CleftGeneDB-Search

Gene: DCAF7

Basic information

Tag	Content
Uniprot ID	P61962; B4E039; D3DU14; O15491; Q9DAE4;
Entrez ID	10238
Genbank protein ID	AAC18913.1; BAG64301.1; EAW94305.1; EAW94306.1; AAH01264.1;
Genbank nucleotide ID	NM_005828.4
Ensembl protein ID	ENSP00000402312; ENSP00000483236; ENSP00000403920;
Ensembl nucleotide ID	ENSG00000136485
Gene name	DDB1- and CUL4-associated factor 7
Gene symbol	DCAF7
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Manually collected
Reference	27033726
Functional description	Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Sequence	MSLHGKRKEI YKYEAPWTVY AMNWSVRPDK RFRLALGSFV EEYNNKVQLV GLDEESSEFI 60 CRNTFDHPYP TTKLMWIPDT KGVYPDLLAT SGDYLRVWRV GETETRLECL LNNNKNSDFC 120 APLTSFDWNE VDPYLLGTSS IDTTCTIWGL ETGQVLGRVN LVSGHVKTQL IAHDKEVYDI 180 AFSRAGGGRD MFASVGADGS VRMFDLRHLE HSTIIYEDPQ HHPLLRLCWN KQDPNYLATM 240 AMDGMEVVIL DVRVPCTPVA RLNNHRACVN GIAWAPHSSC HICTAADDHQ ALIWDIQQMP 300 RAIEDPILAY TAEGEINNVQ WASTQPDWIA ICYNNCLEIL RV 342

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Species	Evidence	Details
1:1 ortholog	DCAF7	516678	Q32L87	Bos taurus	Prediction	More>>
1:1 ortholog	DCAF7	100856670	E2REP1	Canis lupus familiaris	Prediction	More>>
1:1 ortholog	DCAF7	102172756	A0A452DQT9	Capra hircus	Prediction	More>>
1:1 ortholog	DCAF7	10238	P61962	Homo sapiens	Publication	More>>
1:1 ortholog	Dcaf7	71833	P61963	Mus musculus	Prediction	More>>
1:1 ortholog	DCAF7	454780	K7B4V7	Pan troglodytes	Prediction	More>>
1:1 ortholog	DCAF7	100347842	G1TAE4	Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Dcaf7	303602	B2RZ68	Rattus norvegicus	Prediction	More>>
1:1 ortholog	dcaf7	337565	Q7T3E0	Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs768561024	p.Lys6Arg	missense variant	-	NC_000017.11:g.63550694A>G	ExAC,gnomAD
rs1479094740	p.Pro16Leu	missense variant	-	NC_000017.11:g.63550724C>T	gnomAD
rs772876029	p.Pro16Ser	missense variant	-	NC_000017.11:g.63550723C>T	ExAC,TOPMed,gnomAD
rs1464847698	p.Thr18Ala	missense variant	-	NC_000017.11:g.63550729A>G	gnomAD
NCI-TCGA novel	p.Thr18Pro	missense variant	-	NC_000017.11:g.63550729A>C	NCI-TCGA
NCI-TCGA novel	p.Ala21Val	missense variant	-	NC_000017.11:g.63550739C>T	NCI-TCGA
NCI-TCGA novel	p.Asn23Tyr	missense variant	-	NC_000017.11:g.63550744A>T	NCI-TCGA
NCI-TCGA novel	p.Trp24Cys	missense variant	-	NC_000017.11:g.63550749G>C	NCI-TCGA
NCI-TCGA novel	p.Trp24Leu	missense variant	-	NC_000017.11:g.63550748G>T	NCI-TCGA
rs199661608	p.Ser25Gly	missense variant	-	NC_000017.11:g.63550750A>G	ESP,ExAC,gnomAD
NCI-TCGA novel	p.Arg27Trp	missense variant	-	NC_000017.11:g.63550756C>T	NCI-TCGA
NCI-TCGA novel	p.Lys30Arg	missense variant	-	NC_000017.11:g.63550766A>G	NCI-TCGA
NCI-TCGA novel	p.Lys30Ter	stop gained	-	NC_000017.11:g.63550765A>T	NCI-TCGA
rs189209549	p.Lys30Asn	missense variant	-	NC_000017.11:g.63550767G>T	1000Genomes
rs897241140	p.Ala35Val	missense variant	-	NC_000017.11:g.63550781C>T	TOPMed
NCI-TCGA novel	p.Ser38Gly	missense variant	-	NC_000017.11:g.63550789A>G	NCI-TCGA
rs767941373	p.Val40Met	missense variant	-	NC_000017.11:g.63550795G>A	ExAC,gnomAD
NCI-TCGA novel	p.Tyr43Cys	missense variant	-	NC_000017.11:g.63550805A>G	NCI-TCGA
NCI-TCGA novel	p.Asn45Ser	missense variant	-	NC_000017.11:g.63550811A>G	NCI-TCGA
NCI-TCGA novel	p.Val47Ala	missense variant	-	NC_000017.11:g.63578471T>C	NCI-TCGA
rs571745269	p.Val50Ile	missense variant	-	NC_000017.11:g.63578479G>A	1000Genomes,ExAC,gnomAD
rs760995880	p.Asp53Gly	missense variant	-	NC_000017.11:g.63578489A>G	ExAC,gnomAD
rs1175281235	p.Ser56Gly	missense variant	-	NC_000017.11:g.63578497A>G	gnomAD
rs1454397308	p.Glu58Gly	missense variant	-	NC_000017.11:g.63578504A>G	TOPMed,gnomAD
rs992575433	p.Thr64Ser	missense variant	-	NC_000017.11:g.63578522C>G	TOPMed
rs1290747077	p.Phe65Val	missense variant	-	NC_000017.11:g.63578524T>G	gnomAD
rs754408924	p.His67Gln	missense variant	-	NC_000017.11:g.63578532C>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro70Thr	missense variant	-	NC_000017.11:g.63578539C>A	NCI-TCGA
rs1347783127	p.Gly82Asp	missense variant	-	NC_000017.11:g.63578576G>A	gnomAD
rs950826751	p.Val83Asp	missense variant	-	NC_000017.11:g.63578579T>A	TOPMed
rs1301213649	p.Val83Ile	missense variant	-	NC_000017.11:g.63578578G>A	gnomAD
rs750400387	p.Tyr84Cys	missense variant	-	NC_000017.11:g.63578582A>G	ExAC,gnomAD
NCI-TCGA novel	p.Asp86Tyr	missense variant	-	NC_000017.11:g.63578587G>T	NCI-TCGA
rs1352316406	p.Ala89Ser	missense variant	-	NC_000017.11:g.63578596G>T	gnomAD
rs1267712031	p.Thr90Ala	missense variant	-	NC_000017.11:g.63578599A>G	TOPMed
rs909429261	p.Arg96His	missense variant	-	NC_000017.11:g.63578618G>A	TOPMed,gnomAD
NCI-TCGA novel	p.Val100Ala	missense variant	-	NC_000017.11:g.63579338T>C	NCI-TCGA
rs1184243532	p.Gly101Val	missense variant	-	NC_000017.11:g.63579341G>T	gnomAD
rs1213221378	p.Thr105Asn	missense variant	-	NC_000017.11:g.63579353C>A	TOPMed
rs1403862974	p.Leu111Pro	missense variant	-	NC_000017.11:g.63579371T>C	gnomAD
NCI-TCGA novel	p.Asn114Ser	missense variant	-	NC_000017.11:g.63579380A>G	NCI-TCGA
NCI-TCGA novel	p.Trp128Leu	missense variant	-	NC_000017.11:g.63579422G>T	NCI-TCGA
NCI-TCGA novel	p.Trp128Arg	missense variant	-	NC_000017.11:g.63579421T>C	NCI-TCGA
rs1452776427	p.Pro133Ser	missense variant	-	NC_000017.11:g.63579436C>T	gnomAD
NCI-TCGA novel	p.Leu150TrpPheSerTerUnk	frameshift	-	NC_000017.11:g.63579858G>-	NCI-TCGA
rs778766031	p.Val155Met	missense variant	-	NC_000017.11:g.63579878G>A	ExAC,gnomAD
rs372129328	p.Leu156Ser	missense variant	-	NC_000017.11:g.63579882T>C	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg158Ter	stop gained	-	NC_000017.11:g.63579887C>T	NCI-TCGA
rs746481906	p.Val162Met	missense variant	-	NC_000017.11:g.63579899G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gly164Asp	missense variant	-	NC_000017.11:g.63579906G>A	NCI-TCGA
rs1348148386	p.Lys175Arg	missense variant	-	NC_000017.11:g.63579939A>G	TOPMed
NCI-TCGA novel	p.Tyr178His	missense variant	-	NC_000017.11:g.63583505T>C	NCI-TCGA
rs1317199627	p.Ala181Thr	missense variant	-	NC_000017.11:g.63583514G>A	TOPMed
rs769425548	p.Arg184Gln	missense variant	-	NC_000017.11:g.63583524G>A	ExAC,gnomAD
rs1238032182	p.Arg184Trp	missense variant	-	NC_000017.11:g.63583523C>T	gnomAD
rs1359636592	p.Gly186Arg	missense variant	-	NC_000017.11:g.63583529G>A	gnomAD
rs1222461603	p.Gly187Arg	missense variant	-	NC_000017.11:g.63583532G>C	TOPMed
rs1441268776	p.Met191Ile	missense variant	-	NC_000017.11:g.63583546G>A	gnomAD
rs771179636	p.Val195Ala	missense variant	-	NC_000017.11:g.63583557T>C	ExAC,gnomAD
NCI-TCGA novel	p.Ser200Leu	missense variant	-	NC_000017.11:g.63583572C>T	NCI-TCGA
NCI-TCGA novel	p.Arg202Gln	missense variant	-	NC_000017.11:g.63583578G>A	NCI-TCGA
NCI-TCGA novel	p.Arg202Leu	missense variant	-	NC_000017.11:g.63583578G>T	NCI-TCGA
rs373483895	p.Arg202Trp	missense variant	-	NC_000017.11:g.63583577C>T	ESP,ExAC,TOPMed,gnomAD
rs1473585777	p.Arg207Cys	missense variant	-	NC_000017.11:g.63583592C>T	gnomAD
rs775653005	p.Arg207His	missense variant	-	NC_000017.11:g.63583593G>A	ExAC,gnomAD
rs1333344740	p.Ile214Val	missense variant	-	NC_000017.11:g.63583613A>G	gnomAD
NCI-TCGA novel	p.Tyr216ArgPheSerTerUnkUnk	frameshift	-	NC_000017.11:g.63583617_63583618TT>-	NCI-TCGA
NCI-TCGA novel	p.Glu217Lys	missense variant	-	NC_000017.11:g.63583622G>A	NCI-TCGA
rs376094329	p.Pro219Ala	missense variant	-	NC_000017.11:g.63583628C>G	ESP,ExAC,TOPMed,gnomAD
rs762853328	p.Arg226His	missense variant	-	NC_000017.11:g.63583650G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg226Cys	missense variant	-	NC_000017.11:g.63583649C>T	NCI-TCGA
rs1160993626	p.Cys228Ter	stop gained	-	NC_000017.11:g.63583657C>A	TOPMed
NCI-TCGA novel	p.Trp229Cys	missense variant	-	NC_000017.11:g.63583660G>C	NCI-TCGA
rs1417103898	p.Lys231Asn	missense variant	-	NC_000017.11:g.63583666G>C	TOPMed
NCI-TCGA novel	p.Pro234His	missense variant	-	NC_000017.11:g.63583674C>A	NCI-TCGA
rs754893586	p.Ala238Ser	missense variant	-	NC_000017.11:g.63583685G>T	ExAC,gnomAD
NCI-TCGA novel	p.Ala238Val	missense variant	-	NC_000017.11:g.63583686C>T	NCI-TCGA
rs1240338015	p.Thr239Ile	missense variant	-	NC_000017.11:g.63583689C>T	TOPMed,gnomAD
NCI-TCGA novel	p.Ala241Val	missense variant	-	NC_000017.11:g.63583695C>T	NCI-TCGA
NCI-TCGA novel	p.Asp243Asn	missense variant	-	NC_000017.11:g.63583700G>A	NCI-TCGA
NCI-TCGA novel	p.Glu246Lys	missense variant	-	NC_000017.11:g.63583709G>A	NCI-TCGA
NCI-TCGA novel	p.Asp251His	missense variant	-	NC_000017.11:g.63585223G>C	NCI-TCGA
rs925624922	p.Val252Ile	missense variant	-	NC_000017.11:g.63585226G>A	TOPMed
NCI-TCGA novel	p.Val259Ile	missense variant	-	NC_000017.11:g.63585247G>A	NCI-TCGA
NCI-TCGA novel	p.Ala260Thr	missense variant	-	NC_000017.11:g.63585250G>A	NCI-TCGA
NCI-TCGA novel	p.Asn264Ser	missense variant	-	NC_000017.11:g.63585263A>G	NCI-TCGA
rs1479068747	p.Arg266Ter	stop gained	-	NC_000017.11:g.63585268C>T	TOPMed,gnomAD
NCI-TCGA novel	p.Arg266Gln	missense variant	-	NC_000017.11:g.63585269G>A	NCI-TCGA
rs1401522873	p.Arg266Pro	missense variant	-	NC_000017.11:g.63585269G>C	gnomAD
rs1425855323	p.Cys268Arg	missense variant	-	NC_000017.11:g.63585274T>C	gnomAD
rs746192971	p.Val269Ile	missense variant	-	NC_000017.11:g.63585277G>A	ExAC,gnomAD
NCI-TCGA novel	p.Val269Ala	missense variant	-	NC_000017.11:g.63585278T>C	NCI-TCGA
rs758995656	p.Asn270Ser	missense variant	-	NC_000017.11:g.63585281A>G	ExAC,gnomAD
rs78760999	p.Ser279Pro	missense variant	-	NC_000017.11:g.63585307T>C	ExAC,gnomAD
rs1274925480	p.Ala286Val	missense variant	-	NC_000017.11:g.63589000C>T	gnomAD
NCI-TCGA novel	p.His289Tyr	missense variant	-	NC_000017.11:g.63589008C>T	NCI-TCGA
rs771961083	p.Gln290Arg	missense variant	-	NC_000017.11:g.63589012A>G	ExAC,gnomAD
rs1157190737	p.Arg301Gly	missense variant	-	NC_000017.11:g.63589044C>G	gnomAD
rs768436828	p.Arg301Gln	missense variant	-	NC_000017.11:g.63589045G>A	ExAC,gnomAD
rs761458805	p.Thr311Ala	missense variant	-	NC_000017.11:g.63589074A>G	ExAC,gnomAD
rs761458805	p.Thr311Ser	missense variant	-	NC_000017.11:g.63589074A>T	ExAC,gnomAD
rs764808179	p.Asn317Ser	missense variant	-	NC_000017.11:g.63589093A>G	ExAC,gnomAD
NCI-TCGA novel	p.Ala330Thr	missense variant	-	NC_000017.11:g.63589131G>A	NCI-TCGA
NCI-TCGA novel	p.Ile331Met	missense variant	-	NC_000017.11:g.63589136C>G	NCI-TCGA
rs1459054523	p.Cys332Phe	missense variant	-	NC_000017.11:g.63589138G>T	gnomAD
NCI-TCGA novel	p.Cys336Phe	missense variant	-	NC_000017.11:g.63589150G>T	NCI-TCGA
NCI-TCGA novel	p.Leu337Pro	missense variant	-	NC_000017.11:g.63589153T>C	NCI-TCGA

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0002871	Anemia	disease	BEFREE
C0002985	Angiokeratoma	disease	BEFREE
C0003469	Anxiety Disorders	group	BEFREE
C0007570	Celiac Disease	disease	BEFREE
C0007785	Cerebral Infarction	disease	BEFREE
C0011849	Diabetes Mellitus	group	BEFREE
C0014522	Epidermodysplasia Verruciformis	disease	BEFREE
C0023380	Lethargy	phenotype	BEFREE
C0026847	Spinal Muscular Atrophy	disease	BEFREE
C0030293	Pancreatic Insufficiency	disease	BEFREE
C0031511	Pheochromocytoma	disease	BEFREE
C0033975	Psychotic Disorders	group	BEFREE
C0036341	Schizophrenia	disease	BEFREE
C0036572	Seizures	phenotype	BEFREE
C0041107	Trisomy	group	BEFREE
C0042963	Vomiting	phenotype	BEFREE
C0149871	Deep Vein Thrombosis	disease	BEFREE
C0151786	Muscle Weakness	phenotype	BEFREE
C0221357	Brachydactyly	disease	BEFREE
C0242526	Gonadal Dysgenesis, 45,X	disease	BEFREE
C0267375	Chronic colitis	disease	BEFREE
C0267963	Exocrine pancreatic insufficiency	disease	BEFREE
C0346153	Breast Cancer, Familial	disease	BEFREE
C0349204	Nonorganic psychosis	disease	BEFREE
C0376634	Craniofacial Abnormalities	group	CTD_human
C0424605	Developmental delay (disorder)	disease	BEFREE
C0428908	Sinus Node Dysfunction (disorder)	disease	BEFREE
C0557874	Global developmental delay	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0876991	Histiocytosis haematophagic	disease	BEFREE
C1541923	Infective endocarditis	disease	BEFREE
C1838539	CARDIOMYOPATHY, FAMILIAL, WITH CONDUCTION DISTURBANCE	disease	BEFREE
C1860789	Leukemia, Megakaryoblastic, of Down Syndrome	disease	CTD_human
C3711376	Isodicentric Chromosome 15 Syndrome	disease	BEFREE
C4048158	Convulsions	phenotype	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005515	protein binding	IPI

GO:Biological Process

GO ID	GO Term	Evidence
GO:0007275	multicellular organism development	IEA
GO:0016567	protein ubiquitination	IEA
GO:0043687	post-translational protein modification	TAS

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005634	nucleus	IBA
GO:0005654	nucleoplasm	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	TAS
GO:0005829	cytosol	IDA
GO:0016363	nuclear matrix	IDA
GO:0016604	nuclear body	IDA
GO:0032991	protein-containing complex	IDA
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-390466	Chaperonin-mediated protein folding	IEA
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	IEA
R-HSA-391251	Protein folding	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8951664	Neddylation	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DCAF7 mRNA	19114083
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene affects the expression of DCAF7 mRNA	21346803
C533410	2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one	2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one affects the expression of DCAF7 mRNA	19946333
C533410	2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one	TP53 protein affects the reaction [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one affects the expression of DCAF7 mRNA]	19946333
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCAF7 mRNA	27188386
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DCAF7 mRNA	20018196
D000082	Acetaminophen	Acetaminophen affects the expression of DCAF7 mRNA	17562736
D020106	Acrylamide	Acrylamide affects the expression of DCAF7 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of DCAF7 mRNA	19770486
D000395	Air Pollutants, Occupational	Air Pollutants, Occupational results in decreased expression of DCAF7 mRNA	23195993
D001151	Arsenic	Arsenic affects the expression of DCAF7 mRNA	18414638
D001151	Arsenic	Arsenic affects the methylation of DCAF7 gene	25304211
C487081	belinostat	belinostat results in increased expression of DCAF7 mRNA	27188386
C044887	beta-methylcholine	beta-methylcholine affects the expression of DCAF7 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of DCAF7 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of DCAF7 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of DCAF7 gene	28505145
C584509	C646 compound	C646 compound results in decreased expression of DCAF7 mRNA	26191083
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DCAF7 mRNA	20938992
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of DCAF7 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of DCAF7 mRNA	25562108
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DCAF7 mRNA	21266533
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCAF7 mRNA	27188386
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DCAF7 protein	23301498
D017313	Fenretinide	Fenretinide results in increased expression of DCAF7 mRNA	28973697
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DCAF7 mRNA	20938992
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of DCAF7 mRNA	21179406
C492448	ICG 001	ICG 001 results in decreased expression of DCAF7 mRNA	26191083
D007213	Indomethacin	Indomethacin results in increased expression of DCAF7 mRNA	28201806
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DCAF7 mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of DCAF7 mRNA	23179753
D008825	Miconazole	Miconazole results in increased expression of DCAF7 mRNA	27462272
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of DCAF7 mRNA	25554681; 25620056;
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of DCAF7 mRNA	25554681; 25620056;
D009532	Nickel	Nickel results in decreased expression of DCAF7 mRNA	23195993
D009532	Nickel	Nickel results in increased expression of DCAF7 mRNA	25583101
D010100	Oxygen	[sulforafan affects the susceptibility to Oxygen] which affects the expression of DCAF7 mRNA	30529165
C016030	pantogab	pantogab results in decreased expression of DCAF7 mRNA	17379144
D010634	Phenobarbital	Phenobarbital affects the expression of DCAF7 mRNA	23091169
D011441	Propylthiouracil	Propylthiouracil results in increased expression of DCAF7 mRNA	24780913
C010327	salinomycin	salinomycin results in decreased expression of DCAF7 mRNA	19682730
C016766	sulforafan	[sulforafan affects the susceptibility to Oxygen] which affects the expression of DCAF7 mRNA	30529165
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of DCAF7 mRNA	15336504
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DCAF7 mRNA	21570461
C014215	tetrahydropalmatine	tetrahydropalmatine results in decreased expression of DCAF7 protein	20109541
D013849	Thimerosal	Thimerosal results in decreased expression of DCAF7 mRNA	27188386
D013853	Thioacetamide	Thioacetamide results in increased expression of DCAF7 mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of DCAF7 mRNA	19969065
C483909	torcetrapib	torcetrapib results in increased expression of DCAF7 mRNA	23228038
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DCAF7 mRNA	27188386
D000077288	Troglitazone	Troglitazone results in decreased expression of DCAF7 mRNA	28973697
D014635	Valproic Acid	Valproic Acid affects the expression of DCAF7 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of DCAF7 mRNA	23179753
D014635	Valproic Acid	Valproic Acid affects the expression of DCAF7 mRNA	17963808
D000077337	Vorinostat	Vorinostat results in decreased expression of DCAF7 mRNA	27188386

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-0963	Cytoplasm
KW-0217	Developmental protein
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0677	Repeat
KW-0833	Ubl conjugation pathway
KW-0853	WD repeat

Interpro

InterPro ID	InterPro Term
IPR015943	WD40/YVTN_repeat-like_dom_sf
IPR001680	WD40_repeat
IPR019775	WD40_repeat_CS
IPR017986	WD40_repeat_dom
IPR036322	WD40_repeat_dom_sf

PROSITE

PROSITE ID	PROSITE Term
PS00678	WD_REPEATS_1
PS50082	WD_REPEATS_2
PS50294	WD_REPEATS_REGION

Pfam

Pfam ID	Pfam Term
PF00400	WD40

Gene: DCAF7

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction