CleftGeneDB-Search

Gene: RAD23B

Basic information

Tag	Content
Uniprot ID	P54727; B3KWK8; G5E9P0; Q7Z5K8; Q8WUB0;
Entrez ID	5887
Genbank protein ID	AAH20973.1; AAP81008.1; BAG54170.1; EAW59016.1; EAW59017.1; AAN47194.1; BAA04652.1;
Genbank nucleotide ID	NM_002874.4; NM_001244724.1;
Ensembl protein ID	ENSP00000350708; ENSP00000405623;
Ensembl nucleotide ID	ENSG00000119318
Gene name	UV excision repair protein RAD23 homolog B
Gene symbol	RAD23B
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.
Sequence	MQVTLKTLQQ QTFKIDIDPE ETVKALKEKI ESEKGKDAFP VAGQKLIYAG KILNDDTALK 60 EYKIDEKNFV VVMVTKPKAV STPAPATTQQ SAPASTTAVT SSTTTTVAQA PTPVPALAPT 120 STPASITPAS ATASSEPAPA SAAKQEKPAE KPAETPVATS PTATDSTSGD SSRSNLFEDA 180 TSALVTGQSY ENMVTEIMSM GYEREQVIAA LRASFNNPDR AVEYLLMGIP GDRESQAVVD 240 PPQAASTGAP QSSAVAAAAA TTTATTTTTS SGGHPLEFLR NQPQFQQMRQ IIQQNPSLLP 300 ALLQQIGREN PQLLQQISQH QEHFIQMLNE PVQEAGGQGG GGGGGSGGIA EAGSGHMNYI 360 QVTPQEKEAI ERLKALGFPE GLVIQAYFAC EKNENLAANF LLQQNFDED 409

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1P1A
1PVE
1UEL
1P1A

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	RAD23B	530189	Q29RK4		Bos taurus	Prediction	More>>
1:1 ortholog	RAD23B	481656	E2R4A5		Canis lupus familiaris	Prediction	More>>
1:1 ortholog	RAD23B	102183790	A0A452FP98		Capra hircus	Prediction	More>>
1:1 ortholog	RAD23B	5887	P54727		Homo sapiens	Prediction	More>>
1:1 ortholog	Rad23b	19359	P54728	CPO	Mus musculus	Publication	More>>
1:1 ortholog	RAD23B	473012	K7BCM9		Pan troglodytes	Prediction	More>>
1:1 ortholog		100153668	A0A480DNV8		Sus scrofa	Prediction	More>>
1:1 ortholog	RAD23B	100353489	G1SST9		Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Rad23b	298012	Q4KMA2		Rattus norvegicus	Prediction	More>>
1:1 ortholog	rad23b	393536	A0A2R8PYT0		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs1182543787	p.Thr4Ile	missense variant	-	NC_000009.12:g.107283640C>T	gnomAD
rs758392805	p.Leu5Val	missense variant	-	NC_000009.12:g.107283642C>G	ExAC,TOPMed,gnomAD
rs1174873515	p.Thr7Asn	missense variant	-	NC_000009.12:g.107283649C>A	TOPMed,gnomAD
rs1174873515	p.Thr7Ile	missense variant	-	NC_000009.12:g.107283649C>T	TOPMed,gnomAD
rs1465390576	p.Leu8Val	missense variant	-	NC_000009.12:g.107283651C>G	gnomAD
rs1264249597	p.Gln11Arg	missense variant	-	NC_000009.12:g.107283661A>G	TOPMed
rs1329772380	p.Thr12Ile	missense variant	-	NC_000009.12:g.107283664C>T	gnomAD
rs755530025	p.Phe13Leu	missense variant	-	NC_000009.12:g.107283668C>A	ExAC,gnomAD
rs781683465	p.Lys14Met	missense variant	-	NC_000009.12:g.107283670A>T	ExAC,TOPMed,gnomAD
rs781683465	p.Lys14Arg	missense variant	-	NC_000009.12:g.107283670A>G	ExAC,TOPMed,gnomAD
rs781683465	p.Lys14Thr	missense variant	-	NC_000009.12:g.107283670A>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ile15Val	missense variant	-	NC_000009.12:g.107283672A>G	NCI-TCGA
rs1230946595	p.Asp16Asn	missense variant	-	NC_000009.12:g.107283675G>A	gnomAD
rs868532415	p.Asp16Glu	missense variant	-	NC_000009.12:g.107283677C>A	TOPMed,gnomAD
rs1264871577	p.Asp16Ala	missense variant	-	NC_000009.12:g.107283676A>C	gnomAD
rs748424653	p.Ile17Val	missense variant	-	NC_000009.12:g.107283678A>G	ExAC,gnomAD
rs1481733080	p.Asp18Gly	missense variant	-	NC_000009.12:g.107283682A>G	TOPMed,gnomAD
rs922886223	p.Glu20Lys	missense variant	-	NC_000009.12:g.107283687G>A	TOPMed,gnomAD
rs771718228	p.Lys24Arg	missense variant	-	NC_000009.12:g.107300145A>G	ExAC,gnomAD
rs1409602868	p.Glu33Gly	missense variant	-	NC_000009.12:g.107300172A>G	gnomAD
rs760729054	p.Lys34Arg	missense variant	-	NC_000009.12:g.107300175A>G	ExAC,gnomAD
COSM1103632	p.Lys36Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107300182A>C	NCI-TCGA Cosmic
rs1403843166	p.Asp37Gly	missense variant	-	NC_000009.12:g.107300184A>G	gnomAD
rs1244948800	p.Ala38Gly	missense variant	-	NC_000009.12:g.107300187C>G	TOPMed
rs768301757	p.Val41Leu	missense variant	-	NC_000009.12:g.107300195G>C	ExAC,gnomAD
NCI-TCGA novel	p.Lys45AsnPheSerTerUnk	frameshift	-	NC_000009.12:g.107300205A>-	NCI-TCGA
rs776541236	p.Tyr48Phe	missense variant	-	NC_000009.12:g.107300217A>T	ExAC,gnomAD
NCI-TCGA novel	p.Tyr48Cys	missense variant	-	NC_000009.12:g.107300217A>G	NCI-TCGA
NCI-TCGA novel	p.Ala49Thr	missense variant	-	NC_000009.12:g.107300219G>A	NCI-TCGA
rs781760113	p.Asn54Ser	missense variant	-	NC_000009.12:g.107302047A>G	ExAC,TOPMed,gnomAD
rs1389288527	p.Asn54His	missense variant	-	NC_000009.12:g.107302046A>C	gnomAD
rs201722512	p.Asp56Gly	missense variant	-	NC_000009.12:g.107302053A>G	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Thr57Ala	missense variant	-	NC_000009.12:g.107302055A>G	NCI-TCGA
rs1161721301	p.Ala58Pro	missense variant	-	NC_000009.12:g.107302058G>C	gnomAD
rs757678716	p.Leu59Val	missense variant	-	NC_000009.12:g.107302061C>G	ExAC,TOPMed,gnomAD
COSM1222994	p.Glu61Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000009.12:g.107302067G>T	NCI-TCGA Cosmic
rs765760139	p.Glu61Asp	missense variant	-	NC_000009.12:g.107302069A>T	ExAC,TOPMed,gnomAD
rs1298067283	p.Asp65Val	missense variant	-	NC_000009.12:g.107302080A>T	gnomAD
NCI-TCGA novel	p.Asn68ThrPheSerTerUnk	frameshift	-	NC_000009.12:g.107302085A>-	NCI-TCGA
rs1346689700	p.Val80Leu	missense variant	-	NC_000009.12:g.107306388G>T	TOPMed
rs376878974	p.Val80Gly	missense variant	-	NC_000009.12:g.107306389T>G	ESP,ExAC,TOPMed,gnomAD
rs765992287	p.Thr82Lys	missense variant	-	NC_000009.12:g.107306395C>A	ExAC,gnomAD
rs1348422706	p.Thr87Ala	missense variant	-	NC_000009.12:g.107306409A>G	TOPMed,gnomAD
rs754501431	p.Ser91Leu	missense variant	-	NC_000009.12:g.107306422C>T	ExAC,TOPMed,gnomAD
rs1441579574	p.Ala92Pro	missense variant	-	NC_000009.12:g.107306424G>C	gnomAD
rs1181533322	p.Ser95Asn	missense variant	-	NC_000009.12:g.107306434G>A	gnomAD
rs780635159	p.Thr96Ile	missense variant	-	NC_000009.12:g.107306437C>T	ExAC,gnomAD
NCI-TCGA novel	p.Ala98Ser	missense variant	-	NC_000009.12:g.107306442G>T	NCI-TCGA
rs79639067	p.Ser102Pro	missense variant	-	NC_000009.12:g.107306454T>C	ESP,ExAC,TOPMed
rs79639067	p.Ser102Ala	missense variant	-	NC_000009.12:g.107306454T>G	ESP,ExAC,TOPMed
rs749014621	p.Thr103Ile	missense variant	-	NC_000009.12:g.107306458C>T	ExAC,gnomAD
rs1159712312	p.Thr105Ile	missense variant	-	NC_000009.12:g.107306464C>T	gnomAD
rs780308925	p.Thr106Ala	missense variant	-	NC_000009.12:g.107306466A>G	ExAC,TOPMed,gnomAD
rs747257394	p.Val107Met	missense variant	-	NC_000009.12:g.107306469G>A	ExAC,gnomAD
rs1339139628	p.Ala108Ser	missense variant	-	NC_000009.12:g.107306472G>T	gnomAD
rs1407780373	p.Ala108Gly	missense variant	-	NC_000009.12:g.107306473C>G	gnomAD
COSM4853535	p.Gln109Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000009.12:g.107306475C>T	NCI-TCGA Cosmic
rs950956301	p.Pro111Ser	missense variant	-	NC_000009.12:g.107306481C>T	TOPMed,gnomAD
rs950956301	p.Pro111Ala	missense variant	-	NC_000009.12:g.107306481C>G	TOPMed,gnomAD
rs776897206	p.Thr112Asn	missense variant	-	NC_000009.12:g.107306485C>A	ExAC,gnomAD
rs1207439891	p.Thr112Ala	missense variant	-	NC_000009.12:g.107306484A>G	TOPMed
NCI-TCGA novel	p.Pro113His	missense variant	-	NC_000009.12:g.107306488C>A	NCI-TCGA
rs1280004247	p.Pro113Ser	missense variant	-	NC_000009.12:g.107306487C>T	gnomAD
rs763010277	p.Pro113Arg	missense variant	-	NC_000009.12:g.107306488C>G	ExAC,TOPMed,gnomAD
rs763010277	p.Pro113Leu	missense variant	-	NC_000009.12:g.107306488C>T	ExAC,TOPMed,gnomAD
COSM1459176	p.Pro115His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107306494C>A	NCI-TCGA Cosmic
rs917424064	p.Ala116Ser	missense variant	-	NC_000009.12:g.107306496G>T	TOPMed,gnomAD
rs773862253	p.Ala116Val	missense variant	-	NC_000009.12:g.107306497C>T	ExAC,gnomAD
rs1461920343	p.Leu117Ser	missense variant	-	NC_000009.12:g.107306500T>C	TOPMed,gnomAD
rs55815226	p.Pro119His	missense variant	-	NC_000009.12:g.107306506C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs55815226	p.Pro119Arg	missense variant	-	NC_000009.12:g.107306506C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1248493574	p.Pro119Ser	missense variant	-	NC_000009.12:g.107306505C>T	TOPMed,gnomAD
rs1434356414	p.Thr120Ala	missense variant	-	NC_000009.12:g.107306508A>G	TOPMed
rs759152448	p.Thr122Ile	missense variant	-	NC_000009.12:g.107306515C>T	ExAC,TOPMed,gnomAD
rs751220555	p.Thr122Ala	missense variant	-	NC_000009.12:g.107306514A>G	ExAC,gnomAD
COSM6114465	p.Ala124Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107306521C>A	NCI-TCGA Cosmic
rs111972101	p.Ala124Val	missense variant	-	NC_000009.12:g.107306521C>T	ESP,ExAC,TOPMed,gnomAD
rs755623960	p.Ser125Pro	missense variant	-	NC_000009.12:g.107306523T>C	ExAC,gnomAD
rs1469987484	p.Ile126Asn	missense variant	-	NC_000009.12:g.107306527T>A	gnomAD
rs1375952090	p.Ile126Leu	missense variant	-	NC_000009.12:g.107306526A>C	TOPMed
rs777629375	p.Pro128Ser	missense variant	-	NC_000009.12:g.107306532C>T	ExAC,gnomAD
rs753831088	p.Ala129Val	missense variant	-	NC_000009.12:g.107306536C>T	ExAC,gnomAD
rs200509488	p.Ala131Val	missense variant	-	NC_000009.12:g.107306542C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1422182733	p.Thr132Ala	missense variant	-	NC_000009.12:g.107306544A>G	TOPMed
rs747228381	p.Thr132Ile	missense variant	-	NC_000009.12:g.107306545C>T	ExAC,TOPMed,gnomAD
rs548841376	p.Ala138Gly	missense variant	-	NC_000009.12:g.107306563C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs548841376	p.Ala138Val	missense variant	-	NC_000009.12:g.107306563C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs773845845	p.Ala140Thr	missense variant	-	NC_000009.12:g.107306568G>A	ExAC,gnomAD
NCI-TCGA novel	p.Ser141Cys	missense variant	-	NC_000009.12:g.107306571A>T	NCI-TCGA
rs141800980	p.Ser141Asn	missense variant	-	NC_000009.12:g.107306572G>A	ESP,TOPMed,gnomAD
rs1481759589	p.Ala142Ser	missense variant	-	NC_000009.12:g.107306574G>T	gnomAD
rs749832557	p.Ala143Ser	missense variant	-	NC_000009.12:g.107306577G>T	ExAC,TOPMed,gnomAD
rs749832557	p.Ala143Thr	missense variant	-	NC_000009.12:g.107306577G>A	ExAC,TOPMed,gnomAD
rs374011602	p.Lys144Gln	missense variant	-	NC_000009.12:g.107306580A>C	ESP,ExAC,TOPMed,gnomAD
rs374011602	p.Lys144Glu	missense variant	-	NC_000009.12:g.107306580A>G	ESP,ExAC,TOPMed,gnomAD
rs1202306409	p.Gln145Arg	missense variant	-	NC_000009.12:g.107306584A>G	gnomAD
rs767087752	p.Lys147Asn	missense variant	-	NC_000009.12:g.107306591G>T	ExAC,TOPMed,gnomAD
rs1159305210	p.Pro148Ser	missense variant	-	NC_000009.12:g.107306592C>T	TOPMed,gnomAD
rs1428226150	p.Pro148Arg	missense variant	-	NC_000009.12:g.107306593C>G	TOPMed,gnomAD
rs1428226150	p.Pro148Leu	missense variant	-	NC_000009.12:g.107306593C>T	TOPMed,gnomAD
rs775135855	p.Ala149Thr	missense variant	-	NC_000009.12:g.107306595G>A	ExAC,gnomAD
COSM4836899	p.Glu150Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107306598G>A	NCI-TCGA Cosmic
rs760163367	p.Lys151Glu	missense variant	-	NC_000009.12:g.107306601A>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro152Ala	missense variant	-	NC_000009.12:g.107306604C>G	NCI-TCGA
rs1459302950	p.Ala153Gly	missense variant	-	NC_000009.12:g.107306608C>G	gnomAD
rs138257027	p.Glu154Gln	missense variant	-	NC_000009.12:g.107306610G>C	ESP,ExAC,gnomAD
rs376087685	p.Thr155Ile	missense variant	-	NC_000009.12:g.107306614C>T	ESP,ExAC,TOPMed,gnomAD
rs765239059	p.Pro156Ala	missense variant	-	NC_000009.12:g.107306616C>G	ExAC,gnomAD
rs750142843	p.Pro156Leu	missense variant	-	NC_000009.12:g.107306617C>T	ExAC,gnomAD
COSM1103635	p.Pro156Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107306616C>T	NCI-TCGA Cosmic
rs758219436	p.Val157Leu	missense variant	-	NC_000009.12:g.107306619G>C	ExAC,gnomAD
rs1293204156	p.Thr159Asn	missense variant	-	NC_000009.12:g.107306626C>A	gnomAD
rs1039142546	p.Pro161Leu	missense variant	-	NC_000009.12:g.107306632C>T	TOPMed
rs781509755	p.Pro161Ser	missense variant	-	NC_000009.12:g.107306631C>T	ExAC,TOPMed,gnomAD
rs748443238	p.Thr162Lys	missense variant	-	NC_000009.12:g.107306635C>A	ExAC,TOPMed,gnomAD
rs1228476488	p.Thr162Ala	missense variant	-	NC_000009.12:g.107306634A>G	gnomAD
rs1224829968	p.Thr164Ala	missense variant	-	NC_000009.12:g.107306640A>G	TOPMed,gnomAD
rs1386224950	p.Asp165Asn	missense variant	-	NC_000009.12:g.107306643G>A	TOPMed
rs1478993300	p.Thr167Ile	missense variant	-	NC_000009.12:g.107311684C>T	TOPMed
rs189555517	p.Ser168Leu	missense variant	-	NC_000009.12:g.107311687C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs763025606	p.Gly169Val	missense variant	-	NC_000009.12:g.107311690G>T	ExAC,gnomAD
rs1443425269	p.Asp170Asn	missense variant	-	NC_000009.12:g.107311692G>A	TOPMed
rs766258521	p.Asp170Gly	missense variant	-	NC_000009.12:g.107311693A>G	ExAC,gnomAD
rs759438239	p.Ser171Cys	missense variant	-	NC_000009.12:g.107311696C>G	ExAC,TOPMed,gnomAD
rs764157337	p.Arg173Trp	missense variant	-	NC_000009.12:g.107311701C>T	ExAC,gnomAD
rs1174975812	p.Ser174Thr	missense variant	-	NC_000009.12:g.107311704T>A	gnomAD
rs754145429	p.Asn175Asp	missense variant	-	NC_000009.12:g.107311707A>G	ExAC,gnomAD
COSM6182118	p.Thr181Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107311725A>G	NCI-TCGA Cosmic
rs1035806432	p.Thr181Met	missense variant	-	NC_000009.12:g.107311726C>T	gnomAD
rs1490827120	p.Thr186Met	missense variant	-	NC_000009.12:g.107318755C>T	NCI-TCGA Cosmic
rs1490827120	p.Thr186Met	missense variant	-	NC_000009.12:g.107318755C>T	TOPMed,gnomAD
COSM3925855	p.Ser189Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107318764C>A	NCI-TCGA Cosmic
rs558671424	p.Glu191Lys	missense variant	-	NC_000009.12:g.107318769G>A	1000Genomes,ExAC,gnomAD
COSM76155	p.Thr195Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107318782C>T	NCI-TCGA Cosmic
COSM3847282	p.Glu196Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107318784G>A	NCI-TCGA Cosmic
rs368633787	p.Met198Leu	missense variant	-	NC_000009.12:g.107318790A>T	ESP,ExAC,gnomAD
rs368633787	p.Met198Val	missense variant	-	NC_000009.12:g.107318790A>G	ESP,ExAC,gnomAD
rs752120411	p.Ser199Leu	missense variant	-	NC_000009.12:g.107318794C>T	ExAC,gnomAD
rs755295616	p.Met200Val	missense variant	-	NC_000009.12:g.107318796A>G	ExAC,gnomAD
rs755295616	p.Met200Leu	missense variant	-	NC_000009.12:g.107318796A>T	ExAC,gnomAD
NCI-TCGA novel	p.Arg204Ter	stop gained	-	NC_000009.12:g.107318808C>T	NCI-TCGA
rs747733273	p.Arg204Gln	missense variant	-	NC_000009.12:g.107318809G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu205Ter	stop gained	-	NC_000009.12:g.107318811G>T	NCI-TCGA
rs1406504932	p.Val207Ala	missense variant	-	NC_000009.12:g.107318818T>C	gnomAD
rs1318073143	p.Ile208Met	missense variant	-	NC_000009.12:g.107318822T>G	gnomAD
rs755747068	p.Ala209Ser	missense variant	-	NC_000009.12:g.107318823G>T	ExAC,TOPMed,gnomAD
COSM267305	p.Ala210Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107318827C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Leu211Met	missense variant	-	NC_000009.12:g.107318829C>A	NCI-TCGA
NCI-TCGA novel	p.Leu211Pro	missense variant	-	NC_000009.12:g.107318830T>C	NCI-TCGA
rs1355110072	p.Ala213Thr	missense variant	-	NC_000009.12:g.107318835G>A	TOPMed
COSM3902834	p.Asn217Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107318848A>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Pro218Ala	missense variant	-	NC_000009.12:g.107318850C>G	NCI-TCGA
NCI-TCGA novel	p.Tyr224Ser	missense variant	-	NC_000009.12:g.107318869A>C	NCI-TCGA
rs201643333	p.Tyr224His	missense variant	-	NC_000009.12:g.107318868T>C	1000Genomes
NCI-TCGA novel	p.Leu226Ser	missense variant	-	NC_000009.12:g.107318875T>C	NCI-TCGA
rs576814919	p.Met227Val	missense variant	-	NC_000009.12:g.107318877A>G	1000Genomes
rs756793941	p.Gly228Arg	missense variant	-	NC_000009.12:g.107321983G>A	ExAC,gnomAD
rs1012270808	p.Gly231Glu	missense variant	-	NC_000009.12:g.107321993G>A	TOPMed
rs1362516465	p.Arg233Ser	missense variant	-	NC_000009.12:g.107322000A>T	gnomAD
rs1051208451	p.Arg233Thr	missense variant	-	NC_000009.12:g.107321999G>C	TOPMed,gnomAD
rs1051208451	p.Arg233Lys	missense variant	-	NC_000009.12:g.107321999G>A	TOPMed,gnomAD
rs377517847	p.Glu234Asp	missense variant	-	NC_000009.12:g.107322003A>T	ESP,ExAC,TOPMed,gnomAD
rs1160326564	p.Gln236Lys	missense variant	-	NC_000009.12:g.107322007C>A	gnomAD
NCI-TCGA novel	p.Ala237Val	missense variant	-	NC_000009.12:g.107322011C>T	NCI-TCGA
rs1429107999	p.Ala237Thr	missense variant	-	NC_000009.12:g.107322010G>A	gnomAD
NCI-TCGA novel	p.Val239Ile	missense variant	-	NC_000009.12:g.107322016G>A	NCI-TCGA
rs146092388	p.Pro241Arg	missense variant	-	NC_000009.12:g.107322023C>G	ESP,ExAC,TOPMed
rs768496304	p.Pro241Ser	missense variant	-	NC_000009.12:g.107322022C>T	ExAC,gnomAD
rs759569833	p.Pro242Ala	missense variant	-	NC_000009.12:g.107322025C>G	ExAC,gnomAD
rs759569833	p.Pro242Ser	missense variant	-	NC_000009.12:g.107322025C>T	ExAC,gnomAD
rs1411623808	p.Pro242His	missense variant	-	NC_000009.12:g.107322026C>A	gnomAD
COSM3413227	p.Gln243Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000009.12:g.107322028C>T	NCI-TCGA Cosmic
rs1322498116	p.Ala245Val	missense variant	-	NC_000009.12:g.107322035C>T	TOPMed,gnomAD
rs1221472751	p.Ser246Thr	missense variant	-	NC_000009.12:g.107322038G>C	gnomAD
rs1423546846	p.Ser246Gly	missense variant	-	NC_000009.12:g.107322037A>G	gnomAD
rs1257943170	p.Thr247Ala	missense variant	-	NC_000009.12:g.107322040A>G	gnomAD
rs1805329	p.Ala249Val	missense variant	-	NC_000009.12:g.107322047C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1805329	p.Ala249Val	missense variant	-	NC_000009.12:g.107322047C>T	UniProt,dbSNP
VAR_014350	p.Ala249Val	missense variant	-	NC_000009.12:g.107322047C>T	UniProt
rs149794634	p.Pro250Ser	missense variant	-	NC_000009.12:g.107322049C>T	ESP,ExAC,TOPMed,gnomAD
rs1484321441	p.Ser252Cys	missense variant	-	NC_000009.12:g.107322056C>G	gnomAD
rs144801847	p.Ala257Thr	missense variant	-	NC_000009.12:g.107322070G>A	ESP,ExAC,gnomAD
rs756916777	p.Ala257Gly	missense variant	-	NC_000009.12:g.107322071C>G	ExAC,gnomAD
rs148559163	p.Ala259Thr	missense variant	-	NC_000009.12:g.107322076G>A	ESP,ExAC,TOPMed,gnomAD
rs1195024005	p.Ala260Thr	missense variant	-	NC_000009.12:g.107322079G>A	TOPMed
rs201887317	p.Thr261Ala	missense variant	-	NC_000009.12:g.107322082A>G	ExAC,TOPMed,gnomAD
rs372514872	p.Thr262Met	missense variant	-	NC_000009.12:g.107322086C>T	ESP,ExAC,TOPMed,gnomAD
rs780025783	p.Thr262Ala	missense variant	-	NC_000009.12:g.107322085A>G	ExAC,gnomAD
NCI-TCGA novel	p.Thr263Ile	missense variant	-	NC_000009.12:g.107322089C>T	NCI-TCGA
rs1308492422	p.Thr263Ala	missense variant	-	NC_000009.12:g.107322088A>G	gnomAD
NCI-TCGA novel	p.Ala264Val	missense variant	-	NC_000009.12:g.107322092C>T	NCI-TCGA
rs747959796	p.Thr265Ala	missense variant	-	NC_000009.12:g.107322094A>G	ExAC,TOPMed,gnomAD
rs985132401	p.Thr265Arg	missense variant	-	NC_000009.12:g.107322095C>G	TOPMed,gnomAD
rs985132401	p.Thr265Ile	missense variant	-	NC_000009.12:g.107322095C>T	TOPMed,gnomAD
rs56157506	p.Thr269Arg	missense variant	-	NC_000009.12:g.107322107C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ser271Tyr	missense variant	-	NC_000009.12:g.107322113C>A	NCI-TCGA
rs776063038	p.Ser271Phe	missense variant	-	NC_000009.12:g.107322113C>T	ExAC,TOPMed,gnomAD
rs1421977074	p.His274Tyr	missense variant	-	NC_000009.12:g.107323892C>T	gnomAD
COSM3652681	p.Pro275Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107323896C>T	NCI-TCGA Cosmic
rs1166756938	p.Pro275Ser	missense variant	-	NC_000009.12:g.107323895C>T	gnomAD
rs144174357	p.Arg280Trp	missense variant	-	NC_000009.12:g.107323910C>T	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gln284Glu	missense variant	-	NC_000009.12:g.107323922C>G	NCI-TCGA
rs1340466231	p.Met288Ile	missense variant	-	NC_000009.12:g.107323936G>A	TOPMed
COSM455109	p.Arg289Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107323938G>A	NCI-TCGA Cosmic
rs1294499471	p.Gln290His	missense variant	-	NC_000009.12:g.107323942A>T	TOPMed
rs760865069	p.Ile291Val	missense variant	-	NC_000009.12:g.107323943A>G	ExAC,TOPMed,gnomAD
rs1436136403	p.Ile292Thr	missense variant	-	NC_000009.12:g.107323947T>C	gnomAD
rs769215825	p.Gln293Arg	missense variant	-	NC_000009.12:g.107323950A>G	ExAC,gnomAD
COSM3652682	p.Pro296Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107323959C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ser297Phe	missense variant	-	NC_000009.12:g.107323962C>T	NCI-TCGA
rs777289896	p.Ala301Val	missense variant	-	NC_000009.12:g.107323974C>T	ExAC,TOPMed,gnomAD
COSM3779515	p.Gln305His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107323987G>C	NCI-TCGA Cosmic
rs1391588245	p.Ile306Met	missense variant	-	NC_000009.12:g.107323990A>G	gnomAD
rs140228782	p.Arg308Gln	missense variant	-	NC_000009.12:g.107323995G>A	ESP,ExAC,TOPMed,gnomAD
rs1167069133	p.Arg308Ter	stop gained	-	NC_000009.12:g.107323994C>T	TOPMed
NCI-TCGA novel	p.Glu309Asp	missense variant	-	NC_000009.12:g.107323999G>T	NCI-TCGA
COSM3847283	p.Gln312Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107324006C>G	NCI-TCGA Cosmic
rs767388236	p.Gln315Glu	missense variant	-	NC_000009.12:g.107324015C>G	ExAC,gnomAD
rs1179993104	p.Gln316His	missense variant	-	NC_000009.12:g.107324836A>C	gnomAD
rs1253902557	p.Ser318Gly	missense variant	-	NC_000009.12:g.107324840A>G	gnomAD
rs1284381289	p.Gln319Arg	missense variant	-	NC_000009.12:g.107324844A>G	TOPMed,gnomAD
rs755952661	p.His323Asp	missense variant	-	NC_000009.12:g.107324855C>G	ExAC,gnomAD
rs755952661	p.His323Tyr	missense variant	-	NC_000009.12:g.107324855C>T	ExAC,gnomAD
rs1477360038	p.Gln326His	missense variant	-	NC_000009.12:g.107324866G>C	TOPMed
NCI-TCGA novel	p.Gly336Val	missense variant	-	NC_000009.12:g.107324895G>T	NCI-TCGA
rs757084565	p.Gly337Ser	missense variant	-	NC_000009.12:g.107324897G>A	ExAC,TOPMed,gnomAD
rs1427920102	p.Gly337Ala	missense variant	-	NC_000009.12:g.107324898G>C	gnomAD
COSM4822540	p.Gly339Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107324904G>C	NCI-TCGA Cosmic
rs1351678324	p.Gly339Glu	missense variant	-	NC_000009.12:g.107324904G>A	gnomAD
rs780125343	p.Gly341Ter	stop gained	-	NC_000009.12:g.107324909G>T	ExAC,gnomAD
rs1040382251	p.Gly341Glu	missense variant	-	NC_000009.12:g.107324910G>A	TOPMed
rs755075731	p.Gly343Glu	missense variant	-	NC_000009.12:g.107324916G>A	ExAC,TOPMed,gnomAD
rs1365012593	p.Gly343Arg	missense variant	-	NC_000009.12:g.107324915G>A	gnomAD
rs781468979	p.Gly344Asp	missense variant	-	NC_000009.12:g.107324919G>A	ExAC,gnomAD
COSM3432744	p.Gly345Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107324922G>A	NCI-TCGA Cosmic
rs770162049	p.Ile349Thr	missense variant	-	NC_000009.12:g.107324934T>C	ExAC,gnomAD
rs748261610	p.Ile349Val	missense variant	-	NC_000009.12:g.107324933A>G	ExAC,TOPMed,gnomAD
rs1483371594	p.Glu351Gly	missense variant	-	NC_000009.12:g.107324940A>G	gnomAD
COSM1103638	p.Ala352Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107324942G>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ala352Thr	missense variant	-	NC_000009.12:g.107324942G>A	NCI-TCGA
NCI-TCGA novel	p.Ser354Arg	missense variant	-	NC_000009.12:g.107324950T>G	NCI-TCGA
rs773774956	p.Ser354Asn	missense variant	-	NC_000009.12:g.107324949G>A	ExAC,gnomAD
rs1244831507	p.Gly355Val	missense variant	-	NC_000009.12:g.107324952G>T	gnomAD
rs749558086	p.His356Arg	missense variant	-	NC_000009.12:g.107324955A>G	ExAC,gnomAD
rs1419081449	p.Gln361Glu	missense variant	-	NC_000009.12:g.107324969C>G	gnomAD
rs773992502	p.Pro364Ala	missense variant	-	NC_000009.12:g.107324978C>G	ExAC,gnomAD
rs201813616	p.Gln365Ter	stop gained	-	NC_000009.12:g.107324981C>T	1000Genomes
rs1170587715	p.Glu366Ala	missense variant	-	NC_000009.12:g.107324985A>C	gnomAD
rs1468474780	p.Glu371Asp	missense variant	-	NC_000009.12:g.107325001A>C	gnomAD
rs768029751	p.Ala375Pro	missense variant	-	NC_000009.12:g.107329549G>C	ExAC,gnomAD
COSM1222993	p.Gly377Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107329555G>A	NCI-TCGA Cosmic
COSM1103639	p.Val383Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107329574T>C	NCI-TCGA Cosmic
rs1184982125	p.Ala386Val	missense variant	-	NC_000009.12:g.107329583C>T	TOPMed
COSM1103640	p.Tyr387His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107329585T>C	NCI-TCGA Cosmic
COSM3847284	p.Glu394Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000009.12:g.107329606G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ala398Thr	missense variant	-	NC_000009.12:g.107329618G>A	NCI-TCGA
NCI-TCGA novel	p.Leu401Phe	missense variant	-	NC_000009.12:g.107329627C>T	NCI-TCGA
rs1270526977	p.Leu402Ile	missense variant	-	NC_000009.12:g.107329630C>A	gnomAD
rs769787918	p.Asn405Lys	missense variant	-	NC_000009.12:g.107329641C>G	ExAC,gnomAD
NCI-TCGA novel	p.Asp407Asn	missense variant	-	NC_000009.12:g.107329645G>A	NCI-TCGA
NCI-TCGA novel	p.Ter410LeuGluUnkThrTerUnkUnk	stop lost	-	NC_000009.12:g.107329655G>T	NCI-TCGA

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0002395	Alzheimer's Disease	disease	BEFREE
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0007107	Malignant neoplasm of larynx	disease	BEFREE
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE
C0014859	Esophageal Neoplasms	group	BEFREE
C0021364	Male infertility	disease	CTD_human
C0024282	Lymphocytosis	disease	BEFREE
C0024301	Lymphoma, Follicular	disease	BEFREE
C0026764	Multiple Myeloma	disease	LHGDN
C0033578	Prostatic Neoplasms	group	CTD_human
C0036323	Schistosomiasis	disease	BEFREE
C0079773	Lymphoma, T-Cell, Cutaneous	disease	BEFREE
C0152018	Esophageal carcinoma	disease	BEFREE
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0345967	Malignant mesothelioma	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE;CTD_human
C0376634	Craniofacial Abnormalities	group	CTD_human
C0546837	Malignant neoplasm of esophagus	disease	BEFREE
C0595989	Carcinoma of larynx	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0684249	Carcinoma of lung	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0812413	Malignant Pleural Mesothelioma	disease	BEFREE
C0848676	Subfertility, Male	phenotype	CTD_human
C0917731	Male sterility	phenotype	CTD_human
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1458155	Mammary Neoplasms	group	LHGDN
C2239176	Liver carcinoma	disease	BEFREE;LHGDN
C2752147	XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C	disease	BEFREE
C2931689	Dystrophia myotonica 2	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0003684	damaged DNA binding	IEA
GO:0003697	single-stranded DNA binding	TAS
GO:0005515	protein binding	IPI
GO:0031593	polyubiquitin modification-dependent protein binding	IDA
GO:0031593	polyubiquitin modification-dependent protein binding	IBA
GO:0043130	ubiquitin binding	IBA
GO:0070628	proteasome binding	IBA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000715	nucleotide-excision repair, DNA damage recognition	IDA
GO:0000715	nucleotide-excision repair, DNA damage recognition	TAS
GO:0000717	nucleotide-excision repair, DNA duplex unwinding	TAS
GO:0006289	nucleotide-excision repair	IDA
GO:0006294	nucleotide-excision repair, preincision complex assembly	TAS
GO:0006457	protein folding	TAS
GO:0007283	spermatogenesis	IEA
GO:0016579	protein deubiquitination	TAS
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0048568	embryonic organ development	IEA
GO:0070911	global genome nucleotide-excision repair	TAS
GO:0098761	cellular response to interleukin-7	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0000502	proteasome complex	IEA
GO:0005634	nucleus	TAS
GO:0005654	nucleoplasm	IDA
GO:0005654	nucleoplasm	IBA
GO:0005654	nucleoplasm	TAS
GO:0005829	cytosol	IDA
GO:0005829	cytosol	IBA
GO:0005829	cytosol	TAS
GO:0071942	XPC complex	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689877	Josephin domain DUBs	TAS
R-HSA-5696394	DNA Damage Recognition in GG-NER	TAS
R-HSA-5696395	Formation of Incision Complex in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73894	DNA Repair	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C063002	2,3-dimethoxy-1,4-naphthoquinone	2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of RAD23B mRNA	19031421
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]	21742020
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene affects the expression of RAD23B mRNA	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RAD23B mRNA	20816883
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RAD23B mRNA	20816883
C533410	2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one	2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one affects the expression of RAD23B mRNA	19946333
C533410	2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one	TP53 protein affects the reaction [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one affects the expression of RAD23B mRNA]	19946333
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of RAD23B mRNA	18648102
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of RAD23B mRNA	19038236
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAD23B mRNA	19150397
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RAD23B mRNA	20018196; 26238291;
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of RAD23B gene	27153756
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of RAD23B mRNA	24449571
D000077237	Arsenic Trioxide	[Tretinoin co-treated with Arsenic Trioxide] results in increased expression of RAD23B protein	15894607
D001280	Atrazine	Atrazine results in increased expression of RAD23B mRNA	18522720
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RAD23B mRNA	25612249
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RAD23B mRNA	28461126
C044887	beta-methylcholine	beta-methylcholine affects the expression of RAD23B mRNA	21179406
C006780	bisphenol A	bisphenol A results in decreased methylation of RAD23B gene	28582417
C006780	bisphenol A	bisphenol A results in increased expression of RAD23B mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of RAD23B mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of RAD23B mRNA	25181051; 30816183;
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of RAD23B mRNA	25270620
C515564	bromovanin	bromovanin results in decreased expression of RAD23B protein	21419150
C028031	cadmium acetate	cadmium acetate results in decreased expression of RAD23B mRNA	18155341
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of RAD23B mRNA	12160620; 26472689;
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of RAD23B mRNA	11958953
D019256	Cadmium Chloride	MT1 affects the reaction [Cadmium Chloride results in increased expression of RAD23B mRNA]	11958953
D019256	Cadmium Chloride	MT2 affects the reaction [Cadmium Chloride results in increased expression of RAD23B mRNA]	11958953
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of RAD23B mRNA	31150632
D000068579	Celecoxib	Celecoxib results in decreased expression of RAD23B mRNA	28201806
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of RAD23B mRNA	23650126
C007020	chlorophyllin	chlorophyllin analog results in decreased expression of RAD23B protein	22852132
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAD23B	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAD23B gene	20938992
D002945	Cisplatin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]	21742020
D002945	Cisplatin	Cisplatin results in increased expression of RAD23B protein	21742020
D002945	Cisplatin	RAD23B mutant form inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]	21742020
D002945	Cisplatin	RAD23B mutant form inhibits the reaction [Cisplatin results in increased expression of TP53 protein]	21742020
D002945	Cisplatin	RAD23B mutant form inhibits the reaction [Cisplatin results in increased expression of XPC protein]	21742020
D002945	Cisplatin	RAD23B results in decreased susceptibility to Cisplatin	21742020
D002945	Cisplatin	RAD23B results in increased susceptibility to Cisplatin	21878529
D002945	Cisplatin	U 0126 inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]	21742020
D002945	Cisplatin	Wortmannin inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]	21742020
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in increased expression of RAD23B mRNA	21878529
D016572	Cyclosporine	Cyclosporine results in increased expression of RAD23B mRNA	20106945; 25562108;
D000077209	Decitabine	[Decitabine co-treated with Depsipeptides] results in decreased expression of RAD23B mRNA	17064661
D047630	Depsipeptides	[Decitabine co-treated with Depsipeptides] results in decreased expression of RAD23B mRNA	17064661
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RAD23B mRNA]	27941970
D004026	Dieldrin	Dieldrin results in increased expression of RAD23B mRNA	20438755
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of RAD23B mRNA	17023530
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of RAD23B mRNA	19031421
D004317	Doxorubicin	Doxorubicin affects the expression of RAD23B protein	29385562
D004317	Doxorubicin	Doxorubicin results in decreased expression of RAD23B mRNA	29803840
D004726	Endosulfan	Endosulfan results in increased expression of RAD23B mRNA	29391264
D004726	Endosulfan	Endosulfan results in increased expression of RAD23B mRNA	25569846
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RAD23B protein	23301498
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of RAD23B mRNA	25612249
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of RAD23B mRNA	23649840
D018120	Finasteride	Finasteride results in increased expression of RAD23B mRNA	24136188
D005472	Fluorouracil	Fluorouracil results in increased expression of RAD23B mRNA	15109396
D005472	Fluorouracil	RAD23B affects the susceptibility to Fluorouracil	15067352
D005485	Flutamide	Flutamide results in increased expression of RAD23B mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAD23B	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAD23B gene	20938992
D005742	Gasoline	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of RAD23B mRNA	29432896
C000593030	GSK-J4	GSK-J4 results in increased expression of RAD23B mRNA	29301935
D007213	Indomethacin	Indomethacin results in decreased expression of RAD23B mRNA	16984733
D007213	Indomethacin	Indomethacin results in decreased expression of RAD23B mRNA	28201806
D000077146	Irinotecan	Irinotecan metabolite results in decreased expression of RAD23B mRNA	15956246
D000077146	Irinotecan	Irinotecan results in decreased expression of RAD23B mRNA	15956246
C040507	isobutyl alcohol	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of RAD23B mRNA	29432896
C561695	(+)-JQ1 compound	(+)-JQ1 compound analog binds to RAD23B protein	24972113
D007854	Lead	Lead affects the splicing of RAD23B mRNA	28903495
D000077339	Leflunomide	Leflunomide results in increased expression of RAD23B mRNA	24136188
D008610	Menthol	Menthol results in decreased expression of RAD23B mRNA	26760959
D008713	Methimazole	Methimazole results in decreased expression of RAD23B mRNA	22504374
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAD23B	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAD23B gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of RAD23B mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of RAD23B mRNA	23649840
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of RAD23B mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of RAD23B mRNA	25554681
C051752	nefazodone	nefazodone results in increased expression of RAD23B mRNA	24136188
D018817	N-Methyl-3,4-methylenedioxyamphetamine	N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RAD23B mRNA	20188158
D000077150	Oxaliplatin	[Oxaliplatin co-treated with Topotecan] results in decreased expression of RAD23B mRNA	25729387
D010100	Oxygen	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of RAD23B mRNA	30529165
D052638	Particulate Matter	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of RAD23B mRNA	29432896
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of RAD23B protein	22609092
D010634	Phenobarbital	Phenobarbital affects the expression of RAD23B mRNA	23091169
D010862	Pilocarpine	Pilocarpine results in increased expression of RAD23B mRNA	17971868
C049032	pinosylvin	pinosylvin results in decreased expression of RAD23B mRNA	23333577
C014153	pirimiphos methyl	pirimiphos methyl results in decreased expression of RAD23B mRNA	27845199
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RAD23B mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of RAD23B mRNA	18301758
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of RAD23B mRNA	21334430
D011084	Polycyclic Aromatic Hydrocarbons	[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of RAD23B mRNA	29432896
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of RAD23B mRNA	22504374
D000077185	Resveratrol	Resveratrol affects the expression of RAD23B mRNA	15748624
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of RAD23B mRNA	21427059
C010327	salinomycin	salinomycin results in decreased expression of RAD23B mRNA	19682730
D012643	Selenium	Selenium results in decreased expression of RAD23B mRNA	19244175
C009277	sodium arsenate	sodium arsenate results in decreased expression of RAD23B mRNA	21795629
C009277	sodium arsenate	sodium arsenate results in increased expression of RAD23B mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in increased expression of RAD23B mRNA	29361514
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of RAD23B mRNA	31299295
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RAD23B mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RAD23B mRNA	20159946
D019284	Thapsigargin	Thapsigargin results in decreased expression of RAD23B protein	24648495
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of RAD23B protein	30291989
D019772	Topotecan	[Oxaliplatin co-treated with Topotecan] results in decreased expression of RAD23B mRNA	25729387
D014212	Tretinoin	[Tretinoin co-treated with Arsenic Trioxide] results in increased expression of RAD23B protein	15894607
C012589	trichostatin A	trichostatin A affects the expression of RAD23B mRNA	28542535
C113580	U 0126	U 0126 inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]	21742020
C406224	valdecoxib	valdecoxib results in increased expression of RAD23B mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in increased expression of RAD23B mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in decreased expression of RAD23B mRNA	21427059
D014810	Vitamin E	Vitamin E results in decreased expression of RAD23B mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 affects the expression of RAD23B mRNA	20044591
D000077191	Wortmannin	Wortmannin inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]	21742020
D015032	Zinc	Zinc deficiency results in increased expression of RAD23B mRNA	11739864

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0025	Alternative splicing
KW-0963	Cytoplasm
KW-0903	Direct protein sequencing
KW-0227	DNA damage
KW-0234	DNA repair
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-0647	Proteasome
KW-1185	Reference proteome
KW-0677	Repeat
KW-0833	Ubl conjugation pathway

Interpro

InterPro ID	InterPro Term
IPR004806	Rad23
IPR041811	RAD23A/B_UBA1
IPR006636	STI1_HS-bd
IPR015940	UBA
IPR009060	UBA-like_sf
IPR000626	Ubiquitin-like_dom
IPR029071	Ubiquitin-like_domsf
IPR015360	XPC-bd
IPR036353	XPC-bd_sf

PROSITE

PROSITE ID	PROSITE Term
PS50030	UBA
PS50053	UBIQUITIN_2

Pfam

Pfam ID	Pfam Term
PF00627	UBA
PF00240	ubiquitin
PF09280	XPC-binding

Gene: RAD23B

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction