| Tag | Content |
|---|---|
| Uniprot ID | Q61879; Q5SV63; |
| Entrez ID | 77579 |
| Genbank protein ID | AAH89011.1; AAA84879.1; |
| Genbank nucleotide ID | NM_175260.2 |
| Ensembl protein ID | ENSMUSP00000099671 |
| Ensembl nucleotide ID | ENSMUSG00000020900 |
| Gene name | Myosin-10 |
| Gene symbol | Myh10 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 25807483 |
| Functional description | Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. |
| Sequence | MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 60 ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 120 FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 180 GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS 240 RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL 300 LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS 360 FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA 420 VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN 480 EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW 540 FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN 600 DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES 660 LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV 720 FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE 780 ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK 840 VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET 900 ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD 960 EEEGARQKLQ LEKVTAEAKI KKMEEEVLLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE 1020 KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQVDE 1080 LKVQLTKKEE ELQGALARGD DETLHKNNAL KVARELQAQI AELQEDFESE KASRNKAEKQ 1140 KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEDETKNH EAQIQDMRQR 1200 HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ 1260 VQELHAKVSE GDRLRVELAE KANKLQNELD NVSTLLEEAE KKGIKFAKDA AGLESQLQDT 1320 QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV 1380 DDDLGTIESL EEAKKKLLKD VEALSQRLEE KVLAYDKLEK TKNRLQQELD DLTVDLDHQR 1440 QIVSNLEKKQ KKFDQLLAEE KGISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE 1500 EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED 1560 AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLLKQVRE LEAELEDERK QRALAVASKK 1620 KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK 1680 KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEIANS ASGKSALLDE KRRLEARIAQ 1740 LEEELEEEQS NMELLNDRFR KTTLQVDTLN TELAAERSAA QKSDNARQQL ERQNKELKAK 1800 LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED 1860 ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE 1920 VSTLKNRLRR GGPISFSSSR SGRRQLHIEG ASLELSDDDT ESKTSDVNDT QPPQSE 1976 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000146 | microfilament motor activity | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0005516 | calmodulin binding | IEA |
| GO:0005524 | ATP binding | ISO |
| GO:0016887 | ATPase activity | ISO |
| GO:0030898 | actin-dependent ATPase activity | ISO |
| GO:0035613 | RNA stem-loop binding | ISO |
| GO:0042802 | identical protein binding | ISO |
| GO:0043531 | ADP binding | ISO |
| GO:0048027 | mRNA 5'-UTR binding | ISO |
| GO:0051015 | actin filament binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000281 | mitotic cytokinesis | ISO |
| GO:0000281 | mitotic cytokinesis | IMP |
| GO:0001701 | in utero embryonic development | IMP |
| GO:0001764 | neuron migration | IMP |
| GO:0001778 | plasma membrane repair | IMP |
| GO:0003279 | cardiac septum development | IMP |
| GO:0006887 | exocytosis | IMP |
| GO:0006930 | substrate-dependent cell migration, cell extension | IMP |
| GO:0007097 | nuclear migration | IMP |
| GO:0007155 | cell adhesion | ISO |
| GO:0007409 | axonogenesis | IMP |
| GO:0007411 | axon guidance | IMP |
| GO:0007420 | brain development | IMP |
| GO:0007507 | heart development | IMP |
| GO:0007512 | adult heart development | IMP |
| GO:0008283 | cell population proliferation | IMP |
| GO:0008360 | regulation of cell shape | IMP |
| GO:0021592 | fourth ventricle development | IMP |
| GO:0021670 | lateral ventricle development | IMP |
| GO:0021678 | third ventricle development | IMP |
| GO:0021680 | cerebellar Purkinje cell layer development | IMP |
| GO:0030036 | actin cytoskeleton organization | IGI |
| GO:0030048 | actin filament-based movement | ISO |
| GO:0030239 | myofibril assembly | IMP |
| GO:0031032 | actomyosin structure organization | ISO |
| GO:0031175 | neuron projection development | IMP |
| GO:0035904 | aorta development | IMP |
| GO:0050714 | positive regulation of protein secretion | ISO |
| GO:0050885 | neuromuscular process controlling balance | IMP |
| GO:0051017 | actin filament bundle assembly | ISO |
| GO:0055003 | cardiac myofibril assembly | IMP |
| GO:0055015 | ventricular cardiac muscle cell development | IMP |
| GO:0060041 | retina development in camera-type eye | IMP |
| GO:0060976 | coronary vasculature development | IMP |
| GO:0070650 | actin filament bundle distribution | ISO |
| GO:0098885 | modification of postsynaptic actin cytoskeleton | ISO |
| GO:0098974 | postsynaptic actin cytoskeleton organization | IDA |
| GO:0098974 | postsynaptic actin cytoskeleton organization | IMP |
| GO:1905274 | regulation of modification of postsynaptic actin cytoskeleton | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001725 | stress fiber | ISO |
| GO:0001725 | stress fiber | IDA |
| GO:0001725 | stress fiber | IMP |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005829 | cytosol | ISO |
| GO:0005829 | cytosol | TAS |
| GO:0005844 | polysome | ISO |
| GO:0005903 | brush border | IDA |
| GO:0005938 | cell cortex | ISO |
| GO:0005938 | cell cortex | IDA |
| GO:0016459 | myosin complex | IDA |
| GO:0016460 | myosin II complex | ISO |
| GO:0016460 | myosin II complex | IDA |
| GO:0030027 | lamellipodium | ISO |
| GO:0030424 | axon | IDA |
| GO:0030426 | growth cone | IDA |
| GO:0030496 | midbody | ISO |
| GO:0032154 | cleavage furrow | ISO |
| GO:0042641 | actomyosin | ISO |
| GO:0043005 | neuron projection | IDA |
| GO:0043025 | neuronal cell body | IDA |
| GO:0043197 | dendritic spine | IDA |
| GO:0097513 | myosin II filament | ISO |
| GO:0098871 | postsynaptic actin cytoskeleton | ISO |
| GO:0098978 | glutamatergic synapse | ISO |
| GO:0098978 | glutamatergic synapse | IDA |
| GO:0098978 | glutamatergic synapse | IMP |
| GO:0005819 | spindle | IDA |
| GO:0005886 | plasma membrane | IDA |
| GO:0031594 | neuromuscular junction | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-194315 | Signaling by Rho GTPases | IEA |
| R-MMU-195258 | RHO GTPase Effectors | IEA |
| R-MMU-5627123 | RHO GTPases activate PAKs | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0009 | Actin-binding |
| KW-0067 | ATP-binding |
| KW-0112 | Calmodulin-binding |
| KW-0130 | Cell adhesion |
| KW-0966 | Cell projection |
| KW-0133 | Cell shape |
| KW-0175 | Coiled coil |
| KW-0488 | Methylation |
| KW-0505 | Motor protein |
| KW-0518 | Myosin |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |