0152018	Esophageal carcinoma	disease	BEFREE
C0152021	Congenital heart disease	group	BEFREE
C0153381	Malignant neoplasm of mouth	disease	BEFREE
C0153392	Malignant neoplasm of nasopharynx	disease	BEFREE
C0153405	Malignant neoplasm of pharynx	disease	BEFREE
C0155017	Color Blindness, Blue	disease	BEFREE
C0155626	Acute myocardial infarction	disease	BEFREE
C0155877	Allergic asthma	disease	BEFREE
C0162309	Adrenoleukodystrophy	disease	BEFREE
C0162566	Porphyria Cutanea Tarda	disease	BEFREE
C0178874	Tumor Progression	phenotype	BEFREE
C0205696	Anaplastic carcinoma	disease	CTD_human
C0205697	Carcinoma, Spindle-Cell	disease	CTD_human
C0205698	Undifferentiated carcinoma	phenotype	CTD_human
C0205699	Carcinomatosis	phenotype	CTD_human
C0205748	Dysplastic Nevus	disease	BEFREE
C0206708	Cervical Intraepithelial Neoplasia	disease	BEFREE
C0220603	Childhood Brain Neoplasm	disease	BEFREE
C0220612	Childhood Non-Hodgkin Lymphoma	disease	BEFREE
C0220615	Adult Acute Myeloblastic Leukemia	disease	BEFREE
C0220624	Adult Brain Neoplasm	disease	BEFREE
C0220641	Lip and Oral Cavity Carcinoma	disease	BEFREE
C0220810	Congenital defects	group	BEFREE
C0221052	Chronic berylliosis	disease	BEFREE
C0233794	Memory impairment	phenotype	BEFREE
C0235974	Pancreatic carcinoma	disease	BEFREE
C0236733	Amphetamine-Related Disorders	group	CTD_human
C0236804	Amphetamine Addiction	disease	CTD_human
C0236807	Amphetamine Abuse	disease	CTD_human
C0238301	Cancer of Nasopharynx	disease	BEFREE
C0239946	Fibrosis, Liver	disease	BEFREE
C0241910	Hepatitis, Autoimmune	disease	LHGDN
C0241982	Bulla of lung	disease	BEFREE
C0242379	Malignant neoplasm of lung	disease	BEFREE;CTD_human
C0242383	Age related macular degeneration	disease	BEFREE;LHGDN
C0242647	Mucosa-Associated Lymphoid Tissue Lymphoma	disease	BEFREE;LHGDN
C0260037	Multiple tumors	phenotype	BEFREE
C0264408	Childhood asthma	disease	BEFREE
C0268138	Xeroderma Pigmentosum, Complementation Group D	disease	BEFREE
C0268398	Familial lichen amyloidosis	disease	BEFREE
C0268615	5,10-Methylenetetrahydrofolate reductase deficiency	disease	BEFREE
C0271160	Cortical cataract	phenotype	BEFREE
C0271907	Acquired aplastic anemia	disease	BEFREE
C0278701	Gastric Adenocarcinoma	disease	BEFREE
C0278704	Malignant Childhood Neoplasm	group	BEFREE
C0278996	Malignant Head and Neck Neoplasm	disease	BEFREE
C0279626	Squamous cell carcinoma of esophagus	disease	BEFREE;CTD_human
C0279671	Cervical Squamous Cell Carcinoma	disease	BEFREE
C0279680	Transitional cell carcinoma of bladder	disease	BEFREE
C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	disease	CTD_human
C0280324	Laryngeal Squamous Cell Carcinoma	disease	BEFREE
C0280449	secondary acute myeloid leukemia	disease	BEFREE
C0281361	Adenocarcinoma of pancreas	disease	BEFREE
C0302592	Cervix carcinoma	disease	BEFREE
C0333873	Squamous intraepithelial lesion	phenotype	BEFREE
C0333875	High-Grade Squamous Intraepithelial Lesions	phenotype	BEFREE
C0334579	Anaplastic astrocytoma	disease	BEFREE
C0334588	Giant Cell Glioblastoma	disease	CTD_human
C0334619	HODGKIN'S AND NON-HODGKIN'S LYMPHOMA	disease	BEFREE
C0338507	Non-arteritic ischemic optic neuropathy	disease	BEFREE
C0338508	Optic Atrophy, Autosomal Dominant	disease	BEFREE
C0338656	Impaired cognition	disease	BEFREE
C0339573	Glaucoma, Primary Open Angle	disease	BEFREE
C0340170	Complicated pneumoconiosis	disease	BEFREE
C0343641	Human papilloma virus infection	disease	BEFREE
C0345967	Malignant mesothelioma	disease	BEFREE
C0346647	Malignant neoplasm of pancreas	disease	BEFREE
C0349204	Nonorganic psychosis	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE;CTD_human
C0376544	Hematopoietic Neoplasms	group	BEFREE
C0376670	Pancreatitis, Alcoholic	disease	BEFREE
C0400966	Non-alcoholic Fatty Liver Disease	disease	BEFREE;CTD_human
C0403823	Asthenozoospermia	disease	BEFREE;CTD_human
C0432412	Chromosome 8, trisomy	disease	BEFREE
C0476089	Endometrial Carcinoma	disease	BEFREE
C0542271	Environmental Carcinogenesis	phenotype	BEFREE
C0546837	Malignant neoplasm of esophagus	disease	BEFREE
C0549473	Thyroid carcinoma	disease	BEFREE
C0566602	Primary sclerosing cholangitis	disease	BEFREE
C0585442	Osteosarcoma of bone	disease	BEFREE
C0595989	Carcinoma of larynx	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0598766	Leukemogenesis	disease	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0677886	Epithelial ovarian cancer	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0684249	Carcinoma of lung	disease	BEFREE
C0685938	Malignant neoplasm of gastrointestinal tract	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0699893	Skin carcinoma	disease	BEFREE
C0740457	Malignant neoplasm of kidney	disease	BEFREE;CTD_human
C0741682	Premenopausal breast cancer	disease	BEFREE
C0742343	Acute Chest Syndrome	disease	BEFREE
C0744855	hepatitis immune	disease	BEFREE
C0747845	early pregnancy	phenotype	BEFREE
C0810364	Cleft Lip with or without Cleft Palate	disease	BEFREE
C0848558	Hypospadias	group	BEFREE
C0850666	Infection caused by Helicobacter pylori	disease	BEFREE
C0850741	Smoker's lung	disease	BEFREE
C0852949	Arteriopathic disease	group	BEFREE
C0853879	Invasive carcinoma of breast	disease	BEFREE
C0860207	Drug-Induced Liver Disease	disease	BEFREE;CTD_human
C0919267	ovarian neoplasm	disease	BEFREE;LHGDN
C0940937	precancerous lesions	phenotype	BEFREE
C0948380	Colorectal cancer metastatic	disease	BEFREE
C0949059	Polyp of large intestine	disease	BEFREE
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1168401	Squamous cell carcinoma of the head and neck	disease	BEFREE
C1262760	Hepatitis, Drug-Induced	disease	CTD_human
C1266042	Chromophobe Renal Cell Carcinoma	disease	CTD_human
C1266043	Sarcomatoid Renal Cell Carcinoma	disease	CTD_human
C1266044	Collecting Duct Carcinoma of the Kidney	disease	CTD_human
C1292769	Precursor B-cell lymphoblastic leukemia	disease	BEFREE
C1292778	Chronic myeloproliferative disorder	disease	BEFREE
C1302401	Adenoma of large intestine	disease	BEFREE
C1302547	Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma	disease	BEFREE
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1306837	Papillary Renal Cell Carcinoma	disease	CTD_human
C1319315	Adenocarcinoma of large intestine	disease	BEFREE
C1332153	Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome	disease	BEFREE
C1332977	Childhood Leukemia	disease	BEFREE
C1333763	Gastric Cardia Carcinoma	disease	BEFREE
C1333990	Hereditary Nonpolyposis Colorectal Cancer	disease	BEFREE
C1336076	Sporadic Breast Carcinoma	disease	BEFREE
C1336708	Testicular Germ Cell Tumor	disease	BEFREE
C1336735	Treatment related acute myeloid leukaemia	disease	BEFREE
C1337013	Differentiated Thyroid Gland Carcinoma	disease	BEFREE
C1378703	Renal carcinoma	disease	BEFREE
C1402315	Vascular lesions	disease	BEFREE
C1458155	Mammary Neoplasms	group	LHGDN
C1512433	Cervical high grade squamous intraepithelial lesion	disease	BEFREE
C1518005	Low Grade Cervical Squamous Intraepithelial Neoplasia	disease	BEFREE
C1527249	Colorectal Cancer	disease	BEFREE
C1527336	Sjogren's Syndrome	disease	BEFREE
C1561643	Chronic Kidney Diseases	group	BEFREE
C1621958	Glioblastoma Multiforme	disease	CTD_human
C1691215	Penile hypospadias	disease	BEFREE
C1704272	Benign Prostatic Hyperplasia	disease	BEFREE
C1762616	Meningioma, benign, no ICD-O subtype	disease	BEFREE
C1827377	Slow acetylator due to N-acetyltransferase enzyme variant	disease	BEFREE
C1837217	Cleft lip, isolated	disease	BEFREE
C1837218	Cleft palate, isolated	disease	BEFREE
C1847835	VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	disease	BEFREE
C1861305	TARSAL-CARPAL COALITION SYNDROME	disease	BEFREE
C1883486	Uterine Corpus Cancer	disease	BEFREE
C1956346	Coronary Artery Disease	disease	BEFREE;LHGDN
C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	disease	BEFREE
C2103602	Autoimmune Primary Adrenal Insufficiency	disease	BEFREE
C2145472	Urothelial Carcinoma	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE;LHGDN
C2316810	Chronic kidney disease stage 5	disease	BEFREE
C2609129	Autoimmune pancreatitis	disease	BEFREE
C2930617	Pulmonary Fibrosis - from Asbestos Exposure	disease	CTD_human
C2931822	Nasopharyngeal carcinoma	disease	BEFREE
C2981150	Uranostaphyloschisis	disease	BEFREE
C3241937	Nonalcoholic Steatohepatitis	disease	CTD_human
C3463824	MYELODYSPLASTIC SYNDROME	group	BEFREE;LHGDN
C3495559	Juvenile arthritis	disease	LHGDN
C3544321	Treatment-resistant schizophrenia	disease	BEFREE
C3658290	Drug-Induced Acute Liver Injury	disease	CTD_human
C3811653	Experimental Organism Basal Cell Carcinoma	phenotype	BEFREE
C3826743	Anemia in children	disease	BEFREE
C4021813	Oral cleft	disease	BEFREE
C4048328	cervical cancer	disease	BEFREE
C4277682	Chemical and Drug Induced Liver Injury	disease	CTD_human
C4279912	Chemically-Induced Liver Toxicity	disease	CTD_human

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0004364	glutathione transferase activity	IDA
GO:0004364	glutathione transferase activity	IBA
GO:0004602	glutathione peroxidase activity	IDA
GO:0005515	protein binding	IPI

GO:Biological Process

GO ID	GO Term	Evidence
GO:0006749	glutathione metabolic process	IDA
GO:0006749	glutathione metabolic process	IBA
GO:0098869	cellular oxidant detoxification	IEA
GO:1901687	glutathione derivative biosynthetic process	TAS

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005737	cytoplasm	IBA
GO:0005829	cytosol	IDA
GO:0005829	cytosol	TAS
GO:0070062	extracellular exosome	HDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-156580	Phase II - Conjugation of compounds	TAS
R-HSA-156590	Glutathione conjugation	TAS
R-HSA-211859	Biological oxidations	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	1,2-dithiol-3-thione results in increased expression of GSTT1 mRNA	19162173; 19695238;
C007606	1,2-epoxy-3-(p-nitrophenoxy)propane	GSTT1 protein affects the metabolism of 1,2-epoxy-3-(p-nitrophenoxy)propane	14508638
C007606	1,2-epoxy-3-(p-nitrophenoxy)propane	GSTT1 gene SNP inhibits the reaction [GSTT1 protein results in increased glutathionylation of 1,2-epoxy-3-(p-nitrophenoxy)propane]	21781954; 21781954;
C007606	1,2-epoxy-3-(p-nitrophenoxy)propane	GSTT1 protein affects the metabolism of 1,2-epoxy-3-(p-nitrophenoxy)propane	15683365; 15882759;
C007606	1,2-epoxy-3-(p-nitrophenoxy)propane	GSTT1 protein results in increased glutathionylation of 1,2-epoxy-3-(p-nitrophenoxy)propane	19664997; 21781954;
C007606	1,2-epoxy-3-(p-nitrophenoxy)propane	GSTT1 protein affects the metabolism of 1,2-epoxy-3-(p-nitrophenoxy)propane	17827337; 9854036;
C007606	1,2-epoxy-3-(p-nitrophenoxy)propane	GSTT1 protein affects the metabolism of 1,2-epoxy-3-(p-nitrophenoxy)propane	1848757
C007606	1,2-epoxy-3-(p-nitrophenoxy)propane	GSTT1 protein affects the metabolism of and results in decreased activity of 1,2-epoxy-3-(p-nitrophenoxy)propane	8951341
C007606	1,2-epoxy-3-(p-nitrophenoxy)propane	GSTT1 protein affects the metabolism of and results in decreased susceptibility to 1,2-epoxy-3-(p-nitrophenoxy)propane	7578934
C031763	1,3-butadiene	GSTT1 affects the abundance of 1,3-butadiene metabolite	16949064
C031763	1,3-butadiene	GSTT1 gene polymorphism promotes the reaction [EPHX1 gene polymorphism results in increased susceptibility to 1,3-butadiene]	11238181
C023891	1,3-dichloro-1-propene	GSTT1 protein affects the metabolism of and results in increased activity of 1,3-dichloro-1-propene	15790493
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of GSTT1 mRNA	22496397
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTT1 mRNA	18723825; 22496397; 22698814; 27413110; 28903501;
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTT1 mRNA]	22496397
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GSTT1 mRNA	16054899
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of GSTT1 mRNA	12883083
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of GSTT1 mRNA	21920950
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	GSTT1 gene polymorphism affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	22564066
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	GSTT1 gene polymorphism affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	22564066
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of GSTT1 mRNA]	28655636
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of GSTT1 mRNA]	28655636
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in decreased expression of GSTT1 mRNA	18648102
C027562	4-nitrobenzyl chloride	GSTT1 protein affects the metabolism of 4-nitrobenzyl chloride	15683365
C027562	4-nitrobenzyl chloride	GSTT1 protein results in increased glutathionylation of 4-nitrobenzyl chloride	19664997
C027562	4-nitrobenzyl chloride	GSTT1 protein results in increased metabolism of 4-nitrobenzyl chloride	23505503
C027562	4-nitrobenzyl chloride	GSTT1 protein affects the metabolism of 4-nitrobenzyl chloride	9854036
C027562	4-nitrobenzyl chloride	GSTT1 protein affects the metabolism of 4-nitrobenzyl chloride	1848757
