Gene: Vcan

Basic information

Tag Content
Uniprot ID Q62059; Q62058; Q9CUU0;
Entrez ID
Genbank protein ID BAB29411.3; BAA03796.1; BAA06802.1;
Genbank nucleotide ID
Ensembl protein ID
Ensembl nucleotide ID
Gene name Versican core protein
Gene symbol Vcan
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 21041365
Functional description May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Sequence
MLINMKGILW MCSTLLLTHA LHQAKMETSP PVKGSLSGKV VLPCHFSTLP TLPPNYNTSE 60
FLRIKWSKME VDKNGKDIKE TTVLVAQNGN IKIGQDYKGR VSVPTHPDDV GDASLTMVKL 120
RASDAAVYRC DVMYGIEDTQ DTMSLAVDGV VFHYRAATSR YTLNFAAAQQ ACLDIGAVIA 180
SPEQLFAAYE DGFEQCDAGW LSDQTVRYPI RAPREGCYGD MMGKEGVRTY GFRSPQETYD 240
VYCYVDHLDG DVFHITAPSK FTFEEAEAEC TSRDARLATV GELQAAWRNG FDQCDYGWLS 300
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTCFPLPDSR FDAYCFKPKQ NISEATTIEM 360
NILAETSSPS LSKEPHMVPD RATPVIPLAT ELPIFTTHFP PAGNIVNSEQ KSVVYSQAIT 420
GRLATESPTT TRNTINSWDL NDSLASGSGP LGMPDISEIK EEELRSTTVI SQHATGSQAV 480
ITEDTQTHES VSQIEQIEVG PLVTSMEITN HISLKELPEK NKTPYESTEV TLEHTTEMPT 540
VSASPELATT SHYGFTLRED DREDRTLTVR SDQSTRVFSQ IPEVITVSKT SEDTTYSQLG 600
DLESISTSTI TMLGTDRSLI DKEKEPKTNG KVTEDEFGQS QPTTTFPSQH LTEVELLPYS 660
GDTTSVEGIS TVIYPSLQTD VTQGRERTET PRPELKKDPY TVDEIPEKVT KDPFIGKTEE 720
VFSGMPLSTS SSESSVERTE SVSPALTIEK LTGKPTEARD VEEMTTLTRL ETDVTKSDKD 780
VTRVHLTHST LNVEVVTVSK WPGDEDNSTS KPLPSTEHAG FTKLPPVPLS TIGINGKDKE 840
IPSFTDGGGE YTLFPDGTPK PLEKVSEEDL ASGELTVTFH TSTSIGSAEK SASGEPTTGD 900
RFLPTTSTED QVINATAEGS ALGEDTEASK PLFTGPPFVH TSDVEELAFV NYSSTQEPTT 960
YVDISHTSPL SIIPKTEWSV LETSVPLEDE ILGKSDQDIL EQTHLEATMS PGALRTTGVS 1020
QGETQEEPQT PGSPFPTFSS TAVMAKETTA FEEGEGSTYT PSEGRLMTGS ERVPGLETTP 1080
VGTSYPPGAI TDQEVEMDTM VTLMSTIRPT VVSSTESEVI YEAEGSSPTE FASTLRPFQT 1140
HVTQLMEETT EEGKKASLDY TDLGSGLFEP RATELPKFPS TPSDISVFTA IDSLHRTPPL 1200
SPSSSFTEEQ RVFEEESSEK TTGDILPGES VTQHPVTTLI DIVAMKTESD IDHMTSKPPV 1260
TQPTRPSVVE RKTTSKTQEL STSTPAAGTK FHPDINVYII EVRENKTGRL SDMIVSGHPI 1320
DSESKEEEPC SEETDPLHDL FAEILPELPD SFEIDIYHSE EDEDGEEDCV NATDVTTTPS 1380
VQYINGKQLV TTVPKDPEAA EARRGQYESV APSQNFPDSS ATDTHQFILA ETESSTTMQF 1440
KKSKEGTELL EITWKPETYP ETPDHVSSGE PDVFPTLSSH DGKTTRWSES ITESSPNLEN 1500
PVHKQPKPVP LFPEESSGEG AIEQASQETI LSRATEVALG KETDQSPTLS TSSILSSSVS 1560
VNVLEEEPLT LTGISQTDES MSTIESWVEI TPSQTVKFSE SSSAPIIEGS GEVEENKNKI 1620
FNMVTDLPQR DPTDTLSPLD MSKIMITNHH IYIPATIAPL DSKLPSPDAR PTTVWNSNST 1680
SEWVSDKSFE GRKKKENEDE EGAVNAAHQG EVRAATERSD HLLLTPELES SNVDASSDLA 1740
TWEGFILETT PTESEKEMAN STPVFRETIG VANVEAQPFE HSSSSHPRVQ EELTTLSGNP 1800
PSLFTDLGSG DASTGMELIT ASLFTLDLES ETKVKKELPS TPSPSVEISS SFEPTGLTPS 1860
TVLDIEIAGV MSQTSQKTLI SEISGKPTSQ SGVRDLYTGF PMGEDFSGDF SEYPTVSYPT 1920
MKEETVGMGG SDDERVRDTQ TSSSIPTTSD NIYPVPDSKG PDSTVASTTA FPWEEVMSSA 1980
EGSGEQLASV RSSVGPVLPL AVDIFSGTES PYFDEEFEEV AAVTEANERP TVLPTAASGN 2040
TVDLTENGYI EVNSTMSLDF PQTMEPSKLW SKPEVNLDKQ EIGRETVTKE KAQGQKTFES 2100
LHSSFAPEQT ILETQSLIET EFQTSDYSML TTLKTYITNK EVEEEGMSIA HMSTPGPGIK 2160
DLESYTTHPE APGKSHSFSA TALVTESGAA RSVLMDSSTQ EEESIKLFQK GVKLTNKESN 2220
ADLSFSGLGS GGALPPLPTT SVNLTDMKQI ISTLYAETSH MESLGTSILG DKMEDHERME 2280
DVSSNEVRML ISKIGSISQD STEALDTTLS HTGTEEPTTS TLPFVKLMDL ERSPKQDPSG 2340
GKRKPKTHRP QTMSGLISNE NSSASEAEEG ATSPTAFLPQ TYSVEMTKHF APSESQPSDL 2400
FNVNSGEGSG EVDTLDLVYT SGTTQASSQG DSMLASHGFL EKHPEVSKTE AGATDVSPTA 2460
SAMFLHHSEY KSSLYPTSTL PSTEPYKSPS EGIEDGLQDN IQFEGSTLKP SRRKTTESII 2520
IDLDKEDSKD LGLTITESAI VKSLPELTSD KNIIIDIDHT KPVYEYIPGI QTDLDPEIKL 2580
ESHGSSEESL QVQEKYEGAV TLSPTEESFE GSGDALLAGY TQAIYNESVT PNDGKQAEDI 2640
SFSFATGIPV SSTETELHTF FPTASTLHIP SKLTTASPEI DKPNIEAISL DDIFESSTLS 2700
DGQAIADQSE VISTLGHLEK TQEEYEEKKY GGPSFQPEFF SGVGEVLTDP PAYVSIGSTY 2760
LIAQTLTELP NVVRPSDSTH YTEATPEVSS LAELSPQIPS SPFPVYVDNG VSKFPEVPHT 2820
SAQPVSTVTS SQKSIESPFK EVHANIEETI KPLGGNVHRT EPPSMSRDPA LDVSEDESKH 2880
KLLEELETSP TKPETSQDFP NKAKDHIPGE TVGMLAGIRT TESEPVITAD DMELGGATQQ 2940
PHSASAAFRV ETGMVPQPIQ QEPERPTFPS LEINHETHTS LFGESILATS EKQVSQKILD 3000
NSNQATVSST LDLHTAHALS PFSILDNSNE TAFLIGISEE SVEGTAVYLP GPDLCKTNPC 3060
LNGGTCYPTE TSYVCTCAPG YSGDQCELDF DECHSNPCRN GATCVDGFNT FRCLCLPSYV 3120
GALCEQDTET CDYGWHKFQG QCYKYFAHRR TWDAAERECR LQGAHLTSIL SHEEQMFVNR 3180
VGHDYQWIGL NDKMFEHDFR WTDGSALQYE NWRPNQPDSF FSAGEDCVVI IWHENGQWND 3240
VPCNYHLTYT CKKGTVACGQ PPVVENAKTF GKMKPRYEIN SLIRYHCKDG FIQRHLPTIR 3300
CLGNGRWAMP KITCMNPSAY QRTYSKKYLK NSSSAKDNSI NTSKHEHRWS RRQETRR 3357

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005509 calcium ion bindingIEA
GO:0005540 hyaluronic acid bindingIEA
GO:0019903 protein phosphatase bindingIPI
GO:0030021 extracellular matrix structural constituent conferring compression resistanceRCA
GO:0030246 carbohydrate bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0001501 skeletal system developmentIBA
GO:0001657 ureteric bud developmentIEP
GO:0007155 cell adhesionIEA
GO:0007417 central nervous system developmentIBA
GO:0007507 heart developmentIMP
GO:0008347 glial cell migrationISO
GO:0043666 regulation of phosphoprotein phosphatase activityIDA
GO:0043666 regulation of phosphoprotein phosphatase activityISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0001750 photoreceptor outer segmentIEA
GO:0009986 cell surfaceISO
GO:0031012 extracellular matrixIDA
GO:0031012 extracellular matrixIBA
GO:0033165 interphotoreceptor matrixIEA
GO:0045202 synapseISO
GO:0062023 collagen-containing extracellular matrixISO
GO:0062023 collagen-containing extracellular matrixHDA
GO:0072534 perineuronal netISO

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0106 Calcium
KW-0966 Cell projection
KW-0903 Direct protein sequencing
KW-1015 Disulfide bond
KW-0245 EGF-like domain
KW-0272 Extracellular matrix
KW-0325 Glycoprotein
KW-0373 Hyaluronic acid
KW-0393 Immunoglobulin domain
KW-0430 Lectin
KW-0597 Phosphoprotein
KW-0654 Proteoglycan
KW-1185 Reference proteome
KW-0677 Repeat
KW-0964 Secreted
KW-0732 Signal
KW-0768 Sushi

Interpro

InterPro ID InterPro Term
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033987 CSPG_CTLD
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

PROSITE

PROSITE ID PROSITE Term
PS00010 ASX_HYDROXYL
PS00615 C_TYPE_LECTIN_1
PS50041 C_TYPE_LECTIN_2
PS00022 EGF_1
PS01186 EGF_2
PS50026 EGF_3
PS01187 EGF_CA
PS50835 IG_LIKE
PS01241 LINK_1
PS50963 LINK_2
PS50923 SUSHI

Pfam

Pfam ID Pfam Term
PF00008 EGF
PF00059 Lectin_C
PF00084 Sushi
PF07686 V-set
PF00193 Xlink

Protein-miRNA interaction