| Tag | Content |
|---|---|
| Uniprot ID | P80206 |
| Entrez ID | |
| Genbank protein ID | CAA48755.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Homeobox protein OTX2 |
| Gene symbol | Otx2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 7590242 |
| Functional description | Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'. |
| Sequence | MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL DVLEALFAKT 60 RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ QNGGQNKVRP AKKKSSPARE 120 VSSESGTSGQ FTPPSSTSVP TIASSSAPVS IWSPASISPL SDPLSTSSSC MQRSYPMTYT 180 QASGYSQGYA GSTSYFGGMD CGSYLTPMHH QLPGPGATLS PMGTNAVTSH LNQSPASLST 240 QGYGASSLGF NSTTDCLDYK DQTASWKLNF NADCLDYKDQ TSSWKFQVL 289 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | ISO |
| GO:0000987 | cis-regulatory region sequence-specific DNA binding | TAS |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | ISO |
| GO:0003700 | DNA-binding transcription factor activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001708 | cell fate specification | IMP |
| GO:0006357 | regulation of transcription by RNA polymerase II | IDA |
| GO:0007411 | axon guidance | ISO |
| GO:0007417 | central nervous system development | IMP |
| GO:0007492 | endoderm development | IGI |
| GO:0009887 | animal organ morphogenesis | IMP |
| GO:0009952 | anterior/posterior pattern specification | IGI |
| GO:0009952 | anterior/posterior pattern specification | IMP |
| GO:0009953 | dorsal/ventral pattern formation | IMP |
| GO:0021978 | telencephalon regionalization | IMP |
| GO:0022037 | metencephalon development | IGI |
| GO:0030154 | cell differentiation | IMP |
| GO:0030154 | cell differentiation | TAS |
| GO:0030182 | neuron differentiation | IMP |
| GO:0030900 | forebrain development | IMP |
| GO:0030900 | forebrain development | IGI |
| GO:0030901 | midbrain development | IMP |
| GO:0030901 | midbrain development | IGI |
| GO:0032525 | somite rostral/caudal axis specification | IMP |
| GO:0040019 | positive regulation of embryonic development | IMP |
| GO:0042472 | inner ear morphogenesis | IGI |
| GO:0042706 | eye photoreceptor cell fate commitment | IMP |
| GO:0045165 | cell fate commitment | IMP |
| GO:0045893 | positive regulation of transcription, DNA-templated | IMP |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IGI |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA |
| GO:0048382 | mesendoderm development | IMP |
| GO:0048663 | neuron fate commitment | IMP |
| GO:0048664 | neuron fate determination | IMP |
| GO:0048709 | oligodendrocyte differentiation | IMP |
| GO:0048852 | diencephalon morphogenesis | IGI |
| GO:0048856 | anatomical structure development | IGI |
| GO:0065003 | protein-containing complex assembly | ISO |
| GO:0071542 | dopaminergic neuron differentiation | ISO |
| GO:0090009 | primitive streak formation | IMP |
| GO:1990830 | cellular response to leukemia inhibitory factor | IEP |
| GO:2000543 | positive regulation of gastrulation | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IC |
| GO:0005667 | transcription factor complex | IDA |
| GO:0005737 | cytoplasm | IDA |
| GO:0030426 | growth cone | ISO |
| GO:0032991 | protein-containing complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|