Gene: Tctn2

Basic information

Tag Content
Uniprot ID Q2MV57; Q6PDZ5; Q8C0B3; Q9CXF5;
Entrez ID 67978
Genbank protein ID AAH58375.1; BAB29379.1; BAC27569.1; ABB90561.1;
Genbank nucleotide ID NM_026486.3
Ensembl protein ID
Ensembl nucleotide ID
Gene name Tectonic-2
Gene symbol Tctn2
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 21565611
Functional description Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction.
Sequence
MGSLSPLSLL WGLLLLQGVL RPLRGDPVFI PPFIRMSSPE VRATLVGGSE DVAVSLSLLQ 60
VEEGVLPVPT CGGRRNETVD WNVTVSPRES TLEVTIRWKR GLDWCSADET ASFSEPPCVL 120
QMLLVSASHN ASCLAHLLIQ VEIYPNTSVT HNASENMTVI PNQVYQPLGP CPCDLTAKAC 180
DIQCCCDQDC QPEVRELFAQ SCFSGVFGGH VSPPSHHHCA VSTTHQTPDW FPLLCVQSPP 240
STSPFLGHFY HGATSPRHSP GFEAHLHFDL RDFADASYKQ GDPIMTTEGY FTIPQVSLAG 300
QCLQDAPVAF LRNFDSVCTM DLEVHQGRDE IVLENMKIRT TGGPVTPTVT YEEAIDLDKF 360
ITSPDTVLSV GSAPRNVNVE EHYVFRWQNN SISGLDITVI RAEISAQQRG MMTQRFTVKF 420
LSHHSGGEKE FSGNPGYQLG KPVRALHTAG MNVSTLHLWQ PAGRGLCTAA ALRPILFGEN 480
AFSGCLLEVG IKENCTQLRE NVLQRLDLLT QATHVARRGN SDYSDLSDGW LEIIRAEAPD 540
TGADLPLSSV NGVCPEVPAR LSIRILTAEA GSVEGVAQRE ILAVETRFST VTWQYQCGLT 600
CEDKADLLPL SASVEFINVP AQMPHPPTRF QINFTEYDCT RNELCWPQLL YPLTQYYQGE 660
PQSQCVAKGL MLLSLLMLAI LLRHPWVRMC KARDSAAIYH

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI

GO:Biological Process

GO ID GO Term Evidence
GO:0007224 smoothened signaling pathwayIMP
GO:0007224 smoothened signaling pathwayIBA
GO:0060271 cilium assemblyIMP
GO:0060271 cilium assemblyIBA
GO:1904491 protein localization to ciliary transition zoneIBA
GO:1904491 protein localization to ciliary transition zoneIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005737 cytoplasmIEA
GO:0005856 cytoskeletonIEA
GO:0016021 integral component of membraneIEA
GO:0035869 ciliary transition zoneIDA
GO:0036038 MKS complexIDA
GO:0036038 MKS complexIBA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1852241 Organelle biogenesis and maintenanceIEA
R-MMU-5617833 Cilium AssemblyIEA
R-MMU-5620912 Anchoring of the basal body to the plasma membraneIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0966 Cell projection
KW-0970 Cilium biogenesis/degradation
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0325 Glycoprotein
KW-0472 Membrane
KW-1185 Reference proteome
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR011677 DUF1619
IPR040354 Tectonic

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF07773 DUF1619

Protein-protein interaction