CleftGeneDB-Search

Gene: Vegfa

Basic information

Tag	Content
Uniprot ID	Q00731; O70123; Q66S31; Q6GT23; Q6WZL9;
Entrez ID	22339
Genbank protein ID	AAB22253.1; AAU95484.1; AAC05442.1; AAH61468.1; AAU11325.1; AAB22252.1; AAU95485.1; AAB22254.1; AAP86647.1; AAA40547.1;
Genbank nucleotide ID	NM_001287058.1; NM_001287057.1; NM_009505.4; NM_001025257.3; NM_001110267.1; NM_001287056.1; NM_001110266.1; NM_001110268.1; NM_001317041.1; NM_001025250.3;
Ensembl protein ID	ENSMUSP00000149539; ENSMUSP00000024747;
Ensembl nucleotide ID	ENSMUSG00000023951
Gene name	Vascular endothelial growth factor A
Gene symbol	Vegfa
Organism	Mus musculus
NCBI taxa ID	10090
Cleft type	CPO
Developmental stage
Data sources	Manually collected
Reference	12539040
Functional description	Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042).
Sequence	MNFLLSWVHW TLALLLYLHH AKWSQAAPTT EGEQKSHEVI KFMDVYQRSY CRPIETLVDI 60 FQEYPDEIEY IFKPSCVPLM RCAGCCNDEA LECVPTSESN ITMQIMRIKP HQSQHIGEMS 120 FLQHSRCECR PKKDRTKPEK KSVRGKGKGQ KRKRKKSRFK SWSVHCEPCS ERRKHLFVQD 180 PQTCKCSCKN TDSRCKARQL ELNERTCRCD KPRR 214

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0001968	fibronectin binding	ISS
GO:0001968	fibronectin binding	ISO
GO:0005125	cytokine activity	ISS
GO:0005125	cytokine activity	ISO
GO:0005161	platelet-derived growth factor receptor binding	ISS
GO:0005161	platelet-derived growth factor receptor binding	ISO
GO:0005172	vascular endothelial growth factor receptor binding	ISS
GO:0005172	vascular endothelial growth factor receptor binding	ISO
GO:0005172	vascular endothelial growth factor receptor binding	IBA
GO:0005515	protein binding	IPI
GO:0008083	growth factor activity	ISS
GO:0008083	growth factor activity	ISO
GO:0008083	growth factor activity	IBA
GO:0008201	heparin binding	ISS
GO:0008201	heparin binding	ISO
GO:0019838	growth factor binding	ISO
GO:0038191	neuropilin binding	ISO
GO:0042056	chemoattractant activity	ISS
GO:0042056	chemoattractant activity	ISO
GO:0042056	chemoattractant activity	IBA
GO:0042802	identical protein binding	ISO
GO:0043183	vascular endothelial growth factor receptor 1 binding	ISS
GO:0043183	vascular endothelial growth factor receptor 1 binding	ISO
GO:0043183	vascular endothelial growth factor receptor 1 binding	IBA
GO:0043184	vascular endothelial growth factor receptor 2 binding	ISS
GO:0043184	vascular endothelial growth factor receptor 2 binding	ISO
GO:0043184	vascular endothelial growth factor receptor 2 binding	IBA
GO:0048018	receptor ligand activity	ISS
GO:0048018	receptor ligand activity	ISO

