CleftGeneDB-Search

Gene: GSK3B

Basic information

Tag	Content
Uniprot ID	P49841; D3DN89; Q9BWH3; Q9UL47;
Entrez ID	2932
Genbank protein ID	EAW79533.1; AAD48517.1; EAW79536.1; AAH12760.1; AAA66475.1; AAH00251.1; AAC69340.1;
Genbank nucleotide ID	NM_001146156.1; NM_002093.3;
Ensembl protein ID	ENSP00000264235; ENSP00000324806;
Ensembl nucleotide ID	ENSG00000082701
Gene name	Glycogen synthase kinase-3 beta
Gene symbol	GSK3B
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and ARNTL/BMLA1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110).
Sequence	MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 60 VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 120 EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 180 DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 240 WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300 WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF 360 NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST 420

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1GNG
1H8F
1I09
1J1B
1J1C
1O6K
1O6L
1O9U
1PYX
1Q3D
1Q3W
1Q41
1Q4L
1Q5K
1R0E
1UV5
2JDO
2JDR
2JLD
2O5K
2OW3
2UW9
2X39
2XH5
3CQU
3CQW
3DU8
3E87
3E88
3E8D
3F7Z
3F88
3GB2
3I4B
3L1S
3M1S
3MV5
3OW4
3PUP
3Q3B
3QKK
3SAY
3SD0
3ZDI
3ZRK
3ZRL
3ZRM
4ACC
4ACD
4ACG
4ACH
4AFJ
4B7T
4DIT
4EKK
4IQ6
4J1R
4J71
4NM0
4NM3
4NM5
4NM7
4PTC
4PTE
4PTG
5F94
5F95
5HLN
5HLP
5K5N
5KPK
5KPL
5KPM
5OY4
5T31
6B8J
6BUU
6GJO
6GN1
6H0U
6HK3
6HK4
6HK7
6NPZ
6V6L
1J1B
1Q5K
1UV5
2JDO
4ACC
4AFJ
4NM3
4NM5
5KPK

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	GSK3B	478575	E2RB53			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	GSK3B1	102176363	A0A097P8R4			Capra hircus	Prediction	More>>
1:1 ortholog	GSK3B	2932	P49841			Homo sapiens	Prediction	More>>
1:1 ortholog	Gsk3b	56637	Q9WV60	CPO	E12.5, E13.5, E14.5, P6	Mus musculus	Publication	More>>
1:1 ortholog	GSK3B	100616510	K7CFX8			Pan troglodytes	Prediction	More>>
1:1 ortholog	GSK3B		I6ZJZ7			Sus scrofa	Prediction	More>>
1:1 ortholog	GSK3B	100348842	A0A5F9CM08			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Gsk3b	84027	A0A0G2KB98			Rattus norvegicus	Prediction	More>>
1:1 ortholog	gsk3ba	30654	Q9YH60			Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
NCI-TCGA novel	p.Thr8Ser	missense variant	-	NC_000003.12:g.120093413T>A	NCI-TCGA
rs1436410958	p.Cys14Ter	stop gained	-	NC_000003.12:g.120093393G>T	gnomAD
rs373508918	p.Lys15Glu	missense variant	-	NC_000003.12:g.120093392T>C	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gln19Arg	missense variant	-	NC_000003.12:g.120093379T>C	NCI-TCGA
rs750102236	p.Ala22Pro	missense variant	-	NC_000003.12:g.120093371C>G	ExAC,gnomAD
NCI-TCGA novel	p.Ala22Ser	missense variant	-	NC_000003.12:g.120093371C>A	NCI-TCGA
rs774835112	p.Phe23Cys	missense variant	-	NC_000003.12:g.120093367A>C	ExAC,gnomAD
rs769312285	p.Phe23Leu	missense variant	-	NC_000003.12:g.120093366A>T	ExAC,gnomAD
rs1368413587	p.Gly24Val	missense variant	-	NC_000003.12:g.120093364C>A	gnomAD
NCI-TCGA novel	p.Ser25Asn	missense variant	-	NC_000003.12:g.120093361C>T	NCI-TCGA
rs1309654926	p.Met26Val	missense variant	-	NC_000003.12:g.120093359T>C	gnomAD
rs1309654926	p.Met26Leu	missense variant	-	NC_000003.12:g.120093359T>A	gnomAD
rs763333358	p.Met26Ile	missense variant	-	NC_000003.12:g.120093357C>T	ExAC,gnomAD
rs1162665263	p.Ser29Arg	missense variant	-	NC_000003.12:g.120093348G>C	gnomAD
rs769708545	p.Ser29Asn	missense variant	-	NC_000003.12:g.120093349C>T	ExAC,gnomAD
rs769708545	p.Ser29Thr	missense variant	-	NC_000003.12:g.120093349C>G	ExAC,gnomAD
rs1269622391	p.Gly34Ser	missense variant	-	NC_000003.12:g.120002228C>T	gnomAD
rs1269622391	p.Gly34Ser	missense variant	-	NC_000003.12:g.120002228C>T	NCI-TCGA Cosmic
rs759572039	p.Thr38Ile	missense variant	-	NC_000003.12:g.120002215G>A	ExAC,gnomAD
rs776666984	p.Thr39Ala	missense variant	-	NC_000003.12:g.120002213T>C	ExAC,gnomAD
rs771162975	p.Thr43Ala	missense variant	-	NC_000003.12:g.120002201T>C	ExAC,gnomAD
rs1422948653	p.Thr43Ile	missense variant	-	NC_000003.12:g.120002200G>A	TOPMed
rs200600198	p.Gly47Val	missense variant	-	NC_000003.12:g.120002188C>A	gnomAD
rs768381879	p.Pro48Thr	missense variant	-	NC_000003.12:g.120002186G>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Asp49Asn	missense variant	-	NC_000003.12:g.120002183C>T	NCI-TCGA
rs999399448	p.Gln52Lys	missense variant	-	NC_000003.12:g.120002174G>T	TOPMed,gnomAD
NCI-TCGA novel	p.Glu53Ter	stop gained	-	NC_000003.12:g.120002171C>A	NCI-TCGA
COSM1036838	p.Glu53Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.120002171C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Thr59Ile	missense variant	-	NC_000003.12:g.120002152G>A	NCI-TCGA
rs1043846922	p.Lys60Glu	missense variant	-	NC_000003.12:g.120002150T>C	gnomAD
rs1451473946	p.Lys60Asn	missense variant	-	NC_000003.12:g.120002148T>G	TOPMed
rs779897228	p.Val61Leu	missense variant	-	NC_000003.12:g.120002147C>G	ExAC,gnomAD
rs1319842683	p.Val61Ala	missense variant	-	NC_000003.12:g.120002146A>G	TOPMed
rs1178691948	p.Ile62Val	missense variant	-	NC_000003.12:g.120002144T>C	gnomAD
COSM4112592	p.Gly68Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.120002125C>A	NCI-TCGA Cosmic
rs184532476	p.Val70Ile	missense variant	-	NC_000003.12:g.120002120C>T	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Lys74Thr	missense variant	-	NC_000003.12:g.120002107T>G	NCI-TCGA
rs202134968	p.Ser78Leu	missense variant	-	NC_000003.12:g.120002095G>A	ExAC,TOPMed,gnomAD
COSM1036836	p.Glu80Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000003.12:g.120002090C>A	NCI-TCGA Cosmic
COSM294429	p.Ala83Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.120002081C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Val87Ile	missense variant	-	NC_000003.12:g.120002069C>T	NCI-TCGA
COSM4112590	p.Arg92Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.120002053C>A	NCI-TCGA Cosmic
rs1163587458	p.Arg96Ter	stop gained	-	NC_000003.12:g.119947348G>A	gnomAD
COSM1036834	p.Arg96Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119947347C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Glu97Lys	missense variant	-	NC_000003.12:g.119947345C>T	NCI-TCGA
NCI-TCGA novel	p.Arg102Ile	missense variant	-	NC_000003.12:g.119947329C>A	NCI-TCGA
COSM3585811	p.Arg102Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119947329C>T	NCI-TCGA Cosmic
rs1189138605	p.Asp105Gly	missense variant	-	NC_000003.12:g.119947320T>C	gnomAD
rs773253962	p.Cys107Tyr	missense variant	-	NC_000003.12:g.119947314C>T	ExAC,gnomAD
rs767657425	p.Asn108His	missense variant	-	NC_000003.12:g.119947312T>G	ExAC,TOPMed,gnomAD
rs762056483	p.Arg111Gln	missense variant	-	NC_000003.12:g.119947302C>T	ExAC,TOPMed,gnomAD
rs762056483	p.Arg111Gln	missense variant	-	NC_000003.12:g.119947302C>T	NCI-TCGA,NCI-TCGA Cosmic
rs762056483	p.Arg111Leu	missense variant	-	NC_000003.12:g.119947302C>A	ExAC,TOPMed,gnomAD
COSM1036832	p.Arg111Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000003.12:g.119947303G>A	NCI-TCGA Cosmic
rs769576748	p.Arg113His	missense variant	-	NC_000003.12:g.119947296C>T	ExAC,gnomAD
rs775155403	p.Arg113Cys	missense variant	-	NC_000003.12:g.119947297G>A	ExAC,gnomAD
COSM1036828	p.Phe115Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119947289G>T	NCI-TCGA Cosmic
rs776780339	p.Ser119Gly	missense variant	-	NC_000003.12:g.119947279T>C	ExAC,gnomAD
COSM116745	p.Glu121Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119947271C>G	NCI-TCGA Cosmic
rs1246291930	p.Lys123Glu	missense variant	-	NC_000003.12:g.119923483T>C	gnomAD
rs541918115	p.Asp124Glu	missense variant	-	NC_000003.12:g.119923478A>C	1000Genomes,ExAC,gnomAD
rs1278284853	p.Val126Ile	missense variant	-	NC_000003.12:g.119923474C>T	gnomAD
rs1347660914	p.Tyr127Cys	missense variant	-	NC_000003.12:g.119923470T>C	gnomAD
rs1347660914	p.Tyr127Cys	missense variant	-	NC_000003.12:g.119923470T>C	NCI-TCGA Cosmic
rs1275927228	p.Leu132Met	missense variant	-	NC_000003.12:g.119923456G>T	TOPMed,gnomAD
rs1228373745	p.Asp133Asn	missense variant	-	NC_000003.12:g.119923453C>T	gnomAD
rs747598536	p.Tyr134Cys	missense variant	-	NC_000003.12:g.119923449T>C	ExAC,TOPMed,gnomAD
rs972600014	p.Val135Ile	missense variant	-	NC_000003.12:g.119923447C>T	TOPMed,gnomAD
rs1345405296	p.Pro136Gln	missense variant	-	NC_000003.12:g.119923443G>T	gnomAD
rs1345405296	p.Pro136Leu	missense variant	-	NC_000003.12:g.119923443G>A	gnomAD
rs374053953	p.Tyr140Cys	missense variant	-	NC_000003.12:g.119923431T>C	ESP,ExAC,gnomAD
rs200380044	p.Ala143Ser	missense variant	-	NC_000003.12:g.119923423C>A	ExAC,gnomAD
rs1388335197	p.Tyr146Cys	missense variant	-	NC_000003.12:g.119923413T>C	gnomAD
rs576401632	p.Ser147Asn	missense variant	-	NC_000003.12:g.119923410C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1450227743	p.Arg148Ter	stop gained	-	NC_000003.12:g.119923408G>A	gnomAD
rs757429682	p.Arg148Gln	missense variant	-	NC_000003.12:g.119923407C>T	ExAC,gnomAD
NCI-TCGA novel	p.Arg148Gly	missense variant	-	NC_000003.12:g.119923408G>C	NCI-TCGA
rs751566414	p.Ala149Gly	missense variant	-	NC_000003.12:g.119923404G>C	ExAC,TOPMed,gnomAD
rs764422326	p.Thr152Ala	missense variant	-	NC_000003.12:g.119923396T>C	ExAC,gnomAD
rs72546695	p.Thr152Met	missense variant	-	NC_000003.12:g.119923395G>A	ESP,ExAC,TOPMed,gnomAD
rs766207294	p.Leu153Pro	missense variant	-	NC_000003.12:g.119923392A>G	ExAC,gnomAD
COSM1418068	p.Ile156Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119923382A>C	NCI-TCGA Cosmic
rs758696011	p.Tyr161Cys	missense variant	-	NC_000003.12:g.119916170T>C	ExAC,TOPMed,gnomAD
rs199990599	p.Met162Val	missense variant	-	NC_000003.12:g.119916168T>C	TOPMed
rs1462455112	p.Met162Ile	missense variant	-	NC_000003.12:g.119916166C>T	gnomAD
NCI-TCGA novel	p.Tyr163Asp	missense variant	-	NC_000003.12:g.119916165A>C	NCI-TCGA
rs148468264	p.Phe166Leu	missense variant	-	NC_000003.12:g.119916154G>T	ESP,ExAC,TOPMed,gnomAD
rs201787969	p.Arg167Ter	stop gained	-	NC_000003.12:g.119916153G>A	ExAC,gnomAD
rs756003147	p.Arg167Gln	missense variant	-	NC_000003.12:g.119916152C>T	ExAC,gnomAD
rs201787969	p.Arg167Ter	stop gained	-	NC_000003.12:g.119916153G>A	NCI-TCGA,NCI-TCGA Cosmic
rs756003147	p.Arg167Gln	missense variant	-	NC_000003.12:g.119916152C>T	NCI-TCGA,NCI-TCGA Cosmic
rs200780530	p.Ala170Thr	missense variant	-	NC_000003.12:g.119916144C>T	TOPMed
rs1391379309	p.Tyr171Phe	missense variant	-	NC_000003.12:g.119916140T>A	TOPMed
NCI-TCGA novel	p.Ile172Thr	missense variant	-	NC_000003.12:g.119916137A>G	NCI-TCGA
COSM1036822	p.His179Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119916117G>T	NCI-TCGA Cosmic
COSM1418066	p.Arg180Trp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119916114G>A	NCI-TCGA Cosmic
COSM244836	p.Arg180Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119916113C>T	NCI-TCGA Cosmic
rs1334056340	p.Pro184Leu	missense variant	-	NC_000003.12:g.119916101G>A	gnomAD
rs1334056340	p.Pro184Leu	missense variant	-	NC_000003.12:g.119916101G>A	NCI-TCGA Cosmic
rs200768845	p.Val195Ile	missense variant	-	NC_000003.12:g.119916069C>T	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Lys197AsnPheSerTerUnkUnk	frameshift	-	NC_000003.12:g.119916061T>-	NCI-TCGA
NCI-TCGA novel	p.Cys199Ter	stop gained	-	NC_000003.12:g.119916055A>T	NCI-TCGA
rs1275534046	p.Gln206Arg	missense variant	-	NC_000003.12:g.119912802T>C	TOPMed
rs1220893466	p.Val208Leu	missense variant	-	NC_000003.12:g.119912797C>G	gnomAD
rs1371764974	p.Arg209Gln	missense variant	-	NC_000003.12:g.119912793C>T	gnomAD
NCI-TCGA novel	p.Glu211Ter	stop gained	-	NC_000003.12:g.119912788C>A	NCI-TCGA
NCI-TCGA novel	p.Glu211AspPheSerTerUnkUnk	frameshift	-	NC_000003.12:g.119912786T>-	NCI-TCGA
rs1433092365	p.Pro212Arg	missense variant	-	NC_000003.12:g.119912784G>C	gnomAD
rs759068324	p.Pro212Ser	missense variant	-	NC_000003.12:g.119912785G>A	ExAC,gnomAD
rs1260622686	p.Asn213Ser	missense variant	-	NC_000003.12:g.119912781T>C	gnomAD
rs1308939025	p.Ser215Pro	missense variant	-	NC_000003.12:g.119912776A>G	TOPMed
COSM4112584	p.Ser215Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119912775G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Tyr216Cys	missense variant	-	NC_000003.12:g.119912772T>C	NCI-TCGA
rs1289744832	p.Arg220Trp	missense variant	-	NC_000003.12:g.119912761G>A	gnomAD
rs747385360	p.Pro225Leu	missense variant	-	NC_000003.12:g.119912745G>A	ExAC,gnomAD
NCI-TCGA novel	p.Ile228Asn	missense variant	-	NC_000003.12:g.119912736A>T	NCI-TCGA
COSM4933052	p.Phe229Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119912732A>C	NCI-TCGA Cosmic
rs927477936	p.Thr235Asn	missense variant	-	NC_000003.12:g.119912715G>T	TOPMed
rs1263369470	p.Ser237Gly	missense variant	-	NC_000003.12:g.119912710T>C	gnomAD
COSM269287	p.Ile238Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119912706A>G	NCI-TCGA Cosmic
rs200882593	p.Val240Leu	missense variant	-	NC_000003.12:g.119905850C>A	ExAC,TOPMed,gnomAD
rs200882593	p.Val240Ile	missense variant	-	NC_000003.12:g.119905850C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gly244Asp	missense variant	-	NC_000003.12:g.119905837C>T	NCI-TCGA
rs749385392	p.Leu247Phe	missense variant	-	NC_000003.12:g.119905827C>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu249Lys	missense variant	-	NC_000003.12:g.119905823C>T	NCI-TCGA
rs770039569	p.Ile256Val	missense variant	-	NC_000003.12:g.119905802T>C	ExAC,gnomAD
rs746833524	p.Gly262Asp	missense variant	-	NC_000003.12:g.119905783C>T	ExAC,gnomAD
NCI-TCGA novel	p.Gly262Ser	missense variant	-	NC_000003.12:g.119905784C>T	NCI-TCGA
NCI-TCGA novel	p.Glu268Ter	stop gained	-	NC_000003.12:g.119905766C>A	NCI-TCGA
rs762995497	p.Val272Ile	missense variant	-	NC_000003.12:g.119876508C>T	ExAC
rs775594725	p.Val272Ala	missense variant	-	NC_000003.12:g.119876507A>G	ExAC,gnomAD
rs770038325	p.Arg278Lys	missense variant	-	NC_000003.12:g.119876489C>T	ExAC,gnomAD
rs200373768	p.Arg278Gly	missense variant	-	NC_000003.12:g.119876490T>C	1000Genomes
rs568223760	p.Glu279Lys	missense variant	-	NC_000003.12:g.119876487C>T	1000Genomes,ExAC,gnomAD
rs773000672	p.Arg282Thr	missense variant	-	NC_000003.12:g.119876477C>G	ExAC,gnomAD
NCI-TCGA novel	p.Glu283Ter	stop gained	-	NC_000003.12:g.119876475C>A	NCI-TCGA
rs771909190	p.Pro286Ser	missense variant	-	NC_000003.12:g.119876466G>A	ExAC,gnomAD
NCI-TCGA novel	p.Pro286Arg	missense variant	-	NC_000003.12:g.119876465G>C	NCI-TCGA
NCI-TCGA novel	p.Glu290Ala	missense variant	-	NC_000003.12:g.119876453T>G	NCI-TCGA
rs549729441	p.Gln295His	missense variant	-	NC_000003.12:g.119876437T>G	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Gln295Glu	missense variant	-	NC_000003.12:g.119876439G>C	NCI-TCGA
NCI-TCGA novel	p.Pro300His	missense variant	-	NC_000003.12:g.119876423G>T	NCI-TCGA
COSM281576	p.Trp301Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119876421A>G	NCI-TCGA Cosmic
COSM1036816	p.Trp301Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000003.12:g.119876419C>T	NCI-TCGA Cosmic
rs1441114375	p.Thr302Ile	missense variant	-	NC_000003.12:g.119876417G>A	gnomAD
rs140668532	p.Val304Phe	missense variant	-	NC_000003.12:g.119863605C>A	ESP,TOPMed,gnomAD
rs768552900	p.Arg306Ter	stop gained	-	NC_000003.12:g.119863599G>A	ExAC,gnomAD
rs762651036	p.Arg306Gln	missense variant	-	NC_000003.12:g.119863598C>T	ExAC,TOPMed,gnomAD
rs775606264	p.Arg308Gln	missense variant	-	NC_000003.12:g.119863592C>T	ExAC,gnomAD
NCI-TCGA novel	p.Arg308Ter	stop gained	-	NC_000003.12:g.119863593G>A	NCI-TCGA
rs1336623593	p.Thr309Ala	missense variant	-	NC_000003.12:g.119863590T>C	gnomAD
rs769830542	p.Pro310Ser	missense variant	-	NC_000003.12:g.119863587G>A	ExAC,gnomAD
rs1189501362	p.Pro311Leu	missense variant	-	NC_000003.12:g.119863583G>A	TOPMed
rs1299887852	p.Ala313Ser	missense variant	-	NC_000003.12:g.119863578C>A	gnomAD
NCI-TCGA novel	p.Ala313Pro	missense variant	-	NC_000003.12:g.119863578C>G	NCI-TCGA
rs780806364	p.Ala315Val	missense variant	-	NC_000003.12:g.119863571G>A	ExAC,gnomAD
rs746618679	p.Ser318Arg	missense variant	-	NC_000003.12:g.119863563T>G	ExAC,gnomAD
rs72548709	p.Arg319His	missense variant	-	NC_000003.12:g.119863559C>T	ESP,ExAC,TOPMed,gnomAD
rs199730714	p.Arg319Cys	missense variant	-	NC_000003.12:g.119863560G>A	ESP,ExAC,TOPMed,gnomAD
COSM288436	p.Leu321Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119863554G>T	NCI-TCGA Cosmic
rs777620218	p.Thr326Ala	missense variant	-	NC_000003.12:g.119863539T>C	ExAC,gnomAD
rs370810641	p.Ala327Val	missense variant	-	NC_000003.12:g.119863535G>A	ESP,ExAC,gnomAD
rs753950587	p.Arg328Ter	stop gained	-	NC_000003.12:g.119863533G>A	ExAC,gnomAD
COSM6163065	p.Arg328Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119863532C>A	NCI-TCGA Cosmic
rs1388013918	p.Pro331Gln	missense variant	-	NC_000003.12:g.119863523G>T	TOPMed
NCI-TCGA novel	p.Pro331Leu	missense variant	-	NC_000003.12:g.119863523G>A	NCI-TCGA
rs766379974	p.Leu332Val	missense variant	-	NC_000003.12:g.119863521G>C	ExAC,gnomAD
rs1320887967	p.Ala336Val	missense variant	-	NC_000003.12:g.119863508G>A	TOPMed
rs750723548	p.His337Arg	missense variant	-	NC_000003.12:g.119863505T>C	ExAC,gnomAD
COSM6044508	p.Phe340LeuPheSerTerUnkUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000003.12:g.119863495A>-	NCI-TCGA Cosmic
NCI-TCGA novel	p.Asp341Ter	frameshift	-	NC_000003.12:g.119863494_119863495insA	NCI-TCGA
NCI-TCGA novel	p.Glu342Ter	stop gained	-	NC_000003.12:g.119863491C>A	NCI-TCGA
rs1314952657	p.Pro346Ser	missense variant	-	NC_000003.12:g.119863479G>A	gnomAD
rs767602302	p.Val348Ile	missense variant	-	NC_000003.12:g.119863473C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Val348Asp	missense variant	-	NC_000003.12:g.119863472A>T	NCI-TCGA
rs367873946	p.Lys349Arg	missense variant	-	NC_000003.12:g.119863469T>C	ESP,ExAC,TOPMed,gnomAD
rs367873946	p.Lys349Thr	missense variant	-	NC_000003.12:g.119863469T>G	ESP,ExAC,TOPMed,gnomAD
rs1247019169	p.Pro351Arg	missense variant	-	NC_000003.12:g.119863463G>C	TOPMed
rs759476802	p.Arg354Gln	missense variant	-	NC_000003.12:g.119863454C>T	ExAC,TOPMed,gnomAD
rs776291124	p.Thr356Ile	missense variant	-	NC_000003.12:g.119863448G>A	ExAC,gnomAD
rs201790494	p.Thr356Ala	missense variant	-	NC_000003.12:g.119863449T>C	1000Genomes
rs374033612	p.Pro357Ala	missense variant	-	NC_000003.12:g.119863446G>C	ESP,TOPMed
rs1347336963	p.Asn361Ser	missense variant	-	NC_000003.12:g.119863433T>C	TOPMed,gnomAD
rs1452045897	p.Asn361Asp	missense variant	-	NC_000003.12:g.119863434T>C	gnomAD
rs1260902406	p.Thr363Ile	missense variant	-	NC_000003.12:g.119863427G>A	TOPMed
rs1199213155	p.Gln365His	missense variant	-	NC_000003.12:g.119863420T>G	gnomAD
rs1424307475	p.Gln365Lys	missense variant	-	NC_000003.12:g.119863422G>T	TOPMed
rs1255291178	p.Asn370His	missense variant	-	NC_000003.12:g.119843342T>G	gnomAD
rs1212959347	p.Pro372Leu	missense variant	-	NC_000003.12:g.119843335G>A	gnomAD
rs376972717	p.Leu373Val	missense variant	-	NC_000003.12:g.119843333G>C	ESP,ExAC,TOPMed,gnomAD
rs376972717	p.Leu373Met	missense variant	-	NC_000003.12:g.119843333G>T	ESP,ExAC,TOPMed,gnomAD
rs760284146	p.Thr375Asn	missense variant	-	NC_000003.12:g.119843326G>T	ExAC,gnomAD
NCI-TCGA novel	p.Ile376Val	missense variant	-	NC_000003.12:g.119843324T>C	NCI-TCGA
rs1044741713	p.Ile378Thr	missense variant	-	NC_000003.12:g.119843317A>G	TOPMed
rs201010589	p.His381Arg	missense variant	-	NC_000003.12:g.119843308T>C	gnomAD
rs772550262	p.His381Tyr	missense variant	-	NC_000003.12:g.119843309G>A	ExAC,gnomAD
rs149631706	p.Arg383Gln	missense variant	-	NC_000003.12:g.119843302C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
COSM3426928	p.Ser389Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119843285A>G	NCI-TCGA Cosmic
rs200933546	p.Thr390Ala	missense variant	-	NC_000003.12:g.119843282T>C	1000Genomes,ExAC,TOPMed,gnomAD
rs369649606	p.Pro391Ser	missense variant	-	NC_000003.12:g.119843279G>A	ESP,TOPMed,gnomAD
rs369649606	p.Pro391Thr	missense variant	-	NC_000003.12:g.119843279G>T	ESP,TOPMed,gnomAD
rs780658325	p.Asn393Lys	missense variant	-	NC_000003.12:g.119843271A>C	ExAC,gnomAD
rs549169441	p.Ala394Gly	missense variant	-	NC_000003.12:g.119843269G>C	1000Genomes,ExAC,gnomAD
rs549169441	p.Ala394Asp	missense variant	-	NC_000003.12:g.119843269G>T	1000Genomes,ExAC,gnomAD
rs549169441	p.Ala394Val	missense variant	-	NC_000003.12:g.119843269G>A	1000Genomes,ExAC,gnomAD
rs201103601	p.Thr395Ala	missense variant	-	NC_000003.12:g.119843267T>C	ExAC,TOPMed,gnomAD
rs781064367	p.Ala396Thr	missense variant	-	NC_000003.12:g.119843264C>T	ExAC,gnomAD
rs139402886	p.Ala397Val	missense variant	-	NC_000003.12:g.119843260G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
COSM4112582	p.Ala397Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000003.12:g.119843261C>T	NCI-TCGA Cosmic
rs767410640	p.Thr402Ala	missense variant	-	NC_000003.12:g.119826847T>C	ExAC,TOPMed,gnomAD
rs202055878	p.Arg405Cys	missense variant	-	NC_000003.12:g.119826838G>A	ExAC,TOPMed,gnomAD
rs202055878	p.Arg405Gly	missense variant	-	NC_000003.12:g.119826838G>C	ExAC,TOPMed,gnomAD
rs141519181	p.Arg405His	missense variant	-	NC_000003.12:g.119826837C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1384008314	p.Thr408Ile	missense variant	-	NC_000003.12:g.119826828G>A	gnomAD
rs1405720494	p.Thr408Ala	missense variant	-	NC_000003.12:g.119826829T>C	gnomAD
rs775934133	p.Ala411Thr	missense variant	-	NC_000003.12:g.119826820C>T	ExAC,gnomAD
rs775934133	p.Ala411Ser	missense variant	-	NC_000003.12:g.119826820C>A	ExAC,gnomAD
rs1193074453	p.Ala414Val	missense variant	-	NC_000003.12:g.119826810G>A	gnomAD
rs201770515	p.Ala416Ser	missense variant	-	NC_000003.12:g.119826805C>A	1000Genomes,ExAC,gnomAD
rs1194528845	p.Ser417Phe	missense variant	-	NC_000003.12:g.119826801G>A	gnomAD
rs1194528845	p.Ser417Cys	missense variant	-	NC_000003.12:g.119826801G>C	gnomAD
rs771546683	p.Asn418Thr	missense variant	-	NC_000003.12:g.119826798T>G	ExAC,gnomAD
rs771546683	p.Asn418Ser	missense variant	-	NC_000003.12:g.119826798T>C	ExAC,gnomAD
rs1282597500	p.Ser419Ala	missense variant	-	NC_000003.12:g.119826796A>C	TOPMed,gnomAD
rs1222836539	p.Thr420Ala	missense variant	-	NC_000003.12:g.119826793T>C	gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0000772	Multiple congenital anomalies	group	CTD_human
C0001418	Adenocarcinoma	group	BEFREE;LHGDN
C0001430	Adenoma	group	BEFREE
C0002395	Alzheimer's Disease	disease	BEFREE;CTD_human;LHGDN;RGD
C0002726	Amyloidosis	disease	BEFREE
C0003850	Arteriosclerosis	disease	BEFREE
C0003865	Arthritis, Adjuvant-Induced	disease	CTD_human
C0004153	Atherosclerosis	disease	BEFREE
C0004936	Mental disorders	group	BEFREE
C0005586	Bipolar Disorder	disease	BEFREE;CTD_human;LHGDN;PSYGENET
C0005587	Depression, Bipolar	disease	BEFREE;CTD_human
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE
C0005699	Blast Phase	disease	LHGDN
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0006287	Bronchopulmonary Dysplasia	disease	BEFREE
C0007102	Malignant tumor of colon	disease	BEFREE
C0007107	Malignant neoplasm of larynx	disease	BEFREE
C0007115	Malignant neoplasm of thyroid	disease	BEFREE
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE
C0007134	Renal Cell Carcinoma	disease	BEFREE
C0007137	Squamous cell carcinoma	disease	BEFREE
C0007787	Transient Ischemic Attack	disease	BEFREE
C0009241	Cognition Disorders	group	CTD_human
C0009375	Colonic Neoplasms	group	LHGDN
C0009402	Colorectal Carcinoma	disease	BEFREE
C0009404	Colorectal Neoplasms	group	LHGDN
C0011265	Presenile dementia	disease	CTD_human
C0011570	Mental Depression	disease	BEFREE;PSYGENET;RGD
C0011573	Endogenous depression	disease	CTD_human
C0011581	Depressive disorder	disease	BEFREE;CTD_human;PSYGENET
C0011847	Diabetes	disease	BEFREE
C0011849	Diabetes Mellitus	group	BEFREE
C0011860	Diabetes Mellitus, Non-Insulin-Dependent	disease	BEFREE
C0011881	Diabetic Nephropathy	disease	BEFREE
C0013274	Patent ductus arteriosus	disease	BEFREE
C0014859	Esophageal Neoplasms	group	BEFREE
C0015625	Fanconi Anemia	disease	BEFREE
C0017636	Glioblastoma	disease	BEFREE
C0017638	Glioma	disease	BEFREE
C0018800	Cardiomegaly	phenotype	CTD_human
C0018801	Heart failure	disease	CTD_human
C0018802	Congestive heart failure	disease	CTD_human
C0019158	Hepatitis	disease	BEFREE
C0019163	Hepatitis B	disease	BEFREE;LHGDN
C0020179	Huntington Disease	disease	BEFREE
C0020538	Hypertensive disease	group	CTD_human;RGD
C0021670	insulinoma	disease	BEFREE
C0022660	Kidney Failure, Acute	disease	CTD_human
C0022680	Polycystic Kidney Diseases	group	BEFREE
C0023212	Left-Sided Heart Failure	disease	CTD_human
C0023418	leukemia	disease	BEFREE
C0023434	Chronic Lymphocytic Leukemia	disease	BEFREE
C0023467	Leukemia, Myelocytic, Acute	disease	BEFREE
C0023473	Myeloid Leukemia, Chronic	disease	BEFREE;LHGDN
C0023487	Acute Promyelocytic Leukemia	disease	BEFREE
C0023890	Liver Cirrhosis	disease	BEFREE
C0023903	Liver neoplasms	group	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0024713	Manic Disorder	disease	CTD_human
C0025149	Medulloblastoma	disease	LHGDN
C0025193	Melancholia	disease	CTD_human
C0025202	melanoma	disease	BEFREE;LHGDN
C0025517	Metabolic Diseases	group	LHGDN
C0026846	Muscular Atrophy	phenotype	CTD_human
C0027051	Myocardial Infarction	disease	BEFREE;CTD_human;RGD
C0027627	Neoplasm Metastasis	phenotype	BEFREE
C0027819	Neuroblastoma	group	BEFREE
C0029463	Osteosarcoma	disease	BEFREE
C0029838	Other specified types of schizophrenia, unspecified	disease	RGD
C0029925	Ovarian Carcinoma	disease	BEFREE
C0030297	Pancreatic Neoplasm	disease	LHGDN
C0030552	Paresis	phenotype	BEFREE
C0030567	Parkinson Disease	disease	BEFREE;LHGDN;RGD
C0031154	Peritonitis	disease	CTD_human
C0032000	Pituitary Adenoma	disease	BEFREE
C0032343	Poisoning	group	CTD_human
C0032460	Polycystic Ovary Syndrome	disease	BEFREE;LHGDN
C0032580	Adenomatous Polyposis Coli	disease	BEFREE
C0033578	Prostatic Neoplasms	group	BEFREE;CTD_human;LHGDN
C0036341	Schizophrenia	disease	BEFREE;CTD_human;LHGDN
C0036421	Systemic Scleroderma	disease	BEFREE
C0038220	Status Epilepticus	disease	RGD
C0038356	Stomach Neoplasms	group	LHGDN
C0039101	synovial sarcoma	disease	BEFREE
C0040100	Thymoma	disease	BEFREE
C0041696	Unipolar Depression	disease	BEFREE;CTD_human
C0042769	Virus Diseases	group	BEFREE
C0079541	Holoprosencephaly	disease	BEFREE
C0085742	Injuries, Acute Brain	group	CTD_human
C0086133	Depressive Syndrome	disease	CTD_human
C0151786	Muscle Weakness	phenotype	BEFREE
C0152013	Adenocarcinoma of lung (disorder)	disease	BEFREE
C0152018	Esophageal carcinoma	disease	BEFREE
C0154409	Recurrent major depressive episodes	disease	BEFREE
C0162557	Liver Failure, Acute	disease	BEFREE
C0178874	Tumor Progression	phenotype	BEFREE
C0202117	Low density lipoprotein cholesterol measurement	phenotype	GWASDB
C0220702	SCHIZOPHRENIA 1 (disorder)	disease	RGD
C0233514	Abnormal behavior	phenotype	BEFREE
C0235527	Heart Failure, Right-Sided	disease	CTD_human
C0235974	Pancreatic carcinoma	disease	BEFREE
C0236642	Pick Disease of the Brain	disease	BEFREE
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0268575	Isovaleryl-CoA dehydrogenase deficiency	disease	BEFREE
C0270611	Brain Injuries	group	CTD_human
C0270948	Neurogenic Muscular Atrophy	phenotype	CTD_human
C0272945	Brain Lacerations	disease	CTD_human
C0276496	Familial Alzheimer Disease (FAD)	disease	BEFREE;CTD_human
C0282126	Depression, Neurotic	disease	CTD_human
C0333641	Atrophic	phenotype	LHGDN
C0334634	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	disease	CTD_human;LHGDN
C0338106	Adenocarcinoma of colon	disease	BEFREE
C0338451	Frontotemporal dementia	disease	BEFREE
C0338656	Impaired cognition	disease	BEFREE
C0338831	Manic	disease	BEFREE;CTD_human
C0346647	Malignant neoplasm of pancreas	disease	BEFREE
C0346957	Disseminated Malignant Neoplasm	phenotype	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE;CTD_human
C0392885	High density lipoprotein measurement	phenotype	GWASCAT;GWASDB
C0400966	Non-alcoholic Fatty Liver Disease	disease	BEFREE
C0442874	Neuropathy	group	BEFREE
C0452047	Brain Injuries, Focal	group	CTD_human
C0494463	Alzheimer Disease, Late Onset	disease	BEFREE;CTD_human
C0497327	Dementia	disease	BEFREE;LHGDN
C0524851	Neurodegenerative Disorders	group	BEFREE;LHGDN
C0525045	Mood Disorders	group	BEFREE;LHGDN;PSYGENET
C0546126	Acute Confusional Senile Dementia	disease	CTD_human
C0546837	Malignant neoplasm of esophagus	disease	BEFREE
C0549473	Thyroid carcinoma	disease	BEFREE
C0585442	Osteosarcoma of bone	disease	BEFREE
C0595989	Carcinoma of larynx	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0598766	Leukemogenesis	disease	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0677932	Progressive Neoplastic Disease	phenotype	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0684249	Carcinoma of lung	disease	BEFREE
C0685938	Malignant neoplasm of gastrointestinal tract	disease	BEFREE
C0687150	Parathyroid Gland Adenocarcinoma	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0700095	Central neuroblastoma	disease	BEFREE
C0730328	Central Serous Chorioretinopathy	disease	BEFREE
C0750900	Alzheimer's Disease, Focal Onset	disease	CTD_human
C0750901	Alzheimer Disease, Early Onset	disease	CTD_human
C0751958	Lymphoma, Lymphocytic, Intermediate	disease	CTD_human
C0853193	Bipolar I disorder	disease	BEFREE
C0917805	Transient Cerebral Ischemia	disease	BEFREE
C0919267	ovarian neoplasm	disease	LHGDN
C0949664	Tauopathies	group	BEFREE;CTD_human
C0971858	Arthritis, Collagen-Induced	disease	CTD_human
C0993582	Arthritis, Experimental	disease	CTD_human
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1263846	Attention deficit hyperactivity disorder	disease	BEFREE
C1269683	Major Depressive Disorder	disease	BEFREE;PSYGENET
C1270972	Mild cognitive disorder	disease	BEFREE
C1292753	Primary Effusion Lymphoma	disease	LHGDN
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1383860	Cardiac Hypertrophy	phenotype	CTD_human
C1449646	Primary Peritonitis	disease	CTD_human
C1449647	Secondary Peritonitis	disease	CTD_human
C1527249	Colorectal Cancer	disease	BEFREE
C1565662	Acute Kidney Insufficiency	disease	CTD_human
C1656427	Early onset schizophrenia	disease	BEFREE
C1800706	Idiopathic Pulmonary Fibrosis	disease	BEFREE
C1839839	MAJOR AFFECTIVE DISORDER 2	disease	BEFREE
C1852197	MAJOR AFFECTIVE DISORDER 1	disease	BEFREE
C1866282	CEROID LIPOFUSCINOSIS, NEURONAL, 6	disease	CTD_human
C1959583	Myocardial Failure	disease	CTD_human
C1961112	Heart Decompensation	phenotype	CTD_human
C1970943	MAJOR AFFECTIVE DISORDER 4	disease	BEFREE
C1970945	MAJOR AFFECTIVE DISORDER 6	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE;LHGDN
C2609414	Acute kidney injury	disease	CTD_human
C2700438	MAJOR AFFECTIVE DISORDER 7	disease	BEFREE
C2700439	MAJOR AFFECTIVE DISORDER 8	disease	BEFREE
C2700440	MAJOR AFFECTIVE DISORDER 9	disease	BEFREE
C2931822	Nasopharyngeal carcinoma	disease	BEFREE
C3250443	MYOTONIC DYSTROPHY 1	disease	BEFREE
C3463824	MYELODYSPLASTIC SYNDROME	group	BEFREE
C3469521	FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	disease	BEFREE
C3489791	Parkinson Disease, Familial, Type 1	disease	BEFREE
C3539781	Progressive cGVHD	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0001085	RNA polymerase II transcription factor binding	IPI
GO:0002020	protease binding	IPI
GO:0002039	p53 binding	IDA
GO:0004672	protein kinase activity	IMP
GO:0004672	protein kinase activity	TAS
GO:0004674	protein serine/threonine kinase activity	ISS
GO:0004674	protein serine/threonine kinase activity	IDA
GO:0004674	protein serine/threonine kinase activity	IMP
GO:0004674	protein serine/threonine kinase activity	IBA
GO:0004674	protein serine/threonine kinase activity	NAS
GO:0004674	protein serine/threonine kinase activity	TAS
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IEA
GO:0008013	beta-catenin binding	IBA
GO:0008013	beta-catenin binding	IPI
GO:0016301	kinase activity	IDA
GO:0016301	kinase activity	TAS
GO:0019901	protein kinase binding	IPI
GO:0031625	ubiquitin protein ligase binding	IPI
GO:0034236	protein kinase A catalytic subunit binding	IPI
GO:0034452	dynactin binding	IPI
GO:0048156	tau protein binding	NAS
GO:0050321	tau-protein kinase activity	IDA
GO:0050321	tau-protein kinase activity	IBA
GO:0050321	tau-protein kinase activity	NAS
GO:0051059	NF-kappaB binding	IPI

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001837	epithelial to mesenchymal transition	IMP
GO:0001954	positive regulation of cell-matrix adhesion	IMP
GO:0005977	glycogen metabolic process	IDA
GO:0006468	protein phosphorylation	IDA
GO:0006468	protein phosphorylation	IMP
GO:0006468	protein phosphorylation	TAS
GO:0006983	ER overload response	IDA
GO:0007165	signal transduction	IBA
GO:0007212	dopamine receptor signaling pathway	NAS
GO:0007623	circadian rhythm	ISS
GO:0008286	insulin receptor signaling pathway	IBA
GO:0010508	positive regulation of autophagy	ISS
GO:0010628	positive regulation of gene expression	ISS
GO:0010822	positive regulation of mitochondrion organization	IMP
GO:0010975	regulation of neuron projection development	IBA
GO:0016055	Wnt signaling pathway	TAS
GO:0018105	peptidyl-serine phosphorylation	IDA
GO:0018107	peptidyl-threonine phosphorylation	IDA
GO:0021766	hippocampus development	IMP
GO:0030010	establishment of cell polarity	ISS
GO:0030010	establishment of cell polarity	TAS
GO:0030011	maintenance of cell polarity	ISS
GO:0030011	maintenance of cell polarity	TAS
GO:0030516	regulation of axon extension	ISS
GO:0031175	neuron projection development	IDA
GO:0031333	negative regulation of protein-containing complex assembly	IMP
GO:0031334	positive regulation of protein-containing complex assembly	IDA
GO:0032091	negative regulation of protein binding	IDA
GO:0032092	positive regulation of protein binding	ISS
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IC
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP
GO:0032515	negative regulation of phosphoprotein phosphatase activity	TAS
GO:0032886	regulation of microtubule-based process	IMP
GO:0035556	intracellular signal transduction	IDA
GO:0035556	intracellular signal transduction	TAS
GO:0036016	cellular response to interleukin-3	ISS
GO:0042752	regulation of circadian rhythm	ISS
GO:0043066	negative regulation of apoptotic process	IDA
GO:0043547	positive regulation of GTPase activity	IMP
GO:0045719	negative regulation of glycogen biosynthetic process	TAS
GO:0045732	positive regulation of protein catabolic process	IC
GO:0046777	protein autophosphorylation	IDA
GO:0046827	positive regulation of protein export from nucleus	IDA
GO:0048814	regulation of dendrite morphogenesis	ISS
GO:0050770	regulation of axonogenesis	ISS
GO:0060079	excitatory postsynaptic potential	NAS
GO:0070507	regulation of microtubule cytoskeleton organization	ISS
GO:0070507	regulation of microtubule cytoskeleton organization	IBA
GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	IMP
GO:0071109	superior temporal gyrus development	IMP
GO:0090090	negative regulation of canonical Wnt signaling pathway	ISS
GO:0090090	negative regulation of canonical Wnt signaling pathway	IC
GO:0090090	negative regulation of canonical Wnt signaling pathway	TAS
GO:0090090	negative regulation of canonical Wnt signaling pathway	IBA
GO:0097191	extrinsic apoptotic signaling pathway	ISS
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	ISS
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IBA
GO:0106027	neuron projection organization	ISS
GO:0150101	regulation of microtubule anchoring at centrosome	IMP
GO:1900034	regulation of cellular response to heat	TAS
GO:1900181	negative regulation of protein localization to nucleus	ISS
GO:1900271	regulation of long-term synaptic potentiation	ISS
GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISS
GO:1901215	negative regulation of neuron death	IDA
GO:1901216	positive regulation of neuron death	IDA
GO:1901984	negative regulation of protein acetylation	ISS
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP
GO:1904339	negative regulation of dopaminergic neuron differentiation	TAS
GO:1904646	cellular response to amyloid-beta	ISS
GO:1904781	positive regulation of protein localization to centrosome	IMP
GO:1904885	beta-catenin destruction complex assembly	TAS
GO:1904886	beta-catenin destruction complex disassembly	TAS
GO:2000077	negative regulation of type B pancreatic cell development	TAS
GO:2000300	regulation of synaptic vesicle exocytosis	EXP
GO:2000300	regulation of synaptic vesicle exocytosis	IDA
GO:2000300	regulation of synaptic vesicle exocytosis	IMP
GO:2000466	negative regulation of glycogen (starch) synthase activity	TAS

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005634	nucleus	IDA
GO:0005634	nucleus	IBA
GO:0005654	nucleoplasm	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005737	cytoplasm	IBA
GO:0005739	mitochondrion	IEA
GO:0005813	centrosome	IDA
GO:0005829	cytosol	IBA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0030424	axon	ISS
GO:0030424	axon	IBA
GO:0030425	dendrite	ISS
GO:0030877	beta-catenin destruction complex	TAS
GO:0030877	beta-catenin destruction complex	IDA
GO:0030877	beta-catenin destruction complex	IBA
GO:0098794	postsynapse	IEA
GO:0098978	glutamatergic synapse	EXP
GO:0098978	glutamatergic synapse	IDA
GO:0098978	glutamatergic synapse	IMP
GO:0098978	glutamatergic synapse	IBA
GO:1990909	Wnt signalosome	TAS

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1257604	PIP3 activates AKT signaling	IEA
R-HSA-1266738	Developmental Biology	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-1640170	Cell Cycle	IEA
R-HSA-1643685	Disease	TAS
R-HSA-195253	Degradation of beta-catenin by the destruction complex	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-196299	Beta-catenin phosphorylation cascade	TAS
R-HSA-198323	AKT phosphorylates targets in the cytosol	IEA
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	IEA
R-HSA-212165	Epigenetic regulation of gene expression	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	TAS
R-HSA-3371556	Cellular response to heat stress	TAS
R-HSA-373755	Semaphorin interactions	TAS
R-HSA-399956	CRMPs in Sema3A signaling	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	TAS
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	IEA
R-HSA-4791275	Signaling by WNT in cancer	TAS
R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	TAS
R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	TAS
R-HSA-4839744	truncated APC mutants destabilize the destruction complex	TAS
R-HSA-4839748	AMER1 mutants destabilize the destruction complex	TAS
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	TAS
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	TAS
R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5358351	Signaling by Hedgehog	IEA
R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	TAS
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	TAS
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	TAS
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	TAS
R-HSA-5610783	Degradation of GLI2 by the proteasome	IEA
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	TAS
R-HSA-5610787	Hedgehog 'off' state	TAS
R-HSA-5610787	Hedgehog 'off' state	IEA
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	TAS
R-HSA-69242	S Phase	IEA
R-HSA-69278	Cell Cycle, Mitotic	IEA
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	IEA
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8939902	Regulation of RUNX2 expression and activity	IEA
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-9006925	Intracellular signaling by second messengers	IEA

Drugs and compounds information

ID	Drug Name	Action	PubMed
C025603	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]	25433145
C048792	1,2-diacetylbenzene	1,2-diacetylbenzene affects the phosphorylation of and results in increased activity of GSK3B protein	28734998
C048792	1,2-diacetylbenzene	2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole inhibits the reaction [1,2-diacetylbenzene affects the phosphorylation of and results in increased activity of GSK3B protein]	28734998
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in decreased expression of GSK3B mRNA	23958786
D019813	1,2-Dimethylhydrazine	[chlorophyllin affects the reaction [1,2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein]	12628520
C532657	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of GSK3B protein]	26685284
C532657	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]]	28245986
C532657	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [dimethoxon results in increased phosphorylation of GSK3B protein]	31574243
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GSK3B protein	21705713
C495626	14-deoxy-11,12-didehydroandrographolide	14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]	30248417
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased activity of GSK3B protein]	19135050
D015056	1-Methyl-3-isobutylxanthine	14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]	30248417
D015056	1-Methyl-3-isobutylxanthine	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein	27475717; 30248417;
D015056	1-Methyl-3-isobutylxanthine	andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]	27475717
D015056	1-Methyl-3-isobutylxanthine	[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in decreased expression of GSK3B mRNA	30665118
D015056	1-Methyl-3-isobutylxanthine	[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of GSK3B protein	30665118
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased phosphorylation of GSK3B protein	22891246; 23911879;
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased phosphorylation of GSK3B protein]	23911879
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	bis(3)-cognitin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased phosphorylation of GSK3B protein]	22891246
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of GSK3B mRNA	28484287
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of GSK3B protein	28484287
D015655	1-Methyl-4-phenylpyridinium	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]]	20064577
D015655	1-Methyl-4-phenylpyridinium	IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]	20064577
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium promotes the reaction [ABL1 protein binds to and results in increased phosphorylation of and results in increased activity of GSK3B protein]	30165626
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium promotes the reaction [GSK3B protein binds to TFEB protein]	30165626
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased phosphorylation of GSK3B protein	22891246
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in increased activity of GSK3B protein	30165626
D015655	1-Methyl-4-phenylpyridinium	Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [GSK3B protein binds to TFEB protein]]	30165626
D015655	1-Methyl-4-phenylpyridinium	Imatinib Mesylate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in increased activity of GSK3B protein]	30165626
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein	26048653
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein	20064577
D015655	1-Methyl-4-phenylpyridinium	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]	20064577
D015655	1-Methyl-4-phenylpyridinium	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]	26048653
D015655	1-Methyl-4-phenylpyridinium	Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]	26048653
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]	30517707
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of GSK3B protein	19584227; 22801959; 23318440;
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	[ERBB2 gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased phosphorylation of GSK3B protein	20453058
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	[OGT mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased phosphorylation of GSK3B protein	23029544
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	[PTEN gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased phosphorylation of GSK3B protein	20453058
C477694	2,2',4,4',5-brominated diphenyl ether	2,2',4,4',5-brominated diphenyl ether results in decreased phosphorylation of and results in increased activity of GSK3B protein	24218147
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein]	20696143
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein]	20696143
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in decreased phosphorylation of GSK3B protein]	20937724
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased activity of GSK3B protein]	20937724
C505456	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]	18806606
C505456	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]	16716347
C505456	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one promotes the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]	15951400
C505456	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one results in increased phosphorylation of GSK3B protein	15951400
C093026	2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside	2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased phosphorylation of GSK3B protein]	23911879
C078765	2,3,5-(triglutathion-S-yl)hydroquinone	2,3,5-(triglutathion-S-yl)hydroquinone results in decreased expression of GSK3B protein modified form	30703377
C078765	2,3,5-(triglutathion-S-yl)hydroquinone	Lithium Chloride inhibits the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in decreased expression of GSK3B protein modified form]	30703377
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	2,4,5,2',4',5'-hexachlorobiphenyl results in decreased phosphorylation of GSK3B protein	20394812
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Neomycin results in increased phosphorylation of GSK3B protein]	15800129
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA1 protein results in increased phosphorylation of GSK3B protein]	19814765
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA2 protein results in increased phosphorylation of GSK3B protein]	19814765
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]]	20064577
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Polychlorinated Biphenyls analog results in decreased expression of GSK3B protein]	24361488
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein]	20696143
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of GSK3B protein]	14750165
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein]	17513037
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein]	20696143
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased activity of GSK3B protein	15942663; 19661225;
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein	21821001; 22046442; 26968795; 27867098;
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein] which results in decreased susceptibility to Bleomycin	19429264
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of GSK3B protein	15753396
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	GSK3B mutant form inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]	21821001
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	GSK3B results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21821001
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	Tamoxifen promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein]	22046442
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased phosphorylation of and results in increased activity of GSK3B protein]	17928571
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]	15845746
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]]	27050422
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in decreased activity of GSK3B protein]	20542495
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforafan results in increased phosphorylation of and results in decreased activity of GSK3B protein]	29353218
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]	26089345
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased activity of GSK3B protein	29353218
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein	16179367
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	GSK3B mRNA affects the susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21832246
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]	20064577
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]	23352507
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]	29723552
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]	26048653
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO results in increased phosphorylation of GSK3B protein]	17952604
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside analog results in increased phosphorylation of GSK3B protein]	24726523
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phytoestrogens results in increased phosphorylation of GSK3B protein]	24726523
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of GSK3B protein]	24231000
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene affects the expression of GSK3B mRNA	21346803
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in decreased expression of GSK3B protein	20157255
C029216	2-amino-3-methylimidazo(4,5-f)quinoline	[chlorophyllin affects the reaction [2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein]	12628520
C495818	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of GSK3B protein]	20053781
C495818	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]	20053781
C029955	2-nitrotoluene	2-nitrotoluene affects the expression of GSK3B mRNA	16460773
C529548	2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole	2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole inhibits the reaction [1,2-diacetylbenzene affects the phosphorylation of and results in increased activity of GSK3B protein]	28734998
C529548	2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole	2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole results in decreased activity of GSK3B protein	28734998
C529548	2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole	2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole results in decreased activity of GSK3B protein	23085120
C417520	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein	19486905
C417520	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]	31563592
C417520	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]	15753396
C417520	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein	19159680
C417520	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein	19159680
C417520	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein	15475000; 15942663; 15950778; 15979805; 18687779; 21711903;
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane results in decreased phosphorylation of GSK3B protein	22290291
C497286	3,4',5-trimethoxystilbene	3,4',5-trimethoxystilbene results in decreased phosphorylation of and results in increased expression of GSK3B protein	23921149
C546412	3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide	3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide results in increased phosphorylation of GSK3B protein	19694723
C035055	3,4-dihydroxyphenyllactic acid	3,4-dihydroxyphenyllactic acid inhibits the reaction [tert-Butylhydroperoxide results in decreased phosphorylation of GSK3B protein]	29128606
C562244	3-(5-(4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl)-2-trifluoromethylphenyl)-4-(1H-indol-3-yl)pyrrole-2,5-dione	3-(5-(4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl)-2-trifluoromethylphenyl)-4-(1H-indol-3-yl)pyrrole-2,5-dione results in decreased activity of GSK3B protein	21155605
C530773	3,5-diethoxycarbonyl-1,4-dihydrocollidine	3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased phosphorylation of and results in decreased activity of GSK3B protein	20512997
C025946	3-methyladenine	3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	30362509
C015392	3-nitropropionic acid	3-nitropropionic acid results in decreased phosphorylation of GSK3B protein	29753867
C015392	3-nitropropionic acid	Topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein]	29753867
C008745	4,4'-bisphenol F	4,4'-bisphenol F results in decreased expression of GSK3B mRNA	26186136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSK3B mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSK3B mRNA	27188386
C555021	4-acetylantroquinonol B	4-acetylantroquinonol B results in decreased phosphorylation of GSK3B protein	28408137
C552996	4-aminoethylamino-emodin	4-aminoethylamino-emodin binds to and results in decreased activity of GSK3B protein	19228266
C494356	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione results in decreased activity of GSK3B protein	24824809
C494356	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]	25453207
C494356	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]]	25453207
C494356	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione results in decreased activity of GSK3B protein	22785175
C494356	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione results in decreased activity of GSK3B protein	15950778; 23085120;
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of GSK3B mRNA	12419474
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased phosphorylation of GSK3B protein	24825450
C406734	4-methylene-2-octyl-5-oxofuran-3-carboxylic acid	4-methylene-2-octyl-5-oxofuran-3-carboxylic acid results in decreased phosphorylation of GSK3B protein	21442130
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein	12511591
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of GSK3B mRNA	20829426
C558635	5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-2,4-imidazolidinedione	5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-2,4-imidazolidinedione results in increased phosphorylation of and results in increased activity of GSK3B protein	30165626
C060298	5,7-dimethoxyflavone	5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein]	21554863
D043582	5-alpha-Dihydroprogesterone	5-alpha-Dihydroprogesterone results in decreased expression of GSK3B protein	17443805
C411425	5-aminoisoquinolinone	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]	23352507
C411425	5-aminoisoquinolinone	5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]	23352507
C426745	5-iodo-3-(2-azetidinylmethoxy)pyridine	[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]	21715663
C426745	5-iodo-3-(2-azetidinylmethoxy)pyridine	[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]	21715663
C426745	5-iodo-3-(2-azetidinylmethoxy)pyridine	[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in increased phosphorylation of GSK3B protein	21715663
C471843	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine results in decreased activity of GSK3B protein	15958644
C558286	6,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalose	6,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalose analog results in decreased phosphorylation of GSK3B protein	25148938
C558286	6,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalose	6,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalose analog results in increased expression of GSK3B mRNA	25148938
D015120	6-Aminonicotinamide	6-Aminonicotinamide inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
C584755	6-bromo-8-ethoxy-3-nitro-2H-chromene	6-bromo-8-ethoxy-3-nitro-2H-chromene results in decreased phosphorylation of GSK3B protein	30125547
C483321	6-bromoindirubin-3'-oxime	6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to GSK3B protein]]	28414160
C483321	6-bromoindirubin-3'-oxime	6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of GSK3B protein modified form]	28414160
C483321	6-bromoindirubin-3'-oxime	6-bromoindirubin-3'-oxime results in decreased activity of GSK3B protein	17991738
C483321	6-bromoindirubin-3'-oxime	6-bromoindirubin-3'-oxime results in increased phosphorylation of GSK3B protein	19727391
C483321	6-bromoindirubin-3'-oxime	Methotrexate promotes the reaction [6-bromoindirubin-3'-oxime results in increased phosphorylation of GSK3B protein]	19727391
C483321	6-bromoindirubin-3'-oxime	6-bromoindirubin-3'-oxime results in decreased activity of GSK3B protein	18624906; 22975441;
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to AKT1 protein]	19407222
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to MAPK1 protein binds to MAPK3 protein]	19407222
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [GSK3B protein binds to CTNNB1 protein]	19407222
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of GSK3B protein	19407222
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of GSK3B mRNA	20382639
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GSK3B mRNA	19150397
C557120	8-ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene	8-ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene results in decreased phosphorylation of GSK3B protein	30125547
D000082	Acetaminophen	Acetaminophen results in increased expression of GSK3B protein modified form	19679878
D000082	Acetaminophen	Acetaminophen results in increased phosphorylation of GSK3B protein	22687999; 25752611;
D000082	Acetaminophen	GSTM1 gene mutant form inhibits the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein]	22687999
D000082	Acetaminophen	PRKN gene mutant form affects the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein]	25752611
D000082	Acetaminophen	Acetaminophen affects the expression of GSK3B mRNA	16701773
D000082	Acetaminophen	Acetaminophen results in decreased phosphorylation of GSK3B protein	26767949
D000082	Acetaminophen	morin inhibits the reaction [Acetaminophen results in decreased phosphorylation of GSK3B protein]	26767949
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	25246272
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of GSK3B protein]	24968063
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased phosphorylation of GSK3B protein]	25246272
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]	19126599
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Chromium results in decreased phosphorylation of GSK3B protein]	18569013
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]	27658547
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of GSK3B gene	27153756
D016604	Aflatoxin B1	[CYP2A13 protein co-treated with Aflatoxin B1] results in increased phosphorylation of GSK3B protein	26084420
D016604	Aflatoxin B1	MIR138-1 mRNA alternative form inhibits the reaction [[CYP2A13 protein co-treated with Aflatoxin B1] results in increased phosphorylation of GSK3B protein]	26084420
C000593263	afuresertib	afuresertib results in decreased phosphorylation of GSK3B protein	28960945
C046926	AH 23848	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to AKT1 protein]	19407222
C046926	AH 23848	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to MAPK1 protein binds to MAPK3 protein]	19407222
C046926	AH 23848	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [GSK3B protein binds to CTNNB1 protein]	19407222
C046926	AH 23848	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of GSK3B protein	19407222
C000188	alachlor	[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein	19883720
C120793	alsterpaullone	alsterpaullone results in decreased activity of GSK3B protein	12534346
C120793	alsterpaullone	alsterpaullone results in decreased activity of GSK3B protein	16055726
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of GSK3B protein]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of GSK3B protein]]	25309793
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GSK3B mRNA	16483693
D000661	Amphetamine	GSK3B gene mutant form results in increased susceptibility to Amphetamine	20357757
D000661	Amphetamine	Amphetamine results in decreased expression of GSK3B protein	16144542
C030419	andrographolide	andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]	27475717
D000924	Anticholesteremic Agents	Anticholesteremic Agents results in decreased phosphorylation of GSK3B protein	28275691
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of GSK3B mRNA	24449571
C558369	antrocin	antrocin results in decreased phosphorylation of GSK3B protein	21158420
C526219	apple polyphenol extract	apple polyphenol extract results in decreased activity of GSK3B protein	16968061
C526219	apple polyphenol extract	apple polyphenol extract results in increased expression of GSK3B protein	16968061
D016718	Arachidonic Acid	[SB 216763 results in decreased activity of GSK3B protein] results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]	19620254
D016718	Arachidonic Acid	GSK3B protein mutant form results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]	19620254
C071942	arctigenin	arctigenin results in decreased phosphorylation of GSK3B protein	25380086
C071942	arctigenin	Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of GSK3B protein]	25380086
D001151	Arsenic	Arsenic results in decreased expression of GSK3B mRNA	29107899
D001151	Arsenic	Arsenic results in increased phosphorylation of GSK3B protein	22552367
D000077237	Arsenic Trioxide	3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	30362509
D000077237	Arsenic Trioxide	Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	25246272
D000077237	Arsenic Trioxide	Arsenic Trioxide inhibits the reaction [Sorafenib results in increased phosphorylation of GSK3B protein]	25416439
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased phosphorylation of GSK3B protein	25416439
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased expression of GSK3B mRNA	22521957
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased phosphorylation of and results in increased activity of GSK3B protein	23949314
D000077237	Arsenic Trioxide	[Arsenic Trioxide results in increased phosphorylation of and results in increased activity of GSK3B protein] which results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of CCND1 protein	23949314
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased phosphorylation of GSK3B protein	21278055; 25246272; 26966376; 30362509;
D000077237	Arsenic Trioxide	Deoxyglucose inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	25246272
D000077237	Arsenic Trioxide	GSK3B protein affects the susceptibility to Arsenic Trioxide	21278055
D000077237	Arsenic Trioxide	GSK3B protein modified form affects the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]	21278055
D000077237	Arsenic Trioxide	Palmitic Acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	30362509
D000077237	Arsenic Trioxide	Rosiglitazone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	30362509
D000077237	Arsenic Trioxide	Sorafenib inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GSK3B protein]	25416439
D000077237	Arsenic Trioxide	Taurine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	30362509
D000077237	Arsenic Trioxide	U 0126 inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	21278055
D000077237	Arsenic Trioxide	Arsenic Trioxide results in increased phosphorylation of GSK3B protein	30362509
D000077237	Arsenic Trioxide	MAP2K1 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	21278055
C015001	arsenite	arsenite metabolite results in increased expression of GSK3B mRNA	18242949
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in decreased expression of GSK3B mRNA	29523930
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in decreased phosphorylation of GSK3B protein	17191120
D017632	Asbestos, Serpentine	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of GSK3B protein]	26685284
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in increased phosphorylation of GSK3B protein	26685284
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of GSK3B protein]	24675465
D001205	Ascorbic Acid	Ascorbic Acid results in decreased expression of GSK3B mRNA	15372504
D001241	Aspirin	Aspirin results in decreased activity of GSK3B protein	19966835
D001241	Aspirin	Aspirin results in decreased phosphorylation of GSK3B protein	11593435
D001241	Aspirin	Aspirin results in increased phosphorylation of GSK3B protein	12813129
C050701	atipamezole	atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein]]	30597158
D001280	Atrazine	Atrazine results in increased expression of GSK3B mRNA	22378314
C049935	avobenzone	avobenzone results in increased phosphorylation of GSK3B protein	29981360
D001397	Azoxymethane	Azoxymethane results in increased phosphorylation of GSK3B protein	20681671
D001397	Azoxymethane	pterostilbene inhibits the reaction [Azoxymethane results in increased phosphorylation of GSK3B protein]	20681671
C006680	baicalein	baicalein results in decreased phosphorylation of GSK3B protein	22820424
C060988	baohuoside I	baohuoside I results in decreased phosphorylation of GSK3B protein	25119583
C487081	belinostat	belinostat results in increased phosphorylation of GSK3B protein	23671600
D001554	Benzene	Benzene affects the expression of and results in increased phosphorylation of GSK3B protein	30567741
D001554	Benzene	Benzene analog results in decreased activity of GSK3B protein	17764934
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the methylation of GSK3B intron	30157460
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased phosphorylation of GSK3B protein	30659931
D001564	Benzo(a)pyrene	AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of GSK3B mRNA]	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GSK3B mRNA	15034205
D001564	Benzo(a)pyrene	GSK3B protein affects the reaction [Benzo(a)pyrene results in increased expression of HK2 mRNA]	22100782
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol inhibits the reaction [ESR1 protein binds to GSK3B protein]]	26990689
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GSK3B protein modified form	30703377
D001599	Berberine	Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]	23954465
D001599	Berberine	Berberine results in increased phosphorylation of GSK3B protein	23954465
D001599	Berberine	Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]	20462044
C044887	beta-methylcholine	beta-methylcholine affects the expression of GSK3B mRNA	21179406
D001632	Bibenzyls	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]]	28245986
D001632	Bibenzyls	Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]	28245986
D001632	Bibenzyls	PARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]]	28245986
C516541	BI D1870	BI D1870 inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
C516541	BI D1870	BI D1870 results in decreased phosphorylation of GSK3B protein	21488662
C528260	bis(12)-hupyridone	bis(12)-hupyridone results in increased expression of GSK3B protein modified form	23085120
C577051	bis(3)-cognitin	bis(3)-cognitin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased phosphorylation of GSK3B protein]	22891246
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of GSK3B mRNA	26186136
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in decreased activity of GSK3B protein	16055726
C467001	bisindolylmaleimide IX	bisindolylmaleimide IX results in decreased activity of GSK3B protein	16055726
C006780	bisphenol A	[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in decreased expression of GSK3B mRNA	30665118
C006780	bisphenol A	[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of GSK3B protein	30665118
C006780	bisphenol A	bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of GSK3B protein]	28483554
C006780	bisphenol A	bisphenol A results in decreased phosphorylation of GSK3B protein	25637671; 26779933;
C006780	bisphenol A	bisphenol A results in increased phosphorylation of GSK3B protein	26923231
C006780	bisphenol A	bisphenol A promotes the reaction [Dietary Fats results in decreased phosphorylation of GSK3B protein]	25112833
C006780	bisphenol A	bisphenol A results in decreased expression of GSK3B mRNA	26186136
C006780	bisphenol A	bisphenol A results in decreased phosphorylation of GSK3B protein	25112833; 25963729; 28739533;
C006780	bisphenol A	bisphenol A results in increased expression of and results in decreased phosphorylation of GSK3B protein	25381574
C006780	bisphenol A	bisphenol A results in increased expression of GSK3B mRNA	25181051; 25381574; 25963729; 29097150;
C006780	bisphenol A	bisphenol A results in increased methylation of GSK3B gene	28505145
C006780	bisphenol A	Curcumin inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]	25963729
C006780	bisphenol A	Curcumin inhibits the reaction [bisphenol A results in increased expression of GSK3B mRNA]	25963729
C006780	bisphenol A	Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]	25963729
C006780	bisphenol A	Dietary Fats promotes the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]	25112833
C006780	bisphenol A	GSK3B mutant form inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]	25963729; 25963729;
C006780	bisphenol A	WNT3A protein affects the reaction [bisphenol A results in increased expression of and results in decreased phosphorylation of GSK3B protein]	25381574
D001761	Bleomycin	[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein] which results in decreased susceptibility to Bleomycin	19429264
D001761	Bleomycin	Bleomycin results in increased phosphorylation of GSK3B protein	19429264
D001761	Bleomycin	[Bleomycin results in increased phosphorylation of GSK3B protein] inhibits the reaction [GSK3B protein binds to and results in increased stability of NFKBIA protein]	19429264
D001786	Blood Glucose	[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased phosphorylation of GSK3B protein	24058562
D001786	Blood Glucose	[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of GSK3B protein	26116440
D001786	Blood Glucose	sodium bisulfide inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased phosphorylation of GSK3B protein]	24058562
C428117	BMS 191095	BMS 191095 results in increased phosphorylation of GSK3B protein	18212794
D000069286	Bortezomib	[Bortezomib co-treated with lonafarnib] results in decreased expression of GSK3B protein modified form	16118318
C050295	brazilein	brazilein results in decreased expression of GSK3B protein modified form	23948132
C099813	bromochloroacetic acid	bromochloroacetic acid affects the expression of GSK3B mRNA	16460773
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased phosphorylation of GSK3B protein	18552690
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in increased phosphorylation of GSK3B protein	22552774
C027561	butylbenzyl phthalate	HDAC6 mutant form inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of GSK3B protein]	22552774
C038091	butylparaben	butylparaben results in decreased phosphorylation of GSK3B protein	29319206
D002104	Cadmium	Cadmium results in increased phosphorylation of GSK3B protein	22884995
D002104	Cadmium	CAT protein inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]	22884995
D002104	Cadmium	GSK3B mutant form results in decreased susceptibility to Cadmium	25273023
D002104	Cadmium	[GSK3B mutant form results in decreased susceptibility to Cadmium] which results in decreased expression of ABCC1 mRNA	25273023
D002104	Cadmium	[GSK3B mutant form results in decreased susceptibility to Cadmium] which results in decreased expression of ABCC1 protein	25273023
D002104	Cadmium	SOD1 protein inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]	22884995
D002104	Cadmium	SOD2 protein inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]	22884995
D002104	Cadmium	Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]	19126599
D002104	Cadmium	Cadmium results in increased phosphorylation of GSK3B protein	19126599
D002104	Cadmium	GSK3B protein results in increased susceptibility to Cadmium	19126599
D002104	Cadmium	Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]	27658547
D002104	Cadmium	[Cadmium co-treated with rottlerin] results in decreased expression of GSK3B protein	27658547
D002104	Cadmium	GSK3B protein affects the reaction [Cadmium results in increased cleavage of PARP1 protein]	27658547
D002104	Cadmium	GSK3B protein affects the reaction [Cadmium results in increased expression of DDIT3 protein]	27658547
D002104	Cadmium	GSK3B protein affects the reaction [Cadmium results in increased expression of HMOX1 protein]	27658547
D002104	Cadmium	GSK3B protein affects the susceptibility to Cadmium	27658547
D002104	Cadmium	Lithium Chloride promotes the reaction [Cadmium results in increased phosphorylation of GSK3B protein]	27658547
D002104	Cadmium	rottlerin inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]	27658547
D019256	Cadmium Chloride	Cadmium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein	28527916
D019256	Cadmium Chloride	Cadmium Chloride results in increased phosphorylation of GSK3B protein	24057571; 25118938;
D019256	Cadmium Chloride	ACHE mRNA promotes the reaction [Cadmium Chloride results in increased expression of GSK3B mRNA]	27377441
D019256	Cadmium Chloride	[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of GSK3B mRNA	27377441
D019256	Cadmium Chloride	[Cadmium Chloride results in decreased activity of CHRM1 protein] which results in increased expression of GSK3B mRNA	27377441
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GSK3B mRNA	26026611; 27377441;
D019256	Cadmium Chloride	CHRM1 mRNA inhibits the reaction [Cadmium Chloride results in increased expression of GSK3B mRNA]	27377441
D019256	Cadmium Chloride	GSK3B mutant form inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]	26026611
D019256	Cadmium Chloride	GSK3B mutant form inhibits the reaction [Cadmium Chloride results in increased activity of CASP7 protein]	26026611
D019256	Cadmium Chloride	GSK3B mutant form inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of MAPT protein]	26026611
D002110	Caffeine	Caffeine results in increased phosphorylation of GSK3B protein	21229324
D002110	Caffeine	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Caffeine results in increased phosphorylation of GSK3B protein]	21229324
D002110	Caffeine	Caffeine results in decreased phosphorylation of GSK3B protein	15126379
D002118	Calcium	Calcium results in increased phosphorylation of GSK3B protein	15800129
C059041	calyculin A	calyculin A promotes the reaction [Lithium Chloride results in increased phosphorylation of GSK3B protein]	12813129
D002211	Capsaicin	Capsaicin promotes the reaction [CEBPB protein binds to ATF3 protein binds to GSK3B protein]	20110283
D002211	Capsaicin	GSK3B mutant form inhibits the reaction [Capsaicin results in increased expression of GDF15 mRNA]	20110283
D002215	Captan	[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein	19883720
D002220	Carbamazepine	Carbamazepine affects the expression of GSK3B mRNA	24752500
D002248	Carbon Monoxide	Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein]	18037988
D002248	Carbon Monoxide	Carbon Monoxide results in increased phosphorylation of GSK3B protein	18845810
D000068579	Celecoxib	Celecoxib results in decreased phosphorylation of GSK3B protein	17257745
D000068579	Celecoxib	GSK3B mutant form inhibits the reaction [Celecoxib results in increased expression of GDF15]	17257745
D002518	Ceramides	Ceramides promotes the reaction [IGF1 protein results in decreased phosphorylation of and results in increased activity of GSK3B protein]	20696185
C019290	chaetoglobosins	chaetoglobosins results in increased phosphorylation of GSK3B protein	18040759
C019290	chaetoglobosins	Wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]	18040759
C473711	Chir 99021	Chir 99021 affects the phosphorylation of GSK3B protein	27752740
C473711	Chir 99021	Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [GSK3B protein binds to TFEB protein]]	30165626
C473711	Chir 99021	Chir 99021 promotes the reaction [GSK3B protein affects the expression of PPARGC1A protein]	29883716
C473711	Chir 99021	Chir 99021 promotes the reaction [GSK3B protein affects the phosphorylation of EIF2B5 protein]	29883716
C473711	Chir 99021	Chir 99021 results in decreased activity of GSK3B protein	30165626
D048271	Chitosan	[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein]	28732690
C084597	chlorcyclizine	chlorcyclizine results in decreased expression of GSK3B mRNA	21058326
D002719	Chlormethiazole	Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein]	24892905
C007020	chlorophyllin	[chlorophyllin affects the reaction [1,2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein]	12628520
C007020	chlorophyllin	[chlorophyllin affects the reaction [2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein]	12628520
D004390	Chlorpyrifos	[APOE protein results in increased susceptibility to Chlorpyrifos] which results in decreased phosphorylation of GSK3B protein	29404631
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of GSK3B mRNA	29665406
D004390	Chlorpyrifos	Chlorpyrifos results in increased phosphorylation of GSK3B protein	29404631
D004390	Chlorpyrifos	GSK3B protein affects the reaction [Chlorpyrifos results in increased phosphorylation of MAPT protein]	29665406
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of GSK3B mRNA	18668222
D002784	Cholesterol	Cholesterol results in increased phosphorylation of GSK3B protein	28275691
D002784	Cholesterol	CYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of GSK3B protein]	28275691
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GSK3B gene	20938992
D002857	Chromium	Acetylcysteine inhibits the reaction [Chromium results in decreased phosphorylation of GSK3B protein]	18569013
D002857	Chromium	Chromium results in decreased phosphorylation of GSK3B protein	18569013
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased phosphorylation of GSK3B protein	22552367
D000077407	Cilostazol	Cilostazol affects the phosphorylation of GSK3B protein	24254769
D000077407	Cilostazol	SIRT1 protein affects the reaction [Cilostazol affects the phosphorylation of GSK3B protein]	24254769
C012843	cinnamic aldehyde	cinnamic aldehyde results in decreased expression of GSK3B mRNA	28219650
C002471	cinobufagin	cinobufagin results in increased expression of GSK3B protein modified form	23164673
C002471	cinobufagin	GSK3B protein affects the susceptibility to cinobufagin	23164673
C002471	cinobufagin	GSK3B protein mutant form inhibits the reaction [cinobufagin results in decreased expression of RELA protein]	23164673
C002471	cinobufagin	GSK3B protein mutant form inhibits the reaction [cinobufagin results in increased expression of PARP1 protein modified form]	23164673
C002471	cinobufagin	SB 216763 inhibits the reaction [cinobufagin results in increased expression of GSK3B protein modified form]	23164673
D002945	Cisplatin	Cisplatin results in decreased expression of GSK3B mRNA	27594783
D002945	Cisplatin	Cisplatin results in decreased phosphorylation of GSK3B protein	21603599; 21821001;
D002945	Cisplatin	GSK3B mutant form inhibits the reaction [Cisplatin results in increased expression of LGALS3 protein]	21821001
D002945	Cisplatin	[NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of and affects the phosphorylation of GSK3B protein	30291867
D002945	Cisplatin	Cisplatin results in decreased expression of GSK3B mRNA	21151649
D003024	Clozapine	Clozapine results in increased phosphorylation of GSK3B protein	19440698
D003024	Clozapine	Clozapine results in increased expression of GSK3B protein	16144542; 19359144;
D003024	Clozapine	DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]	16144542
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin affects the phosphorylation of GSK3B protein	23497794
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin promotes the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]	24658657
C007095	cobaltiprotoporphyrin	tin protoporphyrin IX inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]]	24658657
C018021	cobaltous chloride	[lysophosphatidylethanolamine analog co-treated with cobaltous chloride] results in increased phosphorylation of GSK3B protein	25125499
D003042	Cocaine	Cocaine results in decreased phosphorylation of and results in increased activity of GSK3B protein	19328817
D003042	Cocaine	Cocaine results in increased activity of GSK3B protein	19328817
C024989	coenzyme Q10	coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]	22186599
D003078	Colchicine	Colchicine results in decreased expression of GSK3B mRNA	18255150
D003078	Colchicine	Colchicine affects the phosphorylation of and results in increased activity of GSK3B protein	15979805
D003078	Colchicine	Lithium inhibits the reaction [Colchicine affects the phosphorylation of and results in increased activity of GSK3B protein]	15979805
D005576	Colforsin	Colforsin results in increased phosphorylation of and results in decreased activity of GSK3B protein	15950778
D003300	Copper	[Copper binds to Thiosemicarbazones analog] which results in decreased activity of GSK3B protein	19122148
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of GSK3B mRNA	20971185
D003300	Copper	[Thiosemicarbazones binds to Copper] which results in increased expression of GSK3B protein	20931265
D019327	Copper Sulfate	Copper Sulfate results in increased expression of GSK3B mRNA	19549813
D004205	Cromolyn Sodium	[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein]	28732690
D004205	Cromolyn Sodium	Cromolyn Sodium results in decreased activity of GSK3B protein	23784744
C037886	cryptotanshinone	cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of GSK3B protein]	30208247
D003474	Curcumin	Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]	27645308
D003474	Curcumin	Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]	27645308
D003474	Curcumin	Curcumin results in decreased expression of GSK3B mRNA	27645308
D003474	Curcumin	Curcumin results in decreased phosphorylation of GSK3B protein	18790744
D003474	Curcumin	Curcumin results in increased expression of and results in increased phosphorylation of GSK3B protein	27645308
D003474	Curcumin	Curcumin results in increased expression of GSK3B protein	19573523
D003474	Curcumin	Curcumin results in decreased phosphorylation of GSK3B protein	18006147
D003474	Curcumin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]	29723552
D003474	Curcumin	Curcumin inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]	25963729
D003474	Curcumin	Curcumin inhibits the reaction [bisphenol A results in increased expression of GSK3B mRNA]	25963729
D003474	Curcumin	Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]	25963729
D003474	Curcumin	Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]	27966075; 29723552;
D003474	Curcumin	Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]	25541178
D003474	Curcumin	Curcumin results in decreased expression of GSK3B mRNA	25963729
D003474	Curcumin	Curcumin results in increased phosphorylation of GSK3B protein	25963729
C057862	cyanoginosin LR	cyanoginosin LR promotes the reaction [INS protein results in increased phosphorylation of and results in decreased activity of GSK3B protein]	28984034
C057862	cyanoginosin LR	cyanoginosin LR results in increased phosphorylation of and results in decreased activity of GSK3B protein	28984034
C057862	cyanoginosin LR	cyanoginosin LR results in increased phosphorylation of GSK3B protein	20421190
C057862	cyanoginosin LR	INS protein promotes the reaction [cyanoginosin LR results in increased phosphorylation of and results in decreased activity of GSK3B protein]	28984034
D000242	Cyclic AMP	GSK3B protein affects the reaction [Deamino Arginine Vasopressin results in increased abundance of Cyclic AMP]	20056751
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GSK3B mRNA]	11007951
C552889	cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine	cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in decreased phosphorylation of GSK3B protein	30597128
D016572	Cyclosporine	Cyclosporine results in decreased expression of GSK3B mRNA	22147139; 25562108;
D016572	Cyclosporine	Cyclosporine results in increased phosphorylation of GSK3B protein	22416070
D016572	Cyclosporine	[GSK3A protein co-treated with GSK3B protein] affects the reaction [Cyclosporine results in increased expression of SNAI1 protein]	22416070
D003634	DDT	Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of GSK3B protein]	24968063
D003634	DDT	DDT results in increased phosphorylation of GSK3B protein	24968063
D003894	Deamino Arginine Vasopressin	GSK3B protein affects the reaction [Deamino Arginine Vasopressin results in increased abundance of Cyclic AMP]	20056751
D003676	Deferoxamine	Deferoxamine inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
D003676	Deferoxamine	Deferoxamine results in decreased phosphorylation of GSK3B protein	25246272
C107676	deguelin	deguelin results in decreased phosphorylation of GSK3B protein	19336726; 21472727;
D003847	Deoxyglucose	Deoxyglucose inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	25246272
D003847	Deoxyglucose	Deoxyglucose inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
C007262	deoxynivalenol	deoxynivalenol results in increased phosphorylation of GSK3B protein	15976193
C007262	deoxynivalenol	deoxynivalenol results in increased expression of GSK3B protein	30690062
D003907	Dexamethasone	14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]	30248417
D003907	Dexamethasone	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein	27475717; 30248417;
D003907	Dexamethasone	andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]	27475717
D003907	Dexamethasone	Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]	20462044
D003907	Dexamethasone	[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in decreased expression of GSK3B mRNA	30665118
D003907	Dexamethasone	[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of GSK3B protein	30665118
D003907	Dexamethasone	Dexamethasone results in decreased expression of GSK3B mRNA	20462044
D003907	Dexamethasone	Dexamethasone results in increased expression of and results in decreased phosphorylation of GSK3B protein	20501703
D003907	Dexamethasone	Dexamethasone results in increased ubiquitination of GSK3B protein	24451375
D020927	Dexmedetomidine	atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein]]	30597158
D020927	Dexmedetomidine	Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein]	30597158
D020927	Dexmedetomidine	Dexmedetomidine inhibits the reaction [Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein]	31187143
D020927	Dexmedetomidine	Dexmedetomidine results in increased phosphorylation of GSK3B protein	30597158
C028009	diallyl disulfide	diallyl disulfide results in increased phosphorylation of GSK3B protein	23663050
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of GSK3B protein modified form	29626521
C042577	diallyl trisulfide	diallyl trisulfide results in increased phosphorylation of GSK3B protein	23663050
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of GSK3B protein	23453443
D003976	Diazinon	[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein	19883720
D003976	Diazinon	Diazinon affects the expression of GSK3B mRNA	22546817
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased phosphorylation of GSK3B protein	22552774
D003993	Dibutyl Phthalate	HDAC6 mutant form inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of GSK3B protein]	22552774
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of GSK3B mRNA	21266533
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene affects the activity of GSK3B protein	25386960
D004008	Diclofenac	Diclofenac affects the expression of GSK3B mRNA	24752500
C026398	dictamnine	dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]	30266538
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of GSK3B mRNA	26924002
C552234	didymin	didymin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]	30928401
D004041	Dietary Fats	Dietary Fats results in decreased expression of GSK3B mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in increased expression of GSK3B mRNA	24812660; 27260466;
D004041	Dietary Fats	Dietary Fats results in increased expression of GSK3B protein	30826251
D004041	Dietary Fats	[Diethylnitrosamine co-treated with Dietary Fats] results in increased expression of GSK3B protein	30826251
D004041	Dietary Fats	Quercetin inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]	27260466
D004041	Dietary Fats	Resveratrol inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]	24812660; 27260466;
D004041	Dietary Fats	Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]	27260466
D004041	Dietary Fats	bisphenol A promotes the reaction [Dietary Fats results in decreased phosphorylation of GSK3B protein]	25112833
D004041	Dietary Fats	Dietary Fats promotes the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]	25112833
D004041	Dietary Fats	Dietary Fats results in decreased phosphorylation of GSK3B protein	25112833
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased phosphorylation of GSK3B protein	30944277
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate inhibits the reaction [INS1 protein results in increased phosphorylation of GSK3B protein]	28526321
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased phosphorylation of GSK3B protein	22610992
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased phosphorylation of GSK3B protein	29669060
D004051	Diethylhexyl Phthalate	MK 2206 inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of GSK3B protein]	29669060
D004052	Diethylnitrosamine	CTNNB1 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein]	20583210
D004052	Diethylnitrosamine	Diethylnitrosamine affects the phosphorylation of GSK3B protein	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Dietary Fats] results in increased expression of GSK3B protein	30826251
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased phosphorylation of GSK3B protein	20583210
D004052	Diethylnitrosamine	5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein]	21554863
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of GSK3B protein modified form	19931519
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased phosphorylation of GSK3B protein	21554863
D004052	Diethylnitrosamine	morin inhibits the reaction [Diethylnitrosamine results in increased expression of GSK3B protein modified form]	19931519
C002302	dimethoxon	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [dimethoxon results in increased phosphorylation of GSK3B protein]	31574243
C002302	dimethoxon	dimethoxon results in increased phosphorylation of GSK3B protein	31574243
D004127	Dimethylhydrazines	[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein]	28732690
D004127	Dimethylhydrazines	Dimethylhydrazines results in increased expression of GSK3B protein	28732690
C024629	dimethyl phthalate	dimethyl phthalate results in decreased expression of GSK3B mRNA	26924002
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of GSK3B mRNA	17374397
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of GSK3B mRNA	28219650
D015232	Dinoprostone	cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of GSK3B protein]	30208247
D015232	Dinoprostone	Dinoprostone results in decreased expression of GSK3B protein	30208247
D015232	Dinoprostone	Dinoprostone results in increased phosphorylation of GSK3B protein	18395713
D015232	Dinoprostone	Dinoprostone results in increased phosphorylation of GSK3B protein	20578217
D004221	Disulfiram	Disulfiram results in decreased expression of GSK3B mRNA	20530235
D016291	Dizocilpine Maleate	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]	31563592
D016291	Dizocilpine Maleate	Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein	31563592
D016291	Dizocilpine Maleate	Dizocilpine Maleate results in increased expression of GSK3B mRNA	31563592
D016291	Dizocilpine Maleate	Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]	31563592
D016291	Dizocilpine Maleate	Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]	31563592
D016291	Dizocilpine Maleate	Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]	31563592
D016291	Dizocilpine Maleate	Dizocilpine Maleate results in increased phosphorylation of GSK3B protein	15877933
D004280	Dobutamine	GSK3B gene mutant form affects the susceptibility to Dobutamine	17901358
C516138	dorsomorphin	dorsomorphin inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of GSK3B protein]	22062806
C516138	dorsomorphin	dorsomorphin inhibits the reaction [Resveratrol results in decreased activity of GSK3B protein]	19620254
C516138	dorsomorphin	dorsomorphin inhibits the reaction [Resveratrol results in increased phosphorylation of GSK3B protein]	19620254
C516138	dorsomorphin	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSK3B mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSK3B mRNA	27188386
C516138	dorsomorphin	dorsomorphin inhibits the reaction [[Resveratrol results in increased phosphorylation of GSK3B protein] which results in increased uptake of Glucose]	22180358
D004317	Doxorubicin	Doxorubicin results in increased phosphorylation of GSK3B protein	17339365
D004317	Doxorubicin	methylselenic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]	17339365
D004317	Doxorubicin	Selenium inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]	17339365
D004317	Doxorubicin	Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein]	18037988
D004317	Doxorubicin	Doxorubicin results in decreased phosphorylation of GSK3B protein	18037988
D013759	Dronabinol	Dronabinol results in decreased phosphorylation of GSK3B protein	29082320
D013759	Dronabinol	[Dronabinol results in increased susceptibility to Dronabinol] which results in decreased phosphorylation of GSK3B protein	29082320
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal results in increased expression of and results in decreased phosphorylation of GSK3B protein	28548306
D004365	Drugs, Chinese Herbal	PPP2CA protein affects the reaction [Drugs, Chinese Herbal results in decreased phosphorylation of GSK3B protein]	28548306
D004441	Ecdysterone	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]	26048653
D004441	Ecdysterone	Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]	26048653
D004656	Enalapril	Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]	18806606
D004726	Endosulfan	[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein	19883720
D004726	Endosulfan	Endosulfan results in increased expression of GSK3B mRNA	29391264
C044101	endotoxin, Escherichia coli	[endotoxin, Escherichia coli results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein	23755222
C044101	endotoxin, Escherichia coli	malvidin promotes the reaction [[endotoxin, Escherichia coli results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein]	23755222
C040996	enkephalin-Leu, Ala(2)-Arg(6)-	enkephalin-Leu, Ala(2)-Arg(6)- results in increased phosphorylation of GSK3B protein	23651617
C118739	entinostat	entinostat results in decreased expression of GSK3B mRNA	26272509
C118739	entinostat	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSK3B mRNA	27188386
C038939	enzacamene	enzacamene results in increased phosphorylation of GSK3B protein	30597193
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased phosphorylation of GSK3B protein	16968065
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GSK3B mRNA	22079256
D000069347	Erlotinib Hydrochloride	Erlotinib Hydrochloride results in decreased expression of GSK3B protein modified form	30136359
C472787	erucylphospho-N,N,N-trimethylpropylammonium	erucylphospho-N,N,N-trimethylpropylammonium results in increased expression of GSK3B mRNA	29464035
D004958	Estradiol	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol inhibits the reaction [ESR1 protein binds to GSK3B protein]]	26990689
D004958	Estradiol	Estradiol affects the expression of GSK3B mRNA	22574217
D004958	Estradiol	Estradiol inhibits the reaction [ESR1 protein binds to GSK3B protein]	26990689
D004958	Estradiol	Estradiol results in increased phosphorylation of GSK3B protein	16076840
D004958	Estradiol	Wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]	16076840
D004958	Estradiol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]	15845746
D004958	Estradiol	Estradiol results in increased phosphorylation of GSK3B protein	15845746
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]	15845746
D004958	Estradiol	Estradiol inhibits the reaction [Progesterone results in decreased expression of GSK3B mRNA]	17170212
C007633	estragole	estragole results in increased phosphorylation of GSK3B protein	29054680
D004967	Estrogens	Estrogens deficiency results in decreased phosphorylation of and results in increased activity of GSK3B protein	29724995
D004967	Estrogens	GSK3B protein promotes the reaction [Estrogens deficiency results in decreased degradation of RNF144B protein]	29724995
D000431	Ethanol	ALDH2 protein inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein]	19429258
D000431	Ethanol	[Ethanol co-treated with sodium arsenite] results in increased phosphorylation of GSK3B protein	26220687
D000431	Ethanol	Ethanol results in decreased activity of and affects the phosphorylation of GSK3B protein	26014148
D000431	Ethanol	Ethanol results in increased phosphorylation of GSK3B protein	26220687
D000431	Ethanol	[sodium arsenite co-treated with Ethanol] results in increased phosphorylation of GSK3B protein	22872060
D000431	Ethanol	ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of GSK3B protein]	19332462
D000431	Ethanol	Chlormethiazole inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein]	24892905
D000431	Ethanol	Ethanol affects the splicing of GSK3B mRNA	30319688
D000431	Ethanol	Ethanol results in decreased phosphorylation of GSK3B protein	18377926; 19429258; 24892905; 25460735;
D000431	Ethanol	Ethanol results in increased phosphorylation of GSK3B protein	19332462; 22459179; 28962519;
D000431	Ethanol	NR1H4 gene mutant form inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein]	25460735
D000431	Ethanol	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Ethanol results in increased phosphorylation of GSK3B protein]	28962519
D000431	Ethanol	[Ethanol results in decreased susceptibility to INS1 protein] which results in increased activity of GSK3B protein	12700235
D000431	Ethanol	Ethanol results in increased activity of and results in decreased phosphorylation of GSK3B protein	12700235
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GSK3B mRNA	12655037; 15576828; 29097150;
D005013	Ethosuximide	DKK1 protein inhibits the reaction [Ethosuximide results in increased phosphorylation of GSK3B protein]	26420483
D005013	Ethosuximide	Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of GSK3B mRNA]	26420483
D005013	Ethosuximide	Ethosuximide results in decreased expression of GSK3B mRNA	26420483
D005013	Ethosuximide	Ethosuximide results in increased phosphorylation of GSK3B protein	26420483
D005023	Ethylene Chlorohydrin	Ethylene Chlorohydrin results in increased expression of GSK3B mRNA	26962056
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of GSK3B mRNA	23649840
D005038	Ethylnitrosourea	Ethylnitrosourea results in decreased expression of GSK3B protein	28549617
D005047	Etoposide	BCL2 protein affects the reaction [[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein]	19408126
D005047	Etoposide	Etoposide results in increased activity of GSK3B protein	19408126
D005047	Etoposide	[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein	19408126
D005054	Eugenol	Eugenol results in increased expression of GSK3B mRNA	17374397
D018683	Excitatory Amino Acid Agents	[Resveratrol co-treated with Excitatory Amino Acid Agents] results in increased phosphorylation of and results in decreased activity of GSK3B protein	20542495
D018690	Excitatory Amino Acid Agonists	Excitatory Amino Acid Agonists affects the phosphorylation of GSK3B protein	24675465
D018690	Excitatory Amino Acid Agonists	Resveratrol inhibits the reaction [Excitatory Amino Acid Agonists affects the phosphorylation of GSK3B protein]	24675465
D018690	Excitatory Amino Acid Agonists	Excitatory Amino Acid Agonists results in decreased expression of and results in decreased phosphorylation of GSK3B protein	31586550
D018690	Excitatory Amino Acid Agonists	Plant Extracts inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of GSK3B protein]	31586550
D018690	Excitatory Amino Acid Agonists	syringic acid inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of and results in decreased phosphorylation of GSK3B protein]	31586550
D018690	Excitatory Amino Acid Agonists	Ascorbic Acid inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of GSK3B protein]	24675465
D018690	Excitatory Amino Acid Agonists	Excitatory Amino Acid Agonists affects the phosphorylation of and results in increased activity of GSK3B protein	24675465
D018690	Excitatory Amino Acid Agonists	GSK3B protein results in increased susceptibility to Excitatory Amino Acid Agonists	24675465
D018690	Excitatory Amino Acid Agonists	SB 216763 inhibits the reaction [Excitatory Amino Acid Agonists affects the phosphorylation of GSK3B protein]	24675465
D015738	Famotidine	Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]	31563592
D015738	Famotidine	Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]	31563592
D017313	Fenretinide	6-Aminonicotinamide inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
D017313	Fenretinide	Acetylcysteine inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
D017313	Fenretinide	BI D1870 inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
D017313	Fenretinide	Deferoxamine inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
D017313	Fenretinide	Deoxyglucose inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
D017313	Fenretinide	Fenretinide results in increased phosphorylation of GSK3B protein	25246272
D017313	Fenretinide	GSK3B protein mutant form inhibits the reaction [Fenretinide results in increased expression of HMOX1 protein]	25246272
D017313	Fenretinide	GSK3B protein mutant form inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
D017313	Fenretinide	S-ethyl glutathione inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
D017313	Fenretinide	U 0126 inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
D017313	Fenretinide	Fenretinide results in decreased expression of GSK3B mRNA	28973697
C020748	ferrous sulfate	ferrous sulfate results in increased phosphorylation of GSK3B protein	19608791
C082360	fipronil	fipronil results in decreased phosphorylation of GSK3B protein	21296133
C082360	fipronil	GSK3B protein affects the susceptibility to fipronil	21296133
C082360	fipronil	kenpaullone inhibits the reaction [fipronil results in decreased phosphorylation of GSK3B protein]	21296133
C082360	fipronil	Lithium Chloride inhibits the reaction [fipronil results in decreased phosphorylation of GSK3B protein]	21296133
D005473	Fluoxetine	Fluoxetine results in increased expression of GSK3B protein	19359144
D005492	Folic Acid	Folic Acid results in increased expression of GSK3B mRNA	25006883
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GSK3B gene	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of GSK3B mRNA	23649840
C058728	fosbretabulin	fosbretabulin results in decreased expression of GSK3B protein modified form	18434188
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]	23170834
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [gypenoside analog results in increased phosphorylation of GSK3B protein]	24726523
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Phytoestrogens results in increased phosphorylation of GSK3B protein]	24726523
C000599091	fumosorinone	fumosorinone results in increased phosphorylation of GSK3B protein	25796170
C052659	gambogic acid	gambogic acid results in decreased activity of GSK3B protein	19433130
D000077156	Gefitinib	Gefitinib results in decreased expression of GSK3B protein modified form	30136359
C056507	gemcitabine	gemcitabine results in increased phosphorylation of GSK3B protein	16570353
C007836	geraniol	geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein]	26165751
C007845	gingerol	gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]	27645308
C007845	gingerol	gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]	27645308
C007845	gingerol	gingerol results in increased expression of GSK3B protein	27645308
C007845	gingerol	GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]	18058799
C007845	gingerol	gingerol results in increased phosphorylation of GSK3B protein	26498061
C007845	gingerol	GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]	26498061
C007845	gingerol	GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]	26498061
C007845	gingerol	GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]	26498061
C007845	gingerol	GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]	26498061
C007845	gingerol	GSK3B protein results in increased susceptibility to gingerol	26498061
C049864	ginsenoside Re	ginsenoside Re results in increased phosphorylation of GSK3B protein	17885204
C026474	ginsenoside Rg2	dorsomorphin inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of GSK3B protein]	22062806
C026474	ginsenoside Rg2	ginsenoside Rg2 results in increased phosphorylation of GSK3B protein	22062806
C026474	ginsenoside Rg2	[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose	22062806
D005947	Glucose	Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]	23954465
D005947	Glucose	[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose	22062806
D005947	Glucose	Glucose results in decreased phosphorylation of GSK3B protein	23954465
D005947	Glucose	Glucose results in increased phosphorylation of GSK3B protein	23690508
D005947	Glucose	dorsomorphin inhibits the reaction [[Resveratrol results in increased phosphorylation of GSK3B protein] which results in increased uptake of Glucose]	22180358
D005947	Glucose	[Resveratrol results in increased phosphorylation of GSK3B protein] which results in increased uptake of Glucose	22180358
D005947	Glucose	Glucose results in decreased phosphorylation of and results in increased activity of GSK3B protein	18004065
D005947	Glucose	Glucose results in decreased phosphorylation of GSK3B protein	26054749
D005947	Glucose	GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of HMOX1 mRNA]]	29719095
D005947	Glucose	GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NFE2L2 protein]]	29719095
D005947	Glucose	GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NQO1 mRNA]]	29719095
D005947	Glucose	GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]	29719095
D005947	Glucose	MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B mRNA]	29719095
D005947	Glucose	MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B protein]	29719095
D005947	Glucose	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B mRNA	29719095
D005947	Glucose	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B protein	29719095
D005947	Glucose	Simvastatin inhibits the reaction [Glucose results in decreased phosphorylation of and results in increased activity of GSK3B protein]	18004065
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of GSK3B mRNA	22634610
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of GSK3B mRNA	22634610
D005978	Glutathione	GSK3B protein mutant form results in increased abundance of Glutathione	25246272
C000595148	GSK2110183	GSK2110183 results in decreased phosphorylation of GSK3B protein	24978597
C000595149	GSK2141795	GSK2141795 results in decreased phosphorylation of GSK3B protein	24978597
C000628859	GSK2193874	GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]	30517707
C000617853	GW 506033X	GW 506033X promotes the reaction [Potassium deficiency results in decreased phosphorylation of GSK3B protein]	19046382
C000617853	GW 506033X	GW 506033X results in decreased activity of GSK3B protein	19046382
C474918	gypenoside	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside analog results in increased phosphorylation of GSK3B protein]	24726523
C474918	gypenoside	Fulvestrant inhibits the reaction [gypenoside analog results in increased phosphorylation of GSK3B protein]	24726523
C474918	gypenoside	gypenoside analog results in increased phosphorylation of GSK3B protein	24726523
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of GSK3B protein]]	25309793
D006220	Haloperidol	DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein]	16144542
D006220	Haloperidol	Haloperidol results in increased expression of GSK3B mRNA	19359144
D006220	Haloperidol	Haloperidol results in increased expression of GSK3B protein	16144542; 19359144;
D006220	Haloperidol	Haloperidol results in increased phosphorylation of and results in decreased activity of GSK3B protein	19328817
D006581	Hexachlorobenzene	Hexachlorobenzene results in decreased activity of GSK3B protein	16679308
D006581	Hexachlorobenzene	[Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 protein	16679308
C062018	HU 211	HU 211 results in decreased phosphorylation of GSK3B protein	19509271
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of GSK3B mRNA	21179406
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein	31173752
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased phosphorylation of GSK3B protein	20302854
D006861	Hydrogen Peroxide	Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]	31173752
D006861	Hydrogen Peroxide	Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GSK3B protein]	20302854
D006861	Hydrogen Peroxide	Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]	31173752
D006861	Hydrogen Peroxide	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]	23352507
D006861	Hydrogen Peroxide	5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]	23352507
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein	23352507
C031927	hydroquinone	hydroquinone results in increased expression of and results in decreased phosphorylation of and results in increased activity of GSK3B protein	28886972
C031927	hydroquinone	IGF1 protein inhibits the reaction [hydroquinone results in decreased phosphorylation of GSK3B protein]	28886972
C031927	hydroquinone	Lithium Chloride inhibits the reaction [hydroquinone results in increased expression of GSK3B protein]	28886972
C107079	hymenialdisine	hymenialdisine results in decreased activity of GSK3B protein	21615147
C477872	IC 87114	IC 87114 results in decreased phosphorylation of GSK3B protein	16179367
C499403	icaritin	icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein]	30731080
C499403	icaritin	icaritin results in increased phosphorylation of GSK3B protein	30731080
D000068877	Imatinib Mesylate	Imatinib Mesylate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in increased activity of GSK3B protein]	30165626
D007093	Imidazoles	Imidazoles analog results in decreased activity of GSK3B protein	17764934
C474021	indirubin-3'-monoxime	indirubin-3'-monoxime results in decreased activity of GSK3B protein	12534346
D007213	Indomethacin	Indomethacin results in increased expression of GSK3B mRNA	18299717
D007501	Iron	[SB 216763 results in decreased activity of GSK3B protein] results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]	19620254
D007501	Iron	GSK3B protein mutant form results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]	19620254
D007545	Isoproterenol	Isoproterenol results in increased phosphorylation of GSK3B protein	31009642
D007545	Isoproterenol	plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]	31009642
D007545	Isoproterenol	Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]	31009642
D007545	Isoproterenol	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]	18806606
D007545	Isoproterenol	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]	16716347
D007545	Isoproterenol	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one promotes the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]	15951400
D007545	Isoproterenol	Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]	18806606
D007545	Isoproterenol	Isoproterenol results in decreased phosphorylation of GSK3B protein	18806606
D007545	Isoproterenol	Isoproterenol results in increased phosphorylation of GSK3B protein	15951400; 16716347; 31009642;
C538973	isosakuranetin	isosakuranetin results in decreased phosphorylation of and results in increased activity of GSK3B protein	26524968
C053401	kahweol	kahweol results in decreased phosphorylation of GSK3B protein	30205135
C053401	kahweol	kahweol results in increased phosphorylation of GSK3B protein	27424123
D007608	Kainic Acid	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]	25453207
D007608	Kainic Acid	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]]	25453207
D007608	Kainic Acid	Kainic Acid results in decreased activity of GSK3B protein	18619545
D007608	Kainic Acid	Kainic Acid results in decreased phosphorylation of GSK3B protein	25453207
D007608	Kainic Acid	Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]	25453207
C510621	KCC 009	KCC 009 results in decreased expression of GSK3B protein	16170020
C510621	KCC 009	KCC 009 results in decreased phosphorylation of and results in increased activity of GSK3B protein	16170020
C119620	kenpaullone	kenpaullone inhibits the reaction [fipronil results in decreased phosphorylation of GSK3B protein]	21296133
C119620	kenpaullone	kenpaullone results in decreased activity of GSK3B protein	12534346; 21111724;
C119620	kenpaullone	kenpaullone results in decreased phosphorylation of GSK3B protein	17993264
C119620	kenpaullone	kenpaullone results in decreased activity of GSK3B protein	18624906; 22975441;
D007649	Ketamine	Ketamine results in decreased phosphorylation of GSK3B protein	17952604
C063302	KN 62	KN 62 results in decreased activity of GSK3B protein	10998351
C073601	KT 5823	KT 5823 results in decreased activity of GSK3B protein	12534346
D007854	Lead	Lead affects the splicing of GSK3B mRNA	28903495
D007854	Lead	icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein]	30731080
D007854	Lead	[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein	30731080
C008261	lead acetate	lead acetate results in increased phosphorylation of GSK3B protein	27012722
C017461	lead nitrate	icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein]	30731080
C017461	lead nitrate	[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein	30731080
D007980	Levodopa	EPO protein inhibits the reaction [Levodopa results in decreased expression of GSK3B protein]	21683736
D007980	Levodopa	Levodopa results in decreased expression of GSK3B protein	21683736
D007980	Levodopa	Levodopa results in decreased phosphorylation of GSK3B protein	19786063
D044243	Linoleic Acids, Conjugated	Linoleic Acids, Conjugated results in decreased phosphorylation of GSK3B protein	19800873
D044243	Linoleic Acids, Conjugated	Linoleic Acids, Conjugated results in increased activity of GSK3B protein	19800873
C440499	lipopolysaccharide, Escherichia coli O111 B4	atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein]]	30597158
C440499	lipopolysaccharide, Escherichia coli O111 B4	Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein]	30597158
C440499	lipopolysaccharide, Escherichia coli O111 B4	lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein	30597158
C440499	lipopolysaccharide, Escherichia coli O111 B4	SB 216763 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein]	30597158
D008070	Lipopolysaccharides	Fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]	23170834
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of GSK3B protein modified form	23170834
D008070	Lipopolysaccharides	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]	23170834
D008070	Lipopolysaccharides	Wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]	23170834
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of GSK3B protein	18047562
D008070	Lipopolysaccharides	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of GSK3B protein]	18047562
D000069450	Liraglutide	Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]	31173752
D000069450	Liraglutide	Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]	31173752
D008094	Lithium	Lithium results in decreased activity of GSK3B protein	19932742
D008094	Lithium	Lithium inhibits the reaction [GSK3B protein binds to TP53 protein]	15475000
D008094	Lithium	Lithium promotes the reaction [sodium arsenite results in increased phosphorylation of GSK3B protein]	17849503
D008094	Lithium	Lithium results in decreased activity of GSK3B protein	10998351
D008094	Lithium	Lithium results in increased phosphorylation of GSK3B protein	15475000; 19440698;
D008094	Lithium	Magnesium affects the reaction [Lithium results in decreased activity of GSK3B protein]	10998351
D008094	Lithium	Lithium results in decreased activity of GSK3B protein	19621015
D008094	Lithium	[Lithium results in decreased activity of GSK3B protein] which results in increased activity of MTOR protein	17921520
D008094	Lithium	[Lithium results in decreased activity of GSK3B protein] which results in increased activity of NFE2L2 protein	18619545
D008094	Lithium	Lithium results in increased phosphorylation of and results in decreased activity of GSK3B protein	19328817
D008094	Lithium	Lithium results in decreased activity of GSK3B protein	16288908
D008094	Lithium	Lithium results in decreased phosphorylation of GSK3B protein	25433145
D008094	Lithium	Lithium results in increased expression of GSK3B mRNA	19359144
D008094	Lithium	Lithium results in increased expression of GSK3B protein	18296634; 19359144;
D008094	Lithium	Lithium results in increased phosphorylation of and results in decreased activity of GSK3B protein	15950778; 21711903;
D008094	Lithium	Lithium results in increased phosphorylation of GSK3B protein	18296634
D008094	Lithium	Lithium inhibits the reaction [Colchicine affects the phosphorylation of and results in increased activity of GSK3B protein]	15979805
D008094	Lithium	Lithium results in decreased activity of GSK3B protein	14534419; 17921520; 18619545; 20190034;
D018021	Lithium Chloride	Lithium Chloride results in decreased activity of GSK3B protein	19486905
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of SCN9A mRNA	19486905
D018021	Lithium Chloride	CTNNB1 protein affects the reaction [[Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 protein]	19274078
D018021	Lithium Chloride	GSK3B protein mutant form inhibits the reaction [Lithium Chloride results in decreased expression of and results in decreased activity of ACHE protein]	22944069
D018021	Lithium Chloride	GSK3B protein mutant form inhibits the reaction [Lithium Chloride results in increased degradation of ACHE protein]	22944069
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in decreased expression of GSK3B protein modified form]	30703377
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [fipronil results in decreased phosphorylation of GSK3B protein]	21296133
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [hydroquinone results in increased expression of GSK3B protein]	28886972
D018021	Lithium Chloride	Lithium Chloride promotes the reaction [quinocetone affects the phosphorylation of and results in decreased activity of GSK3B protein]	28343033
D018021	Lithium Chloride	Lithium Chloride results in decreased activity of and results in increased phosphorylation of GSK3B protein	22493441
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of and results in increased phosphorylation of GSK3B protein] which results in increased expression of and results in increased phosphorylation of CTNNB1 protein	22493441
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of and results in increased phosphorylation of GSK3B protein] which results in increased expression of EGFR mRNA	22493441
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of and results in increased phosphorylation of GSK3B protein] which results in increased expression of EGFR protein	22493441
D018021	Lithium Chloride	Lithium Chloride results in decreased activity of GSK3B protein	19101580; 19274078; 19823589; 22944069;
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]	15753396
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 mRNA	19274078
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 protein	19274078
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of HSPA1A protein alternative form	20090934
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of STARD7 mRNA	19679347
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of STARD7 protein	19679347
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of and results in increased phosphorylation of GSK3B protein	26990689
D018021	Lithium Chloride	Lithium Chloride results in decreased phosphorylation of GSK3B protein	20093106
D018021	Lithium Chloride	Lithium Chloride results in increased expression of and results in increased phosphorylation of and results in decreased activity of GSK3B protein	19196980
D018021	Lithium Chloride	Lithium Chloride results in increased expression of GSK3B protein modified form	22944069; 30703377;
D018021	Lithium Chloride	Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein	17868649; 19679347;
D018021	Lithium Chloride	Lithium Chloride results in increased phosphorylation of GSK3B protein	18830594; 20696143; 21278055;
D018021	Lithium Chloride	PIK3CA protein affects the reaction [Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein]	19196980
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]	27050422
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [Paraquat results in decreased phosphorylation of GSK3B protein]	30171970
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [perfluorooctane sulfonic acid results in decreased phosphorylation of GSK3B protein]	27018151
D018021	Lithium Chloride	Lithium Chloride results in decreased activity of GSK3B protein	15364539; 15585669; 19442631; 20694829;
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of AHR mRNA	21498875
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of AXIN2 mRNA	21498875
D018021	Lithium Chloride	Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein	19440036; 19582394;
D018021	Lithium Chloride	[Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in decreased expression of SNAI1 protein	19440036
D018021	Lithium Chloride	[Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased localization of CTNNB1 protein	19582394
D018021	Lithium Chloride	[[Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased localization of CTNNB1 protein] which results in increased expression of GIP mRNA	19582394
D018021	Lithium Chloride	Lithium Chloride results in increased phosphorylation of GSK3B protein	27018151
D018021	Lithium Chloride	Lithium Chloride results in increased stability of GSK3B protein	19448134
D018021	Lithium Chloride	calyculin A promotes the reaction [Lithium Chloride results in increased phosphorylation of GSK3B protein]	12813129
D018021	Lithium Chloride	Lithium Chloride affects the phosphorylation of GSK3B protein	21364661
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [manganese chloride results in decreased phosphorylation of and results in increased activity of GSK3B protein]	24464479
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein]	20807582
D018021	Lithium Chloride	Lithium Chloride promotes the reaction [Cadmium results in increased phosphorylation of GSK3B protein]	27658547
D018021	Lithium Chloride	Lithium Chloride results in decreased activity of GSK3B protein	15247282; 18972237;
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]	20937724
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein	18972237
D018021	Lithium Chloride	[[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein] which affects the expression of GJA1 protein	18972237
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of GSK3B mRNA	18932008
D018021	Lithium Chloride	Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein	12813129; 26459185;
D018021	Lithium Chloride	Lithium Chloride results in increased phosphorylation of GSK3B protein	23651617; 27658547; 28759639;
D018021	Lithium Chloride	Lithium Chloride results in decreased activity of [GSK3A protein binds to GSK3B protein]	16076840
D018021	Lithium Chloride	Lithium Chloride results in decreased activity of GSK3B protein	16055726; 17210701; 17250809; 18624906; 18687779; 19228266; 19268480; 19403565; 20090934; 20937724; 21498875; 23326414; 23872260;
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1	23872260
D008095	Lithocholic Acid	Lithocholic Acid results in increased phosphorylation of and results in decreased activity of GSK3B protein	20512997
C115354	lonafarnib	[Bortezomib co-treated with lonafarnib] results in decreased expression of GSK3B protein modified form	16118318
D019808	Losartan	Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein]	22982863
D008148	Lovastatin	Lovastatin results in decreased phosphorylation of GSK3B protein	17234346
D008148	Lovastatin	Lovastatin results in increased phosphorylation of GSK3B protein	19741129
C010480	lupeol	lupeol binds to GSK3B protein	18222664
C008301	lysophosphatidylethanolamine	[lysophosphatidylethanolamine analog co-treated with cobaltous chloride] results in increased phosphorylation of GSK3B protein	25125499
D008274	Magnesium	Magnesium affects the reaction [Lithium results in decreased activity of GSK3B protein]	10998351
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles results in decreased expression of GSK3B mRNA	24525745
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of GSK3B mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] affects the expression of GSK3B mRNA	26378955
D008294	Malathion	Malathion results in increased expression of GSK3B mRNA	25449180
D008298	Maleates	Maleates results in decreased phosphorylation of GSK3B protein	21976531
C065861	malvidin	malvidin promotes the reaction [[endotoxin, Escherichia coli results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein]	23755222
C013099	mancozeb	[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein	19883720
D008344	Maneb	[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein	19883720
C025340	manganese chloride	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in decreased phosphorylation of GSK3B protein]	20937724
C025340	manganese chloride	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased activity of GSK3B protein]	20937724
C025340	manganese chloride	GSK3B protein affects the reaction [manganese chloride results in increased phosphorylation of MAPT protein]	20937724
C025340	manganese chloride	Lithium Chloride inhibits the reaction [manganese chloride results in decreased phosphorylation of and results in increased activity of GSK3B protein]	24464479
C025340	manganese chloride	[Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]	20937724
C025340	manganese chloride	manganese chloride results in decreased phosphorylation of and results in increased activity of GSK3B protein	24464479
C025340	manganese chloride	manganese chloride results in decreased phosphorylation of GSK3B protein	20937724
C025340	manganese chloride	manganese chloride results in increased activity of GSK3B protein	20937724
C078290	manzamine A	manzamine A results in decreased activity of GSK3B protein	22050263
D008550	Melatonin	Melatonin inhibits the reaction [Wortmannin results in decreased expression of GSK3B protein modified form]	15842767
D008627	Mercuric Chloride	GSK3B protein promotes the reaction [Mercuric Chloride results in increased activity of BAX protein]	22785175
D008627	Mercuric Chloride	GSK3B protein promotes the reaction [Mercuric Chloride results in increased cleavage of CASP3 protein]	22785175
D008687	Metformin	Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]	30928401
D008687	Metformin	Metformin results in increased phosphorylation of GSK3B protein	21054339
D008694	Methamphetamine	Methamphetamine results in increased phosphorylation of GSK3B protein	29981415
D008694	Methamphetamine	Rosiglitazone inhibits the reaction [Methamphetamine results in increased phosphorylation of GSK3B protein]	29981415
D008694	Methamphetamine	TWS 119 inhibits the reaction [Methamphetamine results in increased phosphorylation of GSK3B protein]	29981415
D008694	Methamphetamine	Methamphetamine results in decreased phosphorylation of GSK3B protein	30367931
D008701	Methapyrilene	Methapyrilene results in increased expression of GSK3B mRNA	16393664
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GSK3B gene	20938992
D008727	Methotrexate	Methotrexate promotes the reaction [6-bromoindirubin-3'-oxime results in increased phosphorylation of GSK3B protein]	19727391
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	GSK3B protein mutant form inhibits the reaction [methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in increased expression of HMOX1 protein]	25246272
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	GSK3B protein mutant form inhibits the reaction [methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in increased phosphorylation of GSK3B protein]	25246272
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in increased phosphorylation of GSK3B protein	25246272
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of GSK3B mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GSK3B mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GSK3B mRNA	20061341
C004925	methylmercuric chloride	methylmercuric chloride results in decreased phosphorylation of and results in increased activity of GSK3B protein	28821999
C004925	methylmercuric chloride	methylmercuric chloride results in decreased phosphorylation of GSK3B protein	29258870
C004925	methylmercuric chloride	methylmercuric chloride results in increased phosphorylation of GSK3B protein	28736149
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of GSK3B mRNA	23649840
D008770	Methylnitrosourea	[Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein	25164625
D008770	Methylnitrosourea	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein]	25164625
C008493	methylselenic acid	methylselenic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]	17339365
C008493	methylselenic acid	methylselenic acid results in decreased phosphorylation of GSK3B protein	17339365
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of GSK3B mRNA	29191790
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of GSK3B protein]	16882987
D008911	Minocycline	Minocycline results in increased phosphorylation of GSK3B protein	15569265
C010052	mizoribine	mizoribine inhibits the reaction [Puromycin Aminonucleoside results in increased phosphorylation of GSK3B protein]	20502051
C548887	MK 2206	MK 2206 inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of GSK3B protein]	29669060
C016599	mono-(2-ethylhexyl)phthalate	[mono-(2-ethylhexyl)phthalate results in decreased activity of INS protein] which results in decreased phosphorylation of GSK3B protein	31228551
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased phosphorylation of GSK3B protein	31228551
C016599	mono-(2-ethylhexyl)phthalate	RBP4 protein promotes the reaction [[mono-(2-ethylhexyl)phthalate results in decreased activity of INS protein] which results in decreased phosphorylation of GSK3B protein]	31228551
C016599	mono-(2-ethylhexyl)phthalate	RBP4 protein promotes the reaction [mono-(2-ethylhexyl)phthalate results in decreased phosphorylation of GSK3B protein]	31228551
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate inhibits the reaction [INS1 protein results in increased phosphorylation of GSK3B protein]	28526321
C008542	monodansylcadaverine	monodansylcadaverine results in decreased expression of GSK3B protein	16170020
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of GSK3B mRNA	26924002
C008548	morin	morin inhibits the reaction [Acetaminophen results in decreased phosphorylation of GSK3B protein]	26767949
C008548	morin	morin inhibits the reaction [Diethylnitrosamine results in increased expression of GSK3B protein modified form]	19931519
D009020	Morphine	Morphine results in increased expression of GSK3B protein modified form	20600172
D009020	Morphine	Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form]	20600172
D009020	Morphine	GSK3B protein results in decreased activity of Morphine	19966058
D009020	Morphine	Morphine results in increased phosphorylation of GSK3B protein	19966058
D009020	Morphine	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Morphine results in increased phosphorylation of GSK3B protein]	19966058
D009173	Mycophenolic Acid	Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GSK3B protein]	20302854
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Caffeine results in increased phosphorylation of GSK3B protein]	21229324
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]	21715663
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]	21715663
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]	21715663
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in decreased expression of CCNB1 protein]	20540935
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in decreased expression of CCND1 protein]	20540935
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in decreased expression of CCNE1 protein]	20540935
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in decreased expression of CDK2 protein]	20540935
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in decreased expression of CDK4 protein]	20540935
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in increased expression of BAX protein]	20540935
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in increased expression of CASP3 protein]	20540935
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in increased expression of CASP9 protein]	20540935
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] which results in decreased susceptibility to Okadaic Acid	21715663
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] which results in decreased susceptibility to Proadifen	22683934
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] which results in increased susceptibility to Troglitazone	20540935
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein	16202587
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein	20540935; 21715663; 22683934;
C064769	N-acetylsphingosine	GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]	21821001
C064769	N-acetylsphingosine	N-acetylsphingosine results in decreased phosphorylation of GSK3B protein	21821001
D009243	NAD	GSK3B protein mutant form results in increased abundance of NAD metabolite	25246272
D009249	NADP	GSK3B protein mutant form results in increased abundance of NADP metabolite	25246272
D009270	Naloxone	Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form]	20600172
D037742	Nanotubes, Carbon	Nanotubes, Carbon affects the expression of GSK3B mRNA	23845593
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of GSK3B mRNA	25554681
C000621033	napabucasin	napabucasin results in decreased expression of GSK3B mRNA	25605917
D009288	Naproxen	Naproxen results in decreased activity of GSK3B protein	23784744
C524653	nectandrin-B	nectandrin-B results in increased phosphorylation of GSK3B protein	27511913
C524653	nectandrin-B	GSK3B protein inhibits the reaction [nectandrin-B results in increased expression of GCLC mRNA]	27511913
C524653	nectandrin-B	GSK3B protein inhibits the reaction [nectandrin-B results in increased expression of GCLC protein]	27511913
D009355	Neomycin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Neomycin results in increased phosphorylation of GSK3B protein]	15800129
D009355	Neomycin	Neomycin results in increased phosphorylation of GSK3B protein	15800129
C022838	nickel chloride	nickel chloride promotes the reaction [Tretinoin results in increased phosphorylation of GSK3B protein]	25614230
C022838	nickel chloride	[nickel chloride results in increased phosphorylation of AKT1 protein] which results in decreased activity of and results in increased phosphorylation of GSK3B protein	21837363
C022838	nickel chloride	nickel chloride affects the expression of GSK3B mRNA	22546817
C029938	nickel sulfate	nickel sulfate results in increased expression of GSK3B mRNA	17374397
D009534	Niclosamide	Niclosamide results in decreased expression of GSK3B mRNA	22576131
D009538	Nicotine	[Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein	12511591
C012655	nimesulide	nimesulide results in decreased activity of GSK3B protein	16331303
D009583	Nitrofurazone	Nitrofurazone binds to GSK3B protein	18222664
D009599	Nitroprusside	Nitroprusside results in decreased phosphorylation of and results in increased activity of GSK3B protein	29353218
C562238	N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide	ILK protein inhibits the reaction [N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased phosphorylation of GSK3B protein]	21823616
C562238	N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide	N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased phosphorylation of GSK3B protein	21823616
D018817	N-Methyl-3,4-methylenedioxyamphetamine	N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GSK3B mRNA	19285098; 20188158;
D018817	N-Methyl-3,4-methylenedioxyamphetamine	N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GSK3B protein	19285098
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Morphine results in increased phosphorylation of GSK3B protein]	19966058
C072936	notoginsenoside R1	Fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]	23170834
C072936	notoginsenoside R1	notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]	23170834
C072936	notoginsenoside R1	Wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]	23170834
C072936	notoginsenoside R1	notoginsenoside R1 results in increased expression of GSK3B protein modified form	24720662
C404397	NSC 680410	NSC 680410 results in decreased phosphorylation of GSK3B protein	14647418
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of GSK3B mRNA	20971185
C025589	ochratoxin A	ochratoxin A results in increased phosphorylation of GSK3B protein	25002221
D019319	Okadaic Acid	[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]	21715663
D019319	Okadaic Acid	[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]	21715663
D019319	Okadaic Acid	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]	21715663
D019319	Okadaic Acid	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]	21715663
D019319	Okadaic Acid	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]	21715663
D019319	Okadaic Acid	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] which results in decreased susceptibility to Okadaic Acid	21715663
D019319	Okadaic Acid	Okadaic Acid inhibits the reaction [Resveratrol results in decreased phosphorylation of GSK3B protein]	23292070
D019319	Okadaic Acid	Okadaic Acid results in increased expression of GSK3B protein	21715663
D019319	Okadaic Acid	Okadaic Acid results in increased expression of GSK3B protein modified form	21715663
D019319	Okadaic Acid	[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]	21715663
D019319	Okadaic Acid	[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]	21715663
D019319	Okadaic Acid	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]]	27050422
D019319	Okadaic Acid	Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]	27050422
D019319	Okadaic Acid	Okadaic Acid affects the phosphorylation of GSK3B protein	27050422
D019319	Okadaic Acid	Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]	27050422
D000077152	Olanzapine	Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]	31563592
D000077152	Olanzapine	Olanzapine results in decreased expression of GSK3B mRNA	31563592
D000077152	Olanzapine	Olanzapine results in increased phosphorylation of GSK3B protein	19440698
D009942	Organometallic Compounds	Organometallic Compounds results in decreased activity of GSK3B protein	17210701
D000077150	Oxaliplatin	[Oxaliplatin co-treated with Topotecan] results in decreased expression of GSK3B mRNA	25729387
D010100	Oxygen	dictamnine inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]	30266538
D010100	Oxygen	Oxygen deficiency results in increased phosphorylation of GSK3B protein	30266538
D010100	Oxygen	cobaltiprotoporphyrin promotes the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]	24658657
D010100	Oxygen	GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of HMOX1 mRNA]]	29719095
D010100	Oxygen	GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NFE2L2 protein]]	29719095
D010100	Oxygen	GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NQO1 mRNA]]	29719095
D010100	Oxygen	GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]	29719095
D010100	Oxygen	MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B mRNA]	29719095
D010100	Oxygen	MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B protein]	29719095
D010100	Oxygen	[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased phosphorylation of GSK3B protein	24058562
D010100	Oxygen	[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of GSK3B protein	26116440
D010100	Oxygen	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B mRNA	29719095
D010100	Oxygen	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSK3B protein	29719095
D010100	Oxygen	Oxygen deficiency results in increased phosphorylation of GSK3B protein	24658657
D010100	Oxygen	sodium bisulfide inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased phosphorylation of GSK3B protein]	24058562
D010100	Oxygen	tin protoporphyrin IX inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]]	24658657
D019308	Palmitic Acid	Palmitic Acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	30362509
D000073878	Palm Oil	Palm Oil results in decreased expression of GSK3B mRNA	18042831
D010269	Paraquat	6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to GSK3B protein]]	28414160
D010269	Paraquat	6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of GSK3B protein modified form]	28414160
D010269	Paraquat	Paraquat inhibits the reaction [TNFRSF10B protein binds to GSK3B protein]	28414160
D010269	Paraquat	Paraquat results in decreased expression of GSK3B protein	28414160
D010269	Paraquat	Paraquat results in increased phosphorylation of GSK3B protein	30205152
D010269	Paraquat	WNT1 protein inhibits the reaction [Paraquat results in decreased phosphorylation of GSK3B protein]	30171970
D010269	Paraquat	Lithium Chloride inhibits the reaction [Paraquat results in decreased phosphorylation of GSK3B protein]	30171970
D010269	Paraquat	Paraquat results in decreased phosphorylation of GSK3B protein	30171970
D010269	Paraquat	Paraquat results in increased expression of and results in increased phosphorylation of GSK3B protein	22292029
D010269	Paraquat	Paraquat results in increased phosphorylation of GSK3B protein	24634145
D052638	Particulate Matter	Particulate Matter results in decreased expression of GSK3B mRNA	28412507
C522391	perfluorododecanoic acid	GSK3B protein affects the susceptibility to perfluorododecanoic acid	23353032
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of GSK3B protein	23353032
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of GSK3B protein modified form	23353032
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in increased expression of GSK3B protein modified form	22387981
C076994	perfluorooctane sulfonic acid	Lithium Chloride inhibits the reaction [perfluorooctane sulfonic acid results in decreased phosphorylation of GSK3B protein]	27018151
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased phosphorylation of GSK3B protein	27018151
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased phosphorylation of GSK3B protein	28947262
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of GSK3B mRNA	17097637
C058305	phenethyl isothiocyanate	Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased phosphorylation of GSK3B protein]	25246272
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased phosphorylation of GSK3B protein	25246272
D010634	Phenobarbital	Phenobarbital results in decreased expression of GSK3B mRNA	23091169
D010656	Phenylephrine	GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]	28759639
D010656	Phenylephrine	Phenylephrine results in increased phosphorylation of GSK3B protein	15795328; 28759639;
D010656	Phenylephrine	SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]	15795328
D010693	Phloretin	Phloretin results in decreased activity of GSK3B protein	16968061
D010696	Phloroglucinol	Phloroglucinol analog results in decreased phosphorylation of GSK3B protein	23178381
D010743	Phospholipids	Phospholipids results in increased phosphorylation of GSK3B protein	15956784
D064209	Phytochemicals	Phytochemicals results in decreased phosphorylation of GSK3B protein	22685690
D048789	Phytoestrogens	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phytoestrogens results in increased phosphorylation of GSK3B protein]	24726523
D048789	Phytoestrogens	Fulvestrant inhibits the reaction [Phytoestrogens results in increased phosphorylation of GSK3B protein]	24726523
D048789	Phytoestrogens	Phytoestrogens results in increased phosphorylation of GSK3B protein	24726523
C544307	PI 620	PI 620 results in decreased phosphorylation of GSK3B protein	19584227
C421173	plantamajoside	plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]	31009642
D010936	Plant Extracts	Plant Extracts results in decreased phosphorylation of GSK3B protein	22685690
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of GSK3B protein]	31586550
D010936	Plant Extracts	Plant Extracts results in decreased activity of GSK3B protein	24380755
D010936	Plant Extracts	Plant Extracts results in decreased phosphorylation of GSK3B protein	31306686
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Streptozocin results in increased expression of GSK3B mRNA]	27038876
C498513	PNU-282987	[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein]	21715663
C498513	PNU-282987	[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased expression of GSK3B protein modified form]	21715663
C498513	PNU-282987	[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in increased phosphorylation of GSK3B protein	21715663
D011078	Polychlorinated Biphenyls	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Polychlorinated Biphenyls analog results in decreased expression of GSK3B protein]	24361488
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in decreased expression of GSK3B protein	24361488
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased phosphorylation of GSK3B protein	31348943
D011188	Potassium	GW 506033X promotes the reaction [Potassium deficiency results in decreased phosphorylation of GSK3B protein]	19046382
D011188	Potassium	Potassium deficiency results in decreased phosphorylation of GSK3B protein	19046382
D011188	Potassium	Potassium results in increased phosphorylation of and results in decreased activity of GSK3B protein	15950778
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GSK3B mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of GSK3B mRNA	22079256
D011280	Pregnanolone	Pregnanolone results in decreased expression of GSK3B protein	17443805
D011335	Proadifen	GSK3B protein affects the susceptibility to Proadifen	22683934
D011335	Proadifen	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] which results in decreased susceptibility to Proadifen	22683934
C479580	procyanidin B2	procyanidin B2 inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]	21505870
C479580	procyanidin B2	procyanidin B2 results in increased expression of GSK3B protein modified form	21505870
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of GSK3B protein]	16882987
D011374	Progesterone	Progesterone results in increased phosphorylation of GSK3B protein	16882987
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]	15845746
D011374	Progesterone	Estradiol inhibits the reaction [Progesterone results in decreased expression of GSK3B mRNA]	17170212
D011374	Progesterone	Progesterone results in decreased expression of GSK3B mRNA	17170212
D011374	Progesterone	Progesterone results in decreased expression of GSK3B protein	17443805
D011374	Progesterone	Progesterone results in decreased phosphorylation of GSK3B protein	17443805
D015742	Propofol	Dexmedetomidine inhibits the reaction [Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein]	31187143
D015742	Propofol	Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein	31187143
D011433	Propranolol	Propranolol results in decreased phosphorylation of GSK3B protein	22982863
C107773	pterostilbene	pterostilbene inhibits the reaction [Azoxymethane results in increased phosphorylation of GSK3B protein]	20681671
D011692	Puromycin Aminonucleoside	mizoribine inhibits the reaction [Puromycin Aminonucleoside results in increased phosphorylation of GSK3B protein]	20502051
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased phosphorylation of GSK3B protein	20502051
C014175	pyrazolo(3,4-d)pyrimidine	pyrazolo(3,4-d)pyrimidine analog affects the expression of GSK3B mRNA	21152443
C008704	pyrithione	AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein]	17098228
C008704	pyrithione	GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein]	17098228
C008704	pyrithione	[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein	17098228
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid results in increased phosphorylation of GSK3B protein	17409235
D011794	Quercetin	Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of GSK3B protein]	25380086
D011794	Quercetin	Quercetin results in decreased activity of GSK3B protein	16968061
D011794	Quercetin	Quercetin results in decreased expression of GSK3B mRNA	23727915
D011794	Quercetin	Quercetin results in decreased expression of GSK3B protein	16968065
D011794	Quercetin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]]	27050422
D011794	Quercetin	Quercetin inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]	27260466
D011794	Quercetin	Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]	27050422
D011794	Quercetin	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein]	25164625
D011794	Quercetin	Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein]	23117658
D011796	Quinacrine	GSK3B protein affects the reaction [Quinacrine results in decreased expression of CCND1 protein]	28720477
D011796	Quinacrine	GSK3B protein affects the reaction [Quinacrine results in decreased expression of CTNNB1 protein]	28720477
D011796	Quinacrine	GSK3B protein affects the reaction [Quinacrine results in decreased expression of GLI1 protein]	28720477
D011796	Quinacrine	GSK3B protein affects the reaction [Quinacrine results in decreased expression of MYC protein]	28720477
D011796	Quinacrine	GSK3B protein affects the reaction [Quinacrine results in increased activity of CASP3 protein]	28720477
D011796	Quinacrine	GSK3B protein affects the reaction [Quinacrine results in increased expression of CSNK1A1 protein]	28720477
D011796	Quinacrine	Quinacrine results in increased expression of and results in decreased phosphorylation of GSK3B protein	28720477
D011796	Quinacrine	Quinacrine results in increased expression of GSK3B mRNA	28720477
C502851	quinocetone	Lithium Chloride promotes the reaction [quinocetone affects the phosphorylation of and results in decreased activity of GSK3B protein]	28343033
C502851	quinocetone	quinocetone affects the phosphorylation of and results in decreased activity of GSK3B protein	28343033
D011887	Raffinose	Raffinose results in increased phosphorylation of GSK3B protein	29458019
C052785	rebamipide	rebamipide results in increased expression of GSK3B mRNA	18299717
D000077185	Resveratrol	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein]	20696143
D000077185	Resveratrol	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein]	20696143
D000077185	Resveratrol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein]	20696143
D000077185	Resveratrol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of GSK3B protein]	14750165
D000077185	Resveratrol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein]	20696143
D000077185	Resveratrol	ARRB2 protein affects the reaction [Resveratrol results in decreased expression of GSK3B protein modified form]	20457218
D000077185	Resveratrol	dorsomorphin inhibits the reaction [Resveratrol results in decreased activity of GSK3B protein]	19620254
D000077185	Resveratrol	dorsomorphin inhibits the reaction [Resveratrol results in increased phosphorylation of GSK3B protein]	19620254
D000077185	Resveratrol	GSK3B protein affects the reaction [Resveratrol results in increased expression of FTH1 mRNA]	23829535
D000077185	Resveratrol	Okadaic Acid inhibits the reaction [Resveratrol results in decreased phosphorylation of GSK3B protein]	23292070
D000077185	Resveratrol	Resveratrol affects the expression of GSK3B protein modified form	22234583
D000077185	Resveratrol	Resveratrol inhibits the reaction [Excitatory Amino Acid Agonists affects the phosphorylation of GSK3B protein]	24675465
D000077185	Resveratrol	Resveratrol inhibits the reaction [GSK3B protein binds to SIRT1 protein]	23292070
D000077185	Resveratrol	Resveratrol inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]	21505870
D000077185	Resveratrol	Resveratrol results in decreased activity of GSK3B protein	19620254
D000077185	Resveratrol	Resveratrol results in decreased expression of GSK3B protein modified form	20133117; 20457218;
D000077185	Resveratrol	Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein	20696143
D000077185	Resveratrol	[Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased phosphorylation of and results in decreased localization of CTNNB1 protein	20696143
D000077185	Resveratrol	Resveratrol results in decreased phosphorylation of GSK3B protein	14750165; 20090934; 23292070; 26530632;
D000077185	Resveratrol	[Resveratrol results in decreased phosphorylation of GSK3B protein] which results in decreased expression of HSF1 mRNA	20090934
D000077185	Resveratrol	[Resveratrol results in decreased phosphorylation of GSK3B protein] which results in decreased expression of HSPA1A protein	20090934
D000077185	Resveratrol	Resveratrol results in increased activity of GSK3B protein	17868649; 20090934;
D000077185	Resveratrol	[Resveratrol results in increased activity of GSK3B protein] which results in decreased expression of HSF1 mRNA	20090934
D000077185	Resveratrol	Resveratrol results in increased expression of GSK3B protein modified form	21505870
D000077185	Resveratrol	Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein	20696143
D000077185	Resveratrol	[Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein] which results in decreased phosphorylation of and results in increased localization of CTNNB1 protein	20696143
D000077185	Resveratrol	Resveratrol results in increased phosphorylation of GSK3B protein	14750165; 19620254; 23829535;
D000077185	Resveratrol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in decreased activity of GSK3B protein]	20542495
D000077185	Resveratrol	dorsomorphin inhibits the reaction [[Resveratrol results in increased phosphorylation of GSK3B protein] which results in increased uptake of Glucose]	22180358
D000077185	Resveratrol	Resveratrol affects the phosphorylation of GSK3B protein	24254769
D000077185	Resveratrol	[Resveratrol co-treated with Excitatory Amino Acid Agents] results in increased phosphorylation of and results in decreased activity of GSK3B protein	20542495
D000077185	Resveratrol	Resveratrol inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]	24812660; 27260466;
D000077185	Resveratrol	Resveratrol results in decreased activity of GSK3B protein	19665018
D000077185	Resveratrol	Resveratrol results in decreased expression of GSK3B protein	19665018
D000077185	Resveratrol	Resveratrol results in increased phosphorylation of and results in decreased activity of GSK3B protein	20542495
D000077185	Resveratrol	Resveratrol results in increased phosphorylation of GSK3B protein	19665018; 22180358; 23129026;
D000077185	Resveratrol	[Resveratrol results in increased phosphorylation of GSK3B protein] which results in increased uptake of Glucose	22180358
D000077185	Resveratrol	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased activity of GSK3B protein]	19135050
D000077185	Resveratrol	Resveratrol inhibits the reaction [APP protein modified form results in decreased expression of GSK3B protein modified form]	25654502
D000077185	Resveratrol	Resveratrol results in decreased phosphorylation of GSK3B protein	24675465
D000077185	Resveratrol	[Resveratrol results in increased activity of GSK3B protein] which results in increased phosphorylation of VASP protein	19135050
D000077185	Resveratrol	Resveratrol results in increased phosphorylation of and results in decreased activity of GSK3B protein	16860989
D000077185	Resveratrol	Resveratrol results in increased phosphorylation of and results in increased localization of and results in increased activity of GSK3B protein	19135050
D000077185	Resveratrol	Resveratrol results in increased phosphorylation of GSK3B protein	22857612
D012256	Riboflavin	Riboflavin analog results in increased phosphorylation of GSK3B protein	20688149
D012256	Riboflavin	Riboflavin results in increased phosphorylation of GSK3B protein	20688149
D018967	Risperidone	DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein]	16144542
D018967	Risperidone	Risperidone results in increased expression of GSK3B protein	16144542
C064758	Ro 31-8220	Ro 31-8220 results in decreased activity of GSK3B protein	10998351
D000077154	Rosiglitazone	Rosiglitazone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	30362509
D000077154	Rosiglitazone	Rosiglitazone results in increased phosphorylation of GSK3B protein	25796170
D000077154	Rosiglitazone	Rosiglitazone inhibits the reaction [Methamphetamine results in increased phosphorylation of GSK3B protein]	29981415
D000077154	Rosiglitazone	Rosiglitazone results in decreased activity of GSK3B protein	19621015
D000077154	Rosiglitazone	Rosiglitazone results in decreased phosphorylation of GSK3B protein	29981415
D000077154	Rosiglitazone	Rosiglitazone results in increased phosphorylation of GSK3B protein	19566839
D000077154	Rosiglitazone	Wortmannin inhibits the reaction [Rosiglitazone results in increased phosphorylation of GSK3B protein]	19566839
D000077154	Rosiglitazone	GSK3B affects the reaction [Rosiglitazone inhibits the reaction [TNF protein results in increased activity of MMP9 protein]]	19201691
D000077154	Rosiglitazone	GSK3B protein mutant form affects the reaction [Rosiglitazone inhibits the reaction [TNF protein affects the localization of RELA protein]]	19201691
D000077154	Rosiglitazone	Rosiglitazone affects the reaction [PDGFB protein results in increased phosphorylation of GSK3B protein]	19201691
D012402	Rotenone	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]]	28245986
D012402	Rotenone	Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]	28245986
D012402	Rotenone	PARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]]	28245986
D012402	Rotenone	Rotenone results in decreased phosphorylation of GSK3B protein	28245986
D012402	Rotenone	Rotenone affects the expression of GSK3B mRNA	23186747
D012402	Rotenone	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]	25433145
D012402	Rotenone	Rotenone results in decreased phosphorylation of GSK3B protein	25433145; 28245986;
C085746	rottlerin	[Cadmium co-treated with rottlerin] results in decreased expression of GSK3B protein	27658547
C085746	rottlerin	rottlerin inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]	27658547
C085746	rottlerin	rottlerin results in decreased expression of GSK3B protein	27658547
C046245	rubimaillin	rubimaillin results in increased phosphorylation of GSK3B protein	23466342
D012428	Ruthenium	Ruthenium results in decreased activity of GSK3B protein	17210701
D017975	Ruthenium Compounds	Ruthenium Compounds results in decreased activity of GSK3B protein	16858717; 17210701;
C025759	saikosaponin	saikosaponin affects the phosphorylation of and results in increased activity of GSK3B protein	31175886
C025759	saikosaponin	SB 216763 inhibits the reaction [saikosaponin affects the phosphorylation of and results in increased activity of GSK3B protein]	31175886
C010327	salinomycin	salinomycin results in decreased expression of GSK3B mRNA	19682730
C036617	salsolinol	salsolinol results in decreased phosphorylation of GSK3B protein	23261589
C093642	SB 203580	SB 203580 inhibits the reaction [DEFA1 protein results in increased phosphorylation of GSK3B protein]	19814765
C093642	SB 203580	SB 203580 inhibits the reaction [DEFA2 protein results in increased phosphorylation of GSK3B protein]	19814765
C093642	SB 203580	SB 203580 results in decreased activity of GSK3B protein	10998351
C417521	SB 216763	SB 216763 results in decreased activity of GSK3B protein	19486905
C417521	SB 216763	PIK3CA protein affects the reaction [SB 216763 results in increased phosphorylation of and results in decreased activity of GSK3B protein]	19196980
C417521	SB 216763	SB 216763 inhibits the reaction [cinobufagin results in increased expression of GSK3B protein modified form]	23164673
C417521	SB 216763	SB 216763 results in decreased activity of GSK3B protein	19823589
C417521	SB 216763	[SB 216763 results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]	15753396
C417521	SB 216763	[SB 216763 results in decreased activity of GSK3B protein] results in decreased susceptibility to [Arachidonic Acid co-treated with Iron]	19620254
C417521	SB 216763	[SB 216763 results in decreased activity of GSK3B protein] which results in increased expression of HSPA1A protein alternative form	20090934
C417521	SB 216763	SB 216763 results in decreased phosphorylation of and results in decreased activity of GSK3B protein	21980429
C417521	SB 216763	SB 216763 results in decreased phosphorylation of GSK3B protein	16170020
C417521	SB 216763	SB 216763 results in increased expression of and results in increased phosphorylation of and results in decreased activity of GSK3B protein	19196980
C417521	SB 216763	SB 216763 inhibits the reaction [saikosaponin affects the phosphorylation of and results in increased activity of GSK3B protein]	31175886
C417521	SB 216763	SB 216763 results in decreased activity of GSK3B protein	19159680
C417521	SB 216763	[SB 216763 results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein	19159680
C417521	SB 216763	SB 216763 results in decreased phosphorylation of GSK3B protein	19448134
C417521	SB 216763	SB 216763 inhibits the reaction [Excitatory Amino Acid Agonists affects the phosphorylation of GSK3B protein]	24675465
C417521	SB 216763	SB 216763 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein]	30597158
C417521	SB 216763	SB 216763 results in decreased activity of GSK3B protein	16288908
C417521	SB 216763	SB 216763 binds to and results in decreased activity of GSK3B protein	15958644
C417521	SB 216763	SB 216763 results in decreased activity of GSK3B protein	15979805; 17210701; 17250809; 17339365; 19228266; 19620254; 20090934; 20190034; 20600172; 21711903; 23164673;
C406525	SB 239063	[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of GSK3B protein	26116440
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of GSK3B mRNA	19244175
D012643	Selenium	Selenium inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]	17339365
D012643	Selenium	Selenium results in decreased expression of GSK3B mRNA	19244175
D012643	Selenium	Selenium results in decreased phosphorylation of GSK3B protein	17339365
D012701	Serotonin	Serotonin results in increased phosphorylation of GSK3B protein	20190034
D012715	Sesame Oil	Sesame Oil results in increased expression of GSK3B mRNA	29191790
D012717	Sesquiterpenes	Sesquiterpenes analog results in increased phosphorylation of and results in decreased activity of GSK3B protein	30672058
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
C042431	S-ethyl glutathione	S-ethyl glutathione results in increased phosphorylation of GSK3B protein	25246272
D000077149	Sevoflurane	Lithium Chloride inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein]	20807582
D000077149	Sevoflurane	Sevoflurane results in decreased phosphorylation of GSK3B protein	20807582
C040115	shogaol	shogaol results in increased expression of and results in increased phosphorylation of GSK3B protein	27645308
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased phosphorylation of GSK3B protein	24831964
D012834	Silver	Silver results in increased expression of GSK3B mRNA	29283201
D012834	Silver	Silver affects the phosphorylation of GSK3B protein	27593553
D019821	Simvastatin	Simvastatin results in increased expression of GSK3B	19461118
D019821	Simvastatin	Simvastatin inhibits the reaction [Glucose results in decreased phosphorylation of and results in increased activity of GSK3B protein]	18004065
D019821	Simvastatin	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of GSK3B protein]	18047562
D019821	Simvastatin	Simvastatin results in increased expression of GSK3B protein modified form	18004065
D020123	Sirolimus	[Sirolimus results in decreased activity of MTOR protein] which results in increased phosphorylation of GSK3B protein	17908691
D020123	Sirolimus	[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]	15753396
D020123	Sirolimus	[Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]	15753396
D020123	Sirolimus	[SB 216763 results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]	15753396
D020123	Sirolimus	Sirolimus results in increased activity of GSK3B protein	15753396
D020123	Sirolimus	[Sirolimus results in increased activity of GSK3B protein] which results in increased phosphorylation of and results in increased degradation of CCND1 protein	15753396
D020123	Sirolimus	Sirolimus inhibits the reaction [TSC1 gene mutant form results in decreased phosphorylation of GSK3B protein]	18495876
C009277	sodium arsenate	sodium arsenate results in decreased expression of GSK3B mRNA	21795629
C009277	sodium arsenate	sodium arsenate results in increased expression of GSK3B mRNA	21795629
C017947	sodium arsenite	sodium arsenite affects the expression of GSK3B mRNA	22058191
C017947	sodium arsenite	[Ethanol co-treated with sodium arsenite] results in increased phosphorylation of GSK3B protein	26220687
C017947	sodium arsenite	Lithium promotes the reaction [sodium arsenite results in increased phosphorylation of GSK3B protein]	17849503
C017947	sodium arsenite	[sodium arsenite co-treated with Ethanol] results in increased phosphorylation of GSK3B protein	22872060
C017947	sodium arsenite	sodium arsenite inhibits the reaction [INS protein results in increased phosphorylation of GSK3B protein]	29526746
C017947	sodium arsenite	sodium arsenite promotes the reaction [IRS1 protein binds to GSK3B protein]	29526746
C017947	sodium arsenite	sodium arsenite results in decreased expression of GSK3B protein	29107899
C017947	sodium arsenite	sodium arsenite results in decreased phosphorylation of GSK3B protein	20043101
C017947	sodium arsenite	sodium arsenite results in increased expression of GSK3B protein modified form	16054901
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of and results in increased activity of GSK3B protein	12614848
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of GSK3B protein	17849503; 22859221; 26220687;
C017947	sodium arsenite	Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of GSK3B protein]	12614848
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of GSK3B protein	12529330
C017947	sodium arsenite	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]	29723552
C017947	sodium arsenite	Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]	27966075; 29723552;
C017947	sodium arsenite	sodium arsenite results in decreased phosphorylation of GSK3B protein	27966075; 29723552;
C016104	sodium bichromate	sodium bichromate results in decreased expression of GSK3B mRNA	22155349
C025451	sodium bisulfide	sodium bisulfide inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased phosphorylation of GSK3B protein]	24058562
D012969	Sodium Fluoride	DKK1 protein inhibits the reaction [Sodium Fluoride results in increased phosphorylation of GSK3B protein]	24300170
D012969	Sodium Fluoride	Sodium Fluoride results in increased phosphorylation of GSK3B protein	24300170
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of GSK3B mRNA	18175754
D000077157	Sorafenib	Arsenic Trioxide inhibits the reaction [Sorafenib results in increased phosphorylation of GSK3B protein]	25416439
D000077157	Sorafenib	GSK3B inhibits the reaction [Sorafenib affects the localization of AIFM1 protein]	17991738
D000077157	Sorafenib	GSK3B inhibits the reaction [Sorafenib affects the localization of DIABLO protein]	17991738
D000077157	Sorafenib	Sorafenib inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GSK3B protein]	25416439
D000077157	Sorafenib	Sorafenib promotes the reaction [GSK3B protein results in increased phosphorylation of MYC protein]	17991738
D000077157	Sorafenib	Sorafenib promotes the reaction [GSK3B protein results in increased phosphorylation of TP53 protein]	17991738
D000077157	Sorafenib	Sorafenib results in decreased phosphorylation of and results in increased activity of GSK3B protein	17991738
D000077157	Sorafenib	Sorafenib results in increased phosphorylation of GSK3B protein	25416439
D013311	Streptozocin	Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]	25541178
D013311	Streptozocin	Plant Extracts inhibits the reaction [Streptozocin results in increased expression of GSK3B mRNA]	27038876
D013311	Streptozocin	Streptozocin results in decreased phosphorylation of GSK3B protein	25541178
D013311	Streptozocin	Streptozocin results in increased expression of GSK3B mRNA	27038876
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of GSK3B mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] affects the expression of GSK3B mRNA	26378955
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein]	26165751
C016766	sulforafan	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforafan results in increased phosphorylation of and results in decreased activity of GSK3B protein]	29353218
C016766	sulforafan	sulforafan results in increased phosphorylation of and results in decreased activity of GSK3B protein	29353218
D013467	Sulindac	Sulindac results in decreased phosphorylation of GSK3B protein	11593435
C001945	syringic acid	syringic acid inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of and results in decreased phosphorylation of GSK3B protein]	31586550
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of GSK3B mRNA	26141394
D016559	Tacrolimus	[GSK3A protein co-treated with GSK3B protein] affects the reaction [Tacrolimus results in increased expression of SNAI1 protein]	22416070
D016559	Tacrolimus	Tacrolimus results in increased phosphorylation of GSK3B protein	22416070
D000068581	Tadalafil	Tadalafil inhibits the reaction [Thioacetamide results in decreased phosphorylation of GSK3B protein]	31323263
C061133	tamibarotene	tamibarotene affects the expression of GSK3B mRNA	15498508
D013629	Tamoxifen	Tamoxifen promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein]	22046442
D013629	Tamoxifen	Tamoxifen results in decreased phosphorylation of and results in increased expression of GSK3B protein	23921149
C112765	tanespimycin	tanespimycin results in decreased expression of GSK3B protein modified form	20090934
C021751	tanshinone	tanshinone results in decreased expression of GSK3B mRNA	25186638
D013654	Taurine	Taurine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	30362509
D013655	Taurochenodeoxycholic Acid	Taurochenodeoxycholic Acid results in increased phosphorylation of and results in decreased activity of GSK3B protein	20512997
D020122	tert-Butylhydroperoxide	3,4-dihydroxyphenyllactic acid inhibits the reaction [tert-Butylhydroperoxide results in decreased phosphorylation of GSK3B protein]	29128606
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased phosphorylation of GSK3B protein	29128606
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GSK3B mRNA	15336504
D013739	Testosterone	Testosterone results in increased expression of GSK3B mRNA	21880219
D013739	Testosterone	Testosterone results in increased expression of GSK3B mRNA	20843997
D013739	Testosterone	[Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein	25164625
D013739	Testosterone	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein]	25164625
C004648	testosterone enanthate	testosterone enanthate affects the expression of GSK3B mRNA	17440010
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of GSK3B mRNA	27914987
D013749	Tetrachlorodibenzodioxin	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GSK3B mRNA]	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GSK3B mRNA	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased phosphorylation of GSK3B protein	27312872
D013749	Tetrachlorodibenzodioxin	AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSK3B mRNA]	15034205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GSK3B mRNA	15034205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased phosphorylation of GSK3B protein	18996433
D013749	Tetrachlorodibenzodioxin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of GSK3B protein]	24231000
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased phosphorylation of GSK3B protein	23639626
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased phosphorylation of GSK3B protein	24231000
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased phosphorylation of GSK3B protein	17993264
D013755	Tetradecanoylphorbol Acetate	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GSK3B protein]	17993264
C050950	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Ethanol results in increased phosphorylation of GSK3B protein]	28962519
C009438	tetrandrine	tetrandrine results in decreased expression of GSK3B protein modified form	25266202
D013792	Thalidomide	Thalidomide results in increased expression of GSK3B mRNA	19751816
D013853	Thioacetamide	Tadalafil inhibits the reaction [Thioacetamide results in decreased phosphorylation of GSK3B protein]	31323263
D013853	Thioacetamide	Thioacetamide results in decreased phosphorylation of GSK3B protein	31323263
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]	27260466
D008063	Thioctic Acid	Thioctic Acid results in increased phosphorylation of GSK3B protein	19879292
D013882	Thiosemicarbazones	[Copper binds to Thiosemicarbazones analog] which results in decreased activity of GSK3B protein	19122148
D013882	Thiosemicarbazones	[Thiosemicarbazones binds to Copper] which results in increased expression of GSK3B protein	20931265
D013893	Thiram	Thiram results in decreased expression of GSK3B mRNA	20530235
C032628	tin protoporphyrin IX	tin protoporphyrin IX inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]]	24658657
C016151	tinuvin	tinuvin analog results in increased expression of GSK3B mRNA	30315675
D014028	Tobacco Smoke Pollution	GSK3B protein inhibits the reaction [Tobacco Smoke Pollution results in increased activity of [CTNNB1 protein binds to TCF4 protein]]	19429245
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of GSK3B protein	19429245
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased phosphorylation of and results in decreased activity of GSK3B protein	19429245
D014051	Toluene 2,4-Diisocyanate	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]	30517707
D014051	Toluene 2,4-Diisocyanate	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]	26089345
D014051	Toluene 2,4-Diisocyanate	GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]	30517707
D014051	Toluene 2,4-Diisocyanate	Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein	26089345; 30517707;
D000077236	Topiramate	Topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein]	29753867
D019772	Topotecan	[Oxaliplatin co-treated with Topotecan] results in decreased expression of GSK3B mRNA	25729387
D014118	Toxins, Biological	Toxins, Biological affects the expression of GSK3B mRNA	19682533
D014212	Tretinoin	Tretinoin results in increased expression of GSK3B mRNA	20530235
D014212	Tretinoin	nickel chloride promotes the reaction [Tretinoin results in increased phosphorylation of GSK3B protein]	25614230
D014212	Tretinoin	Tretinoin affects the expression of GSK3B mRNA	15498508
D014212	Tretinoin	Tretinoin results in increased phosphorylation of GSK3B protein	25614230
D014212	Tretinoin	Tretinoin results in decreased phosphorylation of GSK3B protein	16288212
D014212	Tretinoin	Tretinoin results in increased phosphorylation of GSK3B protein	16288212
D014302	Trinitrobenzenesulfonic Acid	geraniol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein]	26165751
D014302	Trinitrobenzenesulfonic Acid	Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein]	26165751
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein	26165751
D000077288	Troglitazone	GSK3B protein affects the susceptibility to Troglitazone	20540935
D000077288	Troglitazone	GSK3B protein affects the susceptibility to [Troglitazone results in decreased expression of CCNB1 protein]	20540935
D000077288	Troglitazone	GSK3B protein affects the susceptibility to [Troglitazone results in decreased expression of CCND1 protein]	20540935
D000077288	Troglitazone	GSK3B protein affects the susceptibility to [Troglitazone results in decreased expression of CCNE1 protein]	20540935
D000077288	Troglitazone	GSK3B protein affects the susceptibility to [Troglitazone results in decreased expression of CDK2 protein]	20540935
D000077288	Troglitazone	GSK3B protein affects the susceptibility to [Troglitazone results in decreased expression of CDK4 protein]	20540935
D000077288	Troglitazone	GSK3B protein affects the susceptibility to [Troglitazone results in increased expression of BAX protein]	20540935
D000077288	Troglitazone	GSK3B protein affects the susceptibility to [Troglitazone results in increased expression of CASP3 protein]	20540935
D000077288	Troglitazone	GSK3B protein affects the susceptibility to [Troglitazone results in increased expression of CASP9 protein]	20540935
D000077288	Troglitazone	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in decreased expression of CCNB1 protein]	20540935
D000077288	Troglitazone	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in decreased expression of CCND1 protein]	20540935
D000077288	Troglitazone	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in decreased expression of CCNE1 protein]	20540935
D000077288	Troglitazone	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in decreased expression of CDK2 protein]	20540935
D000077288	Troglitazone	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in decreased expression of CDK4 protein]	20540935
D000077288	Troglitazone	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in increased expression of BAX protein]	20540935
D000077288	Troglitazone	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in increased expression of CASP3 protein]	20540935
D000077288	Troglitazone	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [Troglitazone results in increased expression of CASP9 protein]	20540935
D000077288	Troglitazone	[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] which results in increased susceptibility to Troglitazone	20540935
D000077288	Troglitazone	Troglitazone results in decreased activity of GSK3B protein	20540935
D014414	Tungsten	Tungsten results in decreased expression of GSK3B mRNA	30912803
C547688	TWS 119	TWS 119 inhibits the reaction [Methamphetamine results in increased phosphorylation of GSK3B protein]	29981415
C547688	TWS 119	TWS 119 results in decreased phosphorylation of GSK3B protein	29981415
C113580	U 0126	U 0126 inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]	21278055
C113580	U 0126	U 0126 inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]	25246272
C113580	U 0126	U 0126 inhibits the reaction [EDN1 protein results in increased phosphorylation of GSK3B protein]	17993264
C113580	U 0126	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GSK3B protein]	17993264
D014520	Urethane	Urethane results in increased expression of GSK3B mRNA	28818685
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSK3B mRNA	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of GSK3B mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased activity of GSK3B protein	19101580
D014635	Valproic Acid	Valproic Acid results in decreased expression of GSK3B mRNA	26272509
D014635	Valproic Acid	Valproic Acid results in increased phosphorylation of and results in decreased activity of GSK3B protein	19328817
D014635	Valproic Acid	Valproic Acid results in increased phosphorylation of GSK3B protein	19440698
D014635	Valproic Acid	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]]	25453207
D014635	Valproic Acid	Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]	25453207
D014635	Valproic Acid	Valproic Acid results in increased expression of GSK3B mRNA	31445079
D014635	Valproic Acid	Valproic Acid results in decreased expression of GSK3B mRNA	19359144
D000068756	Valsartan	Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]	31009642
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GSK3B gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of GSK3B mRNA	19015723
D014752	Vinyl Chloride	Vinyl Chloride metabolite results in increased expression of GSK3B mRNA	26962056
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of GSK3B mRNA	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of GSK3B mRNA	19244175
D014810	Vitamin E	Vitamin E inhibits the reaction [Wortmannin results in decreased expression of GSK3B protein modified form]	15842767
D014812	Vitamin K	Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein]	23117658
D014812	Vitamin K	[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein	23117658
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of GSK3B protein	31238027
D014859	Warfarin	Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein]	23117658
D014859	Warfarin	[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein	23117658
D014873	Water Pollutants	Water Pollutants results in decreased expression of GSK3B mRNA	29777831
C085514	wogonin	wogonin results in decreased expression of GSK3B protein modified form	23872260
C085514	wogonin	wogonin results in increased expression of GSK3B protein	23872260
D000077191	Wortmannin	Wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]	16076840
D000077191	Wortmannin	Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]	31173752
D000077191	Wortmannin	Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of GSK3B protein]	12614848
D000077191	Wortmannin	Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein]	17513037
D000077191	Wortmannin	Wortmannin results in decreased phosphorylation of GSK3B protein	20090934; 23178381;
D000077191	Wortmannin	Melatonin inhibits the reaction [Wortmannin results in decreased expression of GSK3B protein modified form]	15842767
D000077191	Wortmannin	Vitamin E inhibits the reaction [Wortmannin results in decreased expression of GSK3B protein modified form]	15842767
D000077191	Wortmannin	Wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]	23170834
D000077191	Wortmannin	Wortmannin results in decreased expression of GSK3B protein modified form	15842767
D000077191	Wortmannin	Wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]	18040759
D000077191	Wortmannin	Wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of GSK3B protein]	28759639
D000077191	Wortmannin	Wortmannin inhibits the reaction [Rosiglitazone results in increased phosphorylation of GSK3B protein]	19566839
D015032	Zinc	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein]	17513037
D015032	Zinc	Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein]	17513037
D015032	Zinc	Zinc results in increased phosphorylation of GSK3B protein	17513037
D015032	Zinc	AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein]	17098228
D015032	Zinc	GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein]	17098228
D015032	Zinc	[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein	17098228
D015032	Zinc	Zinc deficiency results in decreased phosphorylation of GSK3B protein	21893222

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0013	ADP-ribosylation
KW-0025	Alternative splicing
KW-0026	Alzheimer disease
KW-0067	ATP-binding
KW-0090	Biological rhythms
KW-0119	Carbohydrate metabolism
KW-1003	Cell membrane
KW-0963	Cytoplasm
KW-0217	Developmental protein
KW-0219	Diabetes mellitus
KW-0221	Differentiation
KW-0321	Glycogen metabolism
KW-0418	Kinase
KW-0472	Membrane
KW-0524	Neurogenesis
KW-0547	Nucleotide-binding
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0723	Serine/threonine-protein kinase
KW-0734	Signal transduction inhibitor
KW-0808	Transferase
KW-0879	Wnt signaling pathway

Interpro

InterPro ID	InterPro Term
IPR033573	GSK3B
IPR011009	Kinase-like_dom_sf
IPR000719	Prot_kinase_dom
IPR017441	Protein_kinase_ATP_BS
IPR008271	Ser/Thr_kinase_AS
IPR039192	STKc_GSK3

PROSITE

PROSITE ID	PROSITE Term
PS00107	PROTEIN_KINASE_ATP
PS50011	PROTEIN_KINASE_DOM
PS00108	PROTEIN_KINASE_ST

Pfam

Pfam ID	Pfam Term
PF00069	Pkinase

Gene: GSK3B

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction