| Tag | Content |
|---|---|
| Uniprot ID | Q00731; O70123; Q66S31; Q6GT23; Q6WZL9; |
| Entrez ID | 22339 |
| Genbank protein ID | AAB22253.1; AAU95484.1; AAC05442.1; AAH61468.1; AAU11325.1; AAB22252.1; AAU95485.1; AAB22254.1; AAP86647.1; AAA40547.1; |
| Genbank nucleotide ID | NM_001287058.1; NM_001287057.1; NM_009505.4; NM_001025257.3; NM_001110267.1; NM_001287056.1; NM_001110266.1; NM_001110268.1; NM_001317041.1; NM_001025250.3; |
| Ensembl protein ID | ENSMUSP00000149539; ENSMUSP00000024747; |
| Ensembl nucleotide ID | ENSMUSG00000023951 |
| Gene name | Vascular endothelial growth factor A |
| Gene symbol | Vegfa |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 12539040 |
| Functional description | Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). |
| Sequence | MNFLLSWVHW TLALLLYLHH AKWSQAAPTT EGEQKSHEVI KFMDVYQRSY CRPIETLVDI 60 FQEYPDEIEY IFKPSCVPLM RCAGCCNDEA LECVPTSESN ITMQIMRIKP HQSQHIGEMS 120 FLQHSRCECR PKKDRTKPEK KSVRGKGKGQ KRKRKKSRFK SWSVHCEPCS ERRKHLFVQD 180 PQTCKCSCKN TDSRCKARQL ELNERTCRCD KPRR 214 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.