| Tag | Content |
|---|---|
| Uniprot ID | P47931; A6H6P0; |
| Entrez ID | 14313 |
| Genbank protein ID | AAI45946.1; CAA82648.1; AAI44927.1; CAA58291.1; |
| Genbank nucleotide ID | NM_001301375.1; NM_001301373.1; NM_008046.3; |
| Ensembl protein ID | ENSMUSP00000156375; ENSMUSP00000022287; |
| Ensembl nucleotide ID | ENSMUSG00000021765 |
| Gene name | Follistatin |
| Gene symbol | Fst |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 7885475 |
| Functional description | Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). |
| Sequence | MVCARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL SKEECCSTGR 60 LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC GPGKKCRMNK KNKPRCVCAP 120 DCSNITWKGP VCGLDGKTYR NECALLKARC KEQPELEVQY QGKCKKTCRD VFCPGSSTCV 180 VDQTNNAYCV TCNRICPEPS SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI 240 KAKSCEDIQC GGGKKCLWDS KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA 300 ACSSGVLLEV KHSGSCNSIS EETEEEEEEE DQDYSFPISS ILEW 344 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0038102 | activin receptor antagonist activity | ISO |
| GO:0043395 | heparan sulfate proteoglycan binding | ISO |
| GO:0048185 | activin binding | ISO |
| GO:0048185 | activin binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0001501 | skeletal system development | IGI |
| GO:0002244 | hematopoietic progenitor cell differentiation | ISO |
| GO:0007275 | multicellular organism development | IBA |
| GO:0007276 | gamete generation | IGI |
| GO:0007389 | pattern specification process | IMP |
| GO:0008585 | female gonad development | IMP |
| GO:0030154 | cell differentiation | IBA |
| GO:0030509 | BMP signaling pathway | IGI |
| GO:0030510 | regulation of BMP signaling pathway | IBA |
| GO:0031069 | hair follicle morphogenesis | IMP |
| GO:0032926 | negative regulation of activin receptor signaling pathway | ISO |
| GO:0032926 | negative regulation of activin receptor signaling pathway | IBA |
| GO:0042475 | odontogenesis of dentin-containing tooth | IMP |
| GO:0043616 | keratinocyte proliferation | IMP |
| GO:0045596 | negative regulation of cell differentiation | IGI |
| GO:0045596 | negative regulation of cell differentiation | IMP |
| GO:0051798 | positive regulation of hair follicle development | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | IBA |
| GO:0005615 | extracellular space | HDA |
| GO:0005634 | nucleus | IDA |
| GO:0005737 | cytoplasm | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1502540 | Signaling by Activin | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-2473224 | Antagonism of Activin by Follistatin | IEA |
| R-MMU-9006936 | Signaling by TGF-beta family members | IEA |