| Tag | Content |
|---|---|
| Uniprot ID | P49918 |
| Entrez ID | 1028 |
| Genbank protein ID | BAA11015.1; AAH67842.1; AAB05896.1; BAA11014.1; AAA85095.1; |
| Genbank nucleotide ID | XM_017017088.1; NM_001122630.1; NM_001122631.1; NM_000076.2; |
| Ensembl protein ID | ENSP00000411257; ENSP00000411552; ENSP00000413720; |
| Ensembl nucleotide ID | ENSG00000129757 |
| Gene name | Cyclin-dependent kinase inhibitor 1C |
| Gene symbol | CDKN1C |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. |
| Sequence | MSDASLRSTS TMERLVARGT FPVLVRTSAC RSLFGPVDHE ELSRELQARL AELNAEDQNR 60 WDYDFQQDMP LRGPGRLQWT EVDSDSVPAF YRETVQVGRC RLLLAPRPVA VAVAVSPPLE 120 PAAESLDGLE EAPEQLPSVP VPAPASTPPP VPVLAPAPAP APAPVAAPVA APVAVAVLAP 180 APAPAPAPAP APAPVAAPAP APAPAPAPAP APAPAPDAAP QESAEQGANQ GQRGQEPLAD 240 QLHSGISGRP AAGTAAASAN GAAIKKLSGP LISDFFAKRK RSAPEKSSGD VPAPCPSPSA 300 APGVGSVEQT PRKRLR 316 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.