C110057	4-nitrophenethyl bromide	GSTT1 protein affects the metabolism of 4-nitrophenethyl bromide	15683365
C110057	4-nitrophenethyl bromide	GSTT1 protein affects the metabolism of 4-nitrophenethyl bromide	1848757
C522589	5,6-dihydrocyclopenta-1,2-dithiole-3-thione	5,6-dihydrocyclopenta-1,2-dithiole-3-thione results in increased expression of GSTT1 mRNA	19695238
C057269	6-aminochrysene-1,2-dihydrodiol	GSTT1 protein affects the metabolism of and results in decreased activity of 6-aminochrysene-1,2-dihydrodiol metabolite	8951341
C453681	7-amino-4-chloromethylcoumarin	GSTT1 protein mutant form results in increased metabolism of 7-amino-4-chloromethylcoumarin	17011574
C008450	7-methylguanine	GSTT1 gene polymorphism affects the susceptibility to and affects the metabolism of 7-methylguanine	15066569
D000082	Acetaminophen	Acetaminophen results in increased expression of GSTT1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of GSTT1 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of GSTT1 mRNA	17585979
D000082	Acetaminophen	[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GSTT1 protein	25499718
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GSTT1 mRNA]	17585979
D020106	Acrylamide	[CYP2E1 gene polymorphism co-treated with GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Acrylamide	19131562
D020106	Acrylamide	GSTT1 gene polymorphism affects the metabolism of Acrylamide	19131562
D020106	Acrylamide	Acrylamide results in increased expression of GSTT1 mRNA	28959563
D000336	Aerosols	Aerosols results in increased expression of GSTT1 mRNA	29501877
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of GSTT1 mRNA	22100608; 27153756;
D016604	Aflatoxin B1	GSTT1 gene SNP affects the susceptibility to Aflatoxin B1	12907637
D016604	Aflatoxin B1	GSTT1 protein affects the metabolism of and results in decreased activity of Aflatoxin B1 metabolite	8951341
D000393	Air Pollutants	GSTT1 gene polymorphism affects the susceptibility to Air Pollutants	22732554
C038491	allyl sulfide	allyl sulfide results in increased expression of GSTT1 mRNA	19695238
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of GSTT1 mRNA	28522335
D024502	alpha-Tocopherol	alpha-Tocopherol results in increased expression of GSTT1 protein	9855024
D000638	Amiodarone	Amiodarone affects the expression of GSTT1 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GSTT1 mRNA	16483693
D000666	Amphotericin B	Amphotericin B results in decreased expression of GSTT1 mRNA	20623750
C019257	angelica lactone	angelica lactone results in increased expression of GSTT1 protein	9855024
D000975	Antioxidants	GSTT1 gene mutant form results in increased abundance of Antioxidants	25420021
C000228	aristolochic acid I	aristolochic acid I results in increased expression of GSTT1 mRNA	17483316
D001151	Arsenic	Arsenic affects the methylation of GSTT1 gene	25304211
D001151	Arsenic	GSTT1 gene affects the susceptibility to Arsenic	17284320
D001151	Arsenic	GSTT1 gene polymorphism affects the methylation of Arsenic	24511153; 25876999;
D001151	Arsenic	GSTT1 gene polymorphism affects the susceptibility to Arsenic	16214926
D001151	Arsenic	GSTT1 gene SNP affects the metabolism of Arsenic	27327299
D001151	Arsenic	GSTT1 mutant form affects the metabolism of Arsenic	22136492
D001152	Arsenicals	GSTT1 gene polymorphism affects the abundance of and affects the methylation of Arsenicals	27084675
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of GSTT1 mRNA	20458559
C015001	arsenite	arsenite results in increased expression of GSTT1 mRNA	15345372
D001194	Asbestos	GSTT1 gene polymorphism affects the susceptibility to Asbestos	20847076
D001194	Asbestos	GSTT1 protein affects the susceptibility to Asbestos	17563610
D001205	Ascorbic Acid	GSTT1 affects the susceptibility to Ascorbic Acid deficiency	19710200
D001241	Aspirin	Aspirin results in increased expression of GSTT1 protein	9729437
D001280	Atrazine	Atrazine affects the expression of GSTT1 mRNA	22236720
D001280	Atrazine	[Atrazine co-treated with Chlorpyrifos] results in decreased expression of GSTT1 mRNA	22236720
D001280	Atrazine	[Atrazine co-treated with Chlorpyrifos] results in increased expression of GSTT1 mRNA	22236720
D001280	Atrazine	Atrazine results in decreased expression of GSTT1 mRNA	22236720
D001280	Atrazine	Atrazine results in decreased expression of GSTT1 mRNA	22982499
C547126	AZM551248	AZM551248 results in decreased expression of GSTT1 mRNA	22323515
D001553	Benzbromarone	Benzbromarone affects the expression of GSTT1 mRNA	19483382
D001554	Benzene	GSTM1 gene polymorphism affects the reaction [GSTT1 gene polymorphism affects the reaction [NQO1 gene SNP results in increased susceptibility to Benzene]]	17178637
D001554	Benzene	GSTT1 gene polymorphism affects the susceptibility to Benzene	15226677; 15256146; 15591089;
D001554	Benzene	GSTT1 gene polymorphism results in increased susceptibility to Benzene	15226677; 15748501; 17119198; 17178637;
D001554	Benzene	GSTT1 gene SNP affects the metabolism of Benzene	30086327
D001554	Benzene	[GSTT1 gene SNP affects the metabolism of Benzene] which affects the abundance of S-phenyl-N-acetylcysteine	30086327
D001554	Benzene	GSTT1 polymorphism affects the susceptibility to Benzene	18836923
D001554	Benzene	GSTT1 protein affects the metabolism of Benzene	15226677
D001554	Benzene	GSTT1 protein affects the susceptibility to Benzene	12460800; 29204680;
D001554	Benzene	GSTT1 protein polymorphism affects the chemical synthesis of Benzene metabolite	15935803
D001554	Benzene	GSTT1 protein polymorphism affects the metabolism of [Benzene co-treated with Glutathione]	15533900
D001554	Benzene	GSTT1 protein polymorphism affects the susceptibility to Benzene	15533900; 15935803;
D001554	Benzene	GSTT1 protein results in increased metabolism of Benzene	17885617
D001554	Benzene	GSTT1 gene polymorphism affects the susceptibility to Benzene	18848868
C023372	benzene oxide	GSTT1 protein results in increased metabolism of benzene oxide	26554337
C023372	benzene oxide	GSTT1 protein affects the metabolism of benzene oxide	22153878
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GSTT1 mRNA	22228805
D001564	Benzo(a)pyrene	[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of GSTT1 mRNA	28987381
C031403	benzyl isothiocyanate	benzyl isothiocyanate results in increased expression of GSTT1 protein	9794803
