| Tag | Content |
|---|---|
| Uniprot ID | P48725; A0JBT0; A0JBT1; |
| Entrez ID | 18541 |
| Genbank protein ID | AAA17886.1; BAF36559.1; BAF36560.1; |
| Genbank nucleotide ID | NM_001282992.1; NM_008787.3; |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Pericentrin |
| Gene symbol | Pcnt |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 27933520 |
| Functional description | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. |
| Sequence | MEDEQEQRRR KVEAGRAKLA NFRQRKTKGD CPNSKKKTAK RKGSAVHASV QEEGSVATPN 60 SELPQGGAVF ESPSCSNTLE GTRGASAAQE QEDCELDVTD LQGQQQTQPP PPQTAHSLEL 120 EALRLSLNNM HTAQLELTQA NLQKEKETAL TELREMLNGR RAQELALLQS RQQCELELLR 180 EQHAREKEEM ALRSGQEAAE LKEKLRSEME KNAQTIETLK QDWESERELC LENLRQELSL 240 KHQSEMEGLQ SQFQKELSEQ KVELEKIFQA KHEAEVSLKN LEAQHQAAIK KLQEDLQSEH 300 CQYLQDLEQK FREKEKAKEL ELETLQASYE DLKAQSQEEI RLLWSQLESM KTNREELNGS 360 WDPVLAQASH LEELEHLRSG FAQQQQQERA QHESELEHLR VYFEKKLKDA EKTYQEDLTV 420 FQQRLQEARE DSLESTEISS SCVLPEETSG REGKEPPDPL DLQLGQPKVQ ESLVEDCQVK 480 LSKAEEKIQQ MKEEFQKKEA EWELSREELK REAEERLASM FLELREKAES EKLSIISRFE 540 HRESSMRHLQ DQQAAQILDL ERSLMEQQGH LRQLEQELTR DDLLPCSQCG QEPAMAQEEK 600 NGALLREKED CALQLLMAQN RFLEERKEIM EKFAKEQDAF LRDAQEKHNH ELQLLQQGHQ 660 QQLLALRMEL ETKHRSELTE QLASSESRRQ ALLETHVAEL QVKHNAEISA LEKRHLSNLD 720 ELESCYVADV QTIRDEHQQA LELLRAELEE QLQKKESCHR EMLTQELENL KRQHAEELQS 780 VRDSLRMEMS AQHIENGKGP AADLQGAHQQ DPAMALHNEG HLLVEDGDAV LRSVDAEGLL 840 HQAGPQELGD AHTVEMQKSQ AELAKPQELQ ASQDQVAQVR DKVFLLNREL EECRAELEQL 900 QQRRERENQE GTTLICMLRA DLELAQGEGK ALRDALRRLL DLFGDTLKAA VTLKSRISER 960 AGLLLDHEDA ADTSDARLAA AALGDMWSDE GLLEIDRTLP EGAETSSVCE ISSHVCESFF 1020 ISPENTLDCE QPIRRVYQSL STAVEGLLEM ALDSSKQLEE ARQLHRCVER EFRHRNEEMA 1080 QAMQKQQELL ERLREESAAK DRLALELHTA KGLLEGFKVE KVDLQEALGK KEESEQQLIL 1140 ELEDLRKQLQ QAARELLTLK EEKSVLWNQK ETLTNEAKER EAALQEEVES LTRVQWESRK 1200 QSEKDRATLL SQMRVLESEL EDQLVQHRGC AQLAEEVATL KQQLAALDKH LRSQRQFMDD 1260 QAAEREHERE EFQQEIQRLE GQLRQAARPR PPGPRDSQCV QLDEEVELLQ EKLREKLDGF 1320 NELVIKKDFA DQQLLIQEEE IKRLEETNAS IQRQMVQLQE ELEKQKKSME ELKEKEILKQ 1380 ENMGDLLLTT VSRSGLDEAG CPMLPQGSSS RGPEAQPDVT ERALLQHENE VVHRRNSEID 1440 ELKSLIENLQ ENQRQLQKDK AEEIEQLHEV IEKLQSELSL MGPKVHEVSD PQAGSLHSEL 1500 ACLRGEGLGG QALRSELQAA QAAKEVFGQL LANQAHGHSQ ALEALQQRLQ DAEEVAARHL 1560 AELEHCVALR EAEVEAMASQ IQEFAATLKA KEAIIEQRDL EIDAVNKWKV SHSLELEAIL 1620 LALAHFRHAL EQQTCATPDE PPELRQLRVQ CARLSHQLQV LYRPFLKCRM QLDQHQPHVA 1680 SIGCANPCAD DELEQEGVSN RLALAPHSLA AQAKEELEDC PLGKANLMAQ VRQLQEELDH 1740 RVHSVASRDT NSETCKLQQP NLSENGPRNH CCNGEESKPS PPDDVLNIAK TTWDVIDIIK 1800 NQDLLVQVEM PDFPTQEKLT SQGGPFSSQA SGHSGSLLPE EAAEPQQDPV RALDLSSWSS 1860 PEVVRKDPSL EPQHSLPLTP GVGTVSLHSV DISPDWTDPL LQADVSGLLC YPGKSASGQA 1920 PLWAVAPSAG KHHAERTATE KDVEDFIVTS FDSQELLTSP SHELARRSDG SRKSDGPDIA 1980 MMLTLGSEGS ETPTTDLVAA AAAAVPFSRR FVQSPGAMKE KEIHAKQMKA LLQMVFDESH 2040 QILALSESQD PSSALNKGEP RDPLDGFPRD SQALSEVTTD KGEKESLETH LTWSEELLRA 2100 IQEVFAREQE KAELQPRPYG SNLGDYNSLV QRLEKVIQEQ GDPQKVQDHL CLSDRSSLLA 2160 EIQALRAQLR MTHLQNQEKL QQLCAALTST EARGSQREHQ LRRQVELLAY KVEQEKCIAN 2220 ELQKTLSKEQ ETASDVRKRL VVEQNAVQDL KSELHACKQE NTSLLESLDK VQQEVLRLRA 2280 VLDGKEKELK VVLEELESER GKGQALQAQQ EEQQLRYLQR EGQSSRALEE LKLSLEKQLA 2340 QNNQLCVALK HERAAKDNLQ KELQIEASRC EALLAQEKGQ LSELQKSLEA ERSRSLELSE 2400 ALQHERLLTE QLSRNSQEAC ARQETQVQHA LLRKLKAEKT RALELEAMLE KVQKQAAHTQ 2460 QQLEAQAQER CVELRREKER ELEIQRQRDE HKIEQLQRLV RELRWKEEVS GGNGPCRGSP 2520 GRGSLERDQF QEQQQELEKI RQQLLCAAGL LTSFTNHTVD RTIKDWTSSN EKAVSSLMRT 2580 LEELKSELSM PTSFQKKMTA ELQVQLMNEL LSDNDALTKA VGMATREKAE LCRTVSRLEK 2640 TLKHHTQKGC VLNRQSKSSL KQDGTDLQSS LRHSDPEWHS QTTSGDTNTC NIKMEKLYLH 2700 YLRAESFRKA LIYQKKYLLL LIGGFQDSEQ ETLSMIAHLG VFPSKADKKI TMSRPFTKFR 2760 TAVRVVIAVL RLRFLVKKWQ EVDRKGALVH PKSTRHGHRT SQRQRSPSGP RASLPTRDTS 2820 SGPTKASRHS PRSAAAGSPG KERSTSTPSS RLERSLTASQ DPEHSLTEYI HHLEMIQQRL 2880 GGLPPDSTQK SCHQKIKQ 2898 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0005516 | calmodulin binding | IEA |
| GO:0060090 | molecular adaptor activity | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000226 | microtubule cytoskeleton organization | ISS |
| GO:0001701 | in utero embryonic development | IMP |
| GO:0001764 | neuron migration | IMP |
| GO:0001822 | kidney development | IMP |
| GO:0001944 | vasculature development | IMP |
| GO:0007051 | spindle organization | IDA |
| GO:0007052 | mitotic spindle organization | IMP |
| GO:0007165 | signal transduction | IEA |
| GO:0021696 | cerebellar cortex morphogenesis | IMP |
| GO:0021772 | olfactory bulb development | IMP |
| GO:0035050 | embryonic heart tube development | IMP |
| GO:0035108 | limb morphogenesis | IMP |
| GO:0035264 | multicellular organism growth | IMP |
| GO:0043010 | camera-type eye development | IMP |
| GO:0043066 | negative regulation of apoptotic process | IMP |
| GO:0048854 | brain morphogenesis | IMP |
| GO:0060271 | cilium assembly | ISO |
| GO:0060322 | head development | IMP |
| GO:0061351 | neural precursor cell proliferation | IMP |
| GO:0090316 | positive regulation of intracellular protein transport | ISS |
| GO:1990403 | embryonic brain development | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000242 | pericentriolar material | IDA |
| GO:0005813 | centrosome | ISS |
| GO:0005813 | centrosome | IDA |
| GO:0005813 | centrosome | ISO |
| GO:0005814 | centriole | IDA |
| GO:0005814 | centriole | ISO |
| GO:0005815 | microtubule organizing center | IDA |
| GO:0005874 | microtubule | IEA |
| GO:0031514 | motile cilium | IDA |
| GO:0034451 | centriolar satellite | ISS |
| GO:0036064 | ciliary basal body | IDA |
| GO:0045171 | intercellular bridge | IDA |
| GO:0005801 | cis-Golgi network | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1632852 | Macroautophagy | IEA |
| R-MMU-1640170 | Cell Cycle | IEA |
| R-MMU-1852241 | Organelle biogenesis and maintenance | IEA |
| R-MMU-2565942 | Regulation of PLK1 Activity at G2/M Transition | IEA |
| R-MMU-380259 | Loss of Nlp from mitotic centrosomes | IEA |
| R-MMU-380270 | Recruitment of mitotic centrosome proteins and complexes | IEA |
| R-MMU-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | IEA |
| R-MMU-380287 | Centrosome maturation | IEA |
| R-MMU-380320 | Recruitment of NuMA to mitotic centrosomes | IEA |
| R-MMU-453274 | Mitotic G2-G2/M phases | IEA |
| R-MMU-5617833 | Cilium Assembly | IEA |
| R-MMU-5620912 | Anchoring of the basal body to the plasma membrane | IEA |
| R-MMU-68877 | Mitotic Prometaphase | IEA |
| R-MMU-68886 | M Phase | IEA |
| R-MMU-69275 | G2/M Transition | IEA |
| R-MMU-69278 | Cell Cycle, Mitotic | IEA |
| R-MMU-8854518 | AURKA Activation by TPX2 | IEA |
| R-MMU-9612973 | Autophagy | IEA |
| R-MMU-9646399 | Aggrephagy | IEA |
| R-MMU-9663891 | Selective autophagy | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF10495 | PACT_coil_coil |