CleftGeneDB-Search

Gene: WNT3A

Basic information

Tag	Content
Uniprot ID	P56704; Q3SY79; Q3SY80; Q969P2;
Entrez ID	89780
Genbank protein ID	AAI03924.1; BAB61052.1; AAI03923.1; AAI03922.1; BAB71136.1;
Genbank nucleotide ID	NM_033131.3
Ensembl protein ID	ENSP00000284523
Ensembl nucleotide ID	ENSG00000154342
Gene name	Protein Wnt-3a
Gene symbol	WNT3A
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Manually collected
Reference	18413325
Functional description	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720).
Sequence	MAPLGYFLLL CSLKQALGSY PIWWSLAVGP QYSSLGSQPI LCASIPGLVP KQLRFCRNYV 60 EIMPSVAEGI KIGIQECQHQ FRGRRWNCTT VHDSLAIFGP VLDKATRESA FVHAIASAGV 120 AFAVTRSCAE GTAAICGCSS RHQGSPGKGW KWGGCSEDIE FGGMVSREFA DARENRPDAR 180 SAMNRHNNEA GRQAIASHMH LKCKCHGLSG SCEVKTCWWS QPDFRAIGDF LKDKYDSASE 240 MVVEKHRESR GWVETLRPRY TYFKVPTERD LVYYEASPNF CEPNPETGSF GTRDRTCNVS 300 SHGIDGCDLL CCGRGHNARA ERRREKCRCV FHWCCYVSCQ ECTRVYDVHT CK 352

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	WNT3A		A0A452ETX2			Capra hircus	Prediction	More>>
1:1 ortholog	WNT3A	89780	P56704			Homo sapiens	Publication	More>>
1:1 ortholog	Wnt3a	22416	P27467	CPO	E14.5	Mus musculus	Publication	More>>
1:1 ortholog	WNT3A	100615247	H2R817			Pan troglodytes	Prediction	More>>
1:1 ortholog		100514950	A0A480RFN3			Sus scrofa	Prediction	More>>
1:1 ortholog	WNT3A	100354583	G1SKY6			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Wnt3a	303181	F1M077			Rattus norvegicus	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
WNT3A	rs1745420	Genotyping; PDT; and APL	18413325

