| Tag | Content |
|---|---|
| Uniprot ID | Q07687; B4DMK4; B7ZA14; |
| Entrez ID | 1746 |
| Genbank protein ID | BAH14500.1; AAA19663.1; BAG59916.1; AAH32558.1; AAB40902.1; |
| Genbank nucleotide ID | NM_004405.3 |
| Ensembl protein ID | ENSP00000446904; ENSP00000234198; |
| Ensembl nucleotide ID | ENSG00000115844 |
| Gene name | Homeobox protein DLX-2 |
| Gene symbol | DLX2 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. |
| Sequence | MTGVFDSLVA DMHSTQIAAS STYHQHQQPP SGGGAGPGGN SSSSSSLHKP QESPTLPVST 60 ATDSSYYTNQ QHPAGGGGGG GSPYAHMGSY QYQASGLNNV PYSAKSSYDL GYTAAYTSYA 120 PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK KVRKPRTIYS SFQLAALQRR FQKTQYLALP 180 ERAELAASLG LTQTQVKIWF QNRRSKFKKM WKSGEIPSEQ HPGASASPPC ASPPVSAPAS 240 WDFGVPQRMA GGGGPGSGGS GAGSSGSSPS SAASAFLGNY PWYHQTSGSA SHLQATAPLL 300 HPTQTPQPHH HHHHHGGGGA PVSAGTIF 328 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.