| Tag | Content |
|---|---|
| Uniprot ID | Q61060 |
| Entrez ID | 15221 |
| Genbank protein ID | AAA87569.1; AAC28352.2; |
| Genbank nucleotide ID | NM_010425.3 |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Forkhead box protein D3 |
| Gene symbol | Foxd3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 18367558; 21254333; |
| Functional description | Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. |
| Sequence | MTLSGSGSAS DMSGQTVLTA EDVDIDVVGE GDDGLEEKDS DAGCDSPAGP PDLRLDEADE 60 GPPVSAHHGQ SQPQALALPT EATGPGNDTG APEADGCKGG EDAVTGGGGP GAGSGATGGL 120 TPNKPKNSLV KPPYSYIALI TMAILQSPQK KLTLSGICEF ISNRFPYYRE KFPAWQNSIR 180 HNLSLNDCFV KIPREPGNPG KGNYWTLDPQ SEDMFDNGSF LRRRKRFKRH QQEHLREQTA 240 LMMQSFGAYS LAAAAGAGPY GLHPAAAAGA YSHPAAAAAA AAAAALQYPY ALPPVAPVLP 300 PAVPLLPSGE LGRKAAAFGS QLGPSLQLQL NTLGAAAAAA GTAGAAGTTS LIKSEPSARP 360 SFSIENIIGA GSAAPGGSAG GGGSGGGAGG GGGSGGGGGA QSFLRPPGTV QSAALMATHQ 420 PLSLSRTTAT IAPILSVPLS GQFLQPAASA AAAAAAAVQA KWPAQ 465 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | ISO |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IBA |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | ISO |
| GO:0003677 | DNA binding | ISO |
| GO:0003690 | double-stranded DNA binding | ISO |
| GO:0003700 | DNA-binding transcription factor activity | IDA |
| GO:0044212 | transcription regulatory region DNA binding | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0001701 | in utero embryonic development | IDA |
| GO:0001829 | trophectodermal cell differentiation | IMP |
| GO:0001892 | embryonic placenta development | IMP |
| GO:0006351 | transcription, DNA-templated | TAS |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA |
| GO:0009653 | anatomical structure morphogenesis | IBA |
| GO:0030154 | cell differentiation | IBA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISS |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:1990830 | cellular response to leukemia inhibitory factor | IEP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000790 | nuclear chromatin | ISO |
| GO:0005634 | nucleus | IBA |
| GO:0005634 | nucleus | IC |
| GO:0005667 | transcription factor complex | TAS |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF00250 | Forkhead |