| Tag | Content |
|---|---|
| Uniprot ID | P39054; Q9DBE1; |
| Entrez ID | 13430 |
| Genbank protein ID | AAA40523.1; BAB23745.1; |
| Genbank nucleotide ID | NM_001253893.1; NM_001253894.1; NM_007871.2; |
| Ensembl protein ID | ENSMUSP00000088616; ENSMUSP00000133564; |
| Ensembl nucleotide ID | ENSMUSG00000033335 |
| Gene name | Dynamin-2 |
| Gene symbol | Dnm2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 25807483 |
| Functional description | Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:18923138). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (PubMed:18425118). |
| Sequence | MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 60 SGIVTRRPLI LQLIFSKTEY AEFLHCKSKK FTDFDEVRQE IEAETDRVTG TNKGISPVPI 120 NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIKDMI LQFISRESSL ILAVTPANMD 180 LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK 240 DIEGKKDIRA ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPTLRSKL 300 QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ VDTLELSGGA 360 RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT GLFTPDLAFE AIVKKQVVKL 420 KEPCLKCVDL VIQELISTVR QCTSKLSSYP RLREETERIV TTYIREREGR TKDQILLLID 480 IEQSYINTNH EDFIGFANAQ QRSTQLNKKR AIPNQGEILV IRRGWLTINN ISLMKGGSKE 540 YWFVLTAESL SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL 600 RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE RQVETIRNLV 660 DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY SSADQSSLME ESAEQAQRRD 720 DMLRMYHALK EALNIIGDIS TSTVSTPVPP PVDDTWLQNT SGHSPTPQRR PVSSVHPPGR 780 PPAVRGPTPG PPLIPMPVGA TSSFSAPPIP SRPGPQSVFA NNDPFSAPPQ IPSRPARIPP 840 GIPPGVPSRR APAAPSRPTI IRPAEPSLLD |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003924 | GTPase activity | ISO |
| GO:0003924 | GTPase activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005525 | GTP binding | IEA |
| GO:0008017 | microtubule binding | IBA |
| GO:0017124 | SH3 domain binding | ISO |
| GO:0019901 | protein kinase binding | ISO |
| GO:0031749 | D2 dopamine receptor binding | ISO |
| GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0050699 | WW domain binding | ISO |
| GO:0050998 | nitric-oxide synthase binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000266 | mitochondrial fission | IBA |
| GO:0002031 | G protein-coupled receptor internalization | ISO |
| GO:0003281 | ventricular septum development | IMP |
| GO:0006893 | Golgi to plasma membrane transport | ISO |
| GO:0006898 | receptor-mediated endocytosis | ISS |
| GO:0006898 | receptor-mediated endocytosis | ISO |
| GO:0006909 | phagocytosis | IEA |
| GO:0007283 | spermatogenesis | IEA |
| GO:0009416 | response to light stimulus | IEA |
| GO:0010592 | positive regulation of lamellipodium assembly | ISO |
| GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane | IBA |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | ISO |
| GO:0030516 | regulation of axon extension | ISS |
| GO:0030516 | regulation of axon extension | ISO |
| GO:0031623 | receptor internalization | ISO |
| GO:0031623 | receptor internalization | IBA |
| GO:0033572 | transferrin transport | ISO |
| GO:0035020 | regulation of Rac protein signal transduction | ISO |
| GO:0035904 | aorta development | IMP |
| GO:0042220 | response to cocaine | IEA |
| GO:0044351 | macropinocytosis | ISO |
| GO:0045429 | positive regulation of nitric oxide biosynthetic process | ISO |
| GO:0045807 | positive regulation of endocytosis | ISO |
| GO:0048285 | organelle fission | IBA |
| GO:0048488 | synaptic vesicle endocytosis | IDA |
| GO:0048488 | synaptic vesicle endocytosis | IMP |
| GO:0048812 | neuron projection morphogenesis | ISS |
| GO:0048812 | neuron projection morphogenesis | ISO |
| GO:0050766 | positive regulation of phagocytosis | ISO |
| GO:0050803 | regulation of synapse structure or activity | IBA |
| GO:0060976 | coronary vasculature development | IMP |
| GO:0061025 | membrane fusion | IBA |
| GO:0071245 | cellular response to carbon monoxide | IEA |
| GO:0071481 | cellular response to X-ray | IEA |
| GO:0071732 | cellular response to nitric oxide | IEA |
| GO:0098884 | postsynaptic neurotransmitter receptor internalization | IBA |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | ISO |
| GO:1902856 | negative regulation of non-motile cilium assembly | ISO |
| GO:1903351 | cellular response to dopamine | ISO |
| GO:1903358 | regulation of Golgi organization | ISO |
| GO:1903408 | positive regulation of sodium:potassium-exchanging ATPase activity | ISO |
| GO:1903526 | negative regulation of membrane tubulation | ISO |
| GO:2000370 | positive regulation of clathrin-dependent endocytosis | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000139 | Golgi membrane | ISO |
| GO:0001891 | phagocytic cup | ISO |
| GO:0001917 | photoreceptor inner segment | IDA |
| GO:0005634 | nucleus | ISO |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IBA |
| GO:0005768 | endosome | ISO |
| GO:0005794 | Golgi apparatus | ISO |
| GO:0005802 | trans-Golgi network | ISO |
| GO:0005813 | centrosome | ISO |
| GO:0005829 | cytosol | ISO |
| GO:0005874 | microtubule | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IBA |
| GO:0005905 | clathrin-coated pit | ISS |
| GO:0005905 | clathrin-coated pit | ISO |
| GO:0014069 | postsynaptic density | IBA |
| GO:0015630 | microtubule cytoskeleton | IBA |
| GO:0016020 | membrane | IBA |
| GO:0030027 | lamellipodium | ISO |
| GO:0030054 | cell junction | ISS |
| GO:0030054 | cell junction | ISO |
| GO:0030424 | axon | IBA |
| GO:0030496 | midbody | IEA |
| GO:0030670 | phagocytic vesicle membrane | IEA |
| GO:0031410 | cytoplasmic vesicle | IBA |
| GO:0031966 | mitochondrial membrane | IBA |
| GO:0032587 | ruffle membrane | ISO |
| GO:0032991 | protein-containing complex | ISO |
| GO:0043197 | dendritic spine | IBA |
| GO:0044327 | dendritic spine head | IBA |
| GO:0045202 | synapse | IBA |
| GO:0045211 | postsynaptic membrane | ISO |
| GO:0045211 | postsynaptic membrane | IBA |
| GO:0045334 | clathrin-coated endocytic vesicle | ISO |
| GO:0048471 | perinuclear region of cytoplasm | ISO |
| GO:0098793 | presynapse | IEA |
| GO:0098844 | postsynaptic endocytic zone membrane | IBA |
| GO:0098978 | glutamatergic synapse | ISO |
| GO:0099092 | postsynaptic density, intracellular component | ISO |
| GO:0030426 | growth cone | ISS |
| GO:0030426 | growth cone | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-1280218 | Adaptive Immune System | IEA |
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-157858 | Gap junction trafficking and regulation | IEA |
| R-MMU-166016 | Toll Like Receptor 4 (TLR4) Cascade | IEA |
| R-MMU-168249 | Innate Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-168898 | Toll-like Receptor Cascades | IEA |
| R-MMU-190828 | Gap junction trafficking | IEA |
| R-MMU-190873 | Gap junction degradation | IEA |
| R-MMU-196025 | Formation of annular gap junctions | IEA |
| R-MMU-199991 | Membrane Trafficking | IEA |
| R-MMU-199992 | trans-Golgi Network Vesicle Budding | IEA |
| R-MMU-202131 | Metabolism of nitric oxide: eNOS activation and regulation | IEA |
| R-MMU-203641 | NOSTRIN mediated eNOS trafficking | IEA |
| R-MMU-2132295 | MHC class II antigen presentation | IEA |
| R-MMU-373760 | L1CAM interactions | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| R-MMU-432720 | Lysosome Vesicle Biogenesis | IEA |
| R-MMU-432722 | Golgi Associated Vesicle Biogenesis | IEA |
| R-MMU-437239 | Recycling pathway of L1 | IEA |
| R-MMU-5653656 | Vesicle-mediated transport | IEA |
| R-MMU-8856828 | Clathrin-mediated endocytosis | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0025 | Alternative splicing |
| KW-0965 | Cell junction |
| KW-0966 | Cell projection |
| KW-0168 | Coated pit |
| KW-0963 | Cytoplasm |
| KW-0968 | Cytoplasmic vesicle |
| KW-0206 | Cytoskeleton |
| KW-0903 | Direct protein sequencing |
| KW-0254 | Endocytosis |
| KW-0342 | GTP-binding |
| KW-0378 | Hydrolase |
| KW-0472 | Membrane |
| KW-0493 | Microtubule |
| KW-0505 | Motor protein |
| KW-0547 | Nucleotide-binding |
| KW-0581 | Phagocytosis |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0770 | Synapse |