C044887	beta-methylcholine	beta-methylcholine affects the expression of GSTT1 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of GSTT1 mRNA	30903817
C006780	bisphenol A	bisphenol A results in increased expression of GSTT1 mRNA	25181051
C032036	bromobenzene	bromobenzene results in decreased expression of GSTT1 mRNA	15056800
C025191	bromodichloromethane	GSTT1 protein results in increased metabolism of bromodichloromethane	12588193
C025191	bromodichloromethane	GSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione]	14998683
D002066	Busulfan	[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan	21215809
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GSTT1 mRNA	9794803
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GSTT1 protein	9794803
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in increased expression of GSTT1 mRNA	15110098
D002087	Butyrates	Butyrates results in increased expression of GSTT1 mRNA	14674679
D002101	Cacodylic Acid	GSTT1 gene affects the susceptibility to Cacodylic Acid	17431481
D002101	Cacodylic Acid	GSTT1 protein affects the metabolism of Cacodylic Acid	17431481
D002104	Cadmium	Cadmium affects the expression of GSTT1 mRNA	21276481
D002104	Cadmium	Cadmium results in decreased expression of GSTT1 mRNA	22257444
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of GSTT1 promoter	22457795
D002220	Carbamazepine	Carbamazepine affects the expression of GSTT1 mRNA	24752500
D002246	Carbon Disulfide	GSTT1 gene polymorphism affects the metabolism of Carbon Disulfide	17333241
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of GSTT1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GSTT1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GSTT1 mRNA	31150632
D002251	Carbon Tetrachloride	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTT1 mRNA]	31150632
D002330	Carmustine	GSTT1 protein affects the susceptibility to Carmustine	16874663
D002330	Carmustine	GSTT1 protein results in decreased nitrosation of Carmustine	11841793
D002330	Carmustine	GSTT1 protein affects the metabolism of Carmustine	17827337
D004390	Chlorpyrifos	[Atrazine co-treated with Chlorpyrifos] results in decreased expression of GSTT1 mRNA	22236720
D004390	Chlorpyrifos	[Atrazine co-treated with Chlorpyrifos] results in increased expression of GSTT1 mRNA	22236720
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of GSTT1 mRNA	22236720
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of GSTT1 mRNA	22236720
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of GSTT1 mRNA	24581378
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of GSTT1 protein	24581378
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of GSTT1 mRNA	17452286; 19440498;
C012843	cinnamic aldehyde	cinnamic aldehyde affects the expression of GSTT1 mRNA	28219650
D002945	Cisplatin	GSTT1 gene polymorphism affects the susceptibility to [Paclitaxel co-treated with Cisplatin]	12851839
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of GSTT1 mRNA	17585979
D002994	Clofibrate	Clofibrate results in increased expression of GSTT1 mRNA	18723825
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GSTT1 mRNA]	17585979
D002994	Clofibrate	Clofibrate affects the expression of GSTT1 mRNA	19483382
D002994	Clofibrate	Clofibrate results in increased expression of GSTT1 mRNA	12883083
D060729	Coal Ash	GSTT1 polymorphism affects the susceptibility to Coal Ash	21334974
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of GSTT1 mRNA	24386269
D003069	Coffee	Coffee affects the expression of GSTT1 mRNA	21448860
D003300	Copper	Copper results in increased expression of GSTT1 mRNA	25646894
D003300	Copper	Copper results in decreased expression of GSTT1 mRNA	22465980
C030123	coumarin	coumarin results in increased expression of GSTT1 mRNA	10413528; 9794803;
C030123	coumarin	coumarin results in increased expression of GSTT1 protein	10413528; 9794803; 9855024;
C007164	cumene hydroperoxide	GSTT1 protein affects the oxidation of cumene hydroperoxide	19664997
C007164	cumene hydroperoxide	GSTT1 protein affects the metabolism of cumene hydroperoxide	9854036
C007164	cumene hydroperoxide	GSTT1 protein affects the metabolism of cumene hydroperoxide	1848757
D003471	Cuprizone	Cuprizone results in increased expression of GSTT1 mRNA	26577399
C057862	cyanoginosin LR	GSTT1 protein results in increased glutathionylation of and affects the susceptibility to cyanoginosin LR	21504230
D016572	Cyclosporine	Cyclosporine results in decreased expression of GSTT1 mRNA	20106945; 23830897; 25562108;
D016572	Cyclosporine	Cyclosporine results in decreased expression of GSTT1 mRNA	19770486; 23308384; 23830897;
C089595	cylindrospermopsin	cylindrospermopsin results in decreased expression of GSTT1 mRNA	20936652
C093628	cyproconazole	cyproconazole results in increased expression of GSTT1 mRNA	22334560
C017180	decamethrin	[decamethrin results in decreased susceptibility to decamethrin] which results in decreased expression of GSTT1	26588704
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in increased expression of GSTT1 mRNA	17823450
D064791	Desoxycorticosterone Acetate	[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GSTT1 mRNA	22228705
D003907	Dexamethasone	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GSTT1 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in decreased expression of GSTT1 mRNA	12971794
D003976	Diazinon	Diazinon results in increased expression of GSTT1 mRNA	17452286
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased expression of GSTT1 mRNA	29554563
D004008	Diclofenac	Diclofenac affects the activity of GSTT1 protein	27183920
D004008	Diclofenac	Diclofenac affects the expression of GSTT1 mRNA	24752500
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of GSTT1 mRNA	26924002
C007366	diepoxybutane	GSTT1 gene polymorphism affects the susceptibility to diepoxybutane	12694746; 15036125;
C007366	diepoxybutane	GSTT1 gene polymorphism results in increased susceptibility to diepoxybutane	17078101
C007366	diepoxybutane	GSTT1 protein affects the metabolism of and results in increased activity of diepoxybutane	8565128
C007366	diepoxybutane	GSTT1 protein results in decreased activity of diepoxybutane	12694746
C007366	diepoxybutane	GSTT1 protein affects the metabolism of and results in increased activity of diepoxybutane	7578934
C014476	diethyl maleate	diethyl maleate results in increased expression of GSTT1 protein	9794803
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of GSTT1 mRNA	27638505
