| Tag | Content |
|---|---|
| Uniprot ID | Q3UVD5; B2RUL8; Q80UB8; Q8R301; |
| Entrez ID | 329252 |
| Genbank protein ID | AAO85074.1; BAE23335.1; AAI41211.1; AAH26896.1; |
| Genbank nucleotide ID | NM_001033409.3 |
| Ensembl protein ID | ENSMUSP00000035444 |
| Ensembl nucleotide ID | ENSMUSG00000042793 |
| Gene name | Leucine-rich repeat-containing G-protein coupled receptor 6 |
| Gene symbol | Lgr6 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 29769720 |
| Functional description | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal (By similarity). |
| Sequence | MHSPPGLLAL WLCAVLCASA RAGSDPQPGP GRPACPAPCH CQEDGIMLSA DCSELGLSVV 60 PADLDPLTAY LDLSMNNLTE LQPGLFHHLR FLEELRLSGN HLSHIPGQAF SGLHSLKILM 120 LQSNQLRGIP AEALWELPSL QSLRLDANLI SLVPERSFEG LSSLRHLWLD DNALTEIPVR 180 ALNNLPALQA MTLALNHIRH IPDYAFQNLT SLVVLHLHNN RIQHVGTHSF EGLHNLETLD 240 LNYNELQEFP LAIRTLGRLQ ELGFHNNNIK AIPEKAFMGS PLLQTIHFYD NPIQFVGRSA 300 FQYLSKLHTL SLNGATDIQE FPDLKGTTSL EILTLTRAGI RLLPPGVCQQ LPRLRILELS 360 HNQIEELPSL HRCQKLEEIG LRHNRIKEIG ADTFSQLGSL QALDLSWNAI RAIHPEAFST 420 LRSLVKLDLT DNQLTTLPLA GLGGLMHLKL KGNLALSQAF SKDSFPKLRI LEVPYAYQCC 480 AYGICASFFK TSGQWQAEDF HPEEEEAPKR PLGLLAGQAE NHYDLDLDEL QMGTEDSKPH 540 PSVQCSPVPG PFKPCEHLFE SWGIRLAVWA IVLLSVLCNG LVLLTVFASG PSPLSPVKLV 600 VGAMAGANAL SGISCGLLAS VDALTYGQFA EYGARWESGL GCQATGFLAV LGSEASVLLL 660 TLAAVQCSIS VTCVRAYGKA PSPGSVRAGA LGCLALAGLA AALPLASVGE YGASPLCLPY 720 APPEGRPAAL GFAVALVMMN SLCFLVVAGA YIKLYCDLPR GDFEAVWDCA MVRHVAWLIF 780 ADGLLYCPVA FLSFASMLGL FPVTPEAVKS VLLVVLPLPA CLNPLLYLLF NPHFRDDLRR 840 LWPSPRSPGP LAYAAAGELE KSSCDSTQAL VAFSDVDLIL EASEAGQPPG LETYGFPSVT 900 LISRHQPGAT RLEGNHFVES DGTKFGNPQP PMKGELLLKA EGATLAGCGS SVGGALWPSG 960 SLFASHL 967 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003674 | molecular_function | ND |
| GO:0004930 | G protein-coupled receptor activity | IEA |
| GO:0016500 | protein-hormone receptor activity | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA |
| GO:0016055 | Wnt signaling pathway | IEA |
| GO:0030177 | positive regulation of Wnt signaling pathway | ISO |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0042246 | tissue regeneration | IMP |
| GO:1990523 | bone regeneration | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | IBA |
| GO:0005886 | plasma membrane | IEA |
| GO:0016021 | integral component of membrane | IEA |
| GO:0031012 | extracellular matrix | IBA |
| GO:0031982 | vesicle | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0433 | Leucine-rich repeat |
| KW-0472 | Membrane |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0879 | Wnt signaling pathway |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51450 | LRR |
| Pfam ID | Pfam Term |
|---|---|
| PF13855 | LRR_8 |