| Tag | Content |
|---|---|
| Uniprot ID | Q05793 |
| Entrez ID | 15530 |
| Genbank protein ID | AAA39911.1; AAA39899.1; AAA39912.1; |
| Genbank nucleotide ID | NM_008305.3 |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Basement membrane-specific heparan sulfate proteoglycan core protein |
| Gene symbol | Hspg2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 10579729 |
| Functional description | Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (By similarity). |
| Sequence | MGQRAVGSLL LGLLLHARLL AVTHGLRAYD GLSLPEDTET VTASRYGWTY SYLSDDEDLL 60 ADDASGDGLG SGDVGSGDFQ MVYFRALVNF TRSIEYSPQL EDASAKEFRE VSEAVVEKLE 120 PEYRKIPGDQ IVSVVFIKEL DGWVFVELDV GSEGNADGSQ IQEVLHTVVS SGSIGPYVTS 180 PWGFKFRRLG TVPQFPRVCT ETEFACHSYN ECVALEYRCD RRPDCRDMSD ELNCEEPVPE 240 LSSSTPAVGK VSPLPLWPEA ATTPPPPVTH GPQFLLPSVP GPSACGPQEA SCHSGHCIPR 300 DYLCDGQEDC RDGSDELGCA SPPPCEPNEF ACENGHCALK LWRCDGDFDC EDRTDEANCS 360 VKQPGEVCGP THFQCVSTNR CIPASFHCDE ESDCPDRSDE FGCMPPQVVT PPQQSIQASR 420 GQTVTFTCVA TGVPTPIINW RLNWGHIPAH PRVTMTSEGG RGTLIIRDVK EADQGAYTCE 480 AMNSRGMVFG IPDGVLELVP QRGPCPDGHF YLEDSASCLP CFCFGVTNVC QSSLRFRDQI 540 RLSFDQPNDF KGVNVTMPSQ PGVPPLSSTQ LQIDPALQEF QLVDLSRRFL VHDAFWALPK 600 QFLGNKVDSY GGFLRYKVRY ELARGMLEPV QKPDVILVGA GYRLHSRGHT PTHPGTLNQR 660 QVQLSEEHWV HESGRPVQRA EMLQALASLE AVLLQTVYNT KMASVGLSDI VMDTTVTHTT 720 IHGRAHSVEE CRCPIGYSGL SCESCDAHFT RVPGGPYLGT CSGCNCNGHA SSCDPVYGHC 780 LNCQHNTEGP QCDKCKPGFF GDATKATATA CRPCPCPYID ASRRFSDTCF LDTDGQATCD 840 ACAPGYTGRR CESCAPGYEG NPIQPGGKCR PTTQEIVRCD ERGSLGTSGE TCRCKNNVVG 900 RLCNECSDGS FHLSKQNPDG CLKCFCMGVS RQCSSSSWSR AQVLGASEQP SQFSLSNAAG 960 THTTSEGVSS PAPGELSFSS FHNLLSEPYF WSLPASFRGD KVTSYGGELR FTVMQRPRPS 1020 SAPLHRQPLV VLQGNNIVLE HHASRDPSPG QPSNFIVPFQ EQAWQRPDGQ PATREHLLMA 1080 LAGIDALLIQ ASYTQQPAES RLSGISMDVA VPENTGQDSA REVEQCTCPP GYRGPSCQDC 1140 DTGYTRVPSG LYLGTCERCN CHGHSETCEP ETGACQSCQH HTEGASCEQC QPGYYGDAQR 1200 GTPQDCQPCP CYGAPAAGQA AHTCFLDTDG HPTCDSCSPG HSGRHCERCA PGYYGNPSQG 1260 QPCHRDGQVP EVLGCGCDPH GSISSQCDAA GQCQCKAQVE GRSCSHCRPH HFHLSASNPE 1320 GCLPCFCMGV TQQCASSSYS RQLISTHFAP GDFQGFALVN PQRNSQLTGG FTVEPVHDGA 1380 RLSFSNFAHL GQESFYWQLP EIYQGDKVAA YGGKLRYTLS YTAGPQGSPL LDPDIQITGN 1440 NIMLVASQPA LQGPERRSYE IIFREEFWRR PDGQPATREH LLMALADLDE LLVRATFSSV 1500 PRAASISAVS LEGAQPGPSS GPRALEVEEC RCPPGYVGLS CQDCAPGYTR TGSGLYLGQC 1560 ELCECNGHSD LCHPETGACS RCQHNTAGEF CELCATGYYG DATAGTPEDC QPCACPLTNP 1620 ENMFSRTCES LGAGGYRCTA CEPGYTGQYC EQCAPGYEGD PNVQGGRCQP LTKESLEVQI 1680 HPSRSVVPQG GPHSLRCQVS GSPPHYFYWS REDGRPLPSS AQQRHQGSEL HFPSVQPSDA 1740 GVYICTCRNL IHTSNSRAEL LVAEAPSKPI MVTVEEQRSQ SVRPGADVTF ICTAKSKSPA 1800 YTLVWTRLHN GKLPSRAMDF NGILTIRNVQ PSDAGTYVCT GSNMFAMDQG TATLHVQVSG 1860 TSTAPVASIH PPQLTVQPGQ QAEFRCSATG NPTPMLEWIG GPSGQLPAKA QIHNGILRLP 1920 AIEPSDQGQY LCRALSSAGQ HVARAMLQVH GGSGPRVQVS PERTQVHEGR TVRLYCRAAG 1980 VPSASITWRK EGGSLPFRHQ AHGSRLRLHH MSVADSGEYV CRANNNIDAQ ETSIMISVSP 2040 STNSPPAPAS PAPIRIESSS SRVAEGQTLD LNCVVPGHAH AQVTWHKRGG SLPTHHQTHG 2100 SRLRLYQVSS ADSGEYVCSV LSSSGPLEAS VLVSITPAAA NVHIPGVVPP IRIETSSSRV 2160 AEGQTLDLSC VVPGQAHAQV TWHKRGGSLP AGHQVHGHML RLNRVSPADS GEYSCQVTGS 2220 SGTLEASVLV TIEASEPSPI PAPGLAQPVY IESSSSHLTE GQTVDLKCVV PGQAHAQVTW 2280 HKRGSSLPAR HQTHGSLLRL YQLSPADSGE YVCQVAGSSH PEHEASFKLT VPSSQNSSFR 2340 LRSPVISIEP PSSTVQQGQD ASFKCLIHEG AMPIKVEWKI RDQELEDNVH ISPNGSIITI 2400 VAPGPATMEP TACVASNVYG MAQSVVNLSV HGPPTVSVLP EGPVHVKMGK DITLECISSG 2460 EPRSSPRWTR LGIPVKLEPR MFGLMNSHAM LKIASVKPSD AGTYVCQAQN ALGTAQKQVE 2520 LIVDTGTVAP GTPQVQVEES ELTLEAGHTA TLHCSATGNP PPTIHWSKLR APLPWQHRIE 2580 GNTLVIPRVA QQDSGQYICN ATNSAGHTEA TVVLHVESPP YATIIPEHTS AQPGNLVQLQ 2640 CLAHGTPPLT YQWSLVGGVL PEKAVVRNQL LRLEPTVPED SGRYRCQVSN RVGSAEAFAQ 2700 VLVQGSSSNL PDTSIPGGST PTVQVTPQLE TRNIGASVEF HCAVPNERGT HLRWLKEGGQ 2760 LPPGHSVQDG VLRIQNLDQN CQGTYVCQAH GPWGQAQATA QLIVQALPSV LINVRTSVHS 2820 VVVGHSVEFE CLALGDPKPQ VTWSKVGGHL RPGIVQSGTI IRIAHVELAD AGQYRCAATN 2880 AAGTTQSHVL LLVQALPQIS TPPEIRVPAG SAAVFPCMAS GYPTPAITWS KVDGDLPPDS 2940 RLENNMLMLP SVRPEDAGTY VCTATNRQGK VKAFAYLQVP ERVIPYFTQT PYSFLPLPTI 3000 KDAYRKFEIK ITFRPDSADG MLLYNGQKRS PTNLANRQPD FISFGLVGGR PEFRFDAGSG 3060 MATIRHPTPL ALGQFHTVTL LRSLTQGSLI VGNLAPVNGT SQGKFQGLDL NEELYLGGYP 3120 DYGAIPKAGL SSGFVGCVRE LRIQGEEIVF HDVNLTTHGI SHCPTCQDRP CQNGGQCQDS 3180 ESSSYTCVCP AGFTAAAVNI RKPCTATPSL WADATCVNRP DGRGYTCRCH LGRSGVRCEE 3240 GVTVTTPSMS GAGSYLALPA LTNTHHELRL DVEFKPLEPN GILLFSGGKS GPVEDFVSLA 3300 MVGGHLEFRY ELGSGLAVLR SHEPLALGRW HRVSAERLNK DGSLRVDGGR PVLRSSPGKS 3360 QGLNLHTLLY LGGVEPSVQL SPATNMSAHF HGCVGEVSVN GKRLDLTYSF LGSQGVGQCY 3420 DSSPCERQPC RNGATCMPAG EYEFQCLCQD GFKGDLCEHE ENPCQLHEPC LNGGTCRGAR 3480 CLCLPGFSGP RCQQGAGYGV VESDWHPEGS GGNDAPGQYG AYFYDNGFLG LPGNSFSRSL 3540 PEVPETIEFE VRTSTADGLL LWQGVVREAS RSKDFISLGL QDGHLVFSYQ LGSGEARLVS 3600 GDPINDGEWH RITALREGQR GSIQVDGEDL VTGRSPGPNV AVNTKDIIYI GGAPDVATLT 3660 RGKFSSGITG CIKNLVLHTA RPGAPPPQPL DLQHRAQAGA NTRPCPS 3707 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002020 | protease binding | IPI |
| GO:0005509 | calcium ion binding | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0008022 | protein C-terminus binding | ISO |
| GO:0030021 | extracellular matrix structural constituent conferring compression resistance | RCA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001525 | angiogenesis | IEA |
| GO:0001958 | endochondral ossification | IMP |
| GO:0002062 | chondrocyte differentiation | IMP |
| GO:0006898 | receptor-mediated endocytosis | IGI |
| GO:0006898 | receptor-mediated endocytosis | IMP |
| GO:0007420 | brain development | IMP |
| GO:0008104 | protein localization | IMP |
| GO:0009887 | animal organ morphogenesis | IBA |
| GO:0009888 | tissue development | IBA |
| GO:0030198 | extracellular matrix organization | IMP |
| GO:0048704 | embryonic skeletal system morphogenesis | IMP |
| GO:0048738 | cardiac muscle tissue development | IMP |
| GO:0060351 | cartilage development involved in endochondral bone morphogenesis | IMP |
| GO:0060548 | negative regulation of cell death | ISO |
| GO:1905907 | negative regulation of amyloid fibril formation | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | TAS |
| GO:0005604 | basement membrane | IDA |
| GO:0005796 | Golgi lumen | TAS |
| GO:0031012 | extracellular matrix | IDA |
| GO:0062023 | collagen-containing extracellular matrix | HDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-1474228 | Degradation of the extracellular matrix | IEA |
| R-MMU-1474244 | Extracellular matrix organization | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-1630316 | Glycosaminoglycan metabolism | IEA |
| R-MMU-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | IEA |
| R-MMU-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | IEA |
| R-MMU-196854 | Metabolism of vitamins and cofactors | IEA |
| R-MMU-1971475 | A tetrasaccharide linker sequence is required for GAG synthesis | IEA |
| R-MMU-2022928 | HS-GAG biosynthesis | IEA |
| R-MMU-2024096 | HS-GAG degradation | IEA |
| R-MMU-216083 | Integrin cell surface interactions | IEA |
| R-MMU-2187338 | Visual phototransduction | IEA |
| R-MMU-3000157 | Laminin interactions | IEA |
| R-MMU-3000171 | Non-integrin membrane-ECM interactions | IEA |
| R-MMU-3000178 | ECM proteoglycans | IEA |
| R-MMU-372790 | Signaling by GPCR | IEA |
| R-MMU-388396 | GPCR downstream signalling | IEA |
| R-MMU-418594 | G alpha (i) signalling events | IEA |
| R-MMU-6806667 | Metabolism of fat-soluble vitamins | IEA |
| R-MMU-71387 | Metabolism of carbohydrates | IEA |
| R-MMU-975634 | Retinoid metabolism and transport | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0037 | Angiogenesis |
| KW-0084 | Basement membrane |
| KW-0106 | Calcium |
| KW-0903 | Direct protein sequencing |
| KW-1015 | Disulfide bond |
| KW-0245 | EGF-like domain |
| KW-0272 | Extracellular matrix |
| KW-0325 | Glycoprotein |
| KW-0357 | Heparan sulfate |
| KW-0393 | Immunoglobulin domain |
| KW-0424 | Laminin EGF-like domain |
| KW-0479 | Metal-binding |
| KW-0654 | Proteoglycan |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| InterPro ID | InterPro Term |
|---|---|
| IPR013320 | ConA-like_dom_sf |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR013106 | Ig_V-set |
| IPR002049 | Laminin_EGF |
| IPR001791 | Laminin_G |
| IPR000034 | Laminin_IV |
| IPR036055 | LDL_receptor-like_sf |
| IPR023415 | LDLR_class-A_CS |
| IPR002172 | LDrepeatLR_classA_rpt |
| IPR000082 | SEA_dom |