| Tag | Content |
|---|---|
| Uniprot ID | P53712; Q0PDN7; Q29RM8; Q8SQC0; |
| Entrez ID | 281876 |
| Genbank protein ID | AAI14108.1; ABH07895.1; AAL78037.1; AAA80571.1; |
| Genbank nucleotide ID | XM_010811097.2; NM_174368.3; XM_005214148.3; |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Integrin beta-1 |
| Gene symbol | ITGB1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). |
| Sequence | MNLQLIFWIG LISSVCCVFG QADENRCLKA NAKSCGECIQ AGPNCGWCTN STFLQEGMPT 60 SARCDDLEAL KKKGCHPNDI ENPRGSKDIK KNKNVTNRSK GTAEKLQPED ITQIQPQQLV 120 LQLRSGEPQT FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF 180 RIGFGSFVEK TVMPYISTTP AKLRNPCTNE QNCTSPFSYK NVLSLTDKGE VFNELVGKQR 240 ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ 300 CHLENDVYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL 360 SANSSNVIQL IIDAYNSLSS EVILENSKLP EGVTINYKSY CKNGVNGTGE NGRKCSNISI 420 GDEVQFEISI TANKCPNKNS ETIKIKPLGF TEEVEIILQF ICECECQGEG IPGSPKCHDG 480 NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK 540 RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCKCRVCE CNPNYTGSAC DCSLDTTSCM 600 AVNGQICNGR GVCECGACKC TDPKFQGPTC EMCQTCLGVC AEHKECVQCR AFNKGEKKDT 660 CAQECSHFNI TKVENRDKLP QPGQVDPLSH CKEKDVDDCW FYFTYSVNGN NEATVHVVET 720 PECPTGPDII PIVAGVVAGI VLIGLALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTGEN 780 PIYKSAVTTV VNPKYEGK 798 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0005925 | focal adhesion |
| GO:0008305 | integrin complex |
| GO:0071438 | invadopodium membrane |
| GO:0030027 | lamellipodium |
| GO:0042470 | melanosome |
| GO:0016020 | membrane |
| GO:0055037 | recycling endosome |
| GO:0032587 | ruffle membrane |
| GO:0042383 | sarcolemma |
| GO:0098639 | collagen binding involved in cell-matrix adhesion |
| GO:0001968 | fibronectin binding |
| GO:0005178 | integrin binding |
| GO:0046872 | metal ion binding |
| GO:0046982 | protein heterodimerization activity |
| GO:0038023 | signaling receptor activity |
| GO:0001618 | virus receptor activity |
| GO:0033627 | cell adhesion mediated by integrin |
| GO:0016477 | cell migration |
| GO:0007160 | cell-matrix adhesion |
| GO:0071404 | cellular response to low-density lipoprotein particle stimulus |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0030335 | positive regulation of cell migration |
| GO:1903078 | positive regulation of protein localization to plasma membrane |
| GO:0031623 | receptor internalization |
| GO:0010710 | regulation of collagen catabolic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0025 | Alternative splicing |
| KW-0130 | Cell adhesion |
| KW-0965 | Cell junction |
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-1015 | Disulfide bond |
| KW-0967 | Endosome |
| KW-0325 | Glycoprotein |
| KW-1183 | Host cell receptor for virus entry |
| KW-0945 | Host-virus interaction |
| KW-0401 | Integrin |
| KW-1017 | Isopeptide bond |
| KW-0460 | Magnesium |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0832 | Ubl conjugation |
| InterPro ID | InterPro Term |
|---|---|
| IPR013111 | EGF_extracell |
| IPR040622 | I-EGF_1 |
| IPR027071 | Integrin_beta-1 |
| IPR033760 | Integrin_beta_N |
| IPR015812 | Integrin_bsu |
| IPR014836 | Integrin_bsu_cyt_dom |
| IPR012896 | Integrin_bsu_tail |
| IPR036349 | Integrin_bsu_tail_dom_sf |
| IPR002369 | Integrin_bsu_VWA |
| IPR032695 | Integrin_dom_sf |
| IPR016201 | PSI |
| IPR036465 | vWFA_dom_sf |