CleftGeneDB-Search

Gene: MIDN

Basic information

Tag	Content
Uniprot ID	Q504T8; Q96BW8;
Entrez ID	90007
Genbank protein ID	AAH94778.1; AAH15089.2;
Genbank nucleotide ID	NM_177401.4
Ensembl protein ID	ENSP00000467679; ENSP00000300952;
Ensembl nucleotide ID	ENSG00000167470
Gene name	Midnolin
Gene symbol	MIDN
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
Sequence	MEPQPGGARS CRRGAPGGAC ELGPAAEAAP MSLAIHSTTG TRYDLAVPPD ETVEGLRKRL 60 SQRLKVPKER LALLHKDTRL SSGKLQEFGV GDGSKLTLVP TVEAGLMSQA SRPEQSVMQA 120 LESLTETQVS DFLSGRSPLT LALRVGDHMM FVQLQLAAQH APLQHRHVLA AAAAAAAARG 180 DPSIASPVSS PCRPVSSAAR VPPVPTSPSP ASPSPITAGS FRSHAASTTC PEQMDCSPTA 240 SSSASPGAST TSTPGASPAP RSRKPGAVIE SFVNHAPGVF SGTFSGTLHP NCQDSSGRPR 300 RDIGTILQIL NDLLSATRHY QGMPPSLAQL RCHAQCSPAS PAPDLAPRTT SCEKLTAAPS 360 ASLLQGQSQI RMCKPPGDRL RQTENRATRC KVERLQLLLQ QKRLRRKARR DARGPYHWSP 420 SRKAGRSDSS SSGGGGSPSE ASGLGLDFED SVWKPEVNPD IKSEFVVA 468

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	MIDN	102189030	A0A452EXT3		Capra hircus	Prediction	More>>
1:1 ortholog	MIDN	90007	Q504T8		Homo sapiens	Prediction	More>>
1:1 ortholog	Midn	59090	Q3TPJ7	CPO	Mus musculus	Publication	More>>
1:1 ortholog	MIDN	749952	A0A2J8J273		Pan troglodytes	Prediction	More>>
1:1 ortholog	MIDN		A0A287ABE3		Sus scrofa	Prediction	More>>
1:1 ortholog	Midn	314623	D4AE48		Rattus norvegicus	Prediction	More>>
1:1 ortholog	midn	323713	Q6NYU6		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs971142541	p.Pro5Ala	missense variant	-	NC_000019.10:g.1250309C>G	TOPMed
rs971142541	p.Pro5Ser	missense variant	-	NC_000019.10:g.1250309C>T	TOPMed
rs982104669	p.Pro5Arg	missense variant	-	NC_000019.10:g.1250310C>G	TOPMed
rs1478701659	p.Gly6Asp	missense variant	-	NC_000019.10:g.1250313G>A	TOPMed
rs1181265400	p.Arg9Gly	missense variant	-	NC_000019.10:g.1250321C>G	TOPMed
rs1036893755	p.Ser10Arg	missense variant	-	NC_000019.10:g.1250326C>G	TOPMed
rs940735755	p.Ser10Asn	missense variant	-	NC_000019.10:g.1250325G>A	TOPMed,gnomAD
rs907976425	p.Ser10Gly	missense variant	-	NC_000019.10:g.1250324A>G	TOPMed
rs1176003588	p.Cys11Trp	missense variant	-	NC_000019.10:g.1250329C>G	gnomAD
rs757450452	p.Ala15Gly	missense variant	-	NC_000019.10:g.1250340C>G	ExAC,TOPMed,gnomAD
rs757450452	p.Ala15Asp	missense variant	-	NC_000019.10:g.1250340C>A	ExAC,TOPMed,gnomAD
rs757450452	p.Ala15Val	missense variant	-	NC_000019.10:g.1250340C>T	ExAC,TOPMed,gnomAD
rs919756257	p.Pro16Leu	missense variant	-	NC_000019.10:g.1250343C>T	TOPMed,gnomAD
rs1320520510	p.Pro16Ser	missense variant	-	NC_000019.10:g.1250342C>T	TOPMed
rs202070687	p.Cys20Gly	missense variant	-	NC_000019.10:g.1250354T>G	1000Genomes,ExAC,TOPMed,gnomAD
rs758754948	p.Gly23Arg	missense variant	-	NC_000019.10:g.1250363G>C	ExAC,TOPMed,gnomAD
rs758754948	p.Gly23Cys	missense variant	-	NC_000019.10:g.1250363G>T	ExAC,TOPMed,gnomAD
rs758754948	p.Gly23Ser	missense variant	-	NC_000019.10:g.1250363G>A	ExAC,TOPMed,gnomAD
rs1050117643	p.Pro24Thr	missense variant	-	NC_000019.10:g.1250366C>A	TOPMed
rs1410496610	p.Pro24Arg	missense variant	-	NC_000019.10:g.1250367C>G	gnomAD
rs752001667	p.Glu27Lys	missense variant	-	NC_000019.10:g.1250375G>A	ExAC,TOPMed,gnomAD
rs755477061	p.Glu27Ala	missense variant	-	NC_000019.10:g.1250376A>C	ExAC,gnomAD
rs1415940793	p.Ala29Thr	missense variant	-	NC_000019.10:g.1250381G>A	TOPMed
rs1312429457	p.Pro30Ser	missense variant	-	NC_000019.10:g.1250384C>T	gnomAD
rs777300728	p.Met31Ile	missense variant	-	NC_000019.10:g.1250389G>C	ExAC,TOPMed,gnomAD
rs1209656447	p.Met31Val	missense variant	-	NC_000019.10:g.1250387A>G	gnomAD
rs777300728	p.Met31Ile	missense variant	-	NC_000019.10:g.1250389G>A	ExAC,TOPMed,gnomAD
rs748774097	p.Ser32Gly	missense variant	-	NC_000019.10:g.1250390A>G	ExAC
rs770526250	p.Ser32Thr	missense variant	-	NC_000019.10:g.1250391G>C	ExAC,TOPMed,gnomAD
rs770526250	p.Ser32Asn	missense variant	-	NC_000019.10:g.1250391G>A	ExAC,TOPMed,gnomAD
rs745584780	p.Ala34Val	missense variant	-	NC_000019.10:g.1250397C>T	ExAC,gnomAD
rs775440270	p.His36Tyr	missense variant	-	NC_000019.10:g.1250402C>T	ExAC,TOPMed,gnomAD
rs368352874	p.Ser37Cys	missense variant	-	NC_000019.10:g.1250405A>T	ESP
rs768499988	p.Thr39Met	missense variant	-	NC_000019.10:g.1250412C>T	ExAC,gnomAD
rs1307423084	p.Gly40Ala	missense variant	-	NC_000019.10:g.1250415G>C	TOPMed,gnomAD
rs1430563088	p.Gly40Ser	missense variant	-	NC_000019.10:g.1250414G>A	gnomAD
rs1307423084	p.Gly40Asp	missense variant	-	NC_000019.10:g.1250415G>A	TOPMed,gnomAD
rs776678714	p.Thr41Ser	missense variant	-	NC_000019.10:g.1250418C>G	ExAC,gnomAD
rs765422422	p.Arg42His	missense variant	-	NC_000019.10:g.1250421G>A	ExAC,gnomAD
rs750594313	p.Tyr43Cys	missense variant	-	NC_000019.10:g.1250424A>G	ExAC,gnomAD
rs1300877196	p.Asp44Asn	missense variant	-	NC_000019.10:g.1250426G>A	gnomAD
rs766660331	p.Leu45Val	missense variant	-	NC_000019.10:g.1250429C>G	ExAC,TOPMed,gnomAD
rs755432431	p.Pro48Ser	missense variant	-	NC_000019.10:g.1250438C>T	ExAC,TOPMed,gnomAD
rs781531680	p.Pro49Leu	missense variant	-	NC_000019.10:g.1250442C>T	ExAC,gnomAD
rs756719134	p.Asp50Asn	missense variant	-	NC_000019.10:g.1250444G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu54Asp	missense variant	-	NC_000019.10:g.1250458G>C	NCI-TCGA
rs779945506	p.Gly55Ala	missense variant	-	NC_000019.10:g.1250460G>C	ExAC,TOPMed,gnomAD
rs779945506	p.Gly55Glu	missense variant	-	NC_000019.10:g.1250460G>A	ExAC,TOPMed,gnomAD
rs1407120806	p.Leu56Met	missense variant	-	NC_000019.10:g.1250462C>A	gnomAD
rs768534431	p.Lys58Gln	missense variant	-	NC_000019.10:g.1250468A>C	ExAC,gnomAD
rs1349796220	p.Lys58Asn	missense variant	-	NC_000019.10:g.1250470G>C	gnomAD
rs776426661	p.Arg59Trp	missense variant	-	NC_000019.10:g.1250471C>T	ExAC,gnomAD
rs769702282	p.Arg63His	missense variant	-	NC_000019.10:g.1250484G>A	ExAC,TOPMed,gnomAD
rs763117290	p.Leu64Phe	missense variant	-	NC_000019.10:g.1250486C>T	ExAC,TOPMed,gnomAD
rs1229527549	p.Lys65Asn	missense variant	-	NC_000019.10:g.1250491A>C	TOPMed,gnomAD
rs751831953	p.Val66Met	missense variant	-	NC_000019.10:g.1250492G>A	ExAC,gnomAD
rs767994744	p.Lys68Asn	missense variant	-	NC_000019.10:g.1250500G>T	ExAC,gnomAD
rs1267741866	p.Lys68Gln	missense variant	-	NC_000019.10:g.1250498A>C	TOPMed
rs759792077	p.Lys68Arg	missense variant	-	NC_000019.10:g.1250499A>G	ExAC,gnomAD
rs756660095	p.Arg70His	missense variant	-	NC_000019.10:g.1250505G>A	ExAC,gnomAD
rs746724270	p.Ala72Gly	missense variant	-	NC_000019.10:g.1250511C>G	ExAC,TOPMed,gnomAD
rs779820891	p.Ala72Thr	missense variant	-	NC_000019.10:g.1250510G>A	ExAC,TOPMed,gnomAD
rs746724270	p.Ala72Val	missense variant	-	NC_000019.10:g.1250511C>T	ExAC,TOPMed,gnomAD
rs754714322	p.Leu73Val	missense variant	-	NC_000019.10:g.1250513C>G	ExAC,TOPMed,gnomAD
rs1241748417	p.Leu74Phe	missense variant	-	NC_000019.10:g.1250516C>T	TOPMed
rs781052615	p.Asp77Glu	missense variant	-	NC_000019.10:g.1250527C>A	ExAC,TOPMed,gnomAD
rs1389895531	p.Thr78Asn	missense variant	-	NC_000019.10:g.1250529C>A	TOPMed,gnomAD
rs1389895531	p.Thr78Ile	missense variant	-	NC_000019.10:g.1250529C>T	TOPMed,gnomAD
rs770442876	p.Ser81Asn	missense variant	-	NC_000019.10:g.1251570G>A	ExAC,gnomAD
rs1461023008	p.Ser82Leu	missense variant	-	NC_000019.10:g.1251573C>T	gnomAD
rs767007304	p.Lys84Arg	missense variant	-	NC_000019.10:g.1251579A>G	ExAC,gnomAD
rs375683589	p.Lys84Asn	missense variant	-	NC_000019.10:g.1251580G>C	ESP,ExAC,gnomAD
NCI-TCGA novel	p.Leu85ProPheSerTerUnk	frameshift	-	NC_000019.10:g.1251580_1251581insC	NCI-TCGA
rs1296528392	p.Phe88Cys	missense variant	-	NC_000019.10:g.1251591T>G	gnomAD
rs1225321020	p.Gly89Ser	missense variant	-	NC_000019.10:g.1251593G>A	gnomAD
rs144043116	p.Gly91Cys	missense variant	-	NC_000019.10:g.1251599G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs778888633	p.Gly91Asp	missense variant	-	NC_000019.10:g.1251600G>A	ExAC,gnomAD
rs778888633	p.Gly91Val	missense variant	-	NC_000019.10:g.1251600G>T	ExAC,gnomAD
rs1270299097	p.Asp92Val	missense variant	-	NC_000019.10:g.1251603A>T	gnomAD
rs758491546	p.Ser94Thr	missense variant	-	NC_000019.10:g.1251609G>C	ExAC,gnomAD
COSM1390510	p.Ser94Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000019.10:g.1251610C>A	NCI-TCGA Cosmic
rs1167616422	p.Glu103Ter	stop gained	-	NC_000019.10:g.1251635G>T	gnomAD
rs1290717832	p.Met107Thr	missense variant	-	NC_000019.10:g.1251648T>C	TOPMed
rs745951617	p.Met107Val	missense variant	-	NC_000019.10:g.1251647A>G	ExAC,gnomAD
rs779362405	p.Ser108Tyr	missense variant	-	NC_000019.10:g.1251840C>A	ExAC,TOPMed,gnomAD
rs779362405	p.Ser108Phe	missense variant	-	NC_000019.10:g.1251840C>T	ExAC,TOPMed,gnomAD
rs779362405	p.Ser108Cys	missense variant	-	NC_000019.10:g.1251840C>G	ExAC,TOPMed,gnomAD
rs1371697914	p.Gln109Pro	missense variant	-	NC_000019.10:g.1251843A>C	TOPMed,gnomAD
rs1346880159	p.Gln109Glu	missense variant	-	NC_000019.10:g.1251842C>G	gnomAD
rs1371697914	p.Gln109Arg	missense variant	-	NC_000019.10:g.1251843A>G	TOPMed,gnomAD
rs746431075	p.Ala110Val	missense variant	-	NC_000019.10:g.1251846C>T	ExAC,TOPMed,gnomAD
rs1221286491	p.Ala110Thr	missense variant	-	NC_000019.10:g.1251845G>A	gnomAD
rs1221286491	p.Ala110Ser	missense variant	-	NC_000019.10:g.1251845G>T	gnomAD
rs776121596	p.Ser111Leu	missense variant	-	NC_000019.10:g.1251849C>T	ExAC,TOPMed,gnomAD
rs769350537	p.Arg112Ser	missense variant	-	NC_000019.10:g.1251853G>T	ExAC,TOPMed,gnomAD
rs759296354	p.Arg112Lys	missense variant	-	NC_000019.10:g.1251852G>A	ExAC,TOPMed,gnomAD
rs1205185771	p.Pro113Ser	missense variant	-	NC_000019.10:g.1251854C>T	gnomAD
rs762620482	p.Pro113Arg	missense variant	-	NC_000019.10:g.1251855C>G	ExAC,TOPMed,gnomAD
rs762620482	p.Pro113Leu	missense variant	-	NC_000019.10:g.1251855C>T	ExAC,TOPMed,gnomAD
rs377700904	p.Gln115His	missense variant	-	NC_000019.10:g.1251862G>C	ESP,ExAC,TOPMed,gnomAD
rs375835337	p.Val117Leu	missense variant	-	NC_000019.10:g.1251866G>C	ESP,ExAC,TOPMed,gnomAD
rs375835337	p.Val117Leu	missense variant	-	NC_000019.10:g.1251866G>T	ESP,ExAC,TOPMed,gnomAD
rs945811171	p.Met118Leu	missense variant	-	NC_000019.10:g.1251869A>T	TOPMed
rs1278177515	p.Gln119Ter	stop gained	-	NC_000019.10:g.1251872C>T	gnomAD
rs757558824	p.Leu121Val	missense variant	-	NC_000019.10:g.1251878C>G	ExAC,gnomAD
rs758934723	p.Glu122Gln	missense variant	-	NC_000019.10:g.1251881G>C	ExAC,TOPMed,gnomAD
rs747586153	p.Thr127Lys	missense variant	-	NC_000019.10:g.1251897C>A	ExAC,TOPMed,gnomAD
rs747586153	p.Thr127Arg	missense variant	-	NC_000019.10:g.1251897C>G	ExAC,TOPMed,gnomAD
rs747586153	p.Thr127Met	missense variant	-	NC_000019.10:g.1251897C>T	ExAC,TOPMed,gnomAD
rs1264499113	p.Val129Ile	missense variant	-	NC_000019.10:g.1254167G>A	gnomAD
rs1461310491	p.Ser130Gly	missense variant	-	NC_000019.10:g.1254170A>G	gnomAD
rs1261868352	p.Phe132Leu	missense variant	-	NC_000019.10:g.1254178C>A	gnomAD
rs781181977	p.Leu133Val	missense variant	-	NC_000019.10:g.1254179C>G	ExAC,TOPMed,gnomAD
rs748137724	p.Ser134Leu	missense variant	-	NC_000019.10:g.1254183C>T	ExAC,TOPMed,gnomAD
rs1475414307	p.Gly135Asp	missense variant	-	NC_000019.10:g.1254186G>A	gnomAD
rs540283060	p.Arg136Gly	missense variant	-	NC_000019.10:g.1254188C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs777832041	p.Arg136His	missense variant	-	NC_000019.10:g.1254189G>A	ExAC,TOPMed,gnomAD
rs540283060	p.Arg136Cys	missense variant	-	NC_000019.10:g.1254188C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs749475160	p.Ser137Trp	missense variant	-	NC_000019.10:g.1254192C>G	ExAC,gnomAD
rs1201843362	p.Thr140Ile	missense variant	-	NC_000019.10:g.1254201C>T	TOPMed
rs761280459	p.Asp147Asn	missense variant	-	NC_000019.10:g.1254221G>A	ExAC,TOPMed,gnomAD
rs367835894	p.Met149Val	missense variant	-	NC_000019.10:g.1254227A>G	ESP,ExAC,TOPMed,gnomAD
rs762418714	p.Met150Ile	missense variant	-	NC_000019.10:g.1254232G>A	ExAC,gnomAD
rs766023183	p.Phe151Leu	missense variant	-	NC_000019.10:g.1254235C>A	ExAC,gnomAD
rs1259544499	p.Val152Met	missense variant	-	NC_000019.10:g.1254236G>A	TOPMed,gnomAD
rs1186999767	p.Gln155His	missense variant	-	NC_000019.10:g.1254247G>T	gnomAD
rs754784777	p.Leu156Val	missense variant	-	NC_000019.10:g.1254248C>G	ExAC,gnomAD
rs766611057	p.Ala157Ser	missense variant	-	NC_000019.10:g.1254251G>T	ExAC,TOPMed,gnomAD
rs766611057	p.Ala157Thr	missense variant	-	NC_000019.10:g.1254251G>A	ExAC,TOPMed,gnomAD
rs1417945925	p.Ala158Thr	missense variant	-	NC_000019.10:g.1254254G>A	gnomAD
rs1301581173	p.Ala161Val	missense variant	-	NC_000019.10:g.1254264C>T	gnomAD
rs1030971122	p.Ala161Thr	missense variant	-	NC_000019.10:g.1254263G>A	TOPMed,gnomAD
rs1302167084	p.Leu163Arg	missense variant	-	NC_000019.10:g.1254270T>G	TOPMed
rs770960950	p.Gln164Leu	missense variant	-	NC_000019.10:g.1254273A>T	ExAC,gnomAD
rs1224677681	p.His165Arg	missense variant	-	NC_000019.10:g.1254276A>G	TOPMed,gnomAD
rs779192162	p.Arg166Gly	missense variant	-	NC_000019.10:g.1254278C>G	ExAC,gnomAD
rs956082972	p.Arg166His	missense variant	-	NC_000019.10:g.1254279G>A	TOPMed
rs929315605	p.Val168Ala	missense variant	-	NC_000019.10:g.1254285T>C	TOPMed,gnomAD
rs761213192	p.Ala170Thr	missense variant	-	NC_000019.10:g.1254290G>A	ExAC,gnomAD
rs769262895	p.Ala171Thr	missense variant	-	NC_000019.10:g.1254293G>A	ExAC,TOPMed,gnomAD
rs769262895	p.Ala171Ser	missense variant	-	NC_000019.10:g.1254293G>T	ExAC,TOPMed,gnomAD
rs765860661	p.Ala172Pro	missense variant	-	NC_000019.10:g.1254296G>C	ExAC,gnomAD
rs1237817278	p.Ala172Val	missense variant	-	NC_000019.10:g.1254297C>T	gnomAD
rs759111690	p.Ala174Thr	missense variant	-	NC_000019.10:g.1254302G>A	ExAC,TOPMed,gnomAD
rs201144803	p.Ala175Thr	missense variant	-	NC_000019.10:g.1254305G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs777660170	p.Ala176Thr	missense variant	-	NC_000019.10:g.1254308G>A	ExAC,TOPMed,gnomAD
rs1444179233	p.Ala177Val	missense variant	-	NC_000019.10:g.1254312C>T	gnomAD
rs1375729783	p.Ala177Thr	missense variant	-	NC_000019.10:g.1254311G>A	gnomAD
rs757347314	p.Ala178Val	missense variant	-	NC_000019.10:g.1254315C>T	ExAC,TOPMed,gnomAD
rs1305151140	p.Ala178Thr	missense variant	-	NC_000019.10:g.1254314G>A	gnomAD
rs562824172	p.Arg179Pro	missense variant	-	NC_000019.10:g.1254318G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs562824172	p.Arg179Gln	missense variant	-	NC_000019.10:g.1254318G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1338724071	p.Arg179Trp	missense variant	-	NC_000019.10:g.1254317C>T	TOPMed
rs758580814	p.Gly180Glu	missense variant	-	NC_000019.10:g.1254321G>A	ExAC,TOPMed,gnomAD
rs1195796182	p.Asp181Asn	missense variant	-	NC_000019.10:g.1254323G>A	TOPMed,gnomAD
rs368475536	p.Asp181Val	missense variant	-	NC_000019.10:g.1254324A>T	ESP
rs1195796182	p.Asp181Tyr	missense variant	-	NC_000019.10:g.1254323G>T	TOPMed,gnomAD
NCI-TCGA novel	p.Asp181GlyPheSerTerUnk	frameshift	-	NC_000019.10:g.1254317_1254318insGG	NCI-TCGA
rs780471332	p.Ser183Asn	missense variant	-	NC_000019.10:g.1254330G>A	ExAC,TOPMed,gnomAD
rs780471332	p.Ser183Thr	missense variant	-	NC_000019.10:g.1254330G>C	ExAC,TOPMed,gnomAD
rs747345791	p.Ile184Met	missense variant	-	NC_000019.10:g.1254334A>G	ExAC,gnomAD
rs1052046589	p.Ala185Thr	missense variant	-	NC_000019.10:g.1254335G>A	TOPMed
rs1410976374	p.Ser186Phe	missense variant	-	NC_000019.10:g.1254339C>T	TOPMed,gnomAD