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs769083925	p.Pro3Ser	missense variant	-	NC_000001.11:g.228007135C>T	ExAC,gnomAD
rs1369668727	p.Leu4Pro	missense variant	-	NC_000001.11:g.228007139T>C	gnomAD
rs1244397785	p.Gly5Arg	missense variant	-	NC_000001.11:g.228007141G>C	gnomAD
rs1219061838	p.Leu10Phe	missense variant	-	NC_000001.11:g.228007156C>T	gnomAD
rs773485951	p.Ser12Asn	missense variant	-	NC_000001.11:g.228007163G>A	ExAC,gnomAD
rs773485951	p.Ser12Ile	missense variant	-	NC_000001.11:g.228007163G>T	ExAC,gnomAD
rs747083898	p.Ala16Thr	missense variant	-	NC_000001.11:g.228007174G>A	ExAC,gnomAD
rs989317880	p.Ala16Val	missense variant	-	NC_000001.11:g.228007175C>T	TOPMed,gnomAD
rs747083898	p.Ala16Ser	missense variant	-	NC_000001.11:g.228007174G>T	ExAC,gnomAD
NCI-TCGA novel	p.Gly18Arg	missense variant	-	NC_000001.11:g.228007180G>C	NCI-TCGA
rs771033634	p.Ser19Asn	missense variant	-	NC_000001.11:g.228007184G>A	ExAC,gnomAD
rs1314260795	p.Ser19Cys	missense variant	-	NC_000001.11:g.228007183A>T	TOPMed
rs532168900	p.Ile22Met	missense variant	-	NC_000001.11:g.228007194C>G	1000Genomes,ExAC,gnomAD
rs745831522	p.Ser25Leu	missense variant	-	NC_000001.11:g.228022669C>T	NCI-TCGA,NCI-TCGA Cosmic
rs745831522	p.Ser25Trp	missense variant	-	NC_000001.11:g.228022669C>G	ExAC,gnomAD
rs745831522	p.Ser25Leu	missense variant	-	NC_000001.11:g.228022669C>T	ExAC,gnomAD
COSM1962695	p.Ala27Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228022675C>T	NCI-TCGA Cosmic
COSM293041	p.Val28Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228022678T>C	NCI-TCGA Cosmic
rs192966556	p.Pro30Leu	missense variant	-	NC_000001.11:g.228022684C>T	1000Genomes,ExAC,gnomAD
rs1329090456	p.Pro30Ser	missense variant	-	NC_000001.11:g.228022683C>T	gnomAD
rs1186454652	p.Ser34Phe	missense variant	-	NC_000001.11:g.228022696C>T	gnomAD
rs1354332166	p.Gly36Asp	missense variant	-	NC_000001.11:g.228022702G>A	gnomAD
rs761411292	p.Ser37Leu	missense variant	-	NC_000001.11:g.228022705C>T	NCI-TCGA,NCI-TCGA Cosmic
rs761411292	p.Ser37Leu	missense variant	-	NC_000001.11:g.228022705C>T	ExAC,TOPMed,gnomAD
rs755569705	p.Pro39Ser	missense variant	-	NC_000001.11:g.228022710C>T	NCI-TCGA,NCI-TCGA Cosmic
rs755569705	p.Pro39Ser	missense variant	-	NC_000001.11:g.228022710C>T	ExAC
rs1421075800	p.Ser44Arg	missense variant	-	NC_000001.11:g.228022727C>A	gnomAD
rs1156613570	p.Pro46Leu	missense variant	-	NC_000001.11:g.228022732C>T	NCI-TCGA Cosmic
rs1156613570	p.Pro46Leu	missense variant	-	NC_000001.11:g.228022732C>T	TOPMed,gnomAD
rs139491436	p.Gly47Val	missense variant	-	NC_000001.11:g.228022735G>T	ESP
NCI-TCGA novel	p.Pro50His	missense variant	-	NC_000001.11:g.228022744C>A	NCI-TCGA
rs145797401	p.Lys51Met	missense variant	-	NC_000001.11:g.228022747A>T	ESP,ExAC,TOPMed,gnomAD
rs145797401	p.Lys51Arg	missense variant	-	NC_000001.11:g.228022747A>G	ESP,ExAC,TOPMed,gnomAD
rs1335028571	p.Arg54His	missense variant	-	NC_000001.11:g.228022756G>A	NCI-TCGA Cosmic
rs908046368	p.Arg54Cys	missense variant	-	NC_000001.11:g.228022755C>T	TOPMed,gnomAD
rs1335028571	p.Arg54His	missense variant	-	NC_000001.11:g.228022756G>A	TOPMed
rs908046368	p.Arg54Cys	missense variant	-	NC_000001.11:g.228022755C>T	NCI-TCGA
rs1442903743	p.Arg57Lys	missense variant	-	NC_000001.11:g.228022765G>A	TOPMed
rs1466538942	p.Tyr59Phe	missense variant	-	NC_000001.11:g.228022771A>T	gnomAD
rs199976080	p.Val60Met	missense variant	-	NC_000001.11:g.228022773G>A	ExAC,TOPMed,gnomAD
COSM3789572	p.Glu61Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228022778G>T	NCI-TCGA Cosmic
rs1399260520	p.Ile62Val	missense variant	-	NC_000001.11:g.228022779A>G	gnomAD
rs779941062	p.Ile62Met	missense variant	-	NC_000001.11:g.228022781C>G	ExAC,gnomAD
rs749172940	p.Met63Thr	missense variant	-	NC_000001.11:g.228022783T>C	ExAC,gnomAD
NCI-TCGA novel	p.Pro64His	missense variant	-	NC_000001.11:g.228022786C>A	NCI-TCGA
rs1324848850	p.Pro64Ala	missense variant	-	NC_000001.11:g.228022785C>G	TOPMed
NCI-TCGA novel	p.Ser65Arg	missense variant	-	NC_000001.11:g.228022790C>A	NCI-TCGA
rs774063132	p.Val66Leu	missense variant	-	NC_000001.11:g.228022791G>T	ExAC,TOPMed,gnomAD
rs774063132	p.Val66Met	missense variant	-	NC_000001.11:g.228022791G>A	ExAC,TOPMed,gnomAD
rs548478697	p.Glu68Lys	missense variant	-	NC_000001.11:g.228022797G>A	NCI-TCGA,NCI-TCGA Cosmic
rs548478697	p.Glu68Lys	missense variant	-	NC_000001.11:g.228022797G>A	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ile70Thr	missense variant	-	NC_000001.11:g.228022804T>C	NCI-TCGA
COSM1339434	p.Lys71Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228022807A>G	NCI-TCGA Cosmic
rs760074981	p.Ile72Ser	missense variant	-	NC_000001.11:g.228022810T>G	ExAC,gnomAD
rs772847803	p.Ile72Val	missense variant	-	NC_000001.11:g.228022809A>G	ExAC,TOPMed,gnomAD
rs760074981	p.Ile72Thr	missense variant	-	NC_000001.11:g.228022810T>C	ExAC,gnomAD
NCI-TCGA novel	p.Glu76Val	missense variant	-	NC_000001.11:g.228022822A>T	NCI-TCGA
rs1346108878	p.Glu76Ter	stop gained	-	NC_000001.11:g.228022821G>T	TOPMed,gnomAD
rs1280235364	p.Cys77Arg	missense variant	-	NC_000001.11:g.228022824T>C	gnomAD
rs147742383	p.His79Tyr	missense variant	-	NC_000001.11:g.228022830C>T	ESP,TOPMed
rs142644449	p.Arg82His	missense variant	-	NC_000001.11:g.228022840G>A	NCI-TCGA
rs142644449	p.Arg82His	missense variant	-	NC_000001.11:g.228022840G>A	ESP,ExAC,TOPMed,gnomAD
rs753280205	p.Arg82Cys	missense variant	-	NC_000001.11:g.228022839C>T	ExAC,gnomAD
rs371989231	p.Gly83Ser	missense variant	-	NC_000001.11:g.228022842G>A	ESP,ExAC,TOPMed,gnomAD
rs750564361	p.Arg84His	missense variant	-	NC_000001.11:g.228022846G>A	ExAC,gnomAD
rs750564361	p.Arg84His	missense variant	-	NC_000001.11:g.228022846G>A	NCI-TCGA,NCI-TCGA Cosmic
rs757565394	p.Arg84Gly	missense variant	-	NC_000001.11:g.228022845C>G	ExAC,TOPMed,gnomAD
rs757565394	p.Arg84Cys	missense variant	-	NC_000001.11:g.228022845C>T	ExAC,TOPMed,gnomAD
rs780065621	p.Arg85Trp	missense variant	-	NC_000001.11:g.228022848C>T	NCI-TCGA
rs780065621	p.Arg85Trp	missense variant	-	NC_000001.11:g.228022848C>T	ExAC,gnomAD
rs749224268	p.Arg85Gln	missense variant	-	NC_000001.11:g.228022849G>A	ExAC,TOPMed,gnomAD
