Gene: CTNNB1

Basic information

Tag Content
Uniprot ID P35222; A8K1L7; Q8NEW9; Q8NI94; Q9H391;
Entrez ID 1499
Genbank protein ID AAG35511.1; BAB93475.1; BAF82621.1; CAA61107.1; AAH58926.1; AAR18817.1; EAW64625.1; CAA79497.1; AAL89457.1;
Genbank nucleotide ID XM_005264886.2; XM_017005738.1; NM_001904.3; NM_001098209.1; NM_001098210.1;
Ensembl protein ID ENSP00000494053; ENSP00000385604; ENSP00000494411; ENSP00000401599; ENSP00000412219; ENSP00000495450; ENSP00000494845; ENSP00000409302; ENSP00000495992; ENSP00000494914; ENSP00000493610; ENSP00000379488; ENSP00000344456; ENSP00000494677; ENSP00000495076; ENSP00000495360; ENSP00000496180; ENSP00000495244; ENSP00000387455; ENSP00000379486; ENSP00000493533; ENSP00000495719; ENSP00000496385; ENSP00000496021;
Ensembl nucleotide ID ENSG00000168036
Gene name Catenin beta-1
Gene symbol CTNNB1
Organism Homo sapiens
NCBI taxa ID 9606
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity).
Sequence
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTS 60
QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT 120
NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 180
KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 240
VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 300
LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA 360
GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 420
AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 480
AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 540
VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV 600
QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 660
RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEPLGYR QDDPSYRSFH 720
SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD 780
L 781

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database


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Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCTNNB1539003Q0VCX4Bos taurusPredictionMore>>
1:1 orthologCTNNB1477032B6V8E6Canis lupus familiarisPredictionMore>>
1:1 orthologCTNNB1102191742A0A2Z4FR65Capra hircusPredictionMore>>
1:1 orthologCTNNB1100055241B1MV73Equus caballusPredictionMore>>
1:1 orthologCTNNB11499P35222Homo sapiensPredictionMore>>
1:1 orthologCtnnb112387Q02248CPO,CLPE14.5Mus musculusPublicationMore>>
1:1 orthologCTNNB1450183A0A2I3SBG5Pan troglodytesPredictionMore>>
1:1 orthologCtnnb184353A0A0G2JT93Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Disease or phenotype associated information

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0001085 RNA polymerase II transcription factor bindingIDA
GO:0001085 RNA polymerase II transcription factor bindingIPI
GO:0001102 RNA polymerase II activating transcription factor bindingIPI
GO:0003682 chromatin bindingISS
GO:0003700 DNA-binding transcription factor activityIEA
GO:0003713 transcription coactivator activityIDA
GO:0003713 transcription coactivator activityIMP
GO:0003713 transcription coactivator activityIBA
GO:0005515 protein bindingIPI
GO:0008013 beta-catenin bindingIPI
GO:0008022 protein C-terminus bindingIPI
GO:0008134 transcription factor bindingIPI
GO:0008134 transcription factor bindingTAS
GO:0019899 enzyme bindingIPI
GO:0019900 kinase bindingIPI
GO:0019901 protein kinase bindingIEA
GO:0019903 protein phosphatase bindingIPI
GO:0019903 protein phosphatase bindingIBA
GO:0030331 estrogen receptor bindingIPI
GO:0035257 nuclear hormone receptor bindingIPI
GO:0035257 nuclear hormone receptor bindingTAS
GO:0035257 nuclear hormone receptor bindingIBA
GO:0044325 ion channel bindingIPI
GO:0045294 alpha-catenin bindingIBA
GO:0045294 alpha-catenin bindingIPI
GO:0045296 cadherin bindingIPI
GO:0045296 cadherin bindingIBA
GO:0045296 cadherin bindingHDA
GO:0046332 SMAD bindingIPI
GO:0050681 androgen receptor bindingNAS
GO:0070411 I-SMAD bindingIPI
GO:0070491 repressing transcription factor bindingIEA
GO:0097718 disordered domain specific bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIIEA
GO:0000209 protein polyubiquitinationIDA
GO:0000578 embryonic axis specificationIEA
GO:0000904 cell morphogenesis involved in differentiationIEA
GO:0001569 branching involved in blood vessel morphogenesisIC
GO:0001658 branching involved in ureteric bud morphogenesisIEA
GO:0001701 in utero embryonic developmentIEA
GO:0001702 gastrulation with mouth forming secondIEA
GO:0001708 cell fate specificationIEA
GO:0001711 endodermal cell fate commitmentIEA
GO:0001764 neuron migrationIEA
GO:0001837 epithelial to mesenchymal transitionTAS
GO:0001840 neural plate developmentIEA
GO:0002052 positive regulation of neuroblast proliferationISS
GO:0002053 positive regulation of mesenchymal cell proliferationIEA
GO:0002089 lens morphogenesis in camera-type eyeIEA
GO:0003266 regulation of secondary heart field cardioblast proliferationIEA
GO:0003338 metanephros morphogenesisIEA
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisIEA
GO:0007155 cell adhesionIMP
GO:0007160 cell-matrix adhesionIEA
GO:0007223 Wnt signaling pathway, calcium modulating pathwayTAS
GO:0007268 chemical synaptic transmissionIEA
GO:0007398 ectoderm developmentIEA
GO:0007403 glial cell fate determinationIEA
GO:0008285 negative regulation of cell population proliferationIDA
GO:0009948 anterior/posterior axis specificationIEA
GO:0009950 dorsal/ventral axis specificationIEA
GO:0009954 proximal/distal pattern formationIEA
GO:0010718 positive regulation of epithelial to mesenchymal transitionIGI
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic processIMP
GO:0016032 viral processIEA
GO:0016055 Wnt signaling pathwayTAS
GO:0016525 negative regulation of angiogenesisISS
GO:0019827 stem cell population maintenanceTAS
GO:0021819 layer formation in cerebral cortexIEA
GO:0022009 central nervous system vasculogenesisIEA
GO:0030316 osteoclast differentiationIEA
GO:0030521 androgen receptor signaling pathwayNAS
GO:0030539 male genitalia developmentIEA
GO:0030902 hindbrain developmentIEA
GO:0030997 regulation of centriole-centriole cohesionIDA
GO:0031016 pancreas developmentIEA
GO:0031069 hair follicle morphogenesisIEA
GO:0031641 regulation of myelinationIEA
GO:0032212 positive regulation of telomere maintenance via telomeraseIEA
GO:0032331 negative regulation of chondrocyte differentiationIEA
GO:0032355 response to estradiolIDA
GO:0032481 positive regulation of type I interferon productionTAS
GO:0033077 T cell differentiation in thymusIEA
GO:0033234 negative regulation of protein sumoylationIDA
GO:0034333 adherens junction assemblyIMP
GO:0034394 protein localization to cell surfaceIMP
GO:0035050 embryonic heart tube developmentIEA
GO:0035112 genitalia morphogenesisIEA
GO:0035115 embryonic forelimb morphogenesisIEA
GO:0035116 embryonic hindlimb morphogenesisIEA
GO:0035315 hair cell differentiationTAS
GO:0035635 entry of bacterium into host cellTAS
GO:0036023 embryonic skeletal limb joint morphogenesisISS
GO:0036520 astrocyte-dopaminergic neuron signalingIEA
GO:0042129 regulation of T cell proliferationIEA
GO:0042475 odontogenesis of dentin-containing toothIEA
GO:0042493 response to drugIEP
GO:0042733 embryonic digit morphogenesisIEA
GO:0043065 positive regulation of apoptotic processIDA
GO:0043066 negative regulation of apoptotic processIMP
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signalingIEA
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic processIDA
GO:0043410 positive regulation of MAPK cascadeIEA
GO:0043525 positive regulation of neuron apoptotic processIDA
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transitionIMP
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic processTAS
GO:0045453 bone resorptionIEA
GO:0045603 positive regulation of endothelial cell differentiationIEA
GO:0045669 positive regulation of osteoblast differentiationIEA
GO:0045671 negative regulation of osteoclast differentiationIEA
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathwayIEA
GO:0045765 regulation of angiogenesisTAS
GO:0045892 negative regulation of transcription, DNA-templatedIMP
GO:0045893 positive regulation of transcription, DNA-templatedIMP
GO:0045893 positive regulation of transcription, DNA-templatedIDA
GO:0045944 positive regulation of transcription by RNA polymerase IIISS
GO:0045944 positive regulation of transcription by RNA polymerase IIIDA
GO:0045944 positive regulation of transcription by RNA polymerase IIIMP
GO:0045944 positive regulation of transcription by RNA polymerase IIIBA
GO:0045944 positive regulation of transcription by RNA polymerase IITAS
GO:0045976 negative regulation of mitotic cell cycle, embryonicISS
GO:0048096 chromatin-mediated maintenance of transcriptionIEA
GO:0048145 regulation of fibroblast proliferationTAS
GO:0048469 cell maturationIEA
GO:0048489 synaptic vesicle transportIEA
GO:0048538 thymus developmentIEA
GO:0048599 oocyte developmentIEA
GO:0048617 embryonic foregut morphogenesisIEA
GO:0048643 positive regulation of skeletal muscle tissue developmentIEA
GO:0048660 regulation of smooth muscle cell proliferationIMP
GO:0048715 negative regulation of oligodendrocyte differentiationIEA
GO:0050767 regulation of neurogenesisTAS
GO:0050808 synapse organizationIEA
GO:0051091 positive regulation of DNA-binding transcription factor activityIMP
GO:0051145 smooth muscle cell differentiationIEA
GO:0051149 positive regulation of muscle cell differentiationTAS
GO:0051571 positive regulation of histone H3-K4 methylationIC
GO:0051884 regulation of timing of anagenIEA
GO:0051973 positive regulation of telomerase activityIEA
GO:0060066 oviduct developmentIEA
GO:0060070 canonical Wnt signaling pathwayIDA
GO:0060070 canonical Wnt signaling pathwayIMP
GO:0060440 trachea formationIEA
GO:0060441 epithelial tube branching involved in lung morphogenesisIEA
GO:0060479 lung cell differentiationIEA
GO:0060484 lung-associated mesenchyme developmentIEA
GO:0060492 lung inductionIEA
GO:0060742 epithelial cell differentiation involved in prostate gland developmentIEA
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland developmentIEA
GO:0060789 hair follicle placode formationIEA
GO:0060828 regulation of canonical Wnt signaling pathwayTAS
GO:0060916 mesenchymal cell proliferation involved in lung developmentIEA
GO:0061154 endothelial tube morphogenesisIMP
GO:0061198 fungiform papilla formationIEA
GO:0061324 canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferationISS
GO:0061549 sympathetic ganglion developmentISS
GO:0061550 cranial ganglion developmentIEA
GO:0070602 regulation of centromeric sister chromatid cohesionIMP
GO:0071363 cellular response to growth factor stimulusIMP
GO:0071681 cellular response to indole-3-methanolIDA
GO:0072033 renal vesicle formationIEA
GO:0072053 renal inner medulla developmentIEA
GO:0072054 renal outer medulla developmentIEA
GO:0072079 nephron tubule formationIEA
GO:0072182 regulation of nephron tubule epithelial cell differentiationISS
GO:0090279 regulation of calcium ion importIDA
GO:0097091 synaptic vesicle clusteringIEA
GO:0098609 cell-cell adhesionIMP
GO:1903204 negative regulation of oxidative stress-induced neuron deathIEA
GO:1904501 positive regulation of chromatin-mediated maintenance of transcriptionIEA
GO:1904793 regulation of euchromatin bindingIEA
GO:1904798 positive regulation of core promoter bindingIDA
GO:1904837 beta-catenin-TCF complex assemblyTAS
GO:1904886 beta-catenin destruction complex disassemblyTAS
GO:1904888 cranial skeletal system developmentIEA
GO:1904948 midbrain dopaminergic neuron differentiationISS
GO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiationIC
GO:1990138 neuron projection extensionIMP
GO:1990403 embryonic brain developmentIEA
GO:1990791 dorsal root ganglion developmentIEA
GO:2000008 regulation of protein localization to cell surfaceIDA
GO:2000017 positive regulation of determination of dorsal identityIEA
GO:2000144 positive regulation of DNA-templated transcription, initiationIC
GO:2001234 negative regulation of apoptotic signaling pathwayIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0000922 spindle poleIEA
GO:0005623 cellIEA
GO:0005634 nucleusIDA
GO:0005654 nucleoplasmTAS
GO:0005667 transcription factor complexIDA
GO:0005719 nuclear euchromatinIDA
GO:0005737 cytoplasmIDA
GO:0005813 centrosomeIDA
GO:0005829 cytosolIDA
GO:0005829 cytosolTAS
GO:0005886 plasma membraneIDA
GO:0005911 cell-cell junctionIDA
GO:0005912 adherens junctionIDA
GO:0005912 adherens junctionIBA
GO:0005916 fascia adherensIEA
GO:0005923 bicellular tight junctionIEA
GO:0005925 focal adhesionHDA
GO:0005938 cell cortexIDA
GO:0016020 membraneISS
GO:0016323 basolateral plasma membraneIDA
GO:0016328 lateral plasma membraneIDA
GO:0016342 catenin complexIDA
GO:0016342 catenin complexIBA
GO:0016600 flotillin complexIEA
GO:0030018 Z discIEA
GO:0030027 lamellipodiumIEA
GO:0030054 cell junctionTAS
GO:0030054 cell junctionIDA
GO:0030877 beta-catenin destruction complexIDA
GO:0031528 microvillus membraneIEA
GO:0032991 protein-containing complexIDA
GO:0032993 protein-DNA complexIDA
GO:0034750 Scrib-APC-beta-catenin complexIEA
GO:0042734 presynaptic membraneIEA
GO:0045177 apical part of cellIEA
GO:0045202 synapseISS
GO:0045211 postsynaptic membraneIEA
GO:0048471 perinuclear region of cytoplasmIDA
GO:0070062 extracellular exosomeHDA
GO:0070369 beta-catenin-TCF7L2 complexIDA
GO:0071944 cell peripheryIDA
GO:0098685 Schaffer collateral - CA1 synapseIEA
GO:0098831 presynaptic active zone cytoplasmic componentIEA
GO:0099092 postsynaptic density, intracellular componentIEA
GO:1990907 beta-catenin-TCF complexIPI
GO:1990907 beta-catenin-TCF complexIDA
GO:1990909 Wnt signalosomeNAS

Reactome Pathway

Reactome ID Reactome Term Evidence
R-HSA-109581 ApoptosisTAS
R-HSA-111465 Apoptotic cleavage of cellular proteinsTAS
R-HSA-1266738 Developmental BiologyTAS
R-HSA-1266738 Developmental BiologyIEA
R-HSA-1500931 Cell-Cell communicationTAS
R-HSA-162582 Signal TransductionTAS
R-HSA-162582 Signal TransductionIEA
R-HSA-1643685 DiseaseTAS
R-HSA-168249 Innate Immune SystemTAS
R-HSA-168256 Immune SystemTAS
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-194138 Signaling by VEGFTAS
R-HSA-194315 Signaling by Rho GTPasesTAS
R-HSA-195253 Degradation of beta-catenin by the destruction complexTAS
R-HSA-195258 RHO GTPase EffectorsTAS
R-HSA-195721 Signaling by WNTTAS
R-HSA-195721 Signaling by WNTIEA
R-HSA-196299 Beta-catenin phosphorylation cascadeTAS
R-HSA-201681 TCF dependent signaling in response to WNTTAS
R-HSA-201681 TCF dependent signaling in response to WNTIEA
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complexIEA
R-HSA-212436 Generic Transcription PathwayTAS
R-HSA-2980736 Peptide hormone metabolismTAS
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN productionTAS
R-HSA-351906 Apoptotic cleavage of cell adhesion proteinsTAS
R-HSA-3769402 Deactivation of the beta-catenin transactivating complexTAS
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)TAS
R-HSA-3858494 Beta-catenin independent WNT signalingTAS
R-HSA-392499 Metabolism of proteinsTAS
R-HSA-400508 Incretin synthesis, secretion, and inactivationTAS
R-HSA-4086398 Ca2+ pathwayTAS
R-HSA-418990 Adherens junctions interactionsTAS
R-HSA-421270 Cell-cell junction organizationTAS
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promotersTAS
R-HSA-4420097 VEGFA-VEGFR2 PathwayTAS
R-HSA-446728 Cell junction organizationTAS
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membraneTAS
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membraneIEA
R-HSA-4791275 Signaling by WNT in cancerTAS
R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complexTAS
R-HSA-5218920 VEGFR2 mediated vascular permeabilityTAS
R-HSA-525793 MyogenesisTAS
R-HSA-525793 MyogenesisIEA
R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-cateninTAS
R-HSA-5357801 Programmed Cell DeathTAS
R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylatedTAS
R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylatedTAS
R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylatedTAS
R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylatedTAS
R-HSA-5626467 RHO GTPases activate IQGAPsTAS
R-HSA-5663202 Diseases of signal transductionTAS
R-HSA-5663205 Infectious diseaseTAS
R-HSA-73857 RNA Polymerase II TranscriptionTAS
R-HSA-74160 Gene expression (Transcription)TAS
R-HSA-75153 Apoptotic execution phaseTAS
R-HSA-8853884 Transcriptional Regulation by VENTXTAS
R-HSA-8876384 Listeria monocytogenes entry into host cellsTAS
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cellsTAS
R-HSA-8878159 Transcriptional regulation by RUNX3TAS
R-HSA-8951430 RUNX3 regulates WNT signalingTAS
R-HSA-9006934 Signaling by Receptor Tyrosine KinasesTAS

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0007 Acetylation
KW-0010 Activator
KW-0130 Cell adhesion
KW-0965 Cell junction
KW-1003 Cell membrane
KW-0966 Cell projection
KW-0160 Chromosomal rearrangement
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0225 Disease mutation
KW-0325 Glycoprotein
KW-0945 Host-virus interaction
KW-0472 Membrane
KW-0991 Mental retardation
KW-0524 Neurogenesis
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-0621 Polymorphism
KW-1185 Reference proteome
KW-0677 Repeat
KW-0702 S-nitrosylation
KW-0770 Synapse
KW-0804 Transcription
KW-0805 Transcription regulation
KW-0832 Ubl conjugation
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR013284 Beta-catenin

PROSITE

PROSITE ID PROSITE Term
PS50176 ARM_REPEAT

Pfam

Pfam ID Pfam Term
PF00514 Arm

Protein-protein interaction

Protein-miRNA interaction