| Tag | Content |
|---|---|
| Uniprot ID | Q16719; B2RCZ5; D3DP79; Q6I9T2; Q9BVW3; |
| Entrez ID | 8942 |
| Genbank protein ID | EAX11600.1; EAX11601.1; EAX11599.1; AAC50650.1; CAG33704.1; BAG37742.1; AAH00879.1; |
| Genbank nucleotide ID | NM_003937.2; NM_001199241.1; XM_017005217.1; NM_001032998.1; |
| Ensembl protein ID | ENSP00000264170; ENSP00000364928; ENSP00000386731; |
| Ensembl nucleotide ID | ENSG00000115919 |
| Gene name | Kynureninase |
| Gene symbol | KYNU |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. |
| Sequence | MEPSSLELPA DTVQRIAAEL KCHPTDERVA LHLDEEDKLR HFRECFYIPK IQDLPPVDLS 60 LVNKDENAIY FLGNSLGLQP KMVKTYLEEE LDKWAKIAAY GHEVGKRPWI TGDESIVGLM 120 KDIVGANEKE IALMNALTVN LHLLMLSFFK PTPKRYKILL EAKAFPSDHY AIESQLQLHG 180 LNIEESMRMI KPREGEETLR IEDILEVIEK EGDSIAVILF SGVHFYTGQH FNIPAITKAG 240 QAKGCYVGFD LAHAVGNVEL YLHDWGVDFA CWCSYKYLNA GAGGIAGAFI HEKHAHTIKP 300 ALVGWFGHEL STRFKMDNKL QLIPGVCGFR ISNPPILLVC SLHASLEIFK QATMKALRKK 360 SVLLTGYLEY LIKHNYGKDK AATKKPVVNI ITPSHVEERG CQLTITFSVP NKDVFQELEK 420 RGVVCDKRNP NGIRVAPVPL YNSFHDVYKF TNLLTSILDS AETKN 465 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.