| Tag | Content |
|---|---|
| Uniprot ID | P45481; E9QPH4; |
| Entrez ID | |
| Genbank protein ID | AAB28651.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Histone lysine acetyltransferase CREBBP |
| Gene symbol | Crebbp |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 16237459; 26730956; |
| Functional description | Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10207073, PubMed:11701890, PubMed:16287980, PubMed:15220471). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes (By similarity). Acts as a coactivator of ALX1 (By similarity). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (By similarity). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24737000). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (By similarity). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (By similarity). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (By similarity). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (By similarity). |
| Sequence | MAENLLDGPP NPKRAKLSSP GFSANDNTDF GSLFDLENDL PDELIPNGEL SLLNSGNLVP 60 DAASKHKQLS ELLRGGSGSS INPGIGNVSA SSPVQQGLGG QAQGQPNSTN MASLGAMGKS 120 PLNQGDSSTP NLPKQAASTS GPTPPASQAL NPQAQKQVGL VTSSPATSQT GPGICMNANF 180 NQTHPGLLNS NSGHSLMNQA QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE 240 TLTQVSPQMA GHAGLNTAQA GGMTKMGMTG TTSPFGQPFS QTGGQQMGAT GVNPQLASKQ 300 SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPTQAIA TGPTADPEKR KLIQQQLVLL 360 LHAHKCQRRE QANGEVRACS LPHCRTMKNV LNHMTHCQAG KACQVAHCAS SRQIISHWKN 420 CTRHDCPVCL PLKNASDKRN QQTILGSPAS GIQNTIGSVG AGQQNATSLS NPNPIDPSSM 480 QRAYAALGLP YMNQPQTQLQ PQVPGQQPAQ PPAHQQMRTL NALGNNPMSI PAGGITTDQQ 540 PPNLISESAL PTSLGATNPL MNDGSNSGNI GSLSTIPTAA PPSSTGVRKG WHEHVTQDLR 600 SHLVHKLVQA IFPTPDPAAL KDRRMENLVA YAKKVEGDMY ESANSRDEYY HLLAEKIYKI 660 QKELEEKRRS RLHKQGILGN QPALPASGAQ PPVIPPAQSV RPPNGPLPLP VNRMQVSQGM 720 NSFNPMSLGN VQLPQAPMGP RAASPMNHSV QMNSMASVPG MAISPSRMPQ PPNMMGTHAN 780 NIMAQAPTQN QFLPQNQFPS SSGAMSVNSV GMGQPAAQAG VSQGQVPGAA LPNPLNMLAP 840 QASQLPCPPV TQSPLHPTPP PASTAAGMPS LQHPTAPGMT PPQPAAPTQP STPVSSGQTP 900 TPTPGSVPSA AQTQSTPTVQ AAAQAQVTPQ PQTPVQPPSV ATPQSSQQQP TPVHTQPPGT 960 PLSQAAASID NRVPTPSSVT SAETSSQQPG PDVPMLEMKT EVQTDDAEPE PTESKGEPRS 1020 EMMEEDLQGS SQVKEETDTT EQKSEPMEVE EKKPEVKVEA KEEEENSSND TASQSTSPSQ 1080 PRKKIFKPEE LRQALMPTLE ALYRQDPESL PFRQPVDPQL LGIPDYFDIV KNPMDLSTIK 1140 RKLDTGQYQE PWQYVDDVWL MFNNAWLYNR KTSRVYKFCS KLAEVFEQEI DPVMQSLGYC 1200 CGRKYEFSPQ TLCCYGKQLC TIPRDAAYYS YQNRYHFCEK CFTEIQGENV TLGDDPSQPQ 1260 TTISKDQFEK KKNDTLDPEP FVDCKECGRK MHQICVLHYD IIWPSGFVCD NCLKKTGRPR 1320 KENKFSAKRL QTTRLGNHLE DRVNKFLRRQ NHPEAGEVFV RVVASSDKTV EVKPGMKSRF 1380 VDSGEMSESF PYRTKALFAF EEIDGVDVCF FGMHVQNTAL IAPHQIQGRV YISYLDSIHF 1440 FRPRCLRTAV YHEILIGYLE YVKKLGYVTG HIWACPPSEG DDYIFHCHPP DQKIPKPKRL 1500 QEWYKKMLDK AFAERIINDY KDIFKQANED RLTSAKELPY FEGDFWPNVL EESIKELEQE 1560 EEERKKEEST AASETPEGSQ GDSKNAKKKN NKKTNKNKSS ISRANKKKPS MPNVSNDLSQ 1620 KLYATMEKHK EVFFVIHLHA GPVISTQPPI VDPDPLLSCD LMDGRDAFLT LARDKHWEFS 1680 SLRRSKWSTL CMLVELHTQG QDRFVYTCNE CKHHVETRWH CTVCEDYDLC INCYNTKSHT 1740 HKMVKWGLGL DDEGSSQGEP QSKSPQESRR LSIQRCIQSL VHACQCRNAN CSLPSCQKMK 1800 RVVQHTKGCK RKTNGGCPVC KQLIALCCYH AKHCQENKCP VPFCLNIKHK LRQQQIQHRL 1860 QQAQLMRRRM ATMNTRNVPQ QSLPSPTSAP PGTPTQQPST PQTPQPPAQP QPSPVNMSPA 1920 GFPNVARTQP PTIVSAGKPT NQVPAPPPPA QPPPAAVEAA RQIEREAQQQ QHLYRANINN 1980 GMPPGRAGMG TPGSQMTPVG LNVPRPNQVS GPVMSSMPPG QWQQAPIPQQ QPMPGMPRPV 2040 MSMQAQAAVA GPRMPNVQPP RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA 2100 FIKQRTAKYV ANQPGMQPQP GLQSQPGMQP QPGMHQQPSL QNLNAMQAGV PRPGVPPPQP 2160 AMGGLNPQGQ ALNIMNPGHN PNMTNMNPQY REMVRRQLLQ HQQQQQQQQQ QQQQQQNSAS 2220 LAGGMAGHSQ FQQPQGPGGY APAMQQQRMQ QHLPIQGSSM GQMAAPMGQL GQMGQPGLGA 2280 DSTPNIQQAL QQRILQQQQM KQQIGSPGQP NPMSPQQHML SGQPQASHLP GQQIATSLSN 2340 QVRSPAPVQS PRPQSQPPHS SPSPRIQPQP SPHHVSPQTG SPHPGLAVTM ASSMDQGHLG 2400 NPEQSAMLPQ LNTPNRSALS SELSLVGDTT GDTLEKFVEG L 2441 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA |
| GO:0000987 | cis-regulatory region sequence-specific DNA binding | ISO |
| GO:0001085 | RNA polymerase II transcription factor binding | ISO |
| GO:0001085 | RNA polymerase II transcription factor binding | IPI |
| GO:0001093 | TFIIB-class transcription factor binding | IPI |
| GO:0002039 | p53 binding | ISO |
| GO:0003677 | DNA binding | IDA |
| GO:0003682 | chromatin binding | ISO |
| GO:0003682 | chromatin binding | IDA |
| GO:0003684 | damaged DNA binding | ISS |
| GO:0003684 | damaged DNA binding | ISO |
| GO:0003713 | transcription coactivator activity | ISS |
| GO:0003713 | transcription coactivator activity | ISO |
| GO:0003713 | transcription coactivator activity | TAS |
| GO:0003713 | transcription coactivator activity | IDA |
| GO:0003714 | transcription corepressor activity | ISO |
| GO:0004402 | histone acetyltransferase activity | ISS |
| GO:0004402 | histone acetyltransferase activity | ISO |
| GO:0004402 | histone acetyltransferase activity | IDA |
| GO:0004402 | histone acetyltransferase activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO:0008134 | transcription factor binding | ISS |
| GO:0008134 | transcription factor binding | ISO |
| GO:0008134 | transcription factor binding | IPI |
| GO:0008140 | cAMP response element binding protein binding | IPI |
| GO:0008270 | zinc ion binding | IMP |
| GO:0016407 | acetyltransferase activity | ISS |
| GO:0016407 | acetyltransferase activity | ISO |
| GO:0019904 | protein domain specific binding | IPI |
| GO:0033613 | activating transcription factor binding | ISO |
| GO:0042975 | peroxisome proliferator activated receptor binding | ISO |
| GO:0043426 | MRF binding | ISS |
| GO:0043426 | MRF binding | ISO |
| GO:0046332 | SMAD binding | ISO |
| GO:0061733 | peptide-lysine-N-acetyltransferase activity | ISO |
| GO:0061733 | peptide-lysine-N-acetyltransferase activity | TAS |
| GO:0097718 | disordered domain specific binding | IPI |
| GO:0003700 | DNA-binding transcription factor activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0006355 | regulation of transcription, DNA-templated | ISO |
| GO:0006355 | regulation of transcription, DNA-templated | IMP |
| GO:0006355 | regulation of transcription, DNA-templated | IDA |
| GO:0006473 | protein acetylation | ISO |
| GO:0008283 | cell population proliferation | ISO |
| GO:0010628 | positive regulation of gene expression | IGI |
| GO:0016573 | histone acetylation | ISS |
| GO:0016573 | histone acetylation | ISO |
| GO:0018076 | N-terminal peptidyl-lysine acetylation | ISS |
| GO:0018076 | N-terminal peptidyl-lysine acetylation | ISO |
| GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | ISO |
| GO:0030718 | germ-line stem cell population maintenance | IMP |
| GO:0031648 | protein destabilization | ISS |
| GO:0031648 | protein destabilization | ISO |
| GO:0032793 | positive regulation of CREB transcription factor activity | IDA |
| GO:0034644 | cellular response to UV | ISS |
| GO:0034644 | cellular response to UV | ISO |
| GO:0035729 | cellular response to hepatocyte growth factor stimulus | IDA |
| GO:0045358 | negative regulation of interferon-beta biosynthetic process | IMP |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISS |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IGI |
| GO:0048511 | rhythmic process | IEA |
| GO:0048525 | negative regulation of viral process | IMP |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | TAS |
| GO:0060325 | face morphogenesis | IMP |
| GO:0060355 | positive regulation of cell adhesion molecule production | ISO |
| GO:0098586 | cellular response to virus | IMP |
| GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | ISO |
| GO:1901224 | positive regulation of NIK/NF-kappaB signaling | ISO |
| GO:1990258 | histone glutamine methylation | ISS |
| GO:1990258 | histone glutamine methylation | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000123 | histone acetyltransferase complex | IDA |
| GO:0000790 | nuclear chromatin | ISO |
| GO:0000790 | nuclear chromatin | IDA |
| GO:0000940 | condensed chromosome outer kinetochore | IDA |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005667 | transcription factor complex | ISO |
| GO:0005667 | transcription factor complex | IDA |
| GO:0005737 | cytoplasm | ISO |
| GO:0016604 | nuclear body | ISO |
| GO:0016605 | PML body | ISO |
| GO:0032991 | protein-containing complex | ISO |
| GO:0032991 | protein-containing complex | IMP |
| GO:0090575 | RNA polymerase II transcription factor complex | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0007 | Acetylation |
| KW-0010 | Activator |
| KW-0012 | Acyltransferase |
| KW-0090 | Biological rhythms |
| KW-0103 | Bromodomain |
| KW-0963 | Cytoplasm |
| KW-1017 | Isopeptide bond |
| KW-0479 | Metal-binding |
| KW-0488 | Methylation |
| KW-0539 | Nucleus |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0804 | Transcription |
| KW-0805 | Transcription regulation |
| KW-0808 | Transferase |
| KW-0832 | Ubl conjugation |
| KW-0862 | Zinc |
| KW-0863 | Zinc-finger |
| InterPro ID | InterPro Term |
|---|---|
| IPR001487 | Bromodomain |
| IPR036427 | Bromodomain-like_sf |
| IPR018359 | Bromodomain_CS |
| IPR031162 | CBP_P300_HAT |
| IPR013178 | Histone_AcTrfase_Rtt109/CBP |
| IPR003101 | KIX_dom |
| IPR036529 | KIX_dom_sf |
| IPR009110 | Nuc_rcpt_coact |
| IPR014744 | Nuc_rcpt_coact_CREBbp |
| IPR037073 | Nuc_rcpt_coact_CREBbp_sf |
| IPR010303 | RING_CBP-p300 |
| IPR038547 | RING_CBP-p300_sf |
| IPR035898 | TAZ_dom_sf |
| IPR013083 | Znf_RING/FYVE/PHD |
| IPR000197 | Znf_TAZ |
| IPR000433 | Znf_ZZ |
| IPR043145 | Znf_ZZ_sf |