COSM3484405	p.Trp86Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000001.11:g.228022853G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Trp86Cys	missense variant	-	NC_000001.11:g.228022853G>T	NCI-TCGA
NCI-TCGA novel	p.Trp86Ter	stop gained	-	NC_000001.11:g.228022852G>A	NCI-TCGA
COSM6061613	p.Asn87Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228022856C>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Thr90Ala	missense variant	-	NC_000001.11:g.228022863A>G	NCI-TCGA
rs572229142	p.Val91Ile	missense variant	-	NC_000001.11:g.228022866G>A	ExAC,TOPMed,gnomAD
rs201274685	p.Asp93Asn	missense variant	-	NC_000001.11:g.228022872G>A	ExAC,TOPMed,gnomAD
rs760328956	p.Leu95Gln	missense variant	-	NC_000001.11:g.228022879T>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala96Val	missense variant	-	NC_000001.11:g.228022882C>T	NCI-TCGA
NCI-TCGA novel	p.Ala96Thr	missense variant	-	NC_000001.11:g.228022881G>A	NCI-TCGA
rs371944998	p.Ala96Ser	missense variant	-	NC_000001.11:g.228022881G>T	ESP,ExAC,TOPMed,gnomAD
rs776215625	p.Ile97Val	missense variant	-	NC_000001.11:g.228022884A>G	ExAC,TOPMed,gnomAD
rs763611956	p.Phe98Leu	missense variant	-	NC_000001.11:g.228022887T>C	ExAC,gnomAD
rs762060880	p.Pro100Leu	missense variant	-	NC_000001.11:g.228022894C>T	ExAC,gnomAD
rs752010161	p.Pro100Ser	missense variant	-	NC_000001.11:g.228022893C>T	ExAC,gnomAD
rs756289627	p.Val101Met	missense variant	-	NC_000001.11:g.228022896G>A	ExAC,TOPMed,gnomAD
rs1444107117	p.Glu108Asp	missense variant	-	NC_000001.11:g.228050666G>T	gnomAD
rs752609956	p.Ser109Leu	missense variant	-	NC_000001.11:g.228050668C>T	NCI-TCGA
rs752609956	p.Ser109Leu	missense variant	-	NC_000001.11:g.228050668C>T	ExAC,gnomAD
rs1246405858	p.Ala110Gly	missense variant	-	NC_000001.11:g.228050671C>G	gnomAD
COSM6124808	p.Phe111Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228050674T>G	NCI-TCGA Cosmic
rs1416614180	p.Phe111Ser	missense variant	-	NC_000001.11:g.228050674T>C	TOPMed
COSM3484407	p.His113Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228050679C>T	NCI-TCGA Cosmic
rs757010599	p.Ala114Thr	missense variant	-	NC_000001.11:g.228050682G>A	ExAC,TOPMed,gnomAD
rs745466989	p.Ile115Met	missense variant	-	NC_000001.11:g.228050687T>G	ExAC,TOPMed,gnomAD
COSM6124806	p.Ser117Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000001.11:g.228050692C>A	NCI-TCGA Cosmic
rs753888521	p.Gly119Asp	missense variant	-	NC_000001.11:g.228050698G>A	ExAC,gnomAD
rs774995569	p.Gly119Ser	missense variant	-	NC_000001.11:g.228050697G>A	ExAC,TOPMed,gnomAD
rs1402544448	p.Val120Met	missense variant	-	NC_000001.11:g.228050700G>A	gnomAD
COSM6061611	p.Ala121Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228050704C>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ala121Val	missense variant	-	NC_000001.11:g.228050704C>T	NCI-TCGA
rs1243774748	p.Val124Met	missense variant	-	NC_000001.11:g.228050712G>A	TOPMed
rs1417726750	p.Thr125Arg	missense variant	-	NC_000001.11:g.228050716C>G	gnomAD
rs773519307	p.Arg126Cys	missense variant	-	NC_000001.11:g.228050718C>T	NCI-TCGA
rs370854032	p.Arg126His	missense variant	-	NC_000001.11:g.228050719G>A	ESP,ExAC,TOPMed,gnomAD
rs773519307	p.Arg126Cys	missense variant	-	NC_000001.11:g.228050718C>T	ExAC,gnomAD
rs766639977	p.Ser127Leu	missense variant	-	NC_000001.11:g.228050722C>T	ExAC,TOPMed,gnomAD
rs1297226194	p.Cys128Arg	missense variant	-	NC_000001.11:g.228050724T>C	gnomAD
rs1343957348	p.Glu130Val	missense variant	-	NC_000001.11:g.228050731A>T	TOPMed
rs776863772	p.Thr132Met	missense variant	-	NC_000001.11:g.228050737C>T	NCI-TCGA
rs150424650	p.Thr132Ala	missense variant	-	NC_000001.11:g.228050736A>G	ESP,TOPMed
rs776863772	p.Thr132Lys	missense variant	-	NC_000001.11:g.228050737C>A	ExAC,TOPMed,gnomAD
rs776863772	p.Thr132Met	missense variant	-	NC_000001.11:g.228050737C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala133Val	missense variant	-	NC_000001.11:g.228050740C>T	NCI-TCGA
rs61743220	p.Ala134Thr	missense variant	-	NC_000001.11:g.228050742G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1259994744	p.Cys138Trp	missense variant	-	NC_000001.11:g.228050756C>G	gnomAD
rs149537631	p.Ser140Asn	missense variant	-	NC_000001.11:g.228050761G>A	ESP,ExAC,TOPMed,gnomAD
rs751360123	p.Arg141Cys	missense variant	-	NC_000001.11:g.228050763C>T	NCI-TCGA,NCI-TCGA Cosmic
rs751360123	p.Arg141Cys	missense variant	-	NC_000001.11:g.228050763C>T	ExAC,TOPMed,gnomAD
rs148616293	p.Arg141Leu	missense variant	-	NC_000001.11:g.228050764G>T	ESP,ExAC,TOPMed,gnomAD
rs148616293	p.Arg141Pro	missense variant	-	NC_000001.11:g.228050764G>C	ESP,ExAC,TOPMed,gnomAD
rs148616293	p.Arg141His	missense variant	-	NC_000001.11:g.228050764G>A	ESP,ExAC,TOPMed,gnomAD
rs1484378284	p.His142Asn	missense variant	-	NC_000001.11:g.228050766C>A	gnomAD
rs1478227750	p.Ser145Leu	missense variant	-	NC_000001.11:g.228050776C>T	gnomAD
rs956380865	p.Pro146Ala	missense variant	-	NC_000001.11:g.228050778C>G	TOPMed
rs988241577	p.Pro146Leu	missense variant	-	NC_000001.11:g.228050779C>T	TOPMed
rs1196429845	p.Gly147Asp	missense variant	-	NC_000001.11:g.228050782G>A	TOPMed,gnomAD
rs779484095	p.Lys148Met	missense variant	-	NC_000001.11:g.228050785A>T	ExAC
rs866676661	p.Lys148Asn	missense variant	-	NC_000001.11:g.228050786G>T	TOPMed
rs748823923	p.Lys151Arg	missense variant	-	NC_000001.11:g.228050794A>G	ExAC,gnomAD
rs772499033	p.Gly153Ser	missense variant	-	NC_000001.11:g.228050799G>A	ExAC,gnomAD
rs1021976426	p.Gly154Asp	missense variant	-	NC_000001.11:g.228050803G>A	TOPMed,gnomAD
rs1467269448	p.Ser156Arg	missense variant	-	NC_000001.11:g.228050810C>A	TOPMed,gnomAD
COSM5106771	p.Glu157Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228050813G>T	NCI-TCGA Cosmic
rs778326387	p.Glu157Lys	missense variant	-	NC_000001.11:g.228050811G>A	NCI-TCGA,NCI-TCGA Cosmic
rs778326387	p.Glu157Lys	missense variant	-	NC_000001.11:g.228050811G>A	ExAC,TOPMed,gnomAD
COSM4028840	p.Asp158Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228050815A>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Asp158His	missense variant	-	NC_000001.11:g.228050814G>C	NCI-TCGA
rs1488574529	p.Asp158Asn	missense variant	-	NC_000001.11:g.228050814G>A	NCI-TCGA
rs1291558728	p.Asp158Val	missense variant	-	NC_000001.11:g.228050815A>T	TOPMed
rs1488574529	p.Asp158Asn	missense variant	-	NC_000001.11:g.228050814G>A	TOPMed,gnomAD
rs375627842	p.Glu160Lys	missense variant	-	NC_000001.11:g.228050820G>A	NCI-TCGA
rs375627842	p.Glu160Lys	missense variant	-	NC_000001.11:g.228050820G>A	ESP,ExAC,TOPMed,gnomAD
rs375627842	p.Glu160Gln	missense variant	-	NC_000001.11:g.228050820G>C	ESP,ExAC,TOPMed,gnomAD
rs759770474	p.Gly163Arg	missense variant	-	NC_000001.11:g.228050829G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Met164Val	missense variant	-	NC_000001.11:g.228050832A>G	NCI-TCGA
rs1003822634	p.Met164Ile	missense variant	-	NC_000001.11:g.228050834G>A	TOPMed,gnomAD
rs1003822634	p.Met164Ile	missense variant	-	NC_000001.11:g.228050834G>C	TOPMed,gnomAD
rs1352751814	p.Val165Glu	missense variant	-	NC_000001.11:g.228050836T>A	TOPMed
rs529067103	p.Ser166Cys	missense variant	-	NC_000001.11:g.228050839C>G	ExAC,TOPMed,gnomAD
rs775470850	p.Arg167Trp	missense variant	-	NC_000001.11:g.228050841C>T	ExAC,TOPMed,gnomAD
rs1208275108	p.Arg167Gln	missense variant	-	NC_000001.11:g.228050842G>A	TOPMed,gnomAD
rs1279931043	p.Glu168Asp	missense variant	-	NC_000001.11:g.228050846G>C	gnomAD
NCI-TCGA novel	p.Phe169Leu	missense variant	-	NC_000001.11:g.228050847T>C	NCI-TCGA
rs141170201	p.Phe169Leu	missense variant	-	NC_000001.11:g.228050849C>A	ESP,ExAC,TOPMed,gnomAD
rs1218915358	p.Ala170Thr	missense variant	-	NC_000001.11:g.228050850G>A	TOPMed,gnomAD
rs1485828508	p.Asp171Asn	missense variant	-	NC_000001.11:g.228050853G>A	NCI-TCGA Cosmic
rs1485828508	p.Asp171Asn	missense variant	-	NC_000001.11:g.228050853G>A	TOPMed,gnomAD
rs61742275	p.Asp171Glu	missense variant	-	NC_000001.11:g.228050855C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs761771501	p.Ala172Thr	missense variant	-	NC_000001.11:g.228050856G>A	ExAC,TOPMed,gnomAD
rs761771501	p.Ala172Ser	missense variant	-	NC_000001.11:g.228050856G>T	ExAC,TOPMed,gnomAD
rs767429545	p.Arg173Trp	missense variant	-	NC_000001.11:g.228050859C>T	ExAC,TOPMed
rs750227757	p.Arg173Gln	missense variant	-	NC_000001.11:g.228050860G>A	ExAC,TOPMed,gnomAD
rs750227757	p.Arg173Leu	missense variant	-	NC_000001.11:g.228050860G>T	ExAC,TOPMed,gnomAD
rs755786376	p.Arg176Trp	missense variant	-	NC_000001.11:g.228050868C>T	ExAC,gnomAD
rs779729203	p.Arg176Gln	missense variant	-	NC_000001.11:g.228050869G>A	ExAC,TOPMed,gnomAD
rs1229666623	p.Pro177Leu	missense variant	-	NC_000001.11:g.228050872C>T	TOPMed
NCI-TCGA novel	p.Pro177Ser	missense variant	-	NC_000001.11:g.228050871C>T	NCI-TCGA
rs1343293977	p.Asp178Gly	missense variant	-	NC_000001.11:g.228050875A>G	gnomAD
NCI-TCGA novel	p.Ala179Val	missense variant	-	NC_000001.11:g.228050878C>T	NCI-TCGA
rs753339916	p.Ala179Gly	missense variant	-	NC_000001.11:g.228050878C>G	ExAC,gnomAD
COSM4899749	p.Arg180Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228050880C>T	NCI-TCGA Cosmic
rs147719804	p.Arg180His	missense variant	-	NC_000001.11:g.228050881G>A	ESP,ExAC,gnomAD
NCI-TCGA novel	p.Ala182Val	missense variant	-	NC_000001.11:g.228050887C>T	NCI-TCGA
rs1217311405	p.Asn184Ser	missense variant	-	NC_000001.11:g.228050893A>G	TOPMed,gnomAD
rs1217311405	p.Asn184Thr	missense variant	-	NC_000001.11:g.228050893A>C	TOPMed,gnomAD
rs778250375	p.Arg185Cys	missense variant	-	NC_000001.11:g.228050895C>T	NCI-TCGA
rs747520416	p.Arg185His	missense variant	-	NC_000001.11:g.228050896G>A	NCI-TCGA,NCI-TCGA Cosmic
rs747520416	p.Arg185His	missense variant	-	NC_000001.11:g.228050896G>A	ExAC,TOPMed,gnomAD
rs778250375	p.Arg185Cys	missense variant	-	NC_000001.11:g.228050895C>T	ExAC,gnomAD
rs771369579	p.Asn188Ser	missense variant	-	NC_000001.11:g.228050905A>G	ExAC,gnomAD
NCI-TCGA novel	p.Arg192Cys	missense variant	-	NC_000001.11:g.228050916C>T	NCI-TCGA
rs746228586	p.Arg192His	missense variant	-	NC_000001.11:g.228050917G>A	NCI-TCGA
rs746228586	p.Arg192His	missense variant	-	NC_000001.11:g.228050917G>A	ExAC,gnomAD
rs769957066	p.Gln193Ter	stop gained	-	NC_000001.11:g.228050919C>T	ExAC,gnomAD
COSM4028844	p.Ala196Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228058993C>T	NCI-TCGA Cosmic
rs913365692	p.Ala196Asp	missense variant	-	NC_000001.11:g.228058993C>A	gnomAD
NCI-TCGA novel	p.Ser197Thr	missense variant	-	NC_000001.11:g.228058996G>C	NCI-TCGA
rs1210134207	p.Met199Thr	missense variant	-	NC_000001.11:g.228059002T>C	TOPMed,gnomAD
rs752245358	p.Met199Leu	missense variant	-	NC_000001.11:g.228059001A>C	ExAC,gnomAD
rs757925292	p.His200Asn	missense variant	-	NC_000001.11:g.228059004C>A	ExAC,TOPMed,gnomAD
rs763552773	p.Leu201Pro	missense variant	-	NC_000001.11:g.228059008T>C	ExAC,gnomAD
NCI-TCGA novel	p.Cys205Tyr	missense variant	-	NC_000001.11:g.228059020G>A	NCI-TCGA
COSM1339435	p.Gly207Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228059025G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ser209Leu	missense variant	-	NC_000001.11:g.228059032C>T	NCI-TCGA
NCI-TCGA novel	p.Gly210Ser	missense variant	-	NC_000001.11:g.228059034G>A	NCI-TCGA
COSM5134716	p.Glu213Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228059045G>T	NCI-TCGA Cosmic
rs374568174	p.Glu213Lys	missense variant	-	NC_000001.11:g.228059043G>A	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Trp218Arg	missense variant	-	NC_000001.11:g.228059058T>A	NCI-TCGA
rs1478654890	p.Trp218Arg	missense variant	-	NC_000001.11:g.228059058T>C	gnomAD
rs756519375	p.Trp219Arg	missense variant	-	NC_000001.11:g.228059061T>C	ExAC,TOPMed,gnomAD
rs1415269833	p.Trp219Cys	missense variant	-	NC_000001.11:g.228059063G>T	gnomAD
rs780521544	p.Trp219Ser	missense variant	-	NC_000001.11:g.228059062G>C	ExAC,gnomAD
rs972949582	p.Pro222Thr	missense variant	-	NC_000001.11:g.228059070C>A	TOPMed
rs972949582	p.Pro222Ala	missense variant	-	NC_000001.11:g.228059070C>G	TOPMed
COSM464076	p.Asp223Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228059073G>T	NCI-TCGA Cosmic
rs749607111	p.Asp223His	missense variant	-	NC_000001.11:g.228059073G>C	ExAC,gnomAD
rs755288390	p.Asp223Gly	missense variant	-	NC_000001.11:g.228059074A>G	ExAC,TOPMed,gnomAD
rs779252848	p.Ala226Thr	missense variant	-	NC_000001.11:g.228059082G>A	ExAC,gnomAD
rs1306538398	p.Ile227Met	missense variant	-	NC_000001.11:g.228059087C>G	TOPMed
rs1279333399	p.Gly228Arg	missense variant	-	NC_000001.11:g.228059088G>C	TOPMed,gnomAD
rs1279333399	p.Gly228Ser	missense variant	-	NC_000001.11:g.228059088G>A	TOPMed,gnomAD
rs1279333399	p.Gly228Cys	missense variant	-	NC_000001.11:g.228059088G>T	TOPMed,gnomAD
rs528410256	p.Asp229Tyr	missense variant	-	NC_000001.11:g.228059091G>T	1000Genomes
rs918805028	p.Leu231Phe	missense variant	-	NC_000001.11:g.228059097C>T	TOPMed
rs540131703	p.Lys234Met	missense variant	-	NC_000001.11:g.228059107A>T	1000Genomes,gnomAD
rs748335041	p.Lys234Glu	missense variant	-	NC_000001.11:g.228059106A>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Tyr235Cys	missense variant	-	NC_000001.11:g.228059110A>G	NCI-TCGA
rs773363110	p.Asp236Gly	missense variant	-	NC_000001.11:g.228059113A>G	ExAC,gnomAD
rs772312947	p.Asp236Asn	missense variant	-	NC_000001.11:g.228059112G>A	ExAC,gnomAD
rs148923278	p.Ser237Arg	missense variant	-	NC_000001.11:g.228059115A>C	ESP,ExAC,TOPMed,gnomAD
rs148923278	p.Ser237Gly	missense variant	-	NC_000001.11:g.228059115A>G	ESP,ExAC,TOPMed,gnomAD
rs759222295	p.Ser239Leu	missense variant	-	NC_000001.11:g.228059122C>T	ExAC,gnomAD
rs1372749020	p.Met241Ile	missense variant	-	NC_000001.11:g.228059129G>T	TOPMed
rs1489235025	p.Arg247Trp	missense variant	-	NC_000001.11:g.228059145C>T	gnomAD
rs1425651353	p.Ser249Phe	missense variant	-	NC_000001.11:g.228059152C>T	TOPMed
NCI-TCGA novel	p.Arg250His	missense variant	-	NC_000001.11:g.228059155G>A	NCI-TCGA
rs1478273314	p.Trp252Leu	missense variant	-	NC_000001.11:g.228059161G>T	gnomAD
rs762526284	p.Val253Leu	missense variant	-	NC_000001.11:g.228059163G>C	ExAC,gnomAD
rs1393525016	p.Glu254Asp	missense variant	-	NC_000001.11:g.228059168G>T	gnomAD
rs1244824420	p.Thr255Ile	missense variant	-	NC_000001.11:g.228059170C>T	TOPMed,gnomAD
rs1434140543	p.Pro258Ser	missense variant	-	NC_000001.11:g.228059178C>T	gnomAD
rs763607191	p.Pro258Leu	missense variant	-	NC_000001.11:g.228059179C>T	ExAC,gnomAD
COSM4028846	p.Arg259Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228059181C>T	NCI-TCGA Cosmic
rs768601883	p.Arg259Leu	missense variant	-	NC_000001.11:g.228059182G>T	gnomAD
rs1318316656	p.Thr261Pro	missense variant	-	NC_000001.11:g.228059187A>C	gnomAD
rs761306494	p.Tyr262Ser	missense variant	-	NC_000001.11:g.228059191A>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe263Leu	missense variant	-	NC_000001.11:g.228059195C>A	NCI-TCGA
rs766763034	p.Lys264Met	missense variant	-	NC_000001.11:g.228059197A>T	ExAC,gnomAD
rs754274567	p.Val265Met	missense variant	-	NC_000001.11:g.228059199G>A	ExAC,gnomAD
rs755419088	p.Pro266Leu	missense variant	-	NC_000001.11:g.228059203C>T	ExAC,gnomAD
COSM4028848	p.Thr267Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228059206C>T	NCI-TCGA Cosmic
rs1286126766	p.Thr267Ala	missense variant	-	NC_000001.11:g.228059205A>G	gnomAD
rs1352290312	p.Thr267Lys	missense variant	-	NC_000001.11:g.228059206C>A	gnomAD
rs758639003	p.Glu268Asp	missense variant	-	NC_000001.11:g.228059210G>T	ExAC,gnomAD
rs1451915997	p.Arg269Ser	missense variant	-	NC_000001.11:g.228059211C>A	gnomAD
rs942761890	p.Asp270Asn	missense variant	-	NC_000001.11:g.228059214G>A	TOPMed,gnomAD
rs1200771051	p.Val272Ile	missense variant	-	NC_000001.11:g.228059220G>A	gnomAD
rs777968701	p.Tyr273Phe	missense variant	-	NC_000001.11:g.228059224A>T	ExAC,gnomAD
NCI-TCGA novel	p.Glu275Lys	missense variant	-	NC_000001.11:g.228059229G>A	NCI-TCGA
rs770943239	p.Ala276Asp	missense variant	-	NC_000001.11:g.228059233C>A	ExAC,TOPMed,gnomAD
COSM6124800	p.Ser277Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228059236C>T	NCI-TCGA Cosmic
rs1451769077	p.Pro278Ser	missense variant	-	NC_000001.11:g.228059238C>T	gnomAD
rs1158471028	p.Asn279Asp	missense variant	-	NC_000001.11:g.228059241A>G	gnomAD
rs1392112871	p.Glu282Lys	missense variant	-	NC_000001.11:g.228059250G>A	gnomAD
NCI-TCGA novel	p.Pro283Leu	missense variant	-	NC_000001.11:g.228059254C>T	NCI-TCGA
rs745763393	p.Asn284Thr	missense variant	-	NC_000001.11:g.228059257A>C	ExAC,gnomAD
rs1439692173	p.Pro285His	missense variant	-	NC_000001.11:g.228059260C>A	gnomAD
rs762651977	p.Phe290Ser	missense variant	-	NC_000001.11:g.228059275T>C	ExAC,TOPMed,gnomAD
rs890467543	p.Gly291Arg	missense variant	-	NC_000001.11:g.228059277G>C	TOPMed
COSM6045370	p.Arg293Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.228059283C>T	NCI-TCGA Cosmic
rs768290043	p.Arg293His	missense variant	-	NC_000001.11:g.228059284G>A	ExAC,gnomAD
rs1414615240	p.Asp294Tyr	missense variant	-	NC_000001.11:g.228059286G>T	gnomAD
rs1356967553	p.Arg295His	missense variant	-	NC_000001.11:g.228059290G>A	gnomAD
rs773948729	p.Thr296Pro	missense variant	-	NC_000001.11:g.228059292A>C	ExAC,TOPMed,gnomAD
rs1467916568	p.Thr296Ile	missense variant	-	NC_000001.11:g.228059293C>T	gnomAD
rs145403278	p.Val299Ile	missense variant	-	NC_000001.11:g.228059301G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1349702366	p.Val299Gly	missense variant	-	NC_000001.11:g.228059302T>G	gnomAD
rs1019954452	p.Ser300Asn	missense variant	-	NC_000001.11:g.228059305G>A	TOPMed,gnomAD
rs767000954	p.Ser300Arg	missense variant	-	NC_000001.11:g.228059306C>G	ExAC,gnomAD
rs1181222661	p.Ser301Ala	missense variant	-	NC_000001.11:g.228059307T>G	gnomAD
rs1181222661	p.Ser301Thr	missense variant	-	NC_000001.11:g.228059307T>A	gnomAD
rs760055965	p.His302Asp	missense variant	-	NC_000001.11:g.228059310C>G	ExAC,gnomAD
rs765713241	p.Gly303Ser	missense variant	-	NC_000001.11:g.228059313G>A	ExAC,gnomAD
rs1394201325	p.Ile304Val	missense variant	-	NC_000001.11:g.228059316A>G	TOPMed,gnomAD
rs1459640996	p.Gly306Arg	missense variant	-	NC_000001.11:g.228059322G>C	TOPMed
rs1331586023	p.Gly306Val	missense variant	-	NC_000001.11:g.228059323G>T	gnomAD
rs1398220132	p.Leu310Met	missense variant	-	NC_000001.11:g.228059334C>A	gnomAD
rs902409625	p.Gly313Arg	missense variant	-	NC_000001.11:g.228059343G>C	TOPMed,gnomAD
rs902409625	p.Gly313Ser	missense variant	-	NC_000001.11:g.228059343G>A	TOPMed,gnomAD
rs1235051533	p.Gly315Asp	missense variant	-	NC_000001.11:g.228059350G>A	gnomAD
rs1000804649	p.Ala318Pro	missense variant	-	NC_000001.11:g.228059358G>C	TOPMed,gnomAD
rs1267785518	p.Arg319Gln	missense variant	-	NC_000001.11:g.228059362G>A	TOPMed
rs1199059579	p.Glu321Gln	missense variant	-	NC_000001.11:g.228059367G>C	gnomAD
rs1211326543	p.Arg322Gln	missense variant	-	NC_000001.11:g.228059371G>A	TOPMed
rs1211326543	p.Arg322Gln	missense variant	-	NC_000001.11:g.228059371G>A	NCI-TCGA
rs1339111495	p.Arg322Gly	missense variant	-	NC_000001.11:g.228059370C>G	gnomAD
rs1253254692	p.Arg323His	missense variant	-	NC_000001.11:g.228059374G>A	gnomAD
rs199932668	p.Arg324Trp	missense variant	-	NC_000001.11:g.228059376C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs751711828	p.Arg324Gln	missense variant	-	NC_000001.11:g.228059377G>A	ExAC,TOPMed,gnomAD
rs199932668	p.Arg324Gly	missense variant	-	NC_000001.11:g.228059376C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs751711828	p.Arg324Leu	missense variant	-	NC_000001.11:g.228059377G>T	ExAC,TOPMed,gnomAD
rs751711828	p.Arg324Pro	missense variant	-	NC_000001.11:g.228059377G>C	ExAC,TOPMed,gnomAD
rs1476266555	p.Glu325Asp	missense variant	-	NC_000001.11:g.228059381G>T	TOPMed,gnomAD
rs757311204	p.Lys326Gln	missense variant	-	NC_000001.11:g.228059382A>C	ExAC,gnomAD
rs745818320	p.Arg328His	missense variant	-	NC_000001.11:g.228059389G>A	ExAC,TOPMed,gnomAD
rs781265731	p.Arg328Cys	missense variant	-	NC_000001.11:g.228059388C>T	ExAC,gnomAD
rs781265731	p.Arg328Gly	missense variant	-	NC_000001.11:g.228059388C>G	ExAC,gnomAD
rs1173276571	p.Cys329Arg	missense variant	-	NC_000001.11:g.228059391T>C	gnomAD
rs779887551	p.His332Leu	missense variant	-	NC_000001.11:g.228059401A>T	ExAC,TOPMed,gnomAD
rs779887551	p.His332Arg	missense variant	-	NC_000001.11:g.228059401A>G	ExAC,TOPMed,gnomAD
rs1297319205	p.Trp333Ter	stop gained	-	NC_000001.11:g.228059404G>A	gnomAD
rs749047485	p.Cys334Phe	missense variant	-	NC_000001.11:g.228059407G>T	ExAC
rs1457857286	p.Ser338Asn	missense variant	-	NC_000001.11:g.228059419G>A	TOPMed
rs761489951	p.Gln340Arg	missense variant	-	NC_000001.11:g.228059425A>G	ExAC,TOPMed,gnomAD
rs772794103	p.Glu341Gly	missense variant	-	NC_000001.11:g.228059428A>G	ExAC,TOPMed,gnomAD
rs771490465	p.Glu341Gln	missense variant	-	NC_000001.11:g.228059427G>C	ExAC,gnomAD
rs375339690	p.Val345Ile	missense variant	-	NC_000001.11:g.228059439G>A	NCI-TCGA
rs1257348180	p.Val345Ala	missense variant	-	NC_000001.11:g.228059440T>C	gnomAD
rs375339690	p.Val345Phe	missense variant	-	NC_000001.11:g.228059439G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs375339690	p.Val345Ile	missense variant	-	NC_000001.11:g.228059439G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1488910356	p.Asp347Glu	missense variant	-	NC_000001.11:g.228059447C>A	gnomAD
rs776037564	p.Val348Met	missense variant	-	NC_000001.11:g.228059448G>A	ExAC,gnomAD
rs776037564	p.Val348Leu	missense variant	-	NC_000001.11:g.228059448G>T	ExAC,gnomAD
rs1428330715	p.Thr350Ile	missense variant	-	NC_000001.11:g.228059455C>T	gnomAD
rs763389055	p.Lys352Arg	missense variant	-	NC_000001.11:g.228059461A>G	ExAC,TOPMed,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0002395	Alzheimer's Disease	disease	BEFREE
C0002793	Anaplasia	disease	BEFREE
C0003864	Arthritis	disease	BEFREE
C0004763	Barrett Esophagus	disease	BEFREE
C0005940	Bone Diseases	group	LHGDN
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0007102	Malignant tumor of colon	disease	BEFREE
C0007134	Renal Cell Carcinoma	disease	BEFREE
C0009402	Colorectal Carcinoma	disease	BEFREE
C0014175	Endometriosis	disease	BEFREE
C0016395	Focal Dermal Hypoplasia	disease	BEFREE
C0016655	Fractures, Multiple	group	HPO
C0017636	Glioblastoma	disease	BEFREE
C0017638	Glioma	disease	BEFREE
C0020676	Hypothyroidism	disease	RGD
C0023418	leukemia	disease	BEFREE
C0023449	Acute lymphocytic leukemia	disease	BEFREE
C0023895	Liver diseases	group	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0025202	melanoma	disease	BEFREE;LHGDN
C0026764	Multiple Myeloma	disease	BEFREE;LHGDN
C0027627	Neoplasm Metastasis	phenotype	BEFREE
C0027819	Neuroblastoma	group	BEFREE
C0028754	Obesity	disease	CTD_human
C0029456	Osteoporosis	disease	HPO
C0029925	Ovarian Carcinoma	disease	BEFREE
C0033578	Prostatic Neoplasms	group	LHGDN
C0035126	Reperfusion Injury	disease	CTD_human
C0035334	Retinitis Pigmentosa	disease	BEFREE
C0035412	Rhabdomyosarcoma	disease	BEFREE
C0151825	Bone pain	phenotype	HPO
C0178874	Tumor Progression	phenotype	BEFREE
C0220630	Adult Liver Carcinoma	disease	BEFREE
C0238790	bone destruction	disease	BEFREE
C0262431	Compression fracture of vertebral column	phenotype	HPO
C0264080	Juvenile osteoporosis	disease	ORPHANET
C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	disease	BEFREE
C0340970	Congenital neutropenia	disease	BEFREE
C0345904	Malignant neoplasm of liver	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0410550	Collapse of vertebra	disease	HPO
C0494165	Secondary malignant neoplasm of liver	disease	BEFREE
C0575081	Gait abnormality	group	HPO
C0600139	Prostate carcinoma	disease	BEFREE
C0677950	Stage IV Colorectal Cancer	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0684249	Carcinoma of lung	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0700095	Central neuroblastoma	disease	BEFREE
C0856169	Endothelial dysfunction	phenotype	BEFREE
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1168401	Squamous cell carcinoma of the head and neck	disease	BEFREE
C1378703	Renal carcinoma	disease	BEFREE
C1527249	Colorectal Cancer	disease	BEFREE
C1833752	Varying degree of multiple fractures	phenotype	HPO
C1853118	Severe congenital neutropenia	phenotype	BEFREE
C2239176	Liver carcinoma	disease	BEFREE
C2939420	Metastatic Neoplasm	phenotype	BEFREE
C2945695	Limb ischemia	disease	BEFREE
C3146251	Stage IV Colorectal Cancer AJCC v7	disease	BEFREE
C3539878	Triple Negative Breast Neoplasms	disease	BEFREE
C3642345	Luminal A Breast Carcinoma	disease	BEFREE
C3805574	Increased fracture rate	phenotype	HPO
C3806283	Frequent fractures	phenotype	HPO

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0003713	transcription coactivator activity	IEA
GO:0005102	signaling receptor binding	IPI
GO:0005109	frizzled binding	IBA
GO:0005515	protein binding	IPI
GO:0019904	protein domain specific binding	IEA
GO:0039706	co-receptor binding	IPI
GO:0048018	receptor ligand activity	IDA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001649	osteoblast differentiation	IEA
GO:0001701	in utero embryonic development	IEA
GO:0001819	positive regulation of cytokine production	IEA
GO:0001934	positive regulation of protein phosphorylation	IDA
GO:0001947	heart looping	IEA
GO:0002092	positive regulation of receptor internalization	IDA
GO:0003136	negative regulation of heart induction by canonical Wnt signaling pathway	IDA
GO:0007411	axon guidance	IEA
GO:0008283	cell population proliferation	IMP
GO:0008284	positive regulation of cell population proliferation	ISS
GO:0010387	COP9 signalosome assembly	ISS
GO:0010628	positive regulation of gene expression	IDA
GO:0010977	negative regulation of neuron projection development	ISS
GO:0016055	Wnt signaling pathway	IBA
GO:0016055	Wnt signaling pathway	TAS
GO:0021527	spinal cord association neuron differentiation	IEA
GO:0021766	hippocampus development	IEA
GO:0021846	cell proliferation in forebrain	ISS
GO:0021874	Wnt signaling pathway involved in forebrain neuroblast division	IEA
GO:0021904	dorsal/ventral neural tube patterning	IEA
GO:0030097	hemopoiesis	IEA
GO:0030182	neuron differentiation	ISS
GO:0030182	neuron differentiation	IBA
GO:0030198	extracellular matrix organization	IEA
GO:0030879	mammary gland development	IEA
GO:0030890	positive regulation of B cell proliferation	IEA
GO:0032092	positive regulation of protein binding	IDA
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA
GO:0033278	cell proliferation in midbrain	TAS
GO:0034613	cellular protein localization	IEA
GO:0035914	skeletal muscle cell differentiation	IEA
GO:0036342	post-anal tail morphogenesis	IEA
GO:0036465	synaptic vesicle recycling	TAS
GO:0042472	inner ear morphogenesis	IEA
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
GO:0045165	cell fate commitment	IBA
GO:0045599	negative regulation of fat cell differentiation	IEA
GO:0045893	positive regulation of transcription, DNA-templated	ISS
GO:0045944	positive regulation of transcription by RNA polymerase II	ISS
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
GO:0048337	positive regulation of mesodermal cell fate specification	IDA
GO:0048343	paraxial mesodermal cell fate commitment	IEA
GO:0048643	positive regulation of skeletal muscle tissue development	IEA
GO:0048697	positive regulation of collateral sprouting in absence of injury	IEA
GO:0048843	negative regulation of axon extension involved in axon guidance	IEA
GO:0050768	negative regulation of neurogenesis	ISS
GO:0050804	modulation of chemical synaptic transmission	IEA
GO:0050807	regulation of synapse organization	IDA
GO:0050807	regulation of synapse organization	IMP
GO:0051091	positive regulation of DNA-binding transcription factor activity	IEA
GO:0060070	canonical Wnt signaling pathway	IDA
GO:0060070	canonical Wnt signaling pathway	IMP
GO:0061098	positive regulation of protein tyrosine kinase activity	IEA
GO:0061184	positive regulation of dermatome development	IDA
GO:0061317	canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	IDA
GO:0062009	secondary palate development	IMP
GO:0070507	regulation of microtubule cytoskeleton organization	IEA
GO:0070527	platelet aggregation	IEA
GO:0071300	cellular response to retinoic acid	ISS
GO:0090245	axis elongation involved in somitogenesis	IEA
GO:0090263	positive regulation of canonical Wnt signaling pathway	IDA
GO:0090676	calcium ion transmembrane transport via low voltage-gated calcium channel	IEA
GO:0099054	presynapse assembly	TAS
GO:0099527	postsynapse to nucleus signaling pathway	IEA
GO:1901215	negative regulation of neuron death	IEA
GO:1903078	positive regulation of protein localization to plasma membrane	IEA
GO:1904339	negative regulation of dopaminergic neuron differentiation	IEA
GO:1904798	positive regulation of core promoter binding	IEA
GO:1904886	beta-catenin destruction complex disassembly	TAS
GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	TAS
GO:1905606	regulation of presynapse assembly	IDA
GO:1905606	regulation of presynapse assembly	IMP
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	IEA
GO:2000081	positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation	IEA
GO:2000179	positive regulation of neural precursor cell proliferation	IEA
GO:2000347	positive regulation of hepatocyte proliferation	IEA
GO:2000727	positive regulation of cardiac muscle cell differentiation	IDA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	ISS
GO:0005615	extracellular space	IBA
GO:0005615	extracellular space	IDA
GO:0005788	endoplasmic reticulum lumen	TAS
GO:0005796	Golgi lumen	TAS
GO:0005886	plasma membrane	TAS
GO:0009986	cell surface	ISS
GO:0030666	endocytic vesicle membrane	TAS
GO:0031901	early endosome membrane	TAS
GO:0070062	extracellular exosome	TAS
GO:0098793	presynapse	IEA
GO:0098978	glutamatergic synapse	IDA
GO:0098978	glutamatergic synapse	IMP
GO:1990851	Wnt-Frizzled-LRP5/6 complex	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	IEA
R-HSA-3238698	WNT ligand biogenesis and trafficking	TAS
R-HSA-3238698	WNT ligand biogenesis and trafficking	IEA
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-373080	Class B/2 (Secretin family receptors)	IEA
R-HSA-3772470	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	IEA
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	TAS
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	IEA
R-HSA-4641263	Regulation of FZD by ubiquitination	TAS
R-HSA-4791275	Signaling by WNT in cancer	TAS
R-HSA-500792	GPCR ligand binding	IEA
R-HSA-5340588	RNF mutants show enhanced WNT signaling and proliferation	TAS
R-HSA-5663202	Diseases of signal transduction	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C016780	11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid	[Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of WNT3A gene	30521419
C097949	1,25-dihydroxyvitamin D	[Dexamethasone co-treated with 1,25-dihydroxyvitamin D] inhibits the reaction [WNT3A protein results in increased expression of ALPL protein]	15270777
D015056	1-Methyl-3-isobutylxanthine	APCDD1 protein promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT3A protein]	28242765
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT3A mRNA	28242765
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [WNT3A results in increased expression of AXIN2 protein]	19464575
C417520	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione co-treated with WNT3A protein] results in increased expression of CCND1 mRNA	25381574
C417520	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	WNT3A protein promotes the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]	25381574
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of WNT3A mRNA	16788091
C542472	4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid	4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid inhibits the reaction [Valproic Acid results in increased expression of WNT3A mRNA]	27693483
C493177	4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide	4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [WNT3A protein results in increased phosphorylation of LRP6 protein]	21602191
C552996	4-aminoethylamino-emodin	[4-aminoethylamino-emodin co-treated with WNT3A protein] results in decreased expression of GYS1 protein modified form	19228266
C573233	5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one	5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one affects the expression of WNT3A mRNA	24646949
C060298	5,7-dimethoxyflavone	5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of WNT3A protein]	21554863
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in decreased expression of WNT3A mRNA]	29990529
D000077410	Aluminum Chloride	Aluminum Chloride results in decreased expression of WNT3A mRNA	26474975
D000077410	Aluminum Chloride	Aluminum Chloride results in decreased expression of WNT3A protein	26474975
D016590	Aphidicolin	Aphidicolin results in decreased expression of WNT3A mRNA	29990529
D001151	Arsenic	Arsenic results in increased expression of WNT3A mRNA	23108036
D001151	Arsenic	Arsenic results in increased expression of WNT3A protein	23108036
C487081	belinostat	belinostat results in increased expression of WNT3A mRNA	23671600
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of WNT3A mRNA	30951980
C006780	bisphenol A	bisphenol A affects the expression of WNT3A mRNA	22574217
C006780	bisphenol A	bisphenol A results in decreased expression of WNT3A mRNA	30951980
C006780	bisphenol A	bisphenol A inhibits the reaction [WNT3A protein results in increased expression of CCND1 mRNA]	25381574
C006780	bisphenol A	bisphenol A inhibits the reaction [WNT3A protein results in increased expression of LEF1 mRNA]	25381574
C006780	bisphenol A	bisphenol A results in decreased expression of WNT3A mRNA	25181051
C006780	bisphenol A	WNT3A protein affects the reaction [bisphenol A results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]	25381574
C006780	bisphenol A	WNT3A protein affects the reaction [bisphenol A results in increased expression of and results in decreased phosphorylation of GSK3B protein]	25381574
C000611646	bisphenol F	bisphenol F results in decreased expression of WNT3A mRNA	30951980
C584509	C646 compound	C646 compound results in decreased activity of WNT3A protein	26921506
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of WNT3A mRNA	20478370
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of WNT3A promoter	22457795
D002186	Cannabinoids	[Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of WNT3A gene	30521419
D002737	Chloroprene	Chloroprene results in decreased expression of WNT3A mRNA	23125180
D003471	Cuprizone	Cuprizone results in decreased expression of WNT3A mRNA	26577399
D000077209	Decitabine	Decitabine results in increased expression of WNT3A mRNA	27915011
C107676	deguelin	deguelin results in decreased expression of WNT3A mRNA	19861542
D003907	Dexamethasone	APCDD1 protein promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT3A protein]	28242765
D003907	Dexamethasone	[Dexamethasone co-treated with 1,25-dihydroxyvitamin D] inhibits the reaction [WNT3A protein results in increased expression of ALPL protein]	15270777
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT3A mRNA	28242765
D003976	Diazinon	Diazinon affects the expression of WNT3A mRNA	19130878
D004008	Diclofenac	Diclofenac results in decreased expression of WNT3A mRNA	24788080
D004026	Dieldrin	Dieldrin affects the expression of WNT3A mRNA	19130878
D004041	Dietary Fats	Dietary Fats results in increased expression of WNT3A protein	28242765
D004052	Diethylnitrosamine	5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of WNT3A protein]	21554863
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of WNT3A protein	21554863
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of WNT3A mRNA	29990529
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in decreased expression of WNT3A mRNA	30165855
D000431	Ethanol	[WNT3A protein co-treated with Ethanol] results in increased activity of GPT protein	30976847
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of WNT3A mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WNT3A mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of WNT3A mRNA	23550701
C098546	ethyl tert-butyl ether	ethyl tert-butyl ether results in decreased expression of WNT3A mRNA	22609741
D005047	Etoposide	WNT3A protein results in increased susceptibility to Etoposide	19864107
C575430	FH535	FH535 inhibits the reaction [WNT3A protein results in increased expression of CCND1 mRNA]	25381574
C575430	FH535	FH535 inhibits the reaction [WNT3A protein results in increased expression of LEF1 mRNA]	25381574
C575430	FH535	WNT3A protein promotes the reaction [FH535 results in decreased expression of LEF1 mRNA]	25381574
D005473	Fluoxetine	Fluoxetine affects the expression of WNT3A mRNA	29893963
D005473	Fluoxetine	Fluoxetine results in increased phosphorylation of WNT3A protein	21048974
D005492	Folic Acid	[Folic Acid co-treated with sodium arsenite] results in increased methylation of WNT3A mRNA	22959928
D005492	Folic Acid	Folic Acid results in increased methylation of WNT3A mRNA	22959928
D005947	Glucose	Glucose results in decreased expression of WNT3A	24882757
D005947	Glucose	Glucose results in decreased expression of WNT3A mRNA	21818840
D006118	Griseofulvin	Griseofulvin affects the expression of WNT3A mRNA	12735108
D006247	Harmine	Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]	20519739
D006247	Harmine	Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA]	20519739
D006582	Hexachlorophene	Hexachlorophene inhibits the reaction [WNT3A protein results in increased expression of CTNNB1 protein]	16735606
D006918	Hydroxyurea	Hydroxyurea results in decreased expression of WNT3A mRNA	29990529
C499403	icaritin	icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA]	30731080
C499403	icaritin	icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein]	30731080
C499403	icaritin	icaritin results in increased expression of WNT3A mRNA	30731080
C499403	icaritin	icaritin results in increased expression of WNT3A protein	30731080
C082359	imidacloprid	imidacloprid results in increased expression of WNT3A mRNA	27792329
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of WNT3A mRNA	21396975
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of WNT3A mRNA	26752646
D007854	Lead	icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA]	30731080
D007854	Lead	icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein]	30731080
D007854	Lead	[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA	30731080
D007854	Lead	[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein	30731080
C017461	lead nitrate	icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA]	30731080
C017461	lead nitrate	icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein]	30731080
C017461	lead nitrate	[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA	30731080
C017461	lead nitrate	[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein	30731080
C034244	matrine	matrine results in decreased expression of WNT3A protein	31112718
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of WNT3A mRNA	26011545
D009532	Nickel	Nickel affects the expression of WNT3A mRNA	19130878
D009534	Niclosamide	Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]	27492973
D009534	Niclosamide	Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]	27492973
D009534	Niclosamide	Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]	19772353
D009534	Niclosamide	Niclosamide results in decreased expression of WNT3A mRNA	22576131
C522862	NT020 formula	NT020 formula results in decreased expression of WNT3A mRNA	26376629
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of WNT3A mRNA	27181905
C023036	perfluorooctanoic acid	WNT3A protein inhibits the reaction [perfluorooctanoic acid results in decreased expression of CDH1 protein]	23978332
C023036	perfluorooctanoic acid	WNT3A protein inhibits the reaction [perfluorooctanoic acid results in decreased expression of CTNNB1 protein]	23978332
C023036	perfluorooctanoic acid	WNT3A protein results in decreased susceptibility to perfluorooctanoic acid	23978332
D000077185	Resveratrol	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in decreased expression of WNT3A mRNA]	29990529
D000077185	Resveratrol	Resveratrol inhibits the reaction [WNT3A protein promotes the reaction [TCF4 protein binds to CTNNB1 protein]]	22935447
D000077185	Resveratrol	Resveratrol results in decreased expression of WNT3A mRNA	29990529
D000077185	Resveratrol	Resveratrol inhibits the reaction [DKK1 protein inhibits the reaction [WNT3A protein results in increased expression of CTNNB1]]	19665018
D000077185	Resveratrol	Resveratrol inhibits the reaction [DKK1 protein results in decreased activity of WNT3A protein]	19665018
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of WNT3A mRNA	21427059
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of WNT3A mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of WNT3A mRNA	27095093
C017947	sodium arsenite	[Folic Acid co-treated with sodium arsenite] results in increased methylation of WNT3A mRNA	22959928
D053260	Soot	Soot results in increased expression of WNT3A mRNA	26551751
C096680	tertiary-amyl methyl ether	tertiary-amyl methyl ether results in decreased expression of WNT3A mRNA	22609741
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WNT3A mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased secretion of WNT3A protein	26572662
D013749	Tetrachlorodibenzodioxin	WNT3A protein inhibits the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of KRT19 mRNA]	21602191
D013749	Tetrachlorodibenzodioxin	WNT3A protein promotes the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of CTNNB1 protein]	21602191
D013749	Tetrachlorodibenzodioxin	WNT3A protein promotes the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of CTNNB1 protein modified form]	21602191
D013749	Tetrachlorodibenzodioxin	WNT3A protein promotes the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]	21602191
D013749	Tetrachlorodibenzodioxin	WNT3A protein promotes the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein]	21602191
D013749	Tetrachlorodibenzodioxin	WNT3A protein promotes the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA]	21602191
D013749	Tetrachlorodibenzodioxin	WNT3A protein promotes the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 protein]	21602191
D013749	Tetrachlorodibenzodioxin	WNT3A protein promotes the reaction [[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]	21498875
D013749	Tetrachlorodibenzodioxin	WNT3A protein results in increased susceptibility to Tetrachlorodibenzodioxin	21498875
D017392	Thiobarbituric Acid Reactive Substances	WNT3A protein results in decreased abundance of Thiobarbituric Acid Reactive Substances	23875703
D014212	Tretinoin	CYP26A1 protein inhibits the reaction [Tretinoin results in decreased expression of WNT3A mRNA]	12588859
D014212	Tretinoin	Tretinoin results in decreased expression of WNT3A mRNA	12588859
D014501	Uranium	Uranium results in decreased expression of WNT3A mRNA	27639536
D014635	Valproic Acid	4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid inhibits the reaction [Valproic Acid results in increased expression of WNT3A mRNA]	27693483
D014635	Valproic Acid	Valproic Acid results in increased expression of WNT3A mRNA	19136453; 21427059; 27693483;

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-0217	Developmental protein
KW-1015	Disulfide bond
KW-0272	Extracellular matrix
KW-0325	Glycoprotein
KW-0449	Lipoprotein
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal
KW-0879	Wnt signaling pathway

Interpro

InterPro ID	InterPro Term
IPR005817	Wnt
IPR009141	Wnt3
IPR043158	Wnt_C
IPR018161	Wnt_CS

PROSITE

PROSITE ID	PROSITE Term
PS00246	WNT1

Pfam

Pfam ID	Pfam Term
PF00110	wnt

Gene: WNT3A

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Identified variants/mutations related to cleft phenotype

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction