| Tag | Content |
|---|---|
| Uniprot ID | P63001; O95501; P15154; Q9BTB4; |
| Entrez ID | 19353 |
| Genbank protein ID | BAC28767.1; AAH03828.1; BAC40596.1; AAH51053.1; CAA40545.1; BAB69451.1; BAB26027.1; BAC33203.1; |
| Genbank nucleotide ID | NM_009007.2 |
| Ensembl protein ID | ENSMUSP00000079380 |
| Ensembl nucleotide ID | ENSMUSG00000001847 |
| Gene name | Ras-related C3 botulinum toxin substrate 1 |
| Gene symbol | Rac1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 20184871 |
| Functional description | Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states (PubMed:24352656). In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. In neurons, is involved in dendritic spine formation and synaptic plasticity (PubMed:24352656, PubMed:26969129). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. |
| Sequence | MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG 60 QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR 120 DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP 180 PVKKRKRKCL LL 192 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003924 | GTPase activity | ISO |
| GO:0003924 | GTPase activity | IDA |
| GO:0003924 | GTPase activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005525 | GTP binding | ISO |
| GO:0005525 | GTP binding | IDA |
| GO:0005525 | GTP binding | IBA |
| GO:0017137 | Rab GTPase binding | ISO |
| GO:0019899 | enzyme binding | ISO |
| GO:0019901 | protein kinase binding | ISO |
| GO:0019901 | protein kinase binding | IBA |
| GO:0030742 | GTP-dependent protein binding | IPI |
| GO:0031996 | thioesterase binding | ISO |
| GO:0042826 | histone deacetylase binding | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0051022 | Rho GDP-dissociation inhibitor binding | ISS |
| GO:0051022 | Rho GDP-dissociation inhibitor binding | ISO |
| GO:0051117 | ATPase binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001764 | neuron migration | IMP |
| GO:0001934 | positive regulation of protein phosphorylation | ISS |
| GO:0001934 | positive regulation of protein phosphorylation | ISO |
| GO:0002093 | auditory receptor cell morphogenesis | IMP |
| GO:0002551 | mast cell chemotaxis | ISO |
| GO:0003382 | epithelial cell morphogenesis | IMP |
| GO:0006897 | endocytosis | IDA |
| GO:0006911 | phagocytosis, engulfment | IMP |
| GO:0006935 | chemotaxis | ISO |
| GO:0006972 | hyperosmotic response | IDA |
| GO:0007010 | cytoskeleton organization | IDA |
| GO:0007015 | actin filament organization | ISO |
| GO:0007015 | actin filament organization | IBA |
| GO:0007155 | cell adhesion | IDA |
| GO:0007163 | establishment or maintenance of cell polarity | IBA |
| GO:0007186 | G protein-coupled receptor signaling pathway | IGI |
| GO:0007264 | small GTPase mediated signal transduction | IDA |
| GO:0007266 | Rho protein signal transduction | IBA |
| GO:0007411 | axon guidance | IMP |
| GO:0008045 | motor neuron axon guidance | IBA |
| GO:0008283 | cell population proliferation | ISO |
| GO:0008360 | regulation of cell shape | IBA |
| GO:0008361 | regulation of cell size | ISO |
| GO:0010591 | regulation of lamellipodium assembly | ISO |
| GO:0010592 | positive regulation of lamellipodium assembly | ISO |
| GO:0010762 | regulation of fibroblast migration | IMP |
| GO:0010811 | positive regulation of cell-substrate adhesion | ISO |
| GO:0014041 | regulation of neuron maturation | IGI |
| GO:0016358 | dendrite development | IDA |
| GO:0016477 | cell migration | IDA |
| GO:0016601 | Rac protein signal transduction | ISO |
| GO:0016601 | Rac protein signal transduction | IBA |
| GO:0021799 | cerebral cortex radially oriented cell migration | IMP |
| GO:0021831 | embryonic olfactory bulb interneuron precursor migration | IMP |
| GO:0021894 | cerebral cortex GABAergic interneuron development | IGI |
| GO:0022604 | regulation of cell morphogenesis | IGI |
| GO:0030031 | cell projection assembly | IBA |
| GO:0030032 | lamellipodium assembly | ISO |
| GO:0030032 | lamellipodium assembly | TAS |
| GO:0030032 | lamellipodium assembly | IDA |
| GO:0030036 | actin cytoskeleton organization | ISO |
| GO:0030036 | actin cytoskeleton organization | IBA |
| GO:0030041 | actin filament polymerization | IDA |
| GO:0030334 | regulation of cell migration | ISO |
| GO:0030334 | regulation of cell migration | IMP |
| GO:0030838 | positive regulation of actin filament polymerization | IDA |
| GO:0030865 | cortical cytoskeleton organization | IBA |
| GO:0030900 | forebrain development | IDA |
| GO:0031116 | positive regulation of microtubule polymerization | ISO |
| GO:0031529 | ruffle organization | ISO |
| GO:0032707 | negative regulation of interleukin-23 production | ISO |
| GO:0032956 | regulation of actin cytoskeleton organization | IBA |
| GO:0034446 | substrate adhesion-dependent cell spreading | ISO |
| GO:0034446 | substrate adhesion-dependent cell spreading | IDA |
| GO:0034446 | substrate adhesion-dependent cell spreading | IMP |
| GO:0035567 | non-canonical Wnt signaling pathway | IGI |
| GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus | ISO |
| GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus | IMP |
| GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | IMP |
| GO:0043652 | engulfment of apoptotic cell | IDA |
| GO:0043652 | engulfment of apoptotic cell | IBA |
| GO:0045216 | cell-cell junction organization | IMP |
| GO:0045428 | regulation of nitric oxide biosynthetic process | ISO |
| GO:0045453 | bone resorption | ISO |
| GO:0045740 | positive regulation of DNA replication | ISO |
| GO:0046425 | regulation of receptor signaling pathway via JAK-STAT | IMP |
| GO:0048012 | hepatocyte growth factor receptor signaling pathway | ISO |
| GO:0048168 | regulation of neuronal synaptic plasticity | IGI |
| GO:0048168 | regulation of neuronal synaptic plasticity | IMP |
| GO:0048532 | anatomical structure arrangement | IMP |
| GO:0048812 | neuron projection morphogenesis | IGI |
| GO:0048813 | dendrite morphogenesis | IGI |
| GO:0048870 | cell motility | ISS |
| GO:0048870 | cell motility | ISO |
| GO:0048873 | homeostasis of number of cells within a tissue | IGI |
| GO:0051492 | regulation of stress fiber assembly | ISO |
| GO:0051496 | positive regulation of stress fiber assembly | ISO |
| GO:0051668 | localization within membrane | ISO |
| GO:0051894 | positive regulation of focal adhesion assembly | ISO |
| GO:0051932 | synaptic transmission, GABAergic | IGI |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | IGI |
| GO:0060263 | regulation of respiratory burst | ISO |
| GO:0060999 | positive regulation of dendritic spine development | IGI |
| GO:0060999 | positive regulation of dendritic spine development | IMP |
| GO:0061344 | regulation of cell adhesion involved in heart morphogenesis | IMP |
| GO:0071260 | cellular response to mechanical stimulus | ISO |
| GO:0071526 | semaphorin-plexin signaling pathway | ISS |
| GO:0071526 | semaphorin-plexin signaling pathway | ISO |
| GO:0071542 | dopaminergic neuron differentiation | IGI |
| GO:0072659 | protein localization to plasma membrane | IDA |
| GO:0090023 | positive regulation of neutrophil chemotaxis | ISO |
| GO:0090023 | positive regulation of neutrophil chemotaxis | IMP |
| GO:0090103 | cochlea morphogenesis | IMP |
| GO:0097178 | ruffle assembly | ISO |
| GO:0097178 | ruffle assembly | IMP |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | ISO |
| GO:1902622 | regulation of neutrophil migration | IBA |
| GO:1904948 | midbrain dopaminergic neuron differentiation | IMP |
| GO:2000386 | positive regulation of ovarian follicle development | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000139 | Golgi membrane | ISO |
| GO:0000242 | pericentriolar material | IDA |
| GO:0001891 | phagocytic cup | IDA |
| GO:0005634 | nucleus | IDA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005737 | cytoplasm | IBA |
| GO:0005802 | trans-Golgi network | ISO |
| GO:0005829 | cytosol | ISS |
| GO:0005829 | cytosol | ISO |
| GO:0005856 | cytoskeleton | IBA |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IBA |
| GO:0005886 | plasma membrane | IDA |
| GO:0005886 | plasma membrane | TAS |
| GO:0005938 | cell cortex | IBA |
| GO:0016020 | membrane | ISO |
| GO:0016020 | membrane | IDA |
| GO:0019897 | extrinsic component of plasma membrane | IDA |
| GO:0030027 | lamellipodium | ISO |
| GO:0030027 | lamellipodium | IDA |
| GO:0031410 | cytoplasmic vesicle | ISO |
| GO:0031410 | cytoplasmic vesicle | IDA |
| GO:0031410 | cytoplasmic vesicle | IBA |
| GO:0031901 | early endosome membrane | IDA |
| GO:0032587 | ruffle membrane | ISO |
| GO:0032587 | ruffle membrane | IDA |
| GO:0036464 | cytoplasmic ribonucleoprotein granule | ISO |
| GO:0042470 | melanosome | IEA |
| GO:0042995 | cell projection | IDA |
| GO:0042995 | cell projection | IBA |
| GO:0043197 | dendritic spine | ISO |
| GO:0043197 | dendritic spine | IBA |
| GO:0043231 | intracellular membrane-bounded organelle | IBA |
| GO:0055038 | recycling endosome membrane | ISO |
| GO:0060091 | kinocilium | IDA |
| GO:0098794 | postsynapse | ISO |
| GO:0098978 | glutamatergic synapse | ISO |
| GO:0005884 | actin filament | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-114604 | GPVI-mediated activation cascade | IEA |
| R-MMU-1257604 | PIP3 activates AKT signaling | IEA |
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-1280218 | Adaptive Immune System | IEA |
| R-MMU-1433557 | Signaling by SCF-KIT | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-166520 | Signaling by NTRKs | IEA |
| R-MMU-168249 | Innate Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-193648 | NRAGE signals death through JNK | IEA |
| R-MMU-193704 | p75 NTR receptor-mediated signalling | IEA |
| R-MMU-194138 | Signaling by VEGF | IEA |
| R-MMU-194315 | Signaling by Rho GTPases | IEA |
| R-MMU-194840 | Rho GTPase cycle | IEA |
| R-MMU-195258 | RHO GTPase Effectors | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-199418 | Negative regulation of the PI3K/AKT network | IEA |
| R-MMU-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | IEA |
| R-MMU-2029482 | Regulation of actin dynamics for phagocytic cup formation | IEA |
| R-MMU-204998 | Cell death signalling via NRAGE, NRIF and NADE | IEA |
| R-MMU-2172127 | DAP12 interactions | IEA |
| R-MMU-2424491 | DAP12 signaling | IEA |
| R-MMU-2454202 | Fc epsilon receptor (FCERI) signaling | IEA |
| R-MMU-2682334 | EPH-Ephrin signaling | IEA |
| R-MMU-2871796 | FCERI mediated MAPK activation | IEA |
| R-MMU-373752 | Netrin-1 signaling | IEA |
| R-MMU-373755 | Semaphorin interactions | IEA |
| R-MMU-373760 | L1CAM interactions | IEA |
| R-MMU-376172 | DSCAM interactions | IEA |
| R-MMU-3858494 | Beta-catenin independent WNT signaling | IEA |
| R-MMU-388841 | Costimulation by the CD28 family | IEA |
| R-MMU-389356 | CD28 co-stimulation | IEA |
| R-MMU-389359 | CD28 dependent Vav1 pathway | IEA |
| R-MMU-3928662 | EPHB-mediated forward signaling | IEA |
| R-MMU-3928664 | Ephrin signaling | IEA |
| R-MMU-3928665 | EPH-ephrin mediated repulsion of cells | IEA |
| R-MMU-399954 | Sema3A PAK dependent Axon repulsion | IEA |
| R-MMU-400685 | Sema4D in semaphorin signaling | IEA |
| R-MMU-4086400 | PCP/CE pathway | IEA |
| R-MMU-416550 | Sema4D mediated inhibition of cell attachment and migration | IEA |
| R-MMU-418885 | DCC mediated attractive signaling | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| R-MMU-4420097 | VEGFA-VEGFR2 Pathway | IEA |
| R-MMU-445144 | Signal transduction by L1 | IEA |
| R-MMU-5218920 | VEGFR2 mediated vascular permeability | IEA |
| R-MMU-5625740 | RHO GTPases activate PKNs | IEA |
| R-MMU-5625900 | RHO GTPases activate CIT | IEA |
| R-MMU-5625970 | RHO GTPases activate KTN1 | IEA |
| R-MMU-5626467 | RHO GTPases activate IQGAPs | IEA |
| R-MMU-5627123 | RHO GTPases activate PAKs | IEA |
| R-MMU-5663213 | RHO GTPases Activate WASPs and WAVEs | IEA |
| R-MMU-5663220 | RHO GTPases Activate Formins | IEA |
| R-MMU-5668599 | RHO GTPases Activate NADPH Oxidases | IEA |
| R-MMU-5683057 | MAPK family signaling cascades | IEA |
| R-MMU-5687128 | MAPK6/MAPK4 signaling | IEA |
| R-MMU-6798695 | Neutrophil degranulation | IEA |
| R-MMU-6806834 | Signaling by MET | IEA |
| R-MMU-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | IEA |
| R-MMU-73887 | Death Receptor Signalling | IEA |
| R-MMU-76002 | Platelet activation, signaling and aggregation | IEA |
| R-MMU-8848021 | Signaling by PTK6 | IEA |
| R-MMU-8849471 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | IEA |
| R-MMU-8875555 | MET activates RAP1 and RAC1 | IEA |
| R-MMU-8875878 | MET promotes cell motility | IEA |
| R-MMU-9006115 | Signaling by NTRK2 (TRKB) | IEA |
| R-MMU-9006925 | Intracellular signaling by second messengers | IEA |
| R-MMU-9006927 | Signaling by Non-Receptor Tyrosine Kinases | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| R-MMU-9032500 | Activated NTRK2 signals through FYN | IEA |
| R-MMU-9032759 | NTRK2 activates RAC1 | IEA |
| R-MMU-983231 | Factors involved in megakaryocyte development and platelet production | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51420 | RHO |
| Pfam ID | Pfam Term |
|---|---|
| PF00071 | Ras |