C024629	dimethyl phthalate	dimethyl phthalate results in decreased expression of GSTT1 mRNA	26924002
D004137	Dinitrochlorobenzene	GSTT1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]	15950511
D004137	Dinitrochlorobenzene	GSTT1 protein results in increased metabolism of Dinitrochlorobenzene	23505503
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in decreased expression of GSTT1 mRNA	28219650
D004610	Ellagic Acid	Ellagic Acid affects the expression of GSTT1 protein	9855024
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of GSTT1 mRNA	24534155
C109476	epoxiconazole	epoxiconazole results in increased expression of GSTT1 mRNA	22334560
D004958	Estradiol	Estradiol results in decreased expression of GSTT1 mRNA	23019147
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of GSTT1 mRNA	17404688
D004958	Estradiol	Estradiol results in decreased expression of GSTT1 mRNA	14664709
D002393	Estrogens, Catechol	GSTT1 protein affects the metabolism of Estrogens, Catechol metabolite	15455371
D004976	Ethacrynic Acid	Ethacrynic Acid results in decreased activity of GSTT1 protein	23505503
D000431	Ethanol	GSTT1 gene polymorphism affects the susceptibility to Ethanol	15932176
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of GSTT1 mRNA	23129252
D005001	Ethionine	Ethionine affects the expression of GSTT1 mRNA	19483382
D005015	Ethoxyquin	Ethoxyquin results in increased expression of GSTT1 mRNA	18723825
D005015	Ethoxyquin	Ethoxyquin results in increased expression of GSTT1 mRNA	9794803
D005015	Ethoxyquin	Ethoxyquin results in increased expression of GSTT1 protein	9794803
D015946	Ethylene Dibromide	GSTT1 gene SNP inhibits the reaction [GSTT1 protein results in increased glutathionylation of Ethylene Dibromide]	21781954; 21781954;
D015946	Ethylene Dibromide	GSTT1 protein affects the metabolism of and results in increased activity of Ethylene Dibromide	8565128
D015946	Ethylene Dibromide	GSTT1 protein results in increased activity of Ethylene Dibromide	19664997
D015946	Ethylene Dibromide	GSTT1 protein results in increased glutathionylation of Ethylene Dibromide	21781954
D015946	Ethylene Dibromide	GSTT1 protein affects the susceptibility to Ethylene Dibromide	12902151
D015946	Ethylene Dibromide	GSTT1 protein results in increased activity of Ethylene Dibromide	12505322
D015946	Ethylene Dibromide	GSTT1 protein results in increased metabolism of and results in increased activity of Ethylene Dibromide	10413528
C002994	ethylene dimethanesulfonate	ethylene dimethanesulfonate results in decreased expression of GSTT1 mRNA	22711419
D005027	Ethylene Oxide	GSTT1 protein affects the abundance of Ethylene Oxide metabolite	17416773
D005038	Ethylnitrosourea	GSTT1 gene polymorphism affects the susceptibility to Ethylnitrosourea	17158087
D017313	Fenretinide	Fenretinide results in decreased expression of GSTT1 mRNA	16467112
D005472	Fluorouracil	Fluorouracil results in increased expression of GSTT1 protein	15585135; 16803524;
D005557	Formaldehyde	[GSTT1 protein affects the metabolism of Methylene Chloride] which results in increased abundance of Formaldehyde	16765633
C039281	furan	furan results in increased methylation of GSTT1 gene	22079235
D005938	Glucocorticoids	GSTT1 gene polymorphism affects the susceptibility to Glucocorticoids	15457183
D005944	Glucosamine	Glucosamine results in increased expression of GSTT1 mRNA	17178593
D005978	Glutathione	GSTT1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]	15950511
D005978	Glutathione	GSTT1 protein affects the metabolism of Glutathione	14727918
D005978	Glutathione	GSTT1 protein polymorphism affects the metabolism of [Benzene co-treated with Glutathione]	15533900
D005978	Glutathione	GSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione]	14998683
C071834	glycidamide	[CYP2E1 gene polymorphism co-treated with EPHX1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the abundance of glycidamide	19131562
C071834	glycidamide	[CYP2E1 gene polymorphism co-treated with EPHX1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of glycidamide	19131562
C071834	glycidamide	[CYP2E1 gene polymorphism co-treated with GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the abundance of glycidamide	19131562
C071834	glycidamide	GSTT1 gene polymorphism affects the abundance of glycidamide	19131562
D006016	Glycolates	Glycolates analog binds to and results in decreased activity of GSTT1 protein	6686184
D006108	Graphite	Graphite affects the expression of GSTT1 mRNA	29933104
D006540	Herbicides	Herbicides binds to and results in decreased activity of GSTT1 protein	6686184
D006843	Hydrocarbons, Chlorinated	GSTT1 gene polymorphism affects the susceptibility to Hydrocarbons, Chlorinated	26479327
D006846	Hydrocarbons, Halogenated	GSTT1 protein affects the metabolism of and results in increased activity of Hydrocarbons, Halogenated	11511186
D006846	Hydrocarbons, Halogenated	GSTT1 protein affects the metabolism of Hydrocarbons, Halogenated	8625454
D006861	Hydrogen Peroxide	[HP gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Hydrogen Peroxide	20444272
D007052	Ibuprofen	Ibuprofen results in increased expression of GSTT1 protein	9729437
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of GSTT1 mRNA	21396975
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of GSTT1 mRNA	10413528; 9794803;
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of GSTT1 protein	10413528; 9794803;
D007213	Indomethacin	Indomethacin results in increased expression of GSTT1 protein	9729437
D007306	Insecticides	GSTT1 gene polymorphism affects the susceptibility to Insecticides	12930676
D007306	Insecticides	GSTT1 protein affects the metabolism of and results in decreased alkylation of Insecticides	15103050
D007538	Isoniazid	GSTT1 gene polymorphism affects the susceptibility to [Isoniazid co-treated with Rifampin]	20485159
D007538	Isoniazid	GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide]	18397238
D017879	Isothiocyanates	GSTT1 gene polymorphism affects the susceptibility to Isothiocyanates	14693750
C098607	JP8 aviation fuel	GSTT1 gene affects the susceptibility to JP8 aviation fuel	21961652
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of GSTT1 mRNA	12832151
C410337	K 7174	K 7174 results in decreased expression of GSTT1 mRNA	24086573
D007854	Lead	[GSTM1 gene mutant form co-treated with GSTT1 gene mutant form] promotes the reaction [Lead results in increased expression of CRP protein]	23484121
D007854	Lead	[GSTM1 gene mutant form co-treated with GSTT1 gene mutant form] results in increased susceptibility to Lead	23484121
D007854	Lead	GSTT1 gene mutant form promotes the reaction [Lead results in increased expression of CRP protein]	23484121
D007854	Lead	GSTT1 gene mutant form results in increased susceptibility to Lead	23484121
D007854	Lead	GSTT1 gene polymorphism affects the abundance of Lead	25728017
D007854	Lead	Lead results in decreased expression of GSTT1 mRNA	19921347
C017461	lead nitrate	lead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]	11891201
C017461	lead nitrate	lead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]	11891201
D008054	Lipid Peroxides	GSTT1 protein affects the metabolism of and results in decreased susceptibility to Lipid Peroxides	9576856
C482199	lipopolysaccharide, E coli O55-B5	[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of GSTT1 mRNA	28987381
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of GSTT1 mRNA	24001438
D008070	Lipopolysaccharides	Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of GSTT1 mRNA]	24001438
D008315	Malondialdehyde	GSTT1 gene polymorphism affects the abundance of Malondialdehyde	25728017
C033266	Menhaden oil	Menhaden oil promotes the reaction [Polycyclic Aromatic Hydrocarbons results in increased expression of GSTT1 mRNA]	22066002
C033266	Menhaden oil	Menhaden oil results in increased expression of GSTT1 mRNA	22066002
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of GSTT1 mRNA	20353558
D008628	Mercury	[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Mercury	24319713
D008628	Mercury	GSTT1 gene polymorphism affects the abundance of Mercury	21967774
D008628	Mercury	GSTT1 gene polymorphism affects the susceptibility to Mercury	20194072
D008628	Mercury	GSTT1 gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]	19515364
D008628	Mercury	GSTT1 polymorphism affects the susceptibility to Mercury	17716707
D008694	Methamphetamine	GSTT1 gene polymorphism affects the susceptibility to Methamphetamine	18186040
D008694	Methamphetamine	GSTT1 protein affects the susceptibility to Methamphetamine	19254865
D008713	Methimazole	Methimazole results in increased expression of GSTT1 mRNA	22504374
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of GSTT1 mRNA	20864626
C005218	methyl bromide	GSTT1 protein results in increased metabolism of methyl bromide	11305778
D008737	Methyl Chloride	GSTT1 protein polymorphism affects the metabolism of and affects the susceptibility to Methyl Chloride	11218045
D008737	Methyl Chloride	GSTT1 protein results in increased metabolism of Methyl Chloride	11305778
C027947	methylene bromide	GSTT1 protein affects the metabolism of and results in increased activity of methylene bromide	8565128
C027947	methylene bromide	GSTT1 protein affects the metabolism of methylene bromide	14727918
C027947	methylene bromide	GSTT1 protein results in increased metabolism of methylene bromide	30169019
C027947	methylene bromide	GSTT1 protein affects the metabolism of and results in increased activity of methylene bromide	11511186
D008752	Methylene Chloride	GSTT1 gene polymorphism affects the metabolism of Methylene Chloride	7979958
D008752	Methylene Chloride	GSTT1 protein affects the metabolism of Methylene Chloride	14727918; 15683365;
D008752	Methylene Chloride	GSTT1 protein alternative form affects the susceptibility to Methylene Chloride	20837120
D008752	Methylene Chloride	GSTT1 protein results in increased metabolism of Methylene Chloride	11446825; 12054768;
D008752	Methylene Chloride	GSTT1 protein affects the metabolism of and results in increased activity of Methylene Chloride	15683365; 8761485;
D008752	Methylene Chloride	GSTT1 protein affects the metabolism of Methylene Chloride	17827337; 8670055; 9854036;
D008752	Methylene Chloride	[GSTT1 protein affects the metabolism of Methylene Chloride] which results in increased abundance of Formaldehyde	16765633
D008752	Methylene Chloride	GSTT1 protein affects the metabolism of Methylene Chloride	1848757; 8670055;
D008752	Methylene Chloride	GSTT1 protein affects the metabolism of Methylene Chloride	14727918
D008752	Methylene Chloride	GSTT1 protein results in increased metabolism of and results in increased activity of Methylene Chloride	10413528
D008752	Methylene Chloride	GSTT1 protein results in increased metabolism of Methylene Chloride	11453994
D008752	Methylene Chloride	GSTT1 protein results in increased metabolism of Methylene Chloride	20837120
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GSTT1 mRNA	23103053
D008743	Methyl Parathion	GSTT1 protein affects the metabolism of and results in decreased alkylation of Methyl Parathion	15103050
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of GSTT1 mRNA	24128854
C063855	microcystin RR	GSTT1 protein results in increased glutathionylation of microcystin RR	23538035
D052998	Microcystins	Microcystins affects the expression of GSTT1 mRNA	19790251
D052998	Microcystins	Microcystins results in increased expression of GSTT1 mRNA	19790251
C000627226	momfluorothrin	momfluorothrin results in increased expression of GSTT1 mRNA	28520973
C020300	monomethylarsonic acid	GSTT1 protein affects the methylation of monomethylarsonic acid	17431481
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of GSTT1 mRNA	26924002
C005939	muconic acid	GSTT1 affects the abundance of muconic acid	10780264
C058346	N-(4-methoxyphenyl)retinamide	N-(4-methoxyphenyl)retinamide results in decreased expression of GSTT1 mRNA	16467112
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of GSTT1 mRNA	25554681; 25620056;
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of GSTT1 mRNA	25554681
C031721	naphthalene	naphthalene results in decreased expression of GSTT1 mRNA	31020322
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of GSTT1 mRNA	19812364
D009532	Nickel	Nickel results in decreased expression of GSTT1 mRNA	24768652
C022838	nickel chloride	nickel chloride results in decreased expression of GSTT1 mRNA	12729255; 14645679;
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of GSTT1 mRNA	12729255
D009585	Nitrogen Dioxide	GSTT1 gene polymorphism affects the susceptibility to Nitrogen Dioxide	22732554
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with Pioglitazone] results in decreased expression of GSTT1 mRNA	27935865
C464660	obeticholic acid	obeticholic acid results in increased expression of GSTT1 mRNA	27939613
C025589	ochratoxin A	ochratoxin A results in decreased expression of GSTT1 mRNA	23358140
C026209	oltipraz	oltipraz affects the localization of GSTT1 protein	10413528; 9794803;
C026209	oltipraz	oltipraz results in increased expression of GSTT1 protein	9794803; 9855024;
D009853	Omeprazole	Omeprazole affects the expression of GSTT1 mRNA	19483382
C002771	Omite	GSTT1 gene mutant form results in increased susceptibility to Omite	30446643
C016340	o,p'-DDT	o,p'-DDT affects the expression of GSTT1 mRNA	17984292
D010755	Organophosphates	GSTT1 gene polymorphism affects the susceptibility to Organophosphates	26318115
D010126	Ozone	GSTT1 gene polymorphism affects the susceptibility to Ozone	22732554
D017239	Paclitaxel	GSTT1 gene polymorphism affects the susceptibility to [Paclitaxel co-treated with Cisplatin]	12851839
D010269	Paraquat	GSTT1 protein affects the susceptibility to Paraquat	23045187
D052638	Particulate Matter	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of GSTT1 mRNA]	28655636
D052638	Particulate Matter	GSTT1 gene polymorphism affects the susceptibility to Particulate Matter	22732554
D052638	Particulate Matter	Particulate Matter results in decreased expression of GSTT1 mRNA	28655636
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of GSTT1 mRNA	19162173
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of GSTT1 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of GSTT1 mRNA	19429403
D010575	Pesticides	GSTT1 affects the susceptibility to Pesticides	26656529
D010575	Pesticides	GSTT1 gene polymorphism affects the susceptibility to Pesticides	14504370; 15922524; 18550589; 23982010; 27185341;
D010575	Pesticides	GSTT1 protein results in increased susceptibility to Pesticides	18550589
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of GSTT1 protein	9855024
D010634	Phenobarbital	Phenobarbital results in decreased expression of GSTT1 mRNA	19952500
D010634	Phenobarbital	Phenobarbital affects the expression of GSTT1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTT1 mRNA	18723825; 9854036;
D010634	Phenobarbital	Phenobarbital affects the expression of GSTT1 mRNA	19162173
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTT1 mRNA	10413528
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTT1 protein	10413528; 9794803;
D010695	Phlorhizin	Phlorhizin results in decreased expression of GSTT1 mRNA	22538082
D010695	Phlorhizin	Phlorhizin results in increased expression of GSTT1 mRNA	22538082
D000077205	Pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with Pioglitazone] results in decreased expression of GSTT1 mRNA	27935865
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GSTT1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid affects the expression of GSTT1 mRNA	19483382
D010894	Piroxicam	Piroxicam results in increased expression of GSTT1 protein	9729437
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of GSTT1 mRNA]	24001438
D028321	Plant Preparations	GSTT1 gene polymorphism affects the susceptibility to Plant Preparations	17602170
D017671	Platinum Compounds	GSTT1 affects the susceptibility to Platinum Compounds	21844884
D011084	Polycyclic Aromatic Hydrocarbons	GSTT1 gene polymorphism affects the susceptibility to Polycyclic Aromatic Hydrocarbons	12807751
D011084	Polycyclic Aromatic Hydrocarbons	GSTT1 protein affects the metabolism of and results in decreased activity of Polycyclic Aromatic Hydrocarbons	15122594
D011084	Polycyclic Aromatic Hydrocarbons	GSTT1 protein results in decreased activity of Polycyclic Aromatic Hydrocarbons	15122594
D011084	Polycyclic Aromatic Hydrocarbons	Menhaden oil promotes the reaction [Polycyclic Aromatic Hydrocarbons results in increased expression of GSTT1 mRNA]	22066002
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons results in increased expression of GSTT1 mRNA	22066002
D011189	Potassium Chloride	[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GSTT1 mRNA	22228705
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of GSTT1 mRNA	18332044
D011374	Progesterone	Progesterone results in decreased expression of GSTT1 mRNA	23018184
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of GSTT1 mRNA	17404688
C045950	propiconazole	propiconazole results in increased expression of GSTT1 mRNA	22334560
D011441	Propylthiouracil	Propylthiouracil affects the expression of GSTT1 mRNA	19483382
D011441	Propylthiouracil	Propylthiouracil results in increased expression of GSTT1 mRNA	22504374; 24780913;
D011718	Pyrazinamide	GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide]	18397238
C031280	pyrazole	pyrazole results in decreased expression of GSTT1 mRNA	17945193
D011794	Quercetin	Quercetin results in decreased expression of GSTT1 protein	22830632
D011794	Quercetin	Quercetin results in decreased expression of GSTT1 mRNA	16455785
D012293	Rifampin	GSTT1 gene polymorphism affects the susceptibility to [Isoniazid co-treated with Rifampin]	20485159
D012293	Rifampin	GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide]	18397238
D000077154	Rosiglitazone	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GSTT1 mRNA	16054899
D000077154	Rosiglitazone	Rosiglitazone affects the expression of GSTT1 mRNA	17245590
C541923	sandostatinLAR	sandostatinLAR results in decreased expression of GSTT1 mRNA	17210224
C015499	schizandrin B	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTT1 mRNA]	31150632
D012643	Selenium	Selenium deficiency results in increased expression of GSTT1	9331086
C009237	senecionine	senecionine results in decreased expression of GSTT1 mRNA	26100227
C058186	S-hexylglutathione-sepharose	S-hexylglutathione-sepharose binds to GSTT1 protein	2337594
D012834	Silver	Silver results in increased expression of GSTT1 mRNA	21276481
D020123	Sirolimus	GSTT1 gene mutant form results in increased susceptibility to Sirolimus	12916871
C017947	sodium arsenite	sodium arsenite affects the expression of GSTT1 mRNA	16507464
C017947	sodium arsenite	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTT1 mRNA	16368122
C017947	sodium arsenite	sodium arsenite results in decreased expression of GSTT1 mRNA	29108910
C017947	sodium arsenite	sodium arsenite results in increased expression of GSTT1 mRNA	17451858
C016104	sodium bichromate	sodium bichromate results in increased expression of GSTT1 mRNA	12325037
D017673	Sodium Chloride, Dietary	[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GSTT1 mRNA	22228705
D012982	Sodium, Dietary	GSTT1 gene polymorphism affects the susceptibility to Sodium, Dietary	14696128
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GSTT1 mRNA	16705456; 24383545;
D012997	Solvents	GSTT1 polymorphism affects the susceptibility to Solvents	24914957
D053260	Soot	Soot results in decreased expression of GSTT1 mRNA	23065132
C053003	S-phenyl-N-acetylcysteine	GSTT1 gene polymorphism affects the abundance of S-phenyl-N-acetylcysteine	20100551
C053003	S-phenyl-N-acetylcysteine	GSTT1 gene polymorphism affects the reaction [GSTM1 gene polymorphism affects the abundance of S-phenyl-N-acetylcysteine]	20100551
C053003	S-phenyl-N-acetylcysteine	[GSTT1 gene SNP affects the metabolism of Benzene] which affects the abundance of S-phenyl-N-acetylcysteine	30086327
C053003	S-phenyl-N-acetylcysteine	GSTT1 polymorphism affects the abundance of S-phenyl-N-acetylcysteine	21300142
C053003	S-phenyl-N-acetylcysteine	GSTT1 protein polymorphism affects the chemical synthesis of S-phenyl-N-acetylcysteine	15533900; 15935803;
D013241	Sterigmatocystin	GSTT1 protein affects the metabolism of and results in decreased activity of Sterigmatocystin metabolite	8951341
C025906	stilbene oxide	stilbene oxide results in increased expression of GSTT1 protein	9794803
D020058	Styrene	GSTM1 gene polymorphism promotes the reaction [GSTT1 gene polymorphism results in increased susceptibility to Styrene]	12016165
D020058	Styrene	GSTT1 gene polymorphism affects the susceptibility to Styrene	12717779; 14751678;
D020058	Styrene	GSTT1 gene polymorphism results in increased susceptibility to Styrene	12016165; 16424821;
C013690	styrene oxide	GSTT1 gene polymorphism results in increased susceptibility to styrene oxide	12016165
C013690	styrene oxide	GSTT1 protein affects the susceptibility to styrene oxide	15468052
C016766	sulforafan	sulforafan results in decreased expression of GSTT1 mRNA	20442190
C016766	sulforafan	[NFE2L2 protein affects the susceptibility to sulforafan] which affects the expression of GSTT1 mRNA	30529165
C016766	sulforafan	sulforafan analog results in increased expression of GSTT1 protein	9855024
D013457	Sulfur Compounds	GSTT1 gene polymorphism affects the susceptibility to Sulfur Compounds	15033463
D013467	Sulindac	Sulindac results in increased expression of GSTT1 protein	9729437
C446685	systhane	systhane results in increased expression of GSTT1 mRNA	16730040
D013605	T-2 Toxin	T-2 Toxin results in increased expression of GSTT1 mRNA	31299295
D020122	tert-Butylhydroperoxide	GSTT1 protein affects the metabolism of tert-Butylhydroperoxide	9854036
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of GSTT1 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GSTT1 mRNA	11272835
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of GSTT1 mRNA]	22496397
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GSTT1 mRNA	22496397
D013755	Tetradecanoylphorbol Acetate	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTT1 mRNA	16368122
D013827	Thiabendazole	Thiabendazole results in increased expression of GSTT1 mRNA	15110098
D013849	Thimerosal	GSTT1 affects the susceptibility to Thimerosal	11007341
D013849	Thimerosal	Thimerosal results in decreased expression of GSTT1 mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of GSTT1 mRNA	19483382
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of GSTT1 mRNA	29501877
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of GSTT1 mRNA	29505817
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased susceptibility to GSTT1 protein polymorphism	23643483
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of GSTT1 mRNA	20133372
C032910	triadimefon	triadimefon results in increased expression of GSTT1 mRNA	16730040
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of GSTT1 mRNA	19448997
D014260	Triclosan	Triclosan results in decreased expression of GSTT1 protein	30219713
D022882	Trihalomethanes	GSTT1 affects the susceptibility to Trihalomethanes	20675267
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of GSTT1 mRNA	21346803
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GSTT1 mRNA	26179874
D014315	Triterpenes	Triterpenes results in increased expression of GSTT1 mRNA	18544911
D000077288	Troglitazone	GSTT1 gene polymorphism affects the susceptibility to Troglitazone	12732844
D014415	Tunicamycin	Tunicamycin results in decreased expression of GSTT1 mRNA	17127020
D014527	Uric Acid	GSTT1 protein polymorphism affects the abundance of Uric Acid	23747713
D014635	Valproic Acid	Valproic Acid affects the expression of GSTT1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of GSTT1 mRNA	23179753; 29154799;
D001335	Vehicle Emissions	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of GSTT1 mRNA]	28655636
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of GSTT1 mRNA	28655636
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GSTT1 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions analog results in increased expression of GSTT1 mRNA	15541757
C025643	vinclozolin	vinclozolin results in decreased expression of GSTT1 mRNA	23034163
C025643	vinclozolin	vinclozolin results in increased expression of GSTT1 mRNA	22570695
D014752	Vinyl Chloride	[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] results in increased susceptibility to Vinyl Chloride	16977343
D014752	Vinyl Chloride	GSTT1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]	16097394
D014752	Vinyl Chloride	GSTT1 gene polymorphism results in increased susceptibility to Vinyl Chloride	16270392
C104536	xanthohumol	xanthohumol results in increased expression of GSTT1 mRNA	23085367
C104536	xanthohumol	xanthohumol results in increased expression of GSTT1 protein	23085367
C016837	zinc chloride	zinc chloride results in increased expression of GSTT1 mRNA	19683351

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0025	Alternative splicing
KW-0963	Cytoplasm
KW-0903	Direct protein sequencing
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0808	Transferase

Interpro

InterPro ID	InterPro Term
IPR010987	Glutathione-S-Trfase_C-like
IPR036282	Glutathione-S-Trfase_C_sf
IPR040079	Glutathione_S-Trfase
IPR004045	Glutathione_S-Trfase_N
IPR004046	GST_C
IPR040077	GST_C_Theta
IPR040075	GST_N_Theta
IPR036249	Thioredoxin-like_sf

PROSITE

PROSITE ID	PROSITE Term
PS50405	GST_CTER
PS50404	GST_NTER

Pfam

Pfam ID	Pfam Term
PF00043	GST_C
PF13417	GST_N_3

Gene: GSTT1

Basic information

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction