| Tag | Content |
|---|---|
| Uniprot ID | P70662; O55204; Q1EQX2; Q71V68; |
| Entrez ID | 16825 |
| Genbank protein ID | AAC40064.1; AAC52887.1; AAC52933.1; AAB94131.1; BAE95401.1; AAH13624.1; AAB96885.1; |
| Genbank nucleotide ID | NM_001113408.1; XM_011247157.1; NM_010697.1; |
| Ensembl protein ID | ENSMUSP00000114667; ENSMUSP00000026252; ENSMUSP00000118546; ENSMUSP00000139562; ENSMUSP00000053680; |
| Ensembl nucleotide ID | ENSMUSG00000025223 |
| Gene name | LIM domain-binding protein 1 |
| Gene symbol | Ldb1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 24433583 |
| Functional description | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. |
| Sequence | MSVGCACPGC SSKSFKLYSP KEPPNGNAFP PFHPGTMLDR DVGPTPMYPP TYLEPGIGRH 60 TPYGNQTDYR IFELNKRLQN WTEECDNLWW DAFTTEFFED DAMLTITFCL EDGPKRYTIG 120 RTLIPRYFRS IFEGGATELY YVLKHPKEAF HSNFVSLDCD QGSMVTQHGK PMFTQVCVEG 180 RLYLEFMFDD MMRIKTWHFS IRQHRELIPR SILAMHAQDP QMLDQLSKNI TRCGLSNSTL 240 NYLRLCVILE PMQELMSRHK TYSLSPRDCL KTCLFQKWQR MVAPPAEPAR QQPSKRRKRK 300 MSGGSTMSSG GGNTNNSNSK KKSPASTFAL SSQVPDVMVV GEPTLMGGEF GDEDERLITR 360 LENTQFDAAN GIDDEDSFNN SPALGANSPW NSKPPSSQES KSENPTSQAS Q 411 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000987 | cis-regulatory region sequence-specific DNA binding | IDA |
| GO:0001102 | RNA polymerase II activating transcription factor binding | ISO |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IBA |
| GO:0003682 | chromatin binding | IDA |
| GO:0003712 | transcription coregulator activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005515 | protein binding | TAS |
| GO:0019899 | enzyme binding | ISO |
| GO:0019899 | enzyme binding | IPI |
| GO:0030274 | LIM domain binding | ISO |
| GO:0030274 | LIM domain binding | IBA |
| GO:0030274 | LIM domain binding | IDA |
| GO:0030274 | LIM domain binding | IPI |
| GO:0042803 | protein homodimerization activity | IDA |
| GO:0043621 | protein self-association | IPI |
| GO:0003677 | DNA binding | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA |
| GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery | IMP |
| GO:0001702 | gastrulation with mouth forming second | IMP |
| GO:0001942 | hair follicle development | IGI |
| GO:0006366 | transcription by RNA polymerase II | IDA |
| GO:0007275 | multicellular organism development | IBA |
| GO:0009948 | anterior/posterior axis specification | IMP |
| GO:0010669 | epithelial structure maintenance | IGI |
| GO:0016055 | Wnt signaling pathway | IMP |
| GO:0021549 | cerebellum development | IMP |
| GO:0021702 | cerebellar Purkinje cell differentiation | IMP |
| GO:0022607 | cellular component assembly | IGI |
| GO:0030154 | cell differentiation | TAS |
| GO:0030182 | neuron differentiation | IEP |
| GO:0030334 | regulation of cell migration | IDA |
| GO:0032784 | regulation of DNA-templated transcription, elongation | IMP |
| GO:0035019 | somatic stem cell population maintenance | IGI |
| GO:0043549 | regulation of kinase activity | IDA |
| GO:0043973 | histone H3-K4 acetylation | IMP |
| GO:0045647 | negative regulation of erythrocyte differentiation | IMP |
| GO:0045785 | positive regulation of cell adhesion | IGI |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISO |
| GO:0045892 | negative regulation of transcription, DNA-templated | IBA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IGI |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IMP |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO:0046985 | positive regulation of hemoglobin biosynthetic process | IMP |
| GO:0048382 | mesendoderm development | IMP |
| GO:0051893 | regulation of focal adhesion assembly | IDA |
| GO:0060319 | primitive erythrocyte differentiation | TAS |
| GO:0060322 | head development | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000790 | nuclear chromatin | ISO |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005667 | transcription factor complex | ISO |
| GO:0005667 | transcription factor complex | IBA |
| GO:0005667 | transcription factor complex | IDA |
| GO:0031252 | cell leading edge | IDA |
| GO:0032991 | protein-containing complex | IDA |
| GO:0032991 | protein-containing complex | IPI |
| GO:1990907 | beta-catenin-TCF complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| R-MMU-8878171 | Transcriptional regulation by RUNX1 | IEA |
| R-MMU-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | IEA |