| Tag | Content |
|---|---|
| Uniprot ID | Q05920 |
| Entrez ID | |
| Genbank protein ID | AAA39737.1; AAH55030.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Pyruvate carboxylase, mitochondrial |
| Gene symbol | Pc |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 13525591 |
| Functional description | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. |
| Sequence | MLKFQTVRGG LRLLGVRRSS SAPVASPNVR RLEYKPIKKV MVANRGEIAI RVFRACTELG 60 IRTVAVYSEQ DTGQMHRQKA DEAYLIGRGL APVQAYLHIP DIIKVAKENG VDAVHPGYGF 120 LSERADFAQA CQDAGVRFIG PSPEVVRKMG DKVEARAIAI AAGVPVVPGT DSPISSLHEA 180 HEFSNTFGFP IIFKAAYGGG GRGMRVVHSY EELEENYTRA YSEALAAFGN GALFVEKFIE 240 KPRHIEVQIL GDQYGNILHL YERDCSIQRR HQKVVEIAPA THLDPQLRSR LTSDSVKLAK 300 QVGYENAGTV EFLVDKHGKH YFIEVNSRLQ VEHTVTEEIT DVDLVHAQIH VSEGRSLPDL 360 GLRQENIRIN GCAIQCRVTT EDPARSFQPD TGRIEVFRSG EGMGIRLDNA SAFQGAVISP 420 HYDSLLVKVI AHGKDHPTAA TKMSRALAEF RVRGVKTNIP FLQNVLNNQQ FLAGTVDTQF 480 IDENPELFQL RPAQNRAQKL LHYLGHVMVN GPTTPIPVNV SPSPVDPAVP VVPIGPPPAG 540 FRDILLREGP EGFARAVRNH QGLLLMDTTF RDAHQSLLAT RVRTHDLKKI APYVAHNFNK 600 LFSMENWGGA TFDVAMRFLY ECPWRRLQEL RELIPNIPFQ MLLRGANAVG YTNYPDNVVF 660 KFCEVAKENG MDVFRVFDSL NYLPNMLLGM EAAGSAGGVV EAAISYTGDV ADPSRTKYSL 720 EYYMGLAEEL VRAGTHILCI KDMAGLLKPA ACTMLVSSLR DRFPDLPLHI HTHDTSGAGV 780 AAMLACAQAG ADVVDVAVDS MSGMTSQPSM GALVACTKGT PLDTEVPLER VFDYSEYWEG 840 ARGLYAAFDC TATMKSGNSD VYENEIPGGQ YTNLHFQAHS MGLGSKFKEV KKAYVEANQM 900 LGDLIKVTPS SKIVGDLAQF MVQNGLSRAE AEAQAEELSF PRSVVEFLQG YIGIPHGGFP 960 EPFRSKVLKD LPRIEGRPGA SLPPLNLKEL EKDLIDRHGE EVTPEDVLSA AMYPDVFAQF 1020 KDFTATFGPL DSLNTRLFLQ GPKIAEEFEV ELERGKTLHI KALAVSDLNR AGQRQVFFEL 1080 NGQLRSILVK DTQAMKEMHF HPKALKDVKG QIGAPMPGKV IDIKVAAGDK VAKGQPLCVL 1140 SAMKMETVVT SPMEGTIRKV HVTKDMTLEG DDLILEIE 1178 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004736 | pyruvate carboxylase activity | ISO |
| GO:0004736 | pyruvate carboxylase activity | IBA |
| GO:0005524 | ATP binding | ISO |
| GO:0009374 | biotin binding | ISO |
| GO:0031406 | carboxylic acid binding | ISO |
| GO:0042802 | identical protein binding | ISO |
| GO:0046872 | metal ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006090 | pyruvate metabolic process | ISO |
| GO:0006090 | pyruvate metabolic process | IBA |
| GO:0006094 | gluconeogenesis | IEA |
| GO:0006094 | gluconeogenesis | ISO |
| GO:0006094 | gluconeogenesis | IBA |
| GO:0006107 | oxaloacetate metabolic process | ISO |
| GO:0006629 | lipid metabolic process | IEA |
| GO:0010629 | negative regulation of gene expression | ISO |
| GO:0019074 | viral RNA genome packaging | ISO |
| GO:0044791 | positive regulation by host of viral release from host cell | ISO |
| GO:0044794 | positive regulation by host of viral process | ISO |
| GO:0071073 | positive regulation of phospholipid biosynthetic process | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IBA |
| GO:0005739 | mitochondrion | ISO |
| GO:0005739 | mitochondrion | HDA |
| GO:0005739 | mitochondrion | IDA |
| GO:0005743 | mitochondrial inner membrane | HDA |
| GO:0005759 | mitochondrial matrix | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0067 | ATP-binding |
| KW-0092 | Biotin |
| KW-0312 | Gluconeogenesis |
| KW-0436 | Ligase |
| KW-0444 | Lipid biosynthesis |
| KW-0443 | Lipid metabolism |
| KW-0464 | Manganese |
| KW-0479 | Metal-binding |
| KW-0496 | Mitochondrion |
| KW-0511 | Multifunctional enzyme |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0670 | Pyruvate |
| KW-1185 | Reference proteome |
| KW-0809 | Transit peptide |
| InterPro ID | InterPro Term |
|---|---|
| IPR013785 | Aldolase_TIM |
| IPR011761 | ATP-grasp |
| IPR005481 | BC-like_N |
| IPR001882 | Biotin_BS |
| IPR011764 | Biotin_carboxylation_dom |
| IPR005482 | Biotin_COase_C |
| IPR000089 | Biotin_lipoyl |
| IPR003379 | Carboxylase_cons_dom |
| IPR005479 | CbamoylP_synth_lsu-like_ATP-bd |
| IPR016185 | PreATP-grasp_dom_sf |
| IPR000891 | PYR_CT |
| IPR005930 | Pyruv_COase |
| IPR011054 | Rudment_hybrid_motif |
| IPR011053 | Single_hybrid_motif |