| Tag | Content |
|---|---|
| Uniprot ID | Q64008; Q8BHJ0; Q99P59; Q99P90; |
| Entrez ID | 19376 |
| Genbank protein ID | AAH38638.1; AAK09398.1; BAC16803.1; AAK11241.1; AAB20669.1; |
| Genbank nucleotide ID | NM_001159482.1; NM_033475.3; |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Ras-related protein Rab-34 |
| Gene symbol | Rab34 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 27626380 |
| Functional description | Transport protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:12475955). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (PubMed:29290584). |
| Sequence | MNILAPVRRD RVLAELPQCL KKEAALHVRK DFHPRVTCAC QEHRTGTVGF KISKVIVVGD 60 LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGVP FSLQLWDTAG QERFKCIAST 120 YYRGAQAIII VFNLNDVASL EHTKQWLTDA LKENDPSNVL LFLVGSKKDL STPAQYSLME 180 KDALKVAQEI KAEYWAVSSL TGENVREFFF RVAALTFEAN VLADVEKSGA RHIADVVRIN 240 SDDKNLYLTA SKKKATCCP 259 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003924 | GTPase activity | IDA |
| GO:0003924 | GTPase activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005525 | GTP binding | IEA |
| GO:0017160 | Ral GTPase binding | ISO |
| GO:0019001 | guanyl nucleotide binding | IDA |
| GO:0030742 | GTP-dependent protein binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006886 | intracellular protein transport | IBA |
| GO:0006897 | endocytosis | IDA |
| GO:0006897 | endocytosis | IBA |
| GO:0007041 | lysosomal transport | IDA |
| GO:0019882 | antigen processing and presentation | ISO |
| GO:0030030 | cell projection organization | IEA |
| GO:0032418 | lysosome localization | ISO |
| GO:0032482 | Rab protein signal transduction | IBA |
| GO:0043001 | Golgi to plasma membrane protein transport | ISO |
| GO:0043001 | Golgi to plasma membrane protein transport | IGI |
| GO:0045880 | positive regulation of smoothened signaling pathway | IMP |
| GO:0050714 | positive regulation of protein secretion | ISO |
| GO:0071333 | cellular response to glucose stimulus | ISO |
| GO:0072659 | protein localization to plasma membrane | ISO |
| GO:0090382 | phagosome maturation | ISS |
| GO:0090382 | phagosome maturation | ISO |
| GO:0090385 | phagosome-lysosome fusion | ISS |
| GO:0090385 | phagosome-lysosome fusion | ISO |
| GO:0090385 | phagosome-lysosome fusion | IBA |
| GO:0090385 | phagosome-lysosome fusion | IMP |
| GO:1900426 | positive regulation of defense response to bacterium | IDA |
| GO:1905171 | positive regulation of protein localization to phagocytic vesicle | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001726 | ruffle | IDA |
| GO:0005623 | cell | IEA |
| GO:0005769 | early endosome | IDA |
| GO:0005770 | late endosome | IDA |
| GO:0005794 | Golgi apparatus | ISO |
| GO:0005794 | Golgi apparatus | IDA |
| GO:0005795 | Golgi stack | ISO |
| GO:0005929 | cilium | IEA |
| GO:0012505 | endomembrane system | IBA |
| GO:0030670 | phagocytic vesicle membrane | IEA |
| GO:0031410 | cytoplasmic vesicle | IDA |
| GO:0031982 | vesicle | ISO |
| GO:0031985 | Golgi cisterna | ISO |
| GO:0045335 | phagocytic vesicle | ISS |
| GO:0045335 | phagocytic vesicle | ISO |
| GO:0048471 | perinuclear region of cytoplasm | ISO |
| GO:0045335 | phagocytic vesicle | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-8873719 | RAB geranylgeranylation | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0966 | Cell projection |
| KW-0970 | Cilium biogenesis/degradation |
| KW-0963 | Cytoplasm |
| KW-0968 | Cytoplasmic vesicle |
| KW-0333 | Golgi apparatus |
| KW-0342 | GTP-binding |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0636 | Prenylation |
| KW-0653 | Protein transport |
| KW-1185 | Reference proteome |
| KW-0813 | Transport |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51419 | RAB |
| Pfam ID | Pfam Term |
|---|---|
| PF00071 | Ras |