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000122	negative regulation of transcription by RNA polymerase II	ISO
GO:0001525	angiogenesis	ISO
GO:0001525	angiogenesis	IDA
GO:0001525	angiogenesis	IMP
GO:0001525	angiogenesis	IGI
GO:0001525	angiogenesis	IBA
GO:0001541	ovarian follicle development	IMP
GO:0001568	blood vessel development	IMP
GO:0001666	response to hypoxia	ISS
GO:0001666	response to hypoxia	ISO
GO:0001666	response to hypoxia	IBA
GO:0001701	in utero embryonic development	IMP
GO:0001822	kidney development	IMP
GO:0001934	positive regulation of protein phosphorylation	ISS
GO:0001934	positive regulation of protein phosphorylation	ISO
GO:0001934	positive regulation of protein phosphorylation	IBA
GO:0001938	positive regulation of endothelial cell proliferation	ISO
GO:0001938	positive regulation of endothelial cell proliferation	IBA
GO:0001944	vasculature development	IMP
GO:0001946	lymphangiogenesis	IGI
GO:0001974	blood vessel remodeling	ISO
GO:0002040	sprouting angiogenesis	IBA
GO:0002042	cell migration involved in sprouting angiogenesis	ISS
GO:0002042	cell migration involved in sprouting angiogenesis	ISO
GO:0002052	positive regulation of neuroblast proliferation	IGI
GO:0002092	positive regulation of receptor internalization	ISS
GO:0002092	positive regulation of receptor internalization	ISO
GO:0002575	basophil chemotaxis	ISO
GO:0003007	heart morphogenesis	IMP
GO:0006357	regulation of transcription by RNA polymerase II	ISO
GO:0007399	nervous system development	ISO
GO:0007498	mesoderm development	IMP
GO:0007595	lactation	IMP
GO:0008283	cell population proliferation	IMP
GO:0008284	positive regulation of cell population proliferation	ISO
GO:0008284	positive regulation of cell population proliferation	IDA
GO:0008360	regulation of cell shape	ISS
GO:0008360	regulation of cell shape	ISO
GO:0009967	positive regulation of signal transduction	ISO
GO:0010595	positive regulation of endothelial cell migration	ISS
GO:0010595	positive regulation of endothelial cell migration	ISO
GO:0010628	positive regulation of gene expression	ISO
GO:0010629	negative regulation of gene expression	ISO
GO:0010629	negative regulation of gene expression	IMP
GO:0010719	negative regulation of epithelial to mesenchymal transition	IMP
GO:0010749	regulation of nitric oxide mediated signal transduction	ISO
GO:0016477	cell migration	IDA
GO:0016477	cell migration	IGI
GO:0022408	negative regulation of cell-cell adhesion	IGI
GO:0030224	monocyte differentiation	ISS
GO:0030224	monocyte differentiation	ISO
GO:0030225	macrophage differentiation	ISS
GO:0030225	macrophage differentiation	ISO
GO:0030324	lung development	IMP
GO:0030335	positive regulation of cell migration	ISO
GO:0030855	epithelial cell differentiation	IMP
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	ISS
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO
GO:0031077	post-embryonic camera-type eye development	IMP
GO:0031334	positive regulation of protein-containing complex assembly	ISS
GO:0031334	positive regulation of protein-containing complex assembly	ISO
GO:0031954	positive regulation of protein autophosphorylation	ISS
GO:0031954	positive regulation of protein autophosphorylation	ISO
GO:0032147	activation of protein kinase activity	ISS
GO:0032147	activation of protein kinase activity	ISO
GO:0032793	positive regulation of CREB transcription factor activity	ISS
GO:0032793	positive regulation of CREB transcription factor activity	ISO
GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISS
GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO
GO:0035148	tube formation	ISS
GO:0035148	tube formation	ISO
GO:0035767	endothelial cell chemotaxis	ISS
GO:0035767	endothelial cell chemotaxis	ISO
GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISS
GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO
GO:0035924	cellular response to vascular endothelial growth factor stimulus	IGI
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	ISS
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	ISO
GO:0038084	vascular endothelial growth factor signaling pathway	ISO
GO:0038084	vascular endothelial growth factor signaling pathway	IBA
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	ISS
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	ISO
GO:0038190	VEGF-activated neuropilin signaling pathway	ISO
GO:0040008	regulation of growth	IMP
GO:0042088	T-helper 1 type immune response	ISO
GO:0042327	positive regulation of phosphorylation	ISO
GO:0042462	eye photoreceptor cell development	IMP
GO:0043066	negative regulation of apoptotic process	ISS
GO:0043066	negative regulation of apoptotic process	ISO
GO:0043066	negative regulation of apoptotic process	IMP
GO:0043069	negative regulation of programmed cell death	ISO
GO:0043117	positive regulation of vascular permeability	ISO
GO:0043117	positive regulation of vascular permeability	IDA
GO:0043129	surfactant homeostasis	IMP
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO
GO:0043406	positive regulation of MAP kinase activity	ISS
GO:0043406	positive regulation of MAP kinase activity	ISO
GO:0043536	positive regulation of blood vessel endothelial cell migration	ISS
GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO
GO:0043542	endothelial cell migration	IMP
GO:0045599	negative regulation of fat cell differentiation	IMP
GO:0045601	regulation of endothelial cell differentiation	IDA
GO:0045669	positive regulation of osteoblast differentiation	IMP
GO:0045766	positive regulation of angiogenesis	ISS
GO:0045766	positive regulation of angiogenesis	ISO
GO:0045766	positive regulation of angiogenesis	IDA
GO:0045766	positive regulation of angiogenesis	IBA
GO:0045779	negative regulation of bone resorption	ISO
GO:0045785	positive regulation of cell adhesion	ISS
GO:0045785	positive regulation of cell adhesion	ISO
GO:0045944	positive regulation of transcription by RNA polymerase II	ISS
GO:0045944	positive regulation of transcription by RNA polymerase II	ISO
GO:0048010	vascular endothelial growth factor receptor signaling pathway	ISO
GO:0048010	vascular endothelial growth factor receptor signaling pathway	IBA
GO:0048255	mRNA stabilization	ISO
GO:0048286	lung alveolus development	ISO
GO:0048469	cell maturation	IMP
GO:0048514	blood vessel morphogenesis	IDA
GO:0048514	blood vessel morphogenesis	IGI
GO:0048514	blood vessel morphogenesis	IMP
GO:0048593	camera-type eye morphogenesis	IMP
GO:0048661	positive regulation of smooth muscle cell proliferation	ISO
GO:0048739	cardiac muscle fiber development	IMP
GO:0048842	positive regulation of axon extension involved in axon guidance	IMP
GO:0048844	artery morphogenesis	IMP
GO:0048873	homeostasis of number of cells within a tissue	IMP
GO:0050679	positive regulation of epithelial cell proliferation	IMP
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISS
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA
GO:0050918	positive chemotaxis	ISO
GO:0050918	positive chemotaxis	IDA
GO:0050927	positive regulation of positive chemotaxis	ISS
GO:0050927	positive regulation of positive chemotaxis	ISO
GO:0050930	induction of positive chemotaxis	ISO
GO:0050930	induction of positive chemotaxis	IBA
GO:0051272	positive regulation of cellular component movement	ISS
GO:0051272	positive regulation of cellular component movement	ISO
GO:0051781	positive regulation of cell division	IEA
GO:0051894	positive regulation of focal adhesion assembly	ISS
GO:0051894	positive regulation of focal adhesion assembly	ISO
GO:0060319	primitive erythrocyte differentiation	IMP
GO:0060326	cell chemotaxis	ISO
GO:0060346	bone trabecula formation	IMP
GO:0060426	lung vasculature development	IMP
GO:0060749	mammary gland alveolus development	IMP
GO:0060754	positive regulation of mast cell chemotaxis	ISO
GO:0060754	positive regulation of mast cell chemotaxis	IBA
GO:0060978	angiogenesis involved in coronary vascular morphogenesis	ISO
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	ISO
GO:0061430	bone trabecula morphogenesis	IMP
GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO
GO:0071456	cellular response to hypoxia	ISS
GO:0071456	cellular response to hypoxia	ISO
GO:0071542	dopaminergic neuron differentiation	IGI
GO:0071679	commissural neuron axon guidance	IMP
GO:0090037	positive regulation of protein kinase C signaling	ISS
GO:0090037	positive regulation of protein kinase C signaling	ISO
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	ISS
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	ISO
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IDA
GO:0090259	regulation of retinal ganglion cell axon guidance	IMP
GO:0097475	motor neuron migration	IMP
GO:0097533	cellular stress response to acid chemical	ISO
GO:0120162	positive regulation of cold-induced thermogenesis	IMP
GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	ISS
GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	ISO
GO:1900745	positive regulation of p38MAPK cascade	ISO
GO:1901215	negative regulation of neuron death	ISO
GO:1901492	positive regulation of lymphangiogenesis	IDA
GO:1901532	regulation of hematopoietic progenitor cell differentiation	IDA
GO:1901727	positive regulation of histone deacetylase activity	ISO
GO:1902966	positive regulation of protein localization to early endosome	ISO
GO:1903141	negative regulation of establishment of endothelial barrier	ISO
GO:1903392	negative regulation of adherens junction organization	ISO
GO:1903572	positive regulation of protein kinase D signaling	ISS
GO:1903572	positive regulation of protein kinase D signaling	ISO
GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO
GO:1903672	positive regulation of sprouting angiogenesis	ISO
GO:1905604	negative regulation of maintenance of permeability of blood-brain barrier	ISO
GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	ISO
GO:2000573	positive regulation of DNA biosynthetic process	ISO

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005604	basement membrane	ISO
GO:0005615	extracellular space	ISO
GO:0005615	extracellular space	IDA
GO:0005615	extracellular space	IBA
GO:0005615	extracellular space	HDA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	ISO
GO:0005737	cytoplasm	IDA
GO:0005886	plasma membrane	IEA
GO:0005912	adherens junction	ISO
GO:0009986	cell surface	ISS
GO:0009986	cell surface	ISO
GO:0030141	secretory granule	ISS
GO:0030141	secretory granule	ISO
GO:0031982	vesicle	ISO

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-MMU-109582	Hemostasis	IEA
R-MMU-114608	Platelet degranulation	IEA
R-MMU-162582	Signal Transduction	IEA
R-MMU-194138	Signaling by VEGF	IEA
R-MMU-194313	VEGF ligand-receptor interactions	IEA
R-MMU-195399	VEGF binds to VEGFR leading to receptor dimerization	IEA
R-MMU-4420097	VEGFA-VEGFR2 Pathway	IEA
R-MMU-5218921	VEGFR2 mediated cell proliferation	IEA
R-MMU-76002	Platelet activation, signaling and aggregation	IEA
R-MMU-76005	Response to elevated platelet cytosolic Ca2+	IEA
R-MMU-9006934	Signaling by Receptor Tyrosine Kinases	IEA

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0024	Alternative initiation
KW-0877	Alternative promoter usage
KW-0025	Alternative splicing
KW-0037	Angiogenesis
KW-1003	Cell membrane
KW-0217	Developmental protein
KW-0221	Differentiation
KW-1015	Disulfide bond
KW-0325	Glycoprotein
KW-0339	Growth factor
KW-0358	Heparin-binding
KW-0472	Membrane
KW-0497	Mitogen
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal

Interpro

InterPro ID	InterPro Term
IPR029034	Cystine-knot_cytokine
IPR023581	PD_growth_factor_CS
IPR000072	PDGF/VEGF_dom
IPR027928	VEGF_C
IPR036841	VEGF_C_sf

PROSITE

PROSITE ID	PROSITE Term
PS00249	PDGF_1
PS50278	PDGF_2

Pfam

Pfam ID	Pfam Term
PF00341	PDGF
PF14554	VEGF_C

Gene: Vegfa

Basic information

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction