| Tag | Content |
|---|---|
| Uniprot ID | P70662; O55204; Q1EQX2; Q71V68; |
| Entrez ID | 16825 |
| Genbank protein ID | AAC40064.1; AAC52887.1; AAC52933.1; AAB94131.1; BAE95401.1; AAH13624.1; AAB96885.1; |
| Genbank nucleotide ID | NM_001113408.1; XM_011247157.1; NM_010697.1; |
| Ensembl protein ID | ENSMUSP00000114667; ENSMUSP00000026252; ENSMUSP00000118546; ENSMUSP00000139562; ENSMUSP00000053680; |
| Ensembl nucleotide ID | ENSMUSG00000025223 |
| Gene name | LIM domain-binding protein 1 |
| Gene symbol | Ldb1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 24433583 |
| Functional description | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. |
| Sequence | MSVGCACPGC SSKSFKLYSP KEPPNGNAFP PFHPGTMLDR DVGPTPMYPP TYLEPGIGRH 60 TPYGNQTDYR IFELNKRLQN WTEECDNLWW DAFTTEFFED DAMLTITFCL EDGPKRYTIG 120 RTLIPRYFRS IFEGGATELY YVLKHPKEAF HSNFVSLDCD QGSMVTQHGK PMFTQVCVEG 180 RLYLEFMFDD MMRIKTWHFS IRQHRELIPR SILAMHAQDP QMLDQLSKNI TRCGLSNSTL 240 NYLRLCVILE PMQELMSRHK TYSLSPRDCL KTCLFQKWQR MVAPPAEPAR QQPSKRRKRK 300 MSGGSTMSSG GGNTNNSNSK KKSPASTFAL SSQVPDVMVV GEPTLMGGEF GDEDERLITR 360 LENTQFDAAN GIDDEDSFNN SPALGANSPW NSKPPSSQES KSENPTSQAS Q 411 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
