CleftGeneDB-Search

Gene: WLS

Basic information

Tag	Content
Uniprot ID	Q5T9L3; B2RNT2; Q5JRS7; Q7Z2Z9; Q8NC43;
Entrez ID	79971
Genbank protein ID	BAC11333.1; AAQ89394.1; AAI37114.1; EAX06481.1; AAI37110.1; EAX06480.1; CAD98094.1; ABD58927.1; AAI10827.1;
Genbank nucleotide ID	NM_001193334.1; NM_024911.6; NM_001002292.3;
Ensembl protein ID	ENSP00000346829; ENSP00000360015; ENSP00000262348;
Ensembl nucleotide ID	ENSG00000116729
Gene name	Protein wntless homolog
Gene symbol	WLS
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
Sequence	MAGAIIENMS TKKLCIVGGI LLVFQIIAFL VGGLIAPGPT TAVSYMSVKC VDARKNHHKT 60 KWFVPWGPNH CDKIRDIEEA IPREIEANDI VFSVHIPLPH MEMSPWFQFM LFILQLDIAF 120 KLNNQIRENA EVSMDVSLAY RDDAFAEWTE MAHERVPRKL KCTFTSPKTP EHEGRYYECD 180 VLPFMEIGSV AHKFYLLNIR LPVNEKKKIN VGIGEIKDIR LVGIHQNGGF TKVWFAMKTF 240 LTPSIFIIMV WYWRRITMMS RPPVLLEKVI FALGISMTFI NIPVEWFSIG FDWTWMLLFG 300 DIRQGIFYAM LLSFWIIFCG EHMMDQHERN HIAGYWKQVG PIAVGSFCLF IFDMCERGVQ 360 LTNPFYSIWT TDIGTELAMA FIIVAGICLC LYFLFLCFMV FQVFRNISGK QSSLPAMSKV 420 RRLHYEGLIF RFKFLMLITL ACAAMTVIFF IVSQVTEGHW KWGGVTVQVN SAFFTGIYGM 480 WNLYVFALMF LYAPSHKNYG EDQSNGDLGV HSGEELQLTT TITHVDGPTE IYKLTRKEAQ 540 E 541

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	WLS	528123	E1BDN1			Bos taurus	Prediction	More>>
1:1 ortholog	WLS	611491	E2QUQ5			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	WLS	102174896	A0A452ES79			Capra hircus	Prediction	More>>
1:1 ortholog	WLS	100053710	A0A3Q2HI43			Equus caballus	Prediction	More>>
1:1 ortholog	WLS	79971	Q5T9L3			Homo sapiens	Prediction	More>>
1:1 ortholog	Wls	68151	Q6DID7	CPO	E11.5, E12.5, E13.5, E14.5, E15.5, E18.5	Mus musculus	Publication	More>>
1:1 ortholog	WLS	456931	K7C6F2			Pan troglodytes	Prediction	More>>
1:1 ortholog	WLS		A0A287A5R0			Sus scrofa	Prediction	More>>
1:1 ortholog	WLS	100352518	G1SDH8			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Wls	362065	Q6P689			Rattus norvegicus	Prediction	More>>
1:1 ortholog	wls	406420	F2Z4U3			Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs148747626	p.Ala2Val	missense variant	-	NC_000001.11:g.68232295G>A	ESP
rs1160503998	p.Ile5Val	missense variant	-	NC_000001.11:g.68232287T>C	TOPMed
rs991607842	p.Ile6Met	missense variant	-	NC_000001.11:g.68232282T>C	TOPMed
rs1385830152	p.Ile6Thr	missense variant	-	NC_000001.11:g.68232283A>G	TOPMed
rs746323384	p.Met9Val	missense variant	-	NC_000001.11:g.68232275T>C	ExAC,gnomAD
rs746323384	p.Met9Leu	missense variant	-	NC_000001.11:g.68232275T>G	ExAC,gnomAD
rs1312050404	p.Thr11Ser	missense variant	-	NC_000001.11:g.68232268G>C	gnomAD
rs1412473355	p.Cys15Gly	missense variant	-	NC_000001.11:g.68232257A>C	gnomAD
COSM911883	p.Ile16Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68232253A>G	NCI-TCGA Cosmic
rs781704177	p.Ile16Asn	missense variant	-	NC_000001.11:g.68232253A>T	ExAC,TOPMed,gnomAD
rs781704177	p.Ile16Ser	missense variant	-	NC_000001.11:g.68232253A>C	ExAC,TOPMed,gnomAD
rs1376915170	p.Ile16Leu	missense variant	-	NC_000001.11:g.68232254T>G	gnomAD
rs1405226335	p.Gly18Asp	missense variant	-	NC_000001.11:g.68232247C>T	gnomAD
rs1157324101	p.Gly19Val	missense variant	-	NC_000001.11:g.68232244C>A	gnomAD
COSM1296665	p.Leu22His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68232235A>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Val23Met	missense variant	-	NC_000001.11:g.68232233C>T	NCI-TCGA
rs752417486	p.Gln25His	missense variant	-	NC_000001.11:g.68232225T>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gln25SerPheSerTerUnk	frameshift	-	NC_000001.11:g.68232224_68232227TTTG>-	NCI-TCGA
COSM911879	p.Ile26Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68232224T>A	NCI-TCGA Cosmic
rs764608845	p.Ile26Val	missense variant	-	NC_000001.11:g.68232224T>C	ExAC,gnomAD
rs571754253	p.Ile27Val	missense variant	-	NC_000001.11:g.68232221T>C	TOPMed,gnomAD
rs1446481673	p.Ala28Val	missense variant	-	NC_000001.11:g.68232217G>A	gnomAD
rs1342479853	p.Val31Ala	missense variant	-	NC_000001.11:g.68232208A>G	TOPMed,gnomAD
rs754478658	p.Gly32Arg	missense variant	-	NC_000001.11:g.68232206C>T	ExAC,gnomAD
rs753335690	p.Gly33Ala	missense variant	-	NC_000001.11:g.68232202C>G	ExAC,gnomAD
rs142958013	p.Leu34Phe	missense variant	-	NC_000001.11:g.68232198C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs760671910	p.Ile35Thr	missense variant	-	NC_000001.11:g.68232196A>G	ExAC,gnomAD
rs906535549	p.Pro37Ala	missense variant	-	NC_000001.11:g.68194225G>C	TOPMed
rs1270543034	p.Thr40Ala	missense variant	-	NC_000001.11:g.68194216T>C	TOPMed,gnomAD
rs757203223	p.Thr41Met	missense variant	-	NC_000001.11:g.68194212G>A	ExAC,TOPMed,gnomAD
rs763804728	p.Ala42Val	missense variant	-	NC_000001.11:g.68194209G>A	ExAC,TOPMed,gnomAD
rs763804728	p.Ala42Gly	missense variant	-	NC_000001.11:g.68194209G>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala42Thr	missense variant	-	NC_000001.11:g.68194210C>T	NCI-TCGA
rs1247182493	p.Val43Ala	missense variant	-	NC_000001.11:g.68194206A>G	gnomAD
rs149439243	p.Ser44Phe	missense variant	-	NC_000001.11:g.68194203G>A	ESP,gnomAD
rs754140558	p.Tyr45Cys	missense variant	-	NC_000001.11:g.68194200T>C	ExAC,gnomAD
rs754140558	p.Tyr45Ser	missense variant	-	NC_000001.11:g.68194200T>G	ExAC,gnomAD
rs368633951	p.Met46Val	missense variant	-	NC_000001.11:g.68194198T>C	ExAC,TOPMed,gnomAD
rs368633951	p.Met46Leu	missense variant	-	NC_000001.11:g.68194198T>A	ExAC,TOPMed,gnomAD
rs544767216	p.Ser47Leu	missense variant	-	NC_000001.11:g.68194194G>A	1000Genomes,ExAC,gnomAD
rs774719446	p.Val48Glu	missense variant	-	NC_000001.11:g.68194191A>T	ExAC,TOPMed,gnomAD
rs1164793591	p.Lys49Arg	missense variant	-	NC_000001.11:g.68194188T>C	gnomAD
rs768925172	p.Val51Met	missense variant	-	NC_000001.11:g.68194183C>T	ExAC,gnomAD
rs1328210658	p.Val51Ala	missense variant	-	NC_000001.11:g.68194182A>G	TOPMed
COSM1344081	p.Ala53Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68194176G>A	NCI-TCGA Cosmic
rs368075278	p.Arg54Cys	missense variant	-	NC_000001.11:g.68194174G>A	ESP,ExAC,TOPMed,gnomAD
rs553607184	p.Arg54Pro	missense variant	-	NC_000001.11:g.68194173C>G	ExAC,TOPMed,gnomAD
rs368075278	p.Arg54Gly	missense variant	-	NC_000001.11:g.68194174G>C	ESP,ExAC,TOPMed,gnomAD
rs553607184	p.Arg54His	missense variant	-	NC_000001.11:g.68194173C>T	ExAC,TOPMed,gnomAD
rs553607184	p.Arg54Leu	missense variant	-	NC_000001.11:g.68194173C>A	ExAC,TOPMed,gnomAD
rs1468434317	p.del55TyrPheTyrTerAsnTrpLeuLys	stop gained	-	NC_000001.11:g.68194171_68194172insTTTGAGCCAATTCTAATAAAAGTA	gnomAD
rs751470492	p.His58Pro	missense variant	-	NC_000001.11:g.68194161T>G	ExAC,TOPMed,gnomAD
rs751470492	p.His58Arg	missense variant	-	NC_000001.11:g.68194161T>C	ExAC,TOPMed,gnomAD
COSM911875	p.Lys59Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68194157C>A	NCI-TCGA Cosmic
rs777581379	p.Lys59Arg	missense variant	-	NC_000001.11:g.68194158T>C	ExAC,gnomAD
rs1324814155	p.Thr60Lys	missense variant	-	NC_000001.11:g.68194155G>T	gnomAD
rs138728794	p.Phe63Leu	missense variant	-	NC_000001.11:g.68194147A>G	ESP,ExAC,TOPMed,gnomAD
rs766692927	p.Val64Met	missense variant	-	NC_000001.11:g.68194144C>T	ExAC,TOPMed,gnomAD
rs1368725790	p.Pro65Ser	missense variant	-	NC_000001.11:g.68194141G>A	gnomAD
rs1387104299	p.Gly67Glu	missense variant	-	NC_000001.11:g.68194134C>T	gnomAD
rs1325236247	p.Gly67Arg	missense variant	-	NC_000001.11:g.68194135C>T	gnomAD
NCI-TCGA novel	p.Lys73Glu	missense variant	-	NC_000001.11:g.68194117T>C	NCI-TCGA
rs762333679	p.Arg75Gln	missense variant	-	NC_000001.11:g.68194110C>T	ExAC,TOPMed,gnomAD
rs1431322012	p.Arg75Ter	stop gained	-	NC_000001.11:g.68194111G>A	gnomAD
rs762333679	p.Arg75Pro	missense variant	-	NC_000001.11:g.68194110C>G	ExAC,TOPMed,gnomAD
rs150131585	p.Asp76Gly	missense variant	-	NC_000001.11:g.68194107T>C	1000Genomes,ExAC,TOPMed,gnomAD
rs954098988	p.Asp76Asn	missense variant	-	NC_000001.11:g.68194108C>T	TOPMed
rs763208016	p.Glu78Lys	missense variant	-	NC_000001.11:g.68194102C>T	ExAC,gnomAD
rs775892939	p.Glu79Val	missense variant	-	NC_000001.11:g.68194098T>A	ExAC,gnomAD
rs1452534553	p.Ala80Val	missense variant	-	NC_000001.11:g.68194095G>A	gnomAD
rs1250332149	p.Pro82Ser	missense variant	-	NC_000001.11:g.68194090G>A	gnomAD
rs769435154	p.Pro82Leu	missense variant	-	NC_000001.11:g.68194089G>A	ExAC,TOPMed,gnomAD
rs1290296126	p.Arg83Thr	missense variant	-	NC_000001.11:g.68194086C>G	gnomAD
rs541503463	p.Ile85Thr	missense variant	-	NC_000001.11:g.68194080A>G	1000Genomes,ExAC,gnomAD
rs770374634	p.Asn88His	missense variant	-	NC_000001.11:g.68194072T>G	ExAC,gnomAD
rs1345869035	p.Asn88Ser	missense variant	-	NC_000001.11:g.68194071T>C	gnomAD
rs777546417	p.Asp89Asn	missense variant	-	NC_000001.11:g.68194069C>T	ExAC,TOPMed,gnomAD
rs3748704	p.Asp89Gly	missense variant	-	NC_000001.11:g.68194068T>C	1000Genomes,ExAC,TOPMed,gnomAD
rs747950708	p.Ile90Met	missense variant	-	NC_000001.11:g.68194064G>C	ExAC,TOPMed,gnomAD
rs1032223810	p.Ile90Asn	missense variant	-	NC_000001.11:g.68194065A>T	gnomAD
rs778854489	p.Val91Met	missense variant	-	NC_000001.11:g.68194063C>T	ExAC,gnomAD
COSM4009689	p.Phe92Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68194060A>C	NCI-TCGA Cosmic
rs756346412	p.Ser93Pro	missense variant	-	NC_000001.11:g.68194057A>G	ExAC,gnomAD
rs1254235090	p.Pro97His	missense variant	-	NC_000001.11:g.68194044G>T	TOPMed
rs767595399	p.Pro99Arg	missense variant	-	NC_000001.11:g.68194038G>C	ExAC,gnomAD
rs143496382	p.His100Asn	missense variant	-	NC_000001.11:g.68194036G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs143496382	p.His100Tyr	missense variant	-	NC_000001.11:g.68194036G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs143496382	p.His100Asp	missense variant	-	NC_000001.11:g.68194036G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.His100Gln	missense variant	-	NC_000001.11:g.68194034G>C	NCI-TCGA
rs763521771	p.Met101Thr	missense variant	-	NC_000001.11:g.68194032A>G	ExAC,gnomAD
rs145598961	p.Met101Val	missense variant	-	NC_000001.11:g.68194033T>C	ESP,TOPMed
rs1414608786	p.Pro105Thr	missense variant	-	NC_000001.11:g.68194021G>T	TOPMed
rs775768174	p.Trp106Ser	missense variant	-	NC_000001.11:g.68194017C>G	ExAC,TOPMed,gnomAD
rs570724708	p.Gln108Arg	missense variant	-	NC_000001.11:g.68194011T>C	1000Genomes,ExAC,gnomAD
rs770663060	p.Met110Ile	missense variant	-	NC_000001.11:g.68194004C>T	ExAC,TOPMed,gnomAD
rs770663060	p.Met110Ile	missense variant	-	NC_000001.11:g.68194004C>G	ExAC,TOPMed,gnomAD
rs1280908953	p.Leu111Val	missense variant	-	NC_000001.11:g.68194003G>C	gnomAD
NCI-TCGA novel	p.Leu111Pro	missense variant	-	NC_000001.11:g.68194002A>G	NCI-TCGA
NCI-TCGA novel	p.Gln115Lys	missense variant	-	NC_000001.11:g.68193991G>T	NCI-TCGA
rs772843643	p.Asp117Asn	missense variant	-	NC_000001.11:g.68193985C>T	ExAC,gnomAD
rs772843643	p.Asp117His	missense variant	-	NC_000001.11:g.68193985C>G	ExAC,gnomAD
rs371055975	p.Ile118Val	missense variant	-	NC_000001.11:g.68193982T>C	TOPMed
rs1230040980	p.Phe120Val	missense variant	-	NC_000001.11:g.68193976A>C	gnomAD
rs1350930037	p.Gln125Arg	missense variant	-	NC_000001.11:g.68193960T>C	gnomAD
COSM3805852	p.Glu128Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68159245C>G	NCI-TCGA Cosmic
rs756461463	p.Asn129Lys	missense variant	-	NC_000001.11:g.68159240A>C	ExAC,TOPMed,gnomAD
rs1397817828	p.Asn129Asp	missense variant	-	NC_000001.11:g.68159242T>C	TOPMed,gnomAD
rs750775053	p.Ala130Val	missense variant	-	NC_000001.11:g.68159238G>A	ExAC,TOPMed,gnomAD
rs1362043951	p.Val132Leu	missense variant	-	NC_000001.11:g.68159233C>G	TOPMed
rs1032499675	p.Ser133Thr	missense variant	-	NC_000001.11:g.68159230A>T	TOPMed
rs1455578958	p.Met134Thr	missense variant	-	NC_000001.11:g.68159226A>G	gnomAD
rs767220868	p.Asp135Asn	missense variant	-	NC_000001.11:g.68159224C>T	ExAC,gnomAD
rs1159698998	p.Asp135Glu	missense variant	-	NC_000001.11:g.68159222G>T	gnomAD
rs368487427	p.Val136Ile	missense variant	-	NC_000001.11:g.68159221C>T	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Val136Leu	missense variant	-	NC_000001.11:g.68159221C>G	NCI-TCGA
rs1446299201	p.Ala139Val	missense variant	-	NC_000001.11:g.68159211G>A	TOPMed
rs751107411	p.Tyr140Cys	missense variant	-	NC_000001.11:g.68159208T>C	ExAC,TOPMed,gnomAD
COSM426638	p.Arg141His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68159205C>T	NCI-TCGA Cosmic
rs1384225388	p.Asp143Val	missense variant	-	NC_000001.11:g.68159199T>A	TOPMed
rs146375537	p.Ala144Val	missense variant	-	NC_000001.11:g.68159196G>A	ESP,ExAC,TOPMed,gnomAD
rs762774039	p.Ala144Thr	missense variant	-	NC_000001.11:g.68159197C>T	ExAC,TOPMed,gnomAD
rs759321846	p.Ala146Gly	missense variant	-	NC_000001.11:g.68159190G>C	ExAC,gnomAD
rs777451767	p.Glu147Lys	missense variant	-	NC_000001.11:g.68159188C>T	ExAC,TOPMed,gnomAD
rs772279175	p.Trp148Gly	missense variant	-	NC_000001.11:g.68159185A>C	ExAC,gnomAD
rs748429905	p.Trp148Ter	stop gained	-	NC_000001.11:g.68159184C>T	ExAC,gnomAD
COSM3805850	p.Thr149Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68159181G>A	NCI-TCGA Cosmic
rs376924151	p.Met151Ile	missense variant	-	NC_000001.11:g.68159174C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Met151Val	missense variant	-	NC_000001.11:g.68159176T>C	NCI-TCGA
rs768822401	p.Ala152Thr	missense variant	-	NC_000001.11:g.68159173C>T	ExAC,TOPMed,gnomAD
rs1034138201	p.Ala152Val	missense variant	-	NC_000001.11:g.68159172G>A	TOPMed,gnomAD
rs1367324720	p.His153Arg	missense variant	-	NC_000001.11:g.68159169T>C	gnomAD
rs1432786546	p.His153Tyr	missense variant	-	NC_000001.11:g.68159170G>A	TOPMed,gnomAD
rs897644525	p.Arg155Thr	missense variant	-	NC_000001.11:g.68159163C>G	TOPMed,gnomAD
rs749359444	p.Arg155Gly	missense variant	-	NC_000001.11:g.68159164T>C	ExAC,gnomAD
COSM426636	p.Arg158Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68159155G>C	NCI-TCGA Cosmic
rs370140589	p.Arg158Gln	missense variant	-	NC_000001.11:g.68159154C>T	ESP,ExAC,TOPMed,gnomAD
rs373149051	p.Arg158Trp	missense variant	-	NC_000001.11:g.68159155G>A	ESP,ExAC,TOPMed,gnomAD
COSM1474171	p.Leu160Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68159148A>G	NCI-TCGA Cosmic
rs781731523	p.Leu160Arg	missense variant	-	NC_000001.11:g.68159148A>C	ExAC,gnomAD
rs756953785	p.Lys161Ile	missense variant	-	NC_000001.11:g.68159145T>A	ExAC,gnomAD
rs763662898	p.Thr163Ile	missense variant	-	NC_000001.11:g.68159139G>A	ExAC,gnomAD
rs751303350	p.Thr163Pro	missense variant	-	NC_000001.11:g.68159140T>G	ExAC,gnomAD
rs1339153382	p.Ser166Phe	missense variant	-	NC_000001.11:g.68159130G>A	TOPMed
rs1421452975	p.Pro167Ser	missense variant	-	NC_000001.11:g.68159128G>A	gnomAD
rs775662852	p.Lys168Met	missense variant	-	NC_000001.11:g.68159124T>A	TOPMed
rs775662852	p.Lys168Arg	missense variant	-	NC_000001.11:g.68159124T>C	TOPMed
rs1203301417	p.Thr169Ser	missense variant	-	NC_000001.11:g.68155260T>A	gnomAD
rs554777494	p.Pro170Ser	missense variant	-	NC_000001.11:g.68155257G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs149247893	p.Glu173Asp	missense variant	-	NC_000001.11:g.68155246C>G	ESP,ExAC,TOPMed,gnomAD
rs746433942	p.Glu173Gln	missense variant	-	NC_000001.11:g.68155248C>G	ExAC,gnomAD
rs373040642	p.Arg175Cys	missense variant	-	NC_000001.11:g.68155242G>A	ESP,ExAC,TOPMed,gnomAD
rs534503973	p.Arg175His	missense variant	-	NC_000001.11:g.68155241C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs777430073	p.Tyr177His	missense variant	-	NC_000001.11:g.68155236A>G	ExAC,gnomAD
rs1411281581	p.Cys179Phe	missense variant	-	NC_000001.11:g.68155229C>A	gnomAD
rs1300394069	p.Cys179Ser	missense variant	-	NC_000001.11:g.68155230A>T	TOPMed
rs973992662	p.Asp180Gly	missense variant	-	NC_000001.11:g.68155226T>C	TOPMed
rs752250717	p.Asp180Asn	missense variant	-	NC_000001.11:g.68155227C>T	ExAC,gnomAD
rs764714551	p.Val181Asp	missense variant	-	NC_000001.11:g.68155223A>T	ExAC,TOPMed,gnomAD
rs753814975	p.Pro183Leu	missense variant	-	NC_000001.11:g.68155217G>A	ExAC,TOPMed,gnomAD
rs1470476075	p.Met185Val	missense variant	-	NC_000001.11:g.68155212T>C	gnomAD
rs1411699742	p.Met185Thr	missense variant	-	NC_000001.11:g.68155211A>G	gnomAD
rs1235240916	p.Ile187Thr	missense variant	-	NC_000001.11:g.68155205A>G	TOPMed
rs766335171	p.Ile187Val	missense variant	-	NC_000001.11:g.68155206T>C	ExAC,gnomAD
rs958517383	p.Ser189Cys	missense variant	-	NC_000001.11:g.68155199G>C	TOPMed
rs760412732	p.Val190Leu	missense variant	-	NC_000001.11:g.68155197C>A	ExAC,gnomAD
rs1440800104	p.His192Pro	missense variant	-	NC_000001.11:g.68155190T>G	gnomAD
rs750231429	p.His192Tyr	missense variant	-	NC_000001.11:g.68155191G>A	ExAC,TOPMed,gnomAD
rs764309802	p.His192Gln	missense variant	-	NC_000001.11:g.68155189A>T	ExAC,gnomAD
rs1200975329	p.Lys193Arg	missense variant	-	NC_000001.11:g.68155187T>C	gnomAD
NCI-TCGA novel	p.Leu196Arg	missense variant	-	NC_000001.11:g.68155178A>C	NCI-TCGA
rs775326068	p.Arg200Gln	missense variant	-	NC_000001.11:g.68155166C>T	ExAC,TOPMed,gnomAD
rs775625231	p.Arg200Trp	missense variant	-	NC_000001.11:g.68155167G>A	ExAC,TOPMed,gnomAD
rs775326068	p.Arg200Leu	missense variant	-	NC_000001.11:g.68155166C>A	ExAC,TOPMed,gnomAD
rs1445114253	p.Val203Met	missense variant	-	NC_000001.11:g.68155158C>T	gnomAD
rs777234549	p.Asn204Ser	missense variant	-	NC_000001.11:g.68155154T>C	ExAC,gnomAD
rs1470629139	p.Lys207Thr	missense variant	-	NC_000001.11:g.68155145T>G	TOPMed,gnomAD
rs747315006	p.Asn210Lys	missense variant	-	NC_000001.11:g.68155135A>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Asn210Ser	missense variant	-	NC_000001.11:g.68155136T>C	NCI-TCGA
rs778070396	p.Val211Leu	missense variant	-	NC_000001.11:g.68155134C>A	ExAC,gnomAD
rs778070396	p.Val211Met	missense variant	-	NC_000001.11:g.68155134C>T	ExAC,gnomAD
rs1268771388	p.Gly212Val	missense variant	-	NC_000001.11:g.68155130C>A	TOPMed
NCI-TCGA novel	p.Gly212Glu	missense variant	-	NC_000001.11:g.68155130C>T	NCI-TCGA
rs565833395	p.Ile213Thr	missense variant	-	NC_000001.11:g.68155127A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs1428205227	p.Ile216Thr	missense variant	-	NC_000001.11:g.68155118A>G	TOPMed
rs1355481712	p.Lys217Met	missense variant	-	NC_000001.11:g.68155115T>A	TOPMed
rs778457421	p.Lys217Asn	missense variant	-	NC_000001.11:g.68155114C>G	ExAC,gnomAD
rs1020037446	p.Lys217Gln	missense variant	-	NC_000001.11:g.68155116T>G	TOPMed,gnomAD
rs137997041	p.Asp218His	missense variant	-	NC_000001.11:g.68155113C>G	ESP
COSM2155293	p.Ile219Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68155108G>C	NCI-TCGA Cosmic
rs553213704	p.Arg220Gln	missense variant	-	NC_000001.11:g.68155106C>T	1000Genomes,ExAC,TOPMed,gnomAD
COSM1560514	p.Gly229Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68153634C>A	NCI-TCGA Cosmic
rs1394764795	p.Thr231Ser	missense variant	-	NC_000001.11:g.68153628G>C	TOPMed
NCI-TCGA novel	p.Lys232Asn	missense variant	-	NC_000001.11:g.68153624C>A	NCI-TCGA
rs778381265	p.Val233Met	missense variant	-	NC_000001.11:g.68153623C>T	ExAC,gnomAD
rs566622107	p.Trp234Cys	missense variant	-	NC_000001.11:g.68153618C>G	ExAC,TOPMed,gnomAD
rs1034593013	p.Trp234Leu	missense variant	-	NC_000001.11:g.68153619C>A	gnomAD
rs899145602	p.Met237Thr	missense variant	-	NC_000001.11:g.68153610A>G	TOPMed
rs1429125754	p.Met237Val	missense variant	-	NC_000001.11:g.68153611T>C	TOPMed,gnomAD
rs899145602	p.Met237Lys	missense variant	-	NC_000001.11:g.68153610A>T	TOPMed
rs1170413503	p.Phe240Leu	missense variant	-	NC_000001.11:g.68153602A>G	gnomAD
rs750375780	p.Thr242Lys	missense variant	-	NC_000001.11:g.68153595G>T	ExAC,TOPMed,gnomAD
rs750375780	p.Thr242Met	missense variant	-	NC_000001.11:g.68153595G>A	ExAC,TOPMed,gnomAD
rs535054590	p.Ile245Asn	missense variant	-	NC_000001.11:g.68153586A>T	1000Genomes,ExAC,gnomAD
rs755322764	p.Met249Ile	missense variant	-	NC_000001.11:g.68153573C>T	ExAC,TOPMed,gnomAD
rs765493613	p.Met249Val	missense variant	-	NC_000001.11:g.68153575T>C	ExAC,TOPMed,gnomAD
rs1405847168	p.Met249Thr	missense variant	-	NC_000001.11:g.68153574A>G	TOPMed,gnomAD
rs753958149	p.Trp251Cys	missense variant	-	NC_000001.11:g.68153567C>G	ExAC,TOPMed,gnomAD
rs753958149	p.Trp251Ter	stop gained	-	NC_000001.11:g.68153567C>T	ExAC,TOPMed,gnomAD
rs766617200	p.Tyr252Asn	missense variant	-	NC_000001.11:g.68153566A>T	ExAC,gnomAD
rs1276237881	p.Trp253Ter	stop gained	-	NC_000001.11:g.68153562C>T	gnomAD
rs761216330	p.Arg255Ser	missense variant	-	NC_000001.11:g.68153555C>A	ExAC,gnomAD
rs1005392323	p.Thr257Ala	missense variant	-	NC_000001.11:g.68153551T>C	TOPMed
rs201377818	p.Met258Thr	missense variant	-	NC_000001.11:g.68153547A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs200780624	p.Met258Val	missense variant	-	NC_000001.11:g.68153548T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1217791522	p.Met258Ile	missense variant	-	NC_000001.11:g.68153546C>A	gnomAD
rs762026214	p.Met259Ile	missense variant	-	NC_000001.11:g.68153543C>T	ExAC,TOPMed,gnomAD
rs1347801732	p.Met259Thr	missense variant	-	NC_000001.11:g.68153544A>G	gnomAD
rs375331655	p.Arg261Ter	stop gained	-	NC_000001.11:g.68153539G>A	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg261Gln	missense variant	-	NC_000001.11:g.68153538C>T	NCI-TCGA
rs1309994202	p.Pro262Ser	missense variant	-	NC_000001.11:g.68153536G>A	gnomAD
NCI-TCGA novel	p.Val264Leu	missense variant	-	NC_000001.11:g.68153530C>G	NCI-TCGA
rs1358464295	p.Leu266Pro	missense variant	-	NC_000001.11:g.68153523A>G	gnomAD
rs1173898074	p.Glu267Lys	missense variant	-	NC_000001.11:g.68153521C>T	gnomAD
rs199608520	p.Lys268Gln	missense variant	-	NC_000001.11:g.68153518T>G	1000Genomes,TOPMed,gnomAD
rs774684322	p.Val269Ile	missense variant	-	NC_000001.11:g.68150355C>T	ExAC,gnomAD
rs1267708910	p.Phe271Cys	missense variant	-	NC_000001.11:g.68150348A>C	gnomAD
NCI-TCGA novel	p.Phe271Ser	missense variant	-	NC_000001.11:g.68150348A>G	NCI-TCGA
rs373658553	p.Ala272Thr	missense variant	-	NC_000001.11:g.68150346C>T	ESP,ExAC,gnomAD
rs1403610407	p.Leu273Phe	missense variant	-	NC_000001.11:g.68150343G>A	TOPMed
rs549083766	p.Thr278Asn	missense variant	-	NC_000001.11:g.68150327G>T	1000Genomes,ExAC,gnomAD
rs1327555345	p.Asn281Thr	missense variant	-	NC_000001.11:g.68150318T>G	gnomAD
rs1262656316	p.Ile282Met	missense variant	-	NC_000001.11:g.68150314G>C	gnomAD
rs1240036964	p.Trp286Leu	missense variant	-	NC_000001.11:g.68150303C>A	gnomAD
rs1321192866	p.Trp286Cys	missense variant	-	NC_000001.11:g.68150302C>G	gnomAD
rs769455841	p.Ile289Val	missense variant	-	NC_000001.11:g.68150295T>C	ExAC,gnomAD
rs560637274	p.Gly290Trp	missense variant	-	NC_000001.11:g.68150292C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs560637274	p.Gly290Arg	missense variant	-	NC_000001.11:g.68150292C>T	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe291Val	missense variant	-	NC_000001.11:g.68150289A>C	NCI-TCGA
rs1319840166	p.Trp293Arg	missense variant	-	NC_000001.11:g.68150283A>G	gnomAD
rs1268574129	p.Trp295Cys	missense variant	-	NC_000001.11:g.68150275C>G	TOPMed
rs770764647	p.Met296Leu	missense variant	-	NC_000001.11:g.68150274T>G	ExAC,gnomAD
rs747019918	p.Met296Arg	missense variant	-	NC_000001.11:g.68150273A>C	ExAC,gnomAD
NCI-TCGA novel	p.Met296Thr	missense variant	-	NC_000001.11:g.68150273A>G	NCI-TCGA
rs777682277	p.Gly300Cys	missense variant	-	NC_000001.11:g.68150262C>A	ExAC,gnomAD
rs1457147736	p.Gly300Asp	missense variant	-	NC_000001.11:g.68150261C>T	gnomAD
rs758230603	p.Asp301Ala	missense variant	-	NC_000001.11:g.68150258T>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Asp301Asn	missense variant	-	NC_000001.11:g.68150259C>T	NCI-TCGA
rs780367266	p.Ile302Met	missense variant	-	NC_000001.11:g.68150254G>C	ExAC,gnomAD
rs781389796	p.Arg303Pro	missense variant	-	NC_000001.11:g.68150252C>G	ExAC,TOPMed,gnomAD
rs763193261	p.Arg303Ter	stop gained	-	NC_000001.11:g.68150253G>A	ExAC,gnomAD
rs781389796	p.Arg303Gln	missense variant	-	NC_000001.11:g.68150252C>T	ExAC,TOPMed,gnomAD
rs1463773903	p.Gly305Ala	missense variant	-	NC_000001.11:g.68150246C>G	TOPMed,gnomAD
rs1463773903	p.Gly305Asp	missense variant	-	NC_000001.11:g.68150246C>T	TOPMed,gnomAD
rs373703620	p.Ile306Val	missense variant	-	NC_000001.11:g.68150244T>C	ESP,ExAC,TOPMed,gnomAD
rs1326987421	p.Ile306Ser	missense variant	-	NC_000001.11:g.68150243A>C	gnomAD
rs146556198	p.Tyr308Phe	missense variant	-	NC_000001.11:g.68150237T>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs764615459	p.Ala309Val	missense variant	-	NC_000001.11:g.68150234G>A	ExAC,TOPMed,gnomAD
rs1224758616	p.Met310Thr	missense variant	-	NC_000001.11:g.68150231A>G	gnomAD
rs753071006	p.Leu311Phe	missense variant	-	NC_000001.11:g.68150229G>A	ExAC,gnomAD
rs374500512	p.Ile316Phe	missense variant	-	NC_000001.11:g.68150214T>A	ESP,ExAC,gnomAD
COSM4009683	p.Glu321Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68150199C>T	NCI-TCGA Cosmic
rs1198782090	p.Asp325Asn	missense variant	-	NC_000001.11:g.68148660C>T	TOPMed
rs759083110	p.Asp325Val	missense variant	-	NC_000001.11:g.68148659T>A	ExAC,TOPMed,gnomAD
rs1435104565	p.His327Tyr	missense variant	-	NC_000001.11:g.68148654G>A	TOPMed
rs149826196	p.His327Gln	missense variant	-	NC_000001.11:g.68148652G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs760206984	p.Glu328Lys	missense variant	-	NC_000001.11:g.68148651C>T	ExAC,TOPMed,gnomAD
rs183229421	p.Arg329Trp	missense variant	-	NC_000001.11:g.68148648G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs150664610	p.Arg329Gln	missense variant	-	NC_000001.11:g.68148647C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs761900253	p.Asn330Ser	missense variant	-	NC_000001.11:g.68148644T>C	ExAC,gnomAD
rs1251082677	p.His331Tyr	missense variant	-	NC_000001.11:g.68148642G>A	gnomAD
rs773993560	p.Ile332Val	missense variant	-	NC_000001.11:g.68148639T>C	ExAC,gnomAD
rs768536303	p.Ile332Asn	missense variant	-	NC_000001.11:g.68148638A>T	ExAC,gnomAD
rs17130529	p.Ile332Met	missense variant	-	NC_000001.11:g.68148637G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs368391265	p.Ala333Thr	missense variant	-	NC_000001.11:g.68148636C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs368391265	p.Ala333Ser	missense variant	-	NC_000001.11:g.68148636C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1204173995	p.Ala333Val	missense variant	-	NC_000001.11:g.68148635G>A	TOPMed,gnomAD
rs191705869	p.Gly334Glu	missense variant	-	NC_000001.11:g.68148632C>T	1000Genomes
rs1302443592	p.Trp336Ter	stop gained	-	NC_000001.11:g.68148626C>T	TOPMed
rs760112523	p.Gln338Leu	missense variant	-	NC_000001.11:g.68148620T>A	ExAC,gnomAD
rs760112523	p.Gln338Arg	missense variant	-	NC_000001.11:g.68148620T>C	ExAC,gnomAD
rs758885772	p.Val339Ile	missense variant	-	NC_000001.11:g.68148618C>T	ExAC,gnomAD
rs755325364	p.Gly340Arg	missense variant	-	NC_000001.11:g.68148615C>T	ExAC,TOPMed,gnomAD
rs765990145	p.Ile342Thr	missense variant	-	NC_000001.11:g.68148608A>G	ExAC,TOPMed,gnomAD
rs754260821	p.Val344Phe	missense variant	-	NC_000001.11:g.68148603C>A	ExAC,TOPMed,gnomAD
rs754260821	p.Val344Ile	missense variant	-	NC_000001.11:g.68148603C>T	ExAC,TOPMed,gnomAD
rs1471162847	p.Val344Ala	missense variant	-	NC_000001.11:g.68148602A>G	gnomAD
rs1489605832	p.Gly345Ser	missense variant	-	NC_000001.11:g.68148600C>T	TOPMed
rs761809939	p.Ser346Phe	missense variant	-	NC_000001.11:g.68148596G>A	ExAC,gnomAD
rs1459962353	p.Phe347Ser	missense variant	-	NC_000001.11:g.68148593A>G	gnomAD
rs774305005	p.Phe347Leu	missense variant	-	NC_000001.11:g.68148594A>G	ExAC,gnomAD
NCI-TCGA novel	p.Phe347Val	missense variant	-	NC_000001.11:g.68148594A>C	NCI-TCGA
rs763960267	p.Cys348Arg	missense variant	-	NC_000001.11:g.68148591A>G	ExAC,gnomAD
rs762748650	p.Ile351Val	missense variant	-	NC_000001.11:g.68148582T>C	ExAC,gnomAD
COSM911865	p.Asp353Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68148576C>A	NCI-TCGA Cosmic
rs1464290583	p.Asp353Gly	missense variant	-	NC_000001.11:g.68148575T>C	gnomAD
rs771136118	p.Met354Val	missense variant	-	NC_000001.11:g.68148573T>C	ExAC,gnomAD
rs747286814	p.Cys355Tyr	missense variant	-	NC_000001.11:g.68148569C>T	ExAC,TOPMed,gnomAD
COSM4838318	p.Arg357Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68148563C>T	NCI-TCGA Cosmic
rs1244691536	p.Leu361Phe	missense variant	-	NC_000001.11:g.68148189G>A	gnomAD
rs200839533	p.Thr362Met	missense variant	-	NC_000001.11:g.68148185G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Thr362Pro	missense variant	-	NC_000001.11:g.68148186T>G	NCI-TCGA
rs1323164865	p.Pro364Ala	missense variant	-	NC_000001.11:g.68148180G>C	gnomAD
rs1267796107	p.Ser367Gly	missense variant	-	NC_000001.11:g.68148171T>C	TOPMed
rs769194665	p.Ile368Thr	missense variant	-	NC_000001.11:g.68148167A>G	ExAC,gnomAD
rs749809422	p.Trp369Leu	missense variant	-	NC_000001.11:g.68148164C>A	ExAC,gnomAD
rs377649019	p.Thr370Ile	missense variant	-	NC_000001.11:g.68148161G>A	ESP,ExAC,TOPMed,gnomAD
rs1448847233	p.Thr370Ala	missense variant	-	NC_000001.11:g.68148162T>C	gnomAD
rs770242439	p.Asp372Asn	missense variant	-	NC_000001.11:g.68148156C>T	ExAC,gnomAD
rs950142058	p.Ile373Val	missense variant	-	NC_000001.11:g.68148153T>C	TOPMed,gnomAD
rs746256483	p.Ile373Thr	missense variant	-	NC_000001.11:g.68148152A>G	ExAC,gnomAD
rs1196841907	p.Gly374Arg	missense variant	-	NC_000001.11:g.68148150C>T	gnomAD
rs1490697114	p.Thr375Ala	missense variant	-	NC_000001.11:g.68148147T>C	gnomAD
rs780933286	p.Leu377Pro	missense variant	-	NC_000001.11:g.68148140A>G	ExAC,gnomAD
rs1157974780	p.Met379Thr	missense variant	-	NC_000001.11:g.68146011A>G	gnomAD
rs1167594366	p.Ile382Val	missense variant	-	NC_000001.11:g.68146003T>C	gnomAD
rs541018004	p.Val384Met	missense variant	-	NC_000001.11:g.68145997C>T	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ile387Phe	missense variant	-	NC_000001.11:g.68145988T>A	NCI-TCGA
rs762882816	p.Cys390Tyr	missense variant	-	NC_000001.11:g.68145978C>T	ExAC,gnomAD
rs775714644	p.Phe393Ile	missense variant	-	NC_000001.11:g.68145970A>T	ExAC,gnomAD
rs1224245364	p.Met399Leu	missense variant	-	NC_000001.11:g.68145952T>G	TOPMed,gnomAD
rs1224245364	p.Met399Val	missense variant	-	NC_000001.11:g.68145952T>C	TOPMed,gnomAD
rs1381900985	p.Val400Ala	missense variant	-	NC_000001.11:g.68145948A>G	gnomAD
COSM911863	p.Phe401Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68145944A>C	NCI-TCGA Cosmic
rs747426311	p.Gln402Pro	missense variant	-	NC_000001.11:g.68145942T>G	ExAC,gnomAD
rs771236969	p.Gln402Lys	missense variant	-	NC_000001.11:g.68145943G>T	ExAC,gnomAD
rs969490308	p.Val403Leu	missense variant	-	NC_000001.11:g.68145940C>G	TOPMed
NCI-TCGA novel	p.Val403Ala	missense variant	-	NC_000001.11:g.68145939A>G	NCI-TCGA
rs200028453	p.Arg405Gln	missense variant	-	NC_000001.11:g.68145933C>T	ExAC,TOPMed,gnomAD
rs772685057	p.Arg405Trp	missense variant	-	NC_000001.11:g.68145934G>A	ExAC,TOPMed,gnomAD
rs747655642	p.Ile407Val	missense variant	-	NC_000001.11:g.68145928T>C	ExAC,gnomAD
rs1006464584	p.Ser408Arg	missense variant	-	NC_000001.11:g.68145923A>C	gnomAD
rs1377523062	p.Gly409Ala	missense variant	-	NC_000001.11:g.68145921C>G	TOPMed
COSM464899	p.Lys410Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68145919T>C	NCI-TCGA Cosmic
rs374389935	p.Ser413Arg	missense variant	-	NC_000001.11:g.68145908G>C	ExAC,TOPMed,gnomAD
rs749265229	p.Ala416Val	missense variant	-	NC_000001.11:g.68145900G>A	ExAC,gnomAD
rs780072895	p.Met417Lys	missense variant	-	NC_000001.11:g.68145897A>T	ExAC,gnomAD
rs755815093	p.Ser418Gly	missense variant	-	NC_000001.11:g.68145895T>C	ExAC,gnomAD
rs1244195134	p.Ser418Arg	missense variant	-	NC_000001.11:g.68145893G>T	gnomAD
COSM5673041	p.Arg421Trp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68145886G>A	NCI-TCGA Cosmic
rs750244529	p.Arg421Gln	missense variant	-	NC_000001.11:g.68145885C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg421Gly	missense variant	-	NC_000001.11:g.68145886G>C	NCI-TCGA
rs202076524	p.Arg422Trp	missense variant	-	NC_000001.11:g.68145883G>A	ExAC,gnomAD
rs763172046	p.Arg422Gln	missense variant	-	NC_000001.11:g.68145882C>T	ExAC,TOPMed,gnomAD
rs777234805	p.His424Arg	missense variant	-	NC_000001.11:g.68145876T>C	ExAC,TOPMed,gnomAD
rs777234805	p.His424Leu	missense variant	-	NC_000001.11:g.68145876T>A	ExAC,TOPMed,gnomAD
rs888029073	p.Tyr425His	missense variant	-	NC_000001.11:g.68145874A>G	gnomAD
rs1392022977	p.Gly427Glu	missense variant	-	NC_000001.11:g.68144651C>T	gnomAD
rs773427249	p.Ile429Thr	missense variant	-	NC_000001.11:g.68144645A>G	ExAC
NCI-TCGA novel	p.Phe430LeuPheSerTerUnkUnk	frameshift	-	NC_000001.11:g.68144641A>-	NCI-TCGA
rs150138976	p.Lys433Arg	missense variant	-	NC_000001.11:g.68144633T>C	ESP,ExAC,TOPMed,gnomAD
rs1480258381	p.Phe434Ser	missense variant	-	NC_000001.11:g.68144630A>G	gnomAD
rs773945533	p.Leu437Phe	missense variant	-	NC_000001.11:g.68144622G>A	ExAC,TOPMed,gnomAD
rs768308570	p.Ile438Val	missense variant	-	NC_000001.11:g.68144619T>C	ExAC,gnomAD
rs1341195155	p.Leu440Val	missense variant	-	NC_000001.11:g.68144613A>C	gnomAD
rs889137737	p.Ala441Ser	missense variant	-	NC_000001.11:g.68144610C>A	gnomAD
rs889137737	p.Ala441Thr	missense variant	-	NC_000001.11:g.68144610C>T	gnomAD
rs1222493713	p.Ala441Val	missense variant	-	NC_000001.11:g.68144609G>A	gnomAD
rs769604518	p.Cys442Tyr	missense variant	-	NC_000001.11:g.68144606C>T	ExAC,gnomAD
rs770806676	p.Ala443Thr	missense variant	-	NC_000001.11:g.68144604C>T	ExAC,gnomAD
rs770806676	p.Ala443Pro	missense variant	-	NC_000001.11:g.68144604C>G	ExAC,gnomAD
rs1334662559	p.Ala444Asp	missense variant	-	NC_000001.11:g.68144600G>T	gnomAD
COSM911861	p.Met445Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68144597A>G	NCI-TCGA Cosmic
rs746820319	p.Met445Ile	missense variant	-	NC_000001.11:g.68144596C>G	ExAC,gnomAD
rs201544180	p.Ile451Met	missense variant	-	NC_000001.11:g.68144578G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs778142595	p.Val452Ile	missense variant	-	NC_000001.11:g.68144577C>T	ExAC,TOPMed,gnomAD
rs778142595	p.Val452Phe	missense variant	-	NC_000001.11:g.68144577C>A	ExAC,TOPMed,gnomAD
rs1371106483	p.Ser453Thr	missense variant	-	NC_000001.11:g.68144573C>G	TOPMed
rs1371106483	p.Ser453Asn	missense variant	-	NC_000001.11:g.68144573C>T	TOPMed
rs1332510685	p.Gln454His	missense variant	-	NC_000001.11:g.68144569C>G	gnomAD
rs1199720466	p.Val455Ile	missense variant	-	NC_000001.11:g.68137933C>T	TOPMed
rs140465138	p.Thr456Met	missense variant	-	NC_000001.11:g.68137929G>A	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.His459Gln	missense variant	-	NC_000001.11:g.68137919A>C	NCI-TCGA
rs764816861	p.Trp462Arg	missense variant	-	NC_000001.11:g.68137912A>G	ExAC,gnomAD
rs1402456775	p.Gly463Arg	missense variant	-	NC_000001.11:g.68137909C>G	TOPMed,gnomAD
COSM6127157	p.Gly464Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68137906C>A	NCI-TCGA Cosmic
rs1162833281	p.Gly464Ser	missense variant	-	NC_000001.11:g.68137906C>T	gnomAD
rs983034	p.Val465Ile	missense variant	-	NC_000001.11:g.68137903C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Thr466Ala	missense variant	-	NC_000001.11:g.68137900T>C	NCI-TCGA
rs1474972960	p.Val467Ile	missense variant	-	NC_000001.11:g.68137897C>T	TOPMed,gnomAD
COSM3492052	p.Gln468Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000001.11:g.68137894G>A	NCI-TCGA Cosmic
rs1400480877	p.Gln468Arg	missense variant	-	NC_000001.11:g.68137893T>C	TOPMed
rs747919046	p.Gln468His	missense variant	-	NC_000001.11:g.68137892T>A	ExAC,gnomAD
rs1400480877	p.Gln468Pro	missense variant	-	NC_000001.11:g.68137893T>G	TOPMed
rs1488328865	p.Ser471Asn	missense variant	-	NC_000001.11:g.68137884C>T	TOPMed,gnomAD
rs1488328865	p.Ser471Thr	missense variant	-	NC_000001.11:g.68137884C>G	TOPMed,gnomAD
rs1290466762	p.Ala472Val	missense variant	-	NC_000001.11:g.68137881G>A	gnomAD
NCI-TCGA novel	p.Phe474SerPheSerTerUnkUnk	frameshift	-	NC_000001.11:g.68137875A>-	NCI-TCGA
rs775725554	p.Ile477Leu	missense variant	-	NC_000001.11:g.68137867T>G	ExAC,gnomAD
rs985347096	p.Tyr478Cys	missense variant	-	NC_000001.11:g.68137863T>C	TOPMed,gnomAD
rs1292674921	p.Met480Thr	missense variant	-	NC_000001.11:g.68137857A>G	gnomAD
rs1229194863	p.Asn482His	missense variant	-	NC_000001.11:g.68137852T>G	gnomAD
rs1339147174	p.Ala487Val	missense variant	-	NC_000001.11:g.68137836G>A	gnomAD
rs142571662	p.Met489Ile	missense variant	-	NC_000001.11:g.68137829C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs745953882	p.Met489Thr	missense variant	-	NC_000001.11:g.68137830A>G	ExAC,gnomAD
rs1302671362	p.Tyr492Cys	missense variant	-	NC_000001.11:g.68137821T>C	gnomAD
rs1367314990	p.Pro494Ser	missense variant	-	NC_000001.11:g.68137816G>A	gnomAD
COSM3805842	p.Lys497Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68137806T>G	NCI-TCGA Cosmic
rs778280457	p.Asn498His	missense variant	-	NC_000001.11:g.68137804T>G	ExAC,gnomAD
rs367885134	p.Tyr499Cys	missense variant	-	NC_000001.11:g.68137800T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs753014700	p.Gly500Arg	missense variant	-	NC_000001.11:g.68137798C>T	ExAC,TOPMed,gnomAD
rs1267776678	p.Asn505Asp	missense variant	-	NC_000001.11:g.68137783T>C	gnomAD
rs764940216	p.Asn505Thr	missense variant	-	NC_000001.11:g.68137782T>G	ExAC,TOPMed,gnomAD
rs764940216	p.Asn505Ser	missense variant	-	NC_000001.11:g.68137782T>C	ExAC,TOPMed,gnomAD
COSM5100846	p.Gly506Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.68126335C>T	NCI-TCGA Cosmic
rs762768486	p.Gly506Val	missense variant	-	NC_000001.11:g.68126335C>A	ExAC,gnomAD
rs142863298	p.Asp507Asn	missense variant	-	NC_000001.11:g.68126333C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs142863298	p.Asp507His	missense variant	-	NC_000001.11:g.68126333C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs772610769	p.Gly509Ser	missense variant	-	NC_000001.11:g.68126327C>T	ExAC,TOPMed,gnomAD
rs1251638197	p.Val510Ile	missense variant	-	NC_000001.11:g.68126324C>T	TOPMed
rs374994390	p.Gly513Ala	missense variant	-	NC_000001.11:g.68126314C>G	ESP,ExAC,gnomAD
NCI-TCGA novel	p.Gly513Glu	missense variant	-	NC_000001.11:g.68126314C>T	NCI-TCGA
rs779506116	p.Glu514Lys	missense variant	-	NC_000001.11:g.68126312C>T	ExAC,gnomAD
rs1358701011	p.Glu515Lys	missense variant	-	NC_000001.11:g.68126309C>T	TOPMed
rs371753437	p.Leu516Phe	missense variant	-	NC_000001.11:g.68126306G>A	ESP,ExAC,TOPMed,gnomAD
rs80319761	p.Leu518Pro	missense variant	-	NC_000001.11:g.68126299A>G	gnomAD
rs749937551	p.Thr519Pro	missense variant	-	NC_000001.11:g.68126297T>G	ExAC,TOPMed,gnomAD
rs749937551	p.Thr519Ala	missense variant	-	NC_000001.11:g.68126297T>C	ExAC,TOPMed,gnomAD
rs757184468	p.Thr520Ile	missense variant	-	NC_000001.11:g.68126293G>A	ExAC,gnomAD
rs1490354675	p.Val525Gly	missense variant	-	NC_000001.11:g.68126278A>C	TOPMed
NCI-TCGA novel	p.Asp526Gly	missense variant	-	NC_000001.11:g.68126275T>C	NCI-TCGA
rs764113746	p.Gly527Arg	missense variant	-	NC_000001.11:g.68126273C>T	ExAC,TOPMed,gnomAD
rs1208787795	p.Thr529Ser	missense variant	-	NC_000001.11:g.68126267T>A	gnomAD
rs752492386	p.Glu530Asp	missense variant	-	NC_000001.11:g.68126262C>G	ExAC,gnomAD
rs1211633783	p.Lys533Thr	missense variant	-	NC_000001.11:g.68126254T>G	gnomAD
rs773311381	p.Arg536Cys	missense variant	-	NC_000001.11:g.68126246G>A	ExAC,gnomAD
rs1319499255	p.Lys537Asn	missense variant	-	NC_000001.11:g.68126241C>A	gnomAD
rs1278458589	p.Glu538Lys	missense variant	-	NC_000001.11:g.68126240C>T	gnomAD
NCI-TCGA novel	p.Gln540Arg	missense variant	-	NC_000001.11:g.68126233T>C	NCI-TCGA

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0004114	Astrocytoma	disease	BEFREE
C0004364	Autoimmune Diseases	group	BEFREE
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE
C0005699	Blast Phase	disease	BEFREE
C0005890	Body Height	phenotype	GWASDB
C0005938	Bone Density	phenotype	GWASCAT;GWASDB
C0005941	Bone Diseases, Developmental	group	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0007095	Carcinoid Tumor	group	BEFREE
C0007102	Malignant tumor of colon	disease	BEFREE
C0007103	Malignant neoplasm of endometrium	disease	BEFREE
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE
C0007134	Renal Cell Carcinoma	disease	BEFREE
C0007137	Squamous cell carcinoma	disease	BEFREE
C0007138	Carcinoma, Transitional Cell	disease	BEFREE
C0008312	Primary biliary cirrhosis	disease	BEFREE
C0009402	Colorectal Carcinoma	disease	BEFREE
C0014859	Esophageal Neoplasms	group	BEFREE
C0017636	Glioblastoma	disease	BEFREE
C0017638	Glioma	disease	BEFREE
C0022350	Jaundice, Chronic Idiopathic	disease	BEFREE
C0023418	leukemia	disease	BEFREE
C0023434	Chronic Lymphocytic Leukemia	disease	BEFREE
C0023443	Hairy Cell Leukemia	disease	BEFREE
C0023449	Acute lymphocytic leukemia	disease	BEFREE
C0023465	Acute monocytic leukemia	disease	BEFREE
C0023467	Leukemia, Myelocytic, Acute	disease	BEFREE
C0023486	Prolymphocytic Leukemia	disease	BEFREE
C0023530	Leukopenia	disease	BEFREE
C0023646	Lichen Planus	disease	BEFREE
C0023893	Liver Cirrhosis, Experimental	disease	CTD_human
C0024121	Lung Neoplasms	group	BEFREE
C0024299	Lymphoma	group	BEFREE
C0024305	Lymphoma, Non-Hodgkin	disease	BEFREE
C0024314	Lymphoproliferative Disorders	group	BEFREE
C0024530	Malaria	disease	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0025149	Medulloblastoma	disease	BEFREE
C0025202	melanoma	disease	BEFREE
C0025500	Mesothelioma	disease	BEFREE
C0026764	Multiple Myeloma	disease	BEFREE
C0027627	Neoplasm Metastasis	phenotype	BEFREE
C0027794	Neural Tube Defects	group	BEFREE
C0027819	Neuroblastoma	group	BEFREE
C0029453	Osteopenia	disease	BEFREE
C0029463	Osteosarcoma	disease	BEFREE
C0029925	Ovarian Carcinoma	disease	BEFREE
C0031154	Peritonitis	disease	BEFREE
C0033860	Psoriasis	disease	BEFREE
C0036220	Kaposi Sarcoma	disease	BEFREE
C0079772	T-Cell Lymphoma	disease	BEFREE
C0085669	Acute leukemia	disease	BEFREE
C0149925	Small cell carcinoma of lung	disease	BEFREE
C0152013	Adenocarcinoma of lung (disorder)	disease	BEFREE
C0152018	Esophageal carcinoma	disease	BEFREE
C0153392	Malignant neoplasm of nasopharynx	disease	BEFREE
C0153676	Secondary malignant neoplasm of lung	disease	BEFREE
C0206677	Adenomatous Polyps	disease	BEFREE
C0206698	Cholangiocarcinoma	disease	BEFREE
C0220615	Adult Acute Myeloblastic Leukemia	disease	BEFREE
C0220748	Cartilage-hair hypoplasia	disease	BEFREE
C0235974	Pancreatic carcinoma	disease	BEFREE
C0238301	Cancer of Nasopharynx	disease	BEFREE
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0265289	Metaphyseal chondrodysplasia Schmid type	disease	BEFREE
C0268307	Conjugated hyperbilirubinemia	disease	BEFREE
C0276535	AIDS with Kaposi's sarcoma	disease	BEFREE
C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	disease	BEFREE
C0279651	Gallbladder adenocarcinoma	disease	BEFREE
C0280100	Solid Neoplasm	phenotype	BEFREE
C0334299	Carcinoid tumor no ICD-O subtype	phenotype	BEFREE
C0334579	Anaplastic astrocytoma	disease	BEFREE
C0345904	Malignant neoplasm of liver	disease	BEFREE
C0345958	Large cell carcinoma of lung	disease	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0376544	Hematopoietic Neoplasms	group	BEFREE
C0376545	Hematologic Neoplasms	group	BEFREE
C0476089	Endometrial Carcinoma	disease	BEFREE
C0546837	Malignant neoplasm of esophagus	disease	BEFREE
C0555971	Oral infection	group	BEFREE
C0585442	Osteosarcoma of bone	disease	BEFREE
C0585474	Ewing's sarcoma of bone	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0677936	Refractory cancer	phenotype	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0684249	Carcinoma of lung	disease	BEFREE
C0685938	Malignant neoplasm of gastrointestinal tract	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0700095	Central neuroblastoma	disease	BEFREE
C0750952	Biliary Tract Cancer	disease	BEFREE
C0858355	Addicted to cocaine	phenotype	BEFREE;PSYGENET
C0919267	ovarian neoplasm	disease	BEFREE
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1264606	Persistent infection	phenotype	BEFREE
C1279296	Chronic leukemia (category)	disease	BEFREE
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1458155	Mammary Neoplasms	group	BEFREE
C1527249	Colorectal Cancer	disease	BEFREE
C1861305	TARSAL-CARPAL COALITION SYNDROME	disease	BEFREE
C1861502	COLCHICINE RESISTANCE	phenotype	BEFREE
C1883486	Uterine Corpus Cancer	disease	BEFREE
C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE
C2931822	Nasopharyngeal carcinoma	disease	BEFREE
C4086165	Childhood Neuroblastoma	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005515	protein binding	IPI
GO:0017147	Wnt-protein binding	ISS
GO:0017147	Wnt-protein binding	IBA
GO:0017147	Wnt-protein binding	IPI
GO:0031852	mu-type opioid receptor binding	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001707	mesoderm formation	IEA
GO:0006886	intracellular protein transport	IMP
GO:0006886	intracellular protein transport	IBA
GO:0009948	anterior/posterior axis specification	ISS
GO:0016055	Wnt signaling pathway	ISS
GO:0016055	Wnt signaling pathway	TAS
GO:0030177	positive regulation of Wnt signaling pathway	IMP
GO:0030901	midbrain development	IEA
GO:0030902	hindbrain development	IEA
GO:0031017	exocrine pancreas development	IEA
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISS
GO:0061355	Wnt protein secretion	IBA
GO:0061355	Wnt protein secretion	IMP
GO:0061357	positive regulation of Wnt protein secretion	IMP
GO:0061357	positive regulation of Wnt protein secretion	ISS
GO:0090263	positive regulation of canonical Wnt signaling pathway	IMP

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0000139	Golgi membrane	TAS
GO:0005769	early endosome	IDA
GO:0005783	endoplasmic reticulum	IDA
GO:0005789	endoplasmic reticulum membrane	IEA
GO:0005794	Golgi apparatus	IDA
GO:0005802	trans-Golgi network	IDA
GO:0005829	cytosol	IDA
GO:0005886	plasma membrane	IDA
GO:0005886	plasma membrane	TAS
GO:0012505	endomembrane system	IBA
GO:0030666	endocytic vesicle membrane	TAS
GO:0031301	integral component of organelle membrane	IBA
GO:0031410	cytoplasmic vesicle	IDA
GO:0031901	early endosome membrane	TAS
GO:0032590	dendrite membrane	IEA
GO:0032839	dendrite cytoplasm	IEA
GO:0070062	extracellular exosome	TAS

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-3238698	WNT ligand biogenesis and trafficking	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of WLS mRNA	24810058
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of WLS mRNA	25380136
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene results in increased expression of WLS mRNA	20406850
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of WLS mRNA	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA	27188386
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of WLS mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of WLS mRNA]	17585979
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of WLS gene	27153756
D001151	Arsenic	Arsenic affects the methylation of WLS gene	25304211
D001280	Atrazine	Atrazine results in increased expression of WLS mRNA	22378314
D001280	Atrazine	Atrazine results in increased expression of WLS mRNA	27614199
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the methylation of WLS intron	30157460
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of WLS mRNA	22228805
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of WLS mRNA	30951980
C006780	bisphenol A	bisphenol A results in decreased expression of WLS mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased methylation of WLS gene	22576693
C006780	bisphenol A	bisphenol A results in increased expression of WLS mRNA	30951980
C006780	bisphenol A	bisphenol A affects the expression of WLS mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of WLS mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of WLS mRNA	30816183
C000611646	bisphenol F	bisphenol F results in increased expression of WLS mRNA	30951980
D002220	Carbamazepine	Carbamazepine affects the expression of WLS mRNA	25979313
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of WLS mRNA	23650126
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WLS mRNA	20938992
D002945	Cisplatin	Cisplatin affects the expression of WLS mRNA	23300844
D002945	Cisplatin	Cisplatin results in decreased expression of WLS mRNA	22023808
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of WLS mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of WLS mRNA]	17585979
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of WLS mRNA	19376846
D003300	Copper	Copper results in increased expression of WLS mRNA	30556269
D003471	Cuprizone	Cuprizone results in increased expression of WLS mRNA	26577399
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of WLS mRNA	31326446
D000077209	Decitabine	Decitabine affects the expression of WLS mRNA	23300844
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of WLS mRNA	21266533
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of WLS mRNA	19638242
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of WLS mRNA	25380136
C516138	dorsomorphin	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA	27188386
D004726	Endosulfan	Endosulfan results in decreased expression of WLS mRNA	29391264
C118739	entinostat	entinostat results in increased expression of WLS mRNA	27188386
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of WLS mRNA	20660070
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of WLS mRNA	26865667
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WLS mRNA	20938992
C039281	furan	furan results in increased expression of WLS mRNA	27387713
D019833	Genistein	Genistein affects the expression of WLS mRNA	26865667
C492448	ICG 001	ICG 001 results in decreased expression of WLS mRNA	26191083
D008694	Methamphetamine	Methamphetamine affects the expression of WLS mRNA	29802913
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WLS mRNA	20938992
C005219	methyl cellosolve	methyl cellosolve results in increased expression of WLS mRNA	21061450
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of WLS mRNA	28001369
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of WLS mRNA	24128854
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of WLS mRNA	31059758
D000077150	Oxaliplatin	[Oxaliplatin co-treated with Topotecan] results in increased expression of WLS mRNA	25729387
D000077767	Panobinostat	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA	27188386
D010634	Phenobarbital	Phenobarbital affects the expression of WLS mRNA	23091169
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of WLS mRNA	26272509
D010795	Phthalic Acids	Phthalic Acids results in increased expression of WLS mRNA	21061450
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of WLS mRNA	19710929
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of WLS mRNA	20660070
C005556	propionaldehyde	propionaldehyde results in increased expression of WLS mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of WLS mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of WLS mRNA	27029645
D012402	Rotenone	Rotenone results in decreased expression of WLS mRNA	29955902
D012715	Sesame Oil	Sesame Oil results in decreased expression of WLS mRNA	29191790
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of WLS mRNA	25895662
C017947	sodium arsenite	sodium arsenite affects the methylation of WLS gene	28589171
D012999	Soman	Soman results in increased expression of WLS mRNA	19281266
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of WLS mRNA	31326446
C041181	tetrachlorodian	tetrachlorodian results in decreased expression of WLS mRNA	31326446
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of WLS mRNA	17101203
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of WLS mRNA	21570461
D013893	Thiram	Thiram results in increased expression of WLS mRNA	20530235
C009495	titanium dioxide	titanium dioxide results in increased expression of WLS mRNA	23409001; 23557971;
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of WLS mRNA	28065790
D019772	Topotecan	[Oxaliplatin co-treated with Topotecan] results in increased expression of WLS mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of WLS mRNA	21934132
D014284	Triiodothyronine	Triiodothyronine results in increased expression of WLS mRNA	23397585
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of WLS mRNA	19042947
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of WLS mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of WLS gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of WLS mRNA	23179753; 26272509; 27188386;
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of WLS gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of WLS mRNA	22570695
D014810	Vitamin E	Vitamin E results in increased expression of WLS mRNA	19244175
D000077211	Zoledronic Acid	Zoledronic Acid results in decreased expression of WLS mRNA	24714768

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-1003	Cell membrane
KW-0968	Cytoplasmic vesicle
KW-0217	Developmental protein
KW-0256	Endoplasmic reticulum
KW-0967	Endosome
KW-0325	Glycoprotein
KW-0333	Golgi apparatus
KW-0472	Membrane
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0812	Transmembrane
KW-1133	Transmembrane helix
KW-0879	Wnt signaling pathway

Interpro

InterPro ID	InterPro Term
IPR009551	Wntless

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term

Gene: WLS

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction