| Tag | Content |
|---|---|
| Uniprot ID | P31947; Q6FH30; Q6FH51; Q96DH0; |
| Entrez ID | 2810 |
| Genbank protein ID | CAA40623.1; AAH23552.1; AAH00329.1; CAG46703.1; AAC52029.1; AAH02995.1; AAH00995.1; AAC52030.1; CAG46724.1; AAH01550.1; AAA59546.1; |
| Genbank nucleotide ID | NM_006142.3 |
| Ensembl protein ID | ENSP00000340989 |
| Ensembl nucleotide ID | ENSG00000175793 |
| Gene name | 14-3-3 protein sigma |
| Gene symbol | SFN |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. |
| Sequence | MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR 60 VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY 120 LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH 180 YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG 240 EAPQEPQS 248 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.