Gene: Prrx2

Basic information

Tag Content
Uniprot ID Q06348; Q61651;
Entrez ID 20204
Genbank protein ID CAA32710.1; CAA37055.1;
Genbank nucleotide ID NM_009116.2
Ensembl protein ID
Ensembl nucleotide ID
Gene name Paired mesoderm homeobox protein 2
Gene symbol Prrx2
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage E12.5, E14.5
Data sources Manually collected
Reference 9729491; 9876178;
Functional description
Sequence
MDSAAAAFAL DPPAPGPGPP PAPGDCAQAR KNFSVSHLLD LEEVAAAGRR AAGPVSGPAE 60
ARVGAAREPS GGSSGTEAAP QDGDCPSPGR GTKRKKKQRR NRTTFNSSQL QALERVFERT 120
HYPDAFVREE LARRVNLSEA RVQVWFQNRR AKFRRNERAM LATRSASLLK SYGQEAAIEQ 180
PVAPRPTTMS PDYLSWPASS PYSSVPPYSP GGSSPATPGV NMANSIASLR LKAKEFSLHH 240
SQVPTVN 247

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA bindingIMP
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specificIMP
GO:0071837 HMG box domain bindingIPI

GO:Biological Process

GO ID GO Term Evidence
GO:0002053 positive regulation of mesenchymal cell proliferationIGI
GO:0030326 embryonic limb morphogenesisIGI
GO:0042472 inner ear morphogenesisIGI
GO:0042474 middle ear morphogenesisIGI
GO:0045880 positive regulation of smoothened signaling pathwayIGI
GO:0045944 positive regulation of transcription by RNA polymerase IIIMP
GO:0048701 embryonic cranial skeleton morphogenesisIGI
GO:0048704 embryonic skeletal system morphogenesisIGI
GO:0048844 artery morphogenesisIGI
GO:0051216 cartilage developmentIGI

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusIEA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
IPR043378 PRRX1/2

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2
PS50803 OAR

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain
PF03826 OAR