| Tag | Content |
|---|---|
| Uniprot ID | Q06609; B0FXP0; B2R8T6; Q6FHX9; Q6ZNA8; Q9BV60; |
| Entrez ID | 5888 |
| Genbank protein ID | BAG36283.1; ABY59731.1; EAW92432.1; AAN87149.1; EAW92435.1; CAG38796.1; BAF84658.1; AAD49705.1; BAD18467.1; AAH01459.1; EAW92434.1; BAA02962.1; AAF69145.1; BAA03189.1; |
| Genbank nucleotide ID | NM_002875.4; XM_006720626.3; NM_001164270.1; XM_011521860.2; XM_011521861.2; NM_001164269.1; XM_011521858.2; XM_011521859.2; NM_133487.3; XM_011521857.2; |
| Ensembl protein ID | ENSP00000493712; ENSP00000267868; ENSP00000406602; ENSP00000372088; ENSP00000454176; ENSP00000433924; |
| Ensembl nucleotide ID | ENSG00000051180 |
| Gene name | DNA repair protein RAD51 homolog 1 |
| Gene symbol | RAD51 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 26507587 |
| Functional description | Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028). |
| Sequence | MAMQMQLEAN ADTSVEEESF GPQPISRLEQ CGINANDVKK LEEAGFHTVE AVAYAPKKEL 60 INIKGISEAK ADKILAEAAK LVPMGFTTAT EFHQRRSEII QITTGSKELD KLLQGGIETG 120 SITEMFGEFR TGKTQICHTL AVTCQLPIDR GGGEGKAMYI DTEGTFRPER LLAVAERYGL 180 SGSDVLDNVA YARAFNTDHQ TQLLYQASAM MVESRYALLI VDSATALYRT DYSGRGELSA 240 RQMHLARFLR MLLRLADEFG VAVVITNQVV AQVDGAAMFA ADPKKPIGGN IIAHASTTRL 300 YLRKGRGETR ICKIYDSPCL PEAEAMFAIN ADGVGDAKD 339 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.