rs1327585655	p.Val188Glu	missense variant	-	NC_000019.10:g.1254345T>A	gnomAD
rs748612554	p.Val188Met	missense variant	-	NC_000019.10:g.1254344G>A	ExAC,TOPMed,gnomAD
rs748612554	p.Val188Leu	missense variant	-	NC_000019.10:g.1254344G>T	ExAC,TOPMed,gnomAD
rs748612554	p.Val188Leu	missense variant	-	NC_000019.10:g.1254344G>C	ExAC,TOPMed,gnomAD
COSM2815886	p.Val188CysPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000019.10:g.1254339C>-	NCI-TCGA Cosmic
rs770403819	p.Ser189Phe	missense variant	-	NC_000019.10:g.1254348C>T	ExAC,gnomAD
rs759182331	p.Ser190Leu	missense variant	-	NC_000019.10:g.1254351C>T	ExAC,TOPMed,gnomAD
rs375261373	p.Cys192Phe	missense variant	-	NC_000019.10:g.1254357G>T	ESP,ExAC,TOPMed,gnomAD
rs375261373	p.Cys192Tyr	missense variant	-	NC_000019.10:g.1254357G>A	ESP,ExAC,TOPMed,gnomAD
rs751831100	p.Cys192Trp	missense variant	-	NC_000019.10:g.1254358C>G	gnomAD
rs201314448	p.Arg193Gln	missense variant	-	NC_000019.10:g.1254360G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs753752976	p.Arg193Trp	missense variant	-	NC_000019.10:g.1254359C>T	ExAC,gnomAD
rs765322691	p.Pro194Leu	missense variant	-	NC_000019.10:g.1254363C>T	ExAC,TOPMed,gnomAD
rs1451199531	p.Pro194Ser	missense variant	-	NC_000019.10:g.1254362C>T	gnomAD
rs1451199531	p.Pro194Ala	missense variant	-	NC_000019.10:g.1254362C>G	gnomAD
rs372950930	p.Val195Leu	missense variant	-	NC_000019.10:g.1254365G>T	ESP,ExAC,TOPMed,gnomAD
rs372950930	p.Val195Leu	missense variant	-	NC_000019.10:g.1254365G>C	ESP,ExAC,TOPMed,gnomAD
rs1425659993	p.Ser196Phe	missense variant	-	NC_000019.10:g.1254369C>T	TOPMed
rs1367900582	p.Ala198Val	missense variant	-	NC_000019.10:g.1254375C>T	TOPMed
rs377245188	p.Ala199Thr	missense variant	-	NC_000019.10:g.1254377G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs748646040	p.Ala199Val	missense variant	-	NC_000019.10:g.1254378C>T	ExAC,TOPMed,gnomAD
rs755188181	p.Arg200Gln	missense variant	-	NC_000019.10:g.1254381G>A	ExAC,TOPMed,gnomAD
rs771641098	p.Pro202Leu	missense variant	-	NC_000019.10:g.1254387C>T	ExAC,gnomAD
rs369043794	p.Pro202Ser	missense variant	-	NC_000019.10:g.1254386C>T	ESP,ExAC,TOPMed,gnomAD
rs373111260	p.Pro203Leu	missense variant	-	NC_000019.10:g.1254390C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs373111260	p.Pro203Arg	missense variant	-	NC_000019.10:g.1254390C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Val204GlyPheSerTerUnkUnk	frameshift	-	NC_000019.10:g.1254384_1254385insC	NCI-TCGA
rs1283703268	p.Val204Gly	missense variant	-	NC_000019.10:g.1254393T>G	TOPMed
rs371141933	p.Pro205Ser	missense variant	-	NC_000019.10:g.1254395C>T	ESP
rs1215725627	p.Pro205Leu	missense variant	-	NC_000019.10:g.1254396C>T	TOPMed
rs941670480	p.Thr206Pro	missense variant	-	NC_000019.10:g.1254398A>C	TOPMed,gnomAD
rs941670480	p.Thr206Ala	missense variant	-	NC_000019.10:g.1254398A>G	TOPMed,gnomAD
rs556584144	p.Thr206Ile	missense variant	-	NC_000019.10:g.1254399C>T	gnomAD
rs556584144	p.Thr206Asn	missense variant	-	NC_000019.10:g.1254399C>A	gnomAD
rs376802436	p.Pro208Gln	missense variant	-	NC_000019.10:g.1254405C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs376802436	p.Pro208Leu	missense variant	-	NC_000019.10:g.1254405C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1447725798	p.Ser209Tyr	missense variant	-	NC_000019.10:g.1254408C>A	gnomAD
rs1300816776	p.Ser209Pro	missense variant	-	NC_000019.10:g.1254407T>C	TOPMed
rs371111878	p.Pro210Leu	missense variant	-	NC_000019.10:g.1254411C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1419568914	p.Pro213Arg	missense variant	-	NC_000019.10:g.1254420C>G	TOPMed
rs1189136661	p.Pro213Ser	missense variant	-	NC_000019.10:g.1254419C>T	gnomAD
rs1368295962	p.Ser214Leu	missense variant	-	NC_000019.10:g.1254423C>T	TOPMed,gnomAD
rs1161164175	p.Pro215Leu	missense variant	-	NC_000019.10:g.1254426C>T	gnomAD
rs781569306	p.Gly219Cys	missense variant	-	NC_000019.10:g.1254437G>T	ExAC,TOPMed,gnomAD
rs752984194	p.Gly219Val	missense variant	-	NC_000019.10:g.1254438G>T	ExAC,gnomAD
rs781569306	p.Gly219Ser	missense variant	-	NC_000019.10:g.1254437G>A	ExAC,TOPMed,gnomAD
rs781569306	p.Gly219Arg	missense variant	-	NC_000019.10:g.1254437G>C	ExAC,TOPMed,gnomAD
rs550865023	p.Arg222Leu	missense variant	-	NC_000019.10:g.1254447G>T	1000Genomes,ExAC,gnomAD
rs550865023	p.Arg222Pro	missense variant	-	NC_000019.10:g.1254447G>C	1000Genomes,ExAC,gnomAD
rs550865023	p.Arg222Gln	missense variant	-	NC_000019.10:g.1254447G>A	1000Genomes,ExAC,gnomAD
rs1339718301	p.Arg222Trp	missense variant	-	NC_000019.10:g.1254446C>T	TOPMed,gnomAD
rs1351601882	p.Ala225Thr	missense variant	-	NC_000019.10:g.1254455G>A	gnomAD
rs779545651	p.Thr228Ala	missense variant	-	NC_000019.10:g.1254464A>G	ExAC,TOPMed,gnomAD
rs746625320	p.Thr229Asn	missense variant	-	NC_000019.10:g.1254468C>A	ExAC,TOPMed,gnomAD
rs746625320	p.Thr229Ile	missense variant	-	NC_000019.10:g.1254468C>T	ExAC,TOPMed,gnomAD
rs1350107810	p.Thr229Ala	missense variant	-	NC_000019.10:g.1254467A>G	gnomAD
rs1441053430	p.Cys230Phe	missense variant	-	NC_000019.10:g.1254471G>T	gnomAD
rs761507139	p.Pro231Leu	missense variant	-	NC_000019.10:g.1254474C>T	ExAC,TOPMed,gnomAD
rs1234273229	p.Pro231Ala	missense variant	-	NC_000019.10:g.1254473C>G	gnomAD
rs761507139	p.Pro231Arg	missense variant	-	NC_000019.10:g.1254474C>G	ExAC,TOPMed,gnomAD
rs769687325	p.Glu232Asp	missense variant	-	NC_000019.10:g.1254478G>T	ExAC,gnomAD
rs951155864	p.Glu232Lys	missense variant	-	NC_000019.10:g.1254476G>A	TOPMed,gnomAD
rs951155864	p.Glu232Gln	missense variant	-	NC_000019.10:g.1254476G>C	TOPMed,gnomAD
rs759685503	p.Gln233Glu	missense variant	-	NC_000019.10:g.1254902C>G	ExAC,TOPMed,gnomAD
rs759685503	p.Gln233Lys	missense variant	-	NC_000019.10:g.1254902C>A	ExAC,TOPMed,gnomAD
rs369485715	p.Met234Ile	missense variant	-	NC_000019.10:g.1254907G>A	ESP,ExAC,TOPMed,gnomAD
rs767695604	p.Met234Thr	missense variant	-	NC_000019.10:g.1254906T>C	ExAC,gnomAD
rs1177041836	p.Asp235Asn	missense variant	-	NC_000019.10:g.1254908G>A	gnomAD
rs760959993	p.Cys236Arg	missense variant	-	NC_000019.10:g.1254911T>C	ExAC,gnomAD
rs796369265	p.Cys236Ser	missense variant	-	NC_000019.10:g.1254912G>C	TOPMed
rs1383990322	p.Pro238Leu	missense variant	-	NC_000019.10:g.1254918C>T	gnomAD
rs754226865	p.Pro238Ala	missense variant	-	NC_000019.10:g.1254917C>G	ExAC,gnomAD
rs754226865	p.Pro238Ser	missense variant	-	NC_000019.10:g.1254917C>T	ExAC,gnomAD
rs765726789	p.Thr239Met	missense variant	-	NC_000019.10:g.1254921C>T	ExAC,TOPMed,gnomAD
rs765726789	p.Thr239Lys	missense variant	-	NC_000019.10:g.1254921C>A	ExAC,TOPMed,gnomAD
COSM6083752	p.Thr239Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000019.10:g.1254920A>T	NCI-TCGA Cosmic
rs369167917	p.Ser241Asn	missense variant	-	NC_000019.10:g.1254927G>A	ESP,gnomAD
rs140723918	p.Ser241Arg	missense variant	-	NC_000019.10:g.1254928C>A	ESP,ExAC,TOPMed,gnomAD
rs1487220554	p.Ser242Arg	missense variant	-	NC_000019.10:g.1254931C>G	gnomAD
rs1223047634	p.Ser243Thr	missense variant	-	NC_000019.10:g.1254933G>C	TOPMed
NCI-TCGA novel	p.Ser243Asn	missense variant	-	NC_000019.10:g.1254933G>A	NCI-TCGA
rs755812511	p.Pro246Arg	missense variant	-	NC_000019.10:g.1254942C>G	ExAC,TOPMed,gnomAD
rs755812511	p.Pro246Leu	missense variant	-	NC_000019.10:g.1254942C>T	ExAC,TOPMed,gnomAD
rs749058593	p.Gly247Cys	missense variant	-	NC_000019.10:g.1254944G>T	ExAC,gnomAD
rs760344668	p.Gly247Ala	missense variant	-	NC_000019.10:g.1254945G>C	gnomAD
rs774418163	p.Ala248Thr	missense variant	-	NC_000019.10:g.1254947G>A	ExAC,gnomAD
rs149674816	p.Ala248Val	missense variant	-	NC_000019.10:g.1254948C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs771979004	p.Ser249Asn	missense variant	-	NC_000019.10:g.1254951G>A	ExAC,gnomAD
rs775674509	p.Thr250Ala	missense variant	-	NC_000019.10:g.1254953A>G	ExAC,gnomAD
rs145605347	p.Thr251Arg	missense variant	-	NC_000019.10:g.1254957C>G	ESP,ExAC,TOPMed,gnomAD
rs145605347	p.Thr251Met	missense variant	-	NC_000019.10:g.1254957C>T	ESP,ExAC,TOPMed,gnomAD
rs1315330602	p.Ser252Cys	missense variant	-	NC_000019.10:g.1254960C>G	gnomAD
rs372488115	p.Ser252Pro	missense variant	-	NC_000019.10:g.1254959T>C	ESP,ExAC,TOPMed,gnomAD
rs762150212	p.Thr253Ser	missense variant	-	NC_000019.10:g.1254962A>T	ExAC,gnomAD
rs750859694	p.Ser257Arg	missense variant	-	NC_000019.10:g.1254976C>G	ExAC,gnomAD
rs141486022	p.Ser257Asn	missense variant	-	NC_000019.10:g.1254975G>A	ESP
COSM3528748	p.Pro258Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000019.10:g.1254978C>T	NCI-TCGA Cosmic
rs758975948	p.Ala259Val	missense variant	-	NC_000019.10:g.1254981C>T	ExAC,TOPMed,gnomAD
rs758975948	p.Ala259Asp	missense variant	-	NC_000019.10:g.1254981C>A	ExAC,TOPMed,gnomAD
rs776406415	p.Arg261Gly	missense variant	-	NC_000019.10:g.1254986C>G	ExAC,TOPMed,gnomAD
rs776406415	p.Arg261Cys	missense variant	-	NC_000019.10:g.1254986C>T	ExAC,TOPMed,gnomAD
rs1239127438	p.Arg261His	missense variant	-	NC_000019.10:g.1254987G>A	TOPMed,gnomAD
COSM1390515	p.Arg261AlaPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000019.10:g.1254981C>-	NCI-TCGA Cosmic
rs777565691	p.Ser262Phe	missense variant	-	NC_000019.10:g.1254990C>T	ExAC,gnomAD
rs571984011	p.Arg263Gln	missense variant	-	NC_000019.10:g.1254993G>A	1000Genomes,ExAC,gnomAD
rs778856412	p.Pro265Arg	missense variant	-	NC_000019.10:g.1254999C>G	ExAC,gnomAD
rs772073371	p.Gly266Ser	missense variant	-	NC_000019.10:g.1255001G>A	ExAC,gnomAD
rs138120774	p.Val268Ile	missense variant	-	NC_000019.10:g.1255007G>A	ESP,ExAC,TOPMed,gnomAD
rs917487436	p.Glu270Lys	missense variant	-	NC_000019.10:g.1255013G>A	TOPMed,gnomAD
COSM991290	p.Glu270Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000019.10:g.1255013G>T	NCI-TCGA Cosmic
rs950121331	p.Phe272Leu	missense variant	-	NC_000019.10:g.1255019T>C	TOPMed,gnomAD
rs773648336	p.His275Gln	missense variant	-	NC_000019.10:g.1255030C>A	ExAC,TOPMed,gnomAD
rs560928353	p.His275Tyr	missense variant	-	NC_000019.10:g.1255028C>T	gnomAD
rs766876307	p.Ala276Thr	missense variant	-	NC_000019.10:g.1255031G>A	ExAC,gnomAD
rs752070614	p.Ala276Gly	missense variant	-	NC_000019.10:g.1255032C>G	ExAC,gnomAD
COSM709966	p.Ala276Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000019.10:g.1255031G>T	NCI-TCGA Cosmic
rs760220991	p.Pro277Leu	missense variant	-	NC_000019.10:g.1255035C>T	ExAC,gnomAD
COSM6149617	p.Gly278Trp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000019.10:g.1255037G>T	NCI-TCGA Cosmic
rs753475621	p.Val279Ile	missense variant	-	NC_000019.10:g.1255040G>A	ExAC,TOPMed,gnomAD
rs778805669	p.Ser281Ter	stop gained	-	NC_000019.10:g.1255047C>G	ExAC,TOPMed,gnomAD
rs778805669	p.Ser281Leu	missense variant	-	NC_000019.10:g.1255047C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gly282Arg	missense variant	-	NC_000019.10:g.1255049G>A	NCI-TCGA
rs899672358	p.Thr283Ile	missense variant	-	NC_000019.10:g.1255053C>T	TOPMed
rs750214013	p.Ser285Cys	missense variant	-	NC_000019.10:g.1255059C>G	ExAC,TOPMed,gnomAD
rs750214013	p.Ser285Phe	missense variant	-	NC_000019.10:g.1255059C>T	ExAC,TOPMed,gnomAD
rs756131224	p.Thr287Met	missense variant	-	NC_000019.10:g.1255425C>T	ExAC,TOPMed,gnomAD
rs749487603	p.Leu288Pro	missense variant	-	NC_000019.10:g.1255428T>C	ExAC,gnomAD
rs1472282455	p.His289Gln	missense variant	-	NC_000019.10:g.1255432C>A	gnomAD
rs1054118396	p.His289Tyr	missense variant	-	NC_000019.10:g.1255430C>T	TOPMed,gnomAD
rs1419768768	p.Asn291Ser	missense variant	-	NC_000019.10:g.1255437A>G	gnomAD
rs1381684807	p.Asn291Asp	missense variant	-	NC_000019.10:g.1255436A>G	gnomAD
rs1382620894	p.Cys292Trp	missense variant	-	NC_000019.10:g.1255441C>G	gnomAD
rs1415982338	p.Gln293Glu	missense variant	-	NC_000019.10:g.1255442C>G	gnomAD
NCI-TCGA novel	p.Gln293Leu	missense variant	-	NC_000019.10:g.1255443A>T	NCI-TCGA
rs948691530	p.Asp294Asn	missense variant	-	NC_000019.10:g.1255445G>A	TOPMed,gnomAD
rs948691530	p.Asp294His	missense variant	-	NC_000019.10:g.1255445G>C	TOPMed,gnomAD
rs1450791583	p.Ser295Gly	missense variant	-	NC_000019.10:g.1255448A>G	TOPMed,gnomAD
rs757443719	p.Ser295Asn	missense variant	-	NC_000019.10:g.1255449G>A	ExAC,gnomAD
rs1377830878	p.Ser295Arg	missense variant	-	NC_000019.10:g.1255450C>A	gnomAD
rs746209008	p.Gly297Arg	missense variant	-	NC_000019.10:g.1255454G>A	ExAC,gnomAD
rs143719550	p.Arg298Gln	missense variant	-	NC_000019.10:g.1255458G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs370103542	p.Arg298Trp	missense variant	-	NC_000019.10:g.1255457C>T	ESP,ExAC,TOPMed,gnomAD
rs747519561	p.Pro299Leu	missense variant	-	NC_000019.10:g.1255461C>T	ExAC,gnomAD
rs769305020	p.Arg300Trp	missense variant	-	NC_000019.10:g.1255463C>T	ExAC,TOPMed,gnomAD
rs1439787680	p.Arg300Gln	missense variant	-	NC_000019.10:g.1255464G>A	gnomAD
rs762569175	p.Arg301His	missense variant	-	NC_000019.10:g.1255467G>A	ExAC,TOPMed,gnomAD
rs1362021177	p.Arg301Cys	missense variant	-	NC_000019.10:g.1255466C>T	gnomAD
rs1362021177	p.Arg301Ser	missense variant	-	NC_000019.10:g.1255466C>A	gnomAD
rs774057147	p.Ile303Val	missense variant	-	NC_000019.10:g.1255472A>G	ExAC,gnomAD
rs752565935	p.Gly304Asp	missense variant	-	NC_000019.10:g.1255476G>A	ExAC,gnomAD
rs369704822	p.Gly304Ser	missense variant	-	NC_000019.10:g.1255475G>A	ESP,ExAC,TOPMed,gnomAD
rs368745605	p.Ile306Val	missense variant	-	NC_000019.10:g.1255481A>G	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gln308Pro	missense variant	-	NC_000019.10:g.1255488A>C	NCI-TCGA
rs907385547	p.Ile309Met	missense variant	-	NC_000019.10:g.1255492C>G	TOPMed,gnomAD
rs1004318853	p.Asp312Glu	missense variant	-	NC_000019.10:g.1255501C>A	TOPMed,gnomAD
rs1343315031	p.Asp312Asn	missense variant	-	NC_000019.10:g.1255499G>A	gnomAD
rs746153442	p.Ala316Thr	missense variant	-	NC_000019.10:g.1255511G>A	ExAC,gnomAD
rs901299658	p.Arg318Trp	missense variant	-	NC_000019.10:g.1255517C>T	TOPMed,gnomAD
rs758781666	p.Arg318Gln	missense variant	-	NC_000019.10:g.1255518G>A	ExAC,TOPMed,gnomAD
rs148123521	p.His319Arg	missense variant	-	NC_000019.10:g.1255521A>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs747466564	p.His319Tyr	missense variant	-	NC_000019.10:g.1255520C>T	ExAC,gnomAD
rs1393051918	p.Gly322Ser	missense variant	-	NC_000019.10:g.1255529G>A	gnomAD
rs770532270	p.Pro324His	missense variant	-	NC_000019.10:g.1255536C>A	ExAC,gnomAD
rs1156414180	p.Pro325Ser	missense variant	-	NC_000019.10:g.1255538C>T	TOPMed
rs1220880950	p.Pro325Leu	missense variant	-	NC_000019.10:g.1255539C>T	gnomAD
rs1418165624	p.Ser326Leu	missense variant	-	NC_000019.10:g.1255542C>T	TOPMed
rs775287482	p.Ala328Gly	missense variant	-	NC_000019.10:g.1255548C>G	ExAC,gnomAD
rs775287482	p.Ala328Val	missense variant	-	NC_000019.10:g.1255548C>T	ExAC,gnomAD
rs372010057	p.Gln329His	missense variant	-	NC_000019.10:g.1255552G>T	ESP,ExAC,TOPMed,gnomAD
rs753884875	p.Arg331His	missense variant	-	NC_000019.10:g.1255557G>A	ExAC,TOPMed,gnomAD
rs763911167	p.Arg331Cys	missense variant	-	NC_000019.10:g.1255556C>T	ExAC,gnomAD
rs61742309	p.His333Gln	missense variant	-	NC_000019.10:g.1255564C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs61742309	p.His333Gln	missense variant	-	NC_000019.10:g.1255564C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs758714390	p.Ala334Ser	missense variant	-	NC_000019.10:g.1255565G>T	ExAC,TOPMed,gnomAD
rs758714390	p.Ala334Thr	missense variant	-	NC_000019.10:g.1255565G>A	ExAC,TOPMed,gnomAD
rs751836719	p.Gln335Arg	missense variant	-	NC_000019.10:g.1255569A>G	ExAC,gnomAD
rs1477368148	p.Gln335His	missense variant	-	NC_000019.10:g.1255570G>C	gnomAD
rs1231030612	p.Cys336Tyr	missense variant	-	NC_000019.10:g.1255572G>A	gnomAD
rs150627531	p.Ser337Pro	missense variant	-	NC_000019.10:g.1255574T>C	ESP,ExAC,TOPMed,gnomAD
rs150627531	p.Ser337Thr	missense variant	-	NC_000019.10:g.1255574T>A	ESP,ExAC,TOPMed,gnomAD
rs368341629	p.Pro338Leu	missense variant	-	NC_000019.10:g.1255578C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs368341629	p.Pro338Gln	missense variant	-	NC_000019.10:g.1255578C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs368341629	p.Pro338Arg	missense variant	-	NC_000019.10:g.1255578C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1299332312	p.Ala339Val	missense variant	-	NC_000019.10:g.1255581C>T	gnomAD
rs1380821444	p.Ser340Leu	missense variant	-	NC_000019.10:g.1255584C>T	TOPMed,gnomAD
rs916497220	p.Pro341Leu	missense variant	-	NC_000019.10:g.1255587C>T	TOPMed,gnomAD
rs745476081	p.Pro341Ser	missense variant	-	NC_000019.10:g.1255586C>T	ExAC,gnomAD
rs916497220	p.Pro341Arg	missense variant	-	NC_000019.10:g.1255587C>G	TOPMed,gnomAD
rs775164553	p.Ala342Val	missense variant	-	NC_000019.10:g.1255590C>T	ExAC,gnomAD
rs1286561055	p.Pro343Arg	missense variant	-	NC_000019.10:g.1255593C>G	gnomAD
rs760387260	p.Pro343Ser	missense variant	-	NC_000019.10:g.1255592C>T	ExAC,gnomAD
rs537901815	p.Asp344Asn	missense variant	-	NC_000019.10:g.1255595G>A	ExAC,gnomAD
rs572411883	p.Ala346Ser	missense variant	-	NC_000019.10:g.1255601G>T	ExAC,gnomAD
rs572411883	p.Ala346Thr	missense variant	-	NC_000019.10:g.1255601G>A	ExAC,gnomAD
rs187496777	p.Pro347Thr	missense variant	-	NC_000019.10:g.1255604C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1453278520	p.Pro347Leu	missense variant	-	NC_000019.10:g.1255605C>T	TOPMed
rs187496777	p.Pro347Ser	missense variant	-	NC_000019.10:g.1255604C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs750505892	p.Thr350Asn	missense variant	-	NC_000019.10:g.1255614C>A	ExAC,TOPMed,gnomAD
rs750505892	p.Thr350Ile	missense variant	-	NC_000019.10:g.1255614C>T	ExAC,TOPMed,gnomAD
rs948365922	p.Cys352Phe	missense variant	-	NC_000019.10:g.1255620G>T	TOPMed,gnomAD
rs1360385206	p.Cys352Arg	missense variant	-	NC_000019.10:g.1255619T>C	gnomAD
rs768320010	p.Glu353Lys	missense variant	-	NC_000019.10:g.1255622G>A	ExAC,TOPMed,gnomAD
rs781621709	p.Glu353Val	missense variant	-	NC_000019.10:g.1255623A>T	ExAC,gnomAD
rs1313914947	p.Lys354Met	missense variant	-	NC_000019.10:g.1255626A>T	TOPMed,gnomAD
rs1313914947	p.Lys354Thr	missense variant	-	NC_000019.10:g.1255626A>C	TOPMed,gnomAD
rs1241608054	p.Leu355Val	missense variant	-	NC_000019.10:g.1255628C>G	gnomAD
rs375858262	p.Thr356Ala	missense variant	-	NC_000019.10:g.1255631A>G	ESP,ExAC,TOPMed,gnomAD
rs375858262	p.Thr356Ser	missense variant	-	NC_000019.10:g.1255631A>T	ESP,ExAC,TOPMed,gnomAD
rs142253784	p.Thr356Met	missense variant	-	NC_000019.10:g.1255632C>T	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala357Ser	missense variant	-	NC_000019.10:g.1255634G>T	NCI-TCGA
rs746690125	p.Ala358Val	missense variant	-	NC_000019.10:g.1255638C>T	ExAC,TOPMed,gnomAD
rs866456084	p.Ala358Thr	missense variant	-	NC_000019.10:g.1255637G>A	gnomAD
rs776504138	p.Pro359Leu	missense variant	-	NC_000019.10:g.1255641C>T	ExAC,gnomAD
rs373393011	p.Pro359Ser	missense variant	-	NC_000019.10:g.1255640C>T	ESP,TOPMed,gnomAD
NCI-TCGA novel	p.Ser360GlnPheSerTerUnkUnkUnk	frameshift	-	NC_000019.10:g.1255638C>-	NCI-TCGA
rs769818681	p.Ala361Gly	missense variant	-	NC_000019.10:g.1255647C>G	ExAC,TOPMed,gnomAD
rs769818681	p.Ala361Val	missense variant	-	NC_000019.10:g.1255647C>T	ExAC,TOPMed,gnomAD
rs1465794325	p.Gly366Ser	missense variant	-	NC_000019.10:g.1255661G>A	gnomAD
rs1405019786	p.Gly366Asp	missense variant	-	NC_000019.10:g.1255662G>A	TOPMed
rs1164743688	p.Arg371Cys	missense variant	-	NC_000019.10:g.1255676C>T	TOPMed,gnomAD
rs753084988	p.Pro375Ser	missense variant	-	NC_000019.10:g.1255688C>T	ExAC,gnomAD
rs1028967377	p.Pro375His	missense variant	-	NC_000019.10:g.1255689C>A	TOPMed
rs539386845	p.Pro376Ser	missense variant	-	NC_000019.10:g.1255691C>T	1000Genomes,ExAC,gnomAD
rs377416779	p.Pro376Leu	missense variant	-	NC_000019.10:g.1255692C>T	ESP,ExAC,TOPMed,gnomAD
rs1301207246	p.Gly377Val	missense variant	-	NC_000019.10:g.1256995G>T	gnomAD
rs770879927	p.Asp378Val	missense variant	-	NC_000019.10:g.1256998A>T	ExAC,gnomAD
rs9823	p.Asp378Glu	missense variant	-	NC_000019.10:g.1256999C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs139717027	p.Arg379Trp	missense variant	-	NC_000019.10:g.1257000C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs775635166	p.Arg379Gln	missense variant	-	NC_000019.10:g.1257001G>A	ExAC,gnomAD
rs760894675	p.Arg381Trp	missense variant	-	NC_000019.10:g.1257006C>T	ExAC,TOPMed,gnomAD
rs376980746	p.Arg381Gln	missense variant	-	NC_000019.10:g.1257007G>A	ESP,ExAC,TOPMed,gnomAD
rs1358802007	p.Gln382His	missense variant	-	NC_000019.10:g.1257011G>C	TOPMed,gnomAD
rs1220987146	p.Asn385Asp	missense variant	-	NC_000019.10:g.1257018A>G	TOPMed,gnomAD
rs777006467	p.Arg386Gly	missense variant	-	NC_000019.10:g.1257021C>G	ExAC,TOPMed,gnomAD
rs1488829360	p.Arg386His	missense variant	-	NC_000019.10:g.1257022G>A	gnomAD
rs777006467	p.Arg386Cys	missense variant	-	NC_000019.10:g.1257021C>T	ExAC,TOPMed,gnomAD
rs561185140	p.Ala387Thr	missense variant	-	NC_000019.10:g.1257024G>A	1000Genomes,ExAC,gnomAD
rs149895689	p.Thr388Met	missense variant	-	NC_000019.10:g.1257028C>T	ESP,ExAC,TOPMed,gnomAD
rs1423452435	p.Arg389His	missense variant	-	NC_000019.10:g.1257031G>A	gnomAD
rs766939917	p.Arg389Cys	missense variant	-	NC_000019.10:g.1257030C>T	ExAC,TOPMed,gnomAD
rs890143559	p.Cys390Arg	missense variant	-	NC_000019.10:g.1257033T>C	TOPMed,gnomAD
rs890143559	p.Cys390Gly	missense variant	-	NC_000019.10:g.1257033T>G	TOPMed,gnomAD
NCI-TCGA novel	p.Lys391Arg	missense variant	-	NC_000019.10:g.1257037A>G	NCI-TCGA
rs1281382030	p.Glu393Gln	missense variant	-	NC_000019.10:g.1257042G>C	TOPMed
rs1317423292	p.Arg394Gln	missense variant	-	NC_000019.10:g.1257046G>A	gnomAD
rs1438859755	p.Arg394Trp	missense variant	-	NC_000019.10:g.1257045C>T	TOPMed
rs1326903964	p.Gln396Leu	missense variant	-	NC_000019.10:g.1257052A>T	TOPMed
rs1443565627	p.Leu398Val	missense variant	-	NC_000019.10:g.1257057C>G	TOPMed
rs777616787	p.Gln400Arg	missense variant	-	NC_000019.10:g.1257064A>G	ExAC,gnomAD
rs753656348	p.Gln401His	missense variant	-	NC_000019.10:g.1257068G>C	ExAC,gnomAD
rs905382315	p.Arg403Trp	missense variant	-	NC_000019.10:g.1257072C>T	TOPMed
rs371624768	p.Arg403Gln	missense variant	-	NC_000019.10:g.1257073G>A	ESP,ExAC,TOPMed,gnomAD
rs778898762	p.Arg405Ser	missense variant	-	NC_000019.10:g.1257078C>A	ExAC,gnomAD
rs778898762	p.Arg405Cys	missense variant	-	NC_000019.10:g.1257078C>T	ExAC,gnomAD
rs772126592	p.Arg405His	missense variant	-	NC_000019.10:g.1257079G>A	ExAC,gnomAD
rs772126592	p.Arg405Leu	missense variant	-	NC_000019.10:g.1257079G>T	ExAC,gnomAD
rs1211888524	p.Arg406Gly	missense variant	-	NC_000019.10:g.1257081A>G	TOPMed,gnomAD
rs780142860	p.Lys407Arg	missense variant	-	NC_000019.10:g.1257085A>G	ExAC,gnomAD
rs1035267831	p.Arg410Gln	missense variant	-	NC_000019.10:g.1257094G>A	TOPMed,gnomAD
rs762221657	p.Asp411Glu	missense variant	-	NC_000019.10:g.1257098C>G	ExAC,TOPMed,gnomAD
rs776900685	p.Asp411Gly	missense variant	-	NC_000019.10:g.1257097A>G	ExAC,TOPMed,gnomAD
rs1448188445	p.Asp411His	missense variant	-	NC_000019.10:g.1257096G>C	gnomAD
rs773701369	p.Ala412Thr	missense variant	-	NC_000019.10:g.1257099G>A	ExAC,gnomAD
rs763398874	p.Ala412Val	missense variant	-	NC_000019.10:g.1257100C>T	ExAC,TOPMed,gnomAD
rs760302974	p.Arg413Gln	missense variant	-	NC_000019.10:g.1257103G>A	ExAC,TOPMed,gnomAD
rs763834960	p.Gly414Cys	missense variant	-	NC_000019.10:g.1257105G>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gly414Arg	missense variant	-	NC_000019.10:g.1257105G>C	NCI-TCGA
rs1333492951	p.Pro415Leu	missense variant	-	NC_000019.10:g.1257109C>T	gnomAD
COSM225397	p.Pro415Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000019.10:g.1257108C>T	NCI-TCGA Cosmic
rs757020602	p.Tyr416Ter	stop gained	-	NC_000019.10:g.1257113C>A	ExAC,gnomAD
COSM4074359	p.Tyr416Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000019.10:g.1257112A>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.His417Gln	missense variant	-	NC_000019.10:g.1257116C>A	NCI-TCGA
rs764949586	p.Ser419Pro	missense variant	-	NC_000019.10:g.1257120T>C	ExAC,TOPMed,gnomAD
rs1347434139	p.Pro420Ala	missense variant	-	NC_000019.10:g.1257123C>G	TOPMed,gnomAD
rs148644773	p.Arg422Leu	missense variant	-	NC_000019.10:g.1257130G>T	ESP,ExAC,TOPMed,gnomAD
rs143942530	p.Arg422Cys	missense variant	-	NC_000019.10:g.1257129C>T	ESP,ExAC,TOPMed,gnomAD
rs148644773	p.Arg422His	missense variant	-	NC_000019.10:g.1257130G>A	ESP,ExAC,TOPMed,gnomAD
rs1460625227	p.Ala424Pro	missense variant	-	NC_000019.10:g.1257135G>C	gnomAD
rs147781717	p.Gly425Arg	missense variant	-	NC_000019.10:g.1257138G>C	ESP,ExAC,TOPMed,gnomAD
rs147781717	p.Gly425Ser	missense variant	-	NC_000019.10:g.1257138G>A	ESP,ExAC,TOPMed,gnomAD
COSM3403772	p.Gly425Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000019.10:g.1257139G>A	NCI-TCGA Cosmic
rs773469970	p.Arg426His	missense variant	-	NC_000019.10:g.1257142G>A	ExAC,TOPMed,gnomAD
rs770154213	p.Arg426Cys	missense variant	-	NC_000019.10:g.1257141C>T	ExAC,TOPMed,gnomAD
rs773469970	p.Arg426Leu	missense variant	-	NC_000019.10:g.1257142G>T	ExAC,TOPMed,gnomAD
rs773469970	p.Arg426Pro	missense variant	-	NC_000019.10:g.1257142G>C	ExAC,TOPMed,gnomAD
rs1418401940	p.Asp428Glu	missense variant	-	NC_000019.10:g.1257149C>G	TOPMed
rs539586624	p.Asp428Asn	missense variant	-	NC_000019.10:g.1257147G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs61743656	p.Ser429Asn	missense variant	-	NC_000019.10:g.1257151G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1186868811	p.Ser429Gly	missense variant	-	NC_000019.10:g.1257150A>G	TOPMed
rs61743656	p.Ser429Thr	missense variant	-	NC_000019.10:g.1257151G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1186868811	p.Ser429Cys	missense variant	-	NC_000019.10:g.1257150A>T	TOPMed
COSM3748042	p.Ser430Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000019.10:g.1257155T>G	NCI-TCGA Cosmic
rs761405102	p.Gly433Arg	missense variant	-	NC_000019.10:g.1257162G>A	ExAC,gnomAD
COSM1390518	p.Gly434AlaPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	NC_000019.10:g.1257162G>-	NCI-TCGA Cosmic
rs890720169	p.Gly435Val	missense variant	-	NC_000019.10:g.1257169G>T	gnomAD
rs570181170	p.Gly435Arg	missense variant	-	NC_000019.10:g.1257168G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs570181170	p.Gly435Ser	missense variant	-	NC_000019.10:g.1257168G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs537671815	p.Gly436Ser	missense variant	-	NC_000019.10:g.1257171G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs147606566	p.Gly436Val	missense variant	-	NC_000019.10:g.1257172G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs147606566	p.Gly436Asp	missense variant	-	NC_000019.10:g.1257172G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs781280500	p.Ser437Gly	missense variant	-	NC_000019.10:g.1257174A>G	ExAC,TOPMed,gnomAD
rs372267981	p.Ser439Asn	missense variant	-	NC_000019.10:g.1257181G>A	ESP,ExAC,TOPMed,gnomAD
rs372267981	p.Ser439Ile	missense variant	-	NC_000019.10:g.1257181G>T	ESP,ExAC,TOPMed,gnomAD
rs201498147	p.Ser439Arg	missense variant	-	NC_000019.10:g.1257182C>G	ESP,ExAC,TOPMed,gnomAD
rs372267981	p.Ser439Thr	missense variant	-	NC_000019.10:g.1257181G>C	ESP,ExAC,TOPMed,gnomAD
rs955924688	p.Glu440Lys	missense variant	-	NC_000019.10:g.1257183G>A	TOPMed,gnomAD
NCI-TCGA novel	p.Glu440Gln	missense variant	-	NC_000019.10:g.1257183G>C	NCI-TCGA
rs771481143	p.Gly443Ser	missense variant	-	NC_000019.10:g.1257192G>A	ExAC,gnomAD
rs1332846558	p.Leu444Ser	missense variant	-	NC_000019.10:g.1257196T>C	gnomAD
rs746383092	p.Gly445Ser	missense variant	-	NC_000019.10:g.1257198G>A	ExAC,gnomAD
rs201428769	p.Leu446Arg	missense variant	-	NC_000019.10:g.1257202T>G	1000Genomes,ExAC,TOPMed,gnomAD
rs768243814	p.Leu446Ile	missense variant	-	NC_000019.10:g.1257201C>A	ExAC,TOPMed,gnomAD
rs764769740	p.Asp447Asn	missense variant	-	NC_000019.10:g.1257204G>A	ExAC,gnomAD
rs1190136040	p.Glu449Lys	missense variant	-	NC_000019.10:g.1257210G>A	TOPMed
rs1344096619	p.Val452Leu	missense variant	-	NC_000019.10:g.1257219G>T	gnomAD
rs1344096619	p.Val452Met	missense variant	-	NC_000019.10:g.1257219G>A	gnomAD
rs1402228240	p.Trp453Gly	missense variant	-	NC_000019.10:g.1257222T>G	gnomAD
rs1326621390	p.Glu456Asp	missense variant	-	NC_000019.10:g.1257233A>T	gnomAD
rs1226189478	p.Pro459Thr	missense variant	-	NC_000019.10:g.1257240C>A	gnomAD
NCI-TCGA novel	p.Glu464ArgPheSerTerUnkUnk	frameshift	-	NC_000019.10:g.1257253_1257254insA	NCI-TCGA
rs752687659	p.Val466Met	missense variant	-	NC_000019.10:g.1257261G>A	ExAC,gnomAD
rs756283647	p.Val466Ala	missense variant	-	NC_000019.10:g.1257262T>C	ExAC,gnomAD
rs200865184	p.Ala468Thr	missense variant	-	NC_000019.10:g.1257267G>A	1000Genomes,ExAC,gnomAD

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0003674	molecular_function	ND
GO:0019900	kinase binding	ISS

GO:Biological Process

GO ID	GO Term	Evidence
GO:0008150	biological_process	ND
GO:0033132	negative regulation of glucokinase activity	ISS
GO:0046676	negative regulation of insulin secretion	ISS

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005634	nucleus	IBA
GO:0005634	nucleus	IDA
GO:0005730	nucleolus	IEA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	IEA

Reactome Pathway

Reactome ID	Reactome Term	Evidence

Drugs and compounds information

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MIDN mRNA	19114083
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MIDN mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MIDN mRNA	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of MIDN mRNA	19561079
D000082	Acetaminophen	Acetaminophen results in increased expression of MIDN mRNA	21420995; 29067470;
D000082	Acetaminophen	Acetaminophen affects the expression of MIDN mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MIDN mRNA	22100608
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of MIDN mRNA	24449571
D001104	Arbutin	Arbutin results in decreased expression of MIDN mRNA	17103032
D001151	Arsenic	Arsenic results in decreased expression of MIDN mRNA	27838757
D001507	Beclomethasone	Beclomethasone results in increased expression of MIDN mRNA	23656298
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to MIDN promoter]	19654925
C044887	beta-methylcholine	beta-methylcholine affects the expression of MIDN mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of MIDN mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of MIDN mRNA	25047013
C006780	bisphenol A	bisphenol A affects the expression of MIDN mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of MIDN mRNA	30816183
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of MIDN mRNA	23650126
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of MIDN mRNA	21356183
D002945	Cisplatin	Cisplatin results in decreased expression of MIDN mRNA	27594783
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of MIDN mRNA	24690739
D019327	Copper Sulfate	Copper Sulfate results in increased expression of MIDN mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of MIDN mRNA	25562108
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of MIDN mRNA	24317228
C000944	dicrotophos	dicrotophos results in increased expression of MIDN mRNA	28302478
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of MIDN mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of MIDN mRNA]	19850644
D004147	Dioxins	Dioxins affects the expression of MIDN mRNA	20463971
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of MIDN mRNA	24690739
C012301	domoic acid	domoic acid results in increased expression of MIDN mRNA	18936300
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MIDN mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MIDN mRNA	27188386
D004317	Doxorubicin	Doxorubicin results in decreased expression of MIDN mRNA	29803840
D000431	Ethanol	Ethanol results in increased expression of MIDN mRNA	29361514
D000431	Ethanol	Ethanol affects the expression of and affects the splicing of MIDN mRNA	30319688
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of MIDN mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MIDN mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MIDN mRNA	17942748
D017313	Fenretinide	Fenretinide results in increased expression of MIDN mRNA	28973697
D005897	Glafenine	Glafenine results in increased expression of MIDN mRNA	24136188
C514793	gp120 protein, Human immunodeficiency virus 1	[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of MIDN mRNA	18606552
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MIDN mRNA	23086925
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of MIDN mRNA	24796395; 27432991;
C410337	K 7174	K 7174 results in increased expression of MIDN mRNA	24086573
D048628	Ketolides	Ketolides analog results in decreased expression of MIDN mRNA	24967691
C011890	kojic acid	kojic acid results in decreased expression of MIDN mRNA	16595896
D016912	Levonorgestrel	[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of MIDN mRNA	19074003
C482199	lipopolysaccharide, E coli O55-B5	lipopolysaccharide, E coli O55-B5 results in decreased expression of MIDN mRNA	24972896
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MIDN mRNA	23179753
C059539	midostaurin	midostaurin results in increased expression of MIDN mRNA	20980353
C568376	MT19c compound	MT19c compound results in decreased expression of MIDN mRNA	21781307
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of MIDN mRNA	29244179
D009966	Orphenadrine	Orphenadrine affects the expression of MIDN mRNA	23665939
C006253	pirinixic acid	pirinixic acid results in increased expression of MIDN mRNA	18445702
C045950	propiconazole	propiconazole results in decreased expression of MIDN mRNA	21278054
D011794	Quercetin	Quercetin results in increased expression of MIDN mRNA	21632981
D012402	Rotenone	Rotenone results in increased expression of MIDN mRNA	28374803
D013629	Tamoxifen	Tamoxifen affects the expression of MIDN mRNA	17555576
C010792	testosterone undecanoate	[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of MIDN mRNA	19074003
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MIDN mRNA	21570461; 24680724;
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MIDN mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MIDN mRNA	26290441
D013749	Tetrachlorodibenzodioxin	[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of MIDN mRNA	25975270
D013853	Thioacetamide	Thioacetamide results in increased expression of MIDN mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MIDN mRNA	28065790
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MIDN mRNA	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of MIDN mRNA	26272509
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MIDN mRNA	26743178
D014414	Tungsten	Tungsten results in decreased expression of MIDN mRNA	30912803
D014415	Tunicamycin	Tunicamycin results in decreased expression of MIDN mRNA	29453283
D014520	Urethane	Urethane results in increased expression of MIDN mRNA	28818685
C406224	valdecoxib	valdecoxib results in increased expression of MIDN mRNA	24136188
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MIDN mRNA	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MIDN mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of MIDN mRNA	23179753; 26272509; 27188386; 29154799;
D014635	Valproic Acid	Valproic Acid results in increased methylation of MIDN gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of MIDN gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of MIDN mRNA	23034163
D000077337	Vorinostat	Vorinostat results in decreased expression of MIDN mRNA	27188386
D016047	Zalcitabine	[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of MIDN mRNA	18606552

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0963	Cytoplasm
KW-0539	Nucleus
KW-1185	Reference proteome

Interpro

InterPro ID	InterPro Term
IPR039336	Midnolin
IPR000626	Ubiquitin-like_dom
IPR029071	Ubiquitin-like_domsf

PROSITE

PROSITE ID	PROSITE Term
PS50053	UBIQUITIN_2

Pfam

Pfam ID	Pfam Term
PF00240	ubiquitin

Gene: MIDN

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Other genetic variants/